(primary solid tumor cohort)
This pipeline computes the correlation between cancer subtypes identified by different molecular patterns and selected clinical features.
Testing the association between subtypes identified by 8 different clustering approaches and 15 clinical features across 318 patients, 30 significant findings detected with P value < 0.05 and Q value < 0.25.
-
3 subtypes identified in current cancer cohort by 'Copy Number Ratio CNMF subtypes'. These subtypes correlate to 'AGE', 'HISTOLOGICAL.TYPE', and 'NEOPLASM.DISEASESTAGE'.
-
3 subtypes identified in current cancer cohort by 'METHLYATION CNMF'. These subtypes correlate to 'HISTOLOGICAL.TYPE', 'EXTRATHYROIDAL.EXTENSION', 'LYMPH.NODE.METASTASIS', 'NUMBER.OF.LYMPH.NODES', and 'NEOPLASM.DISEASESTAGE'.
-
CNMF clustering analysis on RPPA data identified 3 subtypes that correlate to 'AGE' and 'HISTOLOGICAL.TYPE'.
-
Consensus hierarchical clustering analysis on RPPA data identified 3 subtypes that correlate to 'AGE' and 'HISTOLOGICAL.TYPE'.
-
CNMF clustering analysis on sequencing-based mRNA expression data identified 4 subtypes that correlate to 'HISTOLOGICAL.TYPE', 'EXTRATHYROIDAL.EXTENSION', 'LYMPH.NODE.METASTASIS', and 'NUMBER.OF.LYMPH.NODES'.
-
Consensus hierarchical clustering analysis on sequencing-based mRNA expression data identified 3 subtypes that correlate to 'HISTOLOGICAL.TYPE', 'EXTRATHYROIDAL.EXTENSION', 'LYMPH.NODE.METASTASIS', and 'NUMBER.OF.LYMPH.NODES'.
-
3 subtypes identified in current cancer cohort by 'MIRSEQ CNMF'. These subtypes correlate to 'HISTOLOGICAL.TYPE', 'EXTRATHYROIDAL.EXTENSION', 'LYMPH.NODE.METASTASIS', 'NEOPLASM.DISEASESTAGE', and 'TUMOR.SIZE'.
-
3 subtypes identified in current cancer cohort by 'MIRSEQ CHIERARCHICAL'. These subtypes correlate to 'HISTOLOGICAL.TYPE', 'EXTRATHYROIDAL.EXTENSION', 'LYMPH.NODE.METASTASIS', 'NUMBER.OF.LYMPH.NODES', and 'NEOPLASM.DISEASESTAGE'.
Clinical Features |
Statistical Tests |
Copy Number Ratio CNMF subtypes |
METHLYATION CNMF |
RPPA CNMF subtypes |
RPPA cHierClus subtypes |
RNAseq CNMF subtypes |
RNAseq cHierClus subtypes |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
Time to Death | logrank test |
100 (1.00) |
100 (1.00) |
100 (1.00) |
100 (1.00) |
100 (1.00) |
100 (1.00) |
100 (1.00) |
100 (1.00) |
AGE | ANOVA |
0.00261 (0.216) |
0.0656 (1.00) |
0.000715 (0.0644) |
0.0011 (0.0944) |
0.0709 (1.00) |
0.076 (1.00) |
0.289 (1.00) |
0.0659 (1.00) |
GENDER | Fisher's exact test |
0.642 (1.00) |
0.873 (1.00) |
0.934 (1.00) |
0.535 (1.00) |
0.943 (1.00) |
0.51 (1.00) |
0.612 (1.00) |
0.527 (1.00) |
HISTOLOGICAL TYPE | Chi-square test |
0.00153 (0.13) |
1.46e-23 (1.59e-21) |
2.53e-10 (2.68e-08) |
1.76e-16 (1.88e-14) |
6.67e-27 (7.34e-25) |
2.52e-23 (2.72e-21) |
3.73e-30 (4.14e-28) |
7.64e-33 (8.55e-31) |
RADIATIONS RADIATION REGIMENINDICATION | Fisher's exact test |
0.394 (1.00) |
0.0789 (1.00) |
0.0118 (0.905) |
0.27 (1.00) |
0.00335 (0.274) |
0.0254 (1.00) |
0.311 (1.00) |
0.0468 (1.00) |
RADIATIONEXPOSURE | Fisher's exact test |
0.154 (1.00) |
0.732 (1.00) |
0.708 (1.00) |
0.084 (1.00) |
0.971 (1.00) |
1 (1.00) |
0.772 (1.00) |
0.634 (1.00) |
DISTANT METASTASIS | Chi-square test |
0.171 (1.00) |
0.584 (1.00) |
0.231 (1.00) |
0.369 (1.00) |
0.216 (1.00) |
0.864 (1.00) |
0.0149 (1.00) |
0.0249 (1.00) |
EXTRATHYROIDAL EXTENSION | Chi-square test |
0.259 (1.00) |
0.000265 (0.0247) |
0.0293 (1.00) |
0.104 (1.00) |
4.41e-05 (0.00428) |
0.0002 (0.019) |
3.82e-06 (0.000378) |
2.32e-05 (0.00227) |
LYMPH NODE METASTASIS | Chi-square test |
0.00666 (0.532) |
1.34e-07 (1.38e-05) |
0.187 (1.00) |
0.0143 (1.00) |
1.79e-07 (1.83e-05) |
1.59e-06 (0.000161) |
2.95e-08 (3.07e-06) |
2.5e-08 (2.62e-06) |
COMPLETENESS OF RESECTION | Chi-square test |
0.0911 (1.00) |
0.658 (1.00) |
0.639 (1.00) |
0.523 (1.00) |
0.591 (1.00) |
0.526 (1.00) |
0.666 (1.00) |
0.743 (1.00) |
NUMBER OF LYMPH NODES | ANOVA |
0.451 (1.00) |
0.000396 (0.0364) |
0.526 (1.00) |
0.316 (1.00) |
0.000232 (0.0218) |
0.00055 (0.05) |
0.00839 (0.663) |
0.000768 (0.0678) |
TUMOR STAGECODE | ANOVA | ||||||||
NEOPLASM DISEASESTAGE | Chi-square test |
2.65e-06 (0.000265) |
0.00256 (0.215) |
0.0303 (1.00) |
0.0414 (1.00) |
0.0222 (1.00) |
0.081 (1.00) |
0.000815 (0.0709) |
7.4e-05 (0.0071) |
MULTIFOCALITY | Fisher's exact test |
0.232 (1.00) |
0.342 (1.00) |
0.0105 (0.816) |
0.866 (1.00) |
0.0125 (0.947) |
0.0252 (1.00) |
0.815 (1.00) |
0.862 (1.00) |
TUMOR SIZE | ANOVA |
0.0816 (1.00) |
0.329 (1.00) |
0.659 (1.00) |
0.552 (1.00) |
0.0492 (1.00) |
0.168 (1.00) |
0.000762 (0.0678) |
0.00622 (0.504) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 22 | 234 | 47 |
P value = 100 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 303 | 1 | 0.0 - 66.2 (8.2) |
subtype1 | 22 | 1 | 0.4 - 65.9 (9.8) |
subtype2 | 234 | 0 | 0.1 - 66.2 (8.3) |
subtype3 | 47 | 0 | 0.0 - 65.9 (7.0) |
P value = 0.00261 (ANOVA), Q value = 0.22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 303 | 46.3 (15.4) |
subtype1 | 22 | 57.0 (12.9) |
subtype2 | 234 | 45.2 (15.8) |
subtype3 | 47 | 46.5 (12.6) |
P value = 0.642 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 227 | 76 |
subtype1 | 15 | 7 |
subtype2 | 175 | 59 |
subtype3 | 37 | 10 |
P value = 0.00153 (Chi-square test), Q value = 0.13
nPatients | OTHER | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 20 | 178 | 75 | 30 |
subtype1 | 5 | 10 | 7 | 0 |
subtype2 | 12 | 147 | 49 | 26 |
subtype3 | 3 | 21 | 19 | 4 |
P value = 0.394 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 14 | 289 |
subtype1 | 2 | 20 |
subtype2 | 11 | 223 |
subtype3 | 1 | 46 |
P value = 0.154 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 254 | 13 |
subtype1 | 19 | 2 |
subtype2 | 191 | 11 |
subtype3 | 44 | 0 |
P value = 0.171 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 141 | 4 | 157 |
subtype1 | 5 | 0 | 17 |
subtype2 | 114 | 3 | 116 |
subtype3 | 22 | 1 | 24 |
P value = 0.259 (Chi-square test), Q value = 1
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE |
---|---|---|---|
ALL | 69 | 6 | 214 |
subtype1 | 2 | 0 | 20 |
subtype2 | 57 | 6 | 159 |
subtype3 | 10 | 0 | 35 |
P value = 0.00666 (Chi-square test), Q value = 0.53
nPatients | N0 | N1 | N1A | N1B | NX |
---|---|---|---|---|---|
ALL | 148 | 17 | 65 | 42 | 31 |
subtype1 | 15 | 0 | 0 | 1 | 6 |
subtype2 | 107 | 16 | 56 | 32 | 23 |
subtype3 | 26 | 1 | 9 | 9 | 2 |
P value = 0.0911 (Chi-square test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 240 | 21 | 1 | 20 |
subtype1 | 18 | 0 | 0 | 4 |
subtype2 | 188 | 17 | 1 | 10 |
subtype3 | 34 | 4 | 0 | 6 |
P value = 0.451 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 242 | 2.8 (5.1) |
subtype1 | 14 | 1.1 (4.3) |
subtype2 | 189 | 2.9 (5.3) |
subtype3 | 39 | 2.6 (4.3) |
P value = 2.65e-06 (Chi-square test), Q value = 0.00027
nPatients | STAGE I | STAGE II | STAGE III | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|
ALL | 173 | 33 | 66 | 27 | 3 |
subtype1 | 5 | 11 | 5 | 1 | 0 |
subtype2 | 141 | 19 | 51 | 20 | 2 |
subtype3 | 27 | 3 | 10 | 6 | 1 |
P value = 0.232 (Fisher's exact test), Q value = 1
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 149 | 145 |
subtype1 | 10 | 12 |
subtype2 | 111 | 116 |
subtype3 | 28 | 17 |
P value = 0.0816 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 228 | 2.7 (1.5) |
subtype1 | 18 | 3.4 (1.4) |
subtype2 | 175 | 2.7 (1.4) |
subtype3 | 35 | 2.4 (1.7) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 101 | 46 | 171 |
P value = 100 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 318 | 1 | 0.0 - 66.2 (8.2) |
subtype1 | 101 | 1 | 0.0 - 66.1 (7.0) |
subtype2 | 46 | 0 | 0.1 - 66.2 (7.4) |
subtype3 | 171 | 0 | 0.2 - 66.1 (9.4) |
P value = 0.0656 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 318 | 46.3 (15.2) |
subtype1 | 101 | 49.0 (15.3) |
subtype2 | 46 | 43.2 (14.4) |
subtype3 | 171 | 45.6 (15.3) |
P value = 0.873 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 240 | 78 |
subtype1 | 78 | 23 |
subtype2 | 35 | 11 |
subtype3 | 127 | 44 |
P value = 1.46e-23 (Chi-square test), Q value = 1.6e-21
nPatients | OTHER | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 20 | 188 | 79 | 31 |
subtype1 | 15 | 26 | 58 | 2 |
subtype2 | 2 | 30 | 8 | 6 |
subtype3 | 3 | 132 | 13 | 23 |
P value = 0.0789 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 14 | 304 |
subtype1 | 1 | 100 |
subtype2 | 2 | 44 |
subtype3 | 11 | 160 |
P value = 0.732 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 265 | 13 |
subtype1 | 82 | 5 |
subtype2 | 39 | 2 |
subtype3 | 144 | 6 |
P value = 0.584 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 155 | 4 | 158 |
subtype1 | 43 | 2 | 55 |
subtype2 | 24 | 0 | 22 |
subtype3 | 88 | 2 | 81 |
P value = 0.000265 (Chi-square test), Q value = 0.025
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE |
---|---|---|---|
ALL | 70 | 6 | 226 |
subtype1 | 10 | 0 | 85 |
subtype2 | 9 | 0 | 35 |
subtype3 | 51 | 6 | 106 |
P value = 1.34e-07 (Chi-square test), Q value = 1.4e-05
nPatients | N0 | N1 | N1A | N1B | NX |
---|---|---|---|---|---|
ALL | 157 | 20 | 67 | 43 | 31 |
subtype1 | 72 | 2 | 7 | 5 | 15 |
subtype2 | 21 | 2 | 13 | 8 | 2 |
subtype3 | 64 | 16 | 47 | 30 | 14 |
P value = 0.658 (Chi-square test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 251 | 24 | 1 | 21 |
subtype1 | 83 | 4 | 0 | 7 |
subtype2 | 34 | 4 | 0 | 4 |
subtype3 | 134 | 16 | 1 | 10 |
P value = 0.000396 (ANOVA), Q value = 0.036
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 255 | 2.7 (5.0) |
subtype1 | 71 | 0.8 (2.2) |
subtype2 | 41 | 2.6 (4.2) |
subtype3 | 143 | 3.7 (5.9) |
P value = 0.00256 (Chi-square test), Q value = 0.22
nPatients | STAGE I | STAGE II | STAGE III | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|
ALL | 183 | 35 | 68 | 28 | 3 |
subtype1 | 56 | 21 | 19 | 2 | 2 |
subtype2 | 29 | 3 | 9 | 5 | 0 |
subtype3 | 98 | 11 | 40 | 21 | 1 |
P value = 0.342 (Fisher's exact test), Q value = 1
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 152 | 157 |
subtype1 | 45 | 54 |
subtype2 | 19 | 25 |
subtype3 | 88 | 78 |
P value = 0.329 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 241 | 2.7 (1.5) |
subtype1 | 77 | 2.9 (1.7) |
subtype2 | 32 | 2.5 (1.2) |
subtype3 | 132 | 2.6 (1.4) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 46 | 59 | 59 |
P value = 100 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 164 | 1 | 0.1 - 66.1 (8.5) |
subtype1 | 46 | 0 | 0.3 - 50.5 (8.3) |
subtype2 | 59 | 0 | 0.2 - 65.9 (9.3) |
subtype3 | 59 | 1 | 0.1 - 66.1 (7.7) |
P value = 0.000715 (ANOVA), Q value = 0.064
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 164 | 46.8 (16.1) |
subtype1 | 46 | 50.0 (13.9) |
subtype2 | 59 | 50.5 (16.0) |
subtype3 | 59 | 40.5 (16.1) |
P value = 0.934 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 111 | 53 |
subtype1 | 31 | 15 |
subtype2 | 41 | 18 |
subtype3 | 39 | 20 |
P value = 2.53e-10 (Chi-square test), Q value = 2.7e-08
nPatients | OTHER | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 13 | 84 | 53 | 14 |
subtype1 | 1 | 12 | 31 | 2 |
subtype2 | 10 | 30 | 8 | 11 |
subtype3 | 2 | 42 | 14 | 1 |
P value = 0.0118 (Fisher's exact test), Q value = 0.91
nPatients | NO | YES |
---|---|---|
ALL | 13 | 151 |
subtype1 | 0 | 46 |
subtype2 | 9 | 50 |
subtype3 | 4 | 55 |
P value = 0.708 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 138 | 7 |
subtype1 | 41 | 1 |
subtype2 | 49 | 3 |
subtype3 | 48 | 3 |
P value = 0.231 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 71 | 2 | 90 |
subtype1 | 25 | 1 | 19 |
subtype2 | 25 | 0 | 34 |
subtype3 | 21 | 1 | 37 |
P value = 0.0293 (Chi-square test), Q value = 1
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE |
---|---|---|---|
ALL | 33 | 3 | 120 |
subtype1 | 8 | 0 | 38 |
subtype2 | 17 | 3 | 36 |
subtype3 | 8 | 0 | 46 |
P value = 0.187 (Chi-square test), Q value = 1
nPatients | N0 | N1 | N1A | N1B | NX |
---|---|---|---|---|---|
ALL | 76 | 11 | 33 | 21 | 23 |
subtype1 | 29 | 0 | 7 | 4 | 6 |
subtype2 | 24 | 6 | 11 | 10 | 8 |
subtype3 | 23 | 5 | 15 | 7 | 9 |
P value = 0.639 (Chi-square test), Q value = 1
nPatients | R0 | R1 | RX |
---|---|---|---|
ALL | 129 | 11 | 10 |
subtype1 | 38 | 3 | 4 |
subtype2 | 45 | 6 | 3 |
subtype3 | 46 | 2 | 3 |
P value = 0.526 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 124 | 3.0 (5.6) |
subtype1 | 32 | 2.4 (6.1) |
subtype2 | 48 | 2.7 (4.6) |
subtype3 | 44 | 3.8 (6.4) |
P value = 0.0303 (Chi-square test), Q value = 1
nPatients | STAGE I | STAGE II | STAGE III | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|
ALL | 86 | 28 | 34 | 13 | 2 |
subtype1 | 24 | 9 | 10 | 1 | 1 |
subtype2 | 22 | 12 | 16 | 9 | 0 |
subtype3 | 40 | 7 | 8 | 3 | 1 |
P value = 0.0105 (Fisher's exact test), Q value = 0.82
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 77 | 79 |
subtype1 | 28 | 15 |
subtype2 | 20 | 37 |
subtype3 | 29 | 27 |
P value = 0.659 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 141 | 3.1 (1.6) |
subtype1 | 41 | 3.0 (1.5) |
subtype2 | 51 | 3.2 (1.7) |
subtype3 | 49 | 3.0 (1.5) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 70 | 26 | 68 |
P value = 100 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 164 | 1 | 0.1 - 66.1 (8.5) |
subtype1 | 70 | 1 | 0.3 - 65.9 (8.0) |
subtype2 | 26 | 0 | 1.1 - 65.9 (9.0) |
subtype3 | 68 | 0 | 0.1 - 66.1 (9.2) |
P value = 0.0011 (ANOVA), Q value = 0.094
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 164 | 46.8 (16.1) |
subtype1 | 70 | 49.1 (15.7) |
subtype2 | 26 | 53.8 (15.9) |
subtype3 | 68 | 41.7 (15.3) |
P value = 0.535 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 111 | 53 |
subtype1 | 44 | 26 |
subtype2 | 19 | 7 |
subtype3 | 48 | 20 |
P value = 1.76e-16 (Chi-square test), Q value = 1.9e-14
nPatients | OTHER | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 13 | 84 | 53 | 14 |
subtype1 | 0 | 24 | 42 | 4 |
subtype2 | 10 | 8 | 7 | 1 |
subtype3 | 3 | 52 | 4 | 9 |
P value = 0.27 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 13 | 151 |
subtype1 | 3 | 67 |
subtype2 | 2 | 24 |
subtype3 | 8 | 60 |
P value = 0.084 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 138 | 7 |
subtype1 | 63 | 1 |
subtype2 | 22 | 3 |
subtype3 | 53 | 3 |
P value = 0.369 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 71 | 2 | 90 |
subtype1 | 29 | 2 | 38 |
subtype2 | 9 | 0 | 17 |
subtype3 | 33 | 0 | 35 |
P value = 0.104 (Chi-square test), Q value = 1
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE |
---|---|---|---|
ALL | 33 | 3 | 120 |
subtype1 | 11 | 0 | 57 |
subtype2 | 5 | 0 | 21 |
subtype3 | 17 | 3 | 42 |
P value = 0.0143 (Chi-square test), Q value = 1
nPatients | N0 | N1 | N1A | N1B | NX |
---|---|---|---|---|---|
ALL | 76 | 11 | 33 | 21 | 23 |
subtype1 | 42 | 2 | 10 | 6 | 10 |
subtype2 | 12 | 1 | 3 | 4 | 6 |
subtype3 | 22 | 8 | 20 | 11 | 7 |
P value = 0.523 (Chi-square test), Q value = 1
nPatients | R0 | R1 | RX |
---|---|---|---|
ALL | 129 | 11 | 10 |
subtype1 | 57 | 4 | 5 |
subtype2 | 22 | 1 | 3 |
subtype3 | 50 | 6 | 2 |
P value = 0.316 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 124 | 3.0 (5.6) |
subtype1 | 51 | 2.1 (5.2) |
subtype2 | 21 | 3.1 (5.8) |
subtype3 | 52 | 3.8 (6.0) |
P value = 0.0414 (Chi-square test), Q value = 1
nPatients | STAGE I | STAGE II | STAGE III | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|
ALL | 86 | 28 | 34 | 13 | 2 |
subtype1 | 38 | 12 | 15 | 2 | 2 |
subtype2 | 7 | 8 | 7 | 4 | 0 |
subtype3 | 41 | 8 | 12 | 7 | 0 |
P value = 0.866 (Fisher's exact test), Q value = 1
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 77 | 79 |
subtype1 | 34 | 33 |
subtype2 | 11 | 14 |
subtype3 | 32 | 32 |
P value = 0.552 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 141 | 3.1 (1.6) |
subtype1 | 62 | 3.0 (1.5) |
subtype2 | 21 | 3.4 (2.0) |
subtype3 | 58 | 3.0 (1.4) |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 95 | 32 | 70 | 92 |
P value = 100 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 289 | 1 | 0.0 - 66.2 (8.2) |
subtype1 | 95 | 1 | 0.0 - 65.9 (6.9) |
subtype2 | 32 | 0 | 0.1 - 66.2 (5.9) |
subtype3 | 70 | 0 | 0.2 - 66.1 (10.1) |
subtype4 | 92 | 0 | 0.2 - 66.2 (9.4) |
P value = 0.0709 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 289 | 46.7 (15.5) |
subtype1 | 95 | 49.7 (15.5) |
subtype2 | 32 | 44.0 (13.7) |
subtype3 | 70 | 43.8 (14.0) |
subtype4 | 92 | 46.6 (16.6) |
P value = 0.943 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 216 | 73 |
subtype1 | 72 | 23 |
subtype2 | 25 | 7 |
subtype3 | 52 | 18 |
subtype4 | 67 | 25 |
P value = 6.67e-27 (Chi-square test), Q value = 7.3e-25
nPatients | OTHER | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 18 | 169 | 73 | 29 |
subtype1 | 14 | 21 | 58 | 2 |
subtype2 | 1 | 23 | 3 | 5 |
subtype3 | 1 | 58 | 9 | 2 |
subtype4 | 2 | 67 | 3 | 20 |
P value = 0.00335 (Fisher's exact test), Q value = 0.27
nPatients | NO | YES |
---|---|---|
ALL | 12 | 277 |
subtype1 | 1 | 94 |
subtype2 | 0 | 32 |
subtype3 | 1 | 69 |
subtype4 | 10 | 82 |
P value = 0.971 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 241 | 12 |
subtype1 | 80 | 5 |
subtype2 | 25 | 1 |
subtype3 | 58 | 3 |
subtype4 | 78 | 3 |
P value = 0.216 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 140 | 4 | 144 |
subtype1 | 37 | 2 | 55 |
subtype2 | 21 | 0 | 11 |
subtype3 | 38 | 1 | 31 |
subtype4 | 44 | 1 | 47 |
P value = 4.41e-05 (Chi-square test), Q value = 0.0043
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE |
---|---|---|---|
ALL | 67 | 5 | 203 |
subtype1 | 10 | 0 | 81 |
subtype2 | 8 | 0 | 22 |
subtype3 | 17 | 0 | 51 |
subtype4 | 32 | 5 | 49 |
P value = 1.79e-07 (Chi-square test), Q value = 1.8e-05
nPatients | N0 | N1 | N1A | N1B | NX |
---|---|---|---|---|---|
ALL | 145 | 16 | 58 | 42 | 28 |
subtype1 | 69 | 0 | 7 | 5 | 14 |
subtype2 | 14 | 1 | 10 | 7 | 0 |
subtype3 | 29 | 4 | 20 | 13 | 4 |
subtype4 | 33 | 11 | 21 | 17 | 10 |
P value = 0.591 (Chi-square test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 229 | 18 | 1 | 20 |
subtype1 | 78 | 4 | 0 | 7 |
subtype2 | 22 | 2 | 0 | 4 |
subtype3 | 57 | 4 | 1 | 3 |
subtype4 | 72 | 8 | 0 | 6 |
P value = 0.000232 (ANOVA), Q value = 0.022
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 229 | 2.8 (5.2) |
subtype1 | 69 | 0.7 (2.1) |
subtype2 | 29 | 4.1 (6.0) |
subtype3 | 57 | 4.5 (7.0) |
subtype4 | 74 | 3.0 (4.7) |
P value = 0.0222 (Chi-square test), Q value = 1
nPatients | STAGE I | STAGE II | STAGE III | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|
ALL | 163 | 34 | 62 | 26 | 3 |
subtype1 | 51 | 19 | 20 | 2 | 2 |
subtype2 | 22 | 2 | 5 | 3 | 0 |
subtype3 | 42 | 8 | 12 | 8 | 0 |
subtype4 | 48 | 5 | 25 | 13 | 1 |
P value = 0.0125 (Fisher's exact test), Q value = 0.95
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 143 | 137 |
subtype1 | 47 | 46 |
subtype2 | 14 | 16 |
subtype3 | 45 | 22 |
subtype4 | 37 | 53 |
P value = 0.0492 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 217 | 2.7 (1.5) |
subtype1 | 72 | 2.9 (1.7) |
subtype2 | 19 | 1.9 (1.1) |
subtype3 | 53 | 2.5 (1.4) |
subtype4 | 73 | 2.7 (1.3) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 105 | 128 | 56 |
P value = 100 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 289 | 1 | 0.0 - 66.2 (8.2) |
subtype1 | 105 | 1 | 0.0 - 66.2 (6.9) |
subtype2 | 128 | 0 | 0.2 - 66.2 (9.2) |
subtype3 | 56 | 0 | 0.2 - 66.1 (10.1) |
P value = 0.076 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 289 | 46.7 (15.5) |
subtype1 | 105 | 49.2 (15.0) |
subtype2 | 128 | 45.8 (15.8) |
subtype3 | 56 | 43.8 (15.2) |
P value = 0.51 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 216 | 73 |
subtype1 | 79 | 26 |
subtype2 | 92 | 36 |
subtype3 | 45 | 11 |
P value = 2.52e-23 (Chi-square test), Q value = 2.7e-21
nPatients | OTHER | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 18 | 169 | 73 | 29 |
subtype1 | 14 | 29 | 58 | 4 |
subtype2 | 4 | 93 | 7 | 24 |
subtype3 | 0 | 47 | 8 | 1 |
P value = 0.0254 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 12 | 277 |
subtype1 | 1 | 104 |
subtype2 | 10 | 118 |
subtype3 | 1 | 55 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 241 | 12 |
subtype1 | 87 | 4 |
subtype2 | 106 | 6 |
subtype3 | 48 | 2 |
P value = 0.864 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 140 | 4 | 144 |
subtype1 | 47 | 2 | 55 |
subtype2 | 65 | 1 | 62 |
subtype3 | 28 | 1 | 27 |
P value = 2e-04 (Chi-square test), Q value = 0.019
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE |
---|---|---|---|
ALL | 67 | 5 | 203 |
subtype1 | 13 | 0 | 86 |
subtype2 | 42 | 5 | 74 |
subtype3 | 12 | 0 | 43 |
P value = 1.59e-06 (Chi-square test), Q value = 0.00016
nPatients | N0 | N1 | N1A | N1B | NX |
---|---|---|---|---|---|
ALL | 145 | 16 | 58 | 42 | 28 |
subtype1 | 73 | 1 | 9 | 8 | 14 |
subtype2 | 45 | 12 | 38 | 23 | 10 |
subtype3 | 27 | 3 | 11 | 11 | 4 |
P value = 0.526 (Chi-square test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 229 | 18 | 1 | 20 |
subtype1 | 85 | 5 | 0 | 7 |
subtype2 | 99 | 10 | 0 | 9 |
subtype3 | 45 | 3 | 1 | 4 |
P value = 0.00055 (ANOVA), Q value = 0.05
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 229 | 2.8 (5.2) |
subtype1 | 76 | 1.0 (3.3) |
subtype2 | 108 | 3.4 (4.9) |
subtype3 | 45 | 4.5 (7.4) |
P value = 0.081 (Chi-square test), Q value = 1
nPatients | STAGE I | STAGE II | STAGE III | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|
ALL | 163 | 34 | 62 | 26 | 3 |
subtype1 | 57 | 19 | 22 | 4 | 2 |
subtype2 | 74 | 8 | 30 | 15 | 1 |
subtype3 | 32 | 7 | 10 | 7 | 0 |
P value = 0.0252 (Fisher's exact test), Q value = 1
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 143 | 137 |
subtype1 | 51 | 50 |
subtype2 | 56 | 69 |
subtype3 | 36 | 18 |
P value = 0.168 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 217 | 2.7 (1.5) |
subtype1 | 78 | 2.9 (1.7) |
subtype2 | 97 | 2.5 (1.3) |
subtype3 | 42 | 2.5 (1.4) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 90 | 109 | 101 |
P value = 100 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 300 | 1 | 0.0 - 66.2 (8.2) |
subtype1 | 90 | 1 | 0.3 - 65.9 (7.2) |
subtype2 | 109 | 0 | 0.2 - 66.2 (9.8) |
subtype3 | 101 | 0 | 0.0 - 66.2 (8.0) |
P value = 0.289 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 300 | 46.5 (15.3) |
subtype1 | 90 | 48.4 (16.2) |
subtype2 | 109 | 44.9 (15.4) |
subtype3 | 101 | 46.7 (14.4) |
P value = 0.612 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 223 | 77 |
subtype1 | 64 | 26 |
subtype2 | 81 | 28 |
subtype3 | 78 | 23 |
P value = 3.73e-30 (Chi-square test), Q value = 4.1e-28
nPatients | OTHER | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 20 | 172 | 78 | 30 |
subtype1 | 15 | 16 | 59 | 0 |
subtype2 | 2 | 85 | 12 | 10 |
subtype3 | 3 | 71 | 7 | 20 |
P value = 0.311 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 14 | 286 |
subtype1 | 3 | 87 |
subtype2 | 8 | 101 |
subtype3 | 3 | 98 |
P value = 0.772 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 251 | 13 |
subtype1 | 78 | 3 |
subtype2 | 87 | 6 |
subtype3 | 86 | 4 |
P value = 0.0149 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 137 | 4 | 158 |
subtype1 | 31 | 2 | 56 |
subtype2 | 47 | 2 | 60 |
subtype3 | 59 | 0 | 42 |
P value = 3.82e-06 (Chi-square test), Q value = 0.00038
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE |
---|---|---|---|
ALL | 68 | 6 | 212 |
subtype1 | 6 | 0 | 81 |
subtype2 | 27 | 1 | 73 |
subtype3 | 35 | 5 | 58 |
P value = 2.95e-08 (Chi-square test), Q value = 3.1e-06
nPatients | N0 | N1 | N1A | N1B | NX |
---|---|---|---|---|---|
ALL | 148 | 17 | 64 | 41 | 30 |
subtype1 | 61 | 1 | 5 | 6 | 17 |
subtype2 | 47 | 10 | 31 | 12 | 9 |
subtype3 | 40 | 6 | 28 | 23 | 4 |
P value = 0.666 (Chi-square test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 238 | 21 | 1 | 19 |
subtype1 | 73 | 5 | 0 | 8 |
subtype2 | 83 | 8 | 1 | 7 |
subtype3 | 82 | 8 | 0 | 4 |
P value = 0.00839 (ANOVA), Q value = 0.66
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 239 | 2.8 (5.1) |
subtype1 | 63 | 1.2 (3.1) |
subtype2 | 92 | 2.8 (5.5) |
subtype3 | 84 | 3.9 (5.6) |
P value = 0.000815 (Chi-square test), Q value = 0.071
nPatients | STAGE I | STAGE II | STAGE III | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|
ALL | 169 | 35 | 66 | 26 | 3 |
subtype1 | 50 | 19 | 15 | 3 | 2 |
subtype2 | 68 | 11 | 21 | 8 | 1 |
subtype3 | 51 | 5 | 30 | 15 | 0 |
P value = 0.815 (Fisher's exact test), Q value = 1
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 148 | 143 |
subtype1 | 42 | 45 |
subtype2 | 53 | 51 |
subtype3 | 53 | 47 |
P value = 0.000762 (ANOVA), Q value = 0.068
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 229 | 2.7 (1.5) |
subtype1 | 72 | 3.1 (1.6) |
subtype2 | 86 | 2.7 (1.4) |
subtype3 | 71 | 2.2 (1.3) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 83 | 115 | 102 |
P value = 100 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 300 | 1 | 0.0 - 66.2 (8.2) |
subtype1 | 83 | 1 | 0.3 - 65.9 (7.1) |
subtype2 | 115 | 0 | 0.0 - 66.2 (8.0) |
subtype3 | 102 | 0 | 0.2 - 66.1 (9.9) |
P value = 0.0659 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 300 | 46.5 (15.3) |
subtype1 | 83 | 49.4 (15.5) |
subtype2 | 115 | 46.7 (15.0) |
subtype3 | 102 | 44.1 (15.4) |
P value = 0.527 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 223 | 77 |
subtype1 | 62 | 21 |
subtype2 | 89 | 26 |
subtype3 | 72 | 30 |
P value = 7.64e-33 (Chi-square test), Q value = 8.6e-31
nPatients | OTHER | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 20 | 172 | 78 | 30 |
subtype1 | 15 | 12 | 56 | 0 |
subtype2 | 3 | 80 | 7 | 25 |
subtype3 | 2 | 80 | 15 | 5 |
P value = 0.0468 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 14 | 286 |
subtype1 | 1 | 82 |
subtype2 | 4 | 111 |
subtype3 | 9 | 93 |
P value = 0.634 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 251 | 13 |
subtype1 | 72 | 3 |
subtype2 | 98 | 4 |
subtype3 | 81 | 6 |
P value = 0.0249 (Chi-square test), Q value = 1
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 137 | 4 | 158 |
subtype1 | 29 | 2 | 51 |
subtype2 | 65 | 0 | 50 |
subtype3 | 43 | 2 | 57 |
P value = 2.32e-05 (Chi-square test), Q value = 0.0023
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE |
---|---|---|---|
ALL | 68 | 6 | 212 |
subtype1 | 6 | 0 | 74 |
subtype2 | 39 | 5 | 67 |
subtype3 | 23 | 1 | 71 |
P value = 2.5e-08 (Chi-square test), Q value = 2.6e-06
nPatients | N0 | N1 | N1A | N1B | NX |
---|---|---|---|---|---|
ALL | 148 | 17 | 64 | 41 | 30 |
subtype1 | 60 | 0 | 3 | 5 | 15 |
subtype2 | 44 | 9 | 33 | 23 | 6 |
subtype3 | 44 | 8 | 28 | 13 | 9 |
P value = 0.743 (Chi-square test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 238 | 21 | 1 | 19 |
subtype1 | 69 | 4 | 0 | 6 |
subtype2 | 90 | 10 | 0 | 6 |
subtype3 | 79 | 7 | 1 | 7 |
P value = 0.000768 (ANOVA), Q value = 0.068
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 239 | 2.8 (5.1) |
subtype1 | 59 | 0.9 (2.7) |
subtype2 | 94 | 4.1 (6.3) |
subtype3 | 86 | 2.6 (4.5) |
P value = 7.4e-05 (Chi-square test), Q value = 0.0071
nPatients | STAGE I | STAGE II | STAGE III | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|
ALL | 169 | 35 | 66 | 26 | 3 |
subtype1 | 44 | 19 | 15 | 2 | 2 |
subtype2 | 58 | 6 | 36 | 15 | 0 |
subtype3 | 67 | 10 | 15 | 9 | 1 |
P value = 0.862 (Fisher's exact test), Q value = 1
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 148 | 143 |
subtype1 | 40 | 42 |
subtype2 | 57 | 56 |
subtype3 | 51 | 45 |
P value = 0.00622 (ANOVA), Q value = 0.5
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 229 | 2.7 (1.5) |
subtype1 | 68 | 3.1 (1.7) |
subtype2 | 85 | 2.3 (1.3) |
subtype3 | 76 | 2.7 (1.4) |
-
Cluster data file = THCA-TP.mergedcluster.txt
-
Clinical data file = THCA-TP.clin.merged.picked.txt
-
Number of patients = 318
-
Number of clustering approaches = 8
-
Number of selected clinical features = 15
-
Exclude small clusters that include fewer than K patients, K = 3
consensus non-negative matrix factorization clustering approach (Brunet et al. 2004)
Resampling-based clustering method (Monti et al. 2003)
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For continuous numerical clinical features, one-way analysis of variance (Howell 2002) was applied to compare the clinical values between tumor subtypes using 'anova' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.