Signaling events mediated by PTP1B Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PDGFRB 0.014 0.085 -9999.0 0.0 -0.576 1.0 1.0 Jak2/Leptin Receptor 0.012 0.148 0.284 2.0 -0.377 4.0 6.0 PTP1B/AKT1 0.01 0.096 0.198 1.0 -0.455 1.0 2.0 FYN 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p210 bcr-abl/PTP1B 0.002 0.11 0.254 2.0 -0.37 2.0 4.0 EGFR -0.048 0.188 -9999.0 0.0 -0.437 8.0 8.0 EGF/EGFR -0.015 0.161 0.242 1.0 -0.456 4.0 5.0 CSF1 0.002 0.119 -9999.0 0.0 -0.576 2.0 2.0 AKT1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 INSR 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PTP1B/N-cadherin -0.032 0.139 -9999.0 0.0 -0.312 8.0 8.0 Insulin Receptor/Insulin 0.008 0.081 -9999.0 0.0 -0.386 1.0 1.0 HCK 0.008 0.06 -9999.0 0.0 -0.192 4.0 4.0 CRK 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 0.023 0.127 0.275 5.0 -0.355 2.0 7.0 EGF 0.003 0.097 -9999.0 0.0 -0.589 1.0 1.0 YES1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CAV1 0.007 0.113 0.274 2.0 -0.516 1.0 3.0 TXN 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTP1B/IRS1/GRB2 0.01 0.087 -9999.0 0.0 -0.462 1.0 1.0 cell migration -0.002 0.11 0.37 2.0 -0.254 2.0 4.0 STAT3 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PRLR -0.007 0.106 -9999.0 0.0 -0.254 6.0 6.0 ITGA2B -0.068 0.211 -9999.0 0.0 -0.578 7.0 7.0 CSF1R 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Prolactin Receptor/Prolactin 0.005 0.088 -9999.0 0.0 -0.432 1.0 1.0 FGR 0.022 0.031 -9999.0 0.0 -0.192 1.0 1.0 PTP1B/p130 Cas 0.011 0.108 0.288 1.0 -0.355 2.0 3.0 Crk/p130 Cas 0.014 0.087 -9999.0 0.0 -0.446 1.0 1.0 DOK1 0.013 0.12 0.304 2.0 -0.434 2.0 4.0 JAK2 -0.006 0.144 0.292 1.0 -0.405 4.0 5.0 Jak2/Leptin Receptor/Leptin -0.061 0.161 -9999.0 0.0 -0.426 5.0 5.0 PIK3R1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTPN1 0.002 0.111 0.255 2.0 -0.373 2.0 4.0 LYN 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH2 -0.049 0.197 -9999.0 0.0 -0.576 6.0 6.0 SRC 0.03 0.044 -9999.0 0.0 -9999.0 0.0 0.0 ITGB3 -0.031 0.166 -9999.0 0.0 -0.578 4.0 4.0 CAT1/PTP1B -0.012 0.134 0.331 1.0 -0.366 3.0 4.0 CAPN1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CSK 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.009 0.11 -9999.0 0.0 -0.621 1.0 1.0 mol:H2O2 -0.0 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 (dimer) -0.06 0.162 -9999.0 0.0 -0.443 5.0 5.0 negative regulation of transcription -0.003 0.143 0.291 1.0 -0.4 4.0 5.0 FCGR2A 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FER 0.014 0.087 -9999.0 0.0 -0.587 1.0 1.0 alphaIIb/beta3 Integrin -0.074 0.208 -9999.0 0.0 -0.471 10.0 10.0 BLK -0.081 0.199 -9999.0 0.0 -0.369 13.0 13.0 Insulin Receptor/Insulin/Shc 0.037 0.02 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LEPR 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BCAR1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p210 bcr-abl/Grb2 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:NADPH 0.0 0.003 -9999.0 0.0 -9999.0 0.0 0.0 TRPV6 -0.014 0.118 -9999.0 0.0 -0.372 2.0 2.0 PRL -0.006 0.044 -9999.0 0.0 -0.192 2.0 2.0 SOCS3 -0.133 0.407 -9999.0 0.0 -1.221 6.0 6.0 SPRY2 0.021 0.031 -9999.0 0.0 -0.187 1.0 1.0 Insulin Receptor/Insulin/IRS1 0.037 0.02 -9999.0 0.0 -9999.0 0.0 0.0 CSF1/CSF1R 0.014 0.152 0.289 1.0 -0.622 2.0 3.0 Ras protein signal transduction 0.068 0.182 0.487 7.0 -9999.0 0.0 7.0 IRS1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 INS -0.008 0.016 -9999.0 0.0 -9999.0 0.0 0.0 LEP -0.054 0.144 -9999.0 0.0 -0.356 7.0 7.0 STAT5B 0.004 0.115 0.25 2.0 -0.323 3.0 5.0 STAT5A 0.004 0.115 0.25 2.0 -0.323 3.0 5.0 GRB2 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PDGFB-D/PDGFRB 0.008 0.126 0.288 1.0 -0.5 2.0 3.0 CSN2 -0.003 0.04 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.014 0.085 -9999.0 0.0 -0.576 1.0 1.0 LAT 0.019 0.089 -9999.0 0.0 -0.521 1.0 1.0 YBX1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LCK 0.008 0.06 -9999.0 0.0 -0.192 4.0 4.0 SHC1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NOX4 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0