rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(78), CAMP(1), CREB5(7), MAPK1(3), RAF1(2), SNX13(1), SRC(1)	2251916	93	80	31	23	25	3	2	63	0	0	0.133	6.79e-05	0.0398
2	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CCND1(1), CDK4(2), CDKN1A(2), CDKN1B(1), CDKN2A(23), CFL1(1), E2F1(5), E2F2(3), MDM2(2), NXT1(2), PRB1(18), TP53(26)	1704325	86	52	72	14	40	3	4	10	29	0	2.01e-05	0.000129	0.0398
3	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(12), CCND1(1), CCNE1(3), CCNE2(10), CDK4(2), CDKN1B(1), CDKN2A(23), E2F1(5), E2F2(3), PRB1(18)	1815524	78	54	64	13	41	0	4	12	21	0	0.000109	0.000917	0.188
4	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4), IL8(1), SLPI(5)	346525	10	10	10	2	4	1	0	4	1	0	0.226	0.138	1.000
5	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(3), FOSB(5), GRIA2(22), PPP1R1B(1)	731255	31	25	28	8	22	1	0	4	4	0	0.0327	0.146	1.000
6	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(8)	144360	8	8	8	2	7	1	0	0	0	0	0.171	0.224	1.000
7	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(1), MYC(2), SP1(4), SP3(1), TP53(26), WT1(4)	1428799	38	29	35	5	18	2	5	4	9	0	0.00325	0.224	1.000
8	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3)	1133089	78	50	71	20	59	5	4	8	2	0	0.00130	0.510	1.000
9	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(5), DCN(14), FMOD(3), KERA(13), LUM(7)	704012	42	28	41	13	34	3	2	1	2	0	0.00465	0.636	1.000
10	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(3), ALDH1A2(9), BCMO1(10), RDH5(1)	785999	23	20	22	7	15	2	1	3	2	0	0.0662	0.784	1.000
11	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(4), CHRNA1(3), SNAP25(5), STX1A(2)	659260	14	11	12	3	10	0	0	1	3	0	0.0515	0.817	1.000
12	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	103800	1	1	1	1	1	0	0	0	0	0	0.896	0.876	1.000
13	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(5), ACADS(2), HADHA(7)	1105580	16	14	16	4	10	1	1	4	0	0	0.196	0.906	1.000
14	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(3), CDKN2A(23), E2F1(5), MDM2(2), MYC(2), PIK3CA(2), PIK3R1(2), POLR1A(7), POLR1B(5), POLR1C(1), RAC1(9), RB1(3), TBX2(2), TP53(26), TWIST1(1)	4072150	93	53	76	18	49	3	3	8	28	2	7.29e-05	0.923	1.000
15	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(5), CD3E(2)	226627	7	5	7	3	6	0	0	0	1	0	0.499	0.932	1.000
16	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2)	334020	2	2	2	1	1	0	0	1	0	0	0.741	0.935	1.000
17	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2), CASP3(1), CASP8(2), CFL1(1), CFLAR(3), PDE6D(2)	788035	11	9	11	3	4	1	2	4	0	0	0.314	0.938	1.000
18	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOA(1), ALDOB(8), ALDOC(1)	795772	12	9	11	3	8	1	0	1	2	0	0.0981	0.974	1.000
19	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(4), GOT2(2), TAT(12)	530657	18	11	18	6	14	1	2	1	0	0	0.116	0.981	1.000
20	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(3), CDC34(3), CUL1(4), E2F1(5), FBXW7(9), RB1(3), TFDP1(1)	1631923	28	22	28	9	14	2	3	3	4	2	0.200	0.985	1.000
21	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADHA(7), HADHB(2), HSD17B10(1), HSD17B4(3), MECR(4), PPT1(3), PPT2(4)	1705533	25	23	25	7	12	2	3	7	1	0	0.168	0.986	1.000
22	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2)	312382	2	1	2	0	0	1	0	0	1	0	0.527	0.988	1.000
23	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(4), SEC61A2(4), SRP19(4), SRP54(2), SRP68(5), SRP72(1), SRPR(2)	1542050	22	19	20	6	10	0	1	6	5	0	0.322	0.989	1.000
24	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(5), HADHA(7)	974332	13	12	12	5	9	1	0	3	0	0	0.336	0.990	1.000
25	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(3), MTMR2(1), MTMR6(2), NFS1(3), TPK1(3)	1284130	13	12	13	2	10	1	1	0	1	0	0.0952	0.991	1.000
26	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(3), SQLE(2)	640942	5	5	5	2	3	1	0	1	0	0	0.551	0.992	1.000
27	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(5), HADHA(7), HSD17B10(1), HSD17B4(3), NTAN1(1), SIRT2(1), SIRT5(5), SIRT7(2), VNN2(9)	2380431	35	26	34	7	23	3	3	6	0	0	0.0151	0.993	1.000
28	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(1), RB1(3), SP1(4), SP3(1)	1342774	10	9	10	3	1	2	1	2	2	2	0.523	0.993	1.000
29	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), EHHADH(5), GCDH(3), HADHA(7)	1571520	16	13	15	4	11	2	0	3	0	0	0.133	0.993	1.000
30	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(3), IFNG(2), IL12A(2), IL12B(3), IL18(2), IL2(4)	590656	16	7	16	5	11	2	0	1	2	0	0.153	0.995	1.000
31	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), TGDS(1), UXS1(1)	777849	4	4	4	3	1	0	0	0	3	0	0.935	0.996	1.000
32	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(3), RAB11A(1), RAB27A(3), RAB3A(2)	847829	9	7	9	3	7	0	1	1	0	0	0.338	0.996	1.000
33	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(9), COASY(3), DPYD(38), DPYS(15), ENPP1(9), ENPP3(10), PANK2(2), PANK3(1), PANK4(4), PPCS(3), UPB1(5)	2787251	99	53	91	27	74	6	4	7	8	0	0.000808	0.997	1.000
34	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(12), CCND1(1), CCND2(4), CCND3(1), CCNE1(3), CCNH(1), CDC25A(6), CDK4(2), CDK6(1), CDKN1A(2), CDKN1B(1), CDKN2A(23), CDKN2C(1), E2F1(5), RB1(3), RBL1(5), TFDP1(1)	3254316	72	49	62	20	36	3	4	6	21	2	0.00746	0.998	1.000
35	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(3), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB7(1), PSMB8(2)	1777148	17	14	17	3	10	2	2	1	2	0	0.0766	0.998	1.000
36	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), CBS(5), MUT(4)	1025585	10	10	10	4	8	0	0	1	1	0	0.441	0.999	1.000
37	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(8), LPL(2), NR3C1(2), PPARG(8), RETN(3), RXRA(1), TNF(1)	1173572	25	21	23	8	18	2	0	3	2	0	0.0702	0.999	1.000
38	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(6), GGT1(4), SHMT2(2)	813938	12	11	12	7	9	0	0	2	1	0	0.463	0.999	1.000
39	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(9), BCAT2(1), COASY(3), DPYD(38), DPYS(15), ENPP1(9), ENPP3(10), ILVBL(2), PANK2(2), PANK3(1), PANK4(4), PPCS(3), UPB1(5), VNN1(4)	3457773	106	54	98	29	79	6	4	8	9	0	0.000208	0.999	1.000
40	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), TGDS(1), UGP2(1), UXS1(1)	991913	5	5	5	4	2	0	0	0	3	0	0.941	1.000	1.000
41	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(4)	623865	6	6	6	5	3	0	1	1	1	0	0.834	1.000	1.000
42	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), CYCS(1), GPD2(1), SDHA(1), SDHC(2), UQCRC1(3)	1338329	9	9	9	2	6	0	1	1	1	0	0.220	1.000	1.000
43	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), HMGCL(2), OXCT1(3)	676623	6	6	6	3	4	0	0	1	1	0	0.667	1.000	1.000
44	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PLCD1(2), PRKCA(8), TGM2(4)	999429	16	10	15	7	12	2	0	0	2	0	0.125	1.000	1.000
45	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(2), IFNG(2), IFNGR1(3), IFNGR2(2), IKBKB(2), JAK2(6), LIN7A(10), NFKB1(3), NFKBIA(2), RB1(3), RELA(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(26), USH1C(13), WT1(4)	3626636	84	47	80	22	41	5	5	13	18	2	0.00476	1.000	1.000
46	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(3), NFKBIA(2), PLCB1(33), PRKCA(8), RELA(2)	1643646	49	33	45	18	41	2	1	2	3	0	0.0826	1.000	1.000
47	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGAL(17), ITGAM(19), ITGB2(10), SELE(22), SELL(6)	2055530	81	40	81	25	62	3	1	5	10	0	0.00102	1.000	1.000
48	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(9), IARS(5), LARS(8), LARS2(3), PDHA1(1), PDHA2(9), PDHB(1)	2028403	36	22	35	8	26	3	0	3	4	0	0.0345	1.000	1.000
49	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(8), CSF2(2), HLA-DRA(7), HLA-DRB1(2), IL3(2), IL5(4)	609236	26	18	25	11	22	1	0	2	1	0	0.0650	1.000	1.000
50	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(30), NRG2(5), NRG3(14), PRKCA(8), PSEN1(1)	1787629	59	41	54	17	46	4	2	4	3	0	0.0143	1.000	1.000
51	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(2), GBA3(6), GGT1(4), SHMT2(2)	1074646	15	12	15	7	12	0	0	2	1	0	0.313	1.000	1.000
52	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(3), ATM(10), BAX(1), BCL2(2), CCND1(1), CCNE1(3), CDK4(2), CDKN1A(2), E2F1(5), MDM2(2), PCNA(1), RB1(3), TIMP3(4), TP53(26)	3619700	65	45	61	16	30	5	4	9	15	2	0.0252	1.000	1.000
53	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(2), PAPSS2(4), SULT1A2(2), SULT1E1(10), SULT2A1(4), SUOX(3)	1224048	25	13	24	7	20	0	0	2	3	0	0.0853	1.000	1.000
54	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDKN1B(1), CUL1(4), E2F1(5), RB1(3), TFDP1(1), UBE2M(1)	1729176	18	17	18	9	8	2	2	2	2	2	0.556	1.000	1.000
55	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(3), ACTR2(2), ARPC1B(2), ARPC2(1), ARPC3(1), RAC1(9), WASF1(1), WASL(3)	1634225	22	18	18	6	18	0	1	1	2	0	0.128	1.000	1.000
56	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(3), IFNGR2(2), JAK1(4), JAK2(6), STAT1(2)	1640410	19	11	19	6	8	0	1	6	4	0	0.499	1.000	1.000
57	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(3), ACP2(2), ACP5(3), ACPP(6), ENPP1(9), ENPP3(10), FLAD1(6), TYR(5)	1940575	44	30	43	13	29	3	2	3	7	0	0.0521	1.000	1.000
58	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(1), DNAJC3(2), EIF2S1(1), MAP3K14(1), NFKB1(3), NFKBIA(2), RELA(2), TP53(26)	1945612	38	30	35	12	22	1	3	3	9	0	0.152	1.000	1.000
59	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(3), BAX(1), BCL2(2), BIK(1), BIRC2(4), BIRC3(6), CASP3(1), CASP7(4), CASP8(2), CASP9(3), CYCS(1), DFFA(1), DFFB(2), DIABLO(1)	2713990	32	24	32	9	19	3	5	4	1	0	0.0914	1.000	1.000
60	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(3), GLUD1(1), GLUD2(1)	913160	6	4	6	6	3	2	0	0	1	0	0.898	1.000	1.000
61	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(12), CCNE1(3), CDC34(3), CUL1(4), E2F1(5), RB1(3), TFDP1(1)	1711009	31	25	31	12	21	2	2	2	2	2	0.194	1.000	1.000
62	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BAX(1), BCL10(1), BCL2(2), BCL2L11(3), CASP8AP2(3), CASP9(3), CES1(12)	2175480	28	18	28	8	22	3	1	0	2	0	0.0979	1.000	1.000
63	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(1), CASP7(4), DFFA(1), DFFB(2), GZMB(2), HMGB1(1), TOP2A(4), TOP2B(4)	1805401	19	14	19	6	13	1	3	1	1	0	0.311	1.000	1.000
64	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(6), CDC25B(3), CDKN1A(2), CHEK1(1), NEK1(7), WEE1(2)	1392434	21	16	21	6	12	4	1	1	3	0	0.256	1.000	1.000
65	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(3), ACP2(2), ACP5(3), ACP6(8), ACPP(6), ENPP1(9), ENPP3(10), FLAD1(6), LHPP(1), MTMR1(3), MTMR2(1), MTMR6(2), TYR(5)	3008696	59	37	58	15	38	4	5	4	8	0	0.0111	1.000	1.000
66	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	CAMP(1), DAG1(3), GNAQ(1), ITPKB(5)	1206635	10	10	10	5	8	0	1	0	1	0	0.414	1.000	1.000
67	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(5), ICAM1(2), ITGA4(26), ITGAL(17), ITGB1(4), ITGB2(10), SELE(22), SELL(6)	2396749	92	46	89	28	71	3	2	7	9	0	0.00549	1.000	1.000
68	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), GOT1(4), GOT2(2), LDHA(2), LDHC(3), MPST(2)	1383311	19	15	18	8	15	0	4	0	0	0	0.262	1.000	1.000
69	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(4), CBS(5), GGT1(4), MARS(5), MARS2(3), MAT1A(4), MAT2B(1), PAPSS1(2), PAPSS2(4), SCLY(2), SEPHS1(4)	2505285	38	29	38	11	24	1	2	6	5	0	0.0243	1.000	1.000
70	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(3), CYSLTR2(2), GPR109B(7), GPR161(6), GPR171(6), GPR18(1), GPR39(8), GPR45(5), GPR65(7), GPR68(2), GPR75(4), GPR81(3)	1963085	54	36	53	25	40	3	3	2	6	0	0.00442	1.000	1.000
71	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(5), POLR2A(10), POLR2B(11), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(1)	2684332	34	28	34	10	21	3	2	5	3	0	0.0640	1.000	1.000
72	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(3), GGPS1(1), SQLE(2)	856337	6	6	6	4	4	1	0	1	0	0	0.747	1.000	1.000
73	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(2), BMPR1A(1), BMPR1B(2), BMPR2(4)	1264076	9	9	9	7	7	1	0	0	1	0	0.840	1.000	1.000
74	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(3), ALAS2(2), CPOX(2), FECH(2), HMBS(1), PPOX(2), UROS(1)	1520529	13	11	13	7	10	1	0	0	2	0	0.515	1.000	1.000
75	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(4), CD3D(5), CD3E(2), GZMB(2), HLA-A(2), ICAM1(2), ITGAL(17), ITGB2(10), PRF1(6)	1745521	50	30	49	22	33	5	0	3	9	0	0.0869	1.000	1.000
76	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(3), ACAA2(1), ACAT2(1), EHHADH(5), HADHA(7), HADHB(2)	1682118	19	17	18	8	13	2	0	3	1	0	0.443	1.000	1.000
77	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(6), CASP8(2), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2)	1645493	16	14	16	7	11	1	1	2	1	0	0.378	1.000	1.000
78	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(3), AASDH(4), AASDHPPT(1), AASS(1), KARS(3)	1385893	12	10	12	6	10	0	0	1	1	0	0.698	1.000	1.000
79	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(10), NR0B2(6), NR1H3(2), NR1H4(10), RXRA(1)	1093704	29	19	29	12	19	6	2	0	2	0	0.0948	1.000	1.000
80	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(12), RANGAP1(2)	1715595	14	14	14	8	10	2	0	0	2	0	0.830	1.000	1.000
81	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(3), CPS1(13), GLS(1), GLUD1(1), GOT1(4)	1528431	23	14	22	10	15	3	2	3	0	0	0.377	1.000	1.000
82	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(4), PARK2(4), SNCAIP(37), UBE2E2(2), UBE2F(4), UBE2L6(1)	1294284	52	35	46	19	42	6	0	3	1	0	0.0978	1.000	1.000
83	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO3(2), FARS2(3), GOT1(4), GOT2(2), PAH(3), TAT(12), YARS(1)	1681127	29	20	29	14	24	2	2	1	0	0	0.177	1.000	1.000
84	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(4), BHMT(6), CBS(5), DNMT1(13), DNMT3A(5), DNMT3B(9), MARS(5), MARS2(3), MAT1A(4), MAT2B(1), MTR(5)	3549624	60	36	59	17	37	3	3	9	8	0	0.00975	1.000	1.000
85	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(2), IFNGR1(3), JAK1(4), JAK2(6), PLA2G2A(2), PTPRU(12), REG1A(5), STAT1(2)	2291781	38	23	38	13	22	1	1	8	6	0	0.129	1.000	1.000
86	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(2), GSR(2), GSS(5), IL8(1), NFKB1(3), NOX1(7), RELA(2), TNF(1), XDH(38)	1979405	61	35	61	29	47	4	4	4	2	0	0.111	1.000	1.000
87	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(3), FARSA(5), FARSB(5), GOT1(4), GOT2(2), PAH(3), TAT(12), YARS(1), YARS2(1)	1753710	36	24	35	16	24	5	2	2	3	0	0.165	1.000	1.000
88	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(14), DAXX(5), HRAS(1), PAX3(2), PML(1), RARA(1), RB1(3), SP100(6), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(26)	3773561	63	39	60	20	32	5	6	6	12	2	0.0667	1.000	1.000
89	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(6), ALPP(6), ALPPL2(7), FPGS(3), GGH(2), SPR(1)	1275705	28	18	27	12	22	3	2	0	1	0	0.0830	1.000	1.000
90	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(4), GNAQ(1), HTR2C(6), PLCB1(33), TUB(5)	1434605	49	32	46	24	43	0	0	3	3	0	0.182	1.000	1.000
91	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(6), CS(1), MDH1(1), ME1(14), PC(6), PDHA1(1), SLC25A11(1)	1873371	30	20	30	14	19	4	1	4	2	0	0.242	1.000	1.000
92	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(6), CDC25B(3), CDC25C(3), MNAT1(2), SHH(2)	1755409	17	14	17	8	12	2	1	2	0	0	0.552	1.000	1.000
93	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(1), NDUFB2(1), NDUFB5(1), NDUFB6(2), NDUFS2(1), NDUFV1(1)	1408122	7	7	7	6	6	0	0	0	1	0	0.922	1.000	1.000
94	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(5), CHAT(11), CHKA(2), PCYT1A(2), PDHA1(1), PDHA2(9), PEMT(1), SLC18A3(2)	1378187	33	22	33	14	29	1	0	1	2	0	0.0834	1.000	1.000
95	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(3), POLD2(2), POLE(10), POLG(4), POLL(7), POLQ(15)	3356817	41	34	40	16	20	3	2	8	8	0	0.202	1.000	1.000
96	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(5), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(2)	1141369	11	11	11	7	7	1	1	2	0	0	0.676	1.000	1.000
97	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF2(2), CSF3(2), EPO(4), FLT3(21), IGF1(7), IL11(2), IL1A(3), IL3(2), KITLG(6), TGFB2(1), TGFB3(1)	1651719	51	32	49	21	36	3	2	5	5	0	0.0778	1.000	1.000
98	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(5), IFNG(2), IL10(2), IL12A(2), IL12B(3), IL13(2), IL15(1), IL16(10), IL18(2), IL1A(3), IL2(4), IL3(2), IL4(1), IL5(4), IL8(1), LTA(2), TNF(1)	1983790	47	27	46	21	35	3	1	1	7	0	0.0447	1.000	1.000
99	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(4), BHMT(6), CBS(5), DNMT1(13), DNMT3A(5), DNMT3B(9), MARS(5), MARS2(3), MAT1A(4), MAT2B(1), MTAP(4), MTFMT(1), MTR(5), TAT(12)	4215946	77	40	76	25	49	5	4	11	8	0	0.0123	1.000	1.000
100	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(3), APAF1(3), BCL2(2), CASP3(1), CASP9(3), CYCS(1), DAXX(5), FAS(3), FASLG(10), HSPB1(2), HSPB2(1), IL1A(3), MAPKAPK2(2), MAPKAPK3(1), TNF(1)	2288158	41	29	41	15	29	2	1	2	7	0	0.0698	1.000	1.000
101	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(5), ICAM1(2), ITGA4(26), ITGAL(17), ITGAM(19), ITGB1(4), ITGB2(10), SELE(22), SELL(6), SELP(15)	3153951	126	54	121	40	99	3	2	10	12	0	0.00132	1.000	1.000
102	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3D(5), CD3E(2), IFNG(2), IL2(4), IL2RA(4), IL4(1), TGFB2(1), TGFB3(1), TGFBR2(5), TGFBR3(5), TOB1(2), TOB2(2)	2111583	34	22	34	13	27	1	0	0	6	0	0.107	1.000	1.000
103	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(3), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB7(1), PSMC2(1), PSMC3(2), PSMD1(4), PSMD12(1), PSMD13(3), PSMD2(2)	3249330	28	23	27	10	17	4	2	3	2	0	0.254	1.000	1.000
104	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(6), CARS2(1), CDO1(3), GOT1(4), GOT2(2), LDHA(2), LDHAL6A(1), LDHAL6B(6), LDHC(3), MPST(2), SULT1B1(8), SULT1C2(1), SULT1C4(10), SULT4A1(7)	2524760	56	34	54	22	41	2	6	1	6	0	0.0618	1.000	1.000
105	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(1), APAF1(3), ATM(10), BAX(1), BCL2(2), CASP3(1), CASP7(4), CASP9(3), CYCS(1), EIF2S1(1), PRKCA(8), PTK2(3), PXN(3), STAT1(2), TLN1(10), TP53(26)	5478475	79	47	74	26	44	7	5	10	13	0	0.0420	1.000	1.000
106	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(6), FDPS(3), HMGCR(8), HMGCS1(1), LSS(2), MVD(1), MVK(2), NSDHL(3), PMVK(1), SC4MOL(3), SC5DL(1), SQLE(2)	2643687	34	25	33	13	18	8	0	5	3	0	0.200	1.000	1.000
107	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2)	2653090	95	56	88	32	69	7	6	8	5	0	0.00259	1.000	1.000
108	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), AKT2(6), AKT3(3), CDKN1A(2), ELK1(1), GRB2(2), HRAS(1), MAP2K1(7), MAP2K2(2), NGFR(6), NTRK1(10), PIK3CA(2), PIK3CD(2), SHC1(1), SOS1(6)	3185693	52	35	49	20	28	10	2	8	4	0	0.153	1.000	1.000
109	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(10), CDC25A(6), CDC25B(3), CDC25C(3), CDK4(2), CHEK1(1), MYT1(15), RB1(3), TP53(26), WEE1(2)	3535107	71	48	67	25	39	4	3	8	15	2	0.180	1.000	1.000
110	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(3), ACVR1C(7), AKT1(1), AKT2(6), AKT3(3), ARRB1(2), ARRB2(3), ATF2(5), ATF4(4), BDNF(3), BRAF(78), CACNA1A(22), CACNA1B(20), CACNA1C(30), CACNA1D(23), CACNA1E(71), CACNA1F(15), CACNA1G(23), CACNA1H(17), CACNA1I(21), CACNA1S(30), CACNA2D1(8), CACNA2D2(11), CACNA2D3(33), CACNA2D4(14), CACNB1(2), CACNB2(8), CACNB3(2), CACNB4(7), CACNG1(3), CACNG2(4), CACNG3(11), CACNG4(3), CACNG5(9), CACNG6(2), CACNG7(2), CASP3(1), CD14(4), CDC25B(3), CHP(1), CHUK(1), CRK(2), DAXX(5), DDIT3(1), DUSP10(6), DUSP14(1), DUSP16(1), DUSP2(1), DUSP4(1), DUSP5(2), DUSP6(1), DUSP7(1), DUSP8(1), DUSP9(1), ECSIT(1), EGF(14), EGFR(16), ELK1(1), ELK4(5), FAS(3), FASLG(10), FGF11(2), FGF12(10), FGF13(4), FGF14(5), FGF16(1), FGF17(1), FGF18(2), FGF19(2), FGF2(1), FGF21(2), FGF23(3), FGF3(4), FGF4(2), FGF5(3), FGF6(1), FGF7(6), FGF8(1), FGF9(2), FGFR1(7), FGFR2(21), FGFR3(7), FGFR4(8), FLNA(8), FLNB(26), FLNC(37), FOS(1), GADD45B(1), GNA12(2), GRB2(2), HRAS(1), IKBKB(2), IL1A(3), IL1B(5), IL1R1(7), IL1R2(5), JUN(1), KRAS(1), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K5(2), MAP2K6(2), MAP2K7(2), MAP3K10(5), MAP3K12(3), MAP3K13(5), MAP3K14(1), MAP3K2(4), MAP3K3(4), MAP3K4(11), MAP3K5(11), MAP3K6(6), MAP4K1(6), MAP4K2(4), MAP4K3(5), MAP4K4(6), MAPK1(3), MAPK10(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK3(1), MAPK7(2), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(6), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MAPT(7), MEF2C(2), MKNK1(5), MKNK2(2), MOS(5), MRAS(1), MYC(2), NF1(25), NFATC2(6), NFATC4(5), NFKB1(3), NFKB2(3), NLK(4), NR4A1(2), NRAS(39), NTF3(3), NTRK1(10), NTRK2(7), PAK1(2), PAK2(2), PDGFA(1), PDGFB(2), PDGFRA(15), PDGFRB(10), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PPM1A(2), PPM1B(5), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PPP5C(2), PRKACA(2), PRKACB(2), PRKACG(7), PRKCA(8), PRKCG(10), PRKX(1), PTPN5(9), PTPN7(1), PTPRR(19), RAC1(9), RAF1(2), RAP1A(1), RAPGEF2(6), RASA1(1), RASA2(11), RASGRF1(16), RASGRF2(11), RASGRP1(7), RASGRP2(3), RASGRP3(8), RASGRP4(9), RPS6KA1(4), RPS6KA2(4), RPS6KA4(2), RPS6KA5(4), RPS6KA6(5), RRAS(1), SOS1(6), SOS2(3), SRF(1), STK4(3), STMN1(1), TAOK1(8), TAOK2(18), TAOK3(1), TGFB2(1), TGFB3(1), TGFBR2(5), TNF(1), TNFRSF1A(2), TP53(26), TRAF2(2), TRAF6(2), ZAK(5)	56403823	1395	132	1255	750	913	116	51	192	119	4	0.0355	1.000	1.000
111	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(3), APC(12), APC2(4), ARHGEF1(1), ARHGEF12(6), ARHGEF4(3), ARHGEF6(5), ARHGEF7(2), ARPC1B(2), ARPC2(1), ARPC3(1), BAIAP2(3), BCAR1(3), BDKRB1(5), BDKRB2(2), BRAF(78), CD14(4), CFL1(1), CHRM1(4), CHRM2(10), CHRM3(11), CHRM4(5), CHRM5(2), CRK(2), CSK(1), CYFIP1(3), CYFIP2(18), DIAPH1(6), DIAPH2(4), DIAPH3(4), DOCK1(13), EGF(14), EGFR(16), EZR(1), F2(6), F2R(4), FGD1(2), FGD3(4), FGF11(2), FGF12(10), FGF13(4), FGF14(5), FGF16(1), FGF17(1), FGF18(2), FGF19(2), FGF2(1), FGF21(2), FGF23(3), FGF3(4), FGF4(2), FGF5(3), FGF6(1), FGF7(6), FGF8(1), FGF9(2), FGFR1(7), FGFR2(21), FGFR3(7), FGFR4(8), FN1(10), GIT1(4), GNA12(2), GNA13(1), GRLF1(3), GSN(5), HRAS(1), IQGAP1(7), IQGAP2(16), IQGAP3(7), ITGA1(15), ITGA10(4), ITGA11(13), ITGA2(7), ITGA2B(7), ITGA3(4), ITGA4(26), ITGA5(13), ITGA6(6), ITGA7(15), ITGA8(26), ITGA9(9), ITGAD(17), ITGAE(8), ITGAL(17), ITGAM(19), ITGAV(5), ITGAX(14), ITGB1(4), ITGB2(10), ITGB3(9), ITGB4(12), ITGB5(1), ITGB6(8), ITGB7(4), ITGB8(10), KRAS(1), LIMK1(4), LIMK2(6), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), MOS(5), MRAS(1), MYH10(6), MYH14(14), MYH9(6), MYL2(4), MYL5(1), MYL9(1), MYLK(22), MYLK2(6), MYLPF(1), NCKAP1(2), NCKAP1L(22), NRAS(39), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PDGFA(1), PDGFB(2), PDGFRA(15), PDGFRB(10), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(6), PIP5K1B(15), PIP5K1C(4), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R12A(3), PPP1R12B(5), PTK2(3), PXN(3), RAC1(9), RAF1(2), ROCK1(3), ROCK2(4), RRAS(1), SCIN(5), SLC9A1(1), SOS1(6), SOS2(3), SSH1(10), SSH2(6), SSH3(3), TIAM1(20), TIAM2(20), TMSL3(2), VAV1(13), VAV2(3), VAV3(6), VCL(4), WAS(5), WASF1(1), WASF2(4), WASL(3)	54964274	1181	131	1059	580	787	70	46	197	78	3	0.00163	1.000	1.000
112	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(4), ACTG1(4), ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(3), AKT1(1), AKT2(6), AKT3(3), ARHGAP5(9), BCAR1(3), BCL2(2), BIRC2(4), BIRC3(6), BRAF(78), CAPN2(2), CAV1(1), CCND1(1), CCND2(4), CCND3(1), CHAD(3), COL11A1(38), COL11A2(26), COL1A1(28), COL1A2(31), COL2A1(18), COL3A1(44), COL4A1(33), COL4A2(20), COL4A4(58), COL4A6(28), COL5A1(43), COL5A2(28), COL5A3(46), COL6A1(7), COL6A2(7), COL6A3(36), COL6A6(33), COMP(5), CRK(2), CTNNB1(6), DIAPH1(6), DOCK1(13), EGF(14), EGFR(16), ELK1(1), ERBB2(3), FARP2(2), FIGF(4), FLNA(8), FLNB(26), FLNC(37), FLT1(21), FN1(10), FYN(5), GRB2(2), GRLF1(3), GSK3B(2), HGF(13), HRAS(1), IBSP(6), IGF1(7), IGF1R(6), ITGA1(15), ITGA10(4), ITGA11(13), ITGA2(7), ITGA2B(7), ITGA3(4), ITGA4(26), ITGA5(13), ITGA6(6), ITGA7(15), ITGA8(26), ITGA9(9), ITGAV(5), ITGB1(4), ITGB3(9), ITGB4(12), ITGB5(1), ITGB6(8), ITGB7(4), ITGB8(10), JUN(1), KDR(25), LAMA1(30), LAMA2(31), LAMA3(38), LAMA4(4), LAMA5(20), LAMB1(7), LAMB2(6), LAMB3(18), LAMB4(23), LAMC1(9), LAMC2(15), LAMC3(6), MAP2K1(7), MAPK1(3), MAPK10(6), MAPK3(1), MAPK9(1), MET(12), MYL2(4), MYL5(1), MYL9(1), MYLK(22), MYLK2(6), MYLPF(1), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PARVA(1), PARVB(1), PARVG(3), PDGFA(1), PDGFB(2), PDGFC(14), PDGFD(5), PDGFRA(15), PDGFRB(10), PDPK1(3), PGF(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PIP5K1C(4), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R12A(3), PRKCA(8), PRKCG(10), PTEN(12), PTK2(3), PXN(3), RAC1(9), RAF1(2), RAP1A(1), RAPGEF1(4), RELN(46), ROCK1(3), ROCK2(4), SHC1(1), SHC2(4), SHC3(9), SHC4(1), SOS1(6), SOS2(3), SPP1(4), SRC(1), THBS1(19), THBS2(8), THBS3(7), THBS4(7), TLN1(10), TLN2(15), TNC(20), TNN(32), TNR(46), TNXB(78), VASP(1), VAV1(13), VAV2(3), VAV3(6), VCL(4), VEGFA(1), VEGFB(1), VEGFC(14), VTN(7), VWF(32), ZYX(4)	74266606	2018	128	1905	913	1480	132	54	214	136	2	0.000204	1.000	1.000
113	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(78), C7orf16(1), CACNA1A(22), CRH(2), CRHR1(2), GNA11(6), GNA12(2), GNA13(1), GNAI1(1), GNAI2(3), GNAO1(2), GNAQ(1), GNAS(12), GNAZ(4), GRIA1(33), GRIA2(22), GRIA3(19), GRID2(41), GRM1(9), GRM5(9), GUCY1A2(11), GUCY1A3(20), GUCY1B3(4), GUCY2C(20), GUCY2D(3), GUCY2F(10), HRAS(1), IGF1(7), IGF1R(6), ITPR1(19), ITPR2(10), ITPR3(4), KRAS(1), LYN(3), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), NOS1(38), NOS3(13), NPR1(13), NPR2(12), NRAS(39), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(3), PPP2R2C(4), PRKCA(8), PRKCG(10), PRKG1(7), PRKG2(10), RAF1(2), RYR1(61)	21821592	758	128	622	385	507	37	28	139	47	0	0.00312	1.000	1.000
114	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BRAF(78), CASP3(1), CD244(7), CD247(2), CD48(4), CHP(1), CSF2(2), FAS(3), FASLG(10), FCER1G(1), FCGR3A(5), FCGR3B(1), FYN(5), GRB2(2), GZMB(2), HLA-A(2), HLA-B(4), HLA-C(1), HLA-G(3), HRAS(1), ICAM1(2), ICAM2(4), IFNA10(2), IFNA14(6), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(3), IFNAR1(1), IFNAR2(5), IFNB1(5), IFNG(2), IFNGR1(3), IFNGR2(2), ITGAL(17), ITGB2(10), KIR2DL1(13), KIR2DL3(4), KIR2DL4(3), KIR3DL1(15), KIR3DL2(2), KLRC1(2), KLRC2(1), KLRC3(5), KLRD1(4), KLRK1(3), KRAS(1), LCK(9), LCP2(5), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), MICA(3), MICB(2), NCR1(10), NCR2(6), NCR3(2), NFAT5(3), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NRAS(39), PAK1(2), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PLCG1(4), PLCG2(15), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PRF1(6), PRKCA(8), PRKCG(10), PTK2B(7), PTPN11(5), PTPN6(1), RAC1(9), RAF1(2), SH2D1A(2), SH2D1B(3), SH3BP2(2), SHC1(1), SHC2(4), SHC3(9), SHC4(1), SOS1(6), SOS2(3), SYK(11), TNF(1), TNFRSF10A(4), TNFRSF10B(1), TNFRSF10C(4), TNFRSF10D(6), TNFSF10(5), TYROBP(2), ULBP1(2), ULBP3(5), VAV1(13), VAV2(3), VAV3(6), ZAP70(4)	22580021	616	127	504	248	387	42	27	129	31	0	0.000163	1.000	1.000
115	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(17), ADCY8(30), ATF4(4), BRAF(78), CACNA1C(30), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(9), CHP(1), CREBBP(14), EP300(8), GNAQ(1), GRIA1(33), GRIA2(22), GRIN1(6), GRIN2A(57), GRIN2B(32), GRIN2C(7), GRIN2D(4), GRM1(9), GRM5(9), HRAS(1), ITPR1(19), ITPR2(10), ITPR3(4), KRAS(1), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), NRAS(39), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R12A(3), PPP1R1A(3), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PRKACA(2), PRKACB(2), PRKACG(7), PRKCA(8), PRKCG(10), PRKX(1), RAF1(2), RAP1A(1), RAPGEF3(4), RPS6KA1(4), RPS6KA2(4), RPS6KA6(5)	19660533	631	126	511	320	399	40	28	129	35	0	0.0349	1.000	1.000
116	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(16), ACACB(14), AKT1(1), AKT2(6), AKT3(3), BRAF(78), CALM2(1), CALML3(3), CBL(6), CBLB(8), CBLC(12), CRK(2), ELK1(1), EXOC7(5), FASN(9), FBP1(1), FBP2(1), FLOT1(1), FOXO1(4), G6PC(4), G6PC2(2), GCK(10), GRB2(2), GSK3B(2), GYS1(2), GYS2(10), HRAS(1), IKBKB(2), INPP5D(22), INSR(13), IRS1(3), IRS2(1), IRS4(7), KRAS(1), LIPE(6), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK10(6), MAPK3(1), MAPK9(1), MKNK1(5), MKNK2(2), NRAS(39), PCK1(20), PCK2(3), PDE3A(14), PDE3B(5), PDPK1(3), PFKL(2), PHKA1(13), PHKA2(6), PHKB(5), PHKG1(1), PHKG2(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PKLR(6), PKM2(5), PPARGC1A(15), PPP1CA(1), PPP1CB(3), PPP1CC(1), PPP1R3A(45), PPP1R3B(2), PPP1R3C(2), PPP1R3D(2), PRKAA1(1), PRKAA2(18), PRKAB2(1), PRKACA(2), PRKACB(2), PRKACG(7), PRKAG1(2), PRKAG2(3), PRKAG3(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCI(5), PRKCZ(1), PRKX(1), PTPN1(2), PTPRF(19), PYGB(2), PYGL(4), PYGM(7), RAF1(2), RAPGEF1(4), RPS6(1), RPS6KB1(2), RPS6KB2(2), SH2B2(3), SHC1(1), SHC2(4), SHC3(9), SHC4(1), SLC2A4(6), SOCS2(1), SOCS3(2), SOCS4(2), SORBS1(8), SOS1(6), SOS2(3), SREBF1(3), TRIP10(2), TSC1(3), TSC2(7)	31974461	690	126	579	279	429	42	36	139	44	0	5.40e-05	1.000	1.000
117	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(3), ABL2(6), AKT1(1), AKT2(6), AKT3(3), AREG(7), BRAF(78), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CBL(6), CBLB(8), CBLC(12), CDKN1A(2), CDKN1B(1), CRK(2), EGF(14), EGFR(16), ELK1(1), ERBB2(3), ERBB3(2), ERBB4(30), GAB1(3), GRB2(2), GSK3B(2), HRAS(1), JUN(1), KRAS(1), MAP2K1(7), MAP2K2(2), MAP2K4(3), MAP2K7(2), MAPK1(3), MAPK10(6), MAPK3(1), MAPK9(1), MYC(2), NCK2(3), NRAS(39), NRG1(11), NRG2(5), NRG3(14), NRG4(1), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PLCG1(4), PLCG2(15), PRKCA(8), PRKCG(10), PTK2(3), RAF1(2), RPS6KB1(2), RPS6KB2(2), SHC1(1), SHC2(4), SHC3(9), SHC4(1), SOS1(6), SOS2(3), SRC(1), STAT5A(2), STAT5B(4), TGFA(1)	20524739	494	125	383	191	283	28	34	129	20	0	0.00490	1.000	1.000
118	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(12), ADORA1(5), ADORA2A(2), ADORA2B(1), ADORA3(10), ADRA1A(5), ADRA1B(2), ADRA2A(3), ADRA2B(5), ADRA2C(2), ADRB1(5), ADRB2(1), AGTR1(7), AGTR2(3), AVPR1A(3), AVPR1B(5), BDKRB1(5), BDKRB2(2), BRS3(2), C3AR1(3), C5AR1(6), CALCR(13), CALCRL(8), CCKAR(9), CCKBR(8), CHRM1(4), CHRM2(10), CHRM3(11), CHRM4(5), CHRM5(2), CNR1(7), CNR2(1), CRHR1(2), CRHR2(1), CTSG(4), CYSLTR1(3), CYSLTR2(2), DRD1(8), DRD2(9), DRD3(1), DRD4(1), DRD5(18), EDNRA(4), EDNRB(4), F2(6), F2R(4), F2RL1(10), F2RL2(4), FPR1(15), FSHB(2), FSHR(12), GABBR1(4), GABBR2(8), GABRA1(8), GABRA2(10), GABRA3(14), GABRA4(6), GABRA5(2), GABRA6(17), GABRB1(11), GABRB2(9), GABRB3(13), GABRD(5), GABRE(14), GABRG1(16), GABRG2(8), GABRG3(6), GABRP(9), GABRQ(4), GABRR1(6), GALR1(3), GH1(1), GH2(10), GHR(16), GHRHR(4), GHSR(6), GIPR(2), GLP1R(5), GLP2R(7), GLRA1(7), GLRA2(4), GLRA3(8), GLRB(14), GNRHR(2), GPR156(5), GPR35(2), GPR50(13), GPR63(4), GPR83(7), GRIA1(33), GRIA2(22), GRIA3(19), GRIA4(14), GRID1(17), GRID2(41), GRIK1(14), GRIK2(17), GRIK3(19), GRIK4(7), GRIK5(8), GRIN1(6), GRIN2A(57), GRIN2B(32), GRIN2C(7), GRIN2D(4), GRIN3A(29), GRIN3B(3), GRM1(9), GRM2(3), GRM3(39), GRM4(15), GRM5(9), GRM6(16), GRM7(21), GRM8(28), GRPR(3), GZMA(10), HCRTR1(1), HCRTR2(18), HRH1(11), HRH2(3), HRH3(4), HRH4(4), HTR1A(7), HTR1D(3), HTR1E(3), HTR1F(5), HTR2A(7), HTR2C(6), HTR4(5), HTR5A(11), HTR6(1), HTR7(7), LEP(1), LEPR(13), LHCGR(14), MAS1(2), MC2R(3), MC3R(6), MC4R(1), MC5R(5), MCHR1(3), MCHR2(8), MLNR(1), MTNR1A(6), MTNR1B(5), NMBR(3), NMUR1(4), NMUR2(12), NPBWR1(1), NPBWR2(6), NPFFR2(6), NPY1R(12), NPY2R(8), NPY5R(12), NR3C1(2), NTSR1(4), NTSR2(2), OPRK1(15), OPRL1(5), OPRM1(4), OXTR(3), P2RX1(2), P2RX2(1), P2RX3(5), P2RX4(2), P2RX5(6), P2RX7(3), P2RY1(2), P2RY10(6), P2RY13(3), P2RY14(5), P2RY2(5), P2RY6(1), P2RY8(4), PARD3(10), PPYR1(10), PRL(1), PRLHR(1), PRLR(22), PRSS1(11), PRSS3(2), PTAFR(1), PTGDR(7), PTGER2(5), PTGER3(2), PTGFR(13), PTGIR(3), PTH2R(9), RXFP1(10), RXFP2(12), SCTR(5), SSTR1(7), SSTR2(2), SSTR3(10), SSTR4(1), SSTR5(3), TAAR1(2), TAAR2(8), TAAR5(1), TAAR6(5), TAAR8(4), TAAR9(3), TACR1(5), TACR2(3), TACR3(17), TBXA2R(3), THRA(1), THRB(12), TRHR(13), TRPV1(2), TSHB(3), TSHR(7), UTS2R(1), VIPR1(3), VIPR2(4)	43917795	1621	125	1547	1057	1201	128	40	122	129	1	2.09e-05	1.000	1.000
119	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(4), ACTG1(4), CHAD(3), COL11A1(38), COL11A2(26), COL17A1(17), COL1A1(28), COL1A2(31), COL2A1(18), COL3A1(44), COL4A1(33), COL4A2(20), COL4A4(58), COL4A6(28), COL5A1(43), COL5A2(28), COL5A3(46), COL6A1(7), COL6A2(7), COL6A3(36), COL6A6(33), COMP(5), DES(5), DSC1(29), DSC2(29), DSC3(24), DSG1(38), DSG2(15), DSG3(40), DSG4(41), FN1(10), GJA1(6), GJA10(12), GJA3(1), GJA4(3), GJA5(5), GJA8(14), GJA9(3), GJB2(3), GJB3(2), GJB4(5), GJB5(4), GJB6(4), GJB7(1), GJC1(5), GJC3(1), GJD2(1), IBSP(6), INA(3), ITGA6(6), ITGB4(12), KRT1(12), KRT10(10), KRT12(8), KRT13(5), KRT14(1), KRT15(3), KRT16(7), KRT17(7), KRT18(2), KRT2(11), KRT20(6), KRT23(3), KRT24(4), KRT25(7), KRT27(3), KRT28(6), KRT3(7), KRT31(3), KRT32(10), KRT33A(5), KRT33B(2), KRT34(8), KRT35(6), KRT36(11), KRT37(6), KRT38(6), KRT39(9), KRT4(10), KRT40(4), KRT5(10), KRT6A(10), KRT6B(3), KRT6C(7), KRT7(3), KRT71(9), KRT72(6), KRT73(9), KRT74(7), KRT75(10), KRT76(8), KRT77(12), KRT78(15), KRT79(6), KRT8(2), KRT81(3), KRT82(5), KRT83(9), KRT84(6), KRT85(2), KRT86(6), KRT9(12), LAMA1(30), LAMA2(31), LAMA3(38), LAMA4(4), LAMA5(20), LAMB1(7), LAMB2(6), LAMB3(18), LAMB4(23), LAMC1(9), LAMC2(15), LAMC3(6), LMNA(3), LMNB1(1), LMNB2(4), NES(15), RELN(46), SPP1(4), THBS1(19), THBS2(8), THBS3(7), THBS4(7), TNC(20), TNN(32), TNR(46), TNXB(78), VIM(3), VTN(7), VWF(32)	50032725	1766	122	1720	784	1377	128	35	108	117	1	2.63e-06	1.000	1.000
120	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(8), CD36(3), CD44(5), CD47(1), CHAD(3), COL11A1(38), COL11A2(26), COL1A1(28), COL1A2(31), COL2A1(18), COL3A1(44), COL4A1(33), COL4A2(20), COL4A4(58), COL4A6(28), COL5A1(43), COL5A2(28), COL5A3(46), COL6A1(7), COL6A2(7), COL6A3(36), COL6A6(33), DAG1(3), FN1(10), FNDC1(27), FNDC3A(8), FNDC4(5), FNDC5(2), GP5(2), GP6(5), GP9(5), HMMR(4), HSPG2(19), IBSP(6), ITGA1(15), ITGA10(4), ITGA11(13), ITGA2(7), ITGA2B(7), ITGA3(4), ITGA4(26), ITGA5(13), ITGA6(6), ITGA7(15), ITGA8(26), ITGA9(9), ITGAV(5), ITGB1(4), ITGB3(9), ITGB4(12), ITGB5(1), ITGB6(8), ITGB7(4), ITGB8(10), LAMA1(30), LAMA2(31), LAMA3(38), LAMA4(4), LAMA5(20), LAMB1(7), LAMB2(6), LAMB3(18), LAMB4(23), LAMC1(9), LAMC2(15), LAMC3(6), RELN(46), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SPP1(4), SV2A(15), SV2B(23), SV2C(9), THBS1(19), THBS2(8), THBS3(7), THBS4(7), TNC(20), TNN(32), TNR(46), TNXB(78), VTN(7), VWF(32)	44864342	1405	121	1376	638	1085	80	43	100	96	1	0.0480	1.000	1.000
121	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY7(8), ADCY8(30), ADCY9(9), ADORA2A(2), ADORA2B(1), ADRA1A(5), ADRA1B(2), ADRA1D(4), ADRB1(5), ADRB2(1), AGTR1(7), ATP2A1(6), ATP2A2(5), ATP2A3(7), ATP2B1(3), ATP2B2(15), ATP2B3(6), ATP2B4(8), AVPR1A(3), AVPR1B(5), BDKRB1(5), BDKRB2(2), CACNA1A(22), CACNA1B(20), CACNA1C(30), CACNA1D(23), CACNA1E(71), CACNA1F(15), CACNA1G(23), CACNA1H(17), CACNA1I(21), CACNA1S(30), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(9), CCKAR(9), CCKBR(8), CD38(3), CHP(1), CHRM1(4), CHRM2(10), CHRM3(11), CHRM5(2), CHRNA7(2), CYSLTR1(3), CYSLTR2(2), DRD1(8), EDNRA(4), EDNRB(4), EGFR(16), ERBB2(3), ERBB3(2), ERBB4(30), F2R(4), GNA11(6), GNA14(4), GNA15(2), GNAL(2), GNAQ(1), GNAS(12), GRIN1(6), GRIN2A(57), GRIN2C(7), GRIN2D(4), GRM1(9), GRM5(9), GRPR(3), HRH1(11), HRH2(3), HTR2A(7), HTR2C(6), HTR4(5), HTR5A(11), HTR6(1), HTR7(7), ITPKB(5), ITPR1(19), ITPR2(10), ITPR3(4), LHCGR(14), MYLK(22), MYLK2(6), NOS1(38), NOS3(13), NTSR1(4), OXTR(3), P2RX1(2), P2RX2(1), P2RX3(5), P2RX4(2), P2RX5(6), P2RX7(3), PDE1A(22), PDE1B(8), PDE1C(25), PDGFRA(15), PDGFRB(10), PHKA1(13), PHKA2(6), PHKB(5), PHKG1(1), PHKG2(1), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PLCD1(2), PLCD3(2), PLCD4(1), PLCE1(27), PLCG1(4), PLCG2(15), PLCZ1(13), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PRKACA(2), PRKACB(2), PRKACG(7), PRKCA(8), PRKCG(10), PRKX(1), PTAFR(1), PTGER3(2), PTGFR(13), PTK2B(7), RYR1(61), RYR2(54), RYR3(48), SLC25A6(2), SLC8A1(14), SLC8A2(5), SLC8A3(20), SPHK1(1), SPHK2(5), TACR1(5), TACR2(3), TACR3(17), TBXA2R(3), TNNC2(2), TRHR(13), TRPC1(3), VDAC1(1), VDAC2(1), VDAC3(1)	53166145	1497	120	1442	1038	1114	101	51	108	120	3	0.253	1.000	1.000
122	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(1), ACVR1B(3), ACVR2A(3), ACVR2B(1), AMHR2(9), BMP2(4), BMP7(2), BMPR1A(1), BMPR1B(2), BMPR2(4), CCL11(1), CCL14(2), CCL15(2), CCL16(1), CCL18(1), CCL2(1), CCL21(2), CCL24(1), CCL25(1), CCL28(1), CCL7(4), CCL8(3), CCR1(5), CCR2(8), CCR3(8), CCR4(5), CCR5(5), CCR6(1), CCR7(3), CCR8(2), CCR9(3), CD27(2), CD40(1), CD40LG(2), CLCF1(1), CNTFR(3), CSF1(8), CSF1R(9), CSF2(2), CSF2RA(11), CSF2RB(14), CSF3(2), CSF3R(6), CX3CL1(2), CX3CR1(10), CXCL10(2), CXCL11(1), CXCL12(1), CXCL14(1), CXCL3(1), CXCL5(2), CXCL9(2), CXCR3(2), CXCR4(1), CXCR6(4), EDA(1), EDA2R(3), EDAR(4), EGF(14), EGFR(16), EPO(4), EPOR(1), FAS(3), FASLG(10), FLT1(21), FLT3(21), FLT3LG(1), FLT4(19), GDF5(9), GH1(1), GH2(10), GHR(16), HGF(13), IFNA10(2), IFNA14(6), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(3), IFNAR1(1), IFNAR2(5), IFNB1(5), IFNG(2), IFNGR1(3), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(4), IL11(2), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(9), IL12RB2(3), IL13(2), IL13RA1(3), IL15(1), IL15RA(4), IL17A(7), IL17RA(4), IL17RB(1), IL18(2), IL18R1(14), IL18RAP(13), IL19(2), IL1A(3), IL1B(5), IL1R1(7), IL1R2(5), IL1RAP(3), IL2(4), IL20(3), IL20RA(8), IL21(2), IL21R(11), IL22(1), IL22RA1(6), IL22RA2(1), IL23A(1), IL23R(2), IL25(1), IL26(2), IL28A(1), IL28B(2), IL28RA(4), IL29(1), IL2RA(4), IL2RB(7), IL2RG(2), IL3(2), IL3RA(4), IL4(1), IL4R(7), IL5(4), IL5RA(7), IL6R(2), IL6ST(6), IL7(3), IL7R(15), IL8(1), IL9R(4), INHBA(12), INHBB(4), INHBC(6), INHBE(2), KDR(25), KIT(7), KITLG(6), LEP(1), LEPR(13), LIF(1), LIFR(14), LTA(2), LTB(1), MET(12), MPL(2), NGFR(6), OSM(2), OSMR(28), PDGFB(2), PDGFC(14), PDGFRA(15), PDGFRB(10), PLEKHO2(5), PPBP(3), PRL(1), PRLR(22), RELT(1), TGFB2(1), TGFB3(1), TGFBR2(5), TNF(1), TNFRSF10A(4), TNFRSF10B(1), TNFRSF10C(4), TNFRSF10D(6), TNFRSF11A(5), TNFRSF11B(9), TNFRSF13B(7), TNFRSF14(2), TNFRSF17(4), TNFRSF18(3), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(7), TNFRSF25(4), TNFRSF4(4), TNFRSF6B(2), TNFRSF8(11), TNFRSF9(3), TNFSF10(5), TNFSF11(4), TNFSF12(1), TNFSF14(6), TNFSF15(7), TNFSF18(5), TNFSF4(3), TNFSF8(2), TNFSF9(1), TPO(30), TSLP(1), VEGFA(1), VEGFB(1), VEGFC(14), XCL1(1), XCL2(2), XCR1(3)	35363323	1018	120	987	582	766	71	19	65	97	0	0.106	1.000	1.000
123	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(78), CPEB1(5), EGFR(16), ERBB2(3), ERBB4(30), ETS1(3), ETS2(8), ETV6(8), ETV7(2), FMN2(50), GRB2(2), KRAS(1), MAP2K1(7), MAPK1(3), MAPK3(1), NOTCH1(4), NOTCH2(25), NOTCH3(16), NOTCH4(38), PIWIL1(17), PIWIL2(8), PIWIL3(11), PIWIL4(3), RAF1(2), SOS1(6), SOS2(3), SPIRE2(3)	10513489	353	119	282	125	208	20	7	103	15	0	0.0134	1.000	1.000
124	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(3), ACTN1(2), ACTR2(2), AKT1(1), AKT2(6), AKT3(3), ANGPTL2(2), ARHGEF6(5), ARHGEF7(2), BCAR1(3), BRAF(78), CAV1(1), CDKN2A(23), CRK(2), CSE1L(4), DOCK1(13), EPHB2(17), FYN(5), GRB2(2), GRB7(5), GRLF1(3), ITGA1(15), ITGA10(4), ITGA11(13), ITGA2(7), ITGA3(4), ITGA4(26), ITGA5(13), ITGA6(6), ITGA7(15), ITGA8(26), ITGA9(9), MAP2K4(3), MAP2K7(2), MAP3K11(4), MAPK1(3), MAPK10(6), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(6), MAPK9(1), MRAS(1), MYLK(22), MYLK2(6), P4HB(2), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PIK3CA(2), PIK3CB(10), PKLR(6), PLCG1(4), PLCG2(15), PTEN(12), PTK2(3), RAF1(2), RHO(2), ROCK1(3), ROCK2(4), SHC1(1), SOS1(6), SOS2(3), SRC(1), TLN1(10), TLN2(15), VASP(1), WAS(5), ZYX(4)	24337206	540	117	458	231	322	30	19	114	55	0	0.00644	1.000	1.000
125	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(3), ABLIM1(9), ABLIM2(2), ABLIM3(4), ARHGEF12(6), CDK5(3), CFL1(1), CHP(1), CXCL12(1), CXCR4(1), DCC(54), DPYSL2(4), DPYSL5(9), EFNA4(1), EFNA5(2), EFNB1(1), EFNB3(1), EPHA1(7), EPHA2(8), EPHA3(16), EPHA4(11), EPHA5(6), EPHA6(40), EPHA7(29), EPHA8(11), EPHB1(17), EPHB2(17), EPHB3(11), EPHB4(3), EPHB6(14), FES(4), FYN(5), GNAI1(1), GNAI2(3), GSK3B(2), HRAS(1), ITGB1(4), KRAS(1), L1CAM(5), LIMK1(4), LIMK2(6), LRRC4C(23), MAPK1(3), MAPK3(1), MET(12), NCK2(3), NFAT5(3), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NGEF(8), NRAS(39), NRP1(14), NTN4(13), NTNG1(7), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PLXNA1(7), PLXNA2(7), PLXNA3(5), PLXNB1(16), PLXNB2(8), PLXNB3(3), PLXNC1(12), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PTK2(3), RAC1(9), RASA1(1), RGS3(8), RHOD(1), RND1(4), ROBO1(14), ROBO2(24), ROBO3(10), ROCK1(3), ROCK2(4), SEMA3A(10), SEMA3B(2), SEMA3C(2), SEMA3D(9), SEMA3E(14), SEMA3F(6), SEMA3G(8), SEMA4A(5), SEMA4B(4), SEMA4C(4), SEMA4D(6), SEMA4F(5), SEMA4G(5), SEMA5A(10), SEMA5B(10), SEMA6A(5), SEMA6B(5), SEMA6C(6), SEMA6D(3), SEMA7A(3), SLIT1(11), SLIT2(39), SLIT3(34), SRGAP2(2), SRGAP3(22), UNC5A(7), UNC5B(8), UNC5C(11), UNC5D(15)	38938465	955	115	887	495	683	66	32	101	71	2	0.0128	1.000	1.000
126	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(3), ACTA2(3), ACTN2(14), ACTN3(5), ACTN4(3), DES(5), DMD(18), MYBPC1(12), MYBPC2(10), MYBPC3(7), MYH3(15), MYH6(19), MYH7(29), MYH8(35), MYL1(9), MYL2(4), MYL3(2), MYL4(5), MYL9(1), MYOM1(14), NEB(81), TCAP(1), TNNC2(2), TNNI1(1), TNNI2(1), TNNI3(1), TNNT1(3), TNNT2(2), TNNT3(3), TPM2(2), TPM3(2), TPM4(1), TTN(717), VIM(3)	26445892	1033	115	977	440	789	70	35	79	51	9	4.36e-06	1.000	1.000
127	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADCY9(9), ADRA1A(5), ADRA1B(2), ADRA1D(4), ADRB1(5), ADRB2(1), ANXA6(3), ARRB1(2), ARRB2(3), ATP1A4(9), ATP1B1(1), ATP2A2(5), ATP2A3(7), ATP2B1(3), ATP2B2(15), ATP2B3(6), CACNA1A(22), CACNA1B(20), CACNA1C(30), CACNA1D(23), CACNA1E(71), CACNA1S(30), CACNB1(2), CACNB3(2), CALM2(1), CAMK1(4), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(9), CASQ1(6), CASQ2(3), CHRM1(4), CHRM2(10), CHRM3(11), CHRM4(5), CHRM5(2), GJA1(6), GJA4(3), GJA5(5), GJB2(3), GJB3(2), GJB4(5), GJB5(4), GJB6(4), GNA11(6), GNAI2(3), GNAO1(2), GNAQ(1), GNAZ(4), GNB3(5), GNB4(1), GNB5(2), GNG2(3), GNG4(2), GNG7(2), GRK4(6), GRK5(3), GRK6(1), ITPR1(19), ITPR2(10), ITPR3(4), KCNB1(18), KCNJ3(14), KCNJ5(6), MIB1(4), NME7(4), PKIA(1), PKIB(1), PKIG(1), PLCB3(2), PRKACA(2), PRKACB(2), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), PRKCD(2), PRKCE(4), PRKCG(10), PRKCH(5), PRKCQ(12), PRKCZ(1), PRKD1(2), RGS1(3), RGS11(2), RGS14(3), RGS16(1), RGS18(7), RGS20(1), RGS3(8), RGS4(2), RGS5(2), RGS6(10), RGS7(26), RGS9(9), RYR1(61), RYR2(54), RYR3(48), SFN(1), SLC8A1(14), SLC8A3(20), USP5(3), YWHAQ(2)	37175699	917	114	879	647	666	81	30	64	73	3	0.507	1.000	1.000
128	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(1), AKT2(6), AKT3(3), CBL(6), CBLB(8), CBLC(12), CCND1(1), CCND2(4), CCND3(1), CISH(2), CLCF1(1), CNTFR(3), CREBBP(14), CSF2(2), CSF2RA(11), CSF2RB(14), CSF3(2), CSF3R(6), EP300(8), EPO(4), EPOR(1), GH1(1), GH2(10), GHR(16), GRB2(2), IFNA10(2), IFNA14(6), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(3), IFNAR1(1), IFNAR2(5), IFNB1(5), IFNG(2), IFNGR1(3), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(4), IL11(2), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(9), IL12RB2(3), IL13(2), IL13RA1(3), IL13RA2(2), IL15(1), IL15RA(4), IL19(2), IL2(4), IL20(3), IL20RA(8), IL21(2), IL21R(11), IL22(1), IL22RA1(6), IL22RA2(1), IL23A(1), IL23R(2), IL26(2), IL28A(1), IL28B(2), IL28RA(4), IL29(1), IL2RA(4), IL2RB(7), IL2RG(2), IL3(2), IL3RA(4), IL4(1), IL4R(7), IL5(4), IL5RA(7), IL6R(2), IL6ST(6), IL7(3), IL7R(15), IL9R(4), IRF9(1), JAK1(4), JAK2(6), JAK3(5), LEP(1), LEPR(13), LIF(1), LIFR(14), MPL(2), MYC(2), OSM(2), OSMR(28), PIAS1(2), PIAS2(4), PIAS3(3), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PIM1(1), PRL(1), PRLR(22), PTPN11(5), PTPN6(1), SOCS2(1), SOCS3(2), SOCS4(2), SOCS5(4), SOCS7(3), SOS1(6), SOS2(3), SPRED1(3), SPRED2(1), SPRY1(6), SPRY2(3), SPRY3(7), SPRY4(1), STAM(2), STAT1(2), STAT2(6), STAT3(6), STAT4(13), STAT5A(2), STAT5B(4), STAT6(5), TPO(30), TSLP(1), TYK2(4)	29135844	635	114	621	332	456	49	21	53	56	0	0.270	1.000	1.000
129	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(12), APC2(4), AXIN1(6), AXIN2(2), BTRC(4), CACYBP(1), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CCND1(1), CCND2(4), CCND3(1), CER1(7), CHD8(14), CHP(1), CREBBP(14), CSNK1A1(2), CSNK1A1L(3), CSNK1E(3), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTBP2(1), CTNNB1(6), CTNNBIP1(1), CUL1(4), DAAM1(3), DAAM2(2), DKK1(1), DKK2(9), DKK4(1), DVL2(3), DVL3(5), EP300(8), FBXW11(4), FZD1(1), FZD10(1), FZD2(4), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(3), GSK3B(2), JUN(1), LEF1(1), LRP5(13), LRP6(13), MAPK10(6), MAPK9(1), MMP7(3), MYC(2), NFAT5(3), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NKD1(5), NKD2(4), NLK(4), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PORCN(3), PPARD(2), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(3), PPP2R2C(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PRICKLE1(5), PRICKLE2(3), PRKACA(2), PRKACB(2), PRKACG(7), PRKCA(8), PRKCG(10), PRKX(1), PSEN1(1), RAC1(9), ROCK1(3), ROCK2(4), SENP2(9), SFRP2(8), SFRP4(4), SMAD2(1), SOX17(3), TBL1X(1), TBL1XR1(1), TBL1Y(4), TCF7(1), TCF7L1(1), TCF7L2(4), TP53(26), VANGL1(1), VANGL2(6), WIF1(5), WNT1(1), WNT10A(4), WNT10B(4), WNT11(2), WNT16(1), WNT2(6), WNT2B(2), WNT3(4), WNT3A(5), WNT4(2), WNT5A(5), WNT5B(2), WNT6(2), WNT7A(10), WNT7B(2), WNT8A(4), WNT8B(5), WNT9A(1), WNT9B(3)	32114105	557	113	534	264	374	41	23	66	53	0	0.0401	1.000	1.000
130	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(3), ACTA2(3), ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADCY9(9), ARRB1(2), ARRB2(3), ATF1(3), ATF2(5), ATF4(4), ATF5(3), ATP2A2(5), ATP2A3(7), CACNB3(2), CALM2(1), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CNN1(2), CNN2(2), CORIN(19), CRH(2), CRHR1(2), DGKZ(6), ETS2(8), FOS(1), GABPB2(5), GBA2(2), GJA1(6), GNAQ(1), GNB3(5), GNB4(1), GNB5(2), GNG2(3), GNG4(2), GNG7(2), GRK4(6), GRK5(3), GRK6(1), GSTO1(2), GUCY1A3(20), IGFBP1(2), IGFBP2(2), IGFBP3(1), IGFBP6(2), IL1B(5), ITPR1(19), ITPR2(10), ITPR3(4), JUN(1), MIB1(4), MYL2(4), MYL4(5), MYLK2(6), NFKB1(3), NOS1(38), NOS3(13), OXTR(3), PDE4B(6), PDE4D(5), PKIA(1), PKIB(1), PKIG(1), PLCB3(2), PLCD1(2), PLCG1(4), PLCG2(15), PRKACA(2), PRKACB(2), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), PRKCD(2), PRKCE(4), PRKCH(5), PRKCQ(12), PRKCZ(1), PRKD1(2), RAMP1(1), RAMP3(1), RGS1(3), RGS11(2), RGS14(3), RGS16(1), RGS18(7), RGS20(1), RGS3(8), RGS4(2), RGS5(2), RGS6(10), RGS7(26), RGS9(9), RLN1(3), RYR1(61), RYR2(54), RYR3(48), SFN(1), SLC8A1(14), SP1(4), TNXB(78), USP5(3), YWHAQ(2)	34765708	794	113	766	487	592	62	22	57	58	3	0.0934	1.000	1.000
131	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(5), ADORA2A(2), ADORA2B(1), ADORA3(10), ADRA1A(5), ADRA1B(2), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(1), AGTR1(7), AGTR2(3), AVPR1A(3), AVPR1B(5), BDKRB1(5), BDKRB2(2), BRS3(2), C3AR1(3), CCBP2(6), CCKAR(9), CCKBR(8), CCR1(5), CCR10(2), CCR2(8), CCR3(8), CCR4(5), CCR5(5), CCR6(1), CCR7(3), CCR8(2), CCR9(3), CCRL2(2), CHML(2), CHRM1(4), CHRM2(10), CHRM3(11), CHRM4(5), CHRM5(2), CMKLR1(10), CNR1(7), CNR2(1), CX3CR1(10), CXCR3(2), CXCR4(1), DRD1(8), DRD2(9), DRD3(1), DRD4(1), DRD5(18), EDNRA(4), EDNRB(4), F2R(4), F2RL1(10), F2RL2(4), FPR1(15), FSHR(12), GALR1(3), GALT(2), GHSR(6), GNB2L1(2), GPR17(1), GPR173(1), GPR174(8), GPR27(2), GPR3(2), GPR35(2), GPR37(4), GPR37L1(4), GPR4(3), GPR50(13), GPR6(5), GPR63(4), GPR77(3), GPR83(7), GPR85(4), GPR87(3), GRPR(3), HCRTR1(1), HCRTR2(18), HRH1(11), HRH2(3), HRH3(4), HTR1A(7), HTR1D(3), HTR1E(3), HTR1F(5), HTR2A(7), HTR2C(6), HTR4(5), HTR5A(11), HTR6(1), HTR7(7), LHCGR(14), MAS1(2), MC3R(6), MC4R(1), MC5R(5), MLNR(1), MTNR1A(6), MTNR1B(5), NMBR(3), NMUR1(4), NMUR2(12), NPY1R(12), NPY2R(8), NPY5R(12), NTSR1(4), NTSR2(2), OPN1SW(2), OPN3(2), OPRK1(15), OPRL1(5), OPRM1(4), OR10A5(4), OR11A1(2), OR12D3(5), OR1C1(7), OR1F1(3), OR1Q1(4), OR2H1(4), OR5V1(7), OR7A5(1), OR7C1(1), OR8B8(7), OXTR(3), P2RY1(2), P2RY10(6), P2RY12(2), P2RY13(3), P2RY14(5), P2RY2(5), P2RY6(1), PPYR1(10), PTAFR(1), PTGDR(7), PTGER2(5), PTGFR(13), PTGIR(3), RGR(3), RHO(2), SSTR1(7), SSTR2(2), SSTR3(10), SSTR4(1), SUCNR1(7), TBXA2R(3), TRHR(13)	24216560	750	111	724	606	526	78	23	70	53	0	0.0703	1.000	1.000
132	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(4), ACTG1(4), ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(3), AKT1(1), AKT2(6), AKT3(3), AMOTL1(2), ASH1L(21), CASK(2), CDK4(2), CGN(6), CLDN1(5), CLDN10(3), CLDN11(3), CLDN14(5), CLDN16(4), CLDN17(3), CLDN18(6), CLDN19(2), CLDN2(4), CLDN20(1), CLDN22(1), CLDN4(7), CLDN6(6), CLDN7(1), CLDN8(2), CLDN9(1), CSDA(2), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(17), CTNNA3(19), CTNNB1(6), CTTN(1), EPB41(5), EPB41L1(7), EPB41L2(10), EPB41L3(6), EXOC3(2), EXOC4(5), F11R(4), GNAI1(1), GNAI2(3), HCLS1(7), HRAS(1), IGSF5(6), INADL(31), JAM2(9), JAM3(1), KRAS(1), LLGL1(2), LLGL2(10), MAGI1(19), MAGI2(16), MAGI3(9), MLLT4(9), MPDZ(8), MRAS(1), MYH1(54), MYH10(6), MYH11(23), MYH13(22), MYH14(14), MYH15(34), MYH2(53), MYH3(15), MYH4(46), MYH6(19), MYH7(29), MYH7B(22), MYH8(35), MYH9(6), MYL2(4), MYL5(1), MYL9(1), MYLPF(1), NRAS(39), OCLN(2), PARD3(10), PARD6B(1), PARD6G(2), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(3), PPP2R2C(4), PPP2R3A(2), PPP2R3B(3), PPP2R4(1), PRKCA(8), PRKCD(2), PRKCE(4), PRKCG(10), PRKCH(5), PRKCI(5), PRKCQ(12), PRKCZ(1), PTEN(12), RRAS(1), SPTAN1(4), SRC(1), SYMPK(2), TJAP1(2), TJP1(9), TJP2(5), TJP3(13), YES1(3), ZAK(5)	38662530	917	111	853	601	626	76	41	91	80	3	0.842	1.000	1.000
133	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(5), BRAF(78), CHUK(1), DAXX(5), ELK1(1), FOS(1), GRB2(2), HRAS(1), IKBKB(2), JUN(1), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K5(2), MAP2K6(2), MAP2K7(2), MAP3K10(5), MAP3K11(4), MAP3K12(3), MAP3K13(5), MAP3K14(1), MAP3K2(4), MAP3K3(4), MAP3K4(11), MAP3K5(11), MAP3K6(6), MAP3K9(17), MAP4K1(6), MAP4K2(4), MAP4K3(5), MAP4K4(6), MAP4K5(3), MAPK1(3), MAPK10(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK3(1), MAPK4(10), MAPK6(3), MAPK7(2), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), MKNK1(5), MKNK2(2), MYC(2), NFKB1(3), NFKBIA(2), PAK1(2), PAK2(2), RAC1(9), RAF1(2), RELA(2), RIPK1(1), RPS6KA1(4), RPS6KA2(4), RPS6KA4(2), RPS6KA5(4), RPS6KB1(2), RPS6KB2(2), SHC1(1), SP1(4), STAT1(2), TGFB2(1), TGFB3(1), TRAF2(2)	18888553	322	111	253	131	174	31	13	87	17	0	0.0765	1.000	1.000
134	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), AKT2(6), AKT3(3), BRAF(78), DAG1(3), DRD2(9), EGFR(16), EPHB2(17), GRB2(2), ITPKB(5), ITPR1(19), ITPR2(10), ITPR3(4), KCNJ3(14), KCNJ5(6), KCNJ9(4), MAPK1(3), PI3(6), PIK3CB(10), PITX2(1), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), RAF1(2), RGS20(1), SHC1(1), SOS1(6), SOS2(3), SRC(1), STAT3(6)	11715797	321	111	248	152	184	24	12	83	18	0	0.118	1.000	1.000
135	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADCY9(9), ADRB1(5), CSNK1D(1), DRD1(8), DRD2(9), EGF(14), EGFR(16), GJA1(6), GJD2(1), GNA11(6), GNAI1(1), GNAI2(3), GNAQ(1), GNAS(12), GRB2(2), GRM1(9), GRM5(9), GUCY1A2(11), GUCY1A3(20), GUCY1B3(4), GUCY2C(20), GUCY2D(3), GUCY2F(10), HRAS(1), HTR2A(7), HTR2C(6), ITPR1(19), ITPR2(10), ITPR3(4), KRAS(1), MAP2K1(7), MAP2K2(2), MAP2K5(2), MAP3K2(4), MAPK1(3), MAPK3(1), MAPK7(2), NPR1(13), NPR2(12), NRAS(39), PDGFA(1), PDGFB(2), PDGFC(14), PDGFD(5), PDGFRA(15), PDGFRB(10), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PRKACA(2), PRKACB(2), PRKACG(7), PRKCA(8), PRKCG(10), PRKG1(7), PRKG2(10), PRKX(1), RAF1(2), SOS1(6), SOS2(3), SRC(1), TJP1(9), TUBA1A(1), TUBA1B(3), TUBA1C(2), TUBA3C(12), TUBA3D(9), TUBA3E(1), TUBA4A(4), TUBA8(1), TUBAL3(8), TUBB1(2), TUBB2A(2), TUBB3(3), TUBB4(1), TUBB4Q(5), TUBB6(6), TUBB8(7)	26285927	659	110	593	390	461	41	31	78	48	0	0.161	1.000	1.000
136	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADCY9(9), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CREB3L1(3), CREB3L2(5), CREB3L3(6), CREB3L4(2), CREBBP(14), CTNNB1(6), DCT(2), DVL2(3), DVL3(5), EDN1(7), EDNRB(4), EP300(8), FZD1(1), FZD10(1), FZD2(4), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(3), GNAI1(1), GNAI2(3), GNAO1(2), GNAQ(1), GNAS(12), GSK3B(2), HRAS(1), KIT(7), KITLG(6), KRAS(1), LEF1(1), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), MITF(2), NRAS(39), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), POMC(3), PRKACA(2), PRKACB(2), PRKACG(7), PRKCA(8), PRKCG(10), PRKX(1), RAF1(2), TCF7(1), TCF7L1(1), TCF7L2(4), TYR(5), TYRP1(5), WNT1(1), WNT10A(4), WNT10B(4), WNT11(2), WNT16(1), WNT2(6), WNT2B(2), WNT3(4), WNT3A(5), WNT4(2), WNT5A(5), WNT5B(2), WNT6(2), WNT7A(10), WNT7B(2), WNT8A(4), WNT8B(5), WNT9A(1), WNT9B(3)	21575449	476	110	422	263	316	32	24	65	39	0	0.117	1.000	1.000
137	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADCY9(9), ATF4(4), CACNA1C(30), CACNA1D(23), CACNA1F(15), CACNA1S(30), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), EGFR(16), ELK1(1), FSHB(2), GNA11(6), GNAQ(1), GNAS(12), GNRH2(2), GNRHR(2), GRB2(2), HRAS(1), ITPR1(19), ITPR2(10), ITPR3(4), JUN(1), KRAS(1), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAP3K2(4), MAP3K3(4), MAP3K4(11), MAPK1(3), MAPK10(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK3(1), MAPK7(2), MAPK9(1), MMP2(3), NRAS(39), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PLD1(7), PLD2(3), PRKACA(2), PRKACB(2), PRKACG(7), PRKCA(8), PRKCD(2), PRKX(1), PTK2B(7), RAF1(2), SOS1(6), SOS2(3), SRC(1)	25178670	569	109	512	354	386	45	30	66	42	0	0.430	1.000	1.000
138	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADCY9(9), AKAP1(7), AKAP10(1), AKAP11(8), AKAP12(1), AKAP3(10), AKAP4(7), AKAP6(18), AKAP7(3), AKAP8(6), AKAP9(20), ARHGEF1(1), CALM2(1), CHMP1B(1), GNA11(6), GNA12(2), GNA13(1), GNA14(4), GNA15(2), GNAI2(3), GNAL(2), GNAO1(2), GNAQ(1), GNAZ(4), GNB3(5), GNB5(2), GNG4(2), GNG7(2), GNGT2(3), HRAS(1), ITPR1(19), KCNJ3(14), KRAS(1), NRAS(39), PDE1A(22), PDE1B(8), PDE1C(25), PDE4A(3), PDE4B(6), PDE4C(11), PDE4D(5), PDE7B(12), PDE8A(2), PDE8B(12), PLCB3(2), PPP3CA(4), PPP3CC(1), PRKACA(2), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), PRKCD(2), PRKCE(4), PRKCG(10), PRKCH(5), PRKCI(5), PRKCQ(12), PRKCZ(1), PRKD1(2), PRKD3(3), RRAS(1), SLC9A1(1), USP5(3)	23372243	477	107	432	265	319	34	24	65	35	0	0.242	1.000	1.000
139	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(14), AMY2A(4), AMY2B(7), ASCC3(5), ATP13A2(7), DDX18(4), DDX19A(1), DDX23(5), DDX4(8), DDX41(4), DDX47(1), DDX50(2), DDX51(3), DDX52(3), DDX54(2), DDX55(2), DDX56(2), DHX58(4), ENPP1(9), ENPP3(10), ENTPD7(1), EP400(16), ERCC2(1), ERCC3(3), G6PC(4), G6PC2(2), GAA(5), GANC(2), GBA(2), GBA3(6), GBE1(7), GCK(10), GPI(2), GUSB(3), GYS1(2), GYS2(10), HK1(1), HK2(5), HK3(10), IFIH1(8), MGAM(89), MOV10L1(17), NUDT5(1), NUDT8(1), PGM1(2), PGM3(1), PYGB(2), PYGL(4), PYGM(7), RAD54B(5), RUVBL2(2), SETX(13), SI(44), SKIV2L2(3), SMARCA2(9), SMARCA5(3), TREH(3), UGP2(1), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2A1(12), UGT2A3(17), UGT2B10(20), UGT2B11(11), UGT2B15(18), UGT2B28(15), UGT2B4(23), UGT2B7(13), UXS1(1)	24548396	584	107	560	253	410	45	19	52	58	0	0.00111	1.000	1.000
140	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(17), BDKRB1(5), BDKRB2(2), C1QA(3), C1QB(2), C1QC(6), C1R(9), C1S(15), C2(9), C3(29), C3AR1(3), C4BPA(11), C4BPB(3), C5(9), C5AR1(6), C6(39), C7(25), C8A(27), C8B(30), C9(14), CD55(2), CD59(1), CFB(23), CFH(31), CFI(9), CR1(35), CR2(20), F10(4), F11(9), F12(1), F13A1(20), F13B(16), F2(6), F2R(4), F5(20), F7(2), F8(29), F9(6), FGA(20), FGB(7), FGG(4), KLKB1(16), KNG1(4), MASP1(6), MASP2(7), MBL2(8), PLAT(2), PLAU(2), PLAUR(1), PLG(20), PROC(7), PROS1(9), SERPINA1(7), SERPINA5(8), SERPINC1(5), SERPIND1(2), SERPINE1(2), SERPINF2(3), SERPING1(8), TFPI(5), THBD(2), VWF(32)	18052490	689	107	657	303	511	49	26	55	46	2	0.00284	1.000	1.000
141	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(2), ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADCY9(9), ADK(3), ADSL(6), ADSS(1), ADSSL1(4), AK1(1), AK2(1), AK5(6), AK7(17), ALLC(5), AMPD1(22), AMPD2(4), AMPD3(16), APRT(1), ATIC(2), CANT1(8), DGUOK(4), ENPP1(9), ENPP3(10), ENTPD1(5), ENTPD2(4), ENTPD3(3), ENTPD4(3), ENTPD5(1), ENTPD6(3), ENTPD8(1), FHIT(2), GART(7), GDA(6), GMPR2(1), GMPS(3), GUCY1A2(11), GUCY1A3(20), GUCY1B3(4), GUCY2C(20), GUCY2D(3), GUCY2F(10), GUK1(1), IMPDH2(1), NME6(1), NME7(4), NPR1(13), NPR2(12), NT5C1A(1), NT5C1B(16), NT5C2(1), NT5C3(2), NT5E(4), NT5M(1), NUDT5(1), NUDT9(2), PAPSS1(2), PAPSS2(4), PDE10A(6), PDE11A(15), PDE1A(22), PDE1C(25), PDE2A(11), PDE3B(5), PDE4A(3), PDE4B(6), PDE4C(11), PDE4D(5), PDE5A(5), PDE6D(2), PDE6G(2), PDE7B(12), PDE8A(2), PDE8B(12), PDE9A(6), PFAS(5), PKLR(6), PKM2(5), PNPT1(1), POLA1(1), POLA2(6), POLD1(3), POLD2(2), POLD3(3), POLE(10), POLE2(1), POLR1A(7), POLR1B(5), POLR1C(1), POLR2A(10), POLR2B(11), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(2), POLR3B(12), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(8), PRPS1(1), PRPS1L1(8), PRPS2(1), PRUNE(1), RRM1(3), RRM2B(1), XDH(38)	32709594	696	106	678	349	486	52	30	69	59	0	0.00503	1.000	1.000
142	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM2(1), CALML3(3), CDS1(6), CDS2(4), DGKA(1), DGKB(16), DGKD(5), DGKE(5), DGKG(10), DGKH(6), DGKI(14), DGKQ(3), DGKZ(6), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(4), INPP5A(3), INPP5B(4), INPP5D(22), INPPL1(11), ITPK1(5), ITPKB(5), ITPR1(19), ITPR2(10), ITPR3(4), OCRL(3), PI4KA(9), PI4KB(3), PIK3C2A(4), PIK3C2B(9), PIK3C2G(32), PIK3C3(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(6), PIP5K1B(15), PIP5K1C(4), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PLCD1(2), PLCD3(2), PLCD4(1), PLCE1(27), PLCG1(4), PLCG2(15), PLCZ1(13), PRKCA(8), PRKCG(10), PTEN(12), SYNJ1(11), SYNJ2(11)	24752827	510	106	490	245	373	30	20	38	49	0	0.00344	1.000	1.000
143	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(3), ANAPC1(8), ANAPC10(1), ANAPC2(3), ANAPC4(1), ANAPC5(4), ANAPC7(4), ATM(10), ATR(13), BUB1(1), BUB1B(7), CCNA1(12), CCNB2(1), CCNB3(17), CCND1(1), CCND2(4), CCND3(1), CCNE1(3), CCNE2(10), CCNH(1), CDC14A(2), CDC14B(1), CDC16(1), CDC25A(6), CDC25B(3), CDC25C(3), CDC27(6), CDC6(1), CDC7(2), CDK4(2), CDK6(1), CDKN1A(2), CDKN1B(1), CDKN2A(23), CDKN2C(1), CHEK1(1), CREBBP(14), CUL1(4), DBF4(3), E2F1(5), E2F2(3), E2F3(2), EP300(8), ESPL1(11), FZR1(3), GADD45B(1), GSK3B(2), HDAC1(1), MAD1L1(4), MAD2L2(1), MCM2(8), MCM3(7), MCM4(3), MCM5(2), MCM6(3), MDM2(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(2), ORC5L(1), ORC6L(2), PCNA(1), PKMYT1(2), PRKDC(13), PTTG1(1), PTTG2(5), RB1(3), RBL1(5), RBL2(2), SFN(1), SMAD2(1), SMC1A(2), SMC1B(9), TFDP1(1), TGFB2(1), TGFB3(1), TP53(26), WEE1(2), YWHAG(1), YWHAQ(2)	27401543	336	106	316	124	191	25	24	42	52	2	0.00332	1.000	1.000
144	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(1), AKT2(6), AKT3(3), BRAF(78), CAB39(1), EIF4B(1), FIGF(4), HIF1A(1), IGF1(7), MAPK1(3), MAPK3(1), PDPK1(3), PGF(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PRKAA1(1), PRKAA2(18), RICTOR(5), RPS6(1), RPS6KA1(4), RPS6KA2(4), RPS6KA6(5), RPS6KB1(2), RPS6KB2(2), STK11(2), TSC1(3), TSC2(7), ULK1(4), ULK2(5), ULK3(1), VEGFA(1), VEGFB(1), VEGFC(14)	10541941	235	106	170	84	117	13	9	81	15	0	0.0326	1.000	1.000
145	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(3), CADM1(1), CADM3(7), CD2(20), CD22(16), CD226(4), CD274(1), CD276(5), CD34(2), CD4(4), CD40(1), CD40LG(2), CD58(1), CD6(5), CD80(3), CD86(16), CD8A(2), CD8B(6), CD99(1), CDH1(4), CDH15(6), CDH2(10), CDH4(20), CDH5(6), CLDN1(5), CLDN10(3), CLDN11(3), CLDN14(5), CLDN16(4), CLDN17(3), CLDN18(6), CLDN19(2), CLDN2(4), CLDN20(1), CLDN22(1), CLDN4(7), CLDN6(6), CLDN7(1), CLDN8(2), CLDN9(1), CNTN1(15), CNTN2(8), CNTNAP1(7), CNTNAP2(54), CTLA4(1), ESAM(3), F11R(4), GLG1(1), HLA-A(2), HLA-B(4), HLA-C(1), HLA-DMA(2), HLA-DMB(4), HLA-DOA(4), HLA-DOB(1), HLA-DPA1(1), HLA-DQA1(4), HLA-DQA2(2), HLA-DQB1(3), HLA-DRA(7), HLA-DRB1(2), HLA-F(5), HLA-G(3), ICAM1(2), ICAM2(4), ICAM3(2), ICOS(2), ICOSLG(2), ITGA4(26), ITGA6(6), ITGA8(26), ITGA9(9), ITGAL(17), ITGAM(19), ITGAV(5), ITGB1(4), ITGB2(10), ITGB7(4), ITGB8(10), JAM2(9), JAM3(1), L1CAM(5), MADCAM1(1), MAG(11), MPZ(4), MPZL1(1), NCAM1(7), NCAM2(6), NEGR1(3), NEO1(6), NFASC(32), NLGN1(5), NLGN2(5), NLGN3(5), NRCAM(7), NRXN1(33), NRXN2(11), NRXN3(20), OCLN(2), PDCD1(3), PDCD1LG2(1), PTPRC(18), PTPRF(19), PTPRM(5), PVR(3), PVRL1(3), PVRL2(2), PVRL3(2), SDC1(1), SDC2(1), SDC3(3), SDC4(2), SELE(22), SELL(6), SELP(15), SELPLG(4), SIGLEC1(15), SPN(5), VCAM1(13), VCAN(22)	29235161	825	106	792	405	602	62	24	74	63	0	0.00135	1.000	1.000
146	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(1), ATF1(3), BRAF(78), CAMP(1), CREB5(7), CREBBP(14), DAG1(3), EGR1(1), EGR2(4), EGR3(1), EGR4(3), ELK1(1), FRS2(3), GNAQ(1), JUN(1), MAP1B(15), MAP2K4(3), MAP2K7(2), MAPK1(3), MAPK10(6), MAPK3(1), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(6), MAPK9(1), NTRK1(10), OPN1LW(3), PIK3C2G(32), PIK3CA(2), PIK3CD(2), PIK3R1(2), PTPN11(5), SHC1(1), SRC(1), TH(7)	10230910	231	106	167	88	127	12	9	74	9	0	0.0428	1.000	1.000
147	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(1), AKT2(6), AKT3(3), BCL10(1), CARD11(22), CBL(6), CBLB(8), CBLC(12), CD247(2), CD3D(5), CD3E(2), CD4(4), CD40LG(2), CD8A(2), CD8B(6), CDK4(2), CHP(1), CHUK(1), CSF2(2), CTLA4(1), FOS(1), FYN(5), GRAP2(1), GRB2(2), HRAS(1), ICOS(2), IFNG(2), IKBKB(2), IL10(2), IL2(4), IL4(1), IL5(4), ITK(19), JUN(1), KRAS(1), LCK(9), LCP2(5), MALT1(3), MAP3K14(1), NCK2(3), NFAT5(3), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NRAS(39), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PDCD1(3), PDK1(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PRKCQ(12), PTPN6(1), PTPRC(18), RASGRP1(7), SOS1(6), SOS2(3), TEC(7), TNF(1), VAV1(13), VAV2(3), VAV3(6), ZAP70(4)	20295607	433	104	386	200	280	31	25	67	30	0	0.0993	1.000	1.000
148	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(1), APC(12), AR(7), BRAF(78), CAMP(1), CCL15(2), CCL16(1), DAG1(3), EGFR(16), GNA11(6), GNA15(2), GNAI1(1), GNAQ(1), ITPKB(5), ITPR1(19), ITPR2(10), ITPR3(4), KCNJ3(14), KCNJ5(6), KCNJ9(4), MAPK1(3), MAPK10(6), MAPK14(4), PHKA2(6), PIK3CA(2), PIK3CD(2), PIK3R1(2), PITX2(1), RAF1(2), SRC(1)	10626575	222	104	158	102	106	17	9	76	14	0	0.338	1.000	1.000
149	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AKR1C1(2), AKR1C2(2), AKR1C3(6), AKR1C4(4), ALDH1A3(2), ALDH3A1(4), ALDH3B1(2), ALDH3B2(5), CYP1A1(8), CYP1A2(8), CYP1B1(1), CYP2B6(11), CYP2C18(18), CYP2C19(29), CYP2C8(21), CYP2C9(28), CYP2E1(8), CYP2F1(8), CYP2S1(8), CYP3A4(13), CYP3A43(10), CYP3A5(4), CYP3A7(14), DHDH(4), EPHX1(1), GSTA1(5), GSTA2(1), GSTA3(1), GSTA5(2), GSTK1(1), GSTM1(1), GSTM2(2), GSTM3(2), GSTM4(1), GSTM5(3), GSTT1(1), MGST1(1), MGST2(1), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2A1(12), UGT2A3(17), UGT2B10(20), UGT2B11(11), UGT2B15(18), UGT2B28(15), UGT2B4(23), UGT2B7(13)	11436752	500	103	476	217	373	33	22	34	38	0	3.56e-06	1.000	1.000
150	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(12), CD14(4), CD19(5), CD1A(6), CD1B(6), CD1C(13), CD1D(6), CD1E(13), CD2(20), CD22(16), CD33(12), CD34(2), CD36(3), CD37(1), CD38(3), CD3D(5), CD3E(2), CD4(4), CD44(5), CD5(3), CD55(2), CD59(1), CD8A(2), CD8B(6), CR1(35), CR2(20), CSF1(8), CSF1R(9), CSF2(2), CSF2RA(11), CSF3(2), CSF3R(6), DNTT(7), EPO(4), EPOR(1), FCER2(2), FCGR1A(3), FLT3(21), FLT3LG(1), GP5(2), GP9(5), GYPA(4), HLA-DRA(7), HLA-DRB1(2), IL11(2), IL11RA(1), IL1A(3), IL1B(5), IL1R1(7), IL1R2(5), IL2RA(4), IL3(2), IL3RA(4), IL4(1), IL4R(7), IL5(4), IL5RA(7), IL6R(2), IL7(3), IL7R(15), IL9R(4), ITGA1(15), ITGA2(7), ITGA2B(7), ITGA3(4), ITGA4(26), ITGA5(13), ITGA6(6), ITGAM(19), ITGB3(9), KIT(7), KITLG(6), MME(12), MS4A1(4), TFRC(3), THPO(4), TNF(1), TPO(30)	16261398	553	103	528	279	419	27	15	35	57	0	0.0458	1.000	1.000
151	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(3), ARHGAP5(9), BCAR1(3), CD99(1), CDH5(6), CLDN1(5), CLDN10(3), CLDN11(3), CLDN14(5), CLDN16(4), CLDN17(3), CLDN18(6), CLDN19(2), CLDN2(4), CLDN20(1), CLDN22(1), CLDN4(7), CLDN6(6), CLDN7(1), CLDN8(2), CLDN9(1), CTNNA1(2), CTNNA2(17), CTNNA3(19), CTNNB1(6), CTNND1(7), CXCL12(1), CXCR4(1), CYBA(1), CYBB(5), ESAM(3), EZR(1), F11R(4), GNAI1(1), GNAI2(3), GRLF1(3), ICAM1(2), ITGA4(26), ITGAL(17), ITGAM(19), ITGB1(4), ITGB2(10), ITK(19), JAM2(9), JAM3(1), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MLLT4(9), MMP2(3), MMP9(5), MYL2(4), MYL5(1), MYL9(1), MYLPF(1), NCF2(5), NCF4(3), NOX1(7), NOX3(5), OCLN(2), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PLCG1(4), PLCG2(15), PRKCA(8), PRKCG(10), PTK2(3), PTK2B(7), PTPN11(5), PXN(3), RAC1(9), RAP1A(1), RAPGEF3(4), RAPGEF4(8), RASSF5(3), RHOH(4), ROCK1(3), ROCK2(4), SIPA1(5), TXK(6), VASP(1), VAV1(13), VAV2(3), VAV3(6), VCAM1(13), VCL(4)	24704313	521	103	504	267	376	33	11	57	42	2	0.0176	1.000	1.000
152	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), AKT2(6), AKT3(3), CASP9(3), CHP(1), HRAS(1), KDR(25), KRAS(1), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK3(1), MAPKAPK2(2), MAPKAPK3(1), NFAT5(3), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NOS3(13), NRAS(39), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PLCG1(4), PLCG2(15), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PRKCA(8), PRKCG(10), PTGS2(6), PTK2(3), PXN(3), RAC1(9), RAF1(2), SH2D2A(2), SHC2(4), SPHK1(1), SPHK2(5), SRC(1), VEGFA(1)	14420890	326	102	281	131	213	16	19	58	20	0	0.00185	1.000	1.000
153	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), AKT2(6), AKT3(3), BTK(8), CSF2(2), FCER1A(8), FCER1G(1), FYN(5), GAB2(1), GRB2(2), HRAS(1), IL13(2), IL3(2), IL4(1), IL5(4), INPP5D(22), KRAS(1), LCP2(5), LYN(3), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAPK1(3), MAPK10(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK3(1), MAPK9(1), MS4A2(5), NRAS(39), PDK1(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PLCG1(4), PLCG2(15), PRKCA(8), PRKCD(2), PRKCE(4), RAC1(9), RAF1(2), SOS1(6), SOS2(3), SYK(11), TNF(1), VAV1(13), VAV2(3), VAV3(6)	14445693	339	101	295	125	215	21	24	56	23	0	0.000134	1.000	1.000
154	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(3), BCAR1(3), CAPN1(1), CAPN10(6), CAPN11(7), CAPN2(2), CAPN3(6), CAPN5(4), CAPN6(9), CAPN7(1), CAPN9(7), CAPNS1(1), CAV1(1), CRK(2), CSK(1), DOCK1(13), FYN(5), GIT2(3), GRB2(2), ITGA10(4), ITGA11(13), ITGA2(7), ITGA2B(7), ITGA3(4), ITGA4(26), ITGA5(13), ITGA6(6), ITGA7(15), ITGA8(26), ITGA9(9), ITGAD(17), ITGAE(8), ITGAL(17), ITGAM(19), ITGAV(5), ITGAX(14), ITGB1(4), ITGB2(10), ITGB3(9), ITGB4(12), ITGB5(1), ITGB6(8), ITGB7(4), ITGB8(10), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K6(2), MAPK10(6), MAPK12(1), MAPK4(10), MAPK6(3), MAPK7(2), MYLK2(6), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PDPK1(3), PIK3R2(2), PTK2(3), PXN(3), RAC1(9), RAPGEF1(4), RHO(2), ROCK1(3), ROCK2(4), SDCCAG8(2), SEPP1(1), SHC1(1), SHC3(9), SORBS1(8), SOS1(6), SRC(1), TLN1(10), TNS1(5), VASP(1), VAV2(3), VAV3(6), VCL(4), ZYX(4)	26552765	498	99	485	234	363	31	19	51	33	1	0.00289	1.000	1.000
155	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(3), ATM(10), BUB1(1), BUB1B(7), CCNA1(12), CCNB2(1), CCNB3(17), CCND2(4), CCND3(1), CCNE1(3), CCNE2(10), CCNH(1), CDAN1(4), CDC14A(2), CDC14B(1), CDC25A(6), CDC25B(3), CDC25C(3), CDC6(1), CDC7(2), CDH1(4), CDK4(2), CDKN1A(2), CDKN2A(23), CHEK1(1), DTX4(2), E2F1(5), E2F2(3), E2F3(2), EP300(8), ESPL1(11), GSK3B(2), HDAC1(1), HDAC3(3), HDAC4(8), HDAC5(3), HDAC6(2), HDAC8(2), MAD1L1(4), MAD2L2(1), MCM2(8), MCM3(7), MCM4(3), MCM5(2), MCM6(3), MDM2(2), MPEG1(5), MPL(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(2), ORC5L(1), ORC6L(2), PCNA(1), PRKDC(13), PTPRA(3), PTTG1(1), PTTG2(5), RB1(3), RBL1(5), TBC1D8(5), TFDP1(1), TP53(26), WEE1(2)	22013395	287	98	269	102	169	24	14	33	45	2	0.000468	1.000	1.000
156	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(1), AKT2(6), AKT3(3), BCL10(1), BLNK(11), BTK(8), CARD11(22), CD19(5), CD22(16), CD72(4), CD79A(1), CD81(2), CHP(1), CHUK(1), CR2(20), FCGR2B(1), FOS(1), GSK3B(2), HRAS(1), IKBKB(2), INPP5D(22), JUN(1), KRAS(1), LILRB3(4), LYN(3), MALT1(3), NFAT5(3), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NRAS(39), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PLCG2(15), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PTPN6(1), RAC1(9), RASGRP3(8), SYK(11), VAV1(13), VAV2(3), VAV3(6)	14925180	347	98	306	133	219	19	26	55	28	0	0.000505	1.000	1.000
157	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(14), AMY2A(4), AMY2B(7), ENPP1(9), ENPP3(10), G6PC(4), GAA(5), GANAB(5), GBA3(6), GBE1(7), GCK(10), GPI(2), GUSB(3), GYS1(2), GYS2(10), HK1(1), HK2(5), HK3(10), MGAM(89), PGM1(2), PGM3(1), PYGB(2), PYGL(4), PYGM(7), SI(44), UCHL1(4), UCHL3(2), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2B15(18), UGT2B4(23), UXS1(1)	11337037	361	97	342	157	261	33	12	25	30	0	0.00292	1.000	1.000
158	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(21), ASH2L(3), CARM1(4), CTCFL(13), DOT1L(5), EED(3), EHMT1(6), EHMT2(4), EZH1(3), EZH2(6), FBXO11(2), HCFC1(12), JMJD4(3), JMJD6(1), MEN1(2), MLL(23), MLL2(36), MLL3(36), MLL4(23), MLL5(7), NSD1(10), OGT(5), PAXIP1(2), PPP1CA(1), PPP1CB(3), PPP1CC(1), PRDM2(11), PRDM7(2), PRDM9(32), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), RBBP5(4), SATB1(10), SETD1A(17), SETD2(10), SETD7(1), SETDB1(1), SETDB2(3), SETMAR(3), STK38(2), SUV39H1(1), SUV420H1(5), SUV420H2(1), SUZ12(2), WHSC1(5), WHSC1L1(5)	23660186	364	96	360	129	242	46	11	37	28	0	0.00575	1.000	1.000
159	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(10), CCNA1(12), CCND1(1), CCND2(4), CCND3(1), CCNE1(3), CCNE2(10), CCNH(1), CDC25A(6), CDK4(2), CDKN1A(2), CDKN1B(1), CDKN2A(23), CDKN2C(1), CREB3L1(3), CREB3L3(6), CREB3L4(2), E2F1(5), E2F2(3), E2F3(2), GBA2(2), MCM2(8), MCM3(7), MCM4(3), MCM5(2), MCM6(3), MDM2(2), MNAT1(2), MYC(2), MYT1(15), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(2), ORC5L(1), ORC6L(2), PCNA(1), POLA2(6), POLE(10), POLE2(1), PRIM1(1), RB1(3), RBL1(5), RPA1(3), RPA2(1), TFDP1(1), TFDP2(3), TNXB(78), TP53(26), WEE1(2)	15890425	294	96	277	112	180	16	9	38	49	2	0.00206	1.000	1.000
160	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(3), ALG1(2), ALG10B(3), ALG12(1), ALG13(4), ALG2(3), ALG3(1), ALG6(2), ALG8(3), ALG9(5), B3GNT1(2), B3GNT2(2), B3GNT7(3), B4GALT1(1), B4GALT2(2), B4GALT3(2), B4GALT5(2), C1GALT1(5), C1GALT1C1(1), CHPF(3), CHST1(7), CHST11(4), CHST12(1), CHST13(2), CHST14(2), CHST2(2), CHST4(8), CHST6(4), CHSY1(5), DDOST(2), DPAGT1(2), EXT1(1), EXT2(3), EXTL1(1), EXTL3(5), FUT11(2), FUT8(5), GALNT1(2), GALNT10(4), GALNT11(1), GALNT12(5), GALNT13(12), GALNT14(16), GALNT2(4), GALNT3(2), GALNT4(2), GALNT5(9), GALNT6(13), GALNT7(5), GALNT8(14), GALNT9(3), GALNTL1(2), GALNTL2(13), GALNTL4(1), GALNTL5(13), GANAB(5), GCNT1(4), GCNT3(3), HS2ST1(1), HS3ST1(8), HS3ST2(6), HS3ST3B1(2), HS3ST5(5), HS6ST1(3), HS6ST2(1), HS6ST3(9), MAN1A1(8), MAN1A2(3), MAN1B1(2), MAN1C1(6), MAN2A1(8), MGAT1(1), MGAT3(9), MGAT4A(5), MGAT5(2), MGAT5B(8), NDST1(3), NDST3(14), NDST4(32), OGT(5), RPN2(2), ST3GAL1(5), ST3GAL4(1), ST6GAL1(4), ST6GALNAC1(3), STT3B(3), WBSCR17(24), XYLT1(8), XYLT2(2)	21863327	432	96	422	227	292	37	13	43	47	0	0.0720	1.000	1.000
161	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(5), ABCA10(13), ABCA12(39), ABCA13(39), ABCA2(7), ABCA3(12), ABCA4(37), ABCA5(4), ABCA6(21), ABCA7(6), ABCA8(24), ABCA9(14), ABCB1(26), ABCB10(2), ABCB11(35), ABCB4(9), ABCB5(26), ABCB6(1), ABCB7(4), ABCB8(2), ABCB9(6), ABCC1(8), ABCC10(10), ABCC11(12), ABCC12(16), ABCC2(7), ABCC3(20), ABCC4(9), ABCC5(5), ABCC6(17), ABCC8(24), ABCC9(40), ABCD2(9), ABCD3(7), ABCD4(1), ABCG1(7), ABCG2(6), ABCG4(5), ABCG5(5), ABCG8(11), CFTR(29), TAP1(1), TAP2(11)	23584184	592	96	571	349	420	44	15	53	60	0	0.0451	1.000	1.000
162	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AKT1(1), AKT2(6), AKT3(3), APAF1(3), ATM(10), BAX(1), BCL2(2), BIRC2(4), BIRC3(6), CAPN1(1), CAPN2(2), CASP10(4), CASP3(1), CASP7(4), CASP8(2), CASP9(3), CFLAR(3), CHP(1), CHUK(1), CSF2RB(14), CYCS(1), DFFA(1), DFFB(2), FAS(3), FASLG(10), IKBKB(2), IL1A(3), IL1B(5), IL1R1(7), IL1RAP(3), IL3(2), IL3RA(4), IRAK2(10), IRAK3(7), IRAK4(2), MAP3K14(1), MYD88(2), NFKB1(3), NFKB2(3), NFKBIA(2), NTRK1(10), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), PPP3CA(4), PPP3CB(1), PPP3CC(1), PPP3R2(6), PRKACA(2), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RELA(2), RIPK1(1), TNF(1), TNFRSF10A(4), TNFRSF10B(1), TNFRSF10C(4), TNFRSF10D(6), TNFRSF1A(2), TNFSF10(5), TP53(26), TRAF2(2)	16652721	285	96	279	146	187	17	15	34	32	0	0.319	1.000	1.000
163	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(1), ACVR1B(3), ACVRL1(4), AKT1(1), AURKB(2), BMPR1A(1), BMPR2(4), BUB1(1), CDKL1(4), CDKL2(2), CDS1(6), CDS2(4), CLK1(3), CLK2(4), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), DGKA(1), DGKB(16), DGKD(5), DGKE(5), DGKG(10), DGKH(6), DGKQ(3), DGKZ(6), IMPA1(1), INPP1(2), INPP4A(4), INPP5A(3), INPPL1(11), ITPKB(5), MAP3K10(5), MOS(5), NEK1(7), NEK3(1), OCRL(3), PAK4(4), PIK3C2A(4), PIK3C2B(9), PIK3C2G(32), PIK3CA(2), PIK3CB(10), PIK3CG(18), PIM2(1), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PLCD1(2), PLCG1(4), PLCG2(15), PRKACA(2), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), PRKCD(2), PRKCE(4), PRKCG(10), PRKCH(5), PRKCQ(12), PRKCZ(1), PRKD1(2), PRKG1(7), RAF1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA4(2), RPS6KB1(2), STK11(2)	22448583	414	96	397	227	304	24	13	31	42	0	0.398	1.000	1.000
164	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(17), ADCY2(6), ADCY3(2), ADCY4(2), ADCY5(9), ADCY6(6), ADCY7(8), ADCY8(30), ADK(3), ADSL(6), ADSS(1), AK1(1), AK2(1), AK5(6), ALLC(5), AMPD1(22), AMPD2(4), AMPD3(16), APRT(1), ATIC(2), ATP1B1(1), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(6), ATP5H(1), CANT1(8), DGUOK(4), ENPP1(9), ENPP3(10), ENTPD1(5), ENTPD2(4), FHIT(2), GART(7), GDA(6), GMPS(3), GUCY1A2(11), GUCY1A3(20), GUCY1B3(4), GUCY2C(20), GUCY2D(3), GUCY2F(10), GUK1(1), IMPDH2(1), NPR1(13), NPR2(12), NT5E(4), NT5M(1), PAPSS1(2), PAPSS2(4), PDE1A(22), PDE4A(3), PDE4B(6), PDE4C(11), PDE4D(5), PDE5A(5), PDE6B(11), PDE6C(18), PDE6G(2), PDE7B(12), PDE8A(2), PDE9A(6), PFAS(5), PKLR(6), PKM2(5), POLD1(3), POLD2(2), POLE(10), POLG(4), POLL(7), POLQ(15), POLR1B(5), POLR2A(10), POLR2B(11), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(1), PRPS1(1), PRPS1L1(8), PRPS2(1), PRUNE(1), RRM1(3)	25580381	533	96	510	271	376	38	14	51	54	0	0.00889	1.000	1.000
165	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(1), AKT2(6), AKT3(3), CASP8(2), CD14(4), CD40(1), CD80(3), CD86(16), CHUK(1), CXCL10(2), CXCL11(1), CXCL9(2), FOS(1), IFNA10(2), IFNA14(6), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(3), IFNAR1(1), IFNAR2(5), IFNB1(5), IKBKB(2), IKBKE(7), IL12A(2), IL12B(3), IL1B(5), IL8(1), IRAK4(2), IRF3(3), IRF5(2), IRF7(5), JUN(1), LBP(6), LY96(3), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAPK1(3), MAPK10(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK3(1), MAPK9(1), MYD88(2), NFKB1(3), NFKB2(3), NFKBIA(2), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(8), RAC1(9), RELA(2), RIPK1(1), SPP1(4), STAT1(2), TBK1(2), TICAM1(6), TLR1(7), TLR2(10), TLR3(7), TLR4(26), TLR5(14), TLR6(3), TLR7(6), TLR8(5), TLR9(8), TNF(1), TOLLIP(1), TRAF3(3), TRAF6(2)	17927940	342	95	330	167	234	25	14	44	25	0	0.0350	1.000	1.000
166	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(3), BRAF(78), CREB5(7), DUSP4(1), DUSP6(1), DUSP9(1), EEF2K(2), GRB2(2), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), MKNK1(5), MKNK2(2), MOS(5), NFKB1(3), RAP1A(1), RPS6KA1(4), RPS6KA2(4), SHC1(1), SOS1(6), SOS2(3), TRAF3(3)	5895406	145	95	80	47	61	7	4	69	4	0	0.139	1.000	1.000
167	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(1), IMPA2(2), INPP1(2), INPP4A(4), INPP5A(3), INPP5B(4), INPPL1(11), IPMK(2), ISYNA1(1), ITPK1(5), ITPKB(5), MIOX(3), OCRL(3), PI4KA(9), PI4KB(3), PIK3C3(1), PIK3CA(2), PIK3CB(10), PIK3CD(2), PIK3CG(18), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(6), PIP5K1B(15), PIP5K1C(4), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PLCD1(2), PLCD3(2), PLCD4(1), PLCE1(27), PLCG1(4), PLCG2(15), PLCZ1(13), PTEN(12), SYNJ1(11), SYNJ2(11)	14754171	305	94	295	148	217	17	15	28	28	0	0.0404	1.000	1.000
168	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AGK(4), AGPAT2(3), AGPAT3(3), AGPAT4(5), AGPAT6(2), AKR1A1(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), CEL(6), DAK(2), DGAT2(2), DGKA(1), DGKB(16), DGKD(5), DGKE(5), DGKG(10), DGKH(6), DGKI(14), DGKQ(3), DGKZ(6), GK(5), GK2(21), GLA(1), GLB1(5), GPAM(5), LCT(31), LIPA(1), LIPC(6), LIPF(12), LIPG(5), LPL(2), MGLL(3), PNLIP(5), PNLIPRP1(9), PNLIPRP2(2), PNPLA3(1), PPAP2B(4), PPAP2C(6)	11791742	315	93	296	137	222	27	13	29	24	0	0.00129	1.000	1.000
169	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(4), AKR1D1(14), ARSD(2), ARSE(4), CARM1(4), CYP11B1(8), CYP11B2(9), CYP19A1(8), HEMK1(1), HSD11B1(8), HSD17B12(1), HSD17B2(7), HSD17B3(5), HSD3B1(4), HSD3B2(9), LCMT1(4), METTL2B(6), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), SRD5A1(2), SRD5A2(5), STS(3), SULT1E1(10), SULT2A1(4), SULT2B1(6), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2A1(12), UGT2A3(17), UGT2B10(20), UGT2B11(11), UGT2B15(18), UGT2B28(15), UGT2B4(23), UGT2B7(13), WBSCR22(1)	9971427	328	92	315	133	224	31	15	23	35	0	9.08e-05	1.000	1.000
170	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(3), ACADL(2), ACADM(5), ACOX1(3), ACOX2(7), ACOX3(5), ACSL1(3), ACSL3(3), ACSL5(13), ACSL6(6), ADIPOQ(3), ANGPTL4(4), APOA1(2), APOA5(4), AQP7(3), CD36(3), CPT1A(7), CPT1B(6), CPT1C(12), CPT2(1), CYP27A1(2), CYP4A11(14), CYP4A22(17), CYP7A1(5), CYP8B1(6), EHHADH(5), FABP1(3), FABP2(5), FABP3(1), FABP4(1), FADS2(2), GK(5), GK2(21), HMGCS2(14), LPL(2), ME1(14), MMP1(6), NR1H3(2), OLR1(3), PCK1(20), PCK2(3), PDPK1(3), PPARA(4), PPARD(2), PPARG(8), RXRA(1), RXRB(1), RXRG(3), SCD(2), SLC27A1(3), SLC27A2(7), SLC27A4(4), SLC27A5(4), SLC27A6(19), SORBS1(8), UBC(4), UCP1(4)	13165611	323	92	311	179	243	27	12	18	22	1	0.149	1.000	1.000
171	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(3), ACTB(4), ACTG1(4), ACTN1(2), ACTN2(14), ACTN3(5), ACTN4(3), ACVR1B(3), ACVR1C(7), BAIAP2(3), CDH1(4), CREBBP(14), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(17), CTNNA3(19), CTNNB1(6), CTNND1(7), EGFR(16), EP300(8), ERBB2(3), FARP2(2), FER(1), FGFR1(7), FYN(5), IGF1R(6), INSR(13), IQGAP1(7), LEF1(1), LMO7(20), MAPK1(3), MAPK3(1), MET(12), MLLT4(9), NLK(4), PARD3(10), PTPN1(2), PTPN6(1), PTPRB(59), PTPRF(19), PTPRJ(5), PTPRM(5), PVRL1(3), PVRL2(2), PVRL3(2), PVRL4(6), RAC1(9), SMAD2(1), SNAI1(1), SNAI2(1), SORBS1(8), SRC(1), SSX2IP(3), TCF7(1), TCF7L1(1), TCF7L2(4), TGFBR2(5), TJP1(9), VCL(4), WAS(5), WASF1(1), WASF2(4), WASF3(11), WASL(3), YES1(3)	24080836	427	92	408	223	308	26	9	37	44	3	0.379	1.000	1.000
172	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(7), AGTR2(3), ATP8A1(13), AVPR1A(3), AVPR1B(5), BDKRB1(5), BDKRB2(2), BRS3(2), C3AR1(3), CCKAR(9), CCKBR(8), CCR1(5), CCR10(2), CCR2(8), CCR3(8), CCR4(5), CCR5(5), CCR6(1), CCR7(3), CCR8(2), CX3CR1(10), CXCR3(2), CXCR4(1), CXCR6(4), EDNRA(4), EDNRB(4), FPR1(15), FSHR(12), GALR1(3), GALT(2), GHSR(6), GNB2L1(2), GNRHR(2), GPR77(3), GRPR(3), LHCGR(14), MC2R(3), MC3R(6), MC4R(1), MC5R(5), NMBR(3), NPY1R(12), NPY2R(8), NPY5R(12), NTSR1(4), NTSR2(2), OPRK1(15), OPRL1(5), OPRM1(4), OXTR(3), PPYR1(10), SSTR1(7), SSTR2(2), SSTR3(10), SSTR4(1), TACR1(5), TACR2(3), TACR3(17), TRHR(13), TSHR(7)	10487135	344	92	334	258	245	27	13	32	27	0	0.0745	1.000	1.000
173	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(1), ACVR1B(3), ACVR1C(7), ACVR2A(3), ACVR2B(1), ACVRL1(4), AMHR2(9), BMP2(4), BMP4(2), BMP5(12), BMP6(8), BMP7(2), BMPR1A(1), BMPR1B(2), BMPR2(4), CHRD(8), COMP(5), CREBBP(14), CUL1(4), DCN(14), EP300(8), FST(3), GDF5(9), GDF6(1), GDF7(2), ID2(2), IFNG(2), INHBA(12), INHBB(4), INHBC(6), INHBE(2), LEFTY1(4), LEFTY2(1), LTBP1(28), MAPK1(3), MAPK3(1), MYC(2), NODAL(2), NOG(1), PITX2(1), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(3), PPP2R2C(4), RBL1(5), RBL2(2), ROCK1(3), ROCK2(4), RPS6KB1(2), RPS6KB2(2), SMAD1(4), SMAD2(1), SMAD5(3), SMAD6(5), SMAD9(8), SMURF1(1), SMURF2(5), SP1(4), TFDP1(1), TGFB2(1), TGFB3(1), TGFBR2(5), THBS1(19), THBS2(8), THBS3(7), THBS4(7), TNF(1), ZFYVE16(3), ZFYVE9(5)	19888619	325	91	320	180	217	33	15	27	33	0	0.753	1.000	1.000
174	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(3), ATM(10), ATR(13), BAI1(11), BAX(1), CASP3(1), CASP8(2), CASP9(3), CCNB2(1), CCNB3(17), CCND1(1), CCND2(4), CCND3(1), CCNE1(3), CCNE2(10), CCNG1(1), CDK4(2), CDK6(1), CDKN1A(2), CDKN2A(23), CHEK1(1), CYCS(1), DDB2(2), EI24(1), FAS(3), GADD45B(1), GTSE1(5), IGF1(7), IGFBP3(1), LRDD(3), MDM2(2), MDM4(1), PERP(1), PPM1D(2), PTEN(12), RFWD2(3), RRM2B(1), SERPINB5(8), SERPINE1(2), SESN2(3), SESN3(1), SFN(1), STEAP3(3), THBS1(19), TNFRSF10B(1), TP53(26), TP73(4), TSC2(7), ZMAT3(1)	12992063	233	90	215	100	128	10	16	31	48	0	0.109	1.000	1.000
175	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(33), COL4A2(20), COL4A3(24), COL4A4(58), COL4A5(41), COL4A6(28), F10(4), F11(9), F12(1), F2(6), F2R(4), F5(20), F8(29), F9(6), FGA(20), FGB(7), FGG(4), KLKB1(16), PROC(7), PROS1(9), SERPINC1(5), SERPING1(8)	8889442	359	89	349	116	286	21	14	22	16	0	0.176	1.000	1.000
176	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(10), ALG6(2), CCKBR(8), CCR2(8), CCR3(8), CCR5(5), CELSR1(21), CELSR2(19), CELSR3(20), CHRM2(10), CHRM3(11), CXCR3(2), DRD4(1), EDNRA(4), EMR2(1), EMR3(15), F2R(4), FSHR(12), GHRHR(4), GNRHR(2), GPR116(25), GPR132(3), GPR133(8), GPR143(2), GPR17(1), GPR18(1), GPR55(4), GPR56(3), GPR61(4), GPR77(3), GPR84(6), GRM1(9), GRPR(3), HRH4(4), LGR6(9), LPHN2(24), LPHN3(10), NTSR1(4), OR2M4(10), OR8G2(6), P2RY13(3), PTGFR(13), SMO(6), SSTR2(2), TAAR5(1), TSHR(7)	13314060	338	88	330	237	229	28	12	43	25	1	0.450	1.000	1.000
177	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(1), AKT2(6), AKT3(3), BCR(6), BTK(8), CD19(5), CDKN2A(23), DAPP1(4), FLOT1(1), GAB1(3), ITPR1(19), ITPR2(10), ITPR3(4), LYN(3), NR0B2(6), PDK1(1), PIK3CA(2), PITX2(1), PLCG2(15), PPP1R13B(5), PREX1(3), PTEN(12), PTPRC(18), RPS6KA1(4), RPS6KA2(4), RPS6KB1(2), SAG(5), SYK(11), TEC(7), VAV1(13)	11016881	205	87	188	109	128	14	11	14	38	0	0.209	1.000	1.000
178	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(11), ACAT2(1), ACMSD(7), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), AOC2(5), AOC3(6), AOX1(15), ASMT(4), CAT(4), CYP19A1(8), CYP1A1(8), CYP1A2(8), CYP2A13(6), CYP2A6(9), CYP2A7(6), CYP2B6(11), CYP2C18(18), CYP2C19(29), CYP2C8(21), CYP2C9(28), CYP2D6(1), CYP2E1(8), CYP2F1(8), CYP2J2(4), CYP3A4(13), CYP3A5(4), CYP3A7(14), CYP4B1(11), CYP4F8(7), CYP51A1(1), DDC(7), EHHADH(5), GCDH(3), HAAO(3), HADHA(7), KMO(5), KYNU(6), MAOA(2), MAOB(7), TDO2(2), TPH1(2), WARS(3), WARS2(1)	10978483	356	87	343	213	286	21	13	17	19	0	0.148	1.000	1.000
179	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(3), ACAA2(1), ACADL(2), ACADM(5), ACADS(2), ACADSB(3), ACADVL(1), ACAT2(1), ACOX1(3), ACOX3(5), ACSL1(3), ACSL3(3), ACSL5(13), ACSL6(6), ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), CPT1A(7), CPT1B(6), CPT1C(12), CPT2(1), CYP4A11(14), CYP4A22(17), DCI(2), EHHADH(5), GCDH(3), HADHA(7), HADHB(2), HSD17B10(1), HSD17B4(3), PECI(1)	9867300	227	86	216	102	170	17	11	15	13	1	0.0144	1.000	1.000
180	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CDC40(4), CLK2(4), COL2A1(18), CPSF1(5), CPSF2(1), CPSF3(2), CSTF1(5), CSTF2(3), CSTF2T(3), CSTF3(4), DDIT3(1), DDX20(7), DHX15(3), DHX16(6), DHX38(5), DHX8(5), DHX9(6), DICER1(13), DNAJC8(2), GIPC1(3), LOC440563(14), LSM7(1), METTL3(1), NCBP1(1), NONO(6), NUDT21(2), NXF1(2), PABPN1(1), PAPOLA(3), POLR2A(10), PRPF18(2), PRPF3(2), PRPF4(3), PRPF4B(3), PRPF8(10), PSKH1(2), PTBP1(1), PTBP2(5), RBM17(1), RBM5(5), RNGTT(1), RNMT(6), SF3A1(5), SF3A2(2), SF3A3(2), SF3B1(8), SF3B2(6), SF3B4(4), SF4(4), SFRS12(2), SFRS14(8), SFRS16(5), SFRS5(1), SFRS6(2), SFRS8(1), SFRS9(2), SNRPA(1), SNRPA1(1), SNRPB(4), SNRPB2(1), SNRPE(1), SNRPN(4), SNURF(2), SPOP(2), SRPK1(4), SRPK2(2), SRRM1(6), SUPT5H(4), TXNL4A(1), U2AF2(2), XRN2(4)	21354684	274	86	274	111	186	22	14	31	21	0	0.127	1.000	1.000
181	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(1), AKT2(6), AKT3(3), CDKN1B(1), CDKN2A(23), CREB5(7), ERBB4(30), F2RL2(4), GAB1(3), GRB2(2), GSK3B(2), IFI27(2), IGF1(7), IGFBP1(2), INPPL1(11), IRS1(3), IRS2(1), IRS4(7), MET(12), MYC(2), NOLC1(2), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PARD3(10), PDK1(1), PIK3CA(2), PIK3CD(2), PPP1R13B(5), PREX1(3), PTEN(12), PTK2(3), PTPN1(2), RPS6KA1(4), RPS6KA2(4), RPS6KB1(2), SFN(1), SHC1(1), SLC2A4(6), SOS1(6), SOS2(3), TSC1(3), TSC2(7), YWHAG(1), YWHAQ(2)	15478380	259	86	244	126	152	24	12	26	45	0	0.270	1.000	1.000
182	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(11), ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), ALDH1A3(2), ALDH3A1(4), ALDH3B1(2), ALDH3B2(5), AOC2(5), AOC3(6), AOX1(15), CARM1(4), COMT(2), DBH(5), DCT(2), DDC(7), ECH1(1), FAH(4), GOT1(4), GOT2(2), HEMK1(1), HGD(11), HPD(3), LCMT1(4), MAOA(2), MAOB(7), METTL2B(6), MYST3(10), MYST4(11), NAT6(2), PNMT(4), PNPLA3(1), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), SH3GLB1(2), TAT(12), TH(7), TPO(30), TYR(5), TYRP1(5), WBSCR22(1)	11901391	303	85	291	158	228	26	15	22	12	0	0.129	1.000	1.000
183	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(7), ADCY4(2), ADCY6(6), ADCY8(30), CACNA1A(22), CACNA1B(20), GNAS(12), GNAT3(3), GNB3(5), GRM4(15), ITPR3(4), KCNB1(18), PDE1A(22), PLCB2(7), PRKACA(2), PRKACB(2), PRKACG(7), PRKX(1), SCNN1A(5), SCNN1B(12), SCNN1G(18), TAS1R1(7), TAS1R2(13), TAS1R3(1), TAS2R1(5), TAS2R10(6), TAS2R13(2), TAS2R14(1), TAS2R16(5), TAS2R38(12), TAS2R39(7), TAS2R4(2), TAS2R40(3), TAS2R41(8), TAS2R46(1), TAS2R5(2), TAS2R60(13), TAS2R7(2), TAS2R8(3), TAS2R9(4), TRPM5(9)	11325411	326	85	311	272	231	21	10	34	30	0	0.875	1.000	1.000
184	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(4), BCL2(2), CABIN1(3), CALM2(1), CAMK2B(2), CAMK4(9), CD3E(2), CD69(4), CDKN1A(2), CNR1(7), CREBBP(14), CSF2(2), CSNK2A1(1), CSNK2B(1), CTLA4(1), EGR2(4), EGR3(1), EP300(8), FCER1A(8), FCGR3A(5), FOS(1), GATA3(8), GATA4(2), GRLF1(3), GSK3B(2), HRAS(1), ICOS(2), IFNB1(5), IFNG(2), IL10(2), IL13(2), IL1B(5), IL2(4), IL2RA(4), IL3(2), IL4(1), IL8(1), ITK(19), KPNA5(1), MAP2K7(2), MAPK14(4), MAPK9(1), MEF2A(2), MEF2B(2), MEF2D(2), MYF5(8), NCK2(3), NFAT5(3), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NFKB2(3), NFKBIB(1), NPPB(4), NUP214(10), P2RX7(3), PAK1(2), PIN1(1), PPIA(1), PPP3CB(1), PPP3CC(1), PTPRC(18), RELA(2), RPL13A(1), SFN(1), SLA(1), SP1(4), SP3(1), TNF(1), TRAF2(2), TRPV6(22), VAV1(13), VAV2(3), VAV3(6), XPO5(6)	18241661	313	84	303	155	232	24	12	20	25	0	0.0978	1.000	1.000
185	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(9), CAD(12), CANT1(8), CDA(2), CTPS(2), CTPS2(2), DCTD(1), DHODH(1), DPYD(38), DPYS(15), ENTPD1(5), ENTPD3(3), ENTPD4(3), ENTPD5(1), ENTPD6(3), ENTPD8(1), NME6(1), NME7(4), NT5C1A(1), NT5C1B(16), NT5C2(1), NT5C3(2), NT5E(4), NT5M(1), PNPT1(1), POLA1(1), POLA2(6), POLD1(3), POLD2(2), POLD3(3), POLE(10), POLE2(1), POLR1A(7), POLR1B(5), POLR1C(1), POLR2A(10), POLR2B(11), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(2), POLR3B(12), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(8), RRM1(3), RRM2B(1), TK2(1), TXNRD1(3), TXNRD2(2), TYMS(1), UCK1(2), UMPS(1), UPB1(5), UPP2(5)	16242748	253	83	243	121	163	24	13	32	21	0	0.101	1.000	1.000
186	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(14), ACSL1(3), ACSL3(3), ACSL5(13), ACSL6(6), ADIPOQ(3), ADIPOR1(3), ADIPOR2(1), AKT1(1), AKT2(6), AKT3(3), CAMKK1(1), CAMKK2(4), CD36(3), CHUK(1), CPT1A(7), CPT1B(6), CPT1C(12), CPT2(1), G6PC(4), G6PC2(2), IKBKB(2), IRS1(3), IRS2(1), IRS4(7), JAK1(4), JAK2(6), JAK3(5), LEP(1), LEPR(13), MAPK10(6), MAPK9(1), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NPY(2), PCK1(20), PCK2(3), POMC(3), PPARA(4), PPARGC1A(15), PRKAA1(1), PRKAA2(18), PRKAB2(1), PRKAG1(2), PRKAG2(3), PRKAG3(7), PRKCQ(12), PTPN11(5), RELA(2), RXRA(1), RXRB(1), RXRG(3), SLC2A1(3), SLC2A4(6), SOCS3(2), STAT3(6), STK11(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2), TYK2(4)	16630103	287	83	282	176	197	32	15	18	25	0	0.656	1.000	1.000
187	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(3), BAX(1), BTK(8), CAD(12), CASP10(4), CASP3(1), CASP8(2), CASP8AP2(3), CDK2AP1(2), CSNK1A1(2), DAXX(5), DEDD(1), DEDD2(3), DFFA(1), DIABLO(1), EGFR(16), EPHB2(17), FAF1(3), FAIM2(5), HSPB1(2), IL1A(3), IL8(1), MAP2K4(3), MAP2K7(2), MAP3K5(11), MAPK1(3), MAPK10(6), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(6), MAPK9(1), MET(12), NFAT5(3), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NR0B2(6), PTPN13(8), RALBP1(2), RIPK1(1), ROCK1(3), SMPD1(1), TNFRSF6B(2), TP53(26), TPX2(8), TRAF2(2), TUFM(2)	14548230	223	83	218	125	148	12	13	27	23	0	0.651	1.000	1.000
188	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(3), AGT(3), AKT1(1), CALM2(1), CAMK1(4), CAMK1G(9), CAMK4(9), CREBBP(14), CSNK1A1(2), EDN1(7), ELSPBP1(1), F2(6), FGF2(1), FKBP1A(2), GATA4(2), GSK3B(2), HAND2(4), HRAS(1), IGF1(7), LIF(1), MAP2K1(7), MAPK1(3), MAPK14(4), MAPK3(1), MEF2C(2), MYH2(53), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NPPA(1), PIK3CA(2), PIK3R1(2), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RAF1(2), RPS6KB1(2), SYT1(12)	10182603	224	82	216	129	172	17	9	14	12	0	0.571	1.000	1.000
189	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AGPAT2(3), AGPAT3(3), AGPAT4(5), AKR1A1(1), AKR1B1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), CEL(6), DGKA(1), DGKB(16), DGKD(5), DGKE(5), DGKG(10), DGKH(6), DGKQ(3), DGKZ(6), GK(5), GLA(1), GLB1(5), LCT(31), LIPC(6), LIPF(12), LIPG(5), LPL(2), PNLIP(5), PNLIPRP1(9), PNLIPRP2(2), PPAP2B(4), PPAP2C(6)	9670439	269	81	254	121	195	25	10	21	18	0	0.00395	1.000	1.000
190	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), APH1A(1), CREBBP(14), CTBP2(1), DLL1(2), DLL3(5), DLL4(5), DTX1(6), DTX2(3), DTX3(2), DTX3L(5), DTX4(2), DVL2(3), DVL3(5), EP300(8), HDAC1(1), HES1(1), JAG1(5), JAG2(4), LFNG(3), MAML1(2), MAML2(2), MAML3(6), MFNG(5), NCOR2(15), NCSTN(3), NOTCH1(4), NOTCH2(25), NOTCH3(16), NOTCH4(38), NUMB(2), NUMBL(3), PSEN1(1), PSEN2(2), PTCRA(1), RBPJ(2), RBPJL(1), SNW1(2)	13746540	207	81	207	120	120	23	8	39	17	0	0.919	1.000	1.000
191	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(3), AKT1(1), BDKRB2(2), CALM2(1), CAV1(1), CHRM1(4), CHRNA1(3), FLT1(21), FLT4(19), KDR(25), NOS3(13), PDE2A(11), PDE3A(14), PDE3B(5), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKG1(7), PRKG2(10), RYR2(54), SLC7A1(2), SYT1(12), TNNI1(1)	8146883	226	80	215	139	168	16	7	16	18	1	0.483	1.000	1.000
192	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(5), AGT(3), AGTR1(7), AGTR2(3), CMA1(4), COL4A1(33), COL4A2(20), COL4A3(24), COL4A4(58), COL4A5(41), COL4A6(28), REN(8)	5047818	234	79	227	76	198	11	5	9	11	0	0.766	1.000	1.000
193	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS2(3), ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AKR1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(5), ALDH7A1(3), ALDH9A1(2), ALDOA(1), ALDOB(8), ALDOC(1), BPGM(1), DLAT(2), DLD(1), ENO1(2), ENO3(2), FBP1(1), FBP2(1), G6PC(4), G6PC2(2), GALM(2), GCK(10), GPI(2), HK1(1), HK2(5), HK3(10), LDHA(2), LDHAL6A(1), LDHAL6B(6), LDHC(3), PDHA1(1), PDHA2(9), PDHB(1), PFKL(2), PGK1(2), PGK2(17), PGM1(2), PGM3(1), PKLR(6), PKM2(5)	11669876	220	79	208	105	163	14	11	15	17	0	0.00449	1.000	1.000
194	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(3), ACTB(4), ACTG1(4), ARHGEF2(9), CD14(4), CDH1(4), CLDN1(5), CTNNB1(6), CTTN(1), EZR(1), FYN(5), HCLS1(7), ITGB1(4), KRT18(2), LY96(3), NCK2(3), NCL(4), OCLN(2), PRKCA(8), ROCK1(3), ROCK2(4), TLR4(26), TLR5(14), TUBA1A(1), TUBA1B(3), TUBA1C(2), TUBA3C(12), TUBA3D(9), TUBA3E(1), TUBA4A(4), TUBA8(1), TUBAL3(8), TUBB1(2), TUBB2A(2), TUBB3(3), TUBB4(1), TUBB4Q(5), TUBB6(6), TUBB8(7), WAS(5), WASL(3), YWHAQ(2)	10509837	203	79	193	88	144	18	6	20	15	0	0.00958	1.000	1.000
195	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(3), ACTB(4), ACTG1(4), ARHGEF2(9), CD14(4), CDH1(4), CLDN1(5), CTNNB1(6), CTTN(1), EZR(1), FYN(5), HCLS1(7), ITGB1(4), KRT18(2), LY96(3), NCK2(3), NCL(4), OCLN(2), PRKCA(8), ROCK1(3), ROCK2(4), TLR4(26), TLR5(14), TUBA1A(1), TUBA1B(3), TUBA1C(2), TUBA3C(12), TUBA3D(9), TUBA3E(1), TUBA4A(4), TUBA8(1), TUBAL3(8), TUBB1(2), TUBB2A(2), TUBB3(3), TUBB4(1), TUBB4Q(5), TUBB6(6), TUBB8(7), WAS(5), WASL(3), YWHAQ(2)	10509837	203	79	193	88	144	18	6	20	15	0	0.00958	1.000	1.000
196	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(3), ACP2(2), ACP5(3), ACPP(6), ALPI(3), ALPL(6), ALPP(6), ALPPL2(7), CYP19A1(8), CYP1A1(8), CYP1A2(8), CYP2A13(6), CYP2A6(9), CYP2A7(6), CYP2B6(11), CYP2C18(18), CYP2C19(29), CYP2C8(21), CYP2C9(28), CYP2D6(1), CYP2E1(8), CYP2F1(8), CYP2J2(4), CYP3A4(13), CYP3A5(4), CYP3A7(14), CYP4B1(11), CYP4F8(7), CYP51A1(1), PON1(12)	5819064	271	78	257	159	221	13	9	9	19	0	0.0208	1.000	1.000
197	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(2), INPP4A(4), INPP5A(3), INPPL1(11), ITPKB(5), MIOX(3), OCRL(3), PIK3C2A(4), PIK3C2B(9), PIK3C2G(32), PIK3CA(2), PIK3CB(10), PIK3CG(18), PLCB1(33), PLCB2(7), PLCB3(2), PLCB4(42), PLCD1(2), PLCG1(4), PLCG2(15)	8930739	212	78	201	98	155	10	8	16	23	0	0.0383	1.000	1.000
198	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), AKT1(1), AKT2(6), AKT3(3), ANGPTL2(2), ARHGAP1(1), ARHGAP4(1), ARHGEF11(10), BTK(8), CFL1(1), GDI2(1), INPPL1(11), ITPR1(19), ITPR2(10), ITPR3(4), LIMK1(4), MYLK(22), MYLK2(6), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3CG(18), PIK3R1(2), PITX2(1), PPP1R13B(5), PTEN(12), RACGAP1(1), RHO(2), ROCK1(3), ROCK2(4), SAG(5), WASF1(1), WASL(3)	13989472	222	78	217	105	150	21	10	22	19	0	0.0598	1.000	1.000
199	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(1), AKT2(6), AKT3(3), BRD4(16), CBL(6), CDKN2A(23), F2RL2(4), FLOT1(1), GRB2(2), GSK3B(2), IGFBP1(2), INPPL1(11), IRS1(3), IRS2(1), IRS4(7), LNPEP(9), MAPK1(3), MAPK3(1), PARD3(10), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3R1(2), PPYR1(10), PTEN(12), PTPN1(2), RAF1(2), RPS6KA1(4), RPS6KA2(4), RPS6KB1(2), SERPINB6(2), SFN(1), SHC1(1), SLC2A4(6), SORBS1(8), SOS1(6), SOS2(3), YWHAG(1), YWHAQ(2)	11952644	184	78	174	82	98	19	10	19	38	0	0.205	1.000	1.000
200	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(1), ATF2(5), DLD(1), DUSP10(6), DUSP4(1), DUSP8(1), GAB1(3), GCK(10), IL1R1(7), JUN(1), MAP2K4(3), MAP2K5(2), MAP2K7(2), MAP3K10(5), MAP3K11(4), MAP3K12(3), MAP3K13(5), MAP3K2(4), MAP3K3(4), MAP3K4(11), MAP3K5(11), MAP3K9(17), MAPK10(6), MAPK7(2), MAPK9(1), NFATC3(6), NR2C2(2), PAPPA(39), SHC1(1), TP53(26), TRAF6(2), ZAK(5)	10069099	197	78	192	80	139	16	7	17	18	0	0.0941	1.000	1.000
201	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AKR1A1(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(5), ALDH9A1(2), ALDOA(1), ALDOB(8), ALDOC(1), BPGM(1), DLAT(2), DLD(1), ENO1(2), ENO3(2), FBP1(1), FBP2(1), G6PC(4), GCK(10), GPI(2), HK1(1), HK2(5), HK3(10), LDHA(2), LDHC(3), PDHA1(1), PDHA2(9), PDHB(1), PGK1(2), PGM1(2), PGM3(1), PKLR(6), PKM2(5)	9795600	196	77	187	87	142	16	9	15	14	0	0.00221	1.000	1.000
202	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AKR1A1(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(5), ALDH9A1(2), ALDOA(1), ALDOB(8), ALDOC(1), BPGM(1), DLAT(2), DLD(1), ENO1(2), ENO3(2), FBP1(1), FBP2(1), G6PC(4), GCK(10), GPI(2), HK1(1), HK2(5), HK3(10), LDHA(2), LDHC(3), PDHA1(1), PDHA2(9), PDHB(1), PGK1(2), PGM1(2), PGM3(1), PKLR(6), PKM2(5)	9795600	196	77	187	87	142	16	9	15	14	0	0.00221	1.000	1.000
203	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(4), CANX(1), CD4(4), CD74(3), CD8A(2), CD8B(6), CIITA(10), CTSS(3), HLA-A(2), HLA-B(4), HLA-C(1), HLA-DMA(2), HLA-DMB(4), HLA-DOA(4), HLA-DOB(1), HLA-DPA1(1), HLA-DQA1(4), HLA-DQA2(2), HLA-DQB1(3), HLA-DRA(7), HLA-DRB1(2), HLA-F(5), HLA-G(3), HSP90AA1(2), HSP90AB1(4), HSPA5(4), IFI30(1), IFNA10(2), IFNA14(6), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(3), KIR2DL1(13), KIR2DL3(4), KIR2DL4(3), KIR2DS4(12), KIR3DL1(15), KIR3DL2(2), KIR3DL3(1), KLRC1(2), KLRC2(1), KLRC3(5), KLRC4(4), KLRD1(4), LGMN(4), LTA(2), NFYA(1), NFYB(1), PDIA3(2), PSME2(4), RFX5(4), RFXANK(1), TAP1(1), TAP2(11), TAPBP(1)	9226657	218	77	214	124	149	22	8	17	22	0	0.321	1.000	1.000
204	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(6), ALOX12(4), ALOX12B(6), ALOX15(4), ALOX15B(5), ALOX5(8), CYP2B6(11), CYP2C18(18), CYP2C19(29), CYP2C8(21), CYP2C9(28), CYP2E1(8), CYP2J2(4), CYP4A11(14), CYP4A22(17), CYP4F2(7), CYP4F3(17), EPHX2(4), GGT1(4), GPX1(2), GPX3(2), GPX5(6), GPX6(7), LTA4H(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PTGDS(2), PTGIS(9), PTGS1(14), PTGS2(6), TBXAS1(8)	7735662	316	76	306	212	249	22	6	18	20	1	0.391	1.000	1.000
205	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(11), ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), ALDH1A3(2), ALDH3A1(4), ALDH3B1(2), ALDH3B2(5), AOC2(5), AOC3(6), AOX1(15), COMT(2), DBH(5), DCT(2), DDC(7), FAH(4), GOT1(4), GOT2(2), HGD(11), HPD(3), MAOA(2), MAOB(7), PNMT(4), TAT(12), TH(7), TPO(30), TYR(5)	6325956	235	76	225	121	186	16	12	13	8	0	0.0229	1.000	1.000
206	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(12), AXIN1(6), CCND1(1), CCND2(4), CCND3(1), CSNK1E(3), CTNNB1(6), DVL2(3), DVL3(5), FBXW2(1), FZD1(1), FZD10(1), FZD2(4), FZD5(1), FZD6(2), FZD7(2), FZD8(3), GSK3B(2), JUN(1), LDLR(10), MAPK10(6), MAPK9(1), MYC(2), PAFAH1B1(2), PLAU(2), PPP2R5C(2), PPP2R5E(2), PRKCA(8), PRKCD(2), PRKCE(4), PRKCG(10), PRKCH(5), PRKCI(5), PRKCQ(12), PRKCZ(1), PRKD1(2), RAC1(9), SFRP4(4), TCF7(1), WNT1(1), WNT10A(4), WNT10B(4), WNT11(2), WNT16(1), WNT2(6), WNT2B(2), WNT3(4), WNT4(2), WNT5A(5), WNT5B(2), WNT6(2), WNT7A(10), WNT7B(2)	11932958	196	76	188	106	129	20	4	21	22	0	0.284	1.000	1.000
207	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(10), BMPR1B(2), CCND2(4), CDK4(2), CDKN1B(1), DAZL(3), DMC1(4), EGR1(1), ESR2(5), FSHR(12), GJA4(3), INHA(3), LHCGR(14), MLH1(5), MSH5(5), NCOR1(14), NR5A1(6), NRIP1(5), PGR(10), PRLR(22), PTGER2(5), SMPD1(1), VDR(2), ZP2(9)	6990418	148	75	135	79	105	9	3	14	17	0	0.661	1.000	1.000
208	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(36), B3GALT4(1), CDR1(8), DGKI(14), IL6ST(6), MRPL19(1), PIGK(4), RPL10(2), RPL11(1), RPL13A(1), RPL14(1), RPL15(2), RPL18(3), RPL18A(1), RPL21(1), RPL22(1), RPL26(1), RPL27(2), RPL27A(1), RPL3(1), RPL30(1), RPL35(1), RPL38(1), RPL3L(3), RPL4(4), RPL5(3), RPL7(2), RPL7A(1), RPLP0(1), RPS10(1), RPS11(1), RPS13(1), RPS2(1), RPS20(2), RPS24(1), RPS27(1), RPS29(1), RPS5(1), RPS6(1), RPS6KA1(4), RPS6KA2(4), RPS6KA6(5), RPS6KB1(2), RPS6KB2(2), RPS7(1), RPSA(1), SLC36A2(6), TBC1D10C(3), TSPAN9(1), UBC(4)	10389189	149	75	147	99	95	15	7	17	15	0	0.906	1.000	1.000
209	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(3), BAX(1), BCL2(2), BCL2L11(3), BIRC2(4), BIRC3(6), BIRC5(1), BNIP3L(2), CASP1(3), CASP10(4), CASP2(1), CASP3(1), CASP4(1), CASP7(4), CASP8(2), CASP9(3), CHUK(1), CYCS(1), DFFA(1), DFFB(2), FAS(3), FASLG(10), GZMB(2), HELLS(3), IKBKB(2), IRF2(4), IRF3(3), IRF4(2), IRF5(2), IRF6(8), IRF7(5), JUN(1), LTA(2), MAP2K4(3), MAPK10(6), MDM2(2), MYC(2), NFKB1(3), NFKBIA(2), NFKBIB(1), PLEKHG5(8), PRF1(6), RELA(2), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(7), TNFRSF25(4), TNFSF10(5), TP53(26), TP73(4), TRAF1(6), TRAF2(2), TRAF3(3)	11448323	191	74	188	100	126	17	13	15	20	0	0.376	1.000	1.000
210	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(11), AGMAT(3), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH4A1(5), ALDH9A1(2), AOC2(5), AOC3(6), ARG1(1), ARG2(1), ASL(3), CKM(2), CKMT1A(1), CKMT2(5), CPS1(13), DAO(8), GAMT(3), GATM(2), GLUD1(1), GOT1(4), GOT2(2), MAOA(2), MAOB(7), NOS1(38), NOS3(13), OAT(1), ODC1(2), OTC(2), P4HA1(6), P4HA2(4), P4HA3(10), P4HB(2), RARS(5), SMS(1)	8809036	195	74	190	116	140	20	11	8	16	0	0.336	1.000	1.000
211	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(1), CAMK1(4), CAMK1G(9), ELK1(1), FPR1(15), GNA15(2), HRAS(1), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K6(2), MAPK1(3), MAPK14(4), MAPK3(1), NCF2(5), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NFKB1(3), NFKBIA(2), PAK1(2), PIK3C2G(32), PLCB1(33), PPP3CA(4), PPP3CB(1), PPP3CC(1), RAC1(9), RAF1(2), RELA(2), SYT1(12)	7618938	194	74	180	89	150	12	5	12	15	0	0.0824	1.000	1.000
212	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(3), ALAS2(2), BLVRA(1), BLVRB(1), COX10(4), COX15(2), CP(10), CPOX(2), EPRS(6), FECH(2), FTH1(2), FTMT(4), GUSB(3), HCCS(2), HMBS(1), HMOX1(1), MMAB(2), PPOX(2), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2A1(12), UGT2A3(17), UGT2B10(20), UGT2B11(11), UGT2B15(18), UGT2B28(15), UGT2B4(23), UGT2B7(13), UROS(1)	8430852	230	74	223	89	160	20	10	13	27	0	0.00190	1.000	1.000
213	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(4), ADAM17(1), ATP6AP1(1), ATP6V0A1(5), ATP6V0A4(12), ATP6V0D2(7), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C2(6), ATP6V1E2(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), CASP3(1), CHUK(1), CSK(1), EGFR(16), F11R(4), GIT1(4), IGSF5(6), IKBKB(2), IL8(1), JAM2(9), JAM3(1), JUN(1), LYN(3), MAP2K4(3), MAP3K14(1), MAPK10(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK9(1), MET(12), NFKB1(3), NFKB2(3), NFKBIA(2), NOD1(3), PAK1(2), PLCG1(4), PLCG2(15), PTPN11(5), PTPRZ1(14), RAC1(9), RELA(2), SRC(1), TCIRG1(3), TJP1(9)	14121019	215	74	210	142	149	19	6	23	18	0	0.916	1.000	1.000
214	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), AKT2(6), AKT3(3), BCL2(2), BCR(6), BLNK(11), BTK(8), CD19(5), CD22(16), CD81(2), CR2(20), CSK(1), DAG1(3), FLOT1(1), GRB2(2), GSK3B(2), INPP5D(22), ITPR1(19), ITPR2(10), ITPR3(4), LYN(3), MAP4K1(6), MAPK1(3), MAPK3(1), NFATC1(13), NFATC2(6), NR0B2(6), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3R1(2), PLCG2(15), PPP1R13B(5), PPP3CA(4), PPP3CB(1), PPP3CC(1), PTPRC(18), RAF1(2), SHC1(1), SOS1(6), SOS2(3), SYK(11), VAV1(13)	14785674	269	74	262	130	197	23	12	16	21	0	0.0228	1.000	1.000
215	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(6), ABP1(11), ACADL(2), ACADM(5), ACADSB(3), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), AOC2(5), AOC3(6), CNDP1(7), DPYD(38), DPYS(15), EHHADH(5), GAD1(7), GAD2(4), HADHA(7), MLYCD(2), SMS(1), UPB1(5)	5831648	155	73	148	75	110	11	9	15	10	0	0.105	1.000	1.000
216	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(4), F11(9), F12(1), F13B(16), F2(6), F5(20), F7(2), F8(29), F9(6), FGA(20), FGB(7), FGG(4), LPA(28), PLAT(2), PLAU(2), PLG(20), SERPINB2(8), SERPINE1(2), SERPINF2(3), VWF(32)	7026025	221	73	214	98	160	16	14	11	19	1	0.113	1.000	1.000
217	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(4), BMP4(2), BMP5(12), BMP6(8), BMP7(2), BTRC(4), CSNK1A1(2), CSNK1A1L(3), CSNK1D(1), CSNK1E(3), CSNK1G1(1), CSNK1G2(2), FBXW11(4), GLI1(9), GLI2(23), GLI3(8), GSK3B(2), HHIP(13), IHH(2), LRP2(59), PRKACA(2), PRKACB(2), PRKACG(7), PRKX(1), PTCH1(4), PTCH2(12), SHH(2), SMO(6), STK36(12), SUFU(2), WNT1(1), WNT10A(4), WNT10B(4), WNT11(2), WNT16(1), WNT2(6), WNT2B(2), WNT3(4), WNT3A(5), WNT4(2), WNT5A(5), WNT5B(2), WNT6(2), WNT7A(10), WNT7B(2), WNT8A(4), WNT8B(5), WNT9A(1), WNT9B(3), ZIC2(1)	12056305	280	73	268	152	201	27	9	21	22	0	0.211	1.000	1.000
218	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(5), AKT1(1), APC(12), CAMP(1), DAG1(3), DLG4(4), EPHB2(17), GNAI1(1), GNAQ(1), ITPR1(19), ITPR2(10), ITPR3(4), KCNJ3(14), KCNJ5(6), KCNJ9(4), MAPK1(3), PITX2(1), RAC1(9), RHO(2), RYR1(61)	9111261	178	73	172	120	134	17	6	10	11	0	0.555	1.000	1.000
219	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(33), COL4A2(20), COL4A3(24), COL4A4(58), COL4A5(41), COL4A6(28), P4HB(2), SLC23A1(3), SLC23A2(1), SLC2A1(3), SLC2A3(4)	4986954	217	73	210	62	184	9	7	8	9	0	0.241	1.000	1.000
220	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(12), CANT1(8), CDA(2), CTPS(2), CTPS2(2), DCTD(1), DHODH(1), DPYD(38), DPYS(15), ENTPD1(5), NT5E(4), NT5M(1), POLD1(3), POLD2(2), POLE(10), POLG(4), POLL(7), POLQ(15), POLR1B(5), POLR2A(10), POLR2B(11), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(1), RRM1(3), TK2(1), TXNRD1(3), TYMS(1), UCK1(2), UMPS(1), UNG(2), UPB1(5)	11500534	184	72	175	78	118	14	10	23	19	0	0.0207	1.000	1.000
221	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(4), ACTG2(1), ACTR2(2), AKT1(1), ANGPTL2(2), CFL1(1), FLNA(8), FLNC(37), FSCN1(4), FSCN2(1), FSCN3(9), GDI2(1), LIMK1(4), MYH2(53), MYLK(22), MYLK2(6), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), RHO(2), ROCK1(3), ROCK2(4), VASP(1), WASF1(1), WASL(3)	9550532	218	72	208	125	159	29	6	13	11	0	0.170	1.000	1.000
222	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(1), AKT2(6), AKT3(3), BTK(8), CDKN2A(23), DAPP1(4), GRB2(2), GSK3B(2), IARS(5), IGFBP1(2), INPP5D(22), PDK1(1), PIK3CA(2), PPP1R13B(5), PTEN(12), RPS6KA1(4), RPS6KA2(4), RPS6KB1(2), SFN(1), SHC1(1), SOS1(6), SOS2(3), TEC(7), YWHAG(1), YWHAQ(2)	7219897	130	72	118	41	67	9	10	11	33	0	0.0208	1.000	1.000
223	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(3), UGP2(1), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2A1(12), UGT2A3(17), UGT2B10(20), UGT2B11(11), UGT2B15(18), UGT2B28(15), UGT2B4(23), UGT2B7(13), XYLB(2)	5439826	187	71	180	75	133	14	9	11	20	0	0.0103	1.000	1.000
224	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(6), ABP1(11), ACADM(5), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), AOC2(5), AOC3(6), CNDP1(7), DPYD(38), DPYS(15), EHHADH(5), GAD1(7), GAD2(4), HADHA(7), HIBCH(1), MLYCD(2), SMS(1), UPB1(5)	5424702	142	71	135	72	101	9	9	14	9	0	0.166	1.000	1.000
225	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(5), ALOX15(4), ALOX5(8), CYP1A2(8), CYP2C18(18), CYP2C19(29), CYP2C8(21), CYP2C9(28), CYP2E1(8), CYP2J2(4), CYP3A4(13), CYP3A43(10), CYP3A5(4), CYP3A7(14), HSD3B7(1), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), RDH12(1), RDH13(3)	4777442	222	71	214	130	179	9	6	11	17	0	0.115	1.000	1.000
226	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), ABO(4), B3GALNT1(5), B3GALT1(10), B3GALT2(1), B3GALT4(1), B3GALT5(1), B3GNT1(2), B3GNT2(2), B3GNT3(4), B3GNT4(2), B3GNT5(1), B4GALNT1(1), B4GALT1(1), B4GALT2(2), B4GALT3(2), B4GALT6(1), FUT1(3), FUT2(2), FUT3(4), FUT4(1), FUT5(6), FUT6(1), FUT7(2), FUT9(14), GBGT1(1), PIGB(3), PIGC(1), PIGF(2), PIGG(9), PIGK(4), PIGL(2), PIGN(2), PIGO(9), PIGQ(6), PIGS(1), PIGT(1), PIGU(4), PIGV(7), PIGX(1), PIGZ(1), ST3GAL1(5), ST3GAL4(1), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(4), ST6GALNAC5(5), ST6GALNAC6(2), ST8SIA5(5), UGCG(1)	9693273	157	70	155	88	97	16	11	17	16	0	0.292	1.000	1.000
227	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(29), C5(9), C6(39), C7(25), ICAM1(2), IL1A(3), IL8(1), ITGA4(26), ITGAL(17), ITGB1(4), ITGB2(10), SELP(15), SELPLG(4), TNF(1), VCAM1(13)	4923296	198	70	185	89	153	6	6	15	17	1	0.0250	1.000	1.000
228	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), AKT2(6), AKT3(3), BCR(6), BLNK(11), BTK(8), CD19(5), CSK(1), DAG1(3), EPHB2(17), GRB2(2), ITPKB(5), LYN(3), MAP2K1(7), MAP2K2(2), MAPK1(3), NFAT5(3), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PI3(6), PIK3CA(2), PIK3CD(2), PIK3R1(2), PLCG2(15), PPP1R13B(5), RAF1(2), SERPINA4(10), SHC1(1), SOS1(6), SOS2(3), SYK(11), VAV1(13)	10588268	176	70	171	102	123	15	10	15	13	0	0.576	1.000	1.000
229	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(3), C1QB(2), C1R(9), C1S(15), C2(9), C3(29), C5(9), C6(39), C7(25), C8A(27), C8B(30), C9(14), MASP1(6)	4118678	217	69	199	90	176	12	4	13	11	1	0.00508	1.000	1.000
230	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(3), ATM(10), ATR(13), CCNA1(12), CCND1(1), CCNE1(3), CDC25A(6), CDK4(2), CDK6(1), CDKN1A(2), CDKN1B(1), CDKN2A(23), E2F1(5), GSK3B(2), HDAC1(1), RB1(3), TFDP1(1), TGFB2(1), TGFB3(1), TP53(26)	6060926	117	69	103	36	60	3	8	11	33	2	0.0147	1.000	1.000
231	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(38), GABBR1(4), GPRC5A(2), GPRC5B(3), GPRC5C(7), GPRC5D(2), GRM1(9), GRM2(3), GRM3(39), GRM4(15), GRM5(9), GRM7(21), GRM8(28)	4183956	180	69	170	136	138	14	5	11	12	0	0.445	1.000	1.000
232	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(3), AANAT(1), ABP1(11), ACAT2(1), ACMSD(7), AFMID(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), AOC2(5), AOC3(6), AOX1(15), ASMT(4), CARM1(4), CAT(4), CYP1A1(8), CYP1A2(8), CYP1B1(1), DDC(7), EHHADH(5), GCDH(3), HAAO(3), HADHA(7), HEMK1(1), HSD17B10(1), HSD17B4(3), INMT(5), KMO(5), KYNU(6), LCMT1(4), LNX1(12), MAOA(2), MAOB(7), METTL2B(6), NFX1(4), OGDH(8), OGDHL(22), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), TDO2(2), TPH1(2), TPH2(9), WARS(3), WARS2(1), WBSCR22(1)	12122081	245	69	239	132	181	19	12	21	12	0	0.206	1.000	1.000
233	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(3), CRK(2), DOCK1(13), ELK1(1), FOS(1), GAB1(3), GRB2(2), HGF(13), HRAS(1), ITGA1(15), ITGB1(4), JUN(1), MAP2K1(7), MAP2K2(2), MAP4K1(6), MAPK1(3), MAPK3(1), MET(12), PAK1(2), PIK3CA(2), PIK3R1(2), PTEN(12), PTK2(3), PTK2B(7), PTPN11(5), PXN(3), RAF1(2), RAP1A(1), RASA1(1), SOS1(6), SRC(1), STAT3(6)	8729941	143	69	138	69	87	9	6	24	17	0	0.667	1.000	1.000
234	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(6), CD3D(5), CSK(1), CTLA4(1), DAG1(3), EPHB2(17), FBXW7(9), GRAP2(1), GRB2(2), ITK(19), ITPKB(5), LCK(9), LCP2(5), MAPK1(3), NFAT5(3), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PAK1(2), PAK2(2), PAK3(5), PAK4(4), PAK6(2), PAK7(33), PLCG1(4), PTPRC(18), RAF1(2), RASGRP1(7), RASGRP2(3), RASGRP3(8), RASGRP4(9), SOS1(6), SOS2(3), VAV1(13), ZAP70(4)	11082613	226	69	218	119	160	16	9	22	19	0	0.393	1.000	1.000
235	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(4), AKR1D1(14), ARSD(2), ARSE(4), CYP11B1(8), CYP11B2(9), HSD11B1(8), HSD17B2(7), HSD17B3(5), HSD3B1(4), HSD3B2(9), SRD5A1(2), SRD5A2(5), STS(3), SULT1E1(10), SULT2A1(4), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2B15(18), UGT2B4(23)	5451237	189	68	179	87	127	19	8	11	24	0	0.0126	1.000	1.000
236	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(3), ACAA2(1), ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AKR1C4(4), AKR1D1(14), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), BAAT(6), CEL(6), CYP27A1(2), CYP7A1(5), HADHB(2), SOAT2(4), SRD5A1(2), SRD5A2(5)	4679070	158	68	148	59	106	16	8	14	14	0	0.00104	1.000	1.000
237	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(1), B4GALT2(2), FBP2(1), G6PC(4), GAA(5), GALK1(1), GALK2(1), GALT(2), GANAB(5), GCK(10), GLA(1), GLB1(5), HK1(1), HK2(5), HK3(10), LALBA(5), LCT(31), MGAM(89), PGM1(2), PGM3(1)	6507015	184	68	176	101	139	19	4	15	7	0	0.105	1.000	1.000
238	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(3), ACAA2(1), ACAD8(1), ACAD9(1), ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), AKR1B10(5), AKR1C4(4), AKR1D1(14), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), BAAT(6), CEL(6), CYP27A1(2), CYP7A1(5), HADHB(2), HSD3B7(1), LIPA(1), RDH12(1), RDH13(3), SLC27A5(4), SOAT1(3), SOAT2(4), SRD5A1(2), SRD5A2(5)	6370495	169	68	159	76	115	16	11	13	14	0	0.0129	1.000	1.000
239	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(22), ATP4A(10), ATP4B(1), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(6), ATP5H(1), ATP5O(3), ATP6AP1(1), ATP6V0A1(5), ATP6V0A4(12), ATP6V0D2(7), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C2(6), ATP6V1E2(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), COX10(4), COX15(2), COX4I2(1), COX5B(1), COX6B1(1), COX7B(1), COX7B2(1), COX8A(1), CYC1(3), LHPP(1), NDUFA10(1), NDUFA12(1), NDUFA13(5), NDUFA9(2), NDUFAB1(1), NDUFB2(1), NDUFB5(1), NDUFB6(2), NDUFC2(1), NDUFS2(1), NDUFS3(1), NDUFS4(2), NDUFS5(1), NDUFS6(1), NDUFS7(3), NDUFS8(3), NDUFV1(1), PPA1(1), PPA2(2), SDHA(1), SDHC(2), TCIRG1(3), UQCRC1(3), UQCRFS1(2)	11245773	156	68	151	87	100	16	9	18	13	0	0.483	1.000	1.000
240	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(5), AGPAT2(3), AGPAT3(3), AGPAT4(5), AGPAT6(2), CDS1(6), CDS2(4), CHAT(11), CHKA(2), CHKB(2), CHPT1(1), DGKA(1), DGKB(16), DGKD(5), DGKE(5), DGKG(10), DGKH(6), DGKI(14), DGKQ(3), DGKZ(6), GNPAT(2), GPAM(5), GPD1(7), GPD1L(2), GPD2(1), LYPLA1(1), LYPLA2(1), MYST3(10), MYST4(11), NAT6(2), PCYT1A(2), PCYT1B(3), PEMT(1), PISD(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PLD1(7), PLD2(3), PNPLA3(1), PPAP2B(4), PPAP2C(6), SH3GLB1(2)	13083949	226	68	217	117	155	21	7	20	23	0	0.258	1.000	1.000
241	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(3), C1QB(2), C1R(9), C1S(15), C2(9), C3(29), C5(9), C6(39), C7(25), C8A(27), C9(14), MASP1(6), MASP2(7), MBL2(8)	4222656	202	67	186	85	163	10	2	13	13	1	0.00973	1.000	1.000
242	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(5), B4GALT1(1), B4GALT2(2), G6PC(4), G6PC2(2), GAA(5), GALK1(1), GALK2(1), GALT(2), GANC(2), GCK(10), GLA(1), GLB1(5), HK1(1), HK2(5), HK3(10), HSD3B7(1), LALBA(5), LCT(31), MGAM(89), PFKL(2), PGM1(2), PGM3(1), RDH12(1), RDH13(3), UGP2(1)	7715250	195	67	187	112	150	18	3	15	9	0	0.143	1.000	1.000
243	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), DLG4(4), GRIN1(6), GRIN2A(57), GRIN2B(32), GRIN2C(7), GRIN2D(4), NOS1(38), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), SYT1(12)	5092308	192	66	187	124	149	15	3	12	13	0	0.411	1.000	1.000
244	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(6), ALOX12(4), ALOX15(4), ALOX5(8), CYP4F2(7), CYP4F3(17), EPX(5), GGT1(4), LPO(11), LTA4H(2), MPO(6), PLA2G2A(2), PLA2G2E(2), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PRDX1(1), PRDX2(2), PRDX6(2), PTGDS(2), PTGIS(9), PTGS1(14), PTGS2(6), TBXAS1(8), TPO(30)	5589717	181	66	177	108	139	14	3	14	11	0	0.135	1.000	1.000
245	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(2), C1GALT1(5), C1GALT1C1(1), GALNT1(2), GALNT10(4), GALNT11(1), GALNT12(5), GALNT13(12), GALNT14(16), GALNT2(4), GALNT3(2), GALNT4(2), GALNT5(9), GALNT6(13), GALNT7(5), GALNT8(14), GALNT9(3), GALNTL1(2), GALNTL2(13), GALNTL4(1), GALNTL5(13), GCNT1(4), GCNT3(3), OGT(5), ST3GAL1(5), ST6GALNAC1(3), WBSCR17(24)	6475375	173	65	168	79	127	10	2	14	20	0	0.0937	1.000	1.000
246	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(3), APOA1(2), CD36(3), CPT1B(6), CREBBP(14), EHHADH(5), EP300(8), FABP1(3), HSD17B4(3), JUN(1), LPL(2), MAPK1(3), MAPK3(1), ME1(14), MYC(2), NCOA1(8), NCOR1(14), NCOR2(15), NFKBIA(2), NR0B2(6), NR1H3(2), NR2F1(7), NRIP1(5), PDGFA(1), PIK3CA(2), PIK3R1(2), PPARA(4), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), PTGS2(6), RB1(3), RELA(2), RXRA(1), SP1(4), STAT5A(2), STAT5B(4), TNF(1)	12719184	186	65	182	91	128	16	13	14	13	2	0.315	1.000	1.000
247	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(3), C1QB(2), C1R(9), C1S(15), C2(9), C3(29), C5(9), C6(39), C7(25), C8A(27), C9(14)	3458389	181	64	165	74	145	9	2	13	11	1	0.0112	1.000	1.000
248	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(5), AGPAT2(3), AGPAT3(3), AGPAT4(5), AGPS(3), CDS1(6), CDS2(4), CHAT(11), CHKA(2), CHKB(2), CLC(2), CPT1B(6), DGKA(1), DGKB(16), DGKD(5), DGKE(5), DGKG(10), DGKH(6), DGKQ(3), DGKZ(6), GNPAT(2), GPD1(7), GPD2(1), LGALS13(2), LYPLA1(1), LYPLA2(1), PAFAH1B1(2), PAFAH2(2), PCYT1A(2), PCYT1B(3), PEMT(1), PISD(2), PLA2G2A(2), PLA2G2E(2), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PLCB2(7), PLCG1(4), PLCG2(15), PPAP2B(4), PPAP2C(6)	9999785	199	64	194	99	149	13	4	17	16	0	0.0341	1.000	1.000
249	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(4), APAF1(3), ARHGDIB(2), BAG4(1), BCL2(2), BIRC2(4), BIRC3(6), CASP2(1), CASP3(1), CASP7(4), CASP8(2), CASP9(3), CFLAR(3), CHUK(1), CRADD(1), CYCS(1), DAXX(5), DFFA(1), DFFB(2), GSN(5), LMNA(3), LMNB1(1), LMNB2(4), MAP2K7(2), MAP3K14(1), MAP3K5(11), MDM2(2), NFKB1(3), NFKBIA(2), NUMA1(5), PAK2(2), PRKCD(2), PRKDC(13), PSEN1(1), PSEN2(2), PTK2(3), RASA1(1), RB1(3), RELA(2), RIPK1(1), SPTAN1(4), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF1(6), TRAF2(2)	13877634	132	64	131	69	73	14	11	18	14	2	0.531	1.000	1.000
250	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(3), ALPL(6), ALPP(6), ALPPL2(7), ASCC3(5), ATP13A2(7), DDX18(4), DDX19A(1), DDX23(5), DDX4(8), DDX41(4), DDX47(1), DDX50(2), DDX51(3), DDX52(3), DDX54(2), DDX55(2), DDX56(2), DHX58(4), ENTPD7(1), EP400(16), ERCC2(1), ERCC3(3), FPGS(3), GGH(2), IFIH1(8), MOV10L1(17), NUDT5(1), NUDT8(1), QDPR(1), RAD54B(5), RUVBL2(2), SETX(13), SKIV2L2(3), SMARCA2(9), SMARCA5(3), SPR(1)	12499328	165	64	158	84	106	11	5	22	21	0	0.414	1.000	1.000
251	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(5), BCR(6), BLNK(11), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(1), LYN(3), MAP2K1(7), MAPK1(3), MAPK3(1), MAPK8IP3(6), PAPPA(39), RAC1(9), RPS6KA1(4), SHC1(1), SOS1(6), SYK(11), VAV1(13), VAV2(3), VAV3(6)	6367392	140	64	131	72	106	9	3	14	8	0	0.288	1.000	1.000
252	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(8), CALM2(1), ELK1(1), FCER1A(8), FCER1G(1), FOS(1), GRB2(2), HRAS(1), JUN(1), LYN(3), MAP2K1(7), MAP2K4(3), MAP2K7(2), MAPK1(3), MAPK3(1), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), PAK2(2), PIK3CA(2), PIK3R1(2), PLA2G4A(8), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), RAF1(2), SHC1(1), SOS1(6), SYK(11), SYT1(12), VAV1(13)	8592191	142	63	137	72	106	9	8	11	8	0	0.499	1.000	1.000
253	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(2), CARS(6), CARS2(1), DARS(2), DARS2(1), EPRS(6), FARS2(3), FARSA(5), FARSB(5), GARS(5), HARS(3), HARS2(2), IARS(5), IARS2(10), KARS(3), LARS(8), LARS2(3), MARS(5), MARS2(3), MTFMT(1), NARS(2), NARS2(4), QARS(6), RARS(5), RARS2(1), SARS(4), SARS2(2), TARS(1), TARS2(7), VARS(14), VARS2(4), WARS(3), WARS2(1), YARS(1), YARS2(1)	11002468	139	63	132	60	84	17	7	14	17	0	0.104	1.000	1.000
254	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), AKT2(6), AKT3(3), ANKRD6(3), APC(12), AXIN1(6), AXIN2(2), CER1(7), CSNK1A1(2), CTNNB1(6), DACT1(5), DKK1(1), DKK2(9), DKK3(3), DKK4(1), FSTL1(2), GSK3B(2), LRP1(22), MVP(4), NKD1(5), NKD2(4), PIN1(1), PSEN1(1), PTPRA(3), SENP2(9), TSHB(3), WIF1(5)	7998556	128	63	127	70	74	18	5	15	16	0	0.650	1.000	1.000
255	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(3), CALM2(1), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CDK5(3), F2(6), FYN(5), GNA11(6), GNAI1(1), GRB2(2), HRAS(1), JAK2(6), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK14(4), MAPK3(1), MAPT(7), MYLK(22), PLCG1(4), PRKCA(8), PTK2B(7), RAF1(2), SHC1(1), SOS1(6), STAT1(2), STAT3(6), STAT5A(2), SYT1(12)	8303608	145	62	141	97	98	12	7	16	12	0	0.886	1.000	1.000
256	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT2(6), AKT3(3), ARHGEF11(10), BCL2(2), DLG4(4), GNA13(1), LPA(28), MAP2K4(3), MAP3K5(11), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PDK1(1), PHKA2(6), PI3(6), PIK3CB(10), PLD1(7), PLD2(3), PLD3(1), PTK2(3), ROCK1(3), ROCK2(4), SERPINA4(10), SRF(1), TBXA2R(3)	9819347	139	62	135	76	83	12	6	23	15	0	0.722	1.000	1.000
257	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(8), ALDOC(1), DLAT(2), DLD(1), ENO1(2), ENO3(2), FBP1(1), FBP2(1), G6PC(4), GCK(10), GOT1(4), GOT2(2), GPI(2), HK1(1), HK2(5), HK3(10), LDHA(2), LDHAL6B(6), LDHC(3), MDH1(1), MDH2(2), PC(6), PCK1(20), PDHA1(1), PDHA2(9), PDHB(1), PDHX(2), PFKL(2), PGK1(2), PGK2(17), PKLR(6), PKM2(5)	8534309	142	61	136	74	111	7	8	6	10	0	0.0222	1.000	1.000
258	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(4), AARS2(2), ABAT(6), ACY3(1), ADSL(6), ADSS(1), ADSSL1(4), AGXT(8), AGXT2(13), ASL(3), ASNS(7), ASPA(3), ASRGL1(1), ASS1(3), CAD(12), CRAT(4), DARS(2), DARS2(1), DDO(4), DLAT(2), DLD(1), GAD1(7), GAD2(4), GOT1(4), GOT2(2), GPT(3), NARS(2), NARS2(4), PC(6), PDHA1(1), PDHA2(9), PDHB(1)	7614721	131	61	128	71	92	12	8	14	5	0	0.292	1.000	1.000
259	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(3), AASDHPPT(1), AASS(1), ACAT2(1), AKR1B10(5), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), BBOX1(3), DOT1L(5), EHHADH(5), EHMT1(6), EHMT2(4), GCDH(3), HADHA(7), HSD17B10(1), HSD17B4(3), HSD3B7(1), NSD1(10), OGDH(8), OGDHL(22), PIPOX(3), PLOD1(1), PLOD2(5), PLOD3(1), RDH12(1), RDH13(3), SETD1A(17), SETD7(1), SETDB1(1), SHMT2(2), SUV39H1(1), TMLHE(1)	11586538	143	61	141	71	98	13	7	15	10	0	0.218	1.000	1.000
260	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(16), ACACB(14), ACAT2(1), ACOT12(8), ACSS2(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), DLAT(2), DLD(1), GLO1(1), HAGH(1), LDHA(2), LDHAL6A(1), LDHAL6B(6), LDHC(3), LDHD(1), MDH1(1), MDH2(2), ME1(14), ME2(1), ME3(6), PC(6), PCK1(20), PCK2(3), PDHA1(1), PDHA2(9), PDHB(1), PKLR(6), PKM2(5)	9403502	154	61	151	72	107	10	8	14	15	0	0.0436	1.000	1.000
261	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(2), CHUK(1), DAXX(5), EGF(14), EGFR(16), ETS1(3), ETS2(8), FOS(1), HOXA7(2), HRAS(1), IKBKB(2), JUN(1), MAP2K1(7), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP2K7(2), MAP3K14(1), MAP3K5(11), MAPK1(3), MAPK13(4), MAPK14(4), MAPK3(1), NFKB1(3), NFKBIA(2), PPP2CA(1), PRKCA(8), PRKCD(2), PRKCE(4), PRKCG(10), PRKCH(5), PRKCQ(12), RAF1(2), RELA(2), RIPK1(1), SP1(4), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2)	9805853	160	61	156	105	113	12	5	16	14	0	0.903	1.000	1.000
262	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(6), F2R(4), GNAI1(1), HRAS(1), ITGA1(15), ITGB1(4), MAP2K1(7), MAPK1(3), MAPK3(1), PLA2G4A(8), PLCB1(33), PRKCA(8), PTGS1(14), PTK2(3), RAF1(2), SRC(1), SYK(11), TBXAS1(8)	4878974	130	61	121	61	98	8	3	14	7	0	0.157	1.000	1.000
263	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(29), C5(9), C6(39), C7(25), C8A(27), C9(14)	2481891	143	60	129	56	117	6	2	8	9	1	0.0195	1.000	1.000
264	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(10), ATR(13), BRCA1(6), BRCA2(12), CHEK1(1), FANCA(2), FANCC(3), FANCD2(11), FANCE(2), FANCF(1), FANCG(3), HUS1(1), MRE11A(3), RAD1(2), RAD17(4), RAD50(3), RAD9A(4), TP53(26)	8862282	107	60	102	42	70	1	6	12	18	0	0.349	1.000	1.000
265	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(8), CFL1(1), GNAQ(1), GNAS(12), HRAS(1), LIMK1(4), MAP2K1(7), MAPK1(3), MAPK3(1), MYL2(4), NOX1(7), PIK3C2G(32), PLCB1(33), PPP1R12B(5), PRKCA(8), PTK2(3), RAF1(2), ROCK2(4)	5018971	137	60	126	55	105	3	2	19	8	0	0.0656	1.000	1.000
266	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(11), AGXT(8), AGXT2(13), AKR1B10(5), ALAS2(2), AMT(1), AOC2(5), AOC3(6), BHMT(6), CBS(5), CHDH(7), CHKA(2), CHKB(2), DAO(8), DLD(1), DMGDH(9), GAMT(3), GARS(5), GATM(2), GCAT(3), GLDC(2), GNMT(1), HSD3B7(1), MAOA(2), MAOB(7), PEMT(1), PHGDH(10), PIPOX(3), PISD(2), PSAT1(1), RDH12(1), RDH13(3), SARDH(9), SARS(4), SARS2(2), SHMT2(2), TARS(1), TARS2(7)	8566724	163	60	155	90	120	9	6	12	16	0	0.170	1.000	1.000
267	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(5), ARG1(1), ARG2(1), ASL(3), ASS1(3), CKM(2), CKMT1A(1), CKMT2(5), CPS1(13), DAO(8), EPRS(6), GAMT(3), GATM(2), GLUD1(1), GLUD2(1), GOT1(4), GOT2(2), NOS1(38), NOS3(13), OAT(1), OTC(2), P4HA1(6), P4HA2(4), P4HA3(10), PRODH(1), PYCR2(1), RARS(5), RARS2(1)	7169380	143	60	138	92	103	13	6	8	13	0	0.695	1.000	1.000
268	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(3), ARRB2(3), CALM2(1), CALML3(3), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CLCA1(4), CLCA2(7), CLCA4(19), CNGA3(17), CNGA4(8), CNGB1(13), GNAL(2), GUCA1A(3), GUCA1B(1), GUCA1C(3), PDC(3), PDE1C(25), PRKACA(2), PRKACB(2), PRKACG(7), PRKG1(7), PRKG2(10), PRKX(1)	6032005	158	60	150	105	113	13	6	17	9	0	0.774	1.000	1.000
269	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), AKT1(1), ANGPTL2(2), DAG1(3), DGKA(1), ETFA(1), GCA(3), ITGA9(9), ITPKB(5), ITPR1(19), ITPR2(10), ITPR3(4), MAP2K1(7), MAPK1(3), MAPK3(1), NR1I3(7), PAK1(2), PDE3A(14), PDE3B(5), PI3(6), PIK3C2G(32), PIK3CA(2), PIK3CD(2), PIK3R1(2), RIPK3(8), VASP(1)	9712036	152	60	145	60	116	11	6	8	11	0	0.00210	1.000	1.000
270	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM2(1), CD3D(5), CD3E(2), ELK1(1), FOS(1), FYN(5), GRB2(2), HRAS(1), JUN(1), LCK(9), MAP2K1(7), MAP2K4(3), MAPK3(1), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), NFKB1(3), NFKBIA(2), PIK3CA(2), PIK3R1(2), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKCA(8), PTPN7(1), RAC1(9), RAF1(2), RASA1(1), RELA(2), SHC1(1), SOS1(6), SYT1(12), VAV1(13), ZAP70(4)	9547551	147	60	139	72	106	15	4	13	9	0	0.406	1.000	1.000
271	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(3), BAX(1), BCL2(2), BIRC2(4), BIRC3(6), CASP2(1), CASP3(1), CASP7(4), CASP8(2), CASP9(3), CYCS(1), FAS(3), FASLG(10), GZMB(2), JUN(1), MAP2K4(3), MAP3K14(1), MAPK10(6), MCL1(2), MDM2(2), MYC(2), NFKB1(3), NFKBIA(2), PARP1(7), PRF1(6), RELA(2), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFSF10(5), TP53(26), TRAF1(6), TRAF2(2)	7465931	124	59	121	52	75	11	11	10	17	0	0.0918	1.000	1.000
272	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(2), ARSE(4), B4GALT6(1), DEGS1(1), DEGS2(3), ENPP7(3), GAL3ST1(7), GALC(1), GBA(2), GLA(1), GLB1(5), LCT(31), NEU1(4), NEU2(12), NEU3(2), NEU4(7), PPAP2B(4), PPAP2C(6), SGMS1(12), SGPP2(5), SMPD1(1), SMPD3(7), SMPD4(4), SPHK1(1), SPHK2(5), SPTLC2(5), UGCG(1), UGT8(5)	7089757	142	59	138	96	109	10	4	13	6	0	0.804	1.000	1.000
273	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(4), ACTG2(1), ADCY3(2), ADCY9(9), AK1(1), ARF4(1), ARF5(1), ARL4D(2), ATP6V0A1(5), ATP6V0A4(12), ATP6V0D2(7), ATP6V1A(2), ATP6V1C2(6), ATP6V1E2(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), ERO1L(4), GNAS(12), PDIA4(3), PLCG1(4), PLCG2(15), PRKCA(8), SEC61A1(2), SEC61A2(4)	7447484	120	59	117	90	85	5	4	14	12	0	0.923	1.000	1.000
274	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(5), ADRA1B(2), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(1), CHRM1(4), CHRM2(10), CHRM3(11), CHRM4(5), CHRM5(2), DRD1(8), DRD2(9), DRD3(1), DRD4(1), DRD5(18), HRH1(11), HRH2(3), HTR1A(7), HTR1D(3), HTR1E(3), HTR1F(5), HTR2A(7), HTR2C(6), HTR4(5), HTR5A(11), HTR6(1), HTR7(7)	5035778	160	59	154	130	107	20	5	14	14	0	0.230	1.000	1.000
275	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(19), AR(7), ESR1(2), ESR2(5), ESRRA(1), HNF4A(15), NPM1(1), NR0B1(2), NR1D2(5), NR1H2(2), NR1H3(2), NR1I2(3), NR1I3(7), NR2C2(2), NR2E1(3), NR2F1(7), NR3C1(2), NR4A1(2), NR4A2(1), NR5A1(6), NR5A2(11), PGR(10), PPARA(4), PPARD(2), PPARG(8), RARA(1), RARB(3), RARG(1), ROR1(9), RORA(3), RORC(5), RXRA(1), RXRB(1), RXRG(3), THRA(1), THRB(12), VDR(2)	8342463	171	59	162	92	130	13	2	13	13	0	0.177	1.000	1.000
276	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(3), ACAA2(1), ACADL(2), ACADM(5), ACADS(2), ACADSB(3), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH6A1(2), ALDH9A1(2), AOX1(15), BCAT1(9), BCKDHA(1), BCKDHB(1), EHHADH(5), HADHA(7), HADHB(2), HIBADH(7), HMGCL(2), IVD(3), MCCC1(5), MCEE(1), MUT(4), OXCT1(3), PCCA(2), PCCB(1)	7254789	113	59	110	54	77	10	3	12	11	0	0.332	1.000	1.000
277	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(10), ATR(13), BRCA1(6), CDC25A(6), CDC25B(3), CDC25C(3), CDC34(3), CDKN1A(2), CHEK1(1), EP300(8), MDM2(2), MYT1(15), PRKDC(13), RPS6KA1(4), TP53(26), WEE1(2), YWHAQ(2)	8446431	119	58	115	46	74	10	7	12	16	0	0.213	1.000	1.000
278	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(11), AGXT(8), AGXT2(13), ALAS2(2), AMT(1), AOC2(5), AOC3(6), BHMT(6), CBS(5), CHDH(7), CHKA(2), CHKB(2), CPT1B(6), DAO(8), DLD(1), DMGDH(9), GAMT(3), GARS(5), GATM(2), GCAT(3), GLDC(2), MAOA(2), MAOB(7), PEMT(1), PISD(2), PLCB2(7), PLCG1(4), PLCG2(15), SARDH(9), SARS(4), SHMT2(2), TARS(1)	8429978	161	58	156	93	124	9	6	8	14	0	0.182	1.000	1.000
279	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(6), ACAA1(3), ACAA2(1), ACADM(5), ACADS(2), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH6A1(2), ALDH7A1(3), ALDH9A1(2), AOX1(15), AUH(3), BCAT1(9), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(1), DLD(1), EHHADH(5), HADHA(7), HADHB(2), HIBADH(7), HIBCH(1), HMGCL(2), HMGCS1(1), HMGCS2(14), HSD17B10(1), HSD17B4(3), IVD(3), MCCC1(5), MCEE(1), MUT(4), OXCT1(3), OXCT2(2), PCCA(2), PCCB(1)	8664368	133	58	129	60	89	12	6	16	10	0	0.218	1.000	1.000
280	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(16), ACAT2(1), AKR1B1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), DLAT(2), DLD(1), GLO1(1), HAGH(1), LDHA(2), LDHC(3), LDHD(1), MDH1(1), MDH2(2), ME1(14), ME2(1), ME3(6), PC(6), PCK1(20), PDHA1(1), PDHA2(9), PDHB(1), PKLR(6), PKM2(5)	7432233	128	58	127	57	91	9	6	11	11	0	0.0516	1.000	1.000
281	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(11), BTK(8), CALM2(1), CD79A(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(1), LYN(3), MAP2K1(7), MAPK14(4), MAPK3(1), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKCA(8), RAC1(9), RAF1(2), SHC1(1), SOS1(6), SYK(11), SYT1(12), VAV1(13)	7656017	144	57	135	65	109	8	5	12	10	0	0.180	1.000	1.000
282	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(17), AKT1(1), GNAI1(1), ITGAV(5), ITGB3(9), MAPK1(3), MAPK3(1), PDGFA(1), PDGFRA(15), PIK3CA(2), PIK3R1(2), PLCB1(33), PRKCA(8), PTK2(3), RAC1(9), SMPD1(1), SPHK1(1), SRC(1)	5524375	113	57	105	51	88	4	4	11	6	0	0.0993	1.000	1.000
283	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(11), ACY3(1), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(5), ALDH7A1(3), ALDH9A1(2), AMDHD1(2), AOC2(5), AOC3(6), ASPA(3), CARM1(4), CNDP1(7), DDC(7), FTCD(1), HAL(8), HARS(3), HARS2(2), HDC(8), HEMK1(1), LCMT1(4), MAOA(2), MAOB(7), METTL2B(6), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), PRPS1(1), PRPS2(1), UROC1(8), WBSCR22(1)	7921237	143	57	142	103	100	16	9	10	8	0	0.857	1.000	1.000
284	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH1A(10), ADH1B(17), ADH1C(22), ADH4(7), ADH6(7), ADH7(12), ADHFE1(3), DHRS1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(3), MYST3(10), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(2)	5036341	119	57	111	52	86	10	5	14	4	0	0.213	1.000	1.000
285	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(5), AADAC(10), ABAT(6), ACADS(2), ACAT2(1), ACSM1(12), AKR1B10(5), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH5A1(7), ALDH7A1(3), ALDH9A1(2), BDH1(4), DDHD1(5), EHHADH(5), GAD1(7), GAD2(4), HADHA(7), HMGCL(2), HMGCS1(1), HMGCS2(14), HSD17B10(1), HSD17B4(3), HSD3B7(1), ILVBL(2), L2HGDH(2), OXCT1(3), OXCT2(2), PDHA1(1), PDHA2(9), PDHB(1), PLA1A(4), PPME1(1), PRDX6(2), RDH12(1), RDH13(3)	8154067	150	57	148	80	106	12	8	11	13	0	0.262	1.000	1.000
286	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(3), BLVRA(1), BLVRB(1), CP(10), CPOX(2), EPRS(6), FECH(2), GUSB(3), HCCS(2), HMBS(1), HMOX1(1), PPOX(2), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2B15(18), UGT2B4(23), UROS(1)	5548676	126	57	121	61	84	12	5	7	18	0	0.207	1.000	1.000
287	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(5), EIF2B1(6), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), FLT1(21), FLT4(19), HIF1A(1), HRAS(1), KDR(25), NOS3(13), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(8), PTK2(3), PXN(3), SHC1(1), VHL(2)	6842995	123	57	113	63	85	10	1	13	14	0	0.349	1.000	1.000
288	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(3), AGTR1(7), ATF2(5), CALM2(1), EGFR(16), ELK1(1), GNAQ(1), GRB2(2), HRAS(1), JUN(1), MAP2K1(7), MAP2K2(2), MAP2K4(3), MAPK1(3), MAPK3(1), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), PAK1(2), PRKCA(8), PTK2(3), PTK2B(7), RAC1(9), RAF1(2), SHC1(1), SOS1(6), SRC(1), SYT1(12)	6690956	113	56	105	68	82	9	4	12	6	0	0.817	1.000	1.000
289	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(1), EIF4A1(3), EIF4A2(3), EIF4G1(8), EIF4G2(3), EIF4G3(11), GHR(16), IRS1(3), MAPK1(3), MAPK14(4), MAPK3(1), MKNK1(5), PABPC1(4), PDK2(4), PDPK1(3), PIK3CA(2), PIK3R1(2), PRKCA(8), PTEN(12), RPS6KB1(2)	5676879	98	56	96	32	51	12	7	10	18	0	0.0713	1.000	1.000
290	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(5), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), CYP2C19(29), CYP2C9(28), DHRS1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(3), EHHADH(5), HADHA(7), MYST3(10), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(2)	6230641	130	56	124	86	95	11	5	10	9	0	0.894	1.000	1.000
291	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(3), CAPN1(1), CAPN2(2), CAPNS1(1), CXCR3(2), EGF(14), EGFR(16), HRAS(1), ITGA1(15), ITGB1(4), MAPK1(3), MAPK3(1), MYL2(4), MYLK(22), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PTK2(3), PXN(3), TLN1(10)	6496874	122	56	119	73	93	5	4	12	8	0	0.481	1.000	1.000
292	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(3), ANXA2(1), ANXA3(3), ANXA4(1), ANXA5(1), ANXA6(3), CYP11A1(9), EDN1(7), EDNRA(4), EDNRB(4), HSD11B1(8), PLA2G4A(8), PRL(1), PTGDR(7), PTGDS(2), PTGER2(5), PTGFR(13), PTGIR(3), PTGIS(9), PTGS1(14), PTGS2(6), TBXAS1(8)	4092694	120	56	115	53	91	11	3	7	8	0	0.00929	1.000	1.000
293	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5(3), CFL1(1), CHN1(3), LIMK1(4), MYL2(4), MYLK(22), NCF2(5), PAK1(2), PDGFRA(15), PIK3CA(2), PIK3R1(2), PLD1(7), PPP1R12B(5), RAC1(9), RALBP1(2), RPS6KB1(2), TRIO(10), VAV1(13), WASF1(1)	7017477	113	56	106	68	81	5	6	12	9	0	0.808	1.000	1.000
294	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ARHGAP1(1), ARHGAP4(1), ARHGAP5(9), ARHGAP6(5), ARHGEF1(1), ARHGEF11(10), ARHGEF5(12), ARPC1B(2), ARPC2(1), ARPC3(1), BAIAP2(3), CFL1(1), DIAPH1(6), GSN(5), LIMK1(4), MYL2(4), MYLK(22), OPHN1(4), PIP5K1A(6), PIP5K1B(15), PPP1R12B(5), ROCK1(3), SRC(1), TLN1(10), VCL(4)	9009225	138	56	136	67	100	9	5	16	8	0	0.117	1.000	1.000
295	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(4), CHUK(1), ELK1(1), FOS(1), IKBKB(2), JUN(1), LY96(3), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP3K14(1), MAPK14(4), MYD88(2), NFKB1(3), NFKBIA(2), PPARA(4), RELA(2), TLR10(9), TLR2(10), TLR3(7), TLR4(26), TLR6(3), TLR7(6), TLR9(8), TOLLIP(1), TRAF6(2)	7258829	112	56	110	68	76	11	3	15	7	0	0.739	1.000	1.000
296	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(1), APC(12), AXIN1(6), CCND1(1), CD14(4), CTNNB1(6), FZD1(1), GJA1(6), GNAI1(1), GSK3B(2), LBP(6), LEF1(1), LY96(3), MYD88(2), NFKB1(3), PDPK1(3), PIK3CA(2), PIK3R1(2), PPP2CA(1), RELA(2), TLR4(26), TOLLIP(1), WNT1(1)	6077365	93	55	89	58	62	8	4	10	9	0	0.913	1.000	1.000
297	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(3), EXTL1(1), EXTL3(5), GLCE(7), HS2ST1(1), HS3ST1(8), HS3ST2(6), HS3ST3B1(2), HS3ST5(5), HS6ST1(3), HS6ST2(1), HS6ST3(9), NDST1(3), NDST3(14), NDST4(32)	4072715	101	55	99	53	66	7	4	11	13	0	0.243	1.000	1.000
298	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(3), ACTN1(2), ACTN2(14), ACTN3(5), BCAR1(3), BCR(6), CAPN1(1), CAPNS1(1), CAV1(1), CSK(1), FYN(5), GRB2(2), HRAS(1), ITGA1(15), ITGB1(4), JUN(1), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), PPP1R12B(5), PTK2(3), PXN(3), RAF1(2), RAP1A(1), ROCK1(3), SHC1(1), SOS1(6), SRC(1), TLN1(10), VCL(4), ZYX(4)	9337019	121	55	117	66	77	12	4	18	9	1	0.417	1.000	1.000
299	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(6), EGF(14), EGFR(16), GRB2(2), HRAS(1), MAP2K1(7), MAPK1(3), MAPK3(1), PTPRB(59), RAF1(2), RASA1(1), SHC1(1), SOS1(6), SPRY1(6), SPRY2(3), SPRY3(7), SPRY4(1), SRC(1)	5001420	137	55	126	62	106	10	3	11	7	0	0.261	1.000	1.000
300	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), AKT2(6), AKT3(3), CISH(2), GRB2(2), IARS(5), IL13RA1(3), IL2RG(2), IL4(1), IL4R(7), INPP5D(22), JAK1(4), JAK2(6), JAK3(5), NR0B2(6), PI3(6), PIK3CA(2), PPP1R13B(5), RPS6KB1(2), SERPINA4(10), SHC1(1), SOS1(6), SOS2(3), SRC(1), STAT6(5), TYK2(4)	7371587	120	55	119	57	84	9	6	11	10	0	0.310	1.000	1.000
301	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(3), BAX(1), BCL2(2), CASP1(3), CASP10(4), CASP2(1), CASP3(1), CASP4(1), CASP7(4), CASP8(2), CASP9(3), CD40(1), CD40LG(2), CRADD(1), CYCS(1), DAXX(5), DFFA(1), DFFB(2), FAS(3), FASLG(10), IKBKE(7), LTA(2), MCL1(2), NFKB1(3), NFKBIA(2), NGFR(6), NR3C1(2), NTRK1(10), PTPN13(8), RIPK1(1), SFRS2IP(5), TFG(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF1(6), TRAF2(2), TRAF3(3), TRAF6(2)	8684604	118	54	117	67	80	9	6	9	14	0	0.648	1.000	1.000
302	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(12), CD2(20), CD33(12), CD5(3), CSF2(2), IFNB1(5), IFNG(2), IL10(2), IL12A(2), IL12B(3), IL13(2), IL3(2), IL4(1), IL5(4), ITGAX(14), TLR2(10), TLR4(26), TLR7(6), TLR9(8)	3717732	136	54	130	65	100	11	2	9	14	0	0.00135	1.000	1.000
303	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(16), ELK1(1), GNAS(12), GRB2(2), HRAS(1), IGF1R(6), ITGB1(4), KLK2(1), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), MKNK1(5), MKNK2(2), MYC(2), NGFR(6), PDGFRA(15), PPP2CA(1), PTPRR(19), RAF1(2), RPS6KA1(4), RPS6KA5(4), SHC1(1), SOS1(6), SRC(1), STAT3(6)	6577341	130	54	125	67	90	10	7	17	6	0	0.370	1.000	1.000
304	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(11), ALDH1A3(2), ALDH3A1(4), ALDH3B1(2), ALDH3B2(5), AOC2(5), AOC3(6), DDC(7), EPX(5), GOT1(4), GOT2(2), HPD(3), LPO(11), MAOA(2), MAOB(7), MPO(6), MYST3(10), MYST4(11), NAT6(2), PNPLA3(1), PRDX6(2), SH3GLB1(2), TAT(12), TPO(30)	6877546	152	54	148	106	120	13	7	7	5	0	0.846	1.000	1.000
305	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10B(3), ALG12(1), ALG13(4), ALG2(3), ALG3(1), ALG5(1), ALG6(2), ALG8(3), ALG9(5), B4GALT1(1), B4GALT2(2), B4GALT3(2), DDOST(2), DOLPP1(3), DPAGT1(2), DPM1(1), FUT8(5), GANAB(5), MAN1A1(8), MAN1A2(3), MAN1B1(2), MAN1C1(6), MAN2A1(8), MGAT1(1), MGAT3(9), MGAT4A(5), MGAT5(2), MGAT5B(8), RFT1(1), RPN2(2), ST6GAL1(4), STT3B(3)	8480864	110	54	108	65	68	13	4	12	13	0	0.590	1.000	1.000
306	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(6), ACACA(16), ACACB(14), ACADM(5), ACAT2(1), ACSS2(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH6A1(2), ALDH7A1(3), ALDH9A1(2), EHHADH(5), HADHA(7), HIBCH(1), LDHA(2), LDHAL6A(1), LDHAL6B(6), LDHC(3), MCEE(1), MLYCD(2), MUT(4), PCCA(2), PCCB(1), SUCLG1(1), SUCLG2(2)	8000748	102	54	100	53	63	8	8	15	8	0	0.454	1.000	1.000
307	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(4), HLA-A(2), IL18(2), ITGB1(4), KLRC1(2), KLRC2(1), KLRC3(5), KLRC4(4), KLRD1(4), MAP2K1(7), MAPK3(1), PAK1(2), PIK3CA(2), PIK3R1(2), PTK2B(7), PTPN6(1), RAC1(9), SYK(11), VAV1(13)	3718696	83	54	74	41	62	4	2	8	7	0	0.430	1.000	1.000
308	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(6), ACACA(16), ACADL(2), ACADM(5), ACADSB(3), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH6A1(2), ALDH9A1(2), EHHADH(5), HADHA(7), LDHA(2), LDHC(3), MCEE(1), MLYCD(2), MUT(4), PCCA(2), PCCB(1), SUCLG1(1), SUCLG2(2)	6676922	91	54	90	43	59	7	7	13	5	0	0.396	1.000	1.000
309	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(8), DLG4(4), EPHB2(17), F2(6), F2RL1(10), F2RL2(4), JUN(1), MAP2K5(2), MAPK1(3), MAPK7(2), PLD1(7), PLD2(3), PLD3(1), PTK2(3), RAF1(2), RASAL1(10), SRC(1), TEC(7), VAV1(13)	5485370	104	54	101	72	70	8	4	15	7	0	0.898	1.000	1.000
310	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(4), AKT1(1), AKT2(6), AKT3(3), DAG1(3), GNAQ(1), ITPKB(5), ITPR1(19), ITPR2(10), ITPR3(4), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PDK1(1), PHKA2(6), PIK3CB(10), PITX2(1), PLD1(7), PLD2(3), PLD3(1)	8973114	97	54	95	68	52	11	7	15	12	0	0.878	1.000	1.000
311	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(1), BCL2(2), EGFR(16), IGF1R(6), MYC(2), POLR2A(10), PPP2CA(1), PRKCA(8), RB1(3), TEP1(20), TERT(4), TNKS(5), TP53(26)	5641661	104	54	100	57	62	9	7	11	13	2	0.559	1.000	1.000
312	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(12), ATF2(5), AXIN1(6), BMP10(8), BMP2(4), BMP4(2), BMP5(12), BMP7(2), BMPR1A(1), BMPR2(4), CHRD(8), CTNNB1(6), FZD1(1), GATA4(2), GSK3B(2), MEF2C(2), MYL2(4), NOG(1), NPPA(1), NPPB(4), RFC1(2), TGFB2(1), TGFB3(1), TGFBR2(5), TGFBR3(5), WNT1(1)	7238046	103	53	99	60	74	9	5	5	10	0	0.843	1.000	1.000
313	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CARM1(4), CCND1(1), CREBBP(14), EP300(8), ERCC3(3), ESR1(2), GRIP1(4), GTF2A1(2), GTF2F1(2), HDAC1(1), HDAC3(3), HDAC4(8), HDAC5(3), HDAC6(2), MEF2C(2), NCOR2(15), NR0B1(2), NRIP1(5), PELP1(9), POLR2A(10), TBP(4)	9084997	110	53	109	53	79	5	8	10	8	0	0.381	1.000	1.000
314	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), GALNS(2), GBA(2), GLB1(5), GUSB(3), HEXA(5), HEXB(2), HGSNAT(4), HPSE(6), HPSE2(3), HYAL2(1), IDS(5), IDUA(4), LCT(31), MAN2B1(6), MAN2B2(4), MAN2C1(1), MANBA(4), NAGLU(3), NEU1(4), NEU2(12), NEU3(2), NEU4(7), SPAM1(14)	6833119	133	53	132	75	99	10	3	13	8	0	0.434	1.000	1.000
315	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(5), DAXX(5), DDIT3(1), ELK1(1), GRB2(2), HMGN1(1), HRAS(1), HSPB1(2), HSPB2(1), MAP2K4(3), MAP2K6(2), MAP3K5(11), MAP3K9(17), MAPK14(4), MAPKAPK2(2), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), MKNK1(5), MYC(2), PLA2G4A(8), RAC1(9), RIPK1(1), RPS6KA5(4), SHC1(1), STAT1(2), TGFB2(1), TGFB3(1), TRAF2(2)	7272185	102	53	98	39	70	10	3	11	8	0	0.106	1.000	1.000
316	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), ERCC3(3), GTF2A2(1), GTF2B(1), GTF2E2(4), GTF2F2(2), GTF2H1(3), GTF2H4(1), MNAT1(2), POLR1A(7), POLR1B(5), POLR2A(10), POLR2B(11), POLR2E(1), POLR2F(1), POLR2H(2), POLR2J(1), POLR3B(12), POLR3D(1), POLR3E(2), POLR3K(1), TAF6(2), TAF7(1), TAF9(1), TBP(4)	7062863	80	53	79	28	51	9	6	11	3	0	0.0578	1.000	1.000
317	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), ATF1(3), CREB5(7), DUSP10(6), EEF2K(2), ELK1(1), HSPB1(2), IL1R1(7), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP3K10(5), MAP3K4(11), MAP3K5(11), MAPK1(3), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPKAPK2(2), MKNK1(5), MKNK2(2), NFKB1(3), NR2C2(2), SRF(1), TRAF6(2)	6662487	95	53	94	53	65	8	3	12	7	0	0.623	1.000	1.000
318	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(8), EEF1B2(1), EEF1G(1), EEF2(2), EEF2K(2), EIF1AX(2), EIF2AK1(2), EIF2AK2(2), EIF2AK3(7), EIF2B1(6), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), EIF4A1(3), EIF4A2(3), EIF4G1(8), EIF4G3(11), ETF1(1), GSPT2(2), KIAA0664(3), PABPC1(4), PABPC3(8), PAIP1(7), SLC35A4(3)	8755287	93	53	88	48	53	7	5	12	16	0	0.727	1.000	1.000
319	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(3), CR1(35), CR2(20), FCGR2B(1), HLA-DRA(7), HLA-DRB1(2), ICAM1(2), ITGAL(17), ITGB2(10), PTPRC(18)	3007705	115	52	108	47	86	6	1	12	10	0	0.0991	1.000	1.000
320	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(3), UCHL1(4), UCHL3(2), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6), UGT2B15(18), UGT2B4(23)	3557943	102	52	94	52	71	9	5	4	13	0	0.202	1.000	1.000
321	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(11), ALDH1A3(2), ALDH3A1(4), ALDH3B1(2), ALDH3B2(5), AOC2(5), AOC3(6), DDC(7), EPX(5), GOT1(4), GOT2(2), HPD(3), LPO(11), MAOA(2), MAOB(7), MPO(6), PRDX1(1), PRDX2(2), PRDX6(2), TAT(12), TPO(30)	4392207	129	52	126	85	104	10	6	5	4	0	0.311	1.000	1.000
322	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(4), ABAT(6), ADSL(6), ADSS(1), AGXT(8), AGXT2(13), ASL(3), ASNS(7), ASPA(3), CAD(12), CRAT(4), DARS(2), DDO(4), GAD1(7), GAD2(4), GOT1(4), GOT2(2), GPT(3), NARS(2), PC(6)	5252387	101	51	98	56	70	11	7	10	3	0	0.263	1.000	1.000
323	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(9), DIAPH1(6), FYN(5), GSN(5), HRAS(1), ITGA1(15), ITGB1(4), MAP2K1(7), MAPK1(3), MAPK3(1), MYL2(4), MYLK(22), PIK3CA(2), PIK3R1(2), PTK2(3), PXN(3), RAF1(2), ROCK1(3), SHC1(1), SRC(1), TLN1(10)	7479374	109	51	103	52	78	9	3	15	4	0	0.261	1.000	1.000
324	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), GHR(16), GRB2(2), HRAS(1), INSR(13), IRS1(3), JAK2(6), MAP2K1(7), MAPK1(3), MAPK3(1), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(8), PTPN6(1), RAF1(2), RPS6KA1(4), SHC1(1), SLC2A4(6), SOS1(6), SRF(1), STAT5A(2), STAT5B(4)	6651337	96	51	92	51	63	9	4	15	5	0	0.466	1.000	1.000
325	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(23), ACE2(5), AGT(3), AGTR1(7), AGTR2(3), ANPEP(12), CMA1(4), CPA3(12), CTSA(3), CTSG(4), ENPEP(19), LNPEP(9), MAS1(2), MME(12), NLN(2), REN(8), THOP1(4)	4213120	132	51	128	71	97	13	5	6	11	0	0.144	1.000	1.000
326	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(22), ATP4B(1), ATP5O(3), ATP6AP1(1), ATP6V0A1(5), ATP6V0A4(12), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C2(6), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), ATP7A(1), ATP7B(14), COX10(4), COX5B(1), COX6B1(1), COX7B(1), COX8A(1), NDUFA10(1), NDUFB2(1), NDUFB5(1), NDUFB6(2), NDUFS2(1), NDUFV1(1), PPA2(2), SDHA(1), UQCRC1(3), UQCRFS1(2)	7707115	107	51	107	76	69	7	10	11	10	0	0.935	1.000	1.000
327	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM2(1), GNAQ(1), GRB2(2), HRAS(1), JUN(1), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K4(3), MAPK1(3), MAPK14(4), MAPK3(1), PAK1(2), PLCG1(4), PRKCA(8), PTK2B(7), RAC1(9), RAF1(2), SHC1(1), SOS1(6), SRC(1), SYT1(12)	5696004	85	51	77	50	61	7	3	10	4	0	0.699	1.000	1.000
328	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(17), AKT1(1), BAX(1), BCL2(2), CSF2RB(14), IGF1(7), IGF1R(6), IL3(2), IL3RA(4), KIT(7), KITLG(6), PIK3CA(2), PIK3R1(2), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4)	4382716	88	50	88	54	61	7	3	7	10	0	0.565	1.000	1.000
329	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(16), FOS(1), HRAS(1), JUN(1), MAP2K1(7), MAPK1(3), MAPK3(1), MYC(2), NFKB1(3), NFKBIA(2), PLCB1(33), PRKCA(8), RAF1(2), RELA(2), TNF(1)	3127462	83	50	75	35	62	6	4	6	5	0	0.0477	1.000	1.000
330	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(5), AZIN1(1), BTG1(2), CLOCK(2), CRY1(3), CRY2(2), EIF4G2(3), ETV6(8), GFRA1(6), GSTM3(2), HERPUD1(2), HSPA8(4), KLF9(2), MYF6(7), NCKAP1(2), NCOA4(1), NR1D2(5), PER1(4), PER2(10), PIGF(2), PPP1R3C(2), PPP2CB(2), PURA(1), SF3A3(2), TOB1(2), TUBB3(3), UCP3(3), UGP2(1), ZFR(3)	7321232	92	50	92	48	50	10	6	18	8	0	0.841	1.000	1.000
331	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(3), CRK(2), CXCL12(1), CXCR4(1), GNAI1(1), GNAQ(1), HRAS(1), MAP2K1(7), MAPK1(3), MAPK3(1), NFKB1(3), PIK3C2G(32), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(8), PTK2(3), PTK2B(7), PXN(3), RAF1(2), RELA(2)	5503459	89	50	83	49	68	4	0	10	7	0	0.545	1.000	1.000
332	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(12), CALCR(13), CALCRL(8), CD97(5), CRHR1(2), CRHR2(1), ELTD1(17), EMR1(17), EMR2(1), GHRHR(4), GIPR(2), GLP1R(5), GLP2R(7), GPR64(1), LPHN1(4), LPHN2(24), LPHN3(10), SCTR(5), VIPR1(3), VIPR2(4)	5263678	145	50	135	112	110	9	5	7	14	0	0.798	1.000	1.000
333	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(11), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(5), ALDH9A1(2), AOC2(5), AOC3(6), ASPA(3), CNDP1(7), DDC(7), HAL(8), HARS(3), HDC(8), MAOA(2), MAOB(7), PRPS1(1), PRPS2(1)	4869720	102	50	102	73	74	11	6	6	5	0	0.762	1.000	1.000
334	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(6), ADC(3), ALDH4A1(5), ALDH5A1(7), CAD(12), CPS1(13), EPRS(6), GAD1(7), GAD2(4), GCLC(4), GCLM(1), GFPT1(1), GFPT2(4), GLS(1), GLS2(3), GLUD1(1), GLUD2(1), GMPS(3), GOT1(4), GOT2(2), GPT(3), GSR(2), GSS(5), NADSYN1(2), QARS(6)	7926697	106	50	103	70	62	13	8	16	7	0	0.862	1.000	1.000
335	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(8), ABCC2(7), ABCG2(6), BCHE(6), CES1(12), CES2(3), CYP3A4(13), CYP3A5(4), UGT1A1(1), UGT1A10(13), UGT1A3(7), UGT1A4(2), UGT1A5(7), UGT1A6(2), UGT1A7(9), UGT1A8(3), UGT1A9(6)	4600376	109	50	104	49	75	8	6	9	11	0	0.0228	1.000	1.000
336	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(12), AXIN1(6), CREBBP(14), CTNNB1(6), EP300(8), FZD1(1), GSK3B(2), HDAC1(1), LDB1(1), LEF1(1), PITX2(1), TRRAP(29), WNT1(1)	6673218	83	50	81	52	46	8	7	11	11	0	0.955	1.000	1.000
337	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(20), F2(6), F2R(4), FGA(20), FGB(7), FGG(4), PLAT(2), PLAU(2), PLG(20), SERPINB2(8), SERPINE1(2)	2675723	95	49	93	40	76	6	3	5	5	0	0.145	1.000	1.000
338	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(17), CALM2(1), ELK1(1), FOS(1), GNAI1(1), GNAQ(1), GNAS(12), HRAS(1), JUN(1), MAP2K1(7), MAPK3(1), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), RAF1(2), SYT1(12)	6953437	123	49	119	78	91	9	4	10	9	0	0.852	1.000	1.000
339	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(3), CALM2(1), CAMK1(4), CAMK1G(9), HDAC5(3), IGF1(7), IGF1R(6), INSR(13), MAP2K6(2), MAPK14(4), MAPK7(2), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), NFATC1(13), NFATC2(6), PIK3CA(2), PIK3R1(2), PPP3CA(4), PPP3CB(1), PPP3CC(1), SYT1(12)	6985715	104	49	104	64	75	9	3	13	4	0	0.690	1.000	1.000
340	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNB1(5), IKBKB(2), IL1A(3), IL1B(5), IL1R1(7), IL1RAP(3), IL1RN(6), IRAK2(10), IRAK3(7), JUN(1), MAP2K3(4), MAP2K6(2), MAP3K14(1), MAPK14(4), MYD88(2), NFKB1(3), NFKBIA(2), RELA(2), TGFB2(1), TGFB3(1), TNF(1), TOLLIP(1), TRAF6(2)	5905110	76	49	74	46	49	8	1	8	10	0	0.700	1.000	1.000
341	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(17), ARHGEF1(1), F2(6), F2R(4), GNA12(2), GNA13(1), GNAI1(1), GNAQ(1), PIK3CA(2), PIK3R1(2), PLCB1(33), PPP1R12B(5), PRKCA(8), PTK2B(7), ROCK1(3)	5179297	93	49	89	49	71	6	2	8	6	0	0.374	1.000	1.000
342	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(2), ESR2(5), PDE1A(22), PDE1B(8), PLCB1(33), PLCB2(7), PRL(1), TRH(3), VIP(3)	2202188	84	49	76	43	70	2	1	5	6	0	0.169	1.000	1.000
343	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), DAG1(3), ITPKB(5), ITPR1(19), ITPR2(10), ITPR3(4), NFAT5(3), PDE6A(9), PDE6B(11), PDE6C(18), PDE6D(2), PDE6G(2), SLC6A13(14), TF(5)	7140232	117	49	113	68	84	8	3	9	13	0	0.267	1.000	1.000
344	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(5), ABAT(6), ACADS(2), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH5A1(7), ALDH9A1(2), EHHADH(5), GAD1(7), GAD2(4), HADHA(7), HMGCL(2), L2HGDH(2), OXCT1(3), PDHA1(1), PDHA2(9), PDHB(1)	5206475	88	48	87	41	58	8	2	10	10	0	0.133	1.000	1.000
345	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CSNK1D(1), DRD1(8), DRD2(9), GRM1(9), PLCB1(33), PPP1CA(1), PPP1R1B(1), PPP2CA(1), PPP3CA(4), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4)	3192471	87	48	84	57	69	0	3	8	7	0	0.658	1.000	1.000
346	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(17), AKT1(1), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), GNAS(12), GRB2(2), HRAS(1), MAPK1(3), MAPK14(4), MAPK3(1), PIK3CA(2), PIK3R1(2), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8), RAC1(9), RPS6KA1(4), RPS6KA5(4), SOS1(6)	5784333	105	48	100	61	77	5	4	10	9	0	0.729	1.000	1.000
347	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), CDT1(1), DIAPH2(4), MCM10(6), MCM2(8), MCM3(7), MCM4(3), MCM5(2), MCM6(3), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(2), ORC5L(1), ORC6L(2), PCNA(1), POLA2(6), POLD1(3), POLD2(2), POLD3(3), POLE(10), POLE2(1), PRIM1(1), RFC1(2), RFC3(1), RPA1(3), RPA2(1), RPA4(2), UBC(4)	10161802	86	48	86	46	56	5	4	11	10	0	0.477	1.000	1.000
348	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(3), ACP2(2), ACP5(3), ACP6(8), ACPP(6), ALPI(3), ALPL(6), ALPP(6), ALPPL2(7), CMBL(1), CYP3A4(13), CYP3A43(10), CYP3A5(4), CYP3A7(14), DHRS1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(3), PON1(12), PON2(1), PON3(4)	3598721	116	48	112	40	85	7	6	8	10	0	0.000510	1.000	1.000
349	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(8), ALDOC(1), FBP1(1), FBP2(1), GOT1(4), GOT2(2), GPT(3), MDH1(1), MDH2(2), ME1(14), ME3(6), PGK1(2), PGK2(17), PKLR(6), PKM2(5), TKT(5), TKTL1(1), TKTL2(14)	4069059	94	48	91	54	72	7	4	5	6	0	0.144	1.000	1.000
350	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT10(4), GALNT2(4), GALNT3(2), GALNT4(2), GALNT6(13), GALNT7(5), GALNT8(14), GALNT9(3), GCNT1(4), ST3GAL1(5), ST3GAL4(1), WBSCR17(24)	2907672	83	48	80	39	62	5	1	7	8	0	0.169	1.000	1.000
351	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BCL2(2), BIRC2(4), BIRC3(6), CASP10(4), CASP3(1), CASP7(4), CASP8(2), CASP9(3), CFLAR(3), CHUK(1), CYCS(1), DFFA(1), DFFB(2), GAS2(5), LMNA(3), MAP3K14(1), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), SPTAN1(4), TNFRSF10A(4), TNFRSF10B(1), TNFRSF25(4), TNFSF10(5), TNFSF12(1), TRAF2(2)	6706859	75	47	75	50	49	8	8	7	3	0	0.852	1.000	1.000
352	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(6), ACO1(2), ACO2(2), CLYBL(2), CS(1), DLD(1), FH(3), IDH1(7), IDH3A(3), IDH3G(2), MDH1(1), MDH2(2), OGDH(8), OGDHL(22), PC(6), PCK1(20), PCK2(3), SDHA(1), SDHC(2), SUCLG1(1), SUCLG2(2)	6026956	97	47	90	49	73	3	6	8	7	0	0.185	1.000	1.000
353	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(6), POLD1(3), POLD2(2), POLD3(3), POLE(10), POLE2(1), POLG(4), POLG2(4), POLH(3), POLI(1), POLK(4), POLL(7), POLM(2), POLQ(15), PRIM1(1), PRIM2(8), REV1(3), REV3L(8)	8123168	86	47	85	31	48	5	5	16	12	0	0.153	1.000	1.000
354	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(1), BCL2(2), CBL(6), CFLAR(3), E2F1(5), FOS(1), GRB2(2), HRAS(1), IL2RA(4), IL2RB(7), IL2RG(2), IRS1(3), JAK1(4), JAK3(5), MAPK1(3), MAPK3(1), MYC(2), PIK3CA(2), PIK3R1(2), PPIA(1), PTPN6(1), RAF1(2), RPS6KB1(2), SHC1(1), SOCS3(2), SOS1(6), STAT5A(2), STAT5B(4), SYK(11)	7207496	88	47	87	50	56	8	10	8	6	0	0.698	1.000	1.000
355	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(1), EIF4A1(3), EIF4A2(3), EIF4B(1), EIF4G1(8), EIF4G2(3), EIF4G3(11), FKBP1A(2), MKNK1(5), PDK2(4), PDPK1(3), PIK3CA(2), PIK3R1(2), PPP2CA(1), PTEN(12), RPS6(1), RPS6KB1(2), TSC1(3), TSC2(7)	5551204	74	47	73	28	35	8	7	9	15	0	0.271	1.000	1.000
356	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(12), CAMP(1), CASP3(1), CREB5(7), DAG1(3), EPHB2(17), FOS(1), GNAQ(1), ITPKB(5), JUN(1), MAP2K4(3), MAP2K7(2), MAPK1(3), MAPK10(6), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(6), MAPK9(1)	5694642	77	47	77	50	53	5	4	8	7	0	0.882	1.000	1.000
357	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(17), CD3D(5), CD3E(2), CD4(4), CREBBP(14), CSK(1), GNAS(12), HLA-DRA(7), HLA-DRB1(2), LCK(9), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PTPRC(18), ZAP70(4)	4532775	112	46	109	66	82	8	4	9	9	0	0.638	1.000	1.000
358	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(17), CD3D(5), CD3E(2), CD4(4), CREBBP(14), CSK(1), GNAS(12), HLA-DRA(7), HLA-DRB1(2), LCK(9), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PTPRC(18), ZAP70(4)	4532775	112	46	109	66	82	8	4	9	9	0	0.638	1.000	1.000
359	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSD(2), ARSE(4), GAL3ST1(7), GALC(1), GBA(2), GLA(1), GLB1(5), LCT(31), NEU1(4), NEU2(12), NEU3(2), NEU4(7), PPAP2B(4), PPAP2C(6), SMPD1(1), SPTLC2(5), UGCG(1)	4795831	95	46	93	64	74	9	2	7	3	0	0.808	1.000	1.000
360	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(11), ADC(3), AGMAT(3), ALDH18A1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), AOC2(5), AOC3(6), ARG1(1), ARG2(1), ASL(3), ASS1(3), CPS1(13), GATM(2), MAOA(2), MAOB(7), ODC1(2), OTC(2), SMS(1)	5839708	85	46	84	59	56	9	7	4	9	0	0.747	1.000	1.000
361	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(16), PGAP1(2), PIGB(3), PIGC(1), PIGF(2), PIGG(9), PIGK(4), PIGL(2), PIGN(2), PIGO(9), PIGQ(6), PIGS(1), PIGT(1), PIGU(4), PIGV(7), PIGW(1), PIGX(1), PIGZ(1)	4798954	72	46	70	31	47	5	5	10	5	0	0.0866	1.000	1.000
362	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(5), CCR2(8), CCR3(8), CCR4(5), CCR5(5), CCR7(3), CD4(4), CSF2(2), CXCR3(2), CXCR4(1), IFNG(2), IFNGR1(3), IFNGR2(2), IL12A(2), IL12B(3), IL12RB1(9), IL12RB2(3), IL18R1(14), IL2(4), IL4(1), IL4R(7), IL5(4), TGFB2(1), TGFB3(1)	4005065	99	46	97	57	74	10	0	6	9	0	0.135	1.000	1.000
363	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(26), AKT1(1), ATM(10), BAX(1), CDKN1A(2), CSNK1A1(2), CSNK1D(1), HIC1(1), HIF1A(1), IGFBP3(1), MDM2(2), NFKBIB(1), NQO1(1), TP53(26)	4177354	76	46	69	33	45	7	2	8	14	0	0.414	1.000	1.000
364	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(3), MAP2K7(2), MAPK1(3), MAPK10(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(4), MAPK3(1), MAPK8IP1(4), MAPK8IP2(3), MAPK8IP3(6), MAPK9(1), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PIK3CA(2), PIK3CD(2), PIK3R1(2), SYT1(12), TRAF2(2), TRAF3(3), TRAF5(5), TRAF6(2)	6687999	81	46	81	61	54	7	5	11	4	0	0.909	1.000	1.000
365	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(3), ATM(10), BRCA1(6), CDKN1A(2), CHEK1(1), JUN(1), MDM2(2), MRE11A(3), NFKB1(3), NFKBIA(2), RAD50(3), RBBP8(3), RELA(2), TP53(26), TP73(4)	5955600	71	45	67	31	40	6	4	8	13	0	0.572	1.000	1.000
366	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), AKR1D1(14), CYP11A1(9), CYP11B1(8), CYP11B2(9), CYP17A1(5), CYP21A2(12), HSD11B1(8), HSD3B1(4), HSD3B2(9)	1967878	82	45	77	41	57	7	3	8	7	0	0.0251	1.000	1.000
367	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(14), EGFR(16), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(4), JUN(1), MAP2K1(7), MAP2K4(3), MAPK3(1), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(8), RAF1(2), RASA1(1), SHC1(1), SOS1(6), SRF(1), STAT1(2), STAT3(6), STAT5A(2)	7495909	89	45	85	54	59	8	4	11	7	0	0.896	1.000	1.000
368	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(8), CSF1R(9), DDX20(7), E2F1(5), ETS1(3), ETS2(8), ETV3(3), FOS(1), HDAC5(3), HRAS(1), JUN(1), NCOR2(15), RBL1(5), RBL2(2), SIN3A(5), SIN3B(7)	5207449	83	45	83	55	57	6	0	13	7	0	0.848	1.000	1.000
369	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(2), CASP10(4), CASP3(1), CASP7(4), CASP8(2), CFLAR(3), DAXX(5), DFFA(1), DFFB(2), FAF1(3), JUN(1), LMNA(3), LMNB1(1), LMNB2(4), MAP2K4(3), PAK1(2), PAK2(2), PRKDC(13), PTPN13(8), RB1(3), RIPK2(1), SPTAN1(4)	8238204	72	45	72	39	38	7	9	13	3	2	0.768	1.000	1.000
370	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(6), ALDH4A1(5), ALDH5A1(7), CAD(12), CPS1(13), EPRS(6), GAD1(7), GAD2(4), GCLC(4), GCLM(1), GFPT1(1), GLS(1), GLS2(3), GLUD1(1), GMPS(3), GOT1(4), GOT2(2), GPT(3), GSS(5), NADSYN1(2), QARS(6)	6664465	96	45	93	55	56	12	8	14	6	0	0.653	1.000	1.000
371	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(5), ALDOA(1), ALDOB(8), ALDOC(1), FBP1(1), FBP2(1), FPGT(2), FUK(1), GMDS(4), GMPPA(1), GMPPB(2), HK1(1), HK2(5), HK3(10), HSD3B7(1), KHK(1), LHPP(1), MPI(1), MTMR1(3), MTMR2(1), MTMR6(2), PFKFB1(2), PFKFB2(3), PFKFB3(2), PFKFB4(4), PFKL(2), PGM2(5), RDH12(1), RDH13(3), SORD(1), TSTA3(2)	7392840	80	45	77	56	57	10	4	4	5	0	0.559	1.000	1.000
372	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), AKR1D1(14), CYP11A1(9), CYP11B1(8), CYP11B2(9), CYP17A1(5), CYP21A2(12), HSD11B1(8), HSD3B1(4), HSD3B2(9)	1967878	82	45	77	41	57	7	3	8	7	0	0.0251	1.000	1.000
373	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(4), CARM1(4), CBS(5), GGT1(4), HEMK1(1), LCMT1(4), MARS(5), MARS2(3), MAT1A(4), MAT2B(1), METTL2B(6), PAPSS1(2), PAPSS2(4), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), SCLY(2), SEPHS1(4), SEPHS2(1), WBSCR22(1)	5036454	75	45	74	28	45	7	4	12	7	0	0.0421	1.000	1.000
374	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2A1L(3), GTF2A2(1), GTF2B(1), GTF2E2(4), GTF2F1(2), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(1), GTF2I(2), GTF2IRD1(4), TAF1(6), TAF1L(36), TAF2(2), TAF4(6), TAF5L(3), TAF6(2), TAF6L(3), TAF7(1), TAF7L(4), TAF9(1), TBPL1(1), TBPL2(2)	7282184	93	45	92	42	62	10	4	12	5	0	0.449	1.000	1.000
375	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(8), ANAPC10(1), ANAPC2(3), ANAPC4(1), ANAPC5(4), ANAPC7(4), BTRC(4), CDC16(1), CDC27(6), CUL1(4), CUL2(2), CUL3(3), FBXW11(4), FBXW7(9), FZR1(3), ITCH(2), SMURF1(1), SMURF2(5), TCEB1(1), UBA1(2), UBE2D3(3), UBE2E1(1), UBE2E2(2), VHL(2), WWP1(1), WWP2(5)	7990437	82	45	81	39	50	4	6	13	8	1	0.710	1.000	1.000
376	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(9), ARHGEF1(1), GNA12(2), GNA13(1), GNAQ(1), MYL2(4), MYLK(22), PLCB1(33), PPP1R12B(5), PRKCA(8), ROCK1(3)	4175455	89	45	83	41	74	3	2	6	4	0	0.202	1.000	1.000
377	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), DAB1(30), FYN(5), LRP8(3), RELN(46), VLDLR(4)	2800281	91	45	88	41	69	4	2	7	9	0	0.376	1.000	1.000
378	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(12), AXIN1(6), BTRC(4), CCND1(1), CREBBP(14), CSNK1A1(2), CSNK1D(1), CSNK2A1(1), CTNNB1(6), FZD1(1), GSK3B(2), HDAC1(1), MYC(2), NLK(4), PPARD(2), PPP2CA(1), TLE1(2), WIF1(5), WNT1(1)	5848071	68	45	67	36	37	5	6	7	13	0	0.815	1.000	1.000
379	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(3), AGPAT3(3), AGPAT4(5), AGPAT6(2), AGPS(3), CHPT1(1), ENPP6(8), PAFAH1B1(2), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7), PLD1(7), PLD2(3), PPAP2B(4), PPAP2C(6)	4683854	95	44	93	47	63	8	3	10	11	0	0.285	1.000	1.000
380	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(10), ABP1(11), AOC2(5), AOC3(6), CES1(12), CES7(10), DDHD1(5), LIPA(1), MYST3(10), MYST4(11), NAT6(2), PLA1A(4), PNPLA3(1), PPME1(1), PRDX6(2), SH3GLB1(2)	5098401	93	44	92	50	73	4	7	4	5	0	0.604	1.000	1.000
381	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(3), AASDH(4), AASDHPPT(1), AASS(1), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), BBOX1(3), DOT1L(5), EHHADH(5), EHMT1(6), EHMT2(4), GCDH(3), HADHA(7), PLOD1(1), PLOD2(5), PLOD3(1), SHMT2(2), TMLHE(1)	7374880	79	44	78	44	51	9	2	10	7	0	0.451	1.000	1.000
382	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(3), GTF2A1(2), GTF2B(1), GTF2F1(2), HDAC3(3), NCOA1(8), NCOA2(12), NCOA3(8), NCOR2(15), POLR2A(10), RARA(1), RXRA(1), TBP(4)	4978884	70	44	68	33	54	3	4	6	3	0	0.329	1.000	1.000
383	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(3), ACTN1(2), ACTN2(14), ACTN3(5), CAPN1(1), CAPNS1(1), ITGA1(15), ITGB1(4), ITGB3(9), PTK2(3), PXN(3), RAC1(9), SPTAN1(4), SRC(1), TLN1(10)	5635202	84	44	79	47	59	5	3	9	7	1	0.215	1.000	1.000
384	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(17), ADRB2(1), CFTR(29), GNAS(12), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), SLC9A3R1(3)	2587955	79	43	76	51	59	4	4	6	6	0	0.718	1.000	1.000
385	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(14), EGFR(16), MAP2K1(7), MAPK14(4), NCOR2(15), RARA(1), RXRA(1), THRA(1), THRB(12)	3431333	71	43	68	45	51	6	1	10	3	0	0.827	1.000	1.000
386	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(4), F2(6), F2R(4), F5(20), F7(2), FGA(20), FGB(7), FGG(4), PROC(7), PROS1(9), SERPINC1(5), TFPI(5)	3292580	93	43	90	43	69	8	5	5	6	0	0.321	1.000	1.000
387	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(2), CHIA(8), CHIT1(7), CTBS(4), CYB5R1(1), GFPT1(1), GFPT2(4), GNE(3), HEXA(5), HEXB(2), HK1(1), HK2(5), HK3(10), LHPP(1), MTMR1(3), MTMR2(1), MTMR6(2), NANS(1), PGM3(1), RENBP(2), UAP1(1)	5744964	65	43	63	39	45	5	3	6	6	0	0.627	1.000	1.000
388	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GALNS(2), GLB1(5), GUSB(3), HEXA(5), HEXB(2), HGSNAT(4), HPSE(6), HPSE2(3), HYAL2(1), IDS(5), IDUA(4), LCT(31), NAGLU(3), SPAM1(14)	4073106	88	43	87	52	63	6	2	9	8	0	0.613	1.000	1.000
389	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(1), EIF2B5(1), EIF2S1(1), GSK3B(2), IGF1(7), IGF1R(6), INPPL1(11), PDK2(4), PDPK1(3), PIK3CA(2), PIK3R1(2), PPP2CA(1), PTEN(12), RPS6(1), RPS6KB1(2)	3934542	56	43	55	23	27	6	7	6	10	0	0.361	1.000	1.000
390	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(3), ADCY1(17), CDC25C(3), GNAI1(1), GNAS(12), HRAS(1), MAPK1(3), MAPK3(1), MYT1(15), PIN1(1), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RPS6KA1(4), SRC(1)	4104040	79	43	79	54	60	3	2	6	8	0	0.745	1.000	1.000
391	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(26), ABCB11(35), ABCB4(9), ABCC1(8), ABCC3(20)	2851612	98	43	94	51	68	9	2	6	13	0	0.0233	1.000	1.000
392	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(4), DYRK1B(2), GLI2(23), GLI3(8), GSK3B(2), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), SHH(2), SMO(6), SUFU(2)	3320172	66	43	64	37	48	7	3	4	4	0	0.410	1.000	1.000
393	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(8), AGT(3), AGTR2(3), EDN1(7), EDNRA(4), EDNRB(4), EGF(14), EGFR(16), FOS(1), HRAS(1), JUN(1), MYC(2), NFKB1(3), PLCG1(4), PRKCA(8), RELA(2)	4118859	81	42	79	51	62	5	2	7	5	0	0.706	1.000	1.000
394	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(6), CSF1R(9), EGF(14), EGFR(16), GRB2(2), MET(12), PDGFRA(15), PRKCA(8), SH3GLB1(2), SH3KBP1(3), SRC(1)	3911540	88	42	87	60	60	6	3	8	11	0	0.941	1.000	1.000
395	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(12), G6PD(2), GCLC(4), GCLM(1), GGT1(4), GPX1(2), GPX3(2), GPX5(6), GPX6(7), GSR(2), GSS(5), GSTA1(5), GSTA2(1), GSTA3(1), GSTA5(2), GSTK1(1), GSTM1(1), GSTM2(2), GSTM3(2), GSTM4(1), GSTM5(3), GSTT1(1), IDH1(7), MGST1(1), MGST2(1), OPLAH(8)	4376349	84	42	79	51	56	7	2	14	5	0	0.430	1.000	1.000
396	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(15), CD38(3), ENPP1(9), ENPP3(10), NADK(2), NADSYN1(2), NMNAT2(3), NMNAT3(4), NNMT(8), NNT(3), NT5C1A(1), NT5C1B(16), NT5C2(1), NT5C3(2), NT5E(4), NT5M(1), NUDT12(1), QPRT(5)	4324875	90	42	87	57	59	9	5	8	9	0	0.848	1.000	1.000
397	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), BAIAP2(3), CASP1(3), CASP3(1), CASP7(4), CASP8(2), INSR(13), ITCH(2), MAGI1(19), MAGI2(16), RERE(12), WWP1(1), WWP2(5)	4835681	84	42	83	43	59	5	3	13	3	1	0.631	1.000	1.000
398	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), IL2(4), IL2RA(4), IL2RB(7), IL2RG(2), JAK1(4), JAK3(5), JUN(1), LCK(9), MAP2K1(7), MAPK3(1), RAF1(2), SHC1(1), SOS1(6), STAT5A(2), STAT5B(4), SYK(11)	4603974	76	42	72	35	51	7	4	9	5	0	0.210	1.000	1.000
399	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(2), CS(1), DLAT(2), DLD(1), FH(3), IDH3A(3), IDH3G(2), MDH1(1), MDH2(2), OGDH(8), PC(6), PDHA1(1), PDHA2(9), PDHB(1), PDHX(2), PDK1(1), PDK2(4), PDK3(3), PDK4(7), PDP2(4), SDHA(1), SDHC(2), SUCLG1(1), SUCLG2(2)	5717506	69	42	67	31	47	2	5	6	9	0	0.225	1.000	1.000
400	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(14), EP300(8), IKBKB(2), IL1B(5), IL8(1), MAP2K3(4), MAP2K6(2), MAP3K14(1), MAPK11(1), MAPK14(4), MYD88(2), NFKB1(3), NFKBIA(2), NR3C1(2), RELA(2), TGFBR2(5), TLR2(10), TNF(1)	5960966	70	42	70	42	46	10	3	6	5	0	0.829	1.000	1.000
401	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(5), GBA3(6), LPO(11), MPO(6), PRDX1(1), PRDX2(2), PRDX6(2), TPO(30), TYR(5)	1941302	68	42	65	39	55	4	1	3	5	0	0.314	1.000	1.000
402	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), CARS(6), DARS(2), EPRS(6), FARS2(3), GARS(5), HARS(3), IARS(5), KARS(3), LARS(8), LARS2(3), MARS(5), MARS2(3), NARS(2), QARS(6), RARS(5), SARS(4), TARS(1), WARS(3), WARS2(1), YARS(1)	6484002	79	41	76	27	49	8	5	8	9	0	0.0375	1.000	1.000
403	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(8), ALDOC(1), DERA(1), FBP1(1), FBP2(1), G6PD(2), GPI(2), H6PD(4), PFKL(2), PGD(3), PGLS(1), PGM1(2), PGM3(1), PRPS1(1), PRPS1L1(8), PRPS2(1), RBKS(3), TALDO1(3), TKT(5), TKTL1(1), TKTL2(14)	4862631	66	41	65	55	42	8	3	4	9	0	0.900	1.000	1.000
404	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(8), CYP2A13(6), CYP2A6(9), CYP2A7(6), NAT1(1), NAT2(6), XDH(38)	1616225	74	41	73	46	63	1	5	2	3	0	0.120	1.000	1.000
405	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), GLB1(5), HEXA(5), HEXB(2), LCT(31), MAN2B1(6), MAN2B2(4), MAN2C1(1), MANBA(4), NEU1(4), NEU2(12), NEU3(2), NEU4(7)	4063940	86	41	85	50	69	7	1	8	1	0	0.472	1.000	1.000
406	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(2), CREBBP(14), EP300(8), FYN(5), IL2RG(2), IL7(3), IL7R(15), JAK1(4), JAK3(5), LCK(9), PIK3CA(2), PIK3R1(2), PTK2B(7), STAT5A(2), STAT5B(4)	5591345	84	41	83	45	56	11	4	7	6	0	0.599	1.000	1.000
407	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(17), ADRB2(1), GNAS(12), PLCE1(27), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4)	2917510	74	41	74	46	55	3	5	5	6	0	0.709	1.000	1.000
408	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(1), AKT2(6), AKT3(3), BCL2(2), GRB2(2), GSK3B(2), IL4R(7), IRS1(3), IRS2(1), JAK1(4), JAK3(5), MAP4K1(6), MAPK1(3), MAPK3(1), PDK1(1), PIK3CA(2), PIK3CD(2), PIK3R1(2), PPP1R13B(5), RAF1(2), SHC1(1), SOS1(6), SOS2(3), STAT6(5)	7310294	75	41	75	39	51	12	2	5	5	0	0.447	1.000	1.000
409	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(17), GNAS(12), PPP2CA(1), PRKAA1(1), PRKAA2(18), PRKAB2(1), PRKACB(2), PRKACG(7), PRKAG1(2), PRKAG2(3), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4)	3057631	72	40	71	42	55	4	3	3	7	0	0.641	1.000	1.000
410	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(7), GABRA1(8), GABRA2(10), GABRA3(14), GABRA4(6), GABRA5(2), GABRA6(17), GPHN(1), NSF(1), SRC(1), UBQLN1(4)	2345599	71	40	65	42	60	3	1	1	6	0	0.517	1.000	1.000
411	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(4), JUN(1), MAP2K1(7), MAP2K4(3), MAPK3(1), PDGFA(1), PDGFRA(15), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(8), RAF1(2), RASA1(1), SHC1(1), SOS1(6), SRF(1), STAT1(2), STAT3(6), STAT5A(2)	6978496	75	40	71	41	48	7	4	10	6	0	0.708	1.000	1.000
412	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1(4), CAMK1G(9), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(9), ESRRA(1), HDAC5(3), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), PPARA(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), SLC2A4(6), SYT1(12)	4017272	75	40	75	48	57	5	2	7	4	0	0.652	1.000	1.000
413	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(2), PIK3R1(2), PLCB1(33), PLCG1(4), PRKCA(8), VAV1(13)	2580439	63	40	59	32	54	2	0	4	3	0	0.384	1.000	1.000
414	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), CHUK(1), EGR2(4), EGR3(1), GNAQ(1), MYC(2), NFATC1(13), NFATC2(6), NFKB1(3), NFKBIA(2), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RELA(2), SYT1(12), VIP(3), VIPR2(4)	5583301	82	40	82	60	64	6	4	4	4	0	0.945	1.000	1.000
415	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(23), AGT(3), AGTR1(7), AGTR2(3), BDKRB2(2), KNG1(4), NOS3(13), REN(8)	1979996	63	39	60	46	45	4	1	6	7	0	0.597	1.000	1.000
416	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3D(5), CD3E(2), CD80(3), CD86(16), CTLA4(1), GRB2(2), HLA-DRA(7), HLA-DRB1(2), ICOS(2), IL2(4), ITK(19), LCK(9), PIK3CA(2), PIK3R1(2), PTPN11(5)	2564266	81	39	79	30	56	7	1	9	8	0	0.134	1.000	1.000
417	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(3), EPHA4(11), EPHB1(17), FYN(5), ITGA1(15), ITGB1(4), L1CAM(5), LYN(3), SELP(15)	3164032	78	39	74	44	56	4	1	10	7	0	0.579	1.000	1.000
418	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(12), G6PD(2), GCLC(4), GCLM(1), GGT1(4), GPX1(2), GPX3(2), GPX5(6), GSS(5), GSTA1(5), GSTA2(1), GSTA3(1), GSTM1(1), GSTM2(2), GSTM3(2), GSTM4(1), GSTM5(3), GSTT1(1), IDH1(7), MGST1(1), MGST2(1), PGD(3)	3623329	67	39	62	34	43	5	2	12	5	0	0.210	1.000	1.000
419	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(9), BCAT2(1), IARS(5), IARS2(10), ILVBL(2), LARS(8), LARS2(3), PDHA1(1), PDHA2(9), PDHB(1), VARS(14), VARS2(4)	3799230	67	39	63	23	46	8	1	6	6	0	0.0609	1.000	1.000
420	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(4), EPX(5), LPO(11), MPO(6), PRDX1(1), PRDX2(2), PRDX6(2), SHMT2(2), TPO(30)	2378086	63	39	60	36	52	4	1	3	3	0	0.201	1.000	1.000
421	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(2), CNR1(7), CNR2(1), DNMT1(13), MTNR1A(6), MTNR1B(5), PTAFR(1), PTGDR(7), PTGER2(5), PTGFR(13), PTGIR(3), TBXA2R(3)	2234610	66	39	62	50	46	6	3	4	7	0	0.425	1.000	1.000
422	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(16), HLA-DRA(7), HLA-DRB1(2), IFNG(2), IFNGR1(3), IFNGR2(2), IL12A(2), IL12B(3), IL12RB1(9), IL12RB2(3), IL18(2), IL18R1(14), IL2(4), IL2RA(4), IL4(1), IL4R(7)	2541661	81	39	80	31	63	5	0	5	8	0	0.0399	1.000	1.000
423	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(4), ALOX15(4), ALOX15B(5), ALOX5(8), ALOX5AP(1), DPEP1(3), GGT1(4), LTA4H(2), PLA2G2A(2), PLA2G6(7), PTGDS(2), PTGIS(9), PTGS1(14), PTGS2(6), TBXAS1(8)	2989502	79	38	78	44	56	6	2	9	6	0	0.126	1.000	1.000
424	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(7), POLR1B(5), POLR1C(1), POLR2A(10), POLR2B(11), POLR2D(1), POLR2E(1), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(2), POLR3B(12), POLR3GL(1), POLR3K(1)	4720224	57	38	57	23	33	8	4	8	4	0	0.208	1.000	1.000
425	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(2), IL1A(3), IL1R1(7), MAP3K14(1), MYD88(2), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TLR4(26), TNF(1), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRAF6(2)	4796893	58	38	55	40	42	3	2	5	6	0	0.879	1.000	1.000
426	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(23), CD44(5), CSF1(8), FCGR3A(5), IL1B(5), IL6R(2), SELL(6), SPN(5), TGFB2(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(11), TNFSF8(2)	2590590	77	38	75	31	61	5	2	2	7	0	0.0210	1.000	1.000
427	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(4), BIRC3(6), CASP3(1), CASP8(2), CFLAR(3), JUN(1), MAP2K4(3), MAP3K3(4), NFKB1(3), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NR2C2(2), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2)	5421857	50	38	50	28	25	5	6	11	3	0	0.659	1.000	1.000
428	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(20), CD3D(5), CD3E(2), CD8A(2), ICAM1(2), ITGAL(17), ITGB2(10), PTPRC(18)	2125902	76	38	70	32	60	2	0	6	8	0	0.0262	1.000	1.000
429	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(12), CDH1(4), CREBBP(14), EP300(8), MAP2K1(7), MAPK3(1), SKIL(1), TGFB2(1), TGFB3(1), TGFBR2(5)	5163446	54	38	51	25	33	5	2	6	8	0	0.740	1.000	1.000
430	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(20), CD3D(5), CD3E(2), CD4(4), ICAM1(2), ITGAL(17), ITGB2(10), PTPRC(18)	2229038	78	38	72	38	60	3	0	7	8	0	0.0930	1.000	1.000
431	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(2), BAG4(1), CASP2(1), CASP3(1), CASP8(2), CRADD(1), DFFA(1), DFFB(2), JUN(1), LMNA(3), LMNB1(1), LMNB2(4), MADD(7), MAP2K4(3), PAK1(2), PAK2(2), PRKDC(13), RB1(3), RIPK1(1), SPTAN1(4), TNF(1), TNFRSF1A(2), TRAF2(2)	7824495	60	38	59	32	32	7	6	8	5	2	0.569	1.000	1.000
432	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(5), CHAT(11), COMT(2), DBH(5), DDC(7), GAD1(7), GAD2(4), HDC(8), MAOA(2), PAH(3), PNMT(4), SLC18A3(2), TH(7), TPH1(2)	2828560	70	37	70	56	55	6	2	2	5	0	0.808	1.000	1.000
433	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(8), ALDOC(1), FBP1(1), FBP2(1), GOT1(4), GOT2(2), GPT(3), MDH1(1), MDH2(2), ME1(14), ME2(1), ME3(6), PGK1(2), PKLR(6), PKM2(5), TKT(5)	3634375	63	37	62	32	44	5	4	5	5	0	0.127	1.000	1.000
434	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(2), ACO2(2), CS(1), DLD(1), FH(3), IDH1(7), IDH3A(3), IDH3G(2), MDH1(1), MDH2(2), PC(6), PCK1(20), SDHA(1), SUCLG1(1), SUCLG2(2)	4168676	54	37	48	30	40	1	5	5	3	0	0.425	1.000	1.000
435	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(4), B3GNT1(2), B3GNT2(2), B3GNT3(4), B3GNT4(2), B3GNT5(1), B4GALT1(1), B4GALT2(2), B4GALT3(2), FUT1(3), FUT2(2), FUT3(4), FUT4(1), FUT5(6), FUT6(1), FUT7(2), FUT9(14), ST3GAL6(2)	3197945	55	37	55	29	37	9	3	2	4	0	0.200	1.000	1.000
436	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(7), ASRGL1(1), CA1(8), CA12(3), CA13(5), CA2(5), CA3(3), CA4(1), CA5A(2), CA5B(1), CA6(3), CA7(1), CA8(4), CA9(5), CPS1(13), GLS(1), GLS2(3), GLUD1(1), GLUD2(1), HAL(8)	4221794	77	37	76	34	57	7	3	6	4	0	0.150	1.000	1.000
437	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(5), GBA(2), GBA3(6), LPO(11), MPO(6), PRDX6(2), TPO(30)	1685272	62	37	59	39	51	4	1	3	3	0	0.371	1.000	1.000
438	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(5), CD3D(5), CD3E(2), CXCR3(2), ETV5(4), IFNG(2), IL12A(2), IL12B(3), IL12RB1(9), IL12RB2(3), IL18(2), IL18R1(14), JAK2(6), JUN(1), MAP2K6(2), MAPK14(4), STAT4(13), TYK2(4)	3720369	83	37	83	46	64	6	2	7	4	0	0.571	1.000	1.000
439	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(16), CPT1A(7), LEP(1), LEPR(13), PRKAA1(1), PRKAA2(18), PRKAB2(1), PRKAG1(2), PRKAG2(3)	2936945	62	37	60	36	46	4	2	3	7	0	0.766	1.000	1.000
440	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), GLB1(5), HEXA(5), HEXB(2), LCT(31), MAN2C1(1), MANBA(4), NEU1(4), NEU2(12), NEU3(2), NEU4(7)	3297721	76	37	75	44	61	6	1	7	1	0	0.567	1.000	1.000
441	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(10), ATR(13), CDC25C(3), CHEK1(1), TP53(26)	3214053	53	37	49	19	30	1	4	6	12	0	0.412	1.000	1.000
442	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(1), AKT2(6), AKT3(3), GRB2(2), MAPK1(3), MAPK3(1), PDK1(1), PIK3CA(2), PIK3CD(2), PTEN(12), PTK2B(7), RBL2(2), SHC1(1), SOS1(6)	4115540	49	37	49	22	25	4	2	8	10	0	0.593	1.000	1.000
443	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(5), APOA1(2), APOA4(5), APOC1(1), CETP(4), CYP7A1(5), HMGCR(8), LDLR(10), LIPC(6), LPL(2), LRP1(22), SCARB1(4), SOAT1(3)	5559465	77	37	76	45	48	9	4	9	7	0	0.389	1.000	1.000
444	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(1), ALDOB(8), ALDOC(1), FBP1(1), FBP2(1), FPGT(2), GCK(10), GMDS(4), GMPPA(1), GMPPB(2), HK1(1), HK2(5), HK3(10), KHK(1), MPI(1), PFKFB1(2), PFKFB3(2), PFKFB4(4), SORD(1)	4773975	60	36	57	46	44	8	3	2	3	0	0.638	1.000	1.000
445	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), BCL2(2), BCR(6), FOS(1), GRB2(2), HRAS(1), JAK2(6), JUN(1), MAP2K1(7), MAP2K4(3), MAPK3(1), MYC(2), PIK3CA(2), PIK3R1(2), RAF1(2), SOS1(6), STAT1(2), STAT5A(2), STAT5B(4)	5600018	53	36	50	31	31	6	5	9	2	0	0.806	1.000	1.000
446	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(4), EPX(5), LPO(11), MPO(6), MTHFR(1), PRDX6(2), SHMT2(2), TPO(30)	2350046	61	36	58	38	51	4	1	3	2	0	0.315	1.000	1.000
447	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG5(2), ATG7(5), BECN1(1), GABARAPL1(1), IFNA10(2), IFNA14(6), IFNA16(6), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA6(1), IFNA7(2), IFNA8(3), IFNG(2), PIK3C3(1), PIK3R4(2), PRKAA1(1), PRKAA2(18), ULK1(4), ULK2(5), ULK3(1)	4187778	75	36	73	38	57	5	4	6	3	0	0.290	1.000	1.000
448	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), INSR(13), IRS1(3), JUN(1), MAP2K1(7), MAPK3(1), PIK3CA(2), PIK3R1(2), PTPN11(5), RAF1(2), RASA1(1), SHC1(1), SLC2A4(6), SOS1(6), SRF(1)	5131924	57	36	54	28	31	8	1	14	3	0	0.621	1.000	1.000
449	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(15), CD38(3), ENPP1(9), ENPP3(10), NADSYN1(2), NMNAT2(3), NNMT(8), NNT(3), NT5E(4), NT5M(1), QPRT(5)	2924629	63	36	60	33	44	7	3	4	5	0	0.466	1.000	1.000
450	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(7), CA1(8), CA12(3), CA2(5), CA3(3), CA4(1), CA5A(2), CA5B(1), CA6(3), CA7(1), CA8(4), CA9(5), CPS1(13), GLS(1), GLS2(3), GLUD1(1), HAL(8)	3773875	70	36	69	31	51	6	3	6	4	0	0.173	1.000	1.000
451	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(5), CD2(20), CD3D(5), CD3E(2), CD4(4), CXCR3(2), IFNG(2), IL12A(2), IL12B(3), IL12RB1(9), IL12RB2(3), JAK2(6), STAT4(13), TYK2(4)	2913066	80	36	77	47	59	7	2	7	5	0	0.520	1.000	1.000
452	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), FOS(1), GRB2(2), HRAS(1), JAK2(6), JUN(1), MAP2K1(7), MAPK3(1), MPL(2), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(8), RAF1(2), RASA1(1), SHC1(1), SOS1(6), STAT1(2), STAT3(6), STAT5A(2), STAT5B(4), THPO(4)	5985736	66	36	62	35	42	6	4	10	4	0	0.697	1.000	1.000
453	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(4), CREBBP(14), EP300(8), NCOA3(8), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RARA(1), RXRA(1)	4159025	53	35	53	29	36	3	2	7	5	0	0.787	1.000	1.000
454	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(8), GABRA2(10), GABRA3(14), GABRA4(6), GABRA5(2), GABRA6(17), GPX1(2), PRKCE(4)	1543377	63	35	58	35	50	5	0	3	5	0	0.387	1.000	1.000
455	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), IGF1(7), IGF1R(6), IRS1(3), JUN(1), MAP2K1(7), MAPK3(1), PIK3CA(2), PIK3R1(2), PTPN11(5), RAF1(2), RASA1(1), SHC1(1), SOS1(6), SRF(1)	4959324	51	35	48	27	30	9	1	9	2	0	0.697	1.000	1.000
456	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(14), FOS(1), GRB2(2), HRAS(1), IL3(2), IL3RA(4), JAK2(6), MAP2K1(7), MAPK3(1), PTPN6(1), RAF1(2), SHC1(1), SOS1(6), STAT5A(2), STAT5B(4)	3519191	54	35	51	29	34	3	3	8	6	0	0.536	1.000	1.000
457	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(3), CALM2(1), CAPN2(2), CAPNS1(1), EP300(8), HDAC1(1), MEF2D(2), NFATC1(13), NFATC2(6), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKCA(8), SYT1(12)	4925562	63	35	62	35	48	5	4	3	3	0	0.579	1.000	1.000
458	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(13), AP2A1(1), BIN1(1), CALM2(1), DNM1(7), EPN1(5), EPS15(1), PICALM(1), PPP3CA(4), PPP3CB(1), PPP3CC(1), SYNJ1(11), SYNJ2(11), SYT1(12)	4280377	70	35	69	37	53	6	2	7	2	0	0.512	1.000	1.000
459	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(8), ALDOC(1), FBP1(1), FBP2(1), G6PD(2), GPI(2), H6PD(4), PGD(3), PGLS(1), PGM1(2), PGM3(1), PRPS1(1), PRPS1L1(8), PRPS2(1), RBKS(3), TAL1(5), TALDO1(3), TKT(5)	4097055	53	35	52	45	32	6	3	5	7	0	0.927	1.000	1.000
460	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(1), CCND1(1), CCNE1(3), CDK4(2), CDK6(1), CDKN1A(2), CDKN1B(1), E2F1(5), HRAS(1), MAPK1(3), MAPK3(1), NFKB1(3), NFKBIA(2), PAK1(2), PIK3CA(2), PIK3R1(2), RAC1(9), RAF1(2), RB1(3), RELA(2), TFDP1(1)	4034691	49	35	45	27	31	5	3	5	3	2	0.591	1.000	1.000
461	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(4), BIRC3(6), CASP10(4), CASP3(1), CASP7(4), CASP8(2), CASP9(3), DFFA(1), DFFB(2), GZMB(2), PRF1(6), SCAP(6), SREBF1(3), SREBF2(6)	3648080	53	35	52	24	33	5	6	6	3	0	0.232	1.000	1.000
462	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(3), ACTR2(2), ARPC1B(2), ARPC2(1), ARPC3(1), NCKAP1(2), NTRK1(10), RAC1(9), WASF1(1), WASF2(4), WASF3(11), WASL(3)	3071011	49	34	44	23	38	2	2	4	3	0	0.539	1.000	1.000
463	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(14), ACTN3(5), BCAR1(3), CSK(1), CTNNA1(2), CTNNA2(17), CTNNB1(6), PTK2(3), PXN(3), SRC(1), VCL(4)	3773226	61	34	61	42	40	2	1	10	7	1	0.749	1.000	1.000
464	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), MAP2K1(7), MAP2K2(2), MAP2K3(4), MAP2K6(2), MAPK1(3), MAPK14(4), MAPK3(1), NFKB1(3), PIK3CA(2), PIK3R1(2), RB1(3), RELA(2), SP1(4)	3869272	40	34	37	26	23	5	2	4	4	2	0.926	1.000	1.000
465	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(5), ASPH(3), COPS5(2), EDN1(7), EP300(8), EPO(4), HIF1A(1), JUN(1), LDHA(2), NOS3(13), P4HB(2), VHL(2)	3435435	50	34	48	22	36	3	3	4	4	0	0.380	1.000	1.000
466	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(1), GLB1(5), HEXA(5), HEXB(2), LCT(31), SLC33A1(4), ST3GAL1(5), ST3GAL5(2), ST6GALNAC3(4), ST6GALNAC5(5), ST6GALNAC6(2), ST8SIA5(5)	3308001	72	34	71	45	50	6	1	10	5	0	0.642	1.000	1.000
467	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(29), CYP2C9(28)	403785	57	34	53	36	49	3	2	0	3	0	0.524	1.000	1.000
468	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(14), EP300(8), LPL(2), NCOA1(8), NCOA2(12), PPARG(8), RXRA(1)	3740863	53	34	51	20	40	4	2	4	3	0	0.289	1.000	1.000
469	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(1), BCAR1(3), CDKN1B(1), GRB2(2), ITGB1(4), MAPK1(3), MAPK3(1), PDK2(4), PDPK1(3), PIK3CA(2), PIK3R1(2), PTEN(12), PTK2(3), SHC1(1), SOS1(6)	3832554	48	34	47	20	25	3	2	9	9	0	0.629	1.000	1.000
470	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(1), AKT1(1), ANXA1(3), CALM2(1), GNAS(12), NFKB1(3), NOS3(13), NPPA(1), NR3C1(2), PIK3CA(2), PIK3R1(2), RELA(2), SYT1(12)	3552645	55	33	54	42	45	4	2	3	1	0	0.968	1.000	1.000
471	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(3), ACOX1(3), ACOX3(5), ELOVL2(2), ELOVL6(2), FADS2(2), FASN(9), HADHA(7), HSD17B12(1), PECR(1), SCD(2)	2868169	37	33	37	22	24	4	1	4	4	0	0.365	1.000	1.000
472	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(3), CASP2(1), CHUK(1), CRADD(1), IKBKB(2), JUN(1), LTA(2), MAP2K3(4), MAP2K4(3), MAP2K6(2), MAP3K14(1), MAP4K2(4), MAPK14(4), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TNF(1), TNFRSF1A(2), TRAF2(2)	4762222	42	33	42	33	25	6	2	4	5	0	0.944	1.000	1.000
473	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(5), CD3E(2), CD4(4), FYN(5), HLA-DRA(7), HLA-DRB1(2), LCK(9), PTPRC(18), ZAP70(4)	1767728	56	33	53	28	41	6	0	6	3	0	0.320	1.000	1.000
474	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(5), CHUK(1), IFNG(2), IKBKB(2), IL2(4), IL4(1), JUN(1), MAP3K5(11), MAP4K5(3), MAPK14(4), NFKB1(3), NFKBIA(2), RELA(2), TNFRSF9(3), TNFSF9(1), TRAF2(2)	3833868	47	32	47	24	29	3	1	7	7	0	0.615	1.000	1.000
475	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(20), MAP2(7), PPP1CA(1), PPP2CA(1), PRKACB(2), PRKACG(7), PRKAG1(2), PRKAR2A(1), PRKAR2B(4), PRKCE(4)	3626999	49	32	49	26	30	5	1	6	7	0	0.797	1.000	1.000
476	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM2(1), CDKN1A(2), GNAQ(1), MARCKS(1), NFATC1(13), NFATC2(6), NFATC3(6), NFATC4(5), PLCG1(4), PPP3CA(4), PPP3CB(1), PPP3CC(1), PRKCA(8), SP1(4), SP3(1), SYT1(12)	4198103	70	32	69	35	52	9	3	2	4	0	0.421	1.000	1.000
477	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(16), ACACB(14), FASN(9), MCAT(1), OLAH(8), OXSM(1)	3171641	49	32	48	26	32	5	2	6	4	0	0.318	1.000	1.000
478	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(4), DHRS1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(3), HEMK1(1), LCMT1(4), METTL2B(6), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), WBSCR22(1)	3031204	49	32	48	25	27	8	2	10	2	0	0.443	1.000	1.000
479	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), IL6R(2), IL6ST(6), JAK1(4), JAK2(6), JAK3(5), JUN(1), MAP2K1(7), MAPK3(1), PTPN11(5), RAF1(2), SHC1(1), SOS1(6), SRF(1), STAT3(6)	4762567	59	32	56	32	34	8	2	11	4	0	0.691	1.000	1.000
480	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(5), ACADS(2), ACADVL(1), ACSL1(3), ACSL3(3), CPT1A(7), CPT2(1), DCI(2), EHHADH(5), HADHA(7), PECR(1)	3412070	39	32	36	16	28	1	2	4	4	0	0.297	1.000	1.000
481	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(3), ATP6AP1(1), ATP6V0A1(5), ATP6V0A4(12), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C2(6), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), FDXR(7)	3223397	53	32	53	34	32	3	2	9	7	0	0.682	1.000	1.000
482	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6R(2), JAK1(4), JAK2(6), JAK3(5), PIAS3(3), PTPRU(12), REG1A(5), SRC(1), STAT3(6)	3041327	46	32	46	29	29	4	2	6	5	0	0.626	1.000	1.000
483	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(3), ATP6AP1(1), ATP6V0A1(5), ATP6V0A4(12), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C2(6), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5)	3030024	46	31	46	31	27	3	2	8	6	0	0.767	1.000	1.000
484	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(3), ATP6AP1(1), ATP6V0A1(5), ATP6V0A4(12), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C2(6), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5)	3030024	46	31	46	31	27	3	2	8	6	0	0.767	1.000	1.000
485	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(8), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(4), MAPK14(4), NFATC1(13), NFATC2(6), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4)	2414728	60	31	58	32	45	6	1	3	5	0	0.239	1.000	1.000
486	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(2), B3GAT2(2), B3GAT3(3), CHPF(3), CHST11(4), CHST12(1), CHST13(2), CHST14(2), CHSY1(5), DSE(9), XYLT1(8), XYLT2(2)	2658019	43	31	43	35	27	6	2	6	2	0	0.843	1.000	1.000
487	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(4), CSF1(8), CSF2(2), CSF3(2), HLA-DRA(7), HLA-DRB1(2), IFNB1(5), IFNG(2), IL10(2), IL11(2), IL12A(2), IL12B(3), IL13(2), IL15(1), IL1A(3), IL2(4), IL3(2), IL4(1), IL5(4), IL7(3), IL8(1), LTA(2), PDGFA(1), TGFB2(1), TGFB3(1), TNF(1)	2635610	68	31	67	37	49	6	1	4	8	0	0.0935	1.000	1.000
488	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(12), AXIN1(6), BTRC(4), CTNNB1(6), DLL1(2), FZD1(1), GSK3B(2), NOTCH1(4), PSEN1(1), WNT1(1)	4221516	40	31	40	26	19	5	3	4	9	0	0.924	1.000	1.000
489	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), CASP9(3), CHUK(1), ELK1(1), H2AFX(1), HRAS(1), MAP2K1(7), MAPK3(1), NFKB1(3), PIK3CA(2), PIK3R1(2), RAC1(9), RAF1(2), RALBP1(2), RALGDS(3), RELA(2)	3780383	41	31	34	28	29	6	1	5	0	0	0.836	1.000	1.000
490	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(4), JAK2(6), JAK3(5), PIAS1(2), PIAS3(3), PTPRU(12), REG1A(5), SOAT1(3)	2735318	42	31	42	20	27	3	2	6	4	0	0.328	1.000	1.000
491	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(3), ATP6AP1(1), ATP6V0A1(5), ATP6V0A4(12), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C2(6), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5)	3030024	46	31	46	31	27	3	2	8	6	0	0.767	1.000	1.000
492	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1(4), CAMK1G(9), CAMK2A(4), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(9), CAMKK1(1), CAMKK2(4), SYT1(12)	2331722	52	30	52	42	39	5	2	3	3	0	0.895	1.000	1.000
493	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), ARHGDIB(2), BIRC2(4), BIRC3(6), CASP1(3), CASP10(4), CASP2(1), CASP3(1), CASP4(1), CASP7(4), CASP8(2), CASP9(3), CYCS(1), DFFA(1), DFFB(2), GZMB(2), LMNA(3), LMNB1(1), LMNB2(4), PRF1(6)	3929288	54	30	54	21	32	8	5	7	2	0	0.152	1.000	1.000
494	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(10), CDC25A(6), CDC25B(3), CDC25C(3), CHEK1(1), MYT1(15), WEE1(2)	2768008	40	30	39	23	26	4	1	3	6	0	0.811	1.000	1.000
495	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(1), EPO(4), EPOR(1), FOS(1), GRB2(2), HRAS(1), JAK2(6), JUN(1), MAP2K1(7), MAPK3(1), PLCG1(4), PTPN6(1), RAF1(2), SHC1(1), SOS1(6), STAT5A(2), STAT5B(4)	4269750	46	30	43	27	27	3	4	9	3	0	0.757	1.000	1.000
496	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), KHK(1), LCT(31), MPI(1), PGM1(2), PYGL(4), PYGM(7), TREH(3)	2644560	50	30	50	44	41	3	0	3	3	0	0.852	1.000	1.000
497	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(5), CYP11A1(9), CYP11B2(9), CYP17A1(5), HSD11B1(8), HSD3B1(4), HSD3B2(9)	1383260	49	30	47	37	37	3	0	4	5	0	0.355	1.000	1.000
498	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(5), FADS2(2), PLA2G12B(3), PLA2G2A(2), PLA2G2D(2), PLA2G2E(2), PLA2G2F(5), PLA2G3(14), PLA2G4A(8), PLA2G6(7)	2033650	53	30	53	30	39	5	0	4	5	0	0.353	1.000	1.000
499	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(5), IL22(1), IL22RA1(6), IL22RA2(1), JAK1(4), JAK2(6), JAK3(5), SOCS3(2), STAT1(2), STAT3(6), STAT5A(2), STAT5B(4), TYK2(4)	3646259	48	30	48	33	28	4	7	7	2	0	0.818	1.000	1.000
500	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), CHRNG(1), MUSK(22), PIK3CA(2), PIK3R1(2), PTK2(3), PTK2B(7), RAPSN(1), SRC(1), TERT(4)	3255602	44	29	43	46	35	2	1	5	1	0	0.994	1.000	1.000
501	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GALNS(2), GLB1(5), GUSB(3), HEXA(5), HEXB(2), IDS(5), IDUA(4), LCT(31), NAGLU(3)	2866670	60	29	59	34	45	5	0	6	4	0	0.508	1.000	1.000
502	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(5), DHRS1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(3), EHHADH(5), GCDH(3), HADHA(7), MYST3(10), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(2)	5249385	60	29	58	40	39	7	1	10	3	0	0.937	1.000	1.000
503	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), EHHADH(5), HADHA(7)	2433641	38	29	37	18	23	5	1	5	4	0	0.235	1.000	1.000
504	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(1), CAT(4), GH1(1), GHR(16), HRAS(1), IGF1(7), IGF1R(6), PIK3CA(2), PIK3R1(2), SHC1(1)	2658746	41	29	41	24	29	6	0	4	2	0	0.652	1.000	1.000
505	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(1), BTK(8), EEA1(2), GSK3B(2), LYN(3), PDPK1(3), PFKL(2), PLCG1(4), PRKCE(4), PRKCZ(1), RAC1(9), RPS6KB1(2), VAV2(3)	4947516	45	29	40	28	31	1	3	3	7	0	0.520	1.000	1.000
506	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ARPC1B(2), ARPC2(1), ARPC3(1), PAK1(2), PDGFRA(15), PIK3CA(2), PIK3R1(2), RAC1(9), WASL(3)	2698825	39	28	35	18	30	1	2	3	3	0	0.527	1.000	1.000
507	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), BCL2(2), CASP8(2), CYCS(1), MAP2K1(7), MAP2K4(3), MAPK1(3), MAPK3(1), NFKB1(3), NSMAF(3), RAF1(2), RELA(2), RIPK1(1), SMPD1(1), TNFRSF1A(2), TRAF2(2)	4086149	36	28	33	24	26	4	2	4	0	0	0.822	1.000	1.000
508	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(17), FHL5(6), FSHB(2), FSHR(12), GNAS(12)	1894140	49	28	48	34	38	2	2	3	4	0	0.876	1.000	1.000
509	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(14), EGFR(16), ERBB3(2), NRG1(11)	2079039	43	28	43	29	34	1	1	4	3	0	0.930	1.000	1.000
510	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(4), CHPT1(1), HEMK1(1), LCMT1(4), METTL2B(6), PCYT1A(2), PCYT1B(3), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(7), WBSCR22(1)	2821699	42	28	41	17	23	6	4	6	3	0	0.202	1.000	1.000
511	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(11), AMT(1), ATIC(2), FTCD(1), GART(7), MTFMT(1), MTHFD1(7), MTHFD2(2), MTHFR(1), MTR(5), SHMT2(2), TYMS(1)	3810185	41	28	41	28	27	3	1	5	5	0	0.823	1.000	1.000
512	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), RPL10L(6), RPL11(1), RPL13A(1), RPL14(1), RPL18(3), RPL18A(1), RPL21(1), RPL26(1), RPL27(2), RPL27A(1), RPL3(1), RPL30(1), RPL35(1), RPL38(1), RPL3L(3), RPL7(2), RPS10(1), RPS11(1), RPS13(1), RPS2(1), RPS20(2), RPS24(1), RPS27(1), RPS29(1), RPS5(1), RPS6(1), RPS7(1), RPSA(1)	4529258	41	28	41	28	24	3	4	7	3	0	0.800	1.000	1.000
513	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(5), CLOCK(2), CRY1(3), CRY2(2), CSNK1D(1), CSNK1E(3), NPAS2(3), PER1(4), PER2(10), PER3(7)	3413954	40	28	40	26	29	4	1	3	3	0	0.829	1.000	1.000
514	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), GRB2(2), HRAS(1), IGF1R(6), IRS1(3), MAP2K1(7), MAPK1(3), MAPK3(1), PIK3CA(2), PIK3R1(2), RAF1(2), SHC1(1), SOS1(6)	3815801	37	28	34	20	24	6	1	5	1	0	0.628	1.000	1.000
515	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(20), CD34(2), CD3D(5), CD3E(2), CD4(4), CD58(1), CD8A(2), CSF3(2), IL3(2), IL8(1), KITLG(6)	1232828	47	28	44	25	35	1	1	6	4	0	0.301	1.000	1.000
516	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(1), B4GALT1(1), B4GALT2(2), B4GALT3(2), B4GALT5(2), DDOST(2), DPAGT1(2), DPM1(1), FUT8(5), MAN1A1(8), MAN1B1(2), MGAT1(1), MGAT3(9), MGAT4A(5), MGAT5(2), RPN2(2), ST6GAL1(4)	4011801	52	28	51	37	33	6	1	6	6	0	0.829	1.000	1.000
517	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(8), CYP2E1(8), NR1I3(7), PTGS1(14), PTGS2(6)	1085963	43	27	43	24	32	2	0	4	5	0	0.294	1.000	1.000
518	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(11), AOC2(5), AOC3(6), CES1(12), ESD(1)	1209395	35	27	35	20	32	1	2	0	0	0	0.322	1.000	1.000
519	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(4), ARFGAP3(1), ARFGEF2(7), CLTA(1), CLTB(1), COPA(4), GBF1(7), GPLD1(16)	3298214	41	27	41	28	28	3	0	7	3	0	0.882	1.000	1.000
520	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), JUN(1), MAPK3(1), OPRK1(15), POLR2A(10), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4)	2577158	45	27	45	35	36	1	2	3	3	0	0.882	1.000	1.000
521	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(14), EGFR(16), HGS(3), TF(5), TFRC(3)	2577258	43	27	43	29	32	1	3	3	4	0	0.898	1.000	1.000
522	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(2), B3GNT7(3), B4GALT1(1), B4GALT2(2), B4GALT3(2), CHST1(7), CHST2(2), CHST4(8), CHST6(4), FUT8(5), ST3GAL1(5), ST3GAL4(1)	2499986	44	27	43	23	30	8	3	2	1	0	0.177	1.000	1.000
523	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(5), B3GALT5(1), FUT1(3), FUT2(2), FUT9(14), GBGT1(1), GLA(1), HEXA(5), HEXB(2), NAGA(2), ST3GAL1(5)	2153015	44	27	43	29	31	3	2	6	2	0	0.614	1.000	1.000
524	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(8), CD4(4), HLA-DRA(7), HLA-DRB1(2), IL1B(5), IL4(1), IL5(4), IL5RA(7)	1073777	39	27	38	25	32	1	0	3	3	0	0.375	1.000	1.000
525	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(11), AMT(1), ATIC(2), GART(7), MTHFD1(7), MTHFD2(2), MTHFR(1), MTR(5), SHMT2(2), TYMS(1)	3597680	39	27	39	27	25	3	1	5	5	0	0.836	1.000	1.000
526	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(5), JAK1(4), PTPRU(12), REG1A(5), STAT1(2), STAT2(6), TYK2(4)	2514978	39	27	39	21	23	2	2	6	6	0	0.400	1.000	1.000
527	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(5), F13B(16), HSD17B2(7), HSD17B3(5), HSD17B4(3), HSD3B1(4), HSD3B2(9)	1602698	49	27	47	24	35	2	4	3	4	1	0.227	1.000	1.000
528	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(3), ARG1(1), ARG2(1), ASL(3), CKM(2), CKMT1A(1), CKMT2(5), CPS1(13), GAMT(3), GATM(2), GLUD1(1), OAT(1), ODC1(2), OTC(2), SMS(1)	3457107	41	27	40	22	26	5	3	3	4	0	0.432	1.000	1.000
529	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(12), PRKACB(2), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(8)	1894203	39	26	38	25	32	1	1	2	3	0	0.804	1.000	1.000
530	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), CASP9(3), CHUK(1), GH1(1), GHR(16), NFKB1(3), NFKBIA(2), PDPK1(3), PIK3CA(2), PIK3R1(2), PPP2CA(1), RELA(2)	2800030	37	26	36	28	26	4	3	1	3	0	0.948	1.000	1.000
531	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GCK(10), GFPT1(1), GNE(3), HEXA(5), HEXB(2), HK1(1), HK2(5), HK3(10), PGM3(1), RENBP(2), UAP1(1)	3407507	41	26	39	28	30	3	1	4	3	0	0.773	1.000	1.000
532	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), GRB2(2), HRAS(1), MAPK1(3), MAPK3(1), MAPK7(2), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2), NTRK1(10), PIK3CA(2), PIK3R1(2), PLCG1(4), RPS6KA1(4), SHC1(1)	3786398	41	26	41	33	31	5	1	3	1	0	0.934	1.000	1.000
533	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP51A1(1), DHCR24(1), DHCR7(6), FDPS(3), GGCX(3), GGPS1(1), HMGCR(8), LSS(2), MVD(1), MVK(2), NQO1(1), NSDHL(3), PMVK(1), SC4MOL(3), SC5DL(1), SQLE(2)	3869872	39	26	38	20	20	8	2	6	3	0	0.416	1.000	1.000
534	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(1), KLK2(1), MAP2K1(7), MAPK3(1), NGFR(6), PIK3CA(2), PIK3R1(2), PLCG1(4), RAF1(2), SHC1(1), SOS1(6)	3811003	39	26	36	24	27	5	0	5	2	0	0.816	1.000	1.000
535	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(14), EP300(8), ESR1(2), MAPK1(3), MAPK3(1), PELP1(9), SRC(1)	2940849	38	26	38	18	29	3	2	2	2	0	0.470	1.000	1.000
536	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CCL2(1), CCR5(5), CXCL12(1), CXCR4(1), FOS(1), GNAQ(1), JUN(1), MAPK14(4), PLCG1(4), PRKCA(8), PTK2B(7), SYT1(12)	2781582	47	25	46	42	32	4	2	5	4	0	0.963	1.000	1.000
537	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(3), HS3ST1(8), HS3ST2(6), HS3ST3B1(2), XYLT1(8), XYLT2(2)	1274742	29	25	29	26	19	4	0	3	3	0	0.829	1.000	1.000
538	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(3), HS3ST1(8), HS3ST2(6), HS3ST3B1(2), XYLT1(8), XYLT2(2)	1274742	29	25	29	26	19	4	0	3	3	0	0.829	1.000	1.000
539	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(4), CAMK1G(9), HDAC9(27), MEF2A(2), MEF2B(2), MEF2C(2), MEF2D(2)	1482576	48	25	44	24	38	5	0	3	2	0	0.344	1.000	1.000
540	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(4), IFNAR1(1), IFNAR2(5), IFNB1(5), NFKB1(3), RELA(2), TNFRSF11A(5), TNFSF11(4), TRAF6(2)	2222303	32	25	31	21	24	2	0	2	4	0	0.840	1.000	1.000
541	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(14), EP300(8), HDAC3(3), IKBKB(2), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF6(2)	4479494	42	25	42	23	27	5	4	2	4	0	0.662	1.000	1.000
542	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAP3K14(1), MAPK14(4), NFKB1(3), RELA(2), TNFRSF13B(7), TNFRSF17(4), TRAF2(2), TRAF3(3), TRAF5(5), TRAF6(2)	2880747	34	25	34	21	25	3	0	4	2	0	0.745	1.000	1.000
543	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(15), GNA12(2), PRKACB(2), PRKACG(7), PRKAG1(2), PRKAR2A(1), PRKAR2B(4)	2027057	33	24	33	18	27	2	0	2	2	0	0.532	1.000	1.000
544	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(3), EGR1(1), HRAS(1), KLK2(1), MAP2K1(7), MAP2K2(2), MAPK1(3), MAPK3(1), NGFR(6), RAF1(2)	1624053	27	24	24	16	17	2	1	4	3	0	0.481	1.000	1.000
545	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(5), CDKN1A(2), EPO(4), EPOR(1), GRIN1(6), HIF1A(1), JAK2(6), NFKB1(3), NFKBIA(2), RELA(2)	2511853	32	24	32	18	15	4	4	3	6	0	0.713	1.000	1.000
546	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT1(3), FUT2(2), FUT9(14), GBGT1(1), GLA(1), HEXA(5), HEXB(2), NAGA(2), ST3GAL1(5), ST3GAL4(1)	2026877	39	24	38	22	28	3	0	6	2	0	0.363	1.000	1.000
547	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(4), CHST12(1), CHST13(2), PAPSS1(2), PAPSS2(4), SULT1A1(9), SULT1A2(2), SULT1E1(10), SULT2A1(4), SULT2B1(6), SUOX(3)	1824417	47	24	46	26	38	2	0	3	4	0	0.366	1.000	1.000
548	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), GRB2(2), IL2RG(2), IL4(1), IL4R(7), IRS1(3), JAK1(4), JAK3(5), RPS6KB1(2), SHC1(1), STAT6(5)	2957759	33	24	33	18	20	4	3	2	4	0	0.533	1.000	1.000
549	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(9), ARHGDIB(2), CASP1(3), CASP10(4), CASP3(1), CASP8(2), CASP9(3), CYCS(1), GZMB(2), JUN(1), PRF1(6)	2600944	37	23	37	19	26	4	2	4	1	0	0.563	1.000	1.000
550	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), ANKRD1(1), CYR61(1), DUSP14(1), IFNG(2), IL18(2), IL1A(3), IL1R1(7), MYOG(3), NR4A3(5), WDR1(2)	2129584	31	23	29	17	20	3	0	2	6	0	0.640	1.000	1.000
551	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), BLVRB(1), HMOX1(1), IL10(2), IL10RA(5), IL10RB(4), IL1A(3), JAK1(4), STAT1(2), STAT3(6), STAT5A(2), TNF(1)	2453531	32	23	32	17	17	3	4	3	5	0	0.371	1.000	1.000
552	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(5), GAD1(7), HDC(8), PNMT(4), TH(7), TPH1(2)	1195550	33	23	33	21	28	1	1	1	2	0	0.377	1.000	1.000
553	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(3), CREBBP(14), DFFA(1), DFFB(2), GZMA(10), GZMB(2), PRF1(6), SET(2)	2133167	40	23	39	16	24	3	5	3	5	0	0.315	1.000	1.000
554	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(4), CD8A(2), CSF1(8), CSF2(2), CSF3(2), EPO(4), IL11(2), IL2(4), IL3(2), IL4(1), IL5(4), IL7(3), IL8(1)	1213035	39	23	38	26	29	3	0	3	4	0	0.405	1.000	1.000
555	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(4), IKBKB(2), LTA(2), MAP3K14(1), NFKB1(3), NFKBIA(2), RELA(2), RIPK1(1), TNFAIP3(2), TNFRSF1B(1), TRAF1(6), TRAF2(2), TRAF3(3)	4470432	32	23	32	35	23	2	1	2	4	0	0.998	1.000	1.000
556	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), CD36(3), FOS(1), FYN(5), JUN(1), MAPK14(4), THBS1(19)	1488622	34	23	34	20	20	1	2	6	5	0	0.769	1.000	1.000
557	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(4), B3GNT1(2), FUT1(3), FUT2(2), FUT9(14)	1198591	25	22	25	14	19	3	1	2	0	0	0.355	1.000	1.000
558	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(5), DHRS1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(3), HSD3B7(1), PON1(12), PON2(1), PON3(4), RDH12(1), RDH13(3)	1818107	40	22	38	24	30	2	0	5	3	0	0.431	1.000	1.000
559	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(10), MBTPS1(3), SCAP(6), SREBF1(3), SREBF2(6)	2374923	29	22	28	19	20	2	2	2	3	0	0.688	1.000	1.000
560	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(2), IL4R(7), JAK1(4), JAK2(6), TYK2(4)	2097085	28	22	28	14	19	1	2	4	2	0	0.498	1.000	1.000
561	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(2), IL4R(7), JAK1(4), JAK2(6), TYK2(4)	2097085	28	22	28	14	19	1	2	4	2	0	0.498	1.000	1.000
562	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), GRB2(2), HRAS(1), KLK2(1), NTRK1(10), PIK3CA(2), PIK3R1(2), PLCG1(4), PRKCA(8), SHC1(1), SOS1(6)	3114639	38	22	37	23	27	5	1	3	2	0	0.758	1.000	1.000
563	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(17), GNAS(12), PRKACA(2), PRKAR1A(1)	1300906	32	21	32	15	21	2	2	3	4	0	0.299	1.000	1.000
564	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(6), CDO1(3), CSAD(3), GAD1(7), GAD2(4), GGT1(4)	1134318	27	21	26	17	19	2	1	4	1	0	0.600	1.000	1.000
565	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(4), B3GALT1(10), B3GALT2(1), B3GALT5(1), B3GNT5(1), FUT1(3), FUT2(2), FUT3(4), ST3GAL4(1)	1441134	27	21	27	24	21	2	0	2	2	0	0.885	1.000	1.000
566	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(2), ACO2(2), AFMID(1), CS(1), HAO1(5), HAO2(7), HYI(1), MDH1(1), MDH2(2), MTHFD1(7), MTHFD2(2)	2692199	31	21	30	21	20	1	4	3	3	0	0.722	1.000	1.000
567	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SEC22B(4), SNAP25(5), STX11(1), STX16(2), STX17(1), STX19(1), STX2(1), STX5(2), STX6(1), TSNARE1(2), VAMP3(1), VAMP4(1), VAMP7(2), VAMP8(1), VTI1A(1), VTI1B(1)	3318206	27	21	26	16	17	2	0	4	4	0	0.578	1.000	1.000
568	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(5), ADORA2A(2), ADORA2B(1), ADORA3(10), P2RY1(2), P2RY2(5), P2RY6(1)	1198176	26	21	26	24	17	5	0	2	2	0	0.500	1.000	1.000
569	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(5), CAPN1(1), CAPNS1(1), CDK5(3), CSNK1A1(2), CSNK1D(1), GSK3B(2), MAPT(7), PPP2CA(1)	1803693	23	21	23	12	14	1	1	2	5	0	0.545	1.000	1.000
570	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(12), CKM(2), GPT(3), LDHA(2), LDHC(3), MAPK14(4), NCL(4)	1805525	30	21	30	14	21	2	3	3	1	0	0.335	1.000	1.000
571	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(3), NRF1(4), UBE2D3(3), UBE2E1(1), UBE2I(2), UBE2J1(1), UBE2J2(3), UBE2L6(1), UBE2M(1), UBE2S(2), UBE3A(5)	2127504	26	21	25	11	19	5	0	2	0	0	0.368	1.000	1.000
572	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(6), FDPS(3), HMGCR(8), LSS(2), MVD(1), MVK(2), NQO1(1), PMVK(1), SC5DL(1), SQLE(2)	2211559	27	20	26	11	13	6	0	6	2	0	0.296	1.000	1.000
573	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(2), ACO2(2), CS(1), HAO1(5), HAO2(7), HYI(1), MDH1(1), MDH2(2), MTHFD1(7), MTHFD2(2)	2570721	30	20	29	17	20	1	3	3	3	0	0.508	1.000	1.000
574	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(10), HK1(1), HK2(5), HK3(10), IMPA1(1), IMPA2(2), ISYNA1(1), PGM1(2), PGM3(1), TGDS(1)	2337507	34	20	33	25	25	3	0	2	4	0	0.746	1.000	1.000
575	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(2), DHRS2(4), DHRS3(3), DHRS7(1), DHRSX(3), MYST3(10), MYST4(11), NAT6(2), PNPLA3(1), SH3GLB1(2)	3352608	39	20	38	31	25	5	1	6	2	0	0.989	1.000	1.000
576	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(3), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB7(1), PSMC3(2), PSMD14(1), RPN2(2), UBE3A(5)	2615652	25	20	25	11	15	4	1	3	2	0	0.464	1.000	1.000
577	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2)	1595261	26	19	26	14	15	4	1	2	4	0	0.357	1.000	1.000
578	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(9), ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2)	1595261	26	19	26	14	15	4	1	2	4	0	0.357	1.000	1.000
579	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(4), IKBKB(2), MAP3K14(1), NFKB1(3), NFKBIA(2), RELA(2), TNFAIP3(2), TRAF3(3), TRAF6(2)	3620731	22	19	22	24	15	2	1	2	2	0	0.995	1.000	1.000
580	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNAR2(5), IFNB1(5), JAK1(4), STAT1(2), STAT2(6), TYK2(4)	2163961	27	19	27	16	17	1	2	4	3	0	0.652	1.000	1.000
581	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(1), ESR1(2), GREB1(15), HSPB1(2), HSPB2(1), MTA1(1), MTA3(1), PDZK1(2), TUBA8(1)	2136360	27	19	26	16	18	2	2	3	2	0	0.497	1.000	1.000
582	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(6), CDC25B(3), CDC25C(3), CSK(1), GRB2(2), PRKCA(8), PTPRA(3), SRC(1)	1868520	27	18	26	17	18	5	1	1	2	0	0.665	1.000	1.000
583	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(10), HK1(1), HK2(5), HK3(10), IMPA1(1), PGM1(2), PGM3(1), TGDS(1)	2054995	31	18	30	21	24	3	0	1	3	0	0.652	1.000	1.000
584	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(4), CD80(3), HLA-DRA(7), HLA-DRB1(2), IL10(2), IL2(4), IL4(1)	791800	23	17	23	15	14	1	1	5	2	0	0.606	1.000	1.000
585	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(8), ENO1(2), GPI(2), HK1(1), PFKL(2), PGK1(2), PKLR(6)	1841319	23	17	22	14	17	1	1	1	3	0	0.317	1.000	1.000
586	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP2(3), MMP9(5), RECK(4), TIMP2(1), TIMP3(4), TIMP4(4)	1492444	22	17	22	11	12	1	2	6	1	0	0.557	1.000	1.000
587	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(6), JAK3(5), MAPK1(3), MAPK3(1), STAT3(6), TYK2(4)	2329397	29	17	29	25	18	3	3	3	2	0	0.931	1.000	1.000
588	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(6), ACO1(2), ACO2(2), ACSS2(3), FH(3), IDH1(7), MDH1(1), MDH2(2)	2692827	26	16	21	16	19	0	2	3	2	0	0.584	1.000	1.000
589	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(7), GOT1(4), GOT2(2), TAT(12), TYR(5)	946951	30	16	30	17	24	2	2	1	1	0	0.512	1.000	1.000
590	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(5), PLCG1(4), PRKCA(8), PTK2B(7)	1361174	24	16	23	18	20	2	0	0	2	0	0.619	1.000	1.000
591	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(1), B4GALT2(2), B4GALT3(2), B4GALT5(2), FUT8(5), ST3GAL1(5), ST3GAL4(1)	1578521	20	16	20	13	11	4	2	2	1	0	0.714	1.000	1.000
592	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(1), JUN(1), KEAP1(1), MAPK1(3), MAPK14(4), NFE2L2(1), PRKCA(8)	1779493	19	15	18	12	12	1	0	3	3	0	0.797	1.000	1.000
593	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(4), FUT1(3), FUT2(2), FUT3(4), FUT5(6), FUT6(1)	1003570	20	15	20	17	14	2	1	0	3	0	0.676	1.000	1.000
594	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(5), CLOCK(2), CRY1(3), CRY2(2), CSNK1E(3), PER1(4)	1692490	19	15	19	10	14	1	1	2	1	0	0.678	1.000	1.000
595	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(7), EIF2AK4(7), EIF2B5(1), EIF2S1(1), GSK3B(2), PPP1CA(1)	2343282	19	15	18	11	13	0	0	4	2	0	0.830	1.000	1.000
596	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(4), HMGCL(2), HMGCS1(1), HMGCS2(14), OXCT1(3), OXCT2(2)	1434917	27	15	26	14	19	3	0	3	2	0	0.587	1.000	1.000
597	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(2), CS(1), FH(3), MDH1(1), OGDH(8), SDHA(1)	1906980	16	15	15	11	11	0	2	0	3	0	0.827	1.000	1.000
598	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(8), IL1B(5), MST1(1), MST1R(5), TNF(1)	1316298	21	15	21	13	16	2	1	0	2	0	0.555	1.000	1.000
599	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(6), ADSS(1), MTHFD2(2), POLD1(3), POLG(4), PRPS2(1), RRM1(3)	2488954	20	15	20	14	11	2	1	3	3	0	0.788	1.000	1.000
600	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(4), ALDH3A2(2), ALDH7A1(3), ALDH9A1(2), MIOX(3)	1699457	20	14	20	15	12	3	2	0	3	0	0.736	1.000	1.000
601	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(2), ACO2(2), FH(3), IDH1(7), MDH1(1), MDH2(2)	1807183	17	14	12	10	12	0	2	2	1	0	0.623	1.000	1.000
602	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	11	ALAD(3), ALAS2(2), CPO(1), FECH(2), GATA1(1), HBB(5), HMBS(1), UROS(1)	1529810	16	13	15	10	13	1	0	0	2	0	0.525	1.000	1.000
603	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HRAS(1), PTK2B(7), SHC1(1), SOS1(6), SRC(1)	1766438	18	13	18	13	14	1	0	2	1	0	0.873	1.000	1.000
604	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(4), HGD(11)	452460	15	13	15	14	11	2	2	0	0	0	0.905	1.000	1.000
605	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(3), APOBEC2(3), APOBEC3A(1), APOBEC3B(1), APOBEC3C(2), APOBEC3F(1), APOBEC3G(1)	1487838	16	13	16	12	11	2	3	0	0	0	0.797	1.000	1.000
606	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), CSF1(8), LDLR(10), LPL(2)	1078788	21	13	21	14	17	3	1	0	0	0	0.593	1.000	1.000
607	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(4), HLA-DRA(7), HLA-DRB1(2)	473808	13	12	13	12	10	1	0	2	0	0	0.837	1.000	1.000
608	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(15), PSAT1(1)	978234	16	12	15	15	15	1	0	0	0	0	0.917	1.000	1.000
609	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(5), EPHX2(4), HSD3B7(1), RDH12(1), RDH13(3)	969697	14	11	14	11	11	0	1	0	2	0	0.666	1.000	1.000
610	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(2), COQ6(1), NDUFA12(1), NDUFA13(5)	799349	10	10	9	10	7	1	2	0	0	0	0.963	1.000	1.000
611	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(2), FURIN(2), NOTCH1(4), PSEN1(1)	1843128	10	10	10	13	6	2	1	1	0	0	0.971	1.000	1.000
612	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(5), CD3D(5), CD3E(2), CD4(4)	645504	16	10	16	19	11	2	0	2	1	0	0.960	1.000	1.000
613	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(3), AASDHPPT(1), AASS(1), KARS(3)	933736	8	8	8	5	7	0	0	1	0	0	0.807	1.000	1.000
614	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(5), ARG1(1), GLS(1), GLUD1(1), OAT(1), PRODH(1)	1089367	10	7	10	12	3	4	2	1	0	0	0.986	1.000	1.000
615	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(13)	367570	13	6	13	8	11	1	1	0	0	0	0.590	1.000	1.000
616	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2)	427553	2	2	2	4	1	0	0	1	0	0	0.984	1.000	1.000
