Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
LRRC47	57470	broad.mit.edu	37	1	3703592	3703592	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:3703592C>G	uc001akx.1	-	2	926	c.898G>C	c.(898-900)GAC>CAC	p.D300H		NM_020710	NP_065761	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	300					translation		phenylalanine-tRNA ligase activity|RNA binding			large_intestine(1)|ovary(1)	2	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		tctcccacgtcctgctcctcc	0.393000													17	14					0	0	0	0
FBXO6	26270	broad.mit.edu	37	1	11728956	11728956	+	Silent	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:11728956C>T	uc001aso.2	+	2	407	c.241C>T	c.(241-243)CTA>TTA	p.L81L		NM_018438	NP_060908	Q9NRD1	FBX6_HUMAN	F-box only protein 6	81	FBA.				DNA damage checkpoint|DNA repair|ER-associated protein catabolic process|response to unfolded protein|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	glycoprotein binding			lung(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.25e-06)|COAD - Colon adenocarcinoma(227;0.000251)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		CTTCTACTTCCTACGGAGCCT	0.522000													6	91					0	0	0	0
TNFRSF1B	7133	broad.mit.edu	37	1	12251958	12251958	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:12251958G>A	uc001att.2	+	4	524	c.435G>A	c.(433-435)CCG>CCA	p.P145P	TNFRSF1B_uc001atu.2_5'UTR|TNFRSF1B_uc009vnk.2_RNA	NM_001066	NP_001057	P20333	TNR1B_HUMAN	tumor necrosis factor receptor 2 precursor	145	TNFR-Cys 3.|Extracellular (Potential).				apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			liver(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	AGTGCCGCCCGGGCTTCGGCG	0.687000													30	19					0	0	0	0
EPHA2	1969	broad.mit.edu	37	1	16464404	16464404	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:16464404G>C	uc001aya.1	-	5	1393	c.1256C>G	c.(1255-1257)TCA>TGA	p.S419*	EPHA2_uc010oca.1_Nonsense_Mutation_p.S419*	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	419	Extracellular (Potential).|Fibronectin type-III 1.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	TACCAGGCCTGAGACGCCATT	0.637000													38	36					0	0	0	0
MST1P2	11209	broad.mit.edu	37	1	16974549	16974549	+	RNA	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:16974549C>G	uc009vow.2	+	5		c.1359C>G			MST1P2_uc010ocg.1_RNA|MST1P2_uc010och.1_RNA|MST1P2_uc010oci.1_RNA|MST1P2_uc001azk.2_RNA|MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_RNA|MST1P2_uc001azm.3_RNA					Homo sapiens cDNA FLJ53774 complete cds, moderately similar to Hepatocyte growth factor-like protein precursor.												0						GGGCTGAGTGCAGCGCCTGCT	0.692000													11	55					0	0	0	0
MST1P9	11223	broad.mit.edu	37	1	17083837	17083837	+	Missense_Mutation	SNP	T	C	C	rs7798	by1000genomes	TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:17083837T>C	uc010ock.1	-	15	1960	c.1960A>G	c.(1960-1962)AAA>GAA	p.K654E	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_Missense_Mutation_p.K254E	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						CTAATTCCTTTCAGGACCCAG	0.572000													3	63					0	0	0	0
CLSPN	63967	broad.mit.edu	37	1	36228069	36228069	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:36228069G>A	uc001bzi.2	-	5	838	c.758C>T	c.(757-759)TCT>TTT	p.S253F	CLSPN_uc009vux.2_Missense_Mutation_p.S253F	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	253					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ACTCTCCAAAGATGGTTCTTT	0.398000													58	59					0	0	0	0
FAM151A	338094	broad.mit.edu	37	1	55089015	55089015	+	Silent	SNP	G	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:55089015G>T	uc001cxn.2	-	1	186	c.54C>A	c.(52-54)GGC>GGA	p.G18G	ACOT11_uc001cxm.1_Intron	NM_176782	NP_788954	Q8WW52	F151A_HUMAN	hypothetical protein LOC338094	18	Helical; (Potential).					integral to membrane					0						CACAGGTAATGCCGGCAAACA	0.597000													114	98					4.64626e-59	5.23588e-59	1	0
HAO2	51179	broad.mit.edu	37	1	119923746	119923746	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:119923746C>T	uc001ehq.1	+	3	390	c.38C>T	c.(37-39)GCG>GTG	p.A13V	HAO2_uc001ehr.1_Missense_Mutation_p.A13V	NM_001005783	NP_001005783	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2	13	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			ovary(2)|skin(2)	4	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		CAGGCCCATGCGCGAGAGCAG	0.473000													6	259					0	0	0	0
ADAR	103	broad.mit.edu	37	1	154574600	154574600	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:154574600T>C	uc001ffh.2	-	2	718	c.518A>G	c.(517-519)AAT>AGT	p.N173S	ADAR_uc001ffj.2_Missense_Mutation_p.N173S|ADAR_uc001ffi.2_Missense_Mutation_p.N173S|ADAR_uc001ffk.2_5'UTR|ADAR_uc001ffl.1_5'UTR	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	173	|DRADA 1.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		TAAAACTCGATTGATTTCTTT	0.498000													81	275					0	0	0	0
PMVK	10654	broad.mit.edu	37	1	154898894	154898894	+	Silent	SNP	C	T	T	rs137902262	byFrequency	TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:154898894C>T	uc001ffq.2	-	4	701	c.378G>A	c.(376-378)ACG>ACA	p.T126T		NM_006556	NP_006547	Q15126	PMVK_HUMAN	phosphomevalonate kinase	126					cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding				0	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGACCGTCTGCGTCACGGCCC	0.617000													19	48					0	0	0	0
EFNA3	1944	broad.mit.edu	37	1	155057801	155057801	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:155057801G>A	uc001fhf.2	+	2	433	c.363G>A	c.(361-363)AAG>AAA	p.K121K	EFNA3_uc010pew.1_Silent_p.K116K|EFNA3_uc010pex.1_Silent_p.K121K|EFNA3_uc001fhg.2_Silent_p.K98K	NM_004952	NP_004943	P52797	EFNA3_HUMAN	ephrin A3 precursor	121					cell-cell signaling	anchored to membrane|integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity				0	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		all cancers(21;5.67e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000284)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCCCCATCAAGTTCTCGGAGA	0.647000													5	21					0	0	0	0
SPTA1	6708	broad.mit.edu	37	1	158650472	158650472	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:158650472G>A	uc001fst.1	-	5	778	c.579C>T	c.(577-579)ACC>ACT	p.T193T		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	193	Spectrin 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GCAGAACTTCGGTGCGCTCCC	0.463000													36	125					0	0	0	0
FCRLB	127943	broad.mit.edu	37	1	161693366	161693366	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:161693366C>T	uc001gbh.2	+	5	496	c.262C>T	c.(262-264)CGG>TGG	p.R88W	FCRLB_uc009wus.2_Missense_Mutation_p.R88W|FCRLB_uc001gbj.2_Missense_Mutation_p.R88W|FCRLB_uc001gbk.2_Missense_Mutation_p.R88W|FCRLB_uc001gbl.2_Missense_Mutation_p.R81W|FCRLB_uc001gbm.2_Missense_Mutation_p.R81W|FCRLB_uc001gbi.2_Missense_Mutation_p.R88W|FCRLB_uc001gbn.3_5'Flank	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	88	Ig-like C2-type 1.					endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			ATGCCAGACACGGGGAGCACC	0.577000													30	65					0	0	0	0
DNM3	26052	broad.mit.edu	37	1	172348185	172348185	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:172348185G>C	uc001gie.2	+	18	2097	c.1921G>C	c.(1921-1923)GAA>CAA	p.E641Q	DNM3_uc001gif.2_Missense_Mutation_p.E637Q|DNM3_uc001gih.1_5'UTR	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	647					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						TGGACAAGCAGAAAACTTTTC	0.388000													13	36					0	0	0	0
ZBTB37	84614	broad.mit.edu	37	1	173842693	173842693	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:173842693C>A	uc009wwp.1	+	4	1288	c.1012C>A	c.(1012-1014)CCC>ACC	p.P338T	ZBTB37_uc001gjp.1_Intron|ZBTB37_uc001gjq.3_Missense_Mutation_p.P338T|ZBTB37_uc001gjr.2_Missense_Mutation_p.P338T	NM_001122770	NP_001116242	Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37 isoform	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCCTAAGCAACCCAGCTCCCA	0.458000													14	66					6.72482e-11	7.07541e-11	1	0
NR5A2	2494	broad.mit.edu	37	1	200014674	200014674	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:200014674G>A	uc001gvb.2	+	4	631	c.425G>A	c.(424-426)CGT>CAT	p.R142H	NR5A2_uc001gvc.2_Missense_Mutation_p.R96H|NR5A2_uc009wzh.2_Missense_Mutation_p.R102H|NR5A2_uc010pph.1_Missense_Mutation_p.R70H	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	142	Nuclear receptor.|NR C4-type.				embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					CCTTACTGTCGTTTTCAAAAA	0.343000													22	73					0	0	0	0
CACNA1S	779	broad.mit.edu	37	1	201079386	201079386	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:201079386G>A	uc001gvv.2	-	2	391	c.164C>T	c.(163-165)ACG>ATG	p.T55M		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	55	I.|Helical; Name=S1 of repeat I; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CAAGATGATCGTCTCGAAGGG	0.572000													24	53					0	0	0	0
ZC3H11A	9877	broad.mit.edu	37	1	203821361	203821361	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:203821361G>A	uc001hac.2	+	20	2883	c.2267G>A	c.(2266-2268)CGA>CAA	p.R756Q	ZC3H11A_uc001had.2_Missense_Mutation_p.R756Q|ZC3H11A_uc001hae.2_Missense_Mutation_p.R756Q|ZC3H11A_uc001haf.2_Missense_Mutation_p.R756Q|ZC3H11A_uc010pqm.1_Missense_Mutation_p.R702Q	NM_014827	NP_055642	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	756							nucleic acid binding|protein binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			AAAACTCGCCGACTCAGCTCT	0.507000													36	83					0	0	0	0
ACTA1	58	broad.mit.edu	37	1	229567573	229567573	+	Silent	SNP	C	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr1:229567573C>A	uc001htm.2	-	6	990	c.885G>T	c.(883-885)CTG>CTT	p.L295L		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	295					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	TGTTGGCATACAGGTCCTTCC	0.597000													4	126					0.00116845	0.00118988	1	0
C10orf113	387638	broad.mit.edu	37	10	21435284	21435284	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr10:21435284G>A	uc001iqm.2	-	1	144	c.124C>T	c.(124-126)CCA>TCA	p.P42S	NEBL_uc001iqk.2_Intron	NM_001010896	NP_001010896	Q5VZT2	CJ113_HUMAN	hypothetical protein LOC387638	52										ovary(3)|pancreas(1)	4						TTCATGTCTGGAATGTACATT	0.443000													31	106					0	0	0	0
FAM35B2	439965	broad.mit.edu	37	10	47380314	47380314	+	RNA	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr10:47380314G>C	uc010qfz.1	+	1		c.595G>C				NR_027634				Homo sapiens cDNA FLJ59018 complete cds, highly similar to Protein FAM35A.												0						GGTACAAAGAGAGTGTGTGCC	0.378000													10	42					0	0	0	0
CYP26A1	1592	broad.mit.edu	37	10	94834671	94834671	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr10:94834671C>T	uc001kil.2	+	3	595	c.550C>T	c.(550-552)CTC>TTC	p.L184F	CYP26A1_uc001kik.1_Missense_Mutation_p.L115F|CYP26A1_uc001kim.1_Missense_Mutation_p.L82F	NM_000783	NP_000774	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A,	184					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		Colorectal(252;0.122)				GGTGAAGCGCCTCATGTTCCG	0.652000													3	105					0	0	0	0
TM9SF3	56889	broad.mit.edu	37	10	98312702	98312702	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr10:98312702C>T	uc001kmm.3	-	6	992	c.775G>A	c.(775-777)GAA>AAA	p.E259K	TM9SF3_uc010qot.1_Missense_Mutation_p.E259K|TM9SF3_uc001kmn.1_Missense_Mutation_p.E28K	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor	259						integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		TCCATTTCTTCCTCTTTACTG	0.294000													16	45					0	0	0	0
FAM196A	642938	broad.mit.edu	37	10	128974488	128974488	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr10:128974488C>A	uc001lju.1	-	1	213	c.172G>T	c.(172-174)GAG>TAG	p.E58*	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Nonsense_Mutation_p.E58*|FAM196A_uc001ljv.1_Nonsense_Mutation_p.E58*|FAM196A_uc009yap.1_Nonsense_Mutation_p.E58*	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	58										ovary(2)	2						TCCCTCTGCTCATTCTGTGCC	0.587000													56	187					4.00338e-15	4.33536e-15	1	0
LOC653544	653544	broad.mit.edu	37	10	135491125	135491125	+	Missense_Mutation	SNP	G	A	A	rs140402194	by1000genomes	TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr10:135491125G>A	uc010qvi.1	+	1	847	c.736G>A	c.(736-738)GCG>ACG	p.A246T		NM_001127389	NP_001120861	F5GZ66	F5GZ66_HUMAN	double homeobox, 4-like	246						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCACACCGGCGCGTGGGGAAC	0.781000													3	16					0	0	0	0
OR52B6	340980	broad.mit.edu	37	11	5602923	5602923	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:5602923C>A	uc010qzi.1	+	1	817	c.817C>A	c.(817-819)CCT>ACT	p.P273T	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	273	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTCTATGTCCCTGCGCTTTT	0.517000													54	233					1.91123e-38	2.14289e-38	1	0
DNHD1	144132	broad.mit.edu	37	11	6540999	6540999	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:6540999C>T	uc001mdw.3	+	8	2126	c.1562C>T	c.(1561-1563)GCC>GTC	p.A521V	DNHD1_uc001mdp.2_Missense_Mutation_p.A521V|DNHD1_uc001mdq.2_Missense_Mutation_p.A210V	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	521					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GGAAAGTTTGCCCGCCTGGTT	0.522000													4	101					0	0	0	0
IPO7	10527	broad.mit.edu	37	11	9430055	9430055	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:9430055G>C	uc001mho.2	+	3	331	c.189G>C	c.(187-189)ATG>ATC	p.M63I		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	63	Importin N-terminal.				interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TGAAAAATATGATAACACAGT	0.363000													20	59					0	0	0	0
EIF4G2	1982	broad.mit.edu	37	11	10821202	10821202	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:10821202T>C	uc001mjc.2	-	19	2638	c.2221A>G	c.(2221-2223)ATA>GTA	p.I741V	EIF4G2_uc001mjb.2_Missense_Mutation_p.I535V|EIF4G2_uc009ygf.2_Missense_Mutation_p.I535V|EIF4G2_uc001mjd.2_Missense_Mutation_p.I703V	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	741	W2.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		TCCAACTTTATTTGCTTCAAC	0.368000													43	127					0	0	0	0
CYP2R1	120227	broad.mit.edu	37	11	14902248	14902248	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:14902248C>G	uc001mlr.2	-	3	434	c.434G>C	c.(433-435)CGA>CCA	p.R145P	CYP2R1_uc001mlo.2_Intron|CYP2R1_uc001mlp.2_Missense_Mutation_p.R28P|CYP2R1_uc001mlq.2_RNA|CYP2R1_uc001mls.1_Missense_Mutation_p.R90P	NM_024514	NP_078790	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R,	145					hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			ovary(1)|central_nervous_system(1)	2					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	TCCAAAATATCGAAAACTGTT	0.318000													12	58					0	0	0	0
PRG2	5553	broad.mit.edu	37	11	57155245	57155245	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:57155245C>T	uc001njz.2	-	4	619	c.592G>A	c.(592-594)GTG>ATG	p.V198M	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Missense_Mutation_p.V198M|PRG2_uc001nkb.2_Missense_Mutation_p.V198M|PRG2_uc001nkd.2_Missense_Mutation_p.V187M|PRG2_uc001nkc.2_Missense_Mutation_p.V198M|PRG2_uc001nke.2_Missense_Mutation_p.V478M	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	198	C-type lectin.				defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	CACAGGGCCACGCAGTGACCA	0.617000													3	14					0	0	0	0
OR10W1	81341	broad.mit.edu	37	11	58034971	58034971	+	Silent	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:58034971C>T	uc001nmq.1	-	1	762	c.360G>A	c.(358-360)CCG>CCA	p.P120P		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				GGTACTGCAACGGGTGGCAAA	0.532000													9	36					0	0	0	0
MRGPRF	116535	broad.mit.edu	37	11	68772961	68772961	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:68772961C>T	uc001ooo.3	-	3	1184	c.817G>A	c.(817-819)GAG>AAG	p.E273K	MRGPRF_uc001oop.3_Missense_Mutation_p.E273K	NM_001098515	NP_001091985	Q96AM1	MRGRF_HUMAN	MAS-related GPR, member F	273	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GTGACGTACTCGGGGAAGGGG	0.612000													4	7					0	0	0	0
DYNC2H1	79659	broad.mit.edu	37	11	102988581	102988581	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:102988581C>T	uc001pho.2	+	6	1132	c.988C>T	c.(988-990)CGC>TGC	p.R330C	DYNC2H1_uc001phn.1_Missense_Mutation_p.R330C|DYNC2H1_uc009yxe.1_Missense_Mutation_p.R330C	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	330	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		ACTTGGCAAACGCCTTGAAGA	0.333000													9	38					0	0	0	0
PHLDB1	23187	broad.mit.edu	37	11	118506147	118506147	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:118506147G>C	uc001ptr.1	+	11	2769	c.2416G>C	c.(2416-2418)GAG>CAG	p.E806Q	PHLDB1_uc001pts.2_Missense_Mutation_p.E806Q|PHLDB1_uc001ptt.2_Missense_Mutation_p.E806Q|PHLDB1_uc001ptu.1_RNA|PHLDB1_uc001ptv.1_Missense_Mutation_p.E606Q|PHLDB1_uc001ptw.1_Missense_Mutation_p.E208Q|PHLDB1_uc009zai.1_5'UTR|PHLDB1_uc001ptx.1_5'UTR	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	806	Potential.										0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		AAAGCTCTTTGAGGACTTGGA	0.637000													46	149					0	0	0	0
ANO2	57101	broad.mit.edu	37	12	5941701	5941701	+	Silent	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:5941701C>T	uc001qnm.2	-	5	762	c.690G>A	c.(688-690)TCG>TCA	p.S230S		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	235	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						GCTGCAGGTGCGAGCTCAGCT	0.507000													18	101					0	0	0	0
IFFO1	25900	broad.mit.edu	37	12	6659915	6659915	+	Silent	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:6659915C>T	uc001qpd.1	-	3	910	c.876G>A	c.(874-876)CTG>CTA	p.L292L	IFFO1_uc001qoy.2_RNA|IFFO1_uc001qpa.1_5'Flank|IFFO1_uc001qpb.1_5'Flank|IFFO1_uc001qpe.1_RNA|IFFO1_uc010sfe.1_Silent_p.L292L|IFFO1_uc001qpf.1_Silent_p.L292L|IFFO1_uc001qoz.1_5'Flank|IFFO1_uc001qpc.1_Silent_p.L292L|IFFO1_uc001qpg.2_5'Flank	NM_080730	NP_542768	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan isoform 2	292	Potential.					intermediate filament					0						GTTCCACCTTCAGTGCCAGCT	0.582000													31	51					0	0	0	0
FAM90A1	55138	broad.mit.edu	37	12	8374610	8374610	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:8374610G>A	uc001qui.2	-	7	1762	c.1203C>T	c.(1201-1203)AAC>AAT	p.N401N	FAM90A1_uc001quh.2_Silent_p.N401N	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	401							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		TCCAGCGTCCGTTTTCCAGTC	0.622000													15	41					0	0	0	0
LRP6	4040	broad.mit.edu	37	12	12284775	12284775	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:12284775G>A	uc001rah.3	-	18	4092	c.3950C>T	c.(3949-3951)TCA>TTA	p.S1317L	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.S1272L	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1317	LDL-receptor class A 2.|Extracellular (Potential).				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				CTTCTCATCTGATTTGTCCTG	0.448000													38	150					0	0	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18473914	18473914	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:18473914C>G	uc001rdt.2	+	7	1272	c.1156C>G	c.(1156-1158)CAG>GAG	p.Q386E	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.Q386E|PIK3C2G_uc010sic.1_Missense_Mutation_p.Q164E	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	386					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GGACCACAGTCAGTTTTATCT	0.333000													6	34					0	0	0	0
RECQL	5965	broad.mit.edu	37	12	21626554	21626554	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:21626554G>C	uc001rex.2	-	13	1726	c.1378C>G	c.(1378-1380)CAA>GAA	p.Q460E	RECQL_uc001rey.2_Missense_Mutation_p.Q460E	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	460					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						TCAAAATGTTGAGCCATCAAC	0.323000								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					17	57					0	0	0	0
RAP1B	5908	broad.mit.edu	37	12	69042539	69042539	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:69042539G>A	uc001sub.2	+	2	198	c.35G>A	c.(34-36)CGA>CAA	p.R12Q	RAP1B_uc010ste.1_Intron|RAP1B_uc001suc.2_Missense_Mutation_p.G12E|RAP1B_uc010stf.1_Missense_Mutation_p.G12E|RAP1B_uc010stg.1_Missense_Mutation_p.G12E|RAP1B_uc010sth.1_Missense_Mutation_p.G12E|RAP1B_uc010sti.1_Missense_Mutation_p.G12E	NM_001089704	NP_001083173	P61224	RAP1B_HUMAN	SubName: Full=Ras-related protein Rap-1A; SubName: Full=cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA; SubName: Full=RAP1A, member of RAS oncogene family;	12	GTP.				blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding				0	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)		CTTGGCTCAGGAGGCGTTGGA	0.363000													27	46					0	0	0	0
CPM	1368	broad.mit.edu	37	12	69250409	69250409	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:69250409C>G	uc001sup.2	-	9	1201	c.1140G>C	c.(1138-1140)GAG>GAC	p.E380D	CPM_uc001sur.2_Missense_Mutation_p.E380D|CPM_uc001suq.2_Missense_Mutation_p.E380D	NM_198320	NP_938079	P14384	CBPM_HUMAN	carboxypeptidase M precursor	380					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding				0	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			TCTGGGATTTCTCCGGAATAA	0.408000													38	123					0	0	0	0
MYF6	4618	broad.mit.edu	37	12	81101864	81101864	+	Silent	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:81101864C>T	uc001szf.1	+	1	419	c.366C>T	c.(364-366)GCC>GCT	p.A122A		NM_002469	NP_002460	P23409	MYF6_HUMAN	myogenic factor 6	122	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						GAACTGTGGCCAACCCCAACC	0.617000													15	103					0	0	0	0
TMTC3	160418	broad.mit.edu	37	12	88589182	88589182	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:88589182C>G	uc001tau.2	+	14	2721	c.2501C>G	c.(2500-2502)TCA>TGA	p.S834*		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	835						integral to membrane	binding			skin(1)	1						AGTAAGATTTCAAGTGTGGAA	0.338000													97	120					0	0	0	0
USP44	84101	broad.mit.edu	37	12	95927270	95927270	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:95927270G>A	uc001teg.2	-	2	907	c.763C>T	c.(763-765)CAA>TAA	p.Q255*	USP44_uc001teh.2_Nonsense_Mutation_p.Q255*|USP44_uc009zte.2_Nonsense_Mutation_p.Q252*	NM_001042403	NP_001035862	Q9H0E7	UBP44_HUMAN	ubiquitin thiolesterase 44	255					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3						CTGACTTTTTGAGATATTTCA	0.388000													32	206					0	0	0	0
ANO4	121601	broad.mit.edu	37	12	101477507	101477507	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:101477507A>G	uc010svm.1	+	16	2019	c.1447A>G	c.(1447-1449)AAT>GAT	p.N483D	ANO4_uc001thw.2_Missense_Mutation_p.N448D|ANO4_uc001thx.2_Missense_Mutation_p.N483D|ANO4_uc001thy.2_Intron	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	483	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						AGAGCGGATGAATCCAATTTC	0.383000										HNSCC(74;0.22)			36	178					0	0	0	0
SYCP3	50511	broad.mit.edu	37	12	102127427	102127427	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:102127427G>C	uc001tiq.2	-	6	511	c.379C>G	c.(379-381)CAG>GAG	p.Q127E	SYCP3_uc001tir.2_Missense_Mutation_p.Q127E|SYCP3_uc001tis.2_Missense_Mutation_p.Q127E	NM_153694	NP_710161	Q8IZU3	SYCP3_HUMAN	synaptonemal complex protein 3	127	Gln-rich.				cell division|male meiosis I|spermatogenesis, exchange of chromosomal proteins	nucleus	DNA binding				0						AGAAACTGCTGAGAATATTCT	0.303000													57	79					0	0	0	0
MED13L	23389	broad.mit.edu	37	12	116457051	116457051	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:116457051G>A	uc001tvw.2	-	7	1042	c.987C>T	c.(985-987)ACC>ACT	p.T329T		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	329					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GTTCTGGAGAGGTGGGAGGGG	0.542000													16	84					0	0	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751261	19751261	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr13:19751261C>T	uc009zzj.2	-	4	911	c.862G>A	c.(862-864)GTG>ATG	p.V288M		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	288					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		ATCTCAGCCACGGACAGCTGC	0.607000													43	137					0	0	0	0
TNFSF11	8600	broad.mit.edu	37	13	43180976	43180976	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr13:43180976G>A	uc001uyu.2	+	5	1025	c.876G>A	c.(874-876)GAG>GAA	p.E292E	TNFSF11_uc001uyt.2_Silent_p.E219E	NM_003701	NP_003692	O14788	TNF11_HUMAN	tumor necrosis factor ligand superfamily, member	292	Extracellular (Potential).				immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding				0		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		TCAGCATCGAGGTCTCCAACC	0.423000													53	178					0	0	0	0
MYH7	4625	broad.mit.edu	37	14	23898464	23898464	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr14:23898464C>T	uc001wjx.2	-	13	1337	c.1231G>A	c.(1231-1233)GTC>ATC	p.V411I		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	411	Myosin head-like.		V -> I (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CCCTTGGTGACGTACTCATTG	0.567000													145	91					0	0	0	0
FAM179B	23116	broad.mit.edu	37	14	45432126	45432126	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr14:45432126G>A	uc001wvv.2	+	1	711	c.502G>A	c.(502-504)GAG>AAG	p.E168K	FAM179B_uc001wvw.2_Missense_Mutation_p.E168K|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.E168K|FAM179B_uc001wvu.2_Missense_Mutation_p.E168K	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	168							binding			skin(2)|upper_aerodigestive_tract(1)	3						GGGTCAGGGGGAGGCAGGCCA	0.562000													157	102					0	0	0	0
SGPP1	81537	broad.mit.edu	37	14	64153029	64153029	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr14:64153029C>G	uc001xgj.2	-	3	1214	c.1120G>C	c.(1120-1122)GTA>CTA	p.V374L		NM_030791	NP_110418	Q9BX95	SGPP1_HUMAN	sphingosine-1-phosphate phosphatase 1	374	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0056)|all cancers(60;0.0141)|BRCA - Breast invasive adenocarcinoma(234;0.103)		AGTACAAATACCATCCCTATG	0.383000													96	222					0	0	0	0
C14orf102	55051	broad.mit.edu	37	14	90770702	90770702	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr14:90770702G>A	uc001xyi.1	-	5	613	c.582C>T	c.(580-582)TGC>TGT	p.C194C	C14orf102_uc010atp.1_5'UTR|C14orf102_uc001xyj.1_5'UTR	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	194	Potential.						protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		TAATGCCAAGGCAGGAGTCTC	0.418000													23	136					0	0	0	0
HHIPL1	84439	broad.mit.edu	37	14	100119154	100119154	+	Silent	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr14:100119154C>T	uc010avs.2	+	2	914	c.849C>T	c.(847-849)AGC>AGT	p.S283S	HHIPL1_uc001ygl.1_Silent_p.S283S	NM_001127258	NP_001120730	Q96JK4	HIPL1_HUMAN	HHIP-like protein 1 isoform a	283					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			skin(2)	2		Melanoma(154;0.128)				TCCGCATCAGCGAGTTCAGAG	0.617000													18	53					0	0	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102509076	102509076	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr14:102509076G>A	uc001yks.2	+	69	12668	c.12504G>A	c.(12502-12504)CGG>CGA	p.R4168R		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4168	AAA 6 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CCGTCTCACGGATATGCAAGG	0.577000													47	45					0	0	0	0
TJP1	7082	broad.mit.edu	37	15	30018667	30018667	+	Silent	SNP	A	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr15:30018667A>G	uc001zcr.2	-	18	2803	c.2328T>C	c.(2326-2328)AAT>AAC	p.N776N	TJP1_uc010azl.2_Silent_p.N764N|TJP1_uc001zcq.2_Silent_p.N780N|TJP1_uc001zcs.2_Silent_p.N776N	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	776	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		CATTCATTGAATTTAAGTTAA	0.373000													33	88					0	0	0	0
SLC28A2	9153	broad.mit.edu	37	15	45564978	45564978	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr15:45564978C>G	uc001zva.2	+	17	1920	c.1855C>G	c.(1855-1857)CAG>GAG	p.Q619E		NM_004212	NP_004203	O43868	S28A2_HUMAN	solute carrier family 28 (sodium-coupled	619					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		AGGGCTCTTTCAGAGGTGAGC	0.522000													22	51					0	0	0	0
UNC13C	440279	broad.mit.edu	37	15	54305667	54305667	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr15:54305667G>C	uc002ack.2	+	1	567	c.567G>C	c.(565-567)AAG>AAC	p.K189N		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	189					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AATGGAAAAAGAGTCAAGAAT	0.458000													30	90					0	0	0	0
IDH3A	3419	broad.mit.edu	37	15	78454629	78454629	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr15:78454629G>A	uc002bdd.2	+	6	558	c.531G>A	c.(529-531)AAG>AAA	p.K177K	IDH3A_uc010umt.1_Silent_p.K142K|IDH3A_uc010umu.1_Silent_p.K68K|IDH3A_uc002bde.2_Silent_p.K127K|IDH3A_uc010umv.1_Silent_p.K127K|IDH3A_uc002bdf.2_Silent_p.K28K|IDH3A_uc002bdg.2_Silent_p.K90K	NM_005530	NP_005521	P50213	IDH3A_HUMAN	isocitrate dehydrogenase 3 (NAD+) alpha	177					carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)	GGGCGAGCAAGCGCATTGCTG	0.562000													31	118					0	0	0	0
KIF22	3835	broad.mit.edu	37	16	29811084	29811084	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:29811084G>A	uc002dts.3	+	7	1150	c.1126G>A	c.(1126-1128)GAG>AAG	p.E376K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KIF22_uc010vdv.1_Missense_Mutation_p.E308K|KIF22_uc010vdw.1_Missense_Mutation_p.E308K|KIF22_uc010bzf.2_Missense_Mutation_p.E308K	NM_007317	NP_015556	Q14807	KIF22_HUMAN	kinesin family member 22	376					blood coagulation|DNA repair|microtubule-based movement|mitosis	cytosol|kinetochore|microtubule|nucleus	ATP binding|DNA binding|microtubule motor activity|protein binding				0						TTTTACCAATGAGAGCCTGCA	0.532000													13	35					0	0	0	0
ITGAD	3681	broad.mit.edu	37	16	31404708	31404708	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:31404708G>A	uc002ebv.1	+	1	76	c.27G>A	c.(25-27)CTG>CTA	p.L9L	ITGAD_uc010vfl.1_Silent_p.L9L|ITGAD_uc010cap.1_Silent_p.L9L	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	9					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						TGCTTCTTCTGAGTGGTAAGT	0.627000													62	159					0	0	0	0
PHKB	5257	broad.mit.edu	37	16	47694703	47694703	+	Silent	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:47694703C>G	uc002eev.3	+	22	2221	c.2169C>G	c.(2167-2169)CCC>CCG	p.P723P	PHKB_uc002eeu.3_Silent_p.P716P	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	723					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				AGGACAAACCCACCCACGAAA	0.488000													28	137					0	0	0	0
NUP93	9688	broad.mit.edu	37	16	56878443	56878443	+	Silent	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:56878443C>G	uc002eka.2	+	22	2503	c.2382C>G	c.(2380-2382)ACC>ACG	p.T794T	NUP93_uc002ekb.2_Silent_p.T671T|NUP93_uc010vhi.1_Silent_p.T671T	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	794					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						CTCTGATTACCTTTGCTGGAA	0.498000													27	38					0	0	0	0
NFAT5	10725	broad.mit.edu	37	16	69681025	69681025	+	Silent	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:69681025C>T	uc002exm.1	+	3	1502	c.294C>T	c.(292-294)ACC>ACT	p.T98T	NFAT5_uc002exh.1_Missense_Mutation_p.P32L|NFAT5_uc002exi.2_Silent_p.T22T|NFAT5_uc002exj.1_Silent_p.T22T|NFAT5_uc002exk.1_Silent_p.T22T|NFAT5_uc002exl.1_Silent_p.T116T|NFAT5_uc002exn.1_Silent_p.T116T	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	98	Ser-rich.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						CCTCAGTCACCGACAGCAAGG	0.532000													96	302					0	0	0	0
BCMO1	53630	broad.mit.edu	37	16	81295760	81295760	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:81295760C>G	uc002fgn.1	+	4	561	c.343C>G	c.(343-345)CAC>GAC	p.H115D	BCMO1_uc002fgm.1_Missense_Mutation_p.H115D|BCMO1_uc010vnp.1_Missense_Mutation_p.H46D	NM_017429	NP_059125	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase	115					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0						CTACTTGTCTCACACCATCCC	0.468000													67	176					0	0	0	0
OSGIN1	29948	broad.mit.edu	37	16	83983085	83983085	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:83983085C>T	uc002fha.2	+	1	414	c.31C>T	c.(31-33)CGG>TGG	p.R11W	OSGIN1_uc002fhb.2_5'UTR	NM_013370	NP_037502	Q9UJX0	OSGI1_HUMAN	oxidative stress induced growth inhibitor 1	11					cell differentiation|multicellular organismal development|negative regulation of cell growth		growth factor activity				0						AGGCTGCTGCCGGGGAAATAT	0.582000													42	84					0	0	0	0
FBXO31	79791	broad.mit.edu	37	16	87367628	87367628	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:87367628C>T	uc002fjw.2	-	8	1305	c.1261G>A	c.(1261-1263)GGT>AGT	p.G421S	FBXO31_uc010vot.1_Missense_Mutation_p.G249S|FBXO31_uc002fjv.2_Missense_Mutation_p.G313S	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	421					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		CCATCCTCACCAGGTGTCCCA	0.746000													8	29					0	0	0	0
RPA1	6117	broad.mit.edu	37	17	1747221	1747221	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:1747221G>A	uc002fto.2	+	3	207	c.92G>A	c.(91-93)CGT>CAT	p.R31H		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	31					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						TAGAACATCCGTCCCATTACT	0.488000								NER					24	105					0	0	0	0
ITGAE	3682	broad.mit.edu	37	17	3658514	3658514	+	Silent	SNP	G	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:3658514G>T	uc002fwo.3	-	12	1380	c.1281C>A	c.(1279-1281)TCC>TCA	p.S427S		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	427	FG-GAP 3.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		ACGCCCCTCCGGACCAGTCAA	0.721000													3	2					0.004672	0.004736	1	0
C17orf74	201243	broad.mit.edu	37	17	7329025	7329025	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:7329025G>A	uc002ggw.2	+	1	91	c.18G>A	c.(16-18)TGG>TGA	p.W6*	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	6						integral to membrane					0		Prostate(122;0.157)				ACCAGCTATGGCATAACACCG	0.592000													65	170					0	0	0	0
MYH13	8735	broad.mit.edu	37	17	10219279	10219279	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:10219279C>T	uc002gmk.1	-	28	3892	c.3802G>A	c.(3802-3804)GAG>AAG	p.E1268K		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1268	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GTCTGTTGCTCGTCCTTGGCT	0.463000													48	156					0	0	0	0
MYH13	8735	broad.mit.edu	37	17	10231210	10231210	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:10231210C>G	uc002gmk.1	-	22	2754	c.2664G>C	c.(2662-2664)AAG>AAC	p.K888N		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	888	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GGAGGTCATTCTTCTCCTGCA	0.527000											OREG0024177	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	75					0	0	0	0
MYH13	8735	broad.mit.edu	37	17	10231229	10231229	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:10231229A>T	uc002gmk.1	-	22	2735	c.2645T>A	c.(2644-2646)GTC>GAC	p.V882D		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	882	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CAGGAGGGAGACCATTTTCTC	0.527000											OREG0024177	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	74					0	0	0	0
MYO15A	51168	broad.mit.edu	37	17	18022599	18022599	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:18022599G>A	uc010vxh.1	+	2	823	c.485G>A	c.(484-486)CGC>CAC	p.R162H		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	162	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TGGCTGCAGCGCTCGAGCTCC	0.677000													11	65					0	0	0	0
NOS2	4843	broad.mit.edu	37	17	26101285	26101285	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:26101285G>T	uc002gzu.2	-	12	1738	c.1474C>A	c.(1474-1476)CAG>AAG	p.Q492K	NOS2_uc010crh.1_Missense_Mutation_p.Q492K|NOS2_uc010wab.1_Missense_Mutation_p.Q492K	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	492					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CCCCTAACCTGATAGTAGTAG	0.547000													11	31					7.03913e-09	7.33655e-09	1	0
ABHD15	116236	broad.mit.edu	37	17	27889909	27889909	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:27889909G>A	uc002hed.1	-	2	1141	c.1077C>T	c.(1075-1077)GAC>GAT	p.D359D		NM_198147	NP_937790	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15 precursor	359						extracellular region	carboxylesterase activity				0						ACACGGGGTCGTCAGCACTGC	0.602000													12	101					0	0	0	0
SSH2	85464	broad.mit.edu	37	17	27959836	27959836	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:27959836C>G	uc002heo.1	-	15	2295	c.2295G>C	c.(2293-2295)CAG>CAC	p.Q765H	SSH2_uc010wbh.1_Missense_Mutation_p.Q792H	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	765					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TCAGTTGAATCTGCCCAACTC	0.468000													36	63					0	0	0	0
KRT12	3859	broad.mit.edu	37	17	39019389	39019389	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:39019389G>A	uc002hvk.2	-	6	1326	c.1302C>T	c.(1300-1302)GAC>GAT	p.D434D		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	434	Rod.|Coil 2.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				GGGCCTCCCCGTCCAGCAGGC	0.612000													19	67					0	0	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40842782	40842782	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:40842782G>A	uc002iay.2	+	13	2097	c.1881G>A	c.(1879-1881)CGG>CGA	p.R627R	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	627	Extracellular (Potential).|Fibrinogen C-terminal.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		CAGTTGTGCGGCATGACAGGC	0.587000													4	209					0	0	0	0
HOXB4	3214	broad.mit.edu	37	17	46654222	46654222	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:46654222G>C	uc002inp.2	-	2	680	c.618C>G	c.(616-618)ATC>ATG	p.I206M	HOXB3_uc010wlm.1_Intron|HOXB3_uc010dbf.2_Intron|HOXB3_uc010dbg.2_Intron|HOXB3_uc002ino.2_5'Flank|HOXB3_uc010wlk.1_5'Flank|HOXB3_uc010wll.1_Intron	NM_024015	NP_076920	P17483	HXB4_HUMAN	homeobox B4	206	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ACCAGATCTTGATCTGGCGCT	0.607000													62	215					0	0	0	0
CARD14	79092	broad.mit.edu	37	17	78182030	78182030	+	Silent	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:78182030C>T	uc002jxw.1	+	21	3096	c.2901C>T	c.(2899-2901)TAC>TAT	p.Y967Y	CARD14_uc002jxt.1_RNA	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	967	Guanylate kinase-like.				activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CCTGTCTATACAGCAGCCTGG	0.672000													2	2					0	0	0	0
ZNF521	25925	broad.mit.edu	37	18	22805215	22805215	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr18:22805215G>A	uc002kvk.2	-	4	2914	c.2667C>T	c.(2665-2667)GAC>GAT	p.D889D	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.D889D|ZNF521_uc002kvl.2_Silent_p.D669D	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	889	C2H2-type 21; degenerate.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CCCCACAAATGTCGCAGCCGT	0.522000			T	PAX5	ALL								27	67					0	0	0	0
ASXL3	80816	broad.mit.edu	37	18	31319619	31319619	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr18:31319619G>C	uc010dmg.1	+	11	2306	c.2251G>C	c.(2251-2253)GAA>CAA	p.E751Q	ASXL3_uc002kxq.2_Missense_Mutation_p.E458Q	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	751	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						ACTTCCTTCAGAAACATCTCC	0.433000													82	230					0	0	0	0
KIAA1468	57614	broad.mit.edu	37	18	59888730	59888730	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr18:59888730G>A	uc002lil.2	+	5	1073	c.858G>A	c.(856-858)CAG>CAA	p.Q286Q	KIAA1468_uc002lik.1_Silent_p.Q286Q|KIAA1468_uc010xel.1_Silent_p.Q286Q|KIAA1468_uc002lim.2_5'UTR	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	286	LisH.						binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				ACGATGATCAGGTAAAGTTAC	0.234000													14	51					0	0	0	0
SALL3	27164	broad.mit.edu	37	18	76754267	76754267	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr18:76754267G>A	uc002lmt.2	+	2	2276	c.2276G>A	c.(2275-2277)CGC>CAC	p.R759H	SALL3_uc010dra.2_Missense_Mutation_p.R366H	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	759	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CAGCACATCCGCATGCACATG	0.657000													13	45					0	0	0	0
CRB3	92359	broad.mit.edu	37	19	6466612	6466612	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:6466612G>A	uc002mey.2	+	4	823	c.292G>A	c.(292-294)GAG>AAG	p.E98K	CRB3_uc002mez.2_Missense_Mutation_p.E98K|CRB3_uc002mfa.2_Missense_Mutation_p.E98K	NM_139161	NP_631900	Q9BUF7	CRUM3_HUMAN	crumbs 3 isoform a precursor	98	Cytoplasmic (Potential).				protein localization in plasma membrane|tight junction assembly	apical plasma membrane|integral to membrane|tight junction	SH3 domain binding				0						GCCCAGTAGCGAGGAGCAGGT	0.677000													21	80					0	0	0	0
OR7G1	125962	broad.mit.edu	37	19	9226035	9226035	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:9226035G>A	uc002mks.1	-	1	405	c.405C>T	c.(403-405)CTC>CTT	p.L135L		NM_001005192	NP_001005192	Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G,	135	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						GGACATTCATGAGGACTGTGT	0.493000													28	98					0	0	0	0
ZNF844	284391	broad.mit.edu	37	19	12187275	12187275	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:12187275G>C	uc002mtb.2	+	4	1483	c.1340G>C	c.(1339-1341)CGT>CCT	p.R447P	ZNF844_uc010dym.1_Missense_Mutation_p.R290P	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	447					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGAGAAACCGTATGAGTGTA	0.433000													3	147					0	0	0	0
OR10H1	26539	broad.mit.edu	37	19	15918182	15918182	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:15918182G>A	uc002nbq.2	-	1	755	c.666C>T	c.(664-666)ATC>ATT	p.I222I		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGGCGGCCACGATGAAGGCAT	0.577000													18	101					0	0	0	0
MAST3	23031	broad.mit.edu	37	19	18254654	18254654	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:18254654G>A	uc002nhz.3	+	21	2334	c.2334G>A	c.(2332-2334)CTG>CTA	p.L778L		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	778							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						CATCTCTCCTGAATACCATCA	0.607000													10	26					0	0	0	0
TMEM161A	54929	broad.mit.edu	37	19	19230817	19230817	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:19230817G>A	uc002nlg.2	-	12	1392	c.1362C>T	c.(1360-1362)CTC>CTT	p.L454L	TMEM161A_uc010eca.2_RNA|TMEM161A_uc002nlh.2_Silent_p.L429L|TMEM161A_uc002nli.2_Silent_p.L351L|TMEM161A_uc002nlj.2_Silent_p.L329L	NM_017814	NP_060284	Q9NX61	T161A_HUMAN	transmembrane protein 161A precursor	454	Helical; (Potential).				cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)	2			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			TCCACCAGATGAGGTAGGCCA	0.662000													4	7					0	0	0	0
FCGBP	8857	broad.mit.edu	37	19	40392591	40392591	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:40392591C>T	uc002omp.3	-	16	7921	c.7913G>A	c.(7912-7914)GGG>GAG	p.G2638E		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	2638	VWFD 6.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCCCTCGCTCCCCGGCGGGCA	0.667000													19	66					0	0	0	0
PSG6	5675	broad.mit.edu	37	19	43530465	43530465	+	Silent	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:43530465G>C	uc002ovh.1	-	1	167	c.78C>G	c.(76-78)CTC>CTG	p.L26L	PSG11_uc002ouw.2_Silent_p.L26L|PSG10_uc002ouv.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Silent_p.L26L|PSG11_uc002ovm.1_Silent_p.L20L|PSG11_uc002ovn.1_Silent_p.L26L|PSG11_uc002ovo.1_Silent_p.L20L|PSG11_uc002ovp.1_Silent_p.L20L			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	20					female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				CCTCACCTGTGAGCAGGAGCC	0.562000													46	204					0	0	0	0
ZNF283	284349	broad.mit.edu	37	19	44341279	44341279	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:44341279G>A	uc002oxr.3	+	6	553	c.285G>A	c.(283-285)AGG>AGA	p.R95R	ZNF283_uc002oxp.3_Intron	NM_181845	NP_862828	Q8N7M2	ZN283_HUMAN	zinc finger protein 283	95	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				CTGCTCAGAGGGACTTGTACG	0.463000													39	86					0	0	0	0
PPP5C	5536	broad.mit.edu	37	19	46891915	46891915	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:46891915G>A	uc002pem.2	+	11	1342	c.1282G>A	c.(1282-1284)GAA>AAA	p.E428K	PPP5C_uc010xya.1_Missense_Mutation_p.E295K|PPP5C_uc002pen.2_Missense_Mutation_p.E406K	NM_006247	NP_006238	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	428	Catalytic.				mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			lung(1)|pancreas(1)	2		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)		CCGCAGCCACGAAGTCAAGGC	0.597000													48	160					0	0	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49368815	49368815	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:49368815G>A	uc002pkx.2	-	3	688	c.137C>T	c.(136-138)GCG>GTG	p.A46V	PLEKHA4_uc010eml.2_Missense_Mutation_p.A46V	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	46						cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		CCTCCTGAGCGCATTGCCTCT	0.572000													14	53					0	0	0	0
LILRA4	23547	broad.mit.edu	37	19	54849916	54849916	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr19:54849916C>T	uc002qfj.2	-	3	163	c.106G>A	c.(106-108)GGT>AGT	p.G36S	LILRA4_uc002qfi.2_5'UTR	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	36	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		ATCACGGGACCTGGCTCGGCC	0.572000											OREG0003656	type=REGULATORY REGION|Gene=LILRA4|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	37	93					0	0	0	0
FAM84A	151354	broad.mit.edu	37	2	14774194	14774194	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:14774194G>A	uc002rbz.1	+	2	333	c.91G>A	c.(91-93)GTC>ATC	p.V31I	FAM84A_uc002rca.1_5'Flank	NM_145175	NP_660158	Q96KN4	FA84A_HUMAN	family with sequence similarity 84, member A	31										pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(1;0.00969)			CGAACTGCGGGTCGGGGTTGC	0.617000													3	56					0	0	0	0
ITSN2	50618	broad.mit.edu	37	2	24521584	24521584	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:24521584C>A	uc002rfe.2	-	13	1702	c.1444G>T	c.(1444-1446)GTC>TTC	p.V482F	ITSN2_uc002rff.2_Missense_Mutation_p.V482F|ITSN2_uc002rfg.2_Missense_Mutation_p.V482F|ITSN2_uc010eyd.2_Missense_Mutation_p.V507F	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	482	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTAACCTGACAATTTCTTCT	0.398000													36	135					4.11147e-13	4.43081e-13	1	0
DNMT3A	1788	broad.mit.edu	37	2	25467435	25467435	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:25467435G>A	uc002rgc.2	-	14	1898	c.1641C>T	c.(1639-1641)CTC>CTT	p.L547L	DNMT3A_uc002rgd.2_Silent_p.L547L|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Silent_p.L358L	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	547	PHD-type; atypical.|Interaction with the PRC2/EED-EZH2 complex (By similarity).|ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCCGCACATGAGCACCTCAC	0.632000			Mis|F|N|S		AML								15	49					0	0	0	0
KRTCAP3	200634	broad.mit.edu	37	2	27665758	27665758	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:27665758G>T	uc002rks.2	+	3	280	c.263G>T	c.(262-264)CGC>CTC	p.R88L	KRTCAP3_uc010ylr.1_Missense_Mutation_p.R88L|KRTCAP3_uc002rkt.2_Missense_Mutation_p.R70L	NM_173853	NP_776252	Q53RY4	KCP3_HUMAN	keratinocyte associated protein 3	88						integral to membrane					0	Acute lymphoblastic leukemia(172;0.155)					AACCTTCTTCGCCCTCCACTG	0.587000													27	54					7.68411e-24	8.48693e-24	1	0
MTA3	57504	broad.mit.edu	37	2	42909708	42909708	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:42909708C>A	uc002rso.1	+	10	1372	c.702C>A	c.(700-702)TTC>TTA	p.F234L	MTA3_uc002rsp.1_Missense_Mutation_p.F234L|MTA3_uc002rsq.2_Missense_Mutation_p.F290L|MTA3_uc002rsr.2_Missense_Mutation_p.F290L	NM_020744	NP_065795	Q9BTC8	MTA3_HUMAN	metastasis associated 1 family, member 3	290	SANT.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						GCAAAGACTTCAATGACATAC	0.363000													4	16					0.00024832	0.000254042	1	0
VRK2	7444	broad.mit.edu	37	2	58350334	58350334	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:58350334A>G	uc002rzo.2	+	11	1387	c.642A>G	c.(640-642)ATA>ATG	p.I214M	VRK2_uc010fcb.2_Missense_Mutation_p.I214M|VRK2_uc002rzs.2_Missense_Mutation_p.I214M|VRK2_uc002rzr.2_Missense_Mutation_p.I214M|VRK2_uc010fcc.2_Missense_Mutation_p.I96M|VRK2_uc002rzv.2_Missense_Mutation_p.I214M|VRK2_uc010fcd.2_Missense_Mutation_p.I191M|VRK2_uc002rzp.2_Missense_Mutation_p.I214M|VRK2_uc010ypg.1_Missense_Mutation_p.I214M|VRK2_uc002rzq.2_Missense_Mutation_p.I214M|VRK2_uc002rzu.2_Missense_Mutation_p.I214M|VRK2_uc002rzt.2_Missense_Mutation_p.I96M|VRK2_uc010yph.1_Missense_Mutation_p.I96M	NM_001130482	NP_001123954	Q86Y07	VRK2_HUMAN	vaccinia related kinase 2 isoform 2	214	Protein kinase.					integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						ATGGGACAATAGAGTTTACCA	0.383000													3	203					0	0	0	0
MOGS	7841	broad.mit.edu	37	2	74688809	74688809	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:74688809C>T	uc010ffj.2	-	4	2270	c.2107G>A	c.(2107-2109)GAC>AAC	p.D703N	MOGS_uc010ffh.2_Missense_Mutation_p.D428N|MOGS_uc010yrt.1_Missense_Mutation_p.D584N|MOGS_uc010ffi.2_Missense_Mutation_p.D597N	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	703	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						GAGGTGGGGTCCAGCAGTCGC	0.607000													28	72					0	0	0	0
Unknown	0	broad.mit.edu	37	2	90139282	90139282	+	RNA	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:90139282C>T	uc010fhm.2	+	18		c.2075C>T								Parts of antibodies, mostly variable regions.																		TTTCCAATCTCAGGTGCCAGA	0.453000													33	136					0	0	0	0
SEMA4C	54910	broad.mit.edu	37	2	97526459	97526459	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:97526459G>A	uc002sxh.3	-	15	2566	c.2406C>T	c.(2404-2406)CTC>CTT	p.L802L	ANKRD39_uc002sxd.3_5'Flank|SEMA4C_uc002sxf.3_Silent_p.L302L|SEMA4C_uc002sxe.2_Silent_p.L343L|SEMA4C_uc002sxg.3_Silent_p.L855L	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	802	Cytoplasmic (Potential).				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						GGGGGTGCCCGAGCCCTCCCC	0.627000													51	142					0	0	0	0
RBM43	375287	broad.mit.edu	37	2	152107860	152107860	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:152107860C>T	uc002txh.2	-	4	782	c.634G>A	c.(634-636)GAG>AAG	p.E212K		NM_198557	NP_940959	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	212							nucleotide binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(221;0.131)		CTAGCAGTCTCAGGTACTAAG	0.393000													48	127					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179427722	179427722	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:179427722C>T	uc010zfg.1	-	275	75657	c.75433G>A	c.(75433-75435)GAA>AAA	p.E25145K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E18840K|TTN_uc010zfi.1_Missense_Mutation_p.E18773K|TTN_uc010zfj.1_Missense_Mutation_p.E18648K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26072							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAATGCCTTCTGCCTTTTCC	0.438000													30	131					0	0	0	0
PDE1A	5136	broad.mit.edu	37	2	183129053	183129053	+	Missense_Mutation	SNP	C	G	G	rs149743969		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:183129053C>G	uc002uos.2	-	3	274	c.190G>C	c.(190-192)GAA>CAA	p.E64Q	PDE1A_uc010zfp.1_5'UTR|PDE1A_uc002uoq.1_Missense_Mutation_p.E64Q|PDE1A_uc010zfq.1_Missense_Mutation_p.E64Q|PDE1A_uc002uor.2_Missense_Mutation_p.E48Q|PDE1A_uc002uov.1_RNA	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	64					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TAAACTGCTTCCAGCACAGAT	0.378000													23	100					0	0	0	0
CASP8	841	broad.mit.edu	37	2	202151270	202151270	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:202151270C>T	uc002uxr.1	+	10	1602	c.1393C>T	c.(1393-1395)CAG>TAG	p.Q465*	CASP8_uc002uxp.1_Nonsense_Mutation_p.Q482*|CASP8_uc002uxq.1_Nonsense_Mutation_p.Q450*|CASP8_uc002uxt.1_Nonsense_Mutation_p.Q524*|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Nonsense_Mutation_p.Q450*|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Nonsense_Mutation_p.Q381*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	465					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						ACAGATGCCTCAGCCTACTTT	0.313000										HNSCC(4;0.00038)			36	40					0	0	0	0
ERBB4	2066	broad.mit.edu	37	2	212488710	212488710	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:212488710C>G	uc002veg.1	-	18	2237	c.2139G>C	c.(2137-2139)TTG>TTC	p.L713F	ERBB4_uc002veh.1_Missense_Mutation_p.L713F|ERBB4_uc010zji.1_Missense_Mutation_p.L703F|ERBB4_uc010zjj.1_Missense_Mutation_p.L703F|ERBB4_uc010fut.1_Missense_Mutation_p.L713F	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	713	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CAGTTTCTTTCAAAATACGAA	0.403000										TSP Lung(8;0.080)			24	71					0	0	0	0
ABCB6	10058	broad.mit.edu	37	2	220081144	220081144	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:220081144C>T	uc002vkc.1	-	4	1189	c.912G>A	c.(910-912)TGG>TGA	p.W304*	ABCB6_uc010fwe.1_Nonsense_Mutation_p.W258*|ABCB6_uc010zku.1_RNA	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	304	ABC transmembrane type-1.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGTAACAGTCCAGGCCAGAG	0.552000													18	95					0	0	0	0
SLC23A2	9962	broad.mit.edu	37	20	4850573	4850573	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr20:4850573G>T	uc002wlg.1	-	12	1604	c.1229C>A	c.(1228-1230)CCC>CAC	p.P410H	SLC23A2_uc010zqr.1_Missense_Mutation_p.P295H|SLC23A2_uc002wlh.1_Missense_Mutation_p.P410H|SLC23A2_uc002wli.2_Missense_Mutation_p.P409H	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	410					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						GTGGATGGGGGGGGGTGGGGC	0.542000													36	75					6.90743e-12	7.40796e-12	1	0
C20orf71	128861	broad.mit.edu	37	20	31812910	31812910	+	Silent	SNP	C	T	T	rs140343618	byFrequency	TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr20:31812910C>T	uc002wyr.2	+	4	601	c.393C>T	c.(391-393)TTC>TTT	p.F131F	C20orf71_uc002wys.2_Silent_p.F95F	NM_178466	NP_848561	Q9BQP9	SPLC3_HUMAN	short long palate, lung and nasal epithelium	131						extracellular region	lipid binding			ovary(1)|skin(1)	2						GCAGGTCCTTCGATAACAACA	0.383000													28	92					0	0	0	0
C20orf165	128497	broad.mit.edu	37	20	44515723	44515723	+	Silent	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr20:44515723C>T	uc002xqf.2	-	2	126	c.117G>A	c.(115-117)GTG>GTA	p.V39V		NM_080608	NP_542175	Q9BR10	CT165_HUMAN	chromosome 20 open reading frame 165	39						integral to membrane					0		Myeloproliferative disorder(115;0.0122)				CACCAGAGGCCACCACCACTG	0.607000													36	102					0	0	0	0
TPTE	7179	broad.mit.edu	37	21	10951321	10951321	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr21:10951321G>A	uc002yip.1	-	10	759	c.391C>T	c.(391-393)CTA>TTA	p.L131L	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Silent_p.L113L|TPTE_uc002yir.1_Silent_p.L93L|TPTE_uc010gkv.1_5'UTR	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	131	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCAATAGCTAGAGAAATAGAA	0.343000													24	80					0	0	0	0
CBR3	874	broad.mit.edu	37	21	37507579	37507579	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr21:37507579C>T	uc002yve.2	+	1	317	c.89C>T	c.(88-90)TCT>TTT	p.S30F	uc002yvc.1_Intron|uc002yvd.1_Intron	NM_001236	NP_001227	O75828	CBR3_HUMAN	carbonyl reductase 3	30	NADP.					cytosol|nucleus	carbonyl reductase (NADPH) activity|NADPH binding				0						CGACAGTTCTCTGGGGATGTG	0.726000													3	13					0	0	0	0
PCBP3	54039	broad.mit.edu	37	21	47350746	47350746	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr21:47350746G>C	uc002zhq.1	+	11	968	c.843G>C	c.(841-843)ATG>ATC	p.M281I	PCBP3_uc010gqb.2_Missense_Mutation_p.M281I|PCBP3_uc002zhp.1_Intron|PCBP3_uc002zhs.1_Missense_Mutation_p.M255I|PCBP3_uc002zhr.1_Missense_Mutation_p.M280I|PCBP3_uc002zht.1_Missense_Mutation_p.M271I	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	281					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		aaaatctgatgggccagtcat	0.279000													17	38					0	0	0	0
DIP2A	23181	broad.mit.edu	37	21	47969758	47969758	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr21:47969758C>T	uc002zjo.2	+	22	2780	c.2597C>T	c.(2596-2598)TCG>TTG	p.S866L	DIP2A_uc011afy.1_Missense_Mutation_p.S802L|DIP2A_uc011afz.1_Missense_Mutation_p.S862L|DIP2A_uc002zjn.2_Missense_Mutation_p.S866L	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	866					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CCGGATGCCTCGGAGGAGGAC	0.642000													37	118					0	0	0	0
SEC14L2	23541	broad.mit.edu	37	22	30812008	30812008	+	Silent	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr22:30812008C>T	uc003ahr.2	+	10	1016	c.843C>T	c.(841-843)AGC>AGT	p.S281S	SEC14L2_uc003ahq.2_Silent_p.S281S|SEC14L2_uc011akx.1_Silent_p.S227S|SEC14L2_uc003ahs.2_Silent_p.S207S|SEC14L2_uc011aky.1_Silent_p.S198S|SEC14L2_uc003aht.2_RNA|SEC14L2_uc003ahu.3_Silent_p.S105S|SEC14L2_uc010gvv.2_RNA|SEC14L2_uc010gvw.1_Intron|MTP18_uc010gvx.1_Intron|MTP18_uc003ahv.1_Silent_p.S105S|MTP18_uc010gvy.1_Intron	NM_012429	NP_036561	O76054	S14L2_HUMAN	SEC14-like 2 isoform 1	281	GOLD.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	phospholipid binding|transporter activity|vitamin E binding				0					Vitamin E(DB00163)	ATGAACACAGCGTGCAGATTT	0.557000													30	110					0	0	0	0
CACNG2	10369	broad.mit.edu	37	22	36960638	36960638	+	Silent	SNP	C	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr22:36960638C>A	uc003aps.1	-	4	1014	c.732G>T	c.(730-732)ACG>ACT	p.T244T		NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2	244					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0						GTGAGGGCTCCGTGGAGCGCG	0.697000													35	101					9.84934e-19	1.07712e-18	1	0
TADA3	10474	broad.mit.edu	37	3	9828794	9828794	+	Splice_Site	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:9828794C>T	uc003bsx.1	-	6	1255	c.707_splice	c.e6-1	p.D236_splice	TADA3_uc010hcn.1_Splice_Site_p.D236_splice|TADA3_uc003bsy.2_Splice_Site_p.D236_splice|TADA3_uc003bsw.1_Splice_Site_p.D65_splice	NM_006354	NP_006345	O75528	TADA3_HUMAN	transcriptional adaptor 3 isoform a						estrogen receptor signaling pathway|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	ligand-dependent nuclear receptor binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity				0						GCATCCACATCTAAGCGGGCA	0.597000											OREG0015382	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	64	212					0	0	0	0
SATB1	6304	broad.mit.edu	37	3	18393545	18393545	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:18393545G>A	uc003cbh.2	-	10	3453	c.1718C>T	c.(1717-1719)GCG>GTG	p.A573V	SATB1_uc003cbi.2_Missense_Mutation_p.A573V|SATB1_uc003cbj.2_Missense_Mutation_p.A573V	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	573					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4						GTGATGCACCGCGTTGCTCTC	0.498000													37	112					0	0	0	0
CACNA1D	776	broad.mit.edu	37	3	53844075	53844075	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:53844075G>A	uc003dgv.3	+	47	6105	c.5942G>A	c.(5941-5943)TGG>TAG	p.W1981*	CACNA1D_uc003dgu.3_Nonsense_Mutation_p.W2001*|CACNA1D_uc003dgy.3_Nonsense_Mutation_p.W1957*|CACNA1D_uc003dgw.3_Nonsense_Mutation_p.W1648*|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1981	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ACCCGGTCGTGGGCCACCCCT	0.612000													24	77					0	0	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64085080	64085080	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:64085080G>A	uc003dmf.2	-	8	2768	c.2182C>T	c.(2182-2184)CGC>TGC	p.R728C		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	728	Arg-rich.					cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CTCCGCTGGCGCATAAATTGG	0.617000													4	104					0	0	0	0
PDZRN3	23024	broad.mit.edu	37	3	73433477	73433477	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:73433477G>A	uc003dpl.1	-	10	2336	c.2240C>T	c.(2239-2241)CCG>CTG	p.P747L	PDZRN3_uc011bgh.1_Missense_Mutation_p.P404L|PDZRN3_uc010hoe.1_Missense_Mutation_p.P445L|PDZRN3_uc011bgf.1_Missense_Mutation_p.P464L|PDZRN3_uc011bgg.1_Missense_Mutation_p.P467L	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	747							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GGATTTCTCCGGGAGCTCGGT	0.612000													11	46					0	0	0	0
PHLDB2	90102	broad.mit.edu	37	3	111688638	111688638	+	Silent	SNP	A	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:111688638A>G	uc010hqa.2	+	16	3828	c.3417A>G	c.(3415-3417)GTA>GTG	p.V1139V	PHLDB2_uc003dyc.2_Silent_p.V1123V|PHLDB2_uc003dyd.2_Silent_p.V1096V|PHLDB2_uc003dyg.2_Silent_p.V1139V|PHLDB2_uc003dyh.2_Silent_p.V1096V|PHLDB2_uc003dyi.2_Silent_p.V630V|PHLDB2_uc003dyj.2_Silent_p.V194V	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	1139						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						GTTACCATGTATCAATCACAG	0.458000													27	87					0	0	0	0
TPRA1	131601	broad.mit.edu	37	3	127298632	127298632	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:127298632G>A	uc003ejl.2	-	2	500	c.209C>T	c.(208-210)GCG>GTG	p.A70V	TPRA1_uc003ejm.2_RNA|TPRA1_uc003ejo.2_Missense_Mutation_p.A70V|TPRA1_uc010hsk.2_Missense_Mutation_p.A70V|TPRA1_uc003ejn.2_Missense_Mutation_p.A70V	NM_016372	NP_057456	Q86W33	TPRA1_HUMAN	G protein-coupled receptor 175 isoform 1	70					aging|lipid metabolic process	integral to membrane	G-protein coupled receptor activity				0						GCGGATCTTCGCCCGAGCAGA	0.448000													10	34					0	0	0	0
ZBBX	79740	broad.mit.edu	37	3	167068267	167068267	+	Missense_Mutation	SNP	A	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:167068267A>T	uc003fep.2	-	9	792	c.469T>A	c.(469-471)TGC>AGC	p.C157S	ZBBX_uc011bpc.1_Missense_Mutation_p.C157S|ZBBX_uc003feq.2_Missense_Mutation_p.C128S	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	157	B box-type; atypical.					intracellular	zinc ion binding			ovary(2)	2						TTAGCAAAGCATCCTGAACAA	0.294000													6	370					0	0	0	0
NOP14	8602	broad.mit.edu	37	4	2948177	2948177	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:2948177C>G	uc003ggj.1	-	11	1669	c.1597G>C	c.(1597-1599)GAG>CAG	p.E533Q	C4orf10_uc003gge.1_Intron|C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Missense_Mutation_p.E279Q|NOP14_uc003ggk.3_Missense_Mutation_p.E533Q|NOP14_uc003ggl.2_Missense_Mutation_p.E533Q	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	533					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						CCTTTGGTCTCAATCATTTCT	0.488000													29	81					0	0	0	0
EPHA5	2044	broad.mit.edu	37	4	66230776	66230776	+	Missense_Mutation	SNP	T	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:66230776T>G	uc003hcy.2	-	12	2388	c.2195A>C	c.(2194-2196)GAT>GCT	p.D732A	EPHA5_uc003hcx.2_Missense_Mutation_p.D664A|EPHA5_uc003hcz.2_Missense_Mutation_p.D710A|EPHA5_uc011cah.1_Missense_Mutation_p.D733A|EPHA5_uc011cai.1_Missense_Mutation_p.D711A|EPHA5_uc003hda.2_Missense_Mutation_p.D733A	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	732	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GTTAGGATGATCAAACTGTCC	0.373000										TSP Lung(17;0.13)			46	177					0	0	0	0
HERC3	8916	broad.mit.edu	37	4	89583679	89583679	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:89583679C>G	uc003hrw.1	+	11	1410	c.1244C>G	c.(1243-1245)TCA>TGA	p.S415*	HERC3_uc011cdn.1_Nonsense_Mutation_p.S297*|HERC3_uc011cdo.1_Intron	NM_014606	NP_055421	Q15034	HERC3_HUMAN	hect domain and RLD 3	415					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			lung(2)|prostate(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		CAAAAACTCTCAGAACACAAC	0.348000													21	55					0	0	0	0
NDST3	9348	broad.mit.edu	37	4	119059259	119059259	+	Silent	SNP	G	T	T	rs142162150		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:119059259G>T	uc003ibx.2	+	5	1678	c.1275G>T	c.(1273-1275)TCG>TCT	p.S425S	NDST3_uc011cgf.1_Silent_p.S344S	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	425	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						CTCACCATTCGGGCGTCTACC	0.473000													32	119					6.03168e-27	6.69517e-27	1	0
SPRY1	10252	broad.mit.edu	37	4	124323279	124323279	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:124323279A>G	uc003ifa.2	+	2	721	c.533A>G	c.(532-534)AAG>AGG	p.K178R	SPRY1_uc003ifb.2_Missense_Mutation_p.K178R	NM_199327	NP_955359	O43609	SPY1_HUMAN	sprouty homolog 1, antagonist of FGF signaling	178					epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|lamellipodium|plasma membrane				skin(2)|ovary(1)	3						ACACAGCACAAGTTCATTTGT	0.527000													35	84					0	0	0	0
DDX60L	91351	broad.mit.edu	37	4	169341482	169341482	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:169341482G>A	uc003irq.3	-	18	2665	c.2444C>T	c.(2443-2445)ACG>ATG	p.T815M	DDX60L_uc003irr.1_Missense_Mutation_p.T815M|DDX60L_uc003irs.1_Missense_Mutation_p.T542M	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	815	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		GGCAGGCAACGTTTTAGTAAA	0.363000													5	31					0	0	0	0
IRF2	3660	broad.mit.edu	37	4	185311904	185311904	+	Splice_Site	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:185311904C>G	uc003iwf.3	-	8	895	c.695_splice	c.e8-1	p.E232_splice		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2						blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		GTTTCGCTTTCTGTTCACAGA	0.532000													27	72					0	0	0	0
NIPBL	25836	broad.mit.edu	37	5	36986387	36986387	+	Silent	SNP	A	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:36986387A>G	uc003jkl.3	+	10	3604	c.3105A>G	c.(3103-3105)CCA>CCG	p.P1035P	NIPBL_uc003jkk.3_Silent_p.P1035P|NIPBL_uc003jkm.1_Silent_p.P914P	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1035					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AGAATAAACCATCAAAGTCAA	0.274000													36	102					0	0	0	0
DAB2	1601	broad.mit.edu	37	5	39382739	39382739	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:39382739C>G	uc003jlx.2	-	10	1853	c.1322G>C	c.(1321-1323)AGA>ACA	p.R441T	DAB2_uc003jlw.2_Missense_Mutation_p.R420T	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	441					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			CCTTCTGCCTCTTCCTGGTTT	0.483000													45	149					0	0	0	0
F2RL1	2150	broad.mit.edu	37	5	76128686	76128686	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:76128686T>C	uc003keo.2	+	2	429	c.254T>C	c.(253-255)GTG>GCG	p.V85A		NM_005242	NP_005233	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	85	Helical; Name=1; (Potential).				blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			central_nervous_system(1)	1		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		TACACAATTGTGTTTGTGGTG	0.463000													59	189					0	0	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79743947	79743947	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:79743947C>G	uc003kgr.3	+	8	3129	c.2827C>G	c.(2827-2829)CAG>GAG	p.Q943E	ZFYVE16_uc003kgp.2_Missense_Mutation_p.Q943E|ZFYVE16_uc003kgq.3_Missense_Mutation_p.Q943E|ZFYVE16_uc003kgs.3_Missense_Mutation_p.Q943E|ZFYVE16_uc003kgt.3_Intron	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	943					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TCCTATTTCTCAGGTTCCATC	0.373000													27	95					0	0	0	0
RASGRF2	5924	broad.mit.edu	37	5	80422959	80422959	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:80422959C>A	uc003kha.1	+	17	2663	c.2663C>A	c.(2662-2664)GCA>GAA	p.A888E	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	888					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		GCCACAGCTGCAGCAGGACAT	0.498000													10	53					1.61879e-10	1.69515e-10	1	0
ERAP1	51752	broad.mit.edu	37	5	96136692	96136692	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:96136692G>A	uc003kmm.2	-	3	883	c.536C>T	c.(535-537)TCA>TTA	p.S179L	ERAP1_uc003kml.2_Missense_Mutation_p.S179L|ERAP1_uc010jbm.1_5'UTR|ERAP1_uc003kmn.2_Missense_Mutation_p.S179L	NM_001040458	NP_001035548	Q9NZ08	ERAP1_HUMAN	type 1 tumor necrosis factor receptor shedding	179	Lumenal (Potential).				angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		AAATTGTGTTGATGCTAGTAT	0.378000													23	95					0	0	0	0
BRD8	10902	broad.mit.edu	37	5	137486496	137486496	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:137486496C>G	uc003lcf.1	-	22	3113	c.3058G>C	c.(3058-3060)GAG>CAG	p.E1020Q	BRD8_uc003lcc.1_Intron	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	1020					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GAAGCCACCTCTGGCTTTCCA	0.463000													49	154					0	0	0	0
EGR1	1958	broad.mit.edu	37	5	137802445	137802445	+	Splice_Site	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:137802445G>C	uc003ldb.1	+	2	578	c.308_splice	c.e2-1	p.E103_splice	EGR1_uc011cyu.1_Splice_Site_p.E103_splice	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1						cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			TCTCCTGCCAGAGTCTTTTCC	0.592000													68	280					0	0	0	0
DNAJC18	202052	broad.mit.edu	37	5	138773229	138773229	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:138773229C>T	uc003len.2	-	2	64	c.59G>A	c.(58-60)AGA>AAA	p.R20K	DNAJC18_uc010jff.2_Missense_Mutation_p.R20K	NM_152686	NP_689899	Q9H819	DJC18_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 18	20					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)|kidney(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TTTGTTTCTTCTAACTGCGTC	0.478000													25	96					0	0	0	0
NRG2	9542	broad.mit.edu	37	5	139422206	139422206	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:139422206C>A	uc003lex.1	-	1	674	c.449G>T	c.(448-450)CGA>CTA	p.R150L	NRG2_uc003lev.1_Missense_Mutation_p.R150L|NRG2_uc003lew.1_Missense_Mutation_p.R150L|NRG2_uc003ley.1_Missense_Mutation_p.R150L	NM_004883	NP_004874	O14511	NRG2_HUMAN	neuregulin 2 isoform 1	150	Extracellular (Potential).				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			pancreas(2)|breast(2)|ovary(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGGCTCTCGGGTGCTGTT	0.697000													3	17					2.56e-06	2.63111e-06	1	0
PCDHB12	56124	broad.mit.edu	37	5	140590604	140590604	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:140590604G>A	uc003liz.2	+	1	2314	c.2125G>A	c.(2125-2127)GTG>ATG	p.V709M	PCDHB12_uc011dak.1_Missense_Mutation_p.V372M|PCDHB13_uc003lja.1_5'Flank	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	709	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCCTGTTCGTGGCGGTGCG	0.697000													44	199					0	0	0	0
FBXO38	81545	broad.mit.edu	37	5	147796565	147796565	+	Silent	SNP	T	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:147796565T>G	uc003lpf.1	+	12	1536	c.1416T>G	c.(1414-1416)GCT>GCG	p.A472A	FBXO38_uc003lpg.1_Silent_p.A472A|FBXO38_uc003lph.2_Silent_p.A472A	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	472						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGGTTGTGCTCGAGTTGGTC	0.373000													18	50					0	0	0	0
NIPAL4	348938	broad.mit.edu	37	5	156895764	156895764	+	Silent	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:156895764C>T	uc003lwx.3	+	4	671	c.555C>T	c.(553-555)TAC>TAT	p.Y185Y	ADAM19_uc003lww.1_Intron|NIPAL4_uc011ddq.1_Silent_p.Y166Y|NIPAL4_uc010jin.1_3'UTR	NM_001099287	NP_001092757	Q0D2K0	NIPA4_HUMAN	ichthyin protein	185	Helical; (Potential).					integral to membrane	receptor activity				0						TTGGAGCCTACGCATTTGCAC	0.507000													36	96					0	0	0	0
MGAT4B	11282	broad.mit.edu	37	5	179228838	179228838	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr5:179228838C>G	uc003mks.2	-	2	598	c.229G>C	c.(229-231)GAA>CAA	p.E77Q	MGAT4B_uc003mkp.2_5'Flank|MGAT4B_uc003mkq.2_5'UTR|MGAT4B_uc003mkr.2_Missense_Mutation_p.E92Q	NM_014275	NP_055090	Q9UQ53	MGT4B_HUMAN	alpha-1,3-mannosyl-glycoprotein	77	Potential.|Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding				0	all_cancers(89;0.000201)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0525)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCTGCCTTTCTGACACGGCC	0.672000											OREG0017110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	35					0	0	0	0
PRL	5617	broad.mit.edu	37	6	22294711	22294711	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:22294711C>T	uc003ndp.2	-	2	650	c.131G>A	c.(130-132)CGA>CAA	p.R44Q	PRL_uc003ndo.2_Missense_Mutation_p.R45Q|PRL_uc003ndq.2_Missense_Mutation_p.R44Q|PRL_uc003ndr.1_RNA	NM_000948	NP_000939	P01236	PRL_HUMAN	prolactin precursor	44					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding				0	Ovarian(93;0.163)					AAACAGGTCTCGAAGGGTCAC	0.602000													12	33					0	0	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26156774	26156774	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:26156774G>A	uc003ngq.2	+	1	216	c.156G>A	c.(154-156)AAG>AAA	p.K52K	HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312	P10412	H14_HUMAN	histone cluster 1, H1e	52	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2						CCGCCTCCAAGGAGCGCAGCG	0.607000													7	56					0	0	0	0
DST	667	broad.mit.edu	37	6	56443679	56443679	+	Silent	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:56443679C>T	uc003pdf.2	-	44	6631	c.6603G>A	c.(6601-6603)ACG>ACA	p.T2201T	DST_uc003pcz.3_Silent_p.T2023T|DST_uc011dxj.1_Silent_p.T2052T|DST_uc011dxk.1_Silent_p.T2063T|DST_uc003pcy.3_Silent_p.T1697T|DST_uc010kaa.1_RNA	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	4109	Spectrin 3.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GCACTTCAGCCGTTTTCTTCA	0.413000													7	22					0	0	0	0
BAI3	577	broad.mit.edu	37	6	70098604	70098604	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:70098604G>A	uc003pev.3	+	32	4838	c.4390G>A	c.(4390-4392)GCA>ACA	p.A1464T	BAI3_uc010kak.2_Missense_Mutation_p.A1464T|BAI3_uc011dxx.1_Missense_Mutation_p.A670T	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1464	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GGAAAACCCCGCACCAAACAA	0.448000													9	31					0	0	0	0
EEF1A1	1915	broad.mit.edu	37	6	74228304	74228304	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:74228304C>G	uc003phi.2	-	5	839	c.802G>C	c.(802-804)GAG>CAG	p.E268Q	EEF1A1_uc003phd.2_5'UTR|EEF1A1_uc003phe.2_Missense_Mutation_p.E258Q|EEF1A1_uc003phf.2_Missense_Mutation_p.E268Q|EEF1A1_uc003phg.2_Missense_Mutation_p.E268Q|EEF1A1_uc003phh.2_Missense_Mutation_p.E114Q|EEF1A1_uc003phj.2_Missense_Mutation_p.E268Q|EEF1A1_uc003phk.2_Missense_Mutation_p.E268Q|EEF1A1_uc003phl.2_Intron|EEF1A1_uc003phm.1_Intron	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	268						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						ACACCAGTCTCCACTCGGCCA	0.418000											OREG0003895	type=REGULATORY REGION|Gene=D16891|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	17	77					0	0	0	0
ZNF292	23036	broad.mit.edu	37	6	87964636	87964636	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:87964636G>A	uc003plm.3	+	8	1330	c.1289G>A	c.(1288-1290)TGT>TAT	p.C430Y		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	430					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TCTTTACGCTGTGAGCTGTTA	0.388000													10	46					0	0	0	0
THEMIS	387357	broad.mit.edu	37	6	128150927	128150927	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:128150927G>T	uc003qbi.2	-	4	722	c.403C>A	c.(403-405)CAA>AAA	p.Q135K	THEMIS_uc010kfa.2_Missense_Mutation_p.Q38K|THEMIS_uc011ebt.1_Missense_Mutation_p.Q135K|THEMIS_uc010kfb.2_Missense_Mutation_p.Q100K	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	135	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						AGCATGATTTGCTCACCCTGC	0.403000													69	196					3.31162e-33	3.69437e-33	1	0
SHPRH	257218	broad.mit.edu	37	6	146271470	146271470	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:146271470C>G	uc003qlf.2	-	4	1311	c.912G>C	c.(910-912)TTG>TTC	p.L304F	SHPRH_uc003qld.2_Missense_Mutation_p.L304F|SHPRH_uc003qle.2_Missense_Mutation_p.L304F|SHPRH_uc003qlg.1_5'UTR|SHPRH_uc003qlj.1_Missense_Mutation_p.L193F|SHPRH_uc003qlk.1_Missense_Mutation_p.L304F	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	304					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		GGTAGGGTCTCAACACAGGGA	0.433000													3	218					0	0	0	0
MAD1L1	8379	broad.mit.edu	37	7	2265120	2265120	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:2265120C>T	uc003slh.1	-	4	482	c.216G>A	c.(214-216)ATG>ATA	p.M72I	MAD1L1_uc003slf.1_Missense_Mutation_p.M72I|MAD1L1_uc003slg.1_Missense_Mutation_p.M72I|MAD1L1_uc010ksh.1_Missense_Mutation_p.M72I|MAD1L1_uc003sli.1_Intron|MAD1L1_uc010ksi.1_Intron|MAD1L1_uc010ksj.2_Missense_Mutation_p.M72I	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	72	Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		GCTCCATCTGCATTTTCTCCC	0.587000													38	93					0	0	0	0
SP4	6671	broad.mit.edu	37	7	21469033	21469033	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:21469033C>T	uc003sva.2	+	3	431	c.250C>T	c.(250-252)CAA>TAA	p.Q84*	SP4_uc003svb.2_5'UTR	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	84					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						GGTGCAACTTCAAAATCAACC	0.433000													29	69					0	0	0	0
STK31	56164	broad.mit.edu	37	7	23825188	23825188	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:23825188G>A	uc003sws.3	+	18	2307	c.2240G>A	c.(2239-2241)CGT>CAT	p.R747H	STK31_uc003swt.3_Missense_Mutation_p.R724H|STK31_uc011jze.1_Missense_Mutation_p.R747H|STK31_uc010kuq.2_Missense_Mutation_p.R724H|STK31_uc003swv.1_5'Flank	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	747	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						CCTTTGGTACGTTCTGAGGTT	0.438000													61	192					0	0	0	0
GCK	2645	broad.mit.edu	37	7	44185251	44185251	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:44185251G>A	uc003tkl.2	-	9	1568	c.1098C>T	c.(1096-1098)ATC>ATT	p.I366I	GCK_uc003tkh.1_Silent_p.I39I|GCK_uc003tki.1_Silent_p.I44I|GCK_uc003tkj.1_Silent_p.I365I|GCK_uc003tkk.1_Silent_p.I367I	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	366					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						CGCGGCGCACGATGTCGCAGT	0.706000													7	23					0	0	0	0
PURB	5814	broad.mit.edu	37	7	44924866	44924866	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:44924866C>A	uc003tme.2	-	1	95	c.82G>T	c.(82-84)GAG>TAG	p.E28*		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	28	By similarity.				regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						GTCTCTTGCTCGCCGCCGCCG	0.443000													4	12					2.0095e-06	2.07492e-06	1	0
MAGI2	9863	broad.mit.edu	37	7	78131057	78131057	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:78131057G>A	uc003ugx.2	-	5	1056	c.802C>T	c.(802-804)CCC>TCC	p.P268S	MAGI2_uc003ugy.2_Missense_Mutation_p.P268S|MAGI2_uc011kgr.1_Missense_Mutation_p.P100S|MAGI2_uc011kgs.1_Missense_Mutation_p.P105S	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	268	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GGCTGGGAGGGCATCTCCCCT	0.498000													4	94					0	0	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87459257	87459257	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:87459257G>C	uc003ujb.2	+	12	1745	c.1334G>C	c.(1333-1335)AGT>ACT	p.S445T	RUNDC3B_uc011khe.1_Missense_Mutation_p.S428T|RUNDC3B_uc003ujc.2_Missense_Mutation_p.S379T|RUNDC3B_uc003ujd.2_Missense_Mutation_p.S301T	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	445										skin(1)	1	Esophageal squamous(14;0.00164)					TCAGTGGCAAGTTACAAGTCT	0.378000													55	163					0	0	0	0
SPDYE3	441272	broad.mit.edu	37	7	99917323	99917323	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:99917323G>A	uc003uug.1	+	4	591	c.351G>A	c.(349-351)CCG>CCA	p.P117P	uc011kjm.1_5'Flank	NM_001004351	NP_001004351	A6NKU9	SPDE3_HUMAN	speedy homolog E3	494											0						CCATGAACCCGAGGGCCAGGA	0.547000													37	118					0	0	0	0
LAMB4	22798	broad.mit.edu	37	7	107752256	107752256	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:107752256C>A	uc010ljo.1	-	4	412	c.328G>T	c.(328-330)GGT>TGT	p.G110C	LAMB4_uc003vey.2_Missense_Mutation_p.G110C	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	110	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TAAATCATACCATTTTCAGAT	0.338000													40	89					6.2361e-21	6.85354e-21	1	0
CADPS2	93664	broad.mit.edu	37	7	122033249	122033249	+	Splice_Site	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:122033249C>T	uc010lkp.2	-	21	3171	c.3008_splice	c.e21+1	p.T1003_splice	CADPS2_uc011knx.1_Splice_Site_p.T378_splice|CADPS2_uc003vkg.3_Intron|CADPS2_uc010lkq.2_Intron	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2						exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						GGAATACACACGTGGACTCAT	0.458000													8	27					0	0	0	0
TAS2R38	5726	broad.mit.edu	37	7	141672668	141672668	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:141672668G>A	uc003vwx.1	-	1	906	c.822C>T	c.(820-822)CGC>CGT	p.R274R		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	274	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					CTATTTTGTCGCGCCACAGAA	0.502000													23	67					0	0	0	0
RP1L1	94137	broad.mit.edu	37	8	10480315	10480315	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:10480315C>T	uc003wtc.2	-	2	626	c.397G>A	c.(397-399)GAA>AAA	p.E133K		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	133					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CGCTGGCCTTCGACATCCCGC	0.607000													36	57					0	0	0	0
FDFT1	2222	broad.mit.edu	37	8	11679320	11679320	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:11679320G>A	uc003wui.2	+	4	595	c.443G>A	c.(442-444)CGG>CAG	p.R148Q	FDFT1_uc003wuh.2_Missense_Mutation_p.R84Q|FDFT1_uc010lsa.1_Missense_Mutation_p.R63Q|FDFT1_uc011kxe.1_Missense_Mutation_p.R84Q|FDFT1_uc011kxf.1_Intron|FDFT1_uc011kxg.1_Intron|FDFT1_uc003wuj.2_Missense_Mutation_p.R141Q|FDFT1_uc010lsb.2_Missense_Mutation_p.R84Q|FDFT1_uc011kxh.1_Missense_Mutation_p.R84Q|FDFT1_uc011kxi.1_RNA|FDFT1_uc011kxj.1_Missense_Mutation_p.R84Q|FDFT1_uc003wuk.2_Missense_Mutation_p.R207Q|FDFT1_uc011kxk.1_Missense_Mutation_p.R63Q	NM_004462	NP_004453	P37268	FDFT_HUMAN	squalene synthase	148					cholesterol biosynthetic process|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	farnesyl-diphosphate farnesyltransferase activity|oxidoreductase activity|protein binding|squalene synthase activity				0	all_epithelial(15;0.234)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.18)		GACATTTGCCGGAGAATGGGC	0.423000													4	200					0	0	0	0
DLC1	10395	broad.mit.edu	37	8	12957760	12957760	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:12957760C>T	uc003wwm.2	-	9	2530	c.2086G>A	c.(2086-2088)GGG>AGG	p.G696R	DLC1_uc003wwk.1_Missense_Mutation_p.G259R|DLC1_uc003wwl.1_Missense_Mutation_p.G293R|DLC1_uc011kxx.1_Missense_Mutation_p.G185R	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	696					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						AAGATGGGCCCGCTGATGATC	0.572000													92	110					0	0	0	0
TRIM35	23087	broad.mit.edu	37	8	27145246	27145246	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:27145246C>T	uc003xfl.1	-	6	1385	c.1303G>A	c.(1303-1305)GAG>AAG	p.E435K	TRIM35_uc010lup.1_3'UTR	NM_171982	NP_741983	Q9UPQ4	TRI35_HUMAN	tripartite motif-containing 35 isoform 2	435	B30.2/SPRY.				apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding				0		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		TCGCCCTCCTCACACTCCAGC	0.682000													5	10					0	0	0	0
RSPO2	340419	broad.mit.edu	37	8	108913336	108913336	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:108913336G>T	uc003yms.2	-	6	1357	c.699C>A	c.(697-699)AGC>AGA	p.S233R	RSPO2_uc003ymq.2_Missense_Mutation_p.S166R|RSPO2_uc003ymr.2_Missense_Mutation_p.S169R	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	233					Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			CTAGGAAGACGCTGTGTTGCT	0.353000													22	147					5.35356e-11	5.65948e-11	1	0
TNFRSF11B	4982	broad.mit.edu	37	8	119938851	119938851	+	Silent	SNP	G	A	A	rs150457771		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:119938851G>A	uc003yon.3	-	4	1022	c.699C>T	c.(697-699)AAC>AAT	p.N233N	TNFRSF11B_uc010mdc.1_RNA	NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	233	Death 1.				apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			CACTCTCTGCGTTTACTTTGG	0.443000													52	201					0	0	0	0
KCNQ3	3786	broad.mit.edu	37	8	133144493	133144493	+	Silent	SNP	G	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:133144493G>C	uc003ytj.2	-	14	2043	c.1818C>G	c.(1816-1818)GCC>GCG	p.A606A	KCNQ3_uc010mdt.2_Silent_p.A594A	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	606					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TGGATGGTCTGGCTACATATG	0.403000													57	71					0	0	0	0
TG	7038	broad.mit.edu	37	8	133978843	133978843	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:133978843C>A	uc003ytw.2	+	30	5628	c.5587C>A	c.(5587-5589)CAG>AAG	p.Q1863K	TG_uc010mdw.2_Missense_Mutation_p.Q622K|TG_uc011ljb.1_Missense_Mutation_p.Q232K|TG_uc011ljc.1_Missense_Mutation_p.Q17K|TG_uc010mdx.1_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1863	Type IIIB.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGACCTCAACCAGGTCATTGT	0.453000													35	155					2.52637e-11	2.68352e-11	1	0
CYP11B1	1584	broad.mit.edu	37	8	143956467	143956467	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:143956467C>T	uc003yxi.2	-	8	1311	c.1304G>A	c.(1303-1305)GGC>GAC	p.G435D	CYP11B1_uc010mex.2_Missense_Mutation_p.G134D|CYP11B1_uc003yxh.2_Intron|CYP11B1_uc003yxj.2_Intron|CYP11B1_uc010mey.2_Missense_Mutation_p.G506D	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	435					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GAAGTTCCTGCCGGAGCCCCT	0.637000									Familial_Hyperaldosteronism_type_I				59	110					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144991583	144991583	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr8:144991583C>T	uc003zaf.1	-	32	12987	c.12817G>A	c.(12817-12819)GTG>ATG	p.V4273M	PLEC_uc003zab.1_Missense_Mutation_p.V4136M|PLEC_uc003zac.1_Missense_Mutation_p.V4140M|PLEC_uc003zad.2_Missense_Mutation_p.V4136M|PLEC_uc003zae.1_Missense_Mutation_p.V4104M|PLEC_uc003zag.1_Missense_Mutation_p.V4114M|PLEC_uc003zah.2_Missense_Mutation_p.V4122M|PLEC_uc003zaj.2_Missense_Mutation_p.V4163M	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4273	Binding to intermediate filaments (By similarity).|Globular 2.|Plectin 27.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGCTTGCGCACGGAGGACTTG	0.617000													25	106					0	0	0	0
SMARCA2	6595	broad.mit.edu	37	9	2039806	2039806	+	Silent	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:2039806G>A	uc003zhc.2	+	4	795	c.696G>A	c.(694-696)CAG>CAA	p.Q232Q	SMARCA2_uc003zhd.2_Silent_p.Q232Q|SMARCA2_uc010mha.2_Silent_p.Q223Q	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	232	Poly-Gln.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		agcagcagcagcagcagcagc	0.234000													2	1					0	0	0	0
KIAA1432	57589	broad.mit.edu	37	9	5763752	5763752	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:5763752G>A	uc003zji.2	+	18	2581	c.2488G>A	c.(2488-2490)GAA>AAA	p.E830K	KIAA1432_uc003zjh.2_Missense_Mutation_p.E830K|KIAA1432_uc003zjl.3_Missense_Mutation_p.E793K|KIAA1432_uc003zjj.1_Missense_Mutation_p.E372K	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	909						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CAGGAAGACCGAATATGCCCT	0.502000													67	259					0	0	0	0
IFNA16	3449	broad.mit.edu	37	9	21216761	21216761	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:21216761G>T	uc003zor.1	-	1	550	c.544C>A	c.(544-546)CAA>AAA	p.Q182K	IFNA14_uc003zoo.1_Intron	NM_002173	NP_002164	P05015	IFN16_HUMAN	interferon, alpha 16 precursor	182					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			skin(1)	1				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		AATCCTTTTTGCAAGTTTGTT	0.373000													190	422					8.32648e-103	9.47938e-103	1	0
DMRTA1	63951	broad.mit.edu	37	9	22451198	22451198	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:22451198C>G	uc003zpp.1	+	2	1028	c.803C>G	c.(802-804)TCA>TGA	p.S268*		NM_022160	NP_071443	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	268					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|skin(1)	2		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		TCATCTATTTCAGAATACTCC	0.448000													44	77					0	0	0	0
DMRTA1	63951	broad.mit.edu	37	9	22451226	22451226	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:22451226C>G	uc003zpp.1	+	2	1056	c.831C>G	c.(829-831)ATC>ATG	p.I277M		NM_022160	NP_071443	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	277					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|skin(1)	2		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		CTGATAGTATCCTGTCTCCTC	0.438000													39	66					0	0	0	0
C9orf128	392307	broad.mit.edu	37	9	35825248	35825248	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:35825248C>T	uc010mlc.2	-	3	1006	c.721G>A	c.(721-723)GCC>ACC	p.A241T	C9orf128_uc003zyj.2_RNA|C9orf128_uc011lpg.1_Missense_Mutation_p.A241T	NM_001012446	NP_001012448	A6H8Z2	CI128_HUMAN	hypothetical protein LOC392307	241											0	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			GCATTCAGGGCTGCATCCTTC	0.532000													49	68					0	0	0	0
COL5A1	1289	broad.mit.edu	37	9	137591821	137591821	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:137591821T>C	uc004cfe.2	+	3	726	c.344T>C	c.(343-345)TTC>TCC	p.F115S		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	115	TSP N-terminal.|Laminin G-like.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGCCAGGCCTTCCTGGTCTCC	0.587000													30	93					0	0	0	0
KIAA1984	84960	broad.mit.edu	37	9	139701274	139701274	+	Silent	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:139701274C>T	uc004cjf.2	+	12	1392	c.1344C>T	c.(1342-1344)CTC>CTT	p.L448L	C9orf86_uc004cjm.2_5'Flank|C9orf86_uc004cjh.2_5'Flank|C9orf86_uc004cjj.1_5'Flank|C9orf86_uc004cjk.1_5'Flank|C9orf86_uc004cji.1_5'Flank|C9orf86_uc010nbr.1_5'Flank|LOC100131193_uc004cjg.1_Intron	NM_001039374	NP_001034463	Q5T5S1	K1984_HUMAN	hypothetical protein LOC84960	448										ovary(1)	1	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.33e-06)|Epithelial(140;0.000124)		AGGGGAAGCTCACGTACCTGG	0.617000													11	50					0	0	0	0
BCOR	54880	broad.mit.edu	37	X	39930340	39930340	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chrX:39930340C>T	uc004den.3	-	6	3416	c.3124G>A	c.(3124-3126)GAG>AAG	p.E1042K	BCOR_uc004dep.3_Missense_Mutation_p.E1042K|BCOR_uc004deo.3_Missense_Mutation_p.E1024K|BCOR_uc004dem.3_Missense_Mutation_p.E1042K	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1042					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TTGCACATCTCGGAGTCTTTG	0.488000													34	28					0	0	0	0
KLHL13	90293	broad.mit.edu	37	X	117033238	117033238	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chrX:117033238C>A	uc004eql.2	-	7	1663	c.1601G>T	c.(1600-1602)GGA>GTA	p.G534V	KLHL13_uc004eqk.2_Missense_Mutation_p.G483V|KLHL13_uc011mtn.1_Missense_Mutation_p.G374V|KLHL13_uc011mto.1_Missense_Mutation_p.G528V|KLHL13_uc011mtp.1_Missense_Mutation_p.G536V|KLHL13_uc004eqm.2_Missense_Mutation_p.G483V|KLHL13_uc011mtq.1_Missense_Mutation_p.G518V	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	534	Kelch 4.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						GAGCCTTTCTCCCACTGTACA	0.458000													175	184					1.12187e-70	1.27069e-70	1	0
Unknown	0	broad.mit.edu	37	10	134957000	134957000	+	IGR	DEL	T	-	-	rs35462802		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr10:134957000delT								GPR123 (11822 upstream) : KNDC1 (16971 downstream)																							ACACCTCGTCTTTTTTTTTTT	0.478													---	---	---							
Unknown	0	broad.mit.edu	37	11	55568573	55568574	+	IGR	DEL	GT	-	-	rs141163335		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr11:55568573_55568574delGT								OR5D14 (4598 upstream) : OR5L1 (10369 downstream)																							AAAACTTCCAgtgtgtgtgtgt	0.188													---	---	---							
SPSB2	84727	broad.mit.edu	37	12	6980443	6980444	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:6980443_6980444delCA	uc001qrl.2	-	3	860_861	c.704_705delTG	c.(703-705)GTGfs	p.V235fs	SPSB2_uc001qrm.2_Frame_Shift_Del_p.V235fs|LRRC23_uc001qrn.1_5'Flank	NM_001146316	NP_001139788	Q99619	SPSB2_HUMAN	splA/ryanodine receptor domain and SOCS box	235	SOCS box.				intracellular signal transduction	cytoplasm	protein binding			kidney(1)	1						GGTTGTGGCGCACACACAGGCG	0.624													---	---	---							
Unknown	0	broad.mit.edu	37	12	28208612	28208613	+	IGR	INS	-	TACACACACACC	TACACACACACC	rs143122047	by1000genomes	TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr12:28208612_28208613insTACACACACACC								PTHLH (83696 upstream) : CCDC91 (123597 downstream)																							ATGTGTGTGTGTacacacacac	0.228													---	---	---							
EXOSC8	11340	broad.mit.edu	37	13	37578686	37578686	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr13:37578686delA	uc001uwa.2	+	5	491	c.226delA	c.(226-228)AAAfs	p.K76fs	EXOSC8_uc001uvz.2_RNA|EXOSC8_uc001uwb.2_Frame_Shift_Del_p.K76fs|EXOSC8_uc001uwc.2_RNA	NM_181503	NP_852480	Q96B26	EXOS8_HUMAN	exosome component 8	76					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	AU-rich element binding|identical protein binding			pancreas(1)	1		Lung NSC(96;6.57e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.67e-07)|Epithelial(112;1.31e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00699)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0411)		TGCCCCTGATAAAGGATACGT	0.289													---	---	---							
Unknown	0	broad.mit.edu	37	13	47327220	47327221	+	IGR	DEL	CA	-	-	rs35079195		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr13:47327220_47327221delCA								LRCH1 (47 upstream) : ESD (18171 downstream)																							TGACCCCGGTcacacacacaca	0.248													---	---	---							
Unknown	0	broad.mit.edu	37	15	78202278	78202278	+	IGR	DEL	C	-	-	rs71145877		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr15:78202278delC								LINGO1 (213803 upstream) : LOC645752 (4281 downstream)																							TTGACAGTGGCTCCCCCAGCC	0.577													---	---	---							
Unknown	0	broad.mit.edu	37	16	31345826	31345829	+	IGR	DEL	CCTT	-	-	rs12932165		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr16:31345826_31345829delCCTT								ITGAM (1615 upstream) : ITGAX (20680 downstream)																							tctttctttcccttccttccttcc	0.005													---	---	---							
Unknown	0	broad.mit.edu	37	17	75921951	75921952	+	IGR	INS	-	AAGG	AAGG	rs28641037		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr17:75921951_75921952insAAGG								FLJ45079 (41782 upstream) : TNRC6C (78366 downstream)																							aaaaagaaagaaaggaaggaag	0.144													---	---	---							
Unknown	0	broad.mit.edu	37	2	64505161	64505161	+	IGR	DEL	C	-	-			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:64505161delC								PELI1 (133556 upstream) : HSPC159 (176166 downstream)																							ttccctccctccccccctttt	0.134													---	---	---							
SPEG	10290	broad.mit.edu	37	2	220300061	220300061	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr2:220300061delC	uc010fwg.2	+	1	362	c.362delC	c.(361-363)GCGfs	p.A121fs	SPEG_uc002vlm.2_5'Flank	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	121	Ig-like 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCCTGCGAGGCGGTGCTCACA	0.741													---	---	---							
Unknown	0	broad.mit.edu	37	20	2218573	2218573	+	IGR	DEL	T	-	-			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr20:2218573delT								STK35 (89377 upstream) : TGM3 (58040 downstream)																							tctttctttctttctttcttt	0.015													---	---	---							
PFKFB4	5210	broad.mit.edu	37	3	48575989	48575993	+	Frame_Shift_Del	DEL	TGAAG	-	-			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:48575989_48575993delTGAAG	uc003ctv.2	-	7	587_591	c.570_574delCTTCA	c.(568-576)GACTTCATGfs	p.D190fs	PFKFB4_uc003ctw.2_Translation_Start_Site|PFKFB4_uc010hkc.2_Frame_Shift_Del_p.D190fs|PFKFB4_uc003ctx.2_Frame_Shift_Del_p.D147fs|PFKFB4_uc010hkb.2_Frame_Shift_Del_p.D190fs|PFKFB4_uc011bbm.1_Frame_Shift_Del_p.D179fs|PFKFB4_uc011bbn.1_RNA	NM_004567	NP_004558	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,	190_192	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		ATGCGCCTCATGAAGTCCTCCGTAG	0.576													---	---	---							
Unknown	0	broad.mit.edu	37	3	98371791	98371794	+	IGR	DEL	AGAA	-	-	rs9882856		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:98371791_98371794delAGAA								CPOX (59350 upstream) : ST3GAL6 (79358 downstream)																							agagtgagagagaaagaaagaaag	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	3	194672739	194672740	+	IGR	INS	-	AGGAAGGA	AGGAAGGA			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr3:194672739_194672740insAGGAAGGA								FAM43A (262975 upstream) : C3orf21 (116275 downstream)																							gggagggagtgaggaaggaagg	0.010													---	---	---							
ARAP2	116984	broad.mit.edu	37	4	36148978	36148979	+	Frame_Shift_Ins	INS	-	T	T	rs148742461	by1000genomes	TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:36148978_36148979insT	uc003gsq.1	-	19	3540_3541	c.3202_3203insA	c.(3202-3204)ATCfs	p.I1068fs		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1068	PH 4.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CATTGTGCTGATTGCTGAAGGG	0.332													---	---	---							
Unknown	0	broad.mit.edu	37	4	125391768	125391771	+	IGR	DEL	TCTT	-	-			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:125391768_125391771delTCTT								LOC285419 (540250 upstream) : ANKRD50 (193697 downstream)																							tctccctttctctttctttctttc	0.049													---	---	---							
Unknown	0	broad.mit.edu	37	4	138754854	138754855	+	IGR	INS	-	A	A			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr4:138754854_138754855insA								PCDH18 (301206 upstream) : SLC7A11 (330393 downstream)																							gaaaggaaaggaaagagggagg	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	6	9100701	9100705	+	IGR	DEL	CCCTC	-	-	rs35489941		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:9100701_9100705delCCCTC								HULC (446624 upstream) : None (None downstream)																							cttccttcctccctctccttcctct	0.005													---	---	---							
MLLT4	4301	broad.mit.edu	37	6	168317900	168317900	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr6:168317900delT	uc003qwd.2	+	19	2815	c.2673delT	c.(2671-2673)CCTfs	p.P891fs	MLLT4_uc003qwb.1_Frame_Shift_Del_p.P876fs|MLLT4_uc003qwc.1_Frame_Shift_Del_p.P892fs|MLLT4_uc003qwg.1_Frame_Shift_Del_p.P201fs	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	892	Dilute.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CTGATGAGCCTTTTATCCCAA	0.398			T	MLL	AL								---	---	---							
Unknown	0	broad.mit.edu	37	7	64975077	64975078	+	IGR	INS	-	AGAC	AGAC			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr7:64975077_64975078insAGAC								ZNF92 (109080 upstream) : INTS4L2 (137699 downstream)																							AGTGCACCCGAAAACAAAGATG	0.455													---	---	---							
Unknown	0	broad.mit.edu	37	9	67791249	67791250	+	5'Flank	DEL	AC	-	-	rs74992488		TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chr9:67791249_67791250delAC	uc004aes.1	+											Homo sapiens cDNA FLJ36039 fis, clone TESTI2017311.																		agaatgggagacacacacacac	0.064													---	---	---							
CNKSR2	22866	broad.mit.edu	37	X	21627677	21627678	+	In_Frame_Ins	INS	-	GAG	GAG			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chrX:21627677_21627678insGAG	uc004czx.1	+	20	2670_2671	c.2634_2635insGAG	c.(2632-2637)insGAG	p.886_887insE	CNKSR2_uc004czw.2_In_Frame_Ins_p.886_887insE|CNKSR2_uc011mjn.1_In_Frame_Ins_p.837_838insE|CNKSR2_uc011mjo.1_In_Frame_Ins_p.856_857insE|CNKSR2_uc004czy.2_In_Frame_Ins_p.478_479insE	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	886_887	Potential.|Poly-Glu.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						aggtggaggaagaggaggagga	0.376													---	---	---							
CYorf15B	84663	broad.mit.edu	37	Y	21758039	21758039	+	5'Flank	DEL	A	-	-			TCGA-CN-4734-01A-01D-1434-08	TCGA-CN-4734-10A-01D-1434-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd54bbfa-62a2-4d8b-88fb-b74b91e1b958	0a364971-3490-42ca-bd60-a031d081612d	g.chrY:21758039delA	uc011nay.1	+							NM_032576	NP_115965	Q9BZA4	CY15B_HUMAN	lipopolysaccaride-specific response 5-like												0						TACTTCTTGGAAAAAAAAAAA	0.378													---	---	---							
