S1P1 pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR2 homodimer/VEGFA homodimer 0.02 0.092 -9999.0 0.0 -0.425 2.0 2.0 PDGFRB 0.013 0.085 -9999.0 0.0 -0.576 1.0 1.0 SPHK1 0.009 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:S1P 0.001 0.025 -9999.0 0.0 -9999.0 0.0 0.0 S1P1/S1P/Gi -0.037 0.124 -9999.0 0.0 -0.349 5.0 5.0 GNAO1 -0.066 0.199 -9999.0 0.0 -0.421 10.0 10.0 PDGFB-D/PDGFRB/PLCgamma1 -0.046 0.111 -9999.0 0.0 -0.356 4.0 4.0 PLCG1 -0.031 0.112 -9999.0 0.0 -0.346 4.0 4.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PDGFB-D/PDGFRB 0.013 0.085 -9999.0 0.0 -0.575 1.0 1.0 GNAI2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 GNAI3 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GNAI1 0.021 0.031 -9999.0 0.0 -0.191 1.0 1.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EDG1 -0.008 0.073 -9999.0 0.0 -0.36 2.0 2.0 S1P1/S1P -0.009 0.072 -9999.0 0.0 -0.329 2.0 2.0 negative regulation of cAMP metabolic process -0.036 0.121 -9999.0 0.0 -0.341 5.0 5.0 MAPK3 -0.04 0.132 -9999.0 0.0 -0.451 3.0 3.0 calcium-dependent phospholipase C activity -0.001 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 KDR 0.002 0.119 -9999.0 0.0 -0.576 2.0 2.0 PLCB2 -0.009 0.067 -9999.0 0.0 -0.301 2.0 2.0 RAC1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.001 0.064 -9999.0 0.0 -0.287 2.0 2.0 receptor internalization -0.009 0.068 -9999.0 0.0 -0.31 2.0 2.0 PTGS2 -0.049 0.173 -9999.0 0.0 -0.73 2.0 2.0 Rac1/GTP 0.001 0.064 -9999.0 0.0 -0.287 2.0 2.0 RHOA 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VEGFA 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 negative regulation of T cell proliferation -0.036 0.121 -9999.0 0.0 -0.341 5.0 5.0 GO:0007205 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAZ 0.013 0.014 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 -0.03 0.125 -9999.0 0.0 -0.446 3.0 3.0 S1P1/S1P/PDGFB-D/PDGFRB -0.013 0.095 -9999.0 0.0 -0.428 2.0 2.0 ABCC1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0