TRAIL signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TNFSF10 0.002 0.119 -9999.0 0.0 -0.576 2.0 2.0 positive regulation of NF-kappaB transcription factor activity 0.01 0.111 -9999.0 0.0 -0.424 3.0 3.0 MAP2K4 0.026 0.096 0.211 5.0 -0.39 1.0 6.0 IKBKB 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TNFRSF10B 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TNFRSF10A -0.01 0.144 -9999.0 0.0 -0.576 3.0 3.0 SMPD1 0.0 0.076 -9999.0 0.0 -0.347 2.0 2.0 IKBKG 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TNFRSF10D 0.015 0.085 -9999.0 0.0 -0.576 1.0 1.0 TRAIL/TRAILR2 0.02 0.092 -9999.0 0.0 -0.425 2.0 2.0 TRAIL/TRAILR3 -0.002 0.128 -9999.0 0.0 -0.425 4.0 4.0 TRAIL/TRAILR1 -0.008 0.141 -9999.0 0.0 -0.425 5.0 5.0 TRAIL/TRAILR4 0.011 0.111 -9999.0 0.0 -0.425 3.0 3.0 TRAIL/TRAILR1/DAP3/GTP 0.012 0.116 -9999.0 0.0 -0.333 5.0 5.0 IKK complex 0.006 0.088 -9999.0 0.0 -0.368 2.0 2.0 RIPK1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to oxidative stress 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DAP3/GTP 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 -0.003 0.087 -9999.0 0.0 -0.424 2.0 2.0 MAP3K1 0.002 0.113 -9999.0 0.0 -0.403 3.0 3.0 TRAILR4 (trimer) 0.014 0.085 -9999.0 0.0 -0.575 1.0 1.0 TRADD 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRAILR1 (trimer) -0.01 0.144 -9999.0 0.0 -0.575 3.0 3.0 TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 -0.008 0.121 -9999.0 0.0 -0.348 5.0 5.0 CFLAR 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 -0.009 0.084 -9999.0 0.0 -0.414 2.0 2.0 TRAIL/TRAILR1/FADD/TRADD/RIP 0.037 0.118 -9999.0 0.0 -0.309 5.0 5.0 mol:ceramide 0.0 0.076 -9999.0 0.0 -0.345 2.0 2.0 FADD 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 0.025 0.115 0.277 1.0 -0.381 2.0 3.0 TRAF2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 TRAILR3 (trimer) -0.002 0.122 -9999.0 0.0 -0.447 3.0 3.0 CHUK 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 TRAIL/TRAILR1/FADD 0.01 0.124 -9999.0 0.0 -0.357 5.0 5.0 DAP3 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP10 -0.007 0.102 0.241 1.0 -0.322 3.0 4.0 JNK cascade 0.01 0.111 -9999.0 0.0 -0.424 3.0 3.0 TRAIL (trimer) 0.002 0.119 -9999.0 0.0 -0.575 2.0 2.0 TNFRSF10C -0.002 0.122 -9999.0 0.0 -0.448 3.0 3.0 TRAIL/TRAILR1/DAP3/GTP/FADD 0.023 0.112 -9999.0 0.0 -0.308 5.0 5.0 TRAIL/TRAILR2/FADD 0.034 0.082 -9999.0 0.0 -0.355 2.0 2.0 cell death 0.0 0.076 -9999.0 0.0 -0.344 2.0 2.0 TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 0.014 0.084 -9999.0 0.0 -0.372 2.0 2.0 TRAILR2 (trimer) 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP8 0.012 0.028 -9999.0 0.0 -9999.0 0.0 0.0 negative regulation of caspase activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRAIL/TRAILR2/FADD/TRADD/RIP 0.059 0.078 -9999.0 0.0 -0.308 2.0 2.0