Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
LIN28A	79727	broad.mit.edu	37	1	26751932	26751932	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:26751932C>T	uc001bmj.2	+	3	481	c.367C>T	c.(367-369)CGG>TGG	p.R123W	LIN28A_uc001bmi.1_RNA	NM_024674	NP_078950	Q9H9Z2	LN28A_HUMAN	lin-28 homolog	123					miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing|stem cell maintenance	cytoplasmic mRNA processing body|nucleolus|stress granule	DNA binding|zinc ion binding			central_nervous_system(1)	1						GAGTGAGAGGCGGCCAAAAGG	0.522000													9	108					0	0	0	0
GSTM2	2946	broad.mit.edu	37	1	110211933	110211933	+	Missense_Mutation	SNP	A	G	G	rs2227960	byFrequency	TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:110211933A>G	uc001dyi.2	+	4	513	c.199A>G	c.(199-201)ACT>GCT	p.T67A	GSTM2_uc001dyj.2_Missense_Mutation_p.T67A|GSTM2_uc010ovt.1_Missense_Mutation_p.T67A|GSTM2_uc009wfk.2_RNA	NM_000848	NP_000839	P28161	GSTM2_HUMAN	glutathione S-transferase mu 2 isoform 1	67	GST N-terminal.				glutathione metabolic process|xenobiotic catabolic process	cytoplasm	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	GATTGATGGGACTCACAAGAT	0.572000													23	221					0	0	0	0
C1orf103	55791	broad.mit.edu	37	1	111494604	111494604	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:111494604G>A	uc001eaa.2	-	2	1158	c.902C>T	c.(901-903)ACG>ATG	p.T301M	C1orf103_uc001dzz.2_Intron|C1orf103_uc001eab.2_Intron|C1orf103_uc001eac.1_Intron	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		AAGAGATGGCGTAAAAGGCTG	0.343000													6	66					0	0	0	0
REG4	83998	broad.mit.edu	37	1	120337248	120337248	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:120337248C>T	uc001eig.2	-	7	910	c.470G>A	c.(469-471)CGA>CAA	p.R157Q	REG4_uc001eif.2_Missense_Mutation_p.R157Q	NM_001159352	NP_001152824	Q9BYZ8	REG4_HUMAN	regenerating islet-derived family, member 4	157						extracellular region	sugar binding	p.R157*(1)		ovary(1)	1	all_cancers(5;4.81e-10)|all_epithelial(5;7.98e-11)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;8.1e-07)|Lung NSC(69;5.89e-06)|all_epithelial(167;0.000959)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0588)		GCTCTATGGTCGGTACTTGCA	0.428000													14	195					0	0	0	0
VPS72	6944	broad.mit.edu	37	1	151156861	151156861	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:151156861C>T	uc001exe.1	-	4	537	c.494G>A	c.(493-495)CGG>CAG	p.R165Q	VPS72_uc001exf.1_Missense_Mutation_p.R165Q	NM_005997	NP_005988	Q15906	VPS72_HUMAN	transcription factor-like 1	165	Potential.				chromatin modification|negative regulation of transcription from RNA polymerase II promoter	nucleus|protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|pancreas(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGTTAGTGGCCGCTCACAGTG	0.537000													12	157					0	0	0	0
LCE2D	353141	broad.mit.edu	37	1	152636834	152636834	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:152636834C>T	uc001fag.2	+	2	308	c.253C>T	c.(253-255)CGG>TGG	p.R85W		NM_178430	NP_848517	Q5TA82	LCE2D_HUMAN	late cornified envelope 2D	85	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCACCGGCGCCGGCACCAGAG	0.682000													8	86					0	0	0	0
KCNH1	3756	broad.mit.edu	37	1	210857106	210857106	+	Silent	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:210857106G>A	uc001hib.2	-	11	2657	c.2487C>T	c.(2485-2487)GGC>GGT	p.G829G	KCNH1_uc001hic.2_Silent_p.G802G	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	829	Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TGGCACAATCGCCCCCGCCCC	0.642000													13	89					0	0	0	0
AKT3	10000	broad.mit.edu	37	1	243736284	243736284	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:243736284T>C	uc001iab.1	-	8	844	c.763A>G	c.(763-765)ATT>GTT	p.I255V	AKT3_uc001hzz.1_Missense_Mutation_p.I255V	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	255	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			GCAGAGACAATTTCTGCACCA	0.413000													12	40					0	0	0	0
PIP4K2A	5305	broad.mit.edu	37	10	22898587	22898587	+	Silent	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr10:22898587G>A	uc001irl.3	-	2	452	c.204C>T	c.(202-204)GCC>GCT	p.A68A		NM_005028	NP_005019	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	68	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			ovary(1)|skin(1)	2						TTTTTGAATAGGCTTTGAAGT	0.353000													7	53					0	0	0	0
KIAA1462	57608	broad.mit.edu	37	10	30315782	30315782	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr10:30315782G>A	uc001iux.2	-	2	3354	c.3295C>T	c.(3295-3297)CTC>TTC	p.L1099F	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.L961F|KIAA1462_uc009xle.1_Missense_Mutation_p.L1099F	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1099										ovary(4)	4						CCCGGCAGGAGGGACTCCACC	0.627000													9	105					0	0	0	0
LOC642826	642826	broad.mit.edu	37	10	47207813	47207813	+	RNA	SNP	T	C	C			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr10:47207813T>C	uc001jei.2	-	12		c.1586A>G			uc009xnf.2_Missense_Mutation_p.H132R					Homo sapiens cDNA, FLJ99065.												0						TTTACTTACATGGTTTGTACA	0.294000													7	21					0	0	0	0
ANK3	288	broad.mit.edu	37	10	62023666	62023666	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr10:62023666G>A	uc001jky.2	-	6	818	c.626C>T	c.(625-627)GCG>GTG	p.A209V	ANK3_uc010qih.1_Missense_Mutation_p.A192V|ANK3_uc001jkz.3_Missense_Mutation_p.A203V|ANK3_uc001jlb.1_5'UTR	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	209	ANK 5.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTTTCGGGCCGCGATATGAAG	0.552000													12	51					0	0	0	0
C10orf54	64115	broad.mit.edu	37	10	73521632	73521632	+	Silent	SNP	G	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr10:73521632G>T	uc001jsd.2	-	2	375	c.234C>A	c.(232-234)GGC>GGA	p.G78G	CDH23_uc001jrx.3_Intron|C10orf54_uc001jse.2_5'UTR|C10orf54_uc009xqm.2_Intron|C10orf54_uc001jsf.1_Silent_p.G78G	NM_022153	NP_071436	Q9H7M9	GI24_HUMAN	platelet receptor Gi24 precursor	78	Ig-like.|Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TCTGCACCTCGCCCCTCGAGC	0.647000													5	47					0.000602214	0.00315233	1	0
PSD	5662	broad.mit.edu	37	10	104164346	104164346	+	Silent	SNP	G	C	C			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr10:104164346G>C	uc001kvg.1	-	15	3221	c.2694C>G	c.(2692-2694)CTC>CTG	p.L898L	PSD_uc001kve.1_Silent_p.L106L|PSD_uc001kvf.1_Silent_p.L267L|PSD_uc001kvh.1_Silent_p.L519L|PSD_uc009xxd.1_Silent_p.L898L	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	898	Potential.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		CTACCTGGGAGAGGCGGGTGG	0.532000													3	66					0	0	0	0
ZNF143	7702	broad.mit.edu	37	11	9500065	9500065	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr11:9500065G>A	uc001mhr.2	+	6	620	c.502G>A	c.(502-504)GGT>AGT	p.G168S	ZNF143_uc009yfu.2_Missense_Mutation_p.G167S|ZNF143_uc010rby.1_Missense_Mutation_p.G137S	NM_003442	NP_003433	P52747	ZN143_HUMAN	zinc finger protein 143	168					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)		GACAGTGGCAGGTCTGCACAC	0.493000													8	90					0	0	0	0
LRP4	4038	broad.mit.edu	37	11	46898166	46898166	+	Silent	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr11:46898166G>A	uc001ndn.3	-	25	3533	c.3387C>T	c.(3385-3387)CTC>CTT	p.L1129L		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1129	Extracellular (Potential).|LDL-receptor class B 11.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		CATCAACCGCGAGCCCATCTG	0.537000													11	85					0	0	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130278733	130278733	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr11:130278733G>T	uc001qgg.3	-	7	2211	c.1853C>A	c.(1852-1854)TCC>TAC	p.S618Y	ADAMTS8_uc001qgf.2_Missense_Mutation_p.S99Y	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	618	Cys-rich.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		GTCCCGGGGGGACACCCCAGC	0.562000													14	111					2.32078e-09	1.32975e-08	1	0
TULP3	7289	broad.mit.edu	37	12	3048518	3048518	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr12:3048518G>A	uc010seh.1	+	11	1318	c.1237G>A	c.(1237-1239)GTG>ATG	p.V413M	TULP3_uc009zec.1_Missense_Mutation_p.V140M|TULP3_uc010seg.1_RNA|TULP3_uc001qlj.2_Missense_Mutation_p.V413M|TULP3_uc010sei.1_Missense_Mutation_p.V237M	NM_003324	NP_003315	O75386	TULP3_HUMAN	tubby like protein 3 isoform 1	413					G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding				0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GGCAGATGACGTGTTCACACT	0.428000													11	112					0	0	0	0
SPRYD3	84926	broad.mit.edu	37	12	53471030	53471030	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr12:53471030G>T	uc001sbt.1	-	2	60	c.39C>A	c.(37-39)AAC>AAA	p.N13K	SPRYD3_uc010snw.1_5'UTR	NM_032840	NP_116229	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	13										central_nervous_system(1)	1						CATCCATCTTGTTCATGAGAA	0.547000													7	26					1.06961e-07	5.88982e-07	1	0
SSH1	54434	broad.mit.edu	37	12	109194621	109194621	+	Silent	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr12:109194621G>A	uc001tnm.2	-	12	1170	c.1083C>T	c.(1081-1083)TAC>TAT	p.Y361Y	SSH1_uc001tnl.2_Silent_p.Y49Y|SSH1_uc010sxg.1_Silent_p.Y372Y|SSH1_uc001tnn.3_Silent_p.Y361Y	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	361	Tyrosine-protein phosphatase.				actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						TCTCTTCATCGTAGACTCGGA	0.398000													14	114					0	0	0	0
ACACB	32	broad.mit.edu	37	12	109617746	109617746	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr12:109617746G>A	uc001tob.2	+	11	1791	c.1672G>A	c.(1672-1674)GTG>ATG	p.V558M	ACACB_uc001toc.2_Missense_Mutation_p.V558M	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	558	Biotin carboxylation.|ATP-grasp.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GGCCAAGACCGTGGGCTATGT	0.527000													6	53					0	0	0	0
ATP12A	479	broad.mit.edu	37	13	25265211	25265211	+	Silent	SNP	G	A	A	rs61739266	byFrequency	TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr13:25265211G>A	uc001upp.2	+	8	1078	c.891G>A	c.(889-891)ACG>ACA	p.T297T	ATP12A_uc010aaa.2_Silent_p.T303T	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	297	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	ATGAGAAGACGCCCATTGCCA	0.522000													9	69					0	0	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328670	88328670	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr13:88328670C>T	uc001vln.2	+	2	1246	c.1027C>T	c.(1027-1029)CGC>TGC	p.R343C	SLITRK5_uc010tic.1_Missense_Mutation_p.R102C	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	343	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GCCCAGGGTGCGCCCCACCTC	0.597000													8	93					0	0	0	0
EML5	161436	broad.mit.edu	37	14	89206756	89206756	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr14:89206756A>G	uc001xxg.2	-	6	872	c.686T>C	c.(685-687)ATA>ACA	p.I229T		NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	229	WD 4.					cytoplasm|microtubule				ovary(3)	3						TATTGTTCGTATAAGATTGAT	0.363000													5	47					0	0	0	0
PKD1	5310	broad.mit.edu	37	16	2153543	2153543	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr16:2153543T>C	uc002cos.1	-	23	8724	c.8515A>G	c.(8515-8517)ATC>GTC	p.I2839V	PKD1_uc002cot.1_Missense_Mutation_p.I2839V|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2839	Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						TAGTTGCTGATATAGCCAAAG	0.612000													7	86					0	0	0	0
ABCC1	4363	broad.mit.edu	37	16	16205306	16205306	+	Silent	SNP	C	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr16:16205306C>T	uc010bvi.2	+	22	3121	c.2946C>T	c.(2944-2946)TTC>TTT	p.F982F	ABCC1_uc010bvj.2_Silent_p.F923F|ABCC1_uc010bvk.2_Silent_p.F926F|ABCC1_uc010bvl.2_Silent_p.F982F|ABCC1_uc010bvm.2_Silent_p.F867F|ABCC1_uc002del.3_Silent_p.F876F	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	982	Helical; Name=12.|ABC transmembrane type-1 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TCTTCCTTTTCATGTGTAACC	0.537000													13	135					0	0	0	0
CHST6	4166	broad.mit.edu	37	16	75512895	75512895	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr16:75512895G>A	uc002fef.2	-	3	1012	c.832C>T	c.(832-834)CGG>TGG	p.R278W	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.R278W	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	278	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						AGCGGCTCCCGCGCCAGGTCC	0.667000													6	51					0	0	0	0
JPH3	57338	broad.mit.edu	37	16	87678468	87678468	+	Silent	SNP	G	A	A	rs150628659		TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr16:87678468G>A	uc002fkd.2	+	2	1241	c.987G>A	c.(985-987)CCG>CCA	p.P329P	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	329	Cytoplasmic (Potential).|MORN 8.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		TGACCTTCCCGGACGGCACCA	0.662000													5	60					0	0	0	0
P2RX1	5023	broad.mit.edu	37	17	3819509	3819509	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr17:3819509C>T	uc002fww.2	-	1	452	c.11G>A	c.(10-12)CGG>CAG	p.R4Q	P2RX1_uc010ckm.1_5'UTR	NM_002558	NP_002549	P51575	P2RX1_HUMAN	purinergic receptor P2X1	4	Cytoplasmic (Potential).				platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		CTCCTGGAACCGCCGTGCCAT	0.642000													17	108					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577094	7577094	+	Missense_Mutation	SNP	G	A	A	rs28934574		TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	30					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578212	7578212	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr17:7578212G>A	uc002gim.2	-	6	831	c.637C>T	c.(637-639)CGA>TGA	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.2_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.1_Nonsense_Mutation_p.R174*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R81*(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			4	28					0	0	0	0
COASY	80347	broad.mit.edu	37	17	40714773	40714773	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr17:40714773A>G	uc002hzz.2	+	2	290	c.133A>G	c.(133-135)ATG>GTG	p.M45V	COASY_uc010cyj.2_Missense_Mutation_p.M74V|COASY_uc002iab.2_Intron|COASY_uc002iad.2_Missense_Mutation_p.M45V|COASY_uc002iac.2_Missense_Mutation_p.M45V|COASY_uc002iae.2_5'Flank	NM_001042529	NP_001035994	Q13057	COASY_HUMAN	coenzyme A synthase isoform a	45					coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity				0		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		GCAGCCGGGCATGAGCCTGGA	0.662000													5	86					0	0	0	0
AXIN2	8313	broad.mit.edu	37	17	63537655	63537655	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr17:63537655C>T	uc002jfi.2	-	4	1266	c.977G>A	c.(976-978)CGT>CAT	p.R326H	AXIN2_uc010den.1_Missense_Mutation_p.R326H|AXIN2_uc002jfh.2_Missense_Mutation_p.R326H	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	326					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						ACTGCCCACACGATAAGGAGG	0.478000									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				11	85					0	0	0	0
SMAD4	4089	broad.mit.edu	37	18	48581208	48581208	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr18:48581208C>T	uc010xdp.1	+	5	1050	c.512C>T	c.(511-513)TCG>TTG	p.S171L	SMAD4_uc010xdo.1_RNA|SMAD4_uc002lfb.3_Missense_Mutation_p.S16L	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	171					BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(3)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		GGACAGCCATCGTTGTCCACT	0.398000									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				5	51					0	0	0	0
SMAD4	4089	broad.mit.edu	37	18	48581281	48581281	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr18:48581281C>G	uc010xdp.1	+	5	1123	c.585C>G	c.(583-585)TAC>TAG	p.Y195*	SMAD4_uc010xdo.1_RNA|SMAD4_uc002lfb.3_Nonsense_Mutation_p.Y40*	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	195					BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(3)|p.Y195fs*1(1)|p.Y195*(1)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		CAGAGACATACAGCACCCCAG	0.483000									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				10	88					0	0	0	0
RPS28	6234	broad.mit.edu	37	19	8386936	8386936	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr19:8386936C>G	uc002mjn.2	+	3	218	c.187C>G	c.(187-189)CGA>GGA	p.R63G	NDUFA7_uc002mjm.1_5'Flank	NM_001031	NP_001022	P62857	RS28_HUMAN	ribosomal protein S28	63					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|structural constituent of ribosome				0						GGAGTCAGAGCGAGAAGCCCG	0.592000													3	17					0	0	0	0
CYP4F8	11283	broad.mit.edu	37	19	15739591	15739591	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr19:15739591C>A	uc002nbi.2	+	14	1399	c.1335C>A	c.(1333-1335)TTC>TTA	p.F445L	CYP4F8_uc010xoj.1_Missense_Mutation_p.F257L	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	445					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						CCTTCCGCTTCGACCCAGAAA	0.602000													10	59					4.84862e-15	2.81618e-14	1	0
ZNF30	90075	broad.mit.edu	37	19	35435248	35435248	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr19:35435248G>T	uc010edp.1	+	5	1756	c.1378G>T	c.(1378-1380)GAA>TAA	p.E460*	ZNF30_uc002nxf.2_Nonsense_Mutation_p.E379*|ZNF30_uc010edq.1_Nonsense_Mutation_p.E461*|ZNF30_uc010edr.1_Nonsense_Mutation_p.E461*	NM_194325	NP_919306	P17039	ZNF30_HUMAN	zinc finger protein 30 isoform b	460	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		TGAGTGTAAGGAATGTGGCAA	0.428000													7	41					2.7689e-08	1.54475e-07	1	0
PIH1D1	55011	broad.mit.edu	37	19	49949860	49949860	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr19:49949860G>A	uc002pns.2	-	8	1063	c.779C>T	c.(778-780)CCG>CTG	p.P260L	uc002pnr.1_5'Flank	NM_017916	NP_060386	Q9NWS0	PIHD1_HUMAN	NOP17	260					box C/D snoRNP assembly	pre-snoRNP complex					0		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00152)|GBM - Glioblastoma multiforme(486;0.0244)		GATCTGCAGCGGGATATAAGC	0.632000													10	101					0	0	0	0
Unknown	0	broad.mit.edu	37	2	38709227	38709227	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr2:38709227C>G	uc002rqu.1	+	1	302	c.235C>G	c.(235-237)CTG>GTG	p.L79V						SubName: Full=RPLP0 protein;																		GGAGAAACTGCTGCCTCATAT	0.577000													7	57					0	0	0	0
PSME4	23198	broad.mit.edu	37	2	54119989	54119989	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr2:54119989T>C	uc002rxp.2	-	36	4203	c.4147A>G	c.(4147-4149)ATA>GTA	p.I1383V	PSME4_uc010yop.1_Missense_Mutation_p.I1269V|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Missense_Mutation_p.I758V|PSME4_uc010fbv.1_Missense_Mutation_p.I527V	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	1383	HEAT 4.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AAACCAGCTATAATTTCTGCA	0.383000													4	69					0	0	0	0
MARCO	8685	broad.mit.edu	37	2	119726797	119726797	+	Silent	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr2:119726797G>A	uc002tln.1	+	2	291	c.159G>A	c.(157-159)CTG>CTA	p.L53L	MARCO_uc010yyf.1_5'UTR	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	53	Helical; Signal-anchor for type II membrane protein; (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						TCATCTACCTGATCCTGCTCA	0.597000													9	73					0	0	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135920601	135920601	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr2:135920601G>T	uc002tuj.2	+	22	2561	c.2536G>T	c.(2536-2538)GCT>TCT	p.A846S	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.A846S|RAB3GAP1_uc010fng.2_Missense_Mutation_p.A671S|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	846						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		CATTGCCAGAGCTCGGTCACT	0.423000													11	110					7.03913e-09	3.97945e-08	1	0
MYL1	4632	broad.mit.edu	37	2	211179749	211179749	+	Silent	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr2:211179749G>A	uc002vec.2	-	1	147	c.18C>T	c.(16-18)GAC>GAT	p.D6D		NM_079420	NP_524144	P05976	MYL1_HUMAN	fast skeletal myosin alkali light chain 1	6					muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			ovary(1)	1				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		GTTTCTTCACGTCTTTCTTTG	0.323000													29	234					0	0	0	0
ANKZF1	55139	broad.mit.edu	37	2	220098566	220098566	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr2:220098566G>A	uc002vkg.2	+	8	1123	c.949G>A	c.(949-951)GGG>AGG	p.G317R	ANKZF1_uc010zkv.1_Missense_Mutation_p.G261R|ANKZF1_uc010zkw.1_Missense_Mutation_p.G107R|ANKZF1_uc002vkh.2_Missense_Mutation_p.G107R|ANKZF1_uc002vki.2_Missense_Mutation_p.G317R|ANKZF1_uc002vkj.1_Missense_Mutation_p.G305R	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	317						intracellular	zinc ion binding	p.G317V(1)		ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTGCAAAGGGGGGATCCCCG	0.597000													7	60					0	0	0	0
NRIP1	8204	broad.mit.edu	37	21	16339480	16339480	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr21:16339480A>G	uc002yjx.2	-	4	1632	c.1034T>C	c.(1033-1035)GTG>GCG	p.V345A		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	345					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		ATTTTGAAACACTGTAGCACT	0.393000													12	73					0	0	0	0
INPP5J	27124	broad.mit.edu	37	22	31522415	31522415	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr22:31522415C>T	uc003aju.3	+	3	1417	c.1325C>T	c.(1324-1326)ACA>ATA	p.T442I	INPP5J_uc010gwf.2_Missense_Mutation_p.T442I|INPP5J_uc003ajv.3_Missense_Mutation_p.T75I|INPP5J_uc003ajs.3_Missense_Mutation_p.T75I|INPP5J_uc011alk.1_Missense_Mutation_p.T375I|INPP5J_uc010gwg.2_Missense_Mutation_p.T7I|INPP5J_uc003ajw.2_5'UTR|INPP5J_uc003ajt.3_Missense_Mutation_p.T74I|INPP5J_uc003ajx.2_5'Flank|INPP5J_uc003ajy.2_5'Flank|INPP5J_uc003ajz.2_5'Flank	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	442	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						GACGATGTCACATCCCTCCTC	0.637000													10	141					0	0	0	0
SFI1	9814	broad.mit.edu	37	22	32007798	32007798	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr22:32007798G>A	uc003ale.2	+	24	2855	c.2462G>A	c.(2461-2463)CGG>CAG	p.R821Q	SFI1_uc003alf.2_Missense_Mutation_p.R790Q|SFI1_uc003alg.2_Missense_Mutation_p.R739Q|SFI1_uc011alp.1_Missense_Mutation_p.R727Q|SFI1_uc011alq.1_Missense_Mutation_p.R766Q|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA|SFI1_uc003ali.2_5'Flank|SFI1_uc003alj.2_5'Flank	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	821					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						AGACTCAGCCGGACCTGCTTC	0.617000													5	39					0	0	0	0
GLB1	2720	broad.mit.edu	37	3	33038739	33038739	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr3:33038739G>A	uc003cfi.1	-	16	1949	c.1832C>T	c.(1831-1833)TCG>TTG	p.S611L	GLB1_uc003cfh.1_Missense_Mutation_p.S581L|GLB1_uc003cfj.1_Missense_Mutation_p.S480L|GLB1_uc011axk.1_Missense_Mutation_p.S659L	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	611					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				GTTTGGGGCCGAGGTCATCAG	0.572000													7	66					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	G	G	rs121913279		TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378000	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			8	50					0	0	0	0
MUC4	4585	broad.mit.edu	37	3	195517442	195517442	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr3:195517442G>C	uc011bto.1	-	2	1469	c.1009C>G	c.(1009-1011)CAA>GAA	p.Q337E	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.Q219E	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	342					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTGTTGATTTGAGATACTCTG	0.458000													17	215					0	0	0	0
DRD5	1816	broad.mit.edu	37	4	9784380	9784380	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr4:9784380G>A	uc003gmb.3	+	1	1123	c.727G>A	c.(727-729)GTG>ATG	p.V243M		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	243	Helical; Name=5; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CATCATGATCGTGACCTACAC	0.607000													8	45					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187560905	187560905	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr4:187560905G>A	uc003izf.2	-	4	3801	c.3613C>T	c.(3613-3615)CGA>TGA	p.R1205*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1205	Extracellular (Potential).|Cadherin 10.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGCTGTTCTCGGTCTAGCTTC	0.308000										HNSCC(5;0.00058)			12	76					0	0	0	0
PARP8	79668	broad.mit.edu	37	5	50057654	50057654	+	Splice_Site	SNP	G	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr5:50057654G>T	uc003jon.3	+	7	528	c.346_splice	c.e7-1	p.E116_splice	PARP8_uc011cpz.1_Splice_Site_p.E8_splice|PARP8_uc003joo.2_Splice_Site_p.E116_splice|PARP8_uc003jop.2_Splice_Site_p.E116_splice	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8							intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				ATTATTTTAAGGAATCAAGAC	0.333000													6	62					2.0095e-06	1.09234e-05	1	0
SLC36A1	206358	broad.mit.edu	37	5	150867642	150867642	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr5:150867642G>A	uc003luc.2	+	11	1475	c.1258G>A	c.(1258-1260)GAG>AAG	p.E420K	GM2A_uc011dcs.1_Intron	NM_078483	NP_510968	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 member 1	420	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			skin(1)	1		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	ACCGCTCCTGGAGGTCACCAC	0.627000													4	38					0	0	0	0
EEF1E1	9521	broad.mit.edu	37	6	8080226	8080226	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:8080226T>C	uc003mxz.2	-	4	496	c.422A>G	c.(421-423)AAT>AGT	p.N141S	EEF1E1_uc011dic.1_Intron	NM_004280	NP_004271	O43324	MCA3_HUMAN	eukaryotic translation elongation factor 1	141	GST C-terminal.				negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of DNA damage response, signal transduction by p53 class mediator|tRNA aminoacylation for protein translation	cytosol|nucleus					0	Ovarian(93;0.0398)					GCGAGACACATTAAGATATTT	0.368000													3	70					0	0	0	0
HIVEP1	3096	broad.mit.edu	37	6	12161735	12161735	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:12161735A>G	uc003nac.2	+	8	6730	c.6551A>G	c.(6550-6552)GAT>GGT	p.D2184G	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	2184					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GATGGCCCAGATGAGGATGAC	0.453000													9	74					0	0	0	0
HIST1H1C	3006	broad.mit.edu	37	6	26056552	26056552	+	Silent	SNP	C	T	T	rs139532972	byFrequency	TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:26056552C>T	uc003nfw.2	-	1	148	c.105G>A	c.(103-105)GCG>GCA	p.A35A		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	35					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						GGGGACCAGACGCCTTACGAG	0.632000													9	91					0	0	0	0
MDN1	23195	broad.mit.edu	37	6	90380712	90380712	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:90380712A>G	uc003pnn.1	-	83	13998	c.13882T>C	c.(13882-13884)TCT>CCT	p.S4628P		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4628					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTTGCTAAAGACATGGTCAGG	0.532000													4	81					0	0	0	0
PLAGL1	5325	broad.mit.edu	37	6	144263171	144263171	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:144263171T>C	uc003qjv.2	-	3	2048	c.782A>G	c.(781-783)CAT>CGT	p.H261R	PLAGL1_uc003qjx.2_Missense_Mutation_p.H261R|PLAGL1_uc003qjy.2_Missense_Mutation_p.H261R|PLAGL1_uc010khl.2_Missense_Mutation_p.H261R|PLAGL1_uc010khm.2_Missense_Mutation_p.H261R|PLAGL1_uc003qjz.2_Missense_Mutation_p.H261R|PLAGL1_uc003qka.2_Missense_Mutation_p.H261R|PLAGL1_uc003qkb.2_Missense_Mutation_p.H209R|PLAGL1_uc003qkc.2_Missense_Mutation_p.H261R|PLAGL1_uc003qkd.2_Missense_Mutation_p.H209R|PLAGL1_uc003qke.2_Missense_Mutation_p.H261R|PLAGL1_uc003qkf.2_Missense_Mutation_p.H261R|PLAGL1_uc003qkg.2_Missense_Mutation_p.H209R|PLAGL1_uc003qkh.2_Missense_Mutation_p.H261R|PLAGL1_uc003qki.2_Missense_Mutation_p.H209R|PLAGL1_uc003qkj.2_Missense_Mutation_p.H261R|PLAGL1_uc003qkk.2_Missense_Mutation_p.H209R|PLAGL1_uc003qkl.2_Missense_Mutation_p.H209R|PLAGL1_uc003qkm.2_Missense_Mutation_p.H261R|PLAGL1_uc010khn.2_Missense_Mutation_p.H261R|PLAGL1_uc003qkn.2_Missense_Mutation_p.H209R|PLAGL1_uc003qko.2_Missense_Mutation_p.H261R|PLAGL1_uc003qkp.2_Missense_Mutation_p.H209R|PLAGL1_uc003qjw.2_Missense_Mutation_p.H209R	NM_002656	NP_002647	Q9UM63	PLAL1_HUMAN	pleiomorphic adenoma gene-like 1 isoform 1	261					cell cycle arrest|induction of apoptosis|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(155;5.74e-07)|GBM - Glioblastoma multiforme(68;0.0885)		GGTGAGGCTATGGACCTCAGC	0.612000											OREG0017707	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	123					0	0	0	0
VIP	7432	broad.mit.edu	37	6	153073384	153073384	+	Silent	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:153073384G>A	uc003qpe.2	+	2	244	c.72G>A	c.(70-72)TCG>TCA	p.S24S	VIP_uc003qpf.2_Silent_p.S24S|VIP_uc010kjd.2_Silent_p.S24S	NM_003381	NP_003372	P01282	VIP_HUMAN	vasoactive intestinal peptide isoform 1	24					body fluid secretion|G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation	extracellular region	neuropeptide hormone activity				0		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;4.5e-11)|BRCA - Breast invasive adenocarcinoma(81;0.144)		CACAGACTTCGGCATGGCCTC	0.463000													8	44					0	0	0	0
TIAM2	26230	broad.mit.edu	37	6	155565824	155565824	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:155565824G>A	uc003qqb.2	+	20	4723	c.3450G>A	c.(3448-3450)ATG>ATA	p.M1150I	TIAM2_uc003qqe.2_Missense_Mutation_p.M1150I|TIAM2_uc010kjj.2_Missense_Mutation_p.M683I|TIAM2_uc003qqf.2_Missense_Mutation_p.M526I|TIAM2_uc011efl.1_Missense_Mutation_p.M486I|TIAM2_uc003qqg.2_Missense_Mutation_p.M462I|TIAM2_uc003qqh.2_Missense_Mutation_p.M75I	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1150	DH.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TGCCAGAGATGCTTGAGTTTC	0.438000													8	104					0	0	0	0
MLLT4	4301	broad.mit.edu	37	6	168352492	168352492	+	Silent	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr6:168352492G>A	uc003qwd.2	+	29	4576	c.4434G>A	c.(4432-4434)CGG>CGA	p.R1478R	MLLT4_uc003qwb.1_Silent_p.R1463R|MLLT4_uc003qwc.1_Silent_p.R1479R|MLLT4_uc003qwg.1_Silent_p.R788R	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1479					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CAGTCATTCGGGAGCTGCAGC	0.577000			T	MLL	AL								8	81					0	0	0	0
RAPGEF5	9771	broad.mit.edu	37	7	22190088	22190088	+	Silent	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr7:22190088G>A	uc003svg.2	-	18	1675	c.1362C>T	c.(1360-1362)ATC>ATT	p.I454I	RAPGEF5_uc011jyl.1_Silent_p.I135I	NM_012294	NP_036426	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	304					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1						GGGATTTGGAGATGACTAAGT	0.378000													4	90					0	0	0	0
AEBP1	165	broad.mit.edu	37	7	44151908	44151908	+	Silent	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr7:44151908G>A	uc003tkb.2	+	17	2510	c.2205G>A	c.(2203-2205)TCG>TCA	p.S735S	AEBP1_uc003tkc.3_Silent_p.S310S|AEBP1_uc003tkd.2_5'UTR	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	735	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GCTACCTTTCGCCAGATGCCA	0.622000													5	42					0	0	0	0
PTPN12	5782	broad.mit.edu	37	7	77256908	77256908	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr7:77256908G>A	uc003ugh.2	+	13	2003	c.1912G>A	c.(1912-1914)GAA>AAA	p.E638K	PTPN12_uc011kgp.1_Missense_Mutation_p.E519K|PTPN12_uc011kgq.1_Missense_Mutation_p.E508K|PTPN12_uc010lds.2_Missense_Mutation_p.E370K	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	638						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						CACTAGTACTGAAAGCATTTC	0.373000													4	47					0	0	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94539551	94539551	+	Silent	SNP	A	G	G			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr7:94539551A>G	uc003unp.2	+	2	408	c.126A>G	c.(124-126)GAA>GAG	p.E42E	PPP1R9A_uc010lfj.2_Silent_p.E42E|PPP1R9A_uc011kif.1_Silent_p.E42E|PPP1R9A_uc003unq.2_Silent_p.E42E|PPP1R9A_uc011kig.1_Silent_p.E42E	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	42	Actin-binding.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			CAGATGGGGAACAAAAAACAA	0.453000										HNSCC(28;0.073)			4	32					0	0	0	0
XPO7	23039	broad.mit.edu	37	8	21857170	21857170	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr8:21857170G>T	uc003xaa.3	+	24	2869	c.2767G>T	c.(2767-2769)GGA>TGA	p.G923*	XPO7_uc010lti.2_Nonsense_Mutation_p.G932*|XPO7_uc010ltk.2_Nonsense_Mutation_p.G924*	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	923					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		CATTTCTGAAGGACTTACTGC	0.433000													5	45					3.59834e-05	0.000193126	1	0
YTHDF3	253943	broad.mit.edu	37	8	64099642	64099642	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr8:64099642G>A	uc003xuy.2	+	5	1389	c.1073G>A	c.(1072-1074)CGT>CAT	p.R358H	YTHDF3_uc010lys.2_Missense_Mutation_p.R302H|YTHDF3_uc003xuz.2_Missense_Mutation_p.R302H|YTHDF3_uc003xva.2_Missense_Mutation_p.R302H|YTHDF3_uc011len.1_Missense_Mutation_p.R302H	NM_152758	NP_689971	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	358											0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			GTAGCTCCTCGTAACAGGGGA	0.547000													7	18					0	0	0	0
MYC	4609	broad.mit.edu	37	8	128750680	128750680	+	Missense_Mutation	SNP	A	C	C			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr8:128750680A>C	uc003ysh.1	+	3	685	c.172A>C	c.(172-174)ACC>CCC	p.T58P	MYC_uc003ysi.2_Missense_Mutation_p.T73P	NM_002467	NP_002458	P01106	MYC_HUMAN	myc proto-oncogene protein	58				T->A: Impairs interaction with FBXW7 and subsequent degradation by the proteasome.	branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(3)|ovary(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		GCTGCTGCCCACCCCGCCCCT	0.677000		3	A|T	IGK@|BCL5|BCL7A |BTG1|TRA@|IGH@	Burkitt lymphoma| amplified in other cancers|B-CLL						OREG0018982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	25					0	0	0	0
COL22A1	169044	broad.mit.edu	37	8	139635989	139635989	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr8:139635989G>C	uc003yvd.2	-	52	4204	c.3757C>G	c.(3757-3759)CCC>GCC	p.P1253A	COL22A1_uc011ljo.1_Missense_Mutation_p.P533A	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1253	Pro-rich.|Gly-rich.|Collagen-like 12.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TCTCCAGGGGGACCCGGCTTT	0.388000										HNSCC(7;0.00092)			53	171					0	0	0	0
KDM4C	23081	broad.mit.edu	37	9	6893144	6893144	+	Missense_Mutation	SNP	A	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr9:6893144A>T	uc003zkh.2	+	8	1413	c.833A>T	c.(832-834)CAT>CTT	p.H278L	KDM4C_uc010mhu.2_Missense_Mutation_p.H300L|KDM4C_uc010mhw.2_Missense_Mutation_p.H278L|KDM4C_uc011lmi.1_Missense_Mutation_p.H278L|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Missense_Mutation_p.H278L|KDM4C_uc011lmk.1_Missense_Mutation_p.H97L	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	278	JmjC.	Iron; catalytic (By similarity).			positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						TATGGCTACCATGCTGGTTTT	0.368000													7	80					0	0	0	0
RUSC2	9853	broad.mit.edu	37	9	35555624	35555624	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr9:35555624G>A	uc003zww.2	+	3	2837	c.2582G>A	c.(2581-2583)CGA>CAA	p.R861Q	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.R861Q	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	861						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GGCTCCTGGCGATCTGGCCTC	0.637000													6	50					0	0	0	0
FLJ46321	389763	broad.mit.edu	37	9	84606763	84606763	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr9:84606763G>T	uc004amn.2	+	4	1425	c.1378G>T	c.(1378-1380)GTT>TTT	p.V460F		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	460						integral to membrane					0						CTCAATTGCTGTTAAGCATGA	0.418000													11	73					3.86212e-05	0.000204692	1	0
IARS	3376	broad.mit.edu	37	9	95004546	95004546	+	Missense_Mutation	SNP	T	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr9:95004546T>A	uc004art.1	-	29	3324	c.3067A>T	c.(3067-3069)AAT>TAT	p.N1023Y	IARS_uc004ars.1_Missense_Mutation_p.N868Y|IARS_uc004aru.3_Missense_Mutation_p.N1023Y|IARS_uc010mqr.2_Missense_Mutation_p.N913Y|IARS_uc010mqt.2_Missense_Mutation_p.N246Y	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	1023					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	ATAACACTATTCAGATATGTT	0.368000													7	33					0	0	0	0
MUSK	4593	broad.mit.edu	37	9	113563104	113563104	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr9:113563104C>T	uc004bey.2	+	14	2544	c.2446C>T	c.(2446-2448)CGA>TGA	p.R816*	MUSK_uc004bez.1_Nonsense_Mutation_p.R396*	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	816	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						TTACTACGTGCGAGATGGCAA	0.557000													4	34					0	0	0	0
OPN1LW	5956	broad.mit.edu	37	X	153421950	153421950	+	Missense_Mutation	SNP	A	T	T	rs145631912	byFrequency	TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chrX:153421950A>T	uc004fjz.3	+	5	959	c.926A>T	c.(925-927)TAC>TTC	p.Y309F		NM_020061	NP_064445	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	309	Helical; Name=7; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGCCGGCCTACTTTGCCAAA	0.537000													45	416					0	0	0	0
PUM1	9698	broad.mit.edu	37	1	31437649	31437650	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr1:31437649_31437650insA	uc001bsi.1	-	14	2307_2308	c.2194_2195insT	c.(2194-2196)TATfs	p.Y732fs	PUM1_uc001bsf.1_Frame_Shift_Ins_p.Y398fs|PUM1_uc001bsg.1_Intron|PUM1_uc001bsh.1_Frame_Shift_Ins_p.Y732fs|PUM1_uc001bsj.1_Frame_Shift_Ins_p.Y706fs|PUM1_uc010oga.1_Frame_Shift_Ins_p.Y588fs|PUM1_uc001bsk.1_Frame_Shift_Ins_p.Y768fs|PUM1_uc010ogb.1_Frame_Shift_Ins_p.Y673fs	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	732	Ser-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		AAGGCCGTTATAAAAACTGTGT	0.559													---	---	---							
Unknown	0	broad.mit.edu	37	10	11739250	11739252	+	IGR	DEL	CAC	-	-	rs7919922	by1000genomes	TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr10:11739250_11739252delCAC								USP6NL (85571 upstream) : ECHDC3 (45104 downstream)																							ttaccatatgcaccaccaccacc	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	12	3181349	3181350	+	IGR	INS	-	TT	TT			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr12:3181349_3181350insTT								TEAD4 (31508 upstream) : TSPAN9 (5207 downstream)																							TTtttttttccttttttttttt	0.317													---	---	---							
RGPD4	285190	broad.mit.edu	37	2	108488296	108488297	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr2:108488296_108488297insA	uc010ywk.1	+	20	3918_3919	c.3836_3837insA	c.(3835-3837)AGAfs	p.R1279fs	RGPD4_uc002tdu.2_Frame_Shift_Ins_p.R466fs|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1279					intracellular transport		binding			skin(2)	2						AGCCCTGTGAGAAAAAATCTTT	0.396													---	---	---							
Unknown	0	broad.mit.edu	37	5	97361477	97361478	+	IGR	INS	-	A	A	rs11954368	by1000genomes	TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr5:97361477_97361478insA								RIOK2 (842472 upstream) : RGMB (743521 downstream)																							aacagagacacaaaaaaccctt	0.000													---	---	---							
FAT2	2196	broad.mit.edu	37	5	150921902	150921902	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr5:150921902delT	uc003lue.3	-	9	8799	c.8786delA	c.(8785-8787)AAGfs	p.K2929fs	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2929	Extracellular (Potential).|Cadherin 26.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATCCAGGGTCTTTAGAGTCGC	0.493													---	---	---							
Unknown	0	broad.mit.edu	37	7	57659470	57659471	+	IGR	DEL	TA	-	-	rs79867563	by1000genomes	TCGA-CQ-6222-01A-11D-1912-08	TCGA-CQ-6222-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	de2c492f-5cd8-4330-a5de-36f693ec31af	930e8d3f-2ca9-4a88-9397-27e741a23e48	g.chr7:57659470_57659471delTA								ZNF716 (126205 upstream) : None (None downstream)																							GCGTTGATCTTACAGTCTGGTG	0.371													---	---	---							
