EGFR-dependent Endothelin signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations HRAS 0.02 0.031 -9999.0 0.0 -0.192 1.0 1.0 EGFR -0.048 0.185 -9999.0 0.0 -0.432 8.0 8.0 EGF/EGFR -0.011 0.141 -9999.0 0.0 -0.349 6.0 6.0 EGF/EGFR dimer/SHC/GRB2/SOS1 0.017 0.133 -9999.0 0.0 -0.341 5.0 5.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EDNRA 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to oxidative stress 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGF 0.006 0.094 -9999.0 0.0 -0.576 1.0 1.0 EGF/EGFR dimer/SHC -0.008 0.157 -9999.0 0.0 -0.428 5.0 5.0 mol:GDP 0.009 0.13 -9999.0 0.0 -0.338 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EDN1 0.01 0.09 -9999.0 0.0 -0.384 2.0 2.0 GRB2/SOS1 0.034 0.014 -9999.0 0.0 -9999.0 0.0 0.0 HRAS/GTP -0.005 0.119 -9999.0 0.0 -0.327 5.0 5.0 SHC1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HRAS/GDP 0.007 0.127 -9999.0 0.0 -0.334 5.0 5.0 FRAP1 -0.046 0.1 -9999.0 0.0 -0.324 5.0 5.0 EGF/EGFR dimer -0.029 0.173 -9999.0 0.0 -0.42 7.0 7.0 SOS1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB2 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ETA receptor/Endothelin-1 0.027 0.069 -9999.0 0.0 -0.425 1.0 1.0