TCR signaling in naïve CD8+ T cells Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations GRB2/SOS1/SHC -0.042 0.172 -9999.0 0.0 -0.517 4.0 4.0 FYN -0.089 0.233 -9999.0 0.0 -0.577 7.0 7.0 LAT/GRAP2/SLP76 -0.079 0.183 -9999.0 0.0 -0.522 5.0 5.0 IKBKB 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.08 0.154 -9999.0 0.0 -0.394 7.0 7.0 B2M 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IKBKG -0.022 0.048 -9999.0 0.0 -0.136 3.0 3.0 MAP3K8 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.021 0.033 0.089 1.0 -0.091 5.0 6.0 integrin-mediated signaling pathway 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LAT/GRAP2/SLP76/VAV1/PI3K Class IA -0.112 0.227 -9999.0 0.0 -0.583 7.0 7.0 TRPV6 -0.06 0.249 1.161 1.0 -0.576 5.0 6.0 CD28 -0.039 0.169 -9999.0 0.0 -0.413 7.0 7.0 SHC1 -0.083 0.225 -9999.0 0.0 -0.599 6.0 6.0 receptor internalization -0.069 0.209 -9999.0 0.0 -0.622 5.0 5.0 PRF1 -0.082 0.3 -9999.0 0.0 -0.889 5.0 5.0 KRAS 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB2 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 COT/AKT1 -0.06 0.129 -9999.0 0.0 -0.333 6.0 6.0 LAT -0.087 0.241 -9999.0 0.0 -0.639 6.0 6.0 EntrezGene:6955 -0.001 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CD3D -0.039 0.156 -9999.0 0.0 -0.322 9.0 9.0 CD3E -0.018 0.132 -9999.0 0.0 -0.351 5.0 5.0 CD3G -0.024 0.132 -9999.0 0.0 -0.451 3.0 3.0 RASGRP2 -0.015 0.038 -9999.0 0.0 -0.153 3.0 3.0 RASGRP1 -0.053 0.151 -9999.0 0.0 -0.415 5.0 5.0 HLA-A 0.025 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RASSF5 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A/GTP/RAPL 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.007 0.047 -9999.0 0.0 -0.123 3.0 3.0 PDK1/CARD11/BCL10/MALT1/TRAF6 -0.048 0.071 -9999.0 0.0 -0.214 5.0 5.0 PRKCA -0.029 0.092 -9999.0 0.0 -0.262 4.0 4.0 GRAP2 0.009 0.032 -9999.0 0.0 -0.192 1.0 1.0 mol:IP3 -0.047 0.159 0.236 2.0 -0.424 5.0 7.0 EntrezGene:6957 -0.001 0.005 -9999.0 0.0 -9999.0 0.0 0.0 TCR/CD3/MHC I/CD8 -0.057 0.188 -9999.0 0.0 -0.564 5.0 5.0 ORAI1 0.028 0.177 -9999.0 0.0 -0.977 1.0 1.0 CSK -0.085 0.229 -9999.0 0.0 -0.606 6.0 6.0 B7 family/CD28 -0.076 0.254 -9999.0 0.0 -0.559 8.0 8.0 CHUK 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 TCR/CD3/MHC I/CD8/LCK/ZAP-70 -0.093 0.262 -9999.0 0.0 -0.69 6.0 6.0 PTPN6 -0.085 0.233 -9999.0 0.0 -0.614 6.0 6.0 VAV1 -0.079 0.26 0.28 1.0 -0.676 6.0 7.0 Monovalent TCR/CD3 -0.044 0.158 -9999.0 0.0 -0.47 5.0 5.0 CBL 0.013 0.085 -9999.0 0.0 -0.576 1.0 1.0 LCK -0.09 0.237 -9999.0 0.0 -0.58 7.0 7.0 PAG1 -0.091 0.227 -9999.0 0.0 -0.612 6.0 6.0 RAP1A 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TCR/CD3/MHC I/CD8/LCK -0.092 0.263 -9999.0 0.0 -0.691 6.0 6.0 CD80 -0.019 0.13 -9999.0 0.0 -0.321 6.0 6.0 CD86 0.004 0.095 -9999.0 0.0 -0.323 3.0 3.0 PDK1/CARD11/BCL10/MALT1 -0.053 0.089 -9999.0 0.0 -0.257 5.0 5.0 HRAS 0.02 0.031 -9999.0 0.0 -0.192 1.0 1.0 GO:0035030 -0.091 0.196 -9999.0 0.0 -0.468 8.0 8.0 CD8A 0.003 0.096 -9999.0 0.0 -0.324 3.0 3.0 CD8B -0.058 0.189 -9999.0 0.0 -0.387 10.0 10.0 PTPRC -0.028 0.167 -9999.0 0.0 -0.502 5.0 5.0 PDK1/PKC theta -0.088 0.193 -9999.0 0.0 -0.481 7.0 7.0 CSK/PAG1 -0.086 0.222 -9999.0 0.0 -0.59 6.0 6.0 SOS1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 peptide-MHC class I 0.036 0.015 -9999.0 0.0 -9999.0 0.0 0.0 GRAP2/SLP76 -0.088 0.208 -9999.0 0.0 -0.513 7.0 7.0 STIM1 0.04 0.172 1.165 1.0 -9999.0 0.0 1.0 RAS family/GTP -0.0 0.067 -9999.0 0.0 -0.182 3.0 3.0 TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin -0.074 0.221 -9999.0 0.0 -0.659 5.0 5.0 mol:DAG -0.055 0.132 -9999.0 0.0 -0.335 7.0 7.0 RAP1A/GDP -0.0 0.024 -9999.0 0.0 -0.064 1.0 1.0 PLCG1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CD247 0.012 0.053 -9999.0 0.0 -0.194 3.0 3.0 cytotoxic T cell degranulation -0.077 0.282 -9999.0 0.0 -0.838 5.0 5.0 RAP1A/GTP -0.005 0.015 -9999.0 0.0 -0.065 2.0 2.0 mol:PI-3-4-5-P3 -0.092 0.184 -9999.0 0.0 -0.473 7.0 7.0 LAT/GRAP2/SLP76/VAV1/PLCgamma1 -0.063 0.204 0.248 2.0 -0.561 5.0 7.0 NRAS 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZAP70 0.001 0.098 -9999.0 0.0 -0.288 4.0 4.0 GRB2/SOS1 0.034 0.014 -9999.0 0.0 -9999.0 0.0 0.0 LAT/GRAP2/SLP76/VAV1 -0.08 0.194 -9999.0 0.0 -0.492 7.0 7.0 MALT1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 TRAF6 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CD8 heterodimer -0.04 0.161 -9999.0 0.0 -0.385 8.0 8.0 CARD11 0.006 0.094 -9999.0 0.0 -0.32 3.0 3.0 PRKCB -0.055 0.123 -9999.0 0.0 -0.273 9.0 9.0 PRKCE -0.028 0.098 -9999.0 0.0 -0.287 4.0 4.0 PRKCQ -0.094 0.218 -9999.0 0.0 -0.551 7.0 7.0 LCP2 0.013 0.052 -9999.0 0.0 -0.192 3.0 3.0 BCL10 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of survival gene product expression -0.067 0.132 -9999.0 0.0 -0.333 7.0 7.0 IKK complex 0.002 0.057 0.124 3.0 -0.112 3.0 6.0 RAS family/GDP -0.004 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K14 -0.043 0.092 -9999.0 0.0 -0.262 4.0 4.0 PDPK1 -0.08 0.149 -9999.0 0.0 -0.367 8.0 8.0 TCR/CD3/MHC I/CD8/Fyn -0.094 0.293 -9999.0 0.0 -0.657 8.0 8.0