Ceramide signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations SPHK2 0.013 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MAP4K4 -0.008 0.073 -9999.0 0.0 -9999.0 0.0 0.0 BAG4 -0.022 0.165 -9999.0 0.0 -0.576 4.0 4.0 PKC zeta/ceramide -0.013 0.08 -9999.0 0.0 -0.216 6.0 6.0 NFKBIA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BIRC3 0.012 0.052 -9999.0 0.0 -0.192 3.0 3.0 BAX -0.006 0.055 -9999.0 0.0 -0.341 1.0 1.0 RIPK1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.029 0.153 0.76 2.0 -9999.0 0.0 2.0 BAD -0.028 0.077 0.193 1.0 -0.198 7.0 8.0 SMPD1 -0.026 0.078 -9999.0 0.0 -0.197 8.0 8.0 RB1 -0.029 0.063 -9999.0 0.0 -0.187 6.0 6.0 FADD/Caspase 8 -0.0 0.071 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K4 0.001 0.076 0.179 3.0 -9999.0 0.0 3.0 NSMAF 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to UV 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAF1 -0.001 0.085 0.178 3.0 -9999.0 0.0 3.0 EGF 0.006 0.094 -9999.0 0.0 -0.576 1.0 1.0 mol:ceramide -0.031 0.075 -9999.0 0.0 -0.212 7.0 7.0 MADD 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 response to oxidative stress 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Free Fatty acid 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ASAH1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 negative regulation of cell cycle -0.029 0.062 -9999.0 0.0 -0.185 6.0 6.0 cell proliferation -0.005 0.114 -9999.0 0.0 -0.266 5.0 5.0 BID -0.258 0.317 -9999.0 0.0 -0.606 21.0 21.0 MAP3K1 -0.027 0.062 -9999.0 0.0 -0.187 6.0 6.0 EIF2A -0.032 0.079 -9999.0 0.0 -0.275 2.0 2.0 TRADD 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRADD 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 0.015 0.077 0.284 1.0 -9999.0 0.0 1.0 response to heat 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 -0.037 0.099 0.211 1.0 -0.285 2.0 3.0 Cathepsin D/ceramide -0.015 0.076 -9999.0 0.0 -0.198 7.0 7.0 FADD -0.008 0.073 -9999.0 0.0 -9999.0 0.0 0.0 KSR1 -0.004 0.085 0.184 5.0 -0.187 5.0 10.0 MAPK8 -0.003 0.076 -9999.0 0.0 -0.235 1.0 1.0 PRKRA -0.03 0.071 -9999.0 0.0 -0.2 7.0 7.0 PDGFA 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRAF2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.066 0.188 -9999.0 0.0 -0.352 12.0 12.0 mol:GD3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ganglioside biosynthetic process -0.031 0.075 -9999.0 0.0 -0.211 7.0 7.0 CTSD 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of nitric oxide biosynthetic process 0.028 0.066 -9999.0 0.0 -0.424 1.0 1.0 response to radiation 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ERK1/PKC delta -0.005 0.122 -9999.0 0.0 -0.284 5.0 5.0 PRKCD 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PRKCZ 0.022 0.031 -9999.0 0.0 -9999.0 0.0 0.0 mol:GW4869 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:sphingosine 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RelA/NF kappa B1 0.028 0.066 -9999.0 0.0 -0.425 1.0 1.0 mol:glutathione 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PAWR 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD -0.005 0.077 -9999.0 0.0 -9999.0 0.0 0.0 TNFR1A/BAG4/TNF-alpha -0.058 0.176 -9999.0 0.0 -0.372 11.0 11.0 mol:Sphingosine-1-phosphate 0.013 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 -0.003 0.081 -9999.0 0.0 -9999.0 0.0 0.0 mol:C11AG -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CYCS -0.018 0.051 -9999.0 0.0 -0.175 2.0 2.0 TNFRSF1A 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NFKB1 0.015 0.085 -9999.0 0.0 -0.576 1.0 1.0 TNFR1A/BAG4 0.002 0.127 -9999.0 0.0 -0.425 4.0 4.0 EIF2AK2 -0.03 0.067 -9999.0 0.0 -0.271 1.0 1.0 TNF-alpha/TNFR1A/FAN -0.026 0.148 -9999.0 0.0 -0.365 7.0 7.0 response to hydrogen peroxide 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP8 -0.001 0.097 -9999.0 0.0 -0.389 2.0 2.0 MAP2K2 0.018 0.083 0.345 1.0 -9999.0 0.0 1.0 SMPD3 -0.014 0.071 -9999.0 0.0 -9999.0 0.0 0.0 TNF -0.092 0.21 -9999.0 0.0 -0.399 13.0 13.0 PKC zeta/PAR4 0.036 0.024 -9999.0 0.0 -9999.0 0.0 0.0 mol:PHOSPHOCHOLINE -0.019 0.051 -9999.0 0.0 -0.177 2.0 2.0 NF kappa B1/RelA/I kappa B alpha 0.065 0.059 -9999.0 0.0 -0.316 1.0 1.0 AIFM1 -0.022 0.055 -9999.0 0.0 -0.168 3.0 3.0 BCL2 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0