ErbB2/ErbB3 signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations USP8 -0.002 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP -0.019 0.122 -9999.0 0.0 -0.295 2.0 2.0 NFATC4 -0.05 0.135 0.222 1.0 -0.401 3.0 4.0 ERBB2IP 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 HSP90 (dimer) 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mammary gland morphogenesis -0.043 0.121 -9999.0 0.0 -0.3 8.0 8.0 JUN -0.033 0.08 -9999.0 0.0 -0.288 2.0 2.0 HRAS 0.02 0.031 -9999.0 0.0 -0.192 1.0 1.0 DOCK7 -0.045 0.128 -9999.0 0.0 -0.29 8.0 8.0 ErbB2/ErbB3/neuregulin 1 beta/SHC -0.032 0.145 -9999.0 0.0 -0.327 9.0 9.0 AKT1 0.005 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BAD -0.002 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MAPK10 -0.017 0.093 0.211 3.0 -9999.0 0.0 3.0 mol:GTP -0.001 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ErbB2/ErbB3/neuregulin 1 beta -0.045 0.13 -9999.0 0.0 -0.321 8.0 8.0 RAF1 -0.039 0.119 -9999.0 0.0 -0.38 1.0 1.0 ErbB2/ErbB3/neuregulin 2 -0.028 0.122 -9999.0 0.0 -0.344 6.0 6.0 STAT3 0.029 0.015 -9999.0 0.0 -9999.0 0.0 0.0 cell migration -0.01 0.097 0.223 3.0 -0.227 1.0 4.0 mol:PI-3-4-5-P3 -0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0 cell proliferation -0.17 0.26 -9999.0 0.0 -0.611 11.0 11.0 FOS -0.117 0.193 -9999.0 0.0 -0.439 11.0 11.0 NRAS 0.026 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.043 0.121 -9999.0 0.0 -0.3 8.0 8.0 MAPK3 -0.075 0.209 -9999.0 0.0 -0.562 5.0 5.0 MAPK1 -0.239 0.269 -9999.0 0.0 -0.669 11.0 11.0 JAK2 -0.041 0.121 -9999.0 0.0 -0.29 8.0 8.0 NF2 -0.022 0.123 -9999.0 0.0 -0.611 2.0 2.0 ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 -0.022 0.134 0.182 3.0 -0.279 9.0 12.0 NRG1 -0.052 0.198 -9999.0 0.0 -0.52 7.0 7.0 GRB2/SOS1 0.034 0.014 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 -0.044 0.136 -9999.0 0.0 -0.302 9.0 9.0 MAPK9 -0.022 0.082 0.172 2.0 -9999.0 0.0 2.0 ERBB2 -0.017 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ERBB3 -0.023 0.165 -9999.0 0.0 -0.578 4.0 4.0 SHC1 0.026 0.001 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 apoptosis 0.005 0.015 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 (dimer) 0.029 0.015 -9999.0 0.0 -9999.0 0.0 0.0 RNF41 -0.005 0.012 -9999.0 0.0 -9999.0 0.0 0.0 FRAP1 -0.001 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1-CDC42/GTP -0.041 0.089 -9999.0 0.0 -0.229 2.0 2.0 ErbB2/ErbB2/HSP90 (dimer) 0.006 0.018 -9999.0 0.0 -9999.0 0.0 0.0 CHRNA1 -0.135 0.224 -9999.0 0.0 -0.531 10.0 10.0 myelination -0.039 0.141 0.306 2.0 -0.413 2.0 4.0 PPP3CB -0.04 0.114 -9999.0 0.0 -0.273 8.0 8.0 KRAS 0.026 0.001 -9999.0 0.0 -9999.0 0.0 0.0 RAC1-CDC42/GDP 0.0 0.126 -9999.0 0.0 -0.262 1.0 1.0 NRG2 -0.01 0.125 -9999.0 0.0 -0.384 4.0 4.0 mol:GDP -0.022 0.134 0.182 3.0 -0.278 9.0 12.0 SOS1 0.026 0.001 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K2 -0.039 0.116 -9999.0 0.0 -0.433 1.0 1.0 SRC 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:cAMP -0.001 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PTPN11 -0.037 0.128 0.249 1.0 -0.29 8.0 9.0 MAP2K1 -0.086 0.202 -9999.0 0.0 -0.454 7.0 7.0 heart morphogenesis -0.043 0.121 -9999.0 0.0 -0.3 8.0 8.0 RAS family/GDP -0.007 0.124 -9999.0 0.0 -0.299 1.0 1.0 GRB2 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PRKACA -0.018 0.131 -9999.0 0.0 -0.641 2.0 2.0 CHRNE -0.003 0.037 0.085 1.0 -0.21 1.0 2.0 HSP90AA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 activation of caspase activity -0.005 0.008 -9999.0 0.0 -9999.0 0.0 0.0 nervous system development -0.043 0.121 -9999.0 0.0 -0.3 8.0 8.0 CDC42 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0