Dear TCGA Colleagues,

The January 2013 Firehose analysis run has been uploaded and will be available in
the protected data tree pending internal mirroring by the DCC.  This analysis
run was based upon version 2013_01_16 of the Firehose stddata package, and is
described in more detail on our site at

			http://gdac.broadinstitute.org

The highlights of this run are given below and in the dashboard release notes.
If you have any questions or comments please do not hesitate to send them to
our gdac@broadinstitute.org mailing list.


Regards,
Michael S. Noble
Broad Institute of MIT & Harvard

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* Sample Changes:
   BCR         +161 (7468 total)
   Clinical    +40  (5949 total)
   CN          +122 (6552 total)
   MAF         +136 (3934 total)
   Methylation +96  (6618 total)
   mRNA        -2   (2222 total)
   mRNAseq     +110 (4790 total)

* PARADIGM mRNASeq input now being median centered using normals if they exist

* New pipeline added: HotNet analyses on 20 disease cohorts

* Analysis reports:
  . Increased in number from 551 to 614
  . Now reflect the diease cohort over which the analysis was performed: e.g.
    primary solid tumor, metastatic, subtype designations (like astrocytoma) etc

* LGG MAF-swap issue corrected (see stddata release notes for 2012_12_21)