BMP receptor signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BMP7/BMPR2/BMPR1A-1B/FS 0.064 0.079 -9999.0 0.0 -0.316 2.0 2.0 SMAD6-7/SMURF1 0.042 0.061 -9999.0 0.0 -0.365 1.0 1.0 NOG -0.051 0.196 -9999.0 0.0 -0.576 6.0 6.0 SMAD9 -0.017 0.144 -9999.0 0.0 -0.442 5.0 5.0 SMAD4 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SMAD5 0.016 0.044 -9999.0 0.0 -9999.0 0.0 0.0 BMP7/USAG1 -0.088 0.175 -9999.0 0.0 -0.402 10.0 10.0 SMAD5/SKI 0.032 0.049 -9999.0 0.0 -9999.0 0.0 0.0 SMAD1 -0.052 0.089 -9999.0 0.0 -9999.0 0.0 0.0 BMP2 0.017 0.043 -9999.0 0.0 -0.192 2.0 2.0 SMAD1/SMAD1/SMAD4 -0.04 0.091 -9999.0 0.0 -9999.0 0.0 0.0 BMPR1A 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BMPR1B -0.003 0.098 -9999.0 0.0 -0.288 4.0 4.0 BMPR1A-1B/BAMBI 0.015 0.082 -9999.0 0.0 -0.365 1.0 1.0 AHSG -0.039 0.133 -9999.0 0.0 -0.277 9.0 9.0 CER1 -0.017 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/CER1 0.036 0.034 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA 0.031 0.062 -9999.0 0.0 -0.289 1.0 1.0 BMP2-4 (homodimer) 0.031 0.034 -9999.0 0.0 -9999.0 0.0 0.0 RGMB 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BMP6/BMPR2/BMPR1A-1B 0.049 0.068 -9999.0 0.0 -0.334 1.0 1.0 RGMA 0.01 0.09 -9999.0 0.0 -0.576 1.0 1.0 SMURF1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP 0.011 0.065 -9999.0 0.0 -0.292 2.0 2.0 BMP2-4/USAG1 -0.06 0.153 -9999.0 0.0 -0.346 9.0 9.0 SMAD6/SMURF1/SMAD5 0.032 0.049 -9999.0 0.0 -9999.0 0.0 0.0 SOSTDC1 -0.145 0.235 -9999.0 0.0 -0.375 21.0 21.0 BMP7/BMPR2/BMPR1A-1B 0.049 0.068 -9999.0 0.0 -0.334 1.0 1.0 SKI 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BMP6 (homodimer) 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HFE2 -0.011 0.043 -9999.0 0.0 -0.192 2.0 2.0 ZFYVE16 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/CHRD 0.021 0.091 -9999.0 0.0 -0.365 2.0 2.0 SMAD5/SMAD5/SMAD4 0.029 0.046 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.014 0.013 -9999.0 0.0 -9999.0 0.0 0.0 TAK1/TAB family 0.03 0.062 -9999.0 0.0 -0.255 2.0 2.0 BMP7 (homodimer) 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NUP214 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BMP6/FETUA -0.005 0.104 -9999.0 0.0 -0.425 2.0 2.0 SMAD1/SKI -0.041 0.093 -9999.0 0.0 -9999.0 0.0 0.0 SMAD6 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTDSP2 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/FETUA 0.003 0.097 -9999.0 0.0 -0.365 2.0 2.0 MAP3K7IP1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GREM1 -0.081 0.2 -9999.0 0.0 -0.369 13.0 13.0 BMPR2 (homodimer) 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GADD34/PP1CA 0.043 0.022 -9999.0 0.0 -9999.0 0.0 0.0 BMPR1A-1B (homodimer) 0.019 0.075 -9999.0 0.0 -0.425 1.0 1.0 CHRDL1 -0.135 0.215 -9999.0 0.0 -0.576 8.0 8.0 ENDOFIN/SMAD1 -0.043 0.094 -9999.0 0.0 -9999.0 0.0 0.0 SMAD6-7/SMURF1/SMAD1 -0.036 0.104 -9999.0 0.0 -9999.0 0.0 0.0 SMAD6/SMURF1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BAMBI -0.001 0.072 -9999.0 0.0 -0.192 6.0 6.0 SMURF2 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/CHRDL1 -0.066 0.15 -9999.0 0.0 -0.365 8.0 8.0 BMP2-4/GREM1 -0.021 0.131 -9999.0 0.0 -0.365 5.0 5.0 SMAD7 0.013 0.085 -9999.0 0.0 -0.576 1.0 1.0 SMAD8A/SMAD8A/SMAD4 -0.004 0.141 -9999.0 0.0 -0.417 5.0 5.0 SMAD1/SMAD6 -0.041 0.093 -9999.0 0.0 -9999.0 0.0 0.0 TAK1/SMAD6 0.039 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BMP7 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BMP6 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7IP2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 0.019 0.051 -9999.0 0.0 -9999.0 0.0 0.0 PPM1A 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SMAD1/SMURF2 -0.039 0.087 -9999.0 0.0 -9999.0 0.0 0.0 SMAD7/SMURF1 0.027 0.066 -9999.0 0.0 -0.425 1.0 1.0 CTDSPL 0.022 0.031 -9999.0 0.0 -0.192 1.0 1.0 PPP1CA 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 XIAP 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTDSP1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PPP1R15A 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/FS 0.009 0.056 -9999.0 0.0 -9999.0 0.0 0.0 CHRD -0.007 0.125 -9999.0 0.0 -0.384 4.0 4.0 BMPR2 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM 0.014 0.047 -9999.0 0.0 -9999.0 0.0 0.0 BMP4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 FST -0.016 0.108 -9999.0 0.0 -0.576 1.0 1.0 BMP2-4/NOG -0.01 0.141 -9999.0 0.0 -0.379 6.0 6.0 BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 0.069 0.058 -9999.0 0.0 -0.316 1.0 1.0