VEGFR1 specific signals Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR1 homodimer/VEGFB homodimer 0.01 0.119 -9999.0 0.0 -0.531 2.0 2.0 VEGFR1 homodimer/NRP1 -0.007 0.115 -9999.0 0.0 -0.529 2.0 2.0 mol:DAG -0.019 0.128 -9999.0 0.0 -0.426 4.0 4.0 VEGFR1 homodimer/NRP1/VEGFR 121 0.009 0.11 -9999.0 0.0 -0.491 2.0 2.0 CaM/Ca2+ -0.003 0.126 -9999.0 0.0 -0.405 4.0 4.0 HIF1A 0.012 0.1 -9999.0 0.0 -0.461 2.0 2.0 GAB1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.025 0.169 -9999.0 0.0 -0.759 2.0 2.0 PLCG1 -0.019 0.129 -9999.0 0.0 -0.429 4.0 4.0 NOS3 -0.02 0.139 -9999.0 0.0 -0.542 2.0 2.0 CBL 0.013 0.085 -9999.0 0.0 -0.576 1.0 1.0 mol:NO -0.006 0.153 0.467 1.0 -0.52 2.0 3.0 FLT1 -0.006 0.131 -9999.0 0.0 -0.604 2.0 2.0 PGF -0.003 0.122 -9999.0 0.0 -0.448 3.0 3.0 VEGFR1 homodimer/NRP2/VEGFR121 0.026 0.114 -9999.0 0.0 -0.492 2.0 2.0 CALM1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.014 0.085 -9999.0 0.0 -0.576 1.0 1.0 eNOS/Hsp90 -0.002 0.139 -9999.0 0.0 -0.506 2.0 2.0 endothelial cell proliferation -0.047 0.15 -9999.0 0.0 -0.456 4.0 4.0 mol:Ca2+ -0.019 0.127 -9999.0 0.0 -0.422 4.0 4.0 MAPK3 -0.039 0.115 -9999.0 0.0 -0.469 2.0 2.0 MAPK1 -0.032 0.11 -9999.0 0.0 -0.469 2.0 2.0 PIK3R1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PLGF homodimer -0.003 0.122 -9999.0 0.0 -0.447 3.0 3.0 PRKACA 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RP11-342D11.1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CAV1 0.022 0.031 -9999.0 0.0 -0.192 1.0 1.0 VEGFA homodimer 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR1 homodimer/VEGFA homodimer 0.01 0.119 -9999.0 0.0 -0.531 2.0 2.0 platelet activating factor biosynthetic process -0.032 0.107 -9999.0 0.0 -0.457 2.0 2.0 PI3K 0.016 0.157 -9999.0 0.0 -0.48 4.0 4.0 PRKCA -0.032 0.123 -9999.0 0.0 -0.378 5.0 5.0 PRKCB -0.067 0.148 -9999.0 0.0 -0.359 9.0 9.0 VEGFR1 homodimer/PLGF homodimer -0.007 0.144 -9999.0 0.0 -0.467 4.0 4.0 VEGFA 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VEGFB 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 -0.019 0.128 -9999.0 0.0 -0.426 4.0 4.0 RASA1 -0.01 0.131 -9999.0 0.0 -0.642 2.0 2.0 NRP2 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR1 homodimer -0.005 0.13 -9999.0 0.0 -0.602 2.0 2.0 VEGFB homodimer 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.014 0.085 -9999.0 0.0 -0.576 1.0 1.0 eNOS/Caveolin-1 0.021 0.194 0.649 2.0 -0.506 2.0 4.0 PTPN11 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.014 0.154 -9999.0 0.0 -0.474 4.0 4.0 mol:L-citrulline -0.006 0.153 0.467 1.0 -0.52 2.0 3.0 VEGFR1 homodimer/VEGFA homodimer/CBL/CD2AP 0.032 0.135 -9999.0 0.0 -0.616 2.0 2.0 VEGFR1 homodimer/VEGFA homodimer/NCK1 0.018 0.138 -9999.0 0.0 -0.644 2.0 2.0 CD2AP 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K/GAB1 0.026 0.154 -9999.0 0.0 -0.623 2.0 2.0 PDPK1 -0.016 0.173 0.339 1.0 -0.746 2.0 3.0 VEGFR1 homodimer/VEGFA homodimer/SHP2 0.026 0.114 -9999.0 0.0 -0.492 2.0 2.0 mol:NADP -0.006 0.153 0.467 1.0 -0.52 2.0 3.0 HSP90AA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ubiquitin-dependent protein catabolic process 0.031 0.133 -9999.0 0.0 -0.607 2.0 2.0 VEGFR1 homodimer/NRP2 0.01 0.119 -9999.0 0.0 -0.531 2.0 2.0