Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PLEKHN1	84069	broad.mit.edu	37	1	906364	906364	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:906364G>A	uc001ace.2	+	5	745	c.710G>A	c.(709-711)CGC>CAC	p.R237H	PLEKHN1_uc001acd.2_Missense_Mutation_p.R197H|PLEKHN1_uc001acf.2_Missense_Mutation_p.R197H	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	237											0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		GGGCCGCGGCGCTGCCACTCG	0.736000													5	10					0	0	0	0
TARDBP	23435	broad.mit.edu	37	1	11082376	11082376	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:11082376G>A	uc001art.2	+	6	1044	c.910G>A	c.(910-912)GGT>AGT	p.G304S	TARDBP_uc010oap.1_Missense_Mutation_p.G188S	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	304	Gly-rich.				3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		AAACAATCAAGGTAGTAATAT	0.498000													6	60					0	0	0	0
HIVEP3	59269	broad.mit.edu	37	1	41978886	41978886	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:41978886T>A	uc001cgz.3	-	8	7219	c.6006A>T	c.(6004-6006)GAA>GAT	p.E2002D	HIVEP3_uc001cha.3_Missense_Mutation_p.E2002D|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	2002					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGGCCTGTGGTTCTCGGGCCG	0.632000													30	44					0	0	0	0
HIVEP3	59269	broad.mit.edu	37	1	42050284	42050284	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:42050284G>A	uc001cgz.3	-	4	1398	c.185C>T	c.(184-186)CCC>CTC	p.P62L	HIVEP3_uc001cha.3_Missense_Mutation_p.P62L|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	62					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AACTGATGAGGGGCCCGGGAA	0.622000													46	76					0	0	0	0
C8B	732	broad.mit.edu	37	1	57422503	57422503	+	Silent	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:57422503A>G	uc001cyp.2	-	3	397	c.330T>C	c.(328-330)TGT>TGC	p.C110C	C8B_uc010oon.1_Silent_p.C48C|C8B_uc010ooo.1_Silent_p.C58C	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	110	TSP type-1 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TGTTGGTAACACAGTCTTCGA	0.498000													28	222					0	0	0	0
LRRC40	55631	broad.mit.edu	37	1	70616847	70616847	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:70616847A>T	uc001der.1	-	13	1533	c.1481T>A	c.(1480-1482)CTG>CAG	p.L494Q		NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	494	LRR 16.									ovary(1)	1						CAGTCTTACCAGTGATTCCAT	0.284000													10	19					0	0	0	0
C1orf173	127254	broad.mit.edu	37	1	75038758	75038758	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:75038758T>C	uc001dgg.2	-	14	2855	c.2636A>G	c.(2635-2637)CAA>CGA	p.Q879R		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	879	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CATCAAGGCTTGCTTTTCAGG	0.527000													72	156					0	0	0	0
HFM1	164045	broad.mit.edu	37	1	91859650	91859650	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:91859650C>G	uc001doa.3	-	4	594	c.494G>C	c.(493-495)AGA>ACA	p.R165T	HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Missense_Mutation_p.R165T	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	165							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		taataattaCCTTTTCCGGAA	0.284000													9	10					0	0	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94669495	94669495	+	Silent	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:94669495A>G	uc001dqj.3	-	8	1122	c.753T>C	c.(751-753)ATT>ATC	p.I251I	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Silent_p.I251I	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	251					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		CCTGAATTCCAATGTTAGTTC	0.338000													7	26					0	0	0	0
LPPR4	9890	broad.mit.edu	37	1	99772018	99772018	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:99772018A>C	uc001dse.2	+	7	1850	c.1744A>C	c.(1744-1746)ATG>CTG	p.M582L	LPPR4_uc010oue.1_Missense_Mutation_p.M524L	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	582							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AGTCATAGCCATGTCCAAGCA	0.537000													23	47					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103400075	103400075	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:103400075C>T	uc001dul.2	-	46	3848	c.3530G>A	c.(3529-3531)GGG>GAG	p.G1177E	COL11A1_uc001duk.2_Missense_Mutation_p.G373E|COL11A1_uc001dum.2_Missense_Mutation_p.G1189E|COL11A1_uc001dun.2_Missense_Mutation_p.G1138E|COL11A1_uc009weh.2_Missense_Mutation_p.G1061E	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1177	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCCAAACATCCCCTGCTGTCC	0.448000													16	49					0	0	0	0
LOC645166	645166	broad.mit.edu	37	1	148933289	148933289	+	Splice_Site	SNP	A	G	G	rs9729175	by1000genomes	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:148933289A>G	uc010pbc.1	+	3		c.236_splice	c.e3-2		LOC645166_uc010pbd.1_Intron|LOC645166_uc009wkw.1_Splice_Site	NR_027355				Homo sapiens cDNA, FLJ18771.												0						TGCTGCCCGCAGGATATTGTG	0.562000													3	11					0	0	0	0
SV2A	9900	broad.mit.edu	37	1	149876628	149876628	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:149876628G>A	uc001etg.2	-	13	2658	c.2167C>T	c.(2167-2169)CTT>TTT	p.L723F	SV2A_uc009wlk.2_Missense_Mutation_p.L175F	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	723	Helical; (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CCAAGGGCAAGGGCAGCTGAG	0.602000													7	27					0	0	0	0
ARNT	405	broad.mit.edu	37	1	150808901	150808901	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:150808901C>A	uc001evr.1	-	7	698	c.555G>T	c.(553-555)AGG>AGT	p.R185S	ARNT_uc001evs.1_Missense_Mutation_p.R170S|ARNT_uc009wmb.1_Missense_Mutation_p.R176S|ARNT_uc009wmc.1_Missense_Mutation_p.R185S|ARNT_uc009wmd.1_Missense_Mutation_p.R170S|ARNT_uc009wme.1_Missense_Mutation_p.R185S|ARNT_uc010pcl.1_Missense_Mutation_p.R169S	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	185	PAS 1.				positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			CATACACCACCCTGCCTGTCT	0.453000			T	ETV6	AML								11	40					3.86212e-05	0.000146906	1	0
LASS2	29956	broad.mit.edu	37	1	150941485	150941485	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:150941485G>A	uc001evy.2	-	2	469	c.82C>T	c.(82-84)CGA>TGA	p.R28*	LASS2_uc001evz.2_Nonsense_Mutation_p.R28*|LASS2_uc009wmh.2_Intron	NM_181746	NP_859530	Q96G23	CERS2_HUMAN	LAG1 longevity assurance 2	28	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0	all_lung(15;8.07e-35)|Lung NSC(24;7.93e-31)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CGTCCATCTCGGTCTTCTAGA	0.527000													8	47					0	0	0	0
CD1D	912	broad.mit.edu	37	1	158152775	158152775	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:158152775A>T	uc001frr.2	+	5	1214	c.715A>T	c.(715-717)ATG>TTG	p.M239L	CD1D_uc009wss.2_Intron	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	239	Ig-like.|Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					GGTGAAGTGGATGCGGGGTGA	0.627000													10	133					0	0	0	0
CD84	8832	broad.mit.edu	37	1	160520798	160520798	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:160520798G>C	uc001fwh.3	-	6	863	c.839C>G	c.(838-840)ACA>AGA	p.T280R	CD84_uc001fwf.3_Missense_Mutation_p.T263R|CD84_uc001fwg.3_Missense_Mutation_p.T274R|CD84_uc009wtn.2_Intron|CD84_uc001fwi.3_Missense_Mutation_p.T149R	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	280	Cytoplasmic (Potential).|ITSM motif 1.				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CATGATATATGTGTATATGGT	0.383000													20	318					0	0	0	0
RXRG	6258	broad.mit.edu	37	1	165398200	165398200	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:165398200G>A	uc001gda.2	-	2	353	c.53C>T	c.(52-54)TCC>TTC	p.S18F		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	18	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	GTGGCCAGGGGAGCCTGTAAG	0.567000													18	22					0	0	0	0
LGR6	59352	broad.mit.edu	37	1	202287594	202287594	+	Silent	SNP	G	A	A	rs140182035		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:202287594G>A	uc001gxu.2	+	18	2163	c.2163G>A	c.(2161-2163)GCG>GCA	p.A721A	LGR6_uc001gxv.2_Silent_p.A669A|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Silent_p.A582A	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	721	Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						TGCCCTACGCGCCACCTGAGG	0.667000													10	33					0	0	0	0
PPFIA4	8497	broad.mit.edu	37	1	203008176	203008176	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:203008176C>T	uc009xaj.2	+	6	481	c.481C>T	c.(481-483)CTG>TTG	p.L161L				O75335	LIPA4_HUMAN	SubName: Full=Liprin alpha4;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						GGGGGACCGCCTGGGTCCCCC	0.622000											OREG0014109	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	11					0	0	0	0
TMCC2	9911	broad.mit.edu	37	1	205238351	205238351	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:205238351C>T	uc001hbz.1	+	4	1465	c.1021C>T	c.(1021-1023)CAG>TAG	p.Q341*	TMCC2_uc010prf.1_Nonsense_Mutation_p.Q263*|TMCC2_uc001hca.2_Nonsense_Mutation_p.Q116*|TMCC2_uc001hcb.1_Nonsense_Mutation_p.Q101*|TMCC2_uc001hcc.1_5'UTR|TMCC2_uc001hcd.2_Nonsense_Mutation_p.Q108*	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	341	Potential.					integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GAAGAAGAACCAGAAGTCAGC	0.592000													4	45					0	0	0	0
IL19	29949	broad.mit.edu	37	1	206972269	206972269	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:206972269A>T	uc001heo.2	+	1	55	c.30A>T	c.(28-30)AGA>AGT	p.R10S		NM_153758	NP_715639	Q9UHD0	IL19_HUMAN	interleukin 19 isoform 1 precursor	Error:Variant_position_missing_in_Q9UHD0_after_alignment					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(75;0.211)			TTCCGCACAGATCTGCGTGTT	0.478000													34	80					0	0	0	0
LYST	1130	broad.mit.edu	37	1	235904812	235904812	+	Silent	SNP	G	A	A	rs141534829	byFrequency	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:235904812G>A	uc001hxj.2	-	31	8443	c.8268C>T	c.(8266-8268)CAC>CAT	p.H2756H	LYST_uc009xga.1_Silent_p.H392H	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2756					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CTTGTGCAGCGTGGGCTGGCG	0.438000									Chediak-Higashi_syndrome				6	94					0	0	0	0
HEATR1	55127	broad.mit.edu	37	1	236714247	236714247	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:236714247C>T	uc001hyd.1	-	45	6515	c.6390G>A	c.(6388-6390)CAG>CAA	p.Q2130Q	HEATR1_uc009xgh.1_Silent_p.Q1292Q	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	2130	HEAT.				rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTTCCAGTTGCTGAATAGTCT	0.368000													30	38					0	0	0	0
MLLT10	8028	broad.mit.edu	37	10	22021981	22021981	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:22021981C>T	uc001iqs.2	+	19	2768	c.2420C>T	c.(2419-2421)CCG>CTG	p.P807L	MLLT10_uc001iqt.2_Missense_Mutation_p.P791L|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.P791L|MLLT10_uc001ira.2_Missense_Mutation_p.P248L|MLLT10_uc001irb.2_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	807					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						AATCCTAGTCCGTCTCATCAA	0.338000			T	MLL|PICALM|CDK6	AL								7	67					0	0	0	0
RASSF4	83937	broad.mit.edu	37	10	45484754	45484754	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:45484754G>A	uc001jbo.2	+	7	698	c.564G>A	c.(562-564)GTG>GTA	p.V188V	RASSF4_uc001jbp.2_Silent_p.V219V|RASSF4_uc009xmn.2_Silent_p.V118V|RASSF4_uc001jbq.2_Silent_p.V85V|RASSF4_uc001jbt.2_Silent_p.V145V	NM_032023	NP_114412	Q9H2L5	RASF4_HUMAN	Ras association domain family 4	188	Ras-associating.				cell cycle|signal transduction		protein binding			large_intestine(1)	1						ATGGATCCGTGACCAATGTGA	0.562000													11	31					0	0	0	0
ANXA2P3	305	broad.mit.edu	37	10	66585883	66585883	+	RNA	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:66585883G>A	uc009xpm.1	+	1		c.599G>A				NR_001446				Human lipocortin (LIP) 2 pseudogene mRNA, complete cds-like region.												0						TGGCTCTGTCGTTGATTATGA	0.458000													11	15					0	0	0	0
MYPN	84665	broad.mit.edu	37	10	69925475	69925475	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:69925475G>A	uc001jnm.3	+	10	1685	c.1500G>A	c.(1498-1500)TTG>TTA	p.L500L	MYPN_uc001jnl.1_Silent_p.L500L|MYPN_uc001jnn.3_Silent_p.L225L|MYPN_uc001jno.3_Silent_p.L500L|MYPN_uc009xps.2_Silent_p.L500L|MYPN_uc009xpt.2_Silent_p.L500L|MYPN_uc010qit.1_Silent_p.L206L|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	500	Interaction with CARP.|Ig-like 2.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						TTTGCACCTTGGTCATTGCTG	0.413000													5	44					0	0	0	0
RUFY2	55680	broad.mit.edu	37	10	70139220	70139220	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:70139220G>C	uc001job.2	-	12	1598	c.1271C>G	c.(1270-1272)ACC>AGC	p.T424S	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joa.2_5'Flank|RUFY2_uc001joc.2_Missense_Mutation_p.T355S|RUFY2_uc010qiw.1_Missense_Mutation_p.T331S|RUFY2_uc001jod.1_Missense_Mutation_p.T389S	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	438	Potential.					nucleus	metal ion binding			ovary(1)	1						AATTTTATTGGTTTTTTCTTC	0.274000													8	64					0	0	0	0
TTC18	118491	broad.mit.edu	37	10	75059376	75059376	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:75059376C>T	uc009xrc.2	-	14	1635	c.1514G>A	c.(1513-1515)GGA>GAA	p.G505E	TTC18_uc001jty.2_Missense_Mutation_p.G505E|TTC18_uc009xrd.1_Missense_Mutation_p.G319E|TTC18_uc001jtx.2_5'Flank	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	505							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					CTGAGCTCCTCCTGTCCGACG	0.353000													14	27					0	0	0	0
BTRC	8945	broad.mit.edu	37	10	103291078	103291078	+	Silent	SNP	A	T	T	rs146435684		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:103291078A>T	uc001kta.2	+	7	941	c.828A>T	c.(826-828)ATA>ATT	p.I276I	BTRC_uc001ktb.2_Silent_p.I240I|BTRC_uc001ktc.2_Silent_p.I250I	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	276					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		CTAAAATTATACAAGACATTG	0.368000													24	50					0	0	0	0
POLL	27343	broad.mit.edu	37	10	103343337	103343337	+	Silent	SNP	G	A	A	rs148400497	byFrequency	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:103343337G>A	uc001ktg.1	-	5	1759	c.993C>T	c.(991-993)AGC>AGT	p.S331S	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_5'Flank|POLL_uc001kte.1_Silent_p.S23S|POLL_uc001kth.1_Silent_p.S56S|POLL_uc001kti.1_Silent_p.S331S|POLL_uc001ktj.1_Silent_p.S331S|POLL_uc001ktf.2_Silent_p.S239S|POLL_uc001ktk.1_Silent_p.S70S|POLL_uc010qqa.1_Silent_p.S70S|POLL_uc010qqb.1_RNA|POLL_uc001ktm.2_Silent_p.S331S|POLL_uc001ktl.2_Silent_p.S243S|POLL_uc010qqc.1_Silent_p.S23S|POLL_uc010qqd.1_3'UTR	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	331					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		AGACAGGCACGCTCTCACTGA	0.562000								DNA_polymerases_(catalytic_subunits)					15	29					0	0	0	0
C10orf81	79949	broad.mit.edu	37	10	115534710	115534710	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:115534710C>A	uc001lat.1	+	9	1449	c.887C>A	c.(886-888)TCC>TAC	p.S296Y	C10orf81_uc001lar.1_Missense_Mutation_p.S302Y|C10orf81_uc009xyc.1_Missense_Mutation_p.S214Y|C10orf81_uc001las.1_Missense_Mutation_p.S214Y|C10orf81_uc001lau.1_Missense_Mutation_p.S116Y	NM_024889	NP_079165	Q5SXH7	CJ081_HUMAN	hypothetical protein LOC79949	296										central_nervous_system(1)	1		Colorectal(252;0.175)		Epithelial(162;0.0181)|all cancers(201;0.0204)		TGGTGTCTTTCCCCTGCCGAT	0.488000													12	28					0.00010058	0.000381145	1	0
GRK5	2869	broad.mit.edu	37	10	121182709	121182709	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:121182709A>C	uc001led.2	+	5	604	c.371A>C	c.(370-372)GAC>GCC	p.D124A	GRK5_uc009xzh.2_Missense_Mutation_p.D19A|GRK5_uc010qta.1_Missense_Mutation_p.D19A	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	124	N-terminal.|RGS.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		GTTGGCCAAGACCTGGTCTCC	0.582000													51	152					0	0	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122280508	122280508	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:122280508T>A	uc001lev.1	+	5	698	c.346T>A	c.(346-348)TGC>AGC	p.C116S	PPAPDC1A_uc010qtd.1_Missense_Mutation_p.C116S|PPAPDC1A_uc009xzl.1_Intron|PPAPDC1A_uc001lew.1_Intron|PPAPDC1A_uc001lex.1_Intron|PPAPDC1A_uc001ley.1_Intron	NM_001030059	NP_001025230	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain	116					phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)	1		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		CTTTTACCGCTGCTTTCCAGA	0.512000													21	57					0	0	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	A	A	rs121913233		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:533874T>A	uc001lpv.2	-	3	370	c.182A>T	c.(181-183)CAG>CTG	p.Q61L	HRAS_uc010qvw.1_Missense_Mutation_p.Q61L|HRAS_uc010qvx.1_Missense_Mutation_p.Q61L|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	61	GTP.		Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).	Q->V: Strongly increased transformation of cultured cell lines.|Q->I: Moderately increased transformation of cultured cell lines.	activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(112)|p.Q61L(93)|p.Q61K(39)|p.Q61H(20)|p.Q61P(3)|p.Q61Q(1)|p.Q61E(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(NCIH1915_LUNG)|Q61L(KYSE30_OESOPHAGUS)	6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			22	55					0	0	0	0
EPS8L2	64787	broad.mit.edu	37	11	720677	720677	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:720677G>A	uc001lqt.2	+	6	655	c.408G>A	c.(406-408)CTG>CTA	p.L136L	EPS8L2_uc010qwj.1_Silent_p.L152L|EPS8L2_uc001lqu.2_Silent_p.L136L|EPS8L2_uc010qwk.1_Silent_p.L152L|EPS8L2_uc001lqv.2_Silent_p.L91L|EPS8L2_uc001lqw.2_5'Flank|EPS8L2_uc001lqx.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	136	PID.					cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CGTCTGTGCTGCTGCTCGTGT	0.582000													5	7					0	0	0	0
EIF3M	10480	broad.mit.edu	37	11	32615476	32615476	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:32615476G>T	uc001mtu.2	+	6	641	c.598G>T	c.(598-600)GCT>TCT	p.A200S	EIF3M_uc010ref.1_Missense_Mutation_p.A68S	NM_006360	NP_006351	Q7L2H7	EIF3M_HUMAN	eukaryotic translation initiation factor 3,	200						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)|breast(1)|skin(1)	3	Breast(20;0.109)					TGCTTCCCAGGCTCGAGTTGA	0.393000													13	25					0.000219431	0.000828415	1	0
C11orf48	79081	broad.mit.edu	37	11	62439187	62439187	+	5'Flank	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:62439187C>T	uc001nue.2	-						C11orf48_uc001nuf.2_5'UTR|C11orf48_uc010rmd.1_5'UTR|C11orf83_uc001nui.3_5'UTR	NM_024099	NP_077004	Q9BQE6	CK048_HUMAN	hypothetical protein LOC79081												0						GGGGAGCTCCCGTGGGCGCTC	0.657000													9	40					0	0	0	0
C11orf84	144097	broad.mit.edu	37	11	63585325	63585325	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:63585325C>A	uc001nxt.2	+	2	412	c.176C>A	c.(175-177)GCA>GAA	p.A59E		NM_138471	NP_612480	Q9BUA3	CK084_HUMAN	hypothetical protein LOC144097	59											0						CCGCTAGAGGCAGGCAGTGAT	0.637000													4	12					2.56e-06	1.008e-05	1	0
KRTAP5-10	387273	broad.mit.edu	37	11	71277066	71277066	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:71277066T>C	uc001oqt.1	+	1	458	c.433T>C	c.(433-435)TGT>CGT	p.C145R		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	145	3.|7 X 4 AA repeats of C-C-X-P.					keratin filament				skin(1)	1						GTGCAATTGCTGTAAGCCctg	0.348000													47	102					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92532912	92532912	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:92532912C>T	uc001pdj.3	+	9	6750	c.6733C>T	c.(6733-6735)CCT>TCT	p.P2245S		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2245	Cadherin 20.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGTTGTTAGCCCTTTGGATTA	0.438000										TCGA Ovarian(4;0.039)			7	16					0	0	0	0
HEPHL1	341208	broad.mit.edu	37	11	93806191	93806191	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:93806191T>G	uc001pep.2	+	7	1390	c.1233T>G	c.(1231-1233)AGT>AGG	p.S411R	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	411	Plastocyanin-like 3.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GTCTTTTCAGTGACTCTGATC	0.368000													8	21					0	0	0	0
CADM1	23705	broad.mit.edu	37	11	115102137	115102137	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:115102137G>A	uc001ppi.3	-	4	627	c.498C>T	c.(496-498)TGC>TGT	p.C166C	CADM1_uc001ppf.3_Silent_p.C166C|CADM1_uc001ppk.3_Silent_p.C166C|CADM1_uc001ppj.3_Silent_p.C166C|CADM1_uc001ppl.2_Silent_p.C166C	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	166	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		CCATAGCAGTGCAGTTGACTT	0.458000													29	56					0	0	0	0
BSX	390259	broad.mit.edu	37	11	122852272	122852272	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:122852272C>T	uc010rzs.1	-	1	108	c.108G>A	c.(106-108)GTG>GTA	p.V36V		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	36											0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		GGTCTGGGGCCACCTCTCTCA	0.612000													3	4					0	0	0	0
OR6T1	219874	broad.mit.edu	37	11	123814471	123814471	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:123814471G>T	uc010sab.1	-	1	75	c.75C>A	c.(73-75)TTC>TTA	p.F25L		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GGAACACCAGGAACTGTATGA	0.488000													36	74					5.43694e-19	2.42497e-18	1	0
Unknown	0	broad.mit.edu	37	11	124121200	124121200	+	IGR	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:124121200T>A								OR8G2 (24890 upstream) : OR8D1 (58537 downstream)																							ATTCATGTAGTTGCAGCCATC	0.463000													27	60					0	0	0	0
B4GALNT3	283358	broad.mit.edu	37	12	666883	666883	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:666883G>A	uc001qii.1	+	16	2490	c.2490G>A	c.(2488-2490)GAG>GAA	p.E830E	B4GALNT3_uc001qik.1_Silent_p.E379E	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	830	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			ATAGCAGTGAGGACATGGATG	0.522000													14	21					0	0	0	0
SOX5	6660	broad.mit.edu	37	12	23999030	23999030	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:23999030G>A	uc001rfw.2	-	3	470	c.368C>T	c.(367-369)TCC>TTC	p.S123F	SOX5_uc001rfx.2_Missense_Mutation_p.S110F|SOX5_uc001rfy.2_Missense_Mutation_p.S110F|SOX5_uc010siv.1_Missense_Mutation_p.S110F|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.S75F|SOX5_uc001rga.2_Missense_Mutation_p.S88F	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	123					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						ACTAGACAAGGACTCGCCACT	0.493000													33	53					0	0	0	0
FAR2	55711	broad.mit.edu	37	12	29469874	29469874	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:29469874G>A	uc001ris.3	+	9	1203	c.1056G>A	c.(1054-1056)TGG>TGA	p.W352*	FAR2_uc001rit.2_Nonsense_Mutation_p.W352*|FAR2_uc009zjm.2_Nonsense_Mutation_p.W255*|uc001riu.1_Intron	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	352					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0						CACAGTACTGGAATGCGGTCA	0.498000													17	215					0	0	0	0
LRRK2	120892	broad.mit.edu	37	12	40748281	40748281	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:40748281T>A	uc001rmg.3	+	45	6878	c.6757T>A	c.(6757-6759)TTT>ATT	p.F2253I	LRRK2_uc009zjw.2_Missense_Mutation_p.F1091I|LRRK2_uc001rmi.2_Missense_Mutation_p.F1086I	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2253					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTGCAATTCCTTTTCCAAGCA	0.373000													8	20					0	0	0	0
OR8S1	341568	broad.mit.edu	37	12	48920192	48920192	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:48920192C>G	uc010slu.1	+	1	778	c.778C>G	c.(778-780)CTC>GTC	p.L260V		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCTCCGCCATCTCATGCCAAA	0.498000													22	49					0	0	0	0
HOXC9	3225	broad.mit.edu	37	12	54396248	54396248	+	Silent	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:54396248C>A	uc001sep.2	+	3	671	c.573C>A	c.(571-573)TCC>TCA	p.S191S	HOXC9_uc001seq.2_Silent_p.S191S	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	191					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						ACGCCCGCTCCACGAGGAAGA	0.567000													6	109					5.18039e-06	2.03184e-05	1	0
CDK4	1019	broad.mit.edu	37	12	58142978	58142978	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:58142978G>A	uc001spv.2	-	7	1033	c.806C>T	c.(805-807)GCA>GTA	p.A269V	CDK4_uc010ssb.1_Missense_Mutation_p.A149V|CDK4_uc001spw.2_RNA|uc010ssc.1_5'Flank	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	269	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CAGCAGCTGTGCTCCCGACTC	0.602000			Mis			melanoma 			Hereditary_Melanoma				18	74					0	0	0	0
GLIPR1	11010	broad.mit.edu	37	12	75889388	75889388	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:75889388G>A	uc001sxs.2	+	4	713	c.565G>A	c.(565-567)GGA>AGA	p.G189R	GLIPR1_uc009zsb.1_Silent_p.E212E	NM_006851	NP_006842	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1 precursor	189					cellular lipid metabolic process	extracellular region|integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3						ATATAAGAGAGGAGCCACCTG	0.378000													3	24					0	0	0	0
C12orf12	196477	broad.mit.edu	37	12	91348312	91348312	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:91348312G>T	uc001tbj.2	-	1	642	c.208C>A	c.(208-210)CAG>AAG	p.Q70K		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	70										central_nervous_system(1)|pancreas(1)	2						GGGCCGTGCTGTTGCTTCGGC	0.642000													12	16					1.08611e-07	4.34443e-07	1	0
TMEM132B	114795	broad.mit.edu	37	12	126138423	126138424	+	Missense_Mutation	DNP	GA	TG	TG			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr12:126138423_126138424GA>TG	uc001uhe.1	+	9	2412_2413	c.2404_2405GA>TG	c.(2404-2406)GAT>TGT	p.D802C	TMEM132B_uc001uhf.1_Missense_Mutation_p.D314C	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	802	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AGGCAGCAATGATATTGAGGGC	0.475000													6	57					0	0	0	0
N6AMT2	221143	broad.mit.edu	37	13	21331600	21331600	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:21331600C>T	uc001uno.1	-	2	219	c.138G>A	c.(136-138)GAG>GAA	p.E46E	N6AMT2_uc009zzr.1_Silent_p.E46E|N6AMT2_uc001unp.2_RNA	NM_174928	NP_777588	Q8WVE0	N6MT2_HUMAN	N-6 adenine-specific DNA methyltransferase 2	46							methyltransferase activity|nucleic acid binding				0		all_cancers(29;5.91e-19)|all_epithelial(30;1.42e-15)|all_lung(29;5.9e-14)|Lung SC(185;0.0367)		all cancers(112;0.000234)|Epithelial(112;0.000471)|OV - Ovarian serous cystadenocarcinoma(117;0.0111)|Lung(94;0.0161)|LUSC - Lung squamous cell carcinoma(192;0.0431)		TTACCCAATTCTCTTCTATTA	0.418000													23	57					0	0	0	0
STARD13	90627	broad.mit.edu	37	13	33703125	33703125	+	Silent	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:33703125A>G	uc001uuw.2	-	5	1815	c.1689T>C	c.(1687-1689)CCT>CCC	p.P563P	STARD13_uc001uuu.2_Silent_p.P555P|STARD13_uc001uuv.2_Silent_p.P445P|STARD13_uc001uux.2_Silent_p.P528P|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Silent_p.P548P	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	563					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		TGACCCCAGGAGGCTCAGATT	0.473000													18	32					0	0	0	0
LRCH1	23143	broad.mit.edu	37	13	47315858	47315859	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:47315858_47315859GG>TT	uc001vbj.2	+	19	2298_2299	c.2062_2063GG>TT	c.(2062-2064)GGG>TTG	p.G688L	LRCH1_uc001vbk.2_Missense_Mutation_p.G723L|LRCH1_uc001vbl.3_Intron	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	688	CH.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		GCTGGCACTCGGGGAGAAAGCC	0.515000													8	419					0	0	0	0
Unknown	0	broad.mit.edu	37	13	64321346	64321346	+	RNA	SNP	T	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:64321346T>G	uc010thk.1	+	1		c.387T>G								Homo sapiens hypothetical LOC647264, mRNA (cDNA clone MGC:189721 IMAGE:9057045), complete cds.																		AGAGGACAATTTGCTTCTAAA	0.333000													6	16					0	0	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368987	86368987	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:86368987C>T	uc001vll.1	-	2	2116	c.1657G>A	c.(1657-1659)GAC>AAC	p.D553N	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	553	LRRCT 2.|Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TCCTTTTTGTCGAGATGCCCG	0.458000													11	54					0	0	0	0
OXGR1	27199	broad.mit.edu	37	13	97639754	97639754	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:97639754G>T	uc001vmx.1	-	4	504	c.260C>A	c.(259-261)CCC>CAC	p.P87H	OXGR1_uc010afr.1_Missense_Mutation_p.P87H	NM_080818	NP_543008	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	87	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			AATCAGGAAGGGGAGGCTGGT	0.453000													10	16					2.17888e-05	8.41497e-05	1	0
OR4K5	79317	broad.mit.edu	37	14	20389043	20389043	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:20389043C>A	uc010tkw.1	+	1	278	c.278C>A	c.(277-279)TCT>TAT	p.S93Y		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GAGACCATATCTTTCAGTGGC	0.418000													57	295					8.99859e-20	4.03137e-19	1	0
NOVA1	4857	broad.mit.edu	37	14	26918046	26918046	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:26918046T>A	uc001wpy.2	-	5	961	c.643A>T	c.(643-645)AAC>TAC	p.N215Y	NOVA1_uc001wpz.2_Missense_Mutation_p.N191Y|NOVA1_uc001wqa.2_Missense_Mutation_p.N93Y	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	218	KH 2.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		TCTTGCAAGTTGATCCCATCA	0.488000													43	76					0	0	0	0
BAZ1A	11177	broad.mit.edu	37	14	35245154	35245154	+	Missense_Mutation	SNP	C	T	T	rs116485187	by1000genomes	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:35245154C>T	uc001wsk.2	-	18	3372	c.2804G>A	c.(2803-2805)CGT>CAT	p.R935H	BAZ1A_uc001wsl.2_Missense_Mutation_p.R903H	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	935					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TTCAGAAAAACGGGCTAGCTG	0.353000													10	29					0	0	0	0
Unknown	0	broad.mit.edu	37	14	66479779	66479779	+	Silent	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:66479779T>C	uc001xit.2	-	1	854	c.729A>G	c.(727-729)AGA>AGG	p.R243R						SubName: Full=Nuclease sensitive element binding protein-1;																		GAGGAGGGCCTCTGCGGAATC	0.522000													5	74					0	0	0	0
SLC8A3	6547	broad.mit.edu	37	14	70633784	70633784	+	Silent	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:70633784C>A	uc001xly.2	-	2	2110	c.1356G>T	c.(1354-1356)ACG>ACT	p.T452T	SLC8A3_uc001xlw.2_Silent_p.T452T|SLC8A3_uc001xlx.2_Silent_p.T452T|SLC8A3_uc001xlz.2_Silent_p.T452T|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	452	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCAGAACCACCGTGCCCTCTG	0.488000													45	106					1.7489e-18	7.76606e-18	1	0
SLC8A3	6547	broad.mit.edu	37	14	70634902	70634902	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:70634902A>G	uc001xly.2	-	2	992	c.238T>C	c.(238-240)TAT>CAT	p.Y80H	SLC8A3_uc001xlw.2_Missense_Mutation_p.Y80H|SLC8A3_uc001xlx.2_Missense_Mutation_p.Y80H|SLC8A3_uc001xlz.2_Missense_Mutation_p.Y80H|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	80	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GCCACAAAATAGACAATGACC	0.522000													12	24					0	0	0	0
PTPN21	11099	broad.mit.edu	37	14	88940131	88940131	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:88940131G>A	uc001xwv.3	-	14	2858	c.2527C>T	c.(2527-2529)CGA>TGA	p.R843*	PTPN21_uc010twc.1_Nonsense_Mutation_p.R639*	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	843						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						GCATCTACTCGAGTCTTTTTC	0.398000													5	41					0	0	0	0
TECPR2	9895	broad.mit.edu	37	14	102900897	102900897	+	Silent	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:102900897G>T	uc001ylw.1	+	9	1891	c.1743G>T	c.(1741-1743)CTG>CTT	p.L581L	TECPR2_uc010awl.2_Silent_p.L581L|TECPR2_uc010txx.1_Intron	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	581							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						GGCGGGAGCTGCTCAATGGAG	0.532000													11	30					1.58986e-06	6.28464e-06	1	0
ADAM6	8755	broad.mit.edu	37	14	107042588	107042588	+	RNA	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr14:107042588G>T	uc010tyt.1	-	148		c.7029C>A								Parts of antibodies, mostly variable regions.												0						TCCAGAGGCTGCACAGGAGAG	0.597000													26	54					3.7963e-18	1.66377e-17	1	0
SNURF	8926	broad.mit.edu	37	15	25213157	25213157	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:25213157C>T	uc001ywu.2	+	3	315	c.189C>T	c.(187-189)TTC>TTT	p.F63F	SNRPN_uc001ywp.1_5'UTR|SNRPN_uc001ywq.1_5'UTR|SNRPN_uc001ywr.1_5'UTR|SNRPN_uc001yws.1_Intron|SNRPN_uc001ywt.1_5'UTR|SNRPN_uc001ywv.1_5'UTR|SNRPN_uc001yww.1_5'UTR|SNRPN_uc001ywx.1_5'UTR|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_RNA|SNRPN_uc001ywy.1_Silent_p.F63F	NM_022804	NP_073715	Q9Y675	SNURF_HUMAN	SNRPN upstream reading frame protein	63						nucleus					0		all_cancers(20;1.4e-21)|Breast(32;0.000625)		all cancers(64;3.48e-07)|Epithelial(43;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0142)		GGCAGGCATTCTTAGCTGAGA	0.468000													4	60					0	0	0	0
PAR4	347745	broad.mit.edu	37	15	25451254	25451254	+	RNA	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:25451254C>A	uc001yzk.1	+	10		c.1472C>A			PAR4_uc010ayo.1_Intron|SNORD115-20_uc001yzq.1_5'Flank					Homo sapiens clone Rt-13I SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0						GAGGAAGACCCCGTGGCTCTG	0.642000													13	17					7.03913e-09	2.87265e-08	1	0
ATP10A	57194	broad.mit.edu	37	15	25959362	25959362	+	Silent	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:25959362G>T	uc010ayu.2	-	10	1909	c.1803C>A	c.(1801-1803)TCC>TCA	p.S601S		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	601	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TCTTCACCGGGGACTTCAGCT	0.607000													16	31					6.31663e-08	2.54686e-07	1	0
TJP1	7082	broad.mit.edu	37	15	30003119	30003119	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:30003119G>C	uc001zcr.2	-	24	4763	c.4288C>G	c.(4288-4290)CCA>GCA	p.P1430A	TJP1_uc010azl.2_Missense_Mutation_p.P1418A|TJP1_uc001zcq.2_Missense_Mutation_p.P1354A|TJP1_uc001zcs.2_Missense_Mutation_p.P1350A	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1430	Poly-Pro.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GAGGGCAATGGAGGAGGAGGG	0.532000													76	109					0	0	0	0
TJP1	7082	broad.mit.edu	37	15	30033539	30033539	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:30033539G>A	uc001zcr.2	-	10	1727	c.1252C>T	c.(1252-1254)CTT>TTT	p.L418F	TJP1_uc010azl.2_Missense_Mutation_p.L406F|TJP1_uc001zcq.2_Missense_Mutation_p.L422F|TJP1_uc001zcs.2_Missense_Mutation_p.L418F	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	418					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TATTACCGAAGAATCCCATCT	0.338000													19	23					0	0	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42107957	42107957	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:42107957G>C	uc001zok.3	+	13	1757	c.1471G>C	c.(1471-1473)GGA>CGA	p.G491R	MAPKBP1_uc001zoj.3_Missense_Mutation_p.G485R|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Missense_Mutation_p.G485R|MAPKBP1_uc010udb.1_Missense_Mutation_p.G324R|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	491	WD 7.									central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CAGCCCCAATGGACAGCATCT	0.592000													10	26					0	0	0	0
USP8	9101	broad.mit.edu	37	15	50788056	50788056	+	Silent	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:50788056G>C	uc001zym.3	+	18	3170	c.2670G>C	c.(2668-2670)CGG>CGC	p.R890R	USP8_uc001zyl.3_Silent_p.R890R|USP8_uc001zyn.3_Silent_p.R890R|USP8_uc010ufh.1_Silent_p.R784R|uc001zyo.1_5'Flank|USP8_uc001zyp.3_Silent_p.R57R	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	890					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		CTGATAATCGGAAGAGATATA	0.318000													6	16					0	0	0	0
ALPK3	57538	broad.mit.edu	37	15	85399896	85399896	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:85399896G>T	uc002ble.2	+	6	2700	c.2533G>T	c.(2533-2535)GCT>TCT	p.A845S		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	845					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCAGGTGGATGCTGGGACACA	0.547000													9	26					5.4927e-09	2.25067e-08	1	0
MAN2A2	4122	broad.mit.edu	37	15	91455444	91455444	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:91455444A>C	uc010bnz.2	+	15	2396	c.2281A>C	c.(2281-2283)AGC>CGC	p.S761R	MAN2A2_uc002bqc.2_Missense_Mutation_p.S761R|MAN2A2_uc010uql.1_Missense_Mutation_p.S423R|MAN2A2_uc010uqm.1_Missense_Mutation_p.S340R|MAN2A2_uc010uqn.1_RNA	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	761	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			CTCTGGCACCAGCGACTTCGC	0.637000													30	66					0	0	0	0
Unknown	0	broad.mit.edu	37	15	102292797	102292797	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:102292797C>G	uc010usj.1	+	4	444	c.385C>G	c.(385-387)CCA>GCA	p.P129A	uc002bxo.2_RNA|uc002bxp.3_5'Flank|uc002bxt.2_5'Flank|uc002bxz.3_5'Flank|uc002byd.2_5'Flank|uc002bye.2_5'Flank|uc002byf.1_5'Flank|uc002byg.2_5'Flank|uc002byi.2_5'Flank|uc002byk.2_5'Flank|uc002bym.2_5'Flank|uc002byn.2_5'Flank|uc010usm.1_5'Flank					RecName: Full=Uncharacterized protein C15orf51.; Flags: Fragment;																		GAGCTGCTGTCCAACCTGCAC	0.597000													4	25					0	0	0	0
PHKB	5257	broad.mit.edu	37	16	47627442	47627442	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr16:47627442T>C	uc002eev.3	+	11	1152	c.1100T>C	c.(1099-1101)ATA>ACA	p.I367T	PHKB_uc002eeu.3_Missense_Mutation_p.I360T	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	367					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				GAATTTCCCATATTTTTCCTT	0.229000													10	18					0	0	0	0
CES2	8824	broad.mit.edu	37	16	66976677	66976677	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr16:66976677G>A	uc002eqr.2	+	10	2601	c.1601G>A	c.(1600-1602)GGG>GAG	p.G534E	CES2_uc002eqq.2_Intron|CES2_uc002eqs.2_Missense_Mutation_p.G377E	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	470					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		AGTTTCTTTGGGGGCAACTAC	0.473000													8	47					0	0	0	0
MYH8	4626	broad.mit.edu	37	17	10318656	10318656	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:10318656C>G	uc002gmm.2	-	8	789	c.694G>C	c.(694-696)GCC>CCC	p.A232P	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	232	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TTGCCAAAGGCCTCCAGTAGG	0.502000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				28	75					0	0	0	0
DNAH9	1770	broad.mit.edu	37	17	11573072	11573072	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:11573072T>G	uc002gne.2	+	17	3382	c.3314T>G	c.(3313-3315)CTC>CGC	p.L1105R	DNAH9_uc010coo.2_Missense_Mutation_p.L399R	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1105	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGGTGGAGCCTCCTGTTCAAA	0.453000													40	95					0	0	0	0
Unknown	0	broad.mit.edu	37	17	20884854	20884854	+	RNA	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:20884854A>G	uc002gyk.1	+	6		c.854A>G								Homo sapiens hypothetical protein LOC339260, mRNA (cDNA clone IMAGE:5168338), partial cds.																		GAAGAGCAGTACTGGGCTGCT	0.627000													2	7					0	0	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319765	21319765	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:21319765A>T	uc002gyv.1	+	3	1816	c.1111A>T	c.(1111-1113)AGC>TGC	p.S371C		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	371	Cytoplasmic (By similarity).			S -> R (in Ref. 2; AAC50615).	blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CCTGCTGCCCAGCGCCAACTC	0.607000										Prostate(3;0.18)			5	84					0	0	0	0
Unknown	0	broad.mit.edu	37	17	34234112	34234112	+	RNA	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:34234112G>T	uc010ctx.1	-	1		c.2842C>A								Homo sapiens cDNA FLJ43944 fis, clone TESTI4014392.																		GGGGCCGCCTGCTGGGCTGGA	0.517000													8	57					1.06961e-07	4.2955e-07	1	0
ERBB2	2064	broad.mit.edu	37	17	37881982	37881982	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:37881982G>A	uc002hso.2	+	23	2986	c.2748G>A	c.(2746-2748)ATG>ATA	p.M916I	ERBB2_uc002hsm.2_Missense_Mutation_p.M886I|ERBB2_uc010cwa.2_Missense_Mutation_p.M901I|ERBB2_uc002hsp.2_Missense_Mutation_p.M719I|ERBB2_uc010cwb.2_Missense_Mutation_p.M916I|ERBB2_uc010wek.1_Missense_Mutation_p.M640I	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	916	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GGGAGCTGATGACTTTTGGGG	0.602000		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			6	64					0	0	0	0
BRCA1	672	broad.mit.edu	37	17	41222997	41222997	+	Missense_Mutation	SNP	C	A	A	rs80357653		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:41222997C>A	uc002icq.2	-	15	5166	c.4934G>T	c.(4933-4935)AGG>ATG	p.R1645M	BRCA1_uc010whp.1_Missense_Mutation_p.R494M|BRCA1_uc010whl.1_Missense_Mutation_p.R541M|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.R1574M|BRCA1_uc002icu.2_Missense_Mutation_p.R541M|BRCA1_uc010cyx.2_Missense_Mutation_p.R1598M|BRCA1_uc002ict.2_Missense_Mutation_p.R1666M|BRCA1_uc010whn.1_Missense_Mutation_p.R136M|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Missense_Mutation_p.R374M|BRCA1_uc002idc.1_Missense_Mutation_p.R541M|BRCA1_uc010whr.1_Missense_Mutation_p.R495M	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	1645	BRCT 1.				androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TTTGTTGACCCTTTCTGTTGA	0.443000			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			59	64					3.00063e-23	1.35634e-22	1	0
ASB16	92591	broad.mit.edu	37	17	42248236	42248236	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:42248236G>C	uc002ifl.1	+	1	163	c.79G>C	c.(79-81)GAC>CAC	p.D27H	ASB16_uc002ifm.1_RNA	NM_080863	NP_543139	Q96NS5	ASB16_HUMAN	ankyrin repeat and SOCS box-containing protein	27					intracellular signal transduction		protein binding			kidney(2)	2		Breast(137;0.00765)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GGAATGGGAGGACCGGCGGCG	0.697000													10	45					0	0	0	0
SKAP1	8631	broad.mit.edu	37	17	46239901	46239901	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:46239901C>T	uc002ini.1	-	11	1020	c.908G>A	c.(907-909)TGG>TAG	p.W303*	SKAP1_uc002inj.1_Nonsense_Mutation_p.W302*|SKAP1_uc010dbd.1_Nonsense_Mutation_p.W208*|SKAP1_uc010dbe.1_Nonsense_Mutation_p.W303*	NM_003726	NP_003717	Q86WV1	SKAP1_HUMAN	src kinase associated phosphoprotein 1 isoform	303	SH3.				positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway	cytoplasm|nucleus|plasma membrane	antigen binding|protein kinase binding|SH2 domain binding				0						ATGGCAATCCCATAGGCCCTG	0.463000													12	70					0	0	0	0
HOXB2	3212	broad.mit.edu	37	17	46620658	46620658	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:46620658C>T	uc002inm.2	-	2	963	c.843G>A	c.(841-843)GGG>GGA	p.G281G		NM_002145	NP_002136	P14652	HXB2_HUMAN	homeobox B2	281					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCCGCCGGCCCCGCGCAGCG	0.711000													9	48					0	0	0	0
CA10	56934	broad.mit.edu	37	17	49726560	49726560	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:49726560G>C	uc002itw.3	-	6	1603	c.617C>G	c.(616-618)ACA>AGA	p.T206R	CA10_uc002itu.3_Missense_Mutation_p.T135R|CA10_uc002itv.3_Missense_Mutation_p.T212R|CA10_uc002itx.3_Missense_Mutation_p.T206R|CA10_uc002ity.3_Missense_Mutation_p.T206R|CA10_uc002itz.2_Missense_Mutation_p.T206R	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	206					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TGTTATTCTTGTGATAGTATC	0.284000													5	62					0	0	0	0
SCPEP1	59342	broad.mit.edu	37	17	55072947	55072947	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:55072947A>G	uc002iuv.3	+	8	790	c.737A>G	c.(736-738)TAC>TGC	p.Y246C	SCPEP1_uc010dcl.2_RNA|SCPEP1_uc010wnk.1_Missense_Mutation_p.Y196C	NM_021626	NP_067639	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1 precursor	246					proteolysis	extracellular region	serine-type carboxypeptidase activity			skin(1)	1	Breast(9;2.86e-08)					AAGGGGCTCTACAGAGAGGCC	0.498000													6	118					0	0	0	0
TTYH2	94015	broad.mit.edu	37	17	72233624	72233624	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:72233624C>T	uc002jkc.2	+	4	637	c.606C>T	c.(604-606)TCC>TCT	p.S202S	TTYH2_uc010wqw.1_Silent_p.S181S	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	202	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4						CCAAGCTATCCGACCAGACTG	0.572000													7	64					0	0	0	0
DNAI2	64446	broad.mit.edu	37	17	72285736	72285736	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:72285736C>T	uc002jkf.2	+	5	570	c.471C>T	c.(469-471)GAC>GAT	p.D157D	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	157					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						CCTGCAGGGACCCCCAGGAAA	0.483000									Kartagener_syndrome				22	34					0	0	0	0
CCDC40	55036	broad.mit.edu	37	17	78055742	78055742	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:78055742G>T	uc010dht.2	+	12	1901	c.1874G>T	c.(1873-1875)AGG>ATG	p.R625M	CCDC40_uc002jxm.3_Missense_Mutation_p.R408M|CCDC40_uc002jxn.3_Missense_Mutation_p.R21M	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	625	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CTGGAGCTCAGGAGGAAGACG	0.577000													9	36					3.09899e-07	1.22983e-06	1	0
EPB41L3	23136	broad.mit.edu	37	18	5415995	5415995	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr18:5415995G>A	uc002kmt.1	-	13	1975	c.1889C>T	c.(1888-1890)CCG>CTG	p.P630L	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Intron|EPB41L3_uc010wzf.1_Intron|EPB41L3_uc010wzg.1_Intron|EPB41L3_uc010dkr.2_Intron	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	630	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CACAAGGGACGGTGAGCGGAT	0.542000													18	59					0	0	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14797798	14797798	+	Silent	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr18:14797798A>G	uc010dlo.2	+	20	2154	c.1974A>G	c.(1972-1974)AAA>AAG	p.K658K	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	658										ovary(1)|skin(1)	2						GTGGAAGGAAAGTTTCTCTTC	0.279000													2	1					0	0	0	0
NOL4	8715	broad.mit.edu	37	18	31432903	31432903	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr18:31432903T>C	uc010dmi.2	-	11	2049	c.1820A>G	c.(1819-1821)AAT>AGT	p.N607S	NOL4_uc010xbs.1_Missense_Mutation_p.N322S|NOL4_uc002kxr.3_Missense_Mutation_p.N379S|NOL4_uc010xbt.1_Missense_Mutation_p.N533S|NOL4_uc010dmh.2_Missense_Mutation_p.N469S|NOL4_uc010xbu.1_Missense_Mutation_p.N543S|NOL4_uc002kxt.3_Missense_Mutation_p.N505S	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	607						nucleolus	RNA binding			ovary(3)	3						TCTCACGGCATTGATTTCAGT	0.468000													25	49					0	0	0	0
TSHZ1	10194	broad.mit.edu	37	18	73000493	73000493	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr18:73000493G>A	uc002lly.2	+	2	3559	c.2996G>A	c.(2995-2997)CGG>CAG	p.R999Q		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	1044	C2H2-type 5.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CTCTGCAACCGGACTTTTGCG	0.532000													24	53					0	0	0	0
APC2	10297	broad.mit.edu	37	19	1467216	1467216	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:1467216G>A	uc002lsr.1	+	15	4124	c.3916G>A	c.(3916-3918)GGG>AGG	p.G1306R	APC2_uc002lss.1_Missense_Mutation_p.G888R|APC2_uc002lst.1_Missense_Mutation_p.G1306R|APC2_uc002lsu.1_Missense_Mutation_p.G1305R|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	1306	Interaction with CTNNB1.|5 X 20 AA approximate repeat of F-X-V-E- X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-S.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGAgcgcggcgggggcgccgg	0.642000													4	11					0	0	0	0
SNAPC2	6618	broad.mit.edu	37	19	7986386	7986386	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:7986386G>A	uc002miw.1	+	2	285	c.262G>A	c.(262-264)GGA>AGA	p.G88R	SNAPC2_uc002mix.1_RNA	NM_003083	NP_003074	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex,	88					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity				0						TGGCCTTCAGGGACCAAGGCG	0.657000													21	36					0	0	0	0
SMARCA4	6597	broad.mit.edu	37	19	11105592	11105592	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:11105592C>A	uc002mqf.3	+	9	1792	c.1508C>A	c.(1507-1509)GCA>GAA	p.A503E	SMARCA4_uc010dxp.2_Missense_Mutation_p.A503E|SMARCA4_uc010dxo.2_Missense_Mutation_p.A503E|SMARCA4_uc002mqg.1_Missense_Mutation_p.A503E|SMARCA4_uc010dxq.2_Missense_Mutation_p.A503E|SMARCA4_uc010dxr.2_Missense_Mutation_p.A503E|SMARCA4_uc002mqj.3_Missense_Mutation_p.A503E|SMARCA4_uc010dxs.2_Missense_Mutation_p.A503E|SMARCA4_uc002mqe.2_Missense_Mutation_p.A503E	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	503	HSA.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CTGACCAAGGCAGTGGCCACG	0.532000			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				4	21					3.86212e-05	0.000146906	1	0
SMARCA4	6597	broad.mit.edu	37	19	11141507	11141507	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:11141507G>T	uc002mqf.3	+	25	3768	c.3484G>T	c.(3484-3486)GGC>TGC	p.G1162C	SMARCA4_uc010dxp.2_Missense_Mutation_p.G1162C|SMARCA4_uc010dxo.2_Missense_Mutation_p.G1162C|SMARCA4_uc002mqg.1_Missense_Mutation_p.G1162C|SMARCA4_uc010dxq.2_Missense_Mutation_p.G1162C|SMARCA4_uc010dxr.2_Missense_Mutation_p.G1162C|SMARCA4_uc002mqj.3_Missense_Mutation_p.G1162C|SMARCA4_uc010dxs.2_Missense_Mutation_p.G1162C|SMARCA4_uc010dxt.1_Missense_Mutation_p.G382C|SMARCA4_uc002mqh.3_Missense_Mutation_p.G285C|SMARCA4_uc002mqi.1_Missense_Mutation_p.G365C	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1162	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				TGGGGGGCTCGGCCTGAACCT	0.607000			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				6	7					3.59834e-05	0.00013844	1	0
ZNF844	284391	broad.mit.edu	37	19	12187076	12187076	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:12187076G>C	uc002mtb.2	+	4	1284	c.1141G>C	c.(1141-1143)GAC>CAC	p.D381H	ZNF844_uc010dym.1_Missense_Mutation_p.D224H	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	381					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCGTTTTGAAGACATGAAAGA	0.383000													7	21					0	0	0	0
ZNF486	90649	broad.mit.edu	37	19	20308131	20308131	+	Silent	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:20308131T>C	uc002nou.2	+	4	669	c.612T>C	c.(610-612)GAT>GAC	p.D204D		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AAAAAATTGATACTGGAGAGA	0.358000													18	38					0	0	0	0
ZNF568	374900	broad.mit.edu	37	19	37441482	37441482	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:37441482G>A	uc002ofc.2	+	7	1942	c.1427G>A	c.(1426-1428)TGC>TAC	p.C476Y	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.C400Y|ZNF568_uc010efe.2_Missense_Mutation_p.C400Y|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	476	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCTTATGAATGCAGTGAATGT	0.393000													20	61					0	0	0	0
ZNF585B	92285	broad.mit.edu	37	19	37677286	37677286	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:37677286T>A	uc002ofq.2	-	5	1407	c.1153A>T	c.(1153-1155)AGT>TGT	p.S385C	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.S199C	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	385	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCACAGTCACTGCATTCATAA	0.428000													10	56					0	0	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38652910	38652910	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:38652910C>G	uc002ohk.2	+	14	4188	c.3679C>G	c.(3679-3681)CCT>GCT	p.P1227A		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1227					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GTGGCATGTGCCTGCCCAGGC	0.582000													4	51					0	0	0	0
SERTAD1	29950	broad.mit.edu	37	19	40929342	40929342	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:40929342G>A	uc002ont.3	-	2	271	c.112C>T	c.(112-114)CCG>TCG	p.P38S		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	38	SERTA.				positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCCACGGCCGGGGGTGCCTGT	0.647000													12	21					0	0	0	0
PSG7	5676	broad.mit.edu	37	19	43433722	43433722	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:43433722T>A	uc002ovl.3	-	4	683	c.581A>T	c.(580-582)CAG>CTG	p.Q194L	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_5'Flank|PSG7_uc002out.1_Missense_Mutation_p.Q13L|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.Q72L	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	194	Ig-like C2-type 1.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				TTCAGACAGCTGCAAGCTGTG	0.512000													138	254					0	0	0	0
PRR12	57479	broad.mit.edu	37	19	50099588	50099588	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:50099588G>A	uc002poo.3	+	4	1996	c.1996G>A	c.(1996-1998)GGG>AGG	p.G666R		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GGGCGAGGACGGGGCAGCAGA	0.672000													4	11					0	0	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51633226	51633226	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:51633226G>T	uc002pvu.2	+	7	1349	c.1282G>T	c.(1282-1284)GAA>TAA	p.E428*	SIGLEC9_uc010yct.1_Intron	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	428	Cytoplasmic (Potential).				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		CTCAGTGGGGGAAGGAGAGCT	0.607000													9	77					0.000274275	0.00102777	1	0
ZNF808	388558	broad.mit.edu	37	19	53058290	53058290	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:53058290C>T	uc010epq.1	+	5	2298	c.2121C>T	c.(2119-2121)TAC>TAT	p.Y707Y	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	707	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TGAAACCTTACAAGTGTAATG	0.413000													19	250					0	0	0	0
VN1R2	317701	broad.mit.edu	37	19	53762612	53762612	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:53762612C>T	uc002qbi.2	+	1	1068	c.984C>T	c.(982-984)TAC>TAT	p.Y328Y		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	328	Helical; Name=6; (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		CATTATGTTACGCCCTTTCCT	0.443000													45	109					0	0	0	0
CACNG6	59285	broad.mit.edu	37	19	54496175	54496175	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:54496175G>C	uc002qct.2	+	1	634	c.44G>C	c.(43-45)CGG>CCG	p.R15P	CACNG6_uc002qcu.2_Missense_Mutation_p.R15P|CACNG6_uc002qcv.2_Missense_Mutation_p.R15P	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	15						voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		AAccggcggcggggggccgcg	0.562000													8	17					0	0	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55294944	55294944	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:55294944C>T	uc002qhb.1	+	7	862	c.824C>T	c.(823-825)GCG>GTG	p.A275V	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL4_uc010yfl.1_5'Flank|KIR2DL3_uc010erw.1_Missense_Mutation_p.A276V|KIR2DL1_uc002qgz.1_Missense_Mutation_p.A185V|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Missense_Mutation_p.A301V	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	275	Cytoplasmic (Potential).				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		ACAGATGCTGCGGTAATGGAC	0.517000													11	55					0	0	0	0
ZNF550	162972	broad.mit.edu	37	19	58058918	58058918	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:58058918C>G	uc002qpe.1	-	2	571	c.571G>C	c.(571-573)GAA>CAA	p.E191Q	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF550_uc002qpc.2_RNA|ZNF550_uc010eue.1_RNA|ZNF550_uc002qpd.2_RNA	NM_001039654	NP_001034743	Q7Z398	ZN550_HUMAN	zinc finger protein 550	232	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GCATTGCATTCATAGGGTTTC	0.488000													16	38					0	0	0	0
ZNF551	90233	broad.mit.edu	37	19	58198329	58198329	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr19:58198329G>A	uc002qpw.3	+	3	861	c.638G>A	c.(637-639)AGA>AAA	p.R213K	ZNF551_uc002qpv.3_Missense_Mutation_p.R156K|ZNF776_uc002qpx.2_Intron	NM_138347	NP_612356	Q7Z340	ZN551_HUMAN	zinc finger protein 551	229					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGTGAATACAGAAAAGCTTCA	0.453000													6	64					0	0	0	0
PXDN	7837	broad.mit.edu	37	2	1651956	1651956	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:1651956T>C	uc002qxa.2	-	17	3660	c.3596A>G	c.(3595-3597)GAG>GGG	p.E1199G		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1199					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TTTCAGTTTCTCCCGGATCTC	0.512000													34	202					0	0	0	0
ROCK2	9475	broad.mit.edu	37	2	11367521	11367521	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:11367521C>T	uc002rbd.1	-	6	1176	c.727G>A	c.(727-729)GGC>AGC	p.G243S		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	243	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TGTACCATGCCTGTCTGCATG	0.373000													54	130					0	0	0	0
DNMT3A	1788	broad.mit.edu	37	2	25468197	25468197	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:25468197G>A	uc002rgc.2	-	13	1736	c.1479C>T	c.(1477-1479)ATC>ATT	p.I493I	DNMT3A_uc002rgd.2_Silent_p.I493I|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Silent_p.I304I	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	493	GATA-type; atypical.|ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAGATGCAGATGTCTGGAA	0.602000			Mis|F|N|S		AML								34	36					0	0	0	0
ANKRD20B	729171	broad.mit.edu	37	2	95513821	95513821	+	RNA	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:95513821G>A	uc010fhp.2	-	5		c.584C>T				NR_003366				Homo sapiens ankyrin repeat domain 20B (ANKRD20B), non-coding RNA.												0						TGTCTTGAGCGAAGACATCAA	0.353000													43	705					0	0	0	0
RGPD4	285190	broad.mit.edu	37	2	108488441	108488441	+	Silent	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:108488441A>G	uc010ywk.1	+	20	4063	c.3981A>G	c.(3979-3981)GAA>GAG	p.E1327E	RGPD4_uc002tdu.2_Silent_p.E514E|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1327					intracellular transport		binding			skin(2)	2						TTACTCAAGAAGAAGAGAGAG	0.393000													17	233					0	0	0	0
MERTK	10461	broad.mit.edu	37	2	112786077	112786077	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:112786077A>G	uc002thk.1	+	19	2758	c.2636A>G	c.(2635-2637)GAG>GGG	p.E879G	MERTK_uc002thl.1_Missense_Mutation_p.E703G	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	879	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						CAGTTGCTGGAGAGCTCTGAG	0.522000													43	164					0	0	0	0
SLC20A1	6574	broad.mit.edu	37	2	113417263	113417263	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:113417263G>A	uc002tib.2	+	8	1977	c.1531G>A	c.(1531-1533)GTC>ATC	p.V511I	SLC20A1_uc002tic.1_Missense_Mutation_p.V323I	NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	511	Helical; (Potential).				phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2						TAAGCCTGAAGTCTCTCTCCT	0.468000													11	163					0	0	0	0
IL1F6	27179	broad.mit.edu	37	2	113764229	113764229	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:113764229G>C	uc010yxr.1	+	3	179	c.179G>C	c.(178-180)GGG>GCG	p.G60A		NM_014440	NP_055255	Q9UHA7	IL36A_HUMAN	interleukin 1 family, member 6 (epsilon)	60					immune response|inflammatory response	extracellular space	cytokine activity|interleukin-1 receptor binding				0						AAAGACAGAGGGAACCCCATC	0.527000													61	221					0	0	0	0
EN1	2019	broad.mit.edu	37	2	119603946	119603946	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:119603946C>T	uc002tlm.2	-	1	1814	c.798G>A	c.(796-798)TCG>TCA	p.S266S		NM_001426	NP_001417	Q05925	HME1_HUMAN	engrailed homeobox 1	266					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)	2						GAGGCTGCTGCGAGTCAGTTT	0.637000													5	14					0	0	0	0
ZEB2	9839	broad.mit.edu	37	2	145156077	145156077	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:145156077G>A	uc002tvu.2	-	8	3157	c.2677C>T	c.(2677-2679)CCT>TCT	p.P893S	ZEB2_uc002tvv.2_Missense_Mutation_p.P887S|ZEB2_uc010zbm.1_Missense_Mutation_p.P864S|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Missense_Mutation_p.P922S	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	893						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		GTGTATAAAGGTTTGGCACTA	0.438000													9	177					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152423805	152423805	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:152423805G>A	uc010fnx.2	-	86	13121	c.12930C>T	c.(12928-12930)GCC>GCT	p.A4310A	NEB_uc002txr.2_Silent_p.A733A	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	4310	Nebulin 118.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCTGCTTGGCGGCCAAGACTG	0.438000													52	53					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152483591	152483591	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:152483591G>C	uc010fnx.2	-	66	9734	c.9543C>G	c.(9541-9543)GAC>GAG	p.D3181E		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3181	Nebulin 86.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		ATTTCAGCTTGTCCGGAGGCT	0.488000													9	111					0	0	0	0
COL3A1	1281	broad.mit.edu	37	2	189870100	189870100	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:189870100A>T	uc002uqj.1	+	41	3073	c.2956A>T	c.(2956-2958)AAC>TAC	p.N986Y		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	986	Triple-helical region.			ANGLS -> PSGQN (in Ref. 20; AA sequence).	axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	ACCAGGAGCTAACGGTCTCAG	0.433000													52	62					0	0	0	0
NRP2	8828	broad.mit.edu	37	2	206590770	206590770	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:206590770G>T	uc002vaw.2	+	6	1745	c.954G>T	c.(952-954)TGG>TGT	p.W318C	NRP2_uc002vat.2_Missense_Mutation_p.W318C|NRP2_uc002vau.2_Missense_Mutation_p.W318C|NRP2_uc002vav.2_Missense_Mutation_p.W318C|NRP2_uc002vax.2_Missense_Mutation_p.W318C|NRP2_uc002vay.2_Missense_Mutation_p.W318C|NRP2_uc010fud.2_Missense_Mutation_p.W318C	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	318	Extracellular (Potential).|F5/8 type C 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						ACAATGGCTGGACCCCCAACT	0.522000													15	40					1.52009e-12	6.43803e-12	1	0
IKZF2	22807	broad.mit.edu	37	2	213878608	213878608	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:213878608T>C	uc002vem.2	-	7	932	c.763A>G	c.(763-765)ATT>GTT	p.I255V	IKZF2_uc010fuu.2_Missense_Mutation_p.I110V|IKZF2_uc002vej.2_Missense_Mutation_p.I202V|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Intron|IKZF2_uc002vel.2_Missense_Mutation_p.I176V|IKZF2_uc010fuw.2_Missense_Mutation_p.I29V|IKZF2_uc010fux.2_Missense_Mutation_p.I29V|IKZF2_uc010fuy.2_Missense_Mutation_p.I183V|IKZF2_uc002ven.2_Missense_Mutation_p.I229V|IKZF2_uc002vei.2_Missense_Mutation_p.I33V	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		ACCAGAGAAATATTGTTGTCC	0.388000													38	70					0	0	0	0
SLC19A3	80704	broad.mit.edu	37	2	228560704	228560704	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:228560704C>T	uc002vpi.2	-	4	1162	c.1073G>A	c.(1072-1074)GGT>GAT	p.G358D	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.G354D	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	358	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	AAATAAAGAACCGGCATTGAC	0.468000													29	86					0	0	0	0
PAK7	57144	broad.mit.edu	37	20	9561116	9561116	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr20:9561116G>A	uc002wnl.2	-	5	1211	c.666C>T	c.(664-666)GCC>GCT	p.A222A	PAK7_uc002wnk.2_Silent_p.A222A|PAK7_uc002wnj.2_Silent_p.A222A|PAK7_uc010gby.1_Silent_p.A222A	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	222	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			AGCTACTCGAGGCTCTCTGAT	0.488000													15	35					0	0	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20616166	20616166	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr20:20616166C>T	uc002wrz.2	-	9	1044	c.901G>A	c.(901-903)GTT>ATT	p.V301I	RALGAPA2_uc010gcx.2_Missense_Mutation_p.V5I|RALGAPA2_uc010zsg.1_5'UTR	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	301					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						ATAAAAACAACACGAGCTGCC	0.358000													6	121					0	0	0	0
NECAB3	63941	broad.mit.edu	37	20	32247476	32247476	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr20:32247476C>T	uc002wzn.3	-	8	812	c.706G>A	c.(706-708)GAC>AAC	p.D236N	NECAB3_uc002wzl.2_Missense_Mutation_p.D15N|NECAB3_uc002wzm.3_Missense_Mutation_p.D236N|NECAB3_uc002wzo.3_RNA|NECAB3_uc002wzp.3_Missense_Mutation_p.D187N|NECAB3_uc002wzq.3_Missense_Mutation_p.D236N|NECAB3_uc002wzr.3_RNA|NECAB3_uc010geo.2_Missense_Mutation_p.D236N|C20orf144_uc002wzs.1_5'Flank	NM_031232	NP_112509	Q96P71	NECA3_HUMAN	N-terminal EF-hand calcium binding protein 3	236					antibiotic biosynthetic process|protein metabolic process|protein secretion|regulation of amyloid precursor protein biosynthetic process	endoplasmic reticulum membrane|Golgi cis cisterna|nucleus	calcium ion binding|oxidoreductase activity|protein binding			lung(1)	1						TCGAGCTGGTCGATGAGCTCC	0.706000													4	9					0	0	0	0
CEP250	11190	broad.mit.edu	37	20	34078580	34078580	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr20:34078580C>T	uc002xcm.2	+	22	3375	c.2704C>T	c.(2704-2706)CAG>TAG	p.Q902*	CEP250_uc010zve.1_Nonsense_Mutation_p.Q270*	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	902	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GGAGGCCATCCAGGCCCAGAG	0.557000													9	77					0	0	0	0
KIAA1755	85449	broad.mit.edu	37	20	36869729	36869729	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr20:36869729G>A	uc002xhy.1	-	3	1076	c.804C>T	c.(802-804)AGC>AGT	p.S268S	KIAA1755_uc002xhz.1_Silent_p.S268S	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	268										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				CGAAGTCCTGGCTGACCACCT	0.572000													11	75					0	0	0	0
JPH2	57158	broad.mit.edu	37	20	42815270	42815270	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr20:42815270G>T	uc002xli.1	-	1	949	c.76C>A	c.(76-78)CAT>AAT	p.H26N	JPH2_uc002xlj.2_Missense_Mutation_p.H26N	NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	26	MORN 1.|Gly-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CACAGTCCATGCCCATGGGCC	0.622000													8	43					2.17888e-05	8.41497e-05	1	0
KRTAP19-7	337974	broad.mit.edu	37	21	31933565	31933565	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr21:31933565C>T	uc011adb.1	-	1	44	c.44G>A	c.(43-45)TGT>TAT	p.C15Y		NM_181614	NP_853645	Q3SYF9	KR197_HUMAN	keratin associated protein 19-7	15						intermediate filament					0						GAATCCTCCACAGCCGTAGCC	0.552000													23	75					0	0	0	0
KRTAP10-4	386672	broad.mit.edu	37	21	45993766	45993766	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr21:45993766C>A	uc002zfk.1	+	1	161	c.131C>A	c.(130-132)CCC>CAC	p.P44H	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198687	NP_941960	P60372	KR104_HUMAN	keratin associated protein 10-4	44	2.|36 X 5 AA repeats of C-C-X(3).					keratin filament					0						TGCTGCGCCCCCAGCTGCTGC	0.711000													15	27					3.8784e-16	1.67787e-15	1	0
CECR2	27443	broad.mit.edu	37	22	18031816	18031816	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr22:18031816C>T	uc010gqw.1	+	17	4438	c.4312C>T	c.(4312-4314)CCC>TCC	p.P1438S	CECR2_uc010gqv.1_Missense_Mutation_p.P1296S|CECR2_uc002zml.2_Missense_Mutation_p.P1297S|CECR2_uc002zmo.2_RNA	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	1480					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		TCCAACACTTCCCCTGGATCA	0.498000													12	32					0	0	0	0
PIWIL3	440822	broad.mit.edu	37	22	25131809	25131809	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr22:25131809G>A	uc003abd.1	-	13	1917	c.1500C>T	c.(1498-1500)CCC>CCT	p.P500P	PIWIL3_uc011ajx.1_Silent_p.P391P|PIWIL3_uc011ajy.1_Silent_p.P391P|PIWIL3_uc010gut.1_Silent_p.P500P	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	500					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						CATTAAGTAAGGGTAATTCTC	0.383000													39	103					0	0	0	0
CCDC117	150275	broad.mit.edu	37	22	29169754	29169754	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr22:29169754A>T	uc003aeb.2	+	2	403	c.227A>T	c.(226-228)GAG>GTG	p.E76V	CCDC117_uc011aki.1_Intron|CCDC117_uc011akj.1_Missense_Mutation_p.E76V|CCDC117_uc011akk.1_5'UTR	NM_173510	NP_775781	Q8IWD4	CC117_HUMAN	coiled-coil domain containing 117	76										breast(1)	1						CGAGAGGAGGAGGAGGATGAT	0.373000													9	11					0	0	0	0
TAB1	10454	broad.mit.edu	37	22	39772188	39772188	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr22:39772188T>G	uc003axr.2	+	2	2029	c.247T>G	c.(247-249)TCC>GCC	p.S83A	SYNGR1_uc003axo.3_Missense_Mutation_p.S157A|SYNGR1_uc003axp.3_Missense_Mutation_p.L123R|SYNGR1_uc003axq.3_Missense_Mutation_p.S157A|SYNGR1_uc003axs.3_Missense_Mutation_p.S158A	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	7					activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						CTCCTTTTTCTCCATCTTCAC	0.637000													35	51					0	0	0	0
CERK	64781	broad.mit.edu	37	22	47103761	47103761	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr22:47103761G>A	uc003bia.2	-	6	801	c.694C>T	c.(694-696)CGG>TGG	p.R232W	CERK_uc010hae.2_Missense_Mutation_p.R34W	NM_022766	NP_073603	Q8TCT0	CERK1_HUMAN	ceramide kinase	232	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			skin(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ATTCCAATCCGGAGGCTACTG	0.602000													16	109					0	0	0	0
MAPK11	5600	broad.mit.edu	37	22	50705870	50705870	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr22:50705870A>T	uc003bkr.2	-	4	405	c.347T>A	c.(346-348)ATC>AAC	p.I116N	MAPK11_uc010hax.2_5'UTR|MAPK11_uc011ars.1_RNA|MAPK11_uc010hay.1_RNA|MAPK11_uc011art.1_Missense_Mutation_p.H96Q|MAPK11_uc010haz.2_Missense_Mutation_p.I8N	NM_002751	NP_002742	Q15759	MK11_HUMAN	mitogen-activated protein kinase 11	116	Protein kinase.				activation of MAPK activity|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			lung(1)|breast(1)	2		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCACTTGACGATGTTGTTCAG	0.682000													9	12					0	0	0	0
ZNF385D	79750	broad.mit.edu	37	3	21706434	21706434	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:21706434G>T	uc003cce.2	-	2	517	c.109C>A	c.(109-111)CTT>ATT	p.L37I	ZNF385D_uc010hfb.1_Intron	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	37						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GGAAAGGGAAGAAATGGTTTA	0.512000													10	23					2.74318e-10	1.13325e-09	1	0
GLB1	2720	broad.mit.edu	37	3	33059966	33059966	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:33059966C>T	uc003cfi.1	-	13	1438	c.1321G>A	c.(1321-1323)GAT>AAT	p.D441N	GLB1_uc003cfh.1_Missense_Mutation_p.D411N|GLB1_uc003cfj.1_Missense_Mutation_p.D310N|GLB1_uc011axk.1_Missense_Mutation_p.D489N	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	441			D -> N (in GM1G1).		carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				TATGCTCGATCGTGGACTCCA	0.507000													16	70					0	0	0	0
ARPP21	10777	broad.mit.edu	37	3	35833960	35833960	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:35833960A>T	uc003cgb.2	+	19	2383	c.2119A>T	c.(2119-2121)AAC>TAC	p.N707Y	ARPP21_uc003cga.2_Missense_Mutation_p.N688Y|ARPP21_uc011axy.1_Missense_Mutation_p.N708Y|ARPP21_uc003cgf.2_Missense_Mutation_p.N543Y|ARPP21_uc003cgg.2_Missense_Mutation_p.N230Y	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	707	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						CGTGATAAATAACCAACAAGG	0.463000													33	61					0	0	0	0
EPM2AIP1	9852	broad.mit.edu	37	3	37033930	37033930	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:37033930G>A	uc003cgk.2	-	1	866	c.639C>T	c.(637-639)AAC>AAT	p.N213N	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	213						endoplasmic reticulum					0						GATGAGTCAGGTTGATTATGG	0.517000													6	97					0	0	0	0
CTNNB1	1499	broad.mit.edu	37	3	41267196	41267196	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:41267196C>T	uc010hia.1	+	7	936	c.780C>T	c.(778-780)CAC>CAT	p.H260H	CTNNB1_uc003ckp.2_Silent_p.H260H|CTNNB1_uc003ckq.2_Silent_p.H260H|CTNNB1_uc003ckr.2_Silent_p.H260H|CTNNB1_uc011azf.1_Silent_p.H253H|CTNNB1_uc011azg.1_Silent_p.H188H|uc010hib.1_5'Flank	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	260	ARM 3.			H->A: Abolishes or strongly reduces AXIN1 and AXIN2 binding. Strongly reduces phosphorylation and degradation; when associated with A-386 and A-383.	adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	CAACTCTCCACAACCTTTTAT	0.383000		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				54	37					0	0	0	0
CDCP1	64866	broad.mit.edu	37	3	45127378	45127378	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:45127378G>A	uc003com.2	-	9	2398	c.2263C>T	c.(2263-2265)CTG>TTG	p.L755L		NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	755	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TCTGGCTGCAGGAAGGAGCCG	0.577000													71	41					0	0	0	0
PBRM1	55193	broad.mit.edu	37	3	52637658	52637658	+	Silent	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:52637658A>G	uc003des.2	-	17	2670	c.2658T>C	c.(2656-2658)CTT>CTC	p.L886L	PBRM1_uc003dex.2_Intron|PBRM1_uc003deq.2_Silent_p.L886L|PBRM1_uc003der.2_Silent_p.L854L|PBRM1_uc003det.2_Silent_p.L901L|PBRM1_uc003deu.2_Silent_p.L901L|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Silent_p.L886L|PBRM1_uc010hmk.1_Silent_p.L886L|PBRM1_uc003dey.2_Silent_p.L886L|PBRM1_uc003dez.1_Silent_p.L886L|PBRM1_uc003dfb.1_Silent_p.L799L|PBRM1_uc003dfa.1_Silent_p.L232L	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	886					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CCGGTGAAAGAAGAATCTCTC	0.343000			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								9	29					0	0	0	0
FAM55C	91775	broad.mit.edu	37	3	101535734	101535734	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:101535734C>T	uc003dvn.2	+	7	1655	c.1018C>T	c.(1018-1020)CAG>TAG	p.Q340*	FAM55C_uc010hpn.2_Nonsense_Mutation_p.Q340*	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	340						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						TAAGATGCGTCAGTTTAATGA	0.393000													7	92					0	0	0	0
DZIP3	9666	broad.mit.edu	37	3	108353773	108353773	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:108353773G>T	uc003dxd.2	+	10	1294	c.872G>T	c.(871-873)TGC>TTC	p.C291F	DZIP3_uc003dxf.1_Missense_Mutation_p.C291F|DZIP3_uc011bhm.1_Intron|DZIP3_uc003dxe.1_Missense_Mutation_p.C291F|DZIP3_uc003dxg.1_Missense_Mutation_p.C14F	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	291					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CATAAAATTTGCTGGAAAAAG	0.264000													17	60					3.51602e-12	1.48291e-11	1	0
PLXND1	23129	broad.mit.edu	37	3	129303021	129303021	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:129303021G>A	uc003emx.2	-	7	2185	c.2085C>T	c.(2083-2085)GCC>GCT	p.A695A		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	695	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGGTGAAATTGGCCTTGACGA	0.597000													5	6					0	0	0	0
COL6A6	131873	broad.mit.edu	37	3	130380825	130380825	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:130380825G>T	uc010htl.2	+	34	6206	c.6175G>T	c.(6175-6177)GCT>TCT	p.A2059S	COL6A6_uc003eni.3_Missense_Mutation_p.A158S	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	2059	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AAATGGAGATGCTTTTATTGG	0.413000													14	42					3.27435e-08	1.32552e-07	1	0
MME	4311	broad.mit.edu	37	3	154834497	154834497	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:154834497C>G	uc010hvr.1	+	6	695	c.484C>G	c.(484-486)CCA>GCA	p.P162A	MME_uc003fab.1_Missense_Mutation_p.P162A|MME_uc003fac.1_Missense_Mutation_p.P162A|MME_uc003fad.1_Missense_Mutation_p.P162A|MME_uc003fae.1_Missense_Mutation_p.P162A	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	162	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CAAACTGTTACCAGACATATA	0.363000													7	45					0	0	0	0
SI	6476	broad.mit.edu	37	3	164727122	164727122	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:164727122G>T	uc003fei.2	-	35	4186	c.4124C>A	c.(4123-4125)GCC>GAC	p.A1375D		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1375	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AATTTCTCTGGCCCACCACTC	0.383000										HNSCC(35;0.089)			18	57					1.45105e-14	6.22408e-14	1	0
SLC2A2	6514	broad.mit.edu	37	3	170723243	170723243	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:170723243C>T	uc003fhe.1	-	7	1103	c.794G>A	c.(793-795)GGA>GAA	p.G265E	SLC2A2_uc003fhf.1_Missense_Mutation_p.G92E|SLC2A2_uc011bpu.1_Missense_Mutation_p.G138E	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	265	Cytoplasmic (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			ATCATCATATCCTCTGAGTCT	0.343000													26	58					0	0	0	0
GHSR	2693	broad.mit.edu	37	3	172165726	172165726	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:172165726C>T	uc003fib.1	-	1	478	c.478G>A	c.(478-480)GTG>ATG	p.V160M	GHSR_uc011bpv.1_Missense_Mutation_p.V160M	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	160	Cytoplasmic (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			ACCAGCTTCACCCGCCCCTTG	0.652000													6	53					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	rs104886003		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			17	62					0	0	0	0
ATP13A4	84239	broad.mit.edu	37	3	193156328	193156328	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:193156328C>G	uc003ftd.2	-	23	2716	c.2608G>C	c.(2608-2610)GCA>CCA	p.A870P	ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	870	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GCCACAGATGCCTCCTGCTCT	0.443000													25	30					0	0	0	0
LGI2	55203	broad.mit.edu	37	4	25013978	25013978	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:25013978G>A	uc003grf.2	-	7	898	c.799C>T	c.(799-801)CGG>TGG	p.R267W		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	267	EAR 2.					extracellular region					0		Breast(46;0.173)				TCATAGCTCCGGAAATTCATT	0.507000													7	103					0	0	0	0
SULT1B1	27284	broad.mit.edu	37	4	70620403	70620403	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:70620403C>A	uc003hen.2	-	3	560	c.262G>T	c.(262-264)GGA>TGA	p.G88*		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	88					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						GTTCTTAATCCAGGGAGAGTC	0.299000													28	70					9.65021e-13	4.12178e-12	1	0
PTPN13	5783	broad.mit.edu	37	4	87703369	87703369	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:87703369G>A	uc003hpz.2	+	37	6458	c.5978G>A	c.(5977-5979)GGG>GAG	p.G1993E	PTPN13_uc003hpy.2_Missense_Mutation_p.G1998E|PTPN13_uc003hqa.2_Missense_Mutation_p.G1974E|PTPN13_uc003hqb.2_Missense_Mutation_p.G1802E|PTPN13_uc003hqc.1_Missense_Mutation_p.G359E	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1993						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TACAGTGTGGGGTCTTGCAGC	0.443000													9	85					0	0	0	0
HSPA4L	22824	broad.mit.edu	37	4	128732697	128732697	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:128732697C>T	uc003ifm.2	+	12	1737	c.1484C>T	c.(1483-1485)GCA>GTA	p.A495V	HSPA4L_uc010iny.1_Missense_Mutation_p.A454V|HSPA4L_uc011cgr.1_Missense_Mutation_p.A462V	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	495					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GTGGCTAGCGCATCAGTAATT	0.368000													8	26					0	0	0	0
NAA15	80155	broad.mit.edu	37	4	140309172	140309172	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:140309172G>A	uc003ihu.1	+	20	2791	c.2535G>A	c.(2533-2535)GAG>GAA	p.E845E		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	845					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						GATATGAAGAGGATATGAAGA	0.388000													13	25					0	0	0	0
PDGFC	56034	broad.mit.edu	37	4	157689065	157689065	+	Missense_Mutation	SNP	C	T	T	rs141820181		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:157689065C>T	uc003iph.1	-	5	1272	c.781G>A	c.(781-783)GAA>AAA	p.E261K	PDGFC_uc003ipi.1_Missense_Mutation_p.E98K|PDGFC_uc011cis.1_Missense_Mutation_p.E98K|PDGFC_uc011cir.1_Missense_Mutation_p.E105K	NM_016205	NP_057289	Q9NRA1	PDGFC_HUMAN	platelet-derived growth factor C precursor	261					central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity	p.E261K(1)		ovary(1)|lung(1)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		TTTAGTTCTTCCCTTATGGAC	0.438000													38	90					0	0	0	0
ODZ3	55714	broad.mit.edu	37	4	183601503	183601503	+	Splice_Site	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:183601503G>A	uc003ivd.1	+	8	1676	c.1639_splice	c.e8+1	p.A547_splice	ODZ3_uc003ive.1_Splice_Site	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3						signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TGTTCAAGAGGTATGCAAGTT	0.443000													8	19					0	0	0	0
ING2	3622	broad.mit.edu	37	4	184432021	184432021	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:184432021G>C	uc003ivs.1	+	2	888	c.759G>C	c.(757-759)TGG>TGC	p.W253C	ING2_uc011ckk.1_Missense_Mutation_p.W213C	NM_001564	NP_001555	Q9H160	ING2_HUMAN	inhibitor of growth family, member 2	253	PHD-type.				chromatin modification|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of growth|signal transduction|transcription, DNA-dependent	CCAAT-binding factor complex|Sin3 complex	chromatin binding|DNA binding|protein complex binding|zinc ion binding	p.W253C(1)		ovary(1)	1		all_lung(41;5.16e-14)|Lung NSC(41;1.33e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|all_hematologic(60;0.0207)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		AGGGGAAATGGTATTGCCCAA	0.388000													4	30					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187557355	187557355	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:187557355G>C	uc003izf.2	-	6	4195	c.4007C>G	c.(4006-4008)TCA>TGA	p.S1336*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1336	Extracellular (Potential).|Cadherin 11.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GGTGGTTGATGACTTTTGAGG	0.418000										HNSCC(5;0.00058)			15	36					0	0	0	0
TUBB4Q	56604	broad.mit.edu	37	4	190904367	190904367	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr4:190904367C>G	uc011clg.1	-	4	616	c.613G>C	c.(613-615)GCG>CCG	p.A205P		NM_020040	NP_064424	Q99867	TBB4Q_HUMAN	tubulin, beta polypeptide 4, member Q	206					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;4.1e-31)|Epithelial(3;1.44e-30)|OV - Ovarian serous cystadenocarcinoma(60;2.03e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00839)|READ - Rectum adenocarcinoma(43;0.155)		TCATATAGCGCTTCGTTATCT	0.542000													5	67					0	0	0	0
CDH9	1007	broad.mit.edu	37	5	26903930	26903930	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:26903930G>A	uc003jgs.1	-	6	984	c.815C>T	c.(814-816)ACG>ATG	p.T272M	CDH9_uc010iug.2_Missense_Mutation_p.T272M	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	272	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						AAATTGATACGTACCTATAAA	0.318000													7	28					0	0	0	0
NAIP	4671	broad.mit.edu	37	5	70308342	70308342	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:70308342T>C	uc003kar.1	-	4	1119	c.401A>G	c.(400-402)AAC>AGC	p.N134S	NAIP_uc003kat.1_Intron|NAIP_uc011crs.1_Missense_Mutation_p.N134S|NAIP_uc003kas.1_Intron	NM_004536	NP_004527	Q13075	BIRC1_HUMAN	NLR family, apoptosis inhibitory protein isoform	134					anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		CTTGGCAATGTTACCAACATC	0.488000													36	126					0	0	0	0
NSA2	10412	broad.mit.edu	37	5	74064792	74064792	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:74064792T>A	uc003kdk.1	+	2	123	c.40T>A	c.(40-42)TAT>AAT	p.Y14N	GFM2_uc003kdh.1_5'Flank|GFM2_uc003kdi.1_5'Flank|GFM2_uc010izj.1_5'Flank|GFM2_uc010izk.1_5'Flank|GFM2_uc003kdj.1_5'Flank|GFM2_uc010izl.1_5'Flank	NM_014886	NP_055701	O95478	NSA2_HUMAN	NSA2 ribosome biogenesis homolog	14					rRNA processing	nucleolus|ribonucleoprotein complex				ovary(1)	1						CCGTAAACGCTATGGATACCG	0.328000													5	9					0	0	0	0
LIX1	167410	broad.mit.edu	37	5	96478236	96478236	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:96478236G>A	uc003kmy.3	-	1	285	c.45C>T	c.(43-45)GTC>GTT	p.V15V		NM_153234	NP_694966	Q8N485	LIX1_HUMAN	limb expression 1	15										ovary(1)	1		all_cancers(142;4.28e-07)|all_epithelial(76;1.06e-09)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0318)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.0733)		TGTGAGGCAAGACTTGGGCAA	0.453000													6	55					0	0	0	0
PGGT1B	5229	broad.mit.edu	37	5	114588910	114588910	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:114588910C>T	uc003kqw.3	-	2	204	c.183G>A	c.(181-183)TTG>TTA	p.L61L	PGGT1B_uc003kqx.3_5'UTR|PGGT1B_uc010jch.2_Silent_p.L61L	NM_005023	NP_005014	P53609	PGTB1_HUMAN	geranylgeranyltransferase type 1 beta	61					protein geranylgeranylation	CAAX-protein geranylgeranyltransferase complex	CAAX-protein geranylgeranyltransferase activity				0		all_cancers(142;0.000523)|all_epithelial(76;6.45e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		Epithelial(69;2.95e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.98e-08)|all cancers(49;3.1e-06)	Pravastatin(DB00175)	CTAAGGAATCCAACATATCCA	0.363000													11	50					0	0	0	0
ZNF608	57507	broad.mit.edu	37	5	123983042	123983042	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:123983042C>A	uc003ktq.1	-	4	3158	c.3035G>T	c.(3034-3036)GGG>GTG	p.G1012V	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Missense_Mutation_p.G1012V|ZNF608_uc003ktt.1_Missense_Mutation_p.G1012V|ZNF608_uc003ktp.1_5'Flank	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1012						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		ACCGACCTGCCCAGGGTGCAT	0.473000													46	94					8.20599e-20	3.69269e-19	1	0
SLC27A6	28965	broad.mit.edu	37	5	128351596	128351596	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:128351596C>A	uc003kuy.2	+	6	1384	c.988C>A	c.(988-990)CAT>AAT	p.H330N	SLC27A6_uc003kuz.2_Missense_Mutation_p.H330N	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	330					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		AGAAAAGGATCATAAGGTGCG	0.308000													11	30					3.86212e-05	0.000146906	1	0
IL4	3565	broad.mit.edu	37	5	132015436	132015436	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:132015436G>A	uc003kxk.1	+	3	584	c.214G>A	c.(214-216)GCT>ACT	p.A72T	IL4_uc003kxl.1_Missense_Mutation_p.A56T	NM_000589	NP_000580	P05112	IL4_HUMAN	interleukin 4 isoform 1 precursor	72					B cell differentiation|cellular defense response|chemotaxis|cholesterol metabolic process|connective tissue growth factor biosynthetic process|negative regulation of apoptosis|negative regulation of osteoclast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of interleukin-13 production|positive regulation of isotype switching to IgE isotypes|positive regulation of isotype switching to IgG isotypes|positive regulation of MHC class II biosynthetic process|positive regulation of T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|T-helper 2 cell cytokine production	extracellular space	cytokine activity|growth factor activity|interleukin-4 receptor binding				0		all_cancers(142;2.81e-05)|all_lung(232;1.47e-05)|Lung NSC(810;2.31e-05)|all_neural(839;0.0459)|Ovarian(839;0.0481)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.00245)		CTTCTGCAGGGCTGCGACTGT	0.542000													63	124					0	0	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202653	140202653	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:140202653G>A	uc003lhl.2	+	1	1293	c.1293G>A	c.(1291-1293)TCG>TCA	p.S431S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.S431S|PCDHA5_uc003lhj.1_Silent_p.S431S	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	431	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGGGGGCTCGCCTTCGCTGT	0.647000													12	150					0	0	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222342	140222342	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:140222342C>T	uc003lhs.2	+	1	1436	c.1436C>T	c.(1435-1437)GCG>GTG	p.A479V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.A479V	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	479	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGGTGTCTGCGCGAGACGCG	0.657000													32	18					0	0	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262926	140262926	+	Missense_Mutation	SNP	C	T	T	rs144000682	byFrequency	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:140262926C>T	uc003lif.2	+	1	1073	c.1073C>T	c.(1072-1074)CCC>CTC	p.P358L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.P358L|PCDHA13_uc003lid.2_Missense_Mutation_p.P358L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	358	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTCACTCCCCATCAGAGAA	0.488000													23	57					0	0	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731974	140731974	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:140731974G>T	uc003ljo.1	+	1	2147	c.2147G>T	c.(2146-2148)AGC>ATC	p.S716I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGA4_uc003ljq.1_5'Flank|PCDHGB1_uc011daq.1_Missense_Mutation_p.S716I|PCDHGA4_uc003ljp.1_5'Flank	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	716	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTTCCTCCAGCCTCGACACT	0.582000													15	147					1.52009e-12	6.43803e-12	1	0
FAM71B	153745	broad.mit.edu	37	5	156590090	156590090	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:156590090C>G	uc003lwn.2	-	2	1286	c.1186G>C	c.(1186-1188)GGA>CGA	p.G396R		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	396						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATGAGGGGTCCCACTGCTGGT	0.537000													25	34					0	0	0	0
GABRA6	2559	broad.mit.edu	37	5	161128536	161128536	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:161128536G>A	uc003lyu.2	+	9	1457	c.1119G>A	c.(1117-1119)AGG>AGA	p.R373R	GABRA6_uc003lyv.2_Silent_p.R144R	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	373	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGAAGAAAAGGATCACTTCTC	0.398000										TCGA Ovarian(5;0.080)			22	62					0	0	0	0
FGFR4	2264	broad.mit.edu	37	5	176517973	176517973	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:176517973G>C	uc003mfl.2	+	5	638	c.471G>C	c.(469-471)AAG>AAC	p.K157N	FGFR4_uc003mfm.2_Missense_Mutation_p.K157N|FGFR4_uc011dfu.1_Missense_Mutation_p.K157N|FGFR4_uc011dfv.1_RNA|FGFR4_uc003mfn.1_3'UTR|FGFR4_uc011dfw.1_Missense_Mutation_p.K157N|FGFR4_uc003mfo.2_Missense_Mutation_p.K157N	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	157	Extracellular (Potential).|Ig-like C2-type 2.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GCATGGAGAAGAAACTGCATG	0.612000										TSP Lung(9;0.080)			5	48					0	0	0	0
NSD1	64324	broad.mit.edu	37	5	176665392	176665392	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:176665392C>A	uc003mfr.3	+	7	4214	c.4076C>A	c.(4075-4077)TCA>TAA	p.S1359*	NSD1_uc003mft.3_Nonsense_Mutation_p.S1090*|NSD1_uc003mfs.1_Nonsense_Mutation_p.S1256*|NSD1_uc011dfx.1_Nonsense_Mutation_p.S1007*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1359					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TTGGCTCAGTCAGAACTTGGA	0.542000			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			78	34					1.03218e-28	4.68668e-28	1	0
N4BP3	23138	broad.mit.edu	37	5	177548532	177548532	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:177548532G>A	uc003mik.1	+	5	1412	c.1165G>A	c.(1165-1167)GCG>ACG	p.A389T	N4BP3_uc003mil.1_Missense_Mutation_p.A58T	NM_015111	NP_055926	O15049	N4BP3_HUMAN	Nedd4 binding protein 3	389	Potential.					cytoplasmic vesicle membrane					0	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGAAGCCCAGGCGGAACTGGC	0.622000													47	90					0	0	0	0
HIST1H2BG	8339	broad.mit.edu	37	6	26216840	26216840	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:26216840G>C	uc003ngz.2	-	1	33	c.32C>G	c.(31-33)CCG>CGG	p.P11R	HIST1H2AE_uc003nha.1_5'Flank	NM_003518	NP_003509	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	11					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				ACCCTTCTTCGGAGCAGGAGC	0.493000													10	113					0	0	0	0
CDSN	1041	broad.mit.edu	37	6	31084822	31084822	+	Silent	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:31084822G>T	uc003nsm.1	-	2	597	c.570C>A	c.(568-570)TCC>TCA	p.S190S	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron	NM_001264	NP_001255	Q15517	CDSN_HUMAN	corneodesmosin precursor	190	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			ovary(1)|pancreas(1)	2						GTCCAGGCTGGGAAGGGTTTA	0.557000													38	36					3.62531e-18	1.59577e-17	1	0
HSP90AB1	3326	broad.mit.edu	37	6	44217289	44217289	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:44217289C>T	uc003oxa.1	+	3	407	c.323C>T	c.(322-324)TCT>TTT	p.S108F	HSP90AB1_uc011dvr.1_Missense_Mutation_p.S108F|HSP90AB1_uc003oxb.1_Missense_Mutation_p.S108F|HSP90AB1_uc011dvs.1_5'UTR|HSP90AB1_uc003oxc.1_5'Flank	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	108					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ATTGCCAAGTCTGGTACTAAA	0.418000													9	59					0	0	0	0
TINAG	27283	broad.mit.edu	37	6	54245333	54245333	+	Silent	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:54245333A>T	uc003pcj.2	+	10	1406	c.1260A>T	c.(1258-1260)ACA>ACT	p.T420T	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	420					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			GATGGGGCACACTGAGAGGAG	0.358000													4	11					0	0	0	0
LMBRD1	55788	broad.mit.edu	37	6	70428852	70428852	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:70428852G>C	uc003pfa.2	-	8	873	c.758C>G	c.(757-759)TCA>TGA	p.S253*	LMBRD1_uc003pey.2_Nonsense_Mutation_p.S49*|LMBRD1_uc003pez.2_Nonsense_Mutation_p.S180*|LMBRD1_uc010kal.2_Nonsense_Mutation_p.S180*|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	253	Cytoplasmic (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						ACTCACTTTTGATTTAATCGT	0.353000													5	23					0	0	0	0
SENP6	26054	broad.mit.edu	37	6	76344481	76344481	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:76344481C>T	uc003pid.3	+	5	1031	c.412C>T	c.(412-414)CAT>TAT	p.H138Y	SENP6_uc003pie.3_Missense_Mutation_p.H138Y|SENP6_uc003pic.2_Missense_Mutation_p.H138Y|SENP6_uc003pif.1_Missense_Mutation_p.H29Y	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	138					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				TAGACGTTTTCATCATGCTCA	0.353000													14	32					0	0	0	0
MDN1	23195	broad.mit.edu	37	6	90384310	90384310	+	Splice_Site	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:90384310T>C	uc003pnn.1	-	79	12878	c.12762_splice	c.e79-1	p.R4254_splice		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog						protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGGAGGTTCCTGTACAGAGAA	0.507000													13	32					0	0	0	0
FUT9	10690	broad.mit.edu	37	6	96651512	96651512	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:96651512G>T	uc003pop.3	+	3	822	c.481G>T	c.(481-483)GAT>TAT	p.D161Y		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	161	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		TTACCGCCGTGATTCAGATAT	0.453000													19	35					1.1804e-14	5.08478e-14	1	0
FAM184A	79632	broad.mit.edu	37	6	119338093	119338093	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:119338093T>C	uc003pyj.2	-	5	1697	c.1349A>G	c.(1348-1350)AAG>AGG	p.K450R	FAM184A_uc003pyk.3_Missense_Mutation_p.K330R|FAM184A_uc003pyl.3_Missense_Mutation_p.K330R	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	450	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						CTGAGTTCTCTTTGCTTCATT	0.333000													11	35					0	0	0	0
KIAA1244	57221	broad.mit.edu	37	6	138566721	138566721	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:138566721G>T	uc003qhu.2	+	8	658	c.658G>T	c.(658-660)GCC>TCC	p.A220S		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	220					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GCTGCAAGCCGCCATAAAGTA	0.453000													5	14					1.23904e-05	4.82221e-05	1	0
SYNE1	23345	broad.mit.edu	37	6	152462343	152462343	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:152462343G>A	uc010kiw.2	-	139	25843	c.25241C>T	c.(25240-25242)ACG>ATG	p.T8414M	SYNE1_uc010kiv.2_Missense_Mutation_p.T2938M|SYNE1_uc003qos.3_Missense_Mutation_p.T2938M|SYNE1_uc003qot.3_Missense_Mutation_p.T8366M|SYNE1_uc003qou.3_Missense_Mutation_p.T8414M|SYNE1_uc003qop.3_Missense_Mutation_p.T599M|SYNE1_uc011eez.1_Missense_Mutation_p.T616M|SYNE1_uc003qoq.3_Missense_Mutation_p.T616M|SYNE1_uc003qor.3_Missense_Mutation_p.T1337M	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8414	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCACCAGCCGTTTGGGTTTC	0.478000										HNSCC(10;0.0054)			28	60					0	0	0	0
TIAM2	26230	broad.mit.edu	37	6	155458488	155458488	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:155458488A>G	uc003qqb.2	+	7	2645	c.1372A>G	c.(1372-1374)ATT>GTT	p.I458V	TIAM2_uc003qqe.2_Missense_Mutation_p.I458V|TIAM2_uc010kjj.2_5'UTR	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	458					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CCGGCAGAACATTTATGAGAA	0.507000													38	76					0	0	0	0
PLG	5340	broad.mit.edu	37	6	161159606	161159606	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:161159606C>T	uc003qtm.3	+	15	1902	c.1839C>T	c.(1837-1839)TCC>TCT	p.S613S		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	613	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CCTTGATATCCCCAGAGTGGG	0.373000													30	60					0	0	0	0
SDK1	221935	broad.mit.edu	37	7	4185403	4185403	+	Silent	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:4185403C>A	uc003smx.2	+	29	4417	c.4278C>A	c.(4276-4278)ACC>ACA	p.T1426T	SDK1_uc010kso.2_Silent_p.T702T|SDK1_uc003smy.2_5'UTR	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1426	Fibronectin type-III 8.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACACCTTCACCACCGTGGAGG	0.657000													9	60					1.76689e-08	7.18157e-08	1	0
SCIN	85477	broad.mit.edu	37	7	12675756	12675756	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:12675756T>C	uc003ssn.3	+	10	1616	c.1406T>C	c.(1405-1407)GTG>GCG	p.V469A	SCIN_uc010ktt.2_RNA|SCIN_uc003sso.3_Missense_Mutation_p.V222A	NM_001112706	NP_001106177	Q9Y6U3	ADSV_HUMAN	scinderin isoform 1	469	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		GGACAGGCTGTGCAGGTTGGG	0.468000													4	8					0	0	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31124410	31124410	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:31124410T>A	uc003tca.1	+	8	720	c.497T>A	c.(496-498)GTC>GAC	p.V166D	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.V145D|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.V166D|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.V166D|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.V166D|ADCYAP1R1_uc003tcf.1_5'Flank	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	166	Helical; Name=1; (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity	p.V166fs*25(1)		ovary(1)	1						ACATCCCTCGTCACCCTCACC	0.557000													30	79					0	0	0	0
GRB10	2887	broad.mit.edu	37	7	50682481	50682481	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:50682481C>A	uc003tpi.2	-	9	1112	c.1081G>T	c.(1081-1083)GGG>TGG	p.G361W	GRB10_uc003tph.3_Missense_Mutation_p.G303W|GRB10_uc003tpj.2_Missense_Mutation_p.G315W|GRB10_uc003tpk.2_Missense_Mutation_p.G361W|GRB10_uc010kzb.2_Missense_Mutation_p.G303W|GRB10_uc003tpl.2_Missense_Mutation_p.G355W|GRB10_uc003tpm.2_Missense_Mutation_p.G303W|GRB10_uc003tpn.2_Missense_Mutation_p.G303W	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	361	PH.				insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					ATGCAGAGCCCGTGGTCTGTA	0.587000									Russell-Silver_syndrome				31	68					8.16721e-17	3.54851e-16	1	0
EGFR	1956	broad.mit.edu	37	7	55220295	55220295	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:55220295A>T	uc003tqk.2	+	6	931	c.685A>T	c.(685-687)AGT>TGT	p.S229C	EGFR_uc003tqh.2_Missense_Mutation_p.S229C|EGFR_uc003tqi.2_Missense_Mutation_p.S229C|EGFR_uc003tqj.2_Missense_Mutation_p.S229C|EGFR_uc010kzg.1_Missense_Mutation_p.S184C|EGFR_uc011kco.1_Missense_Mutation_p.S176C|EGFR_uc003tql.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	229	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAAGTCCCCCAGTGACTGCTG	0.617000		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			56	85					0	0	0	0
GRM3	2913	broad.mit.edu	37	7	86394583	86394583	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:86394583T>C	uc003uid.2	+	2	1221	c.122T>C	c.(121-123)TTA>TCA	p.L41S	GRM3_uc010lef.2_Missense_Mutation_p.L39S|GRM3_uc010leg.2_Intron|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	41	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GACCTTGTTTTAGGGGGCCTG	0.413000													23	48					0	0	0	0
PON2	5445	broad.mit.edu	37	7	95039308	95039308	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:95039308G>A	uc003unv.2	-	6	721	c.600C>T	c.(598-600)CAC>CAT	p.H200H	PON2_uc003unu.2_Silent_p.H188H|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_Silent_p.H113H	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	200					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			CATTTGCCCAGTGTAAGTTCA	0.373000													23	54					0	0	0	0
TMEM168	64418	broad.mit.edu	37	7	112407741	112407741	+	Silent	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:112407741G>C	uc003vgn.2	-	5	1997	c.1605C>G	c.(1603-1605)TCC>TCG	p.S535S	TMEM168_uc010lju.2_Silent_p.S535S|TMEM168_uc011kmr.1_Silent_p.S151S	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	535						integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						GGGAACAAAAGGAACCATTCT	0.403000													17	41					0	0	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518983	113518983	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:113518983T>C	uc010ljy.1	-	4	2195	c.2164A>G	c.(2164-2166)ACT>GCT	p.T722A		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	722					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						GCTTTCTCAGTAATGCCATGA	0.388000													3	139					0	0	0	0
DPP6	1804	broad.mit.edu	37	7	154172062	154172062	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:154172062G>C	uc003wlk.2	+	3	526	c.397G>C	c.(397-399)GTA>CTA	p.V133L	DPP6_uc003wli.2_Missense_Mutation_p.V69L|DPP6_uc003wlj.2_Missense_Mutation_p.V133L|DPP6_uc010lqh.1_Missense_Mutation_p.V71L|DPP6_uc003wlm.2_Missense_Mutation_p.V71L|DPP6_uc011kvq.1_Missense_Mutation_p.V71L	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	133	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GAAGGTCACTGTAGAAGATCT	0.403000													39	44					0	0	0	0
NCAPG2	54892	broad.mit.edu	37	7	158449250	158449250	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:158449250C>T	uc003wnv.1	-	18	2353	c.2208G>A	c.(2206-2208)CAG>CAA	p.Q736Q	NCAPG2_uc010lqu.1_Silent_p.Q528Q|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Silent_p.Q736Q|NCAPG2_uc011kwe.1_Silent_p.Q736Q|NCAPG2_uc011kwc.1_Silent_p.Q237Q|NCAPG2_uc011kwd.1_Silent_p.Q179Q	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	736					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		CTACCTTGGCCTGGGCATGCT	0.468000													7	55					0	0	0	0
MTUS1	57509	broad.mit.edu	37	8	17611496	17611496	+	Silent	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:17611496G>C	uc003wxv.2	-	2	2295	c.1821C>G	c.(1819-1821)GCC>GCG	p.A607A	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Silent_p.A607A|MTUS1_uc010lsz.2_Silent_p.A607A	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	607						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		TCGATTTCACGGCAGATGTTG	0.433000													5	167					0	0	0	0
Unknown	0	broad.mit.edu	37	8	71015826	71015826	+	IGR	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:71015826A>G								PRDM14 (32264 upstream) : NCOA2 (8441 downstream)																							CTTTGAAGCCACAGTAATACT	0.338000													4	4					0	0	0	0
JPH1	56704	broad.mit.edu	37	8	75227563	75227563	+	Silent	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:75227563G>C	uc003yae.2	-	2	712	c.672C>G	c.(670-672)CGC>CGG	p.R224R	JPH1_uc003yaf.2_Silent_p.R224R|JPH1_uc003yag.1_Silent_p.R88R	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	224	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			ATTCGGACTTGCGAAGTTTCA	0.582000													9	104					0	0	0	0
RSPO2	340419	broad.mit.edu	37	8	108970481	108970481	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:108970481C>A	uc003yms.2	-	5	1101	c.443G>T	c.(442-444)GGT>GTT	p.G148V	RSPO2_uc003ymq.2_Missense_Mutation_p.G81V|RSPO2_uc003ymr.2_Missense_Mutation_p.G84V	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	148	TSP type-1.				Wnt receptor signaling pathway	extracellular region	heparin binding	p.G148S(1)		skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			GCTCCAATGACCAACTTCACA	0.368000													20	41					1.50039e-11	6.27549e-11	1	0
CSMD3	114788	broad.mit.edu	37	8	113326782	113326782	+	Silent	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:113326782A>T	uc003ynu.2	-	48	7584	c.7425T>A	c.(7423-7425)CCT>CCA	p.P2475P	CSMD3_uc003yns.2_Silent_p.P1677P|CSMD3_uc003ynt.2_Silent_p.P2435P|CSMD3_uc011lhx.1_Silent_p.P2371P|CSMD3_uc003ynw.1_Silent_p.P186P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2475	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGTAACTGTCAGGATATCCAG	0.388000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	23					0	0	0	0
FAM83H	286077	broad.mit.edu	37	8	144808544	144808544	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:144808544G>A	uc003yzk.2	-	5	3156	c.3087C>T	c.(3085-3087)AAC>AAT	p.N1029N	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	1029					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TGTACAAGGCGTTGGCCGTGG	0.692000													5	10					0	0	0	0
PARP10	84875	broad.mit.edu	37	8	145060329	145060329	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:145060329C>T	uc003zal.3	-	2	183	c.75G>A	c.(73-75)GAG>GAA	p.E25E	PARP10_uc003zak.3_5'Flank|PARP10_uc011lku.1_Silent_p.E37E|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Silent_p.E25E|PARP10_uc010mfn.1_Silent_p.E25E|PARP10_uc010mfo.1_Intron	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	25						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GAGTGAGCAGCTCGTCGGGCA	0.657000													12	63					0	0	0	0
LRRC14	9684	broad.mit.edu	37	8	145746352	145746352	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr8:145746352G>A	uc003zdk.1	+	4	1118	c.972G>A	c.(970-972)GAG>GAA	p.E324E	LRRC14_uc003zdl.1_Silent_p.E324E|LRRC14_uc003zdo.2_5'Flank	NM_014665	NP_055480	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	324	LRR 2.										0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGCTGCCTGAGGACCTACGCT	0.637000													18	159					0	0	0	0
SMARCA2	6595	broad.mit.edu	37	9	2076291	2076291	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:2076291C>A	uc003zhc.2	+	13	2097	c.1998C>A	c.(1996-1998)AGC>AGA	p.S666R	SMARCA2_uc003zhd.2_Missense_Mutation_p.S666R|SMARCA2_uc010mha.2_Missense_Mutation_p.S657R	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	666					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ATCCAAATAGCGAAGAAGTTT	0.388000													27	51					1.88708e-17	8.23455e-17	1	0
TEK	7010	broad.mit.edu	37	9	27218815	27218815	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:27218815G>T	uc003zqi.3	+	20	3545	c.3103G>T	c.(3103-3105)GGA>TGA	p.G1035*	TEK_uc011lno.1_Nonsense_Mutation_p.G992*|TEK_uc011lnp.1_Nonsense_Mutation_p.G887*	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	1035	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TGTTAGCTTAGGTGAGTATCT	0.463000													13	32					6.72482e-11	2.78956e-10	1	0
CCIN	881	broad.mit.edu	37	9	36170744	36170744	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:36170744C>T	uc003zzb.3	+	1	1356	c.1245C>T	c.(1243-1245)GGC>GGT	p.G415G		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	415	Kelch 3.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			CCATGGATGGCACCGCCGTGA	0.542000													29	43					0	0	0	0
TLE4	7091	broad.mit.edu	37	9	82320843	82320843	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:82320843G>C	uc004ald.2	+	10	1597	c.748G>C	c.(748-750)GAC>CAC	p.D250H	TLE4_uc004alc.2_Missense_Mutation_p.D257H|TLE4_uc010mpr.2_Missense_Mutation_p.D136H|TLE4_uc004ale.2_5'UTR|TLE4_uc011lsq.1_Missense_Mutation_p.D225H|TLE4_uc010mps.2_Intron|TLE4_uc004alf.2_Missense_Mutation_p.D196H	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						CTTGGTGGTTGACGTTTCCAA	0.398000													6	80					0	0	0	0
GRIN3A	116443	broad.mit.edu	37	9	104449192	104449192	+	Silent	SNP	G	A	A	rs144389302		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:104449192G>A	uc004bbp.1	-	2	1591	c.990C>T	c.(988-990)TGC>TGT	p.C330C	GRIN3A_uc004bbq.1_Silent_p.C330C	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	330	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TTTCCATGTCGCAGCCAAACA	0.527000													11	26					0	0	0	0
SETX	23064	broad.mit.edu	37	9	135204921	135204921	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:135204921G>A	uc004cbk.2	-	10	2247	c.2064C>T	c.(2062-2064)TGC>TGT	p.C688C	SETX_uc004cbj.2_Silent_p.C307C|SETX_uc010mzt.2_Silent_p.C307C	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	688					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TCTGCTTTAAGCATGACCCAG	0.328000													25	43					0	0	0	0
RALGDS	5900	broad.mit.edu	37	9	136037789	136037789	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:136037789C>T	uc011mcw.1	-	2	292	c.11G>A	c.(10-12)CGG>CAG	p.R4Q	GBGT1_uc004ccx.2_5'UTR|GBGT1_uc010nab.2_Missense_Mutation_p.R4Q|GBGT1_uc011mcx.1_Missense_Mutation_p.R4Q|GBGT1_uc004ccw.2_Missense_Mutation_p.R4Q|GBGT1_uc010nac.1_5'UTR|GBGT1_uc004ccy.1_Missense_Mutation_p.R4Q	NM_001042368	NP_001035827	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	Error:Variant_position_missing_in_Q12967_after_alignment					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		GGCCAGTCTCCGGCGATGCAT	0.607000			T	CIITA	PMBL|Hodgkin Lymphona|								5	15					0	0	0	0
SURF4	6836	broad.mit.edu	37	9	136234223	136234223	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:136234223G>A	uc004cdj.2	-	2	277	c.147C>T	c.(145-147)AGC>AGT	p.S49S	SURF4_uc011mda.1_Silent_p.S40S|SURF4_uc010nal.2_Silent_p.S81S|SURF4_uc011mdb.1_Silent_p.S6S|SURF4_uc011mdc.1_Silent_p.S6S|SURF4_uc011mdd.1_Silent_p.S49S	NM_033161	NP_149351	O15260	SURF4_HUMAN	surfeit 4	49						endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.32e-07)|Epithelial(140;4.56e-06)|all cancers(34;4.25e-05)		CGCGCTGCTCGCTCCACTGGA	0.597000													22	25					0	0	0	0
FCN1	2219	broad.mit.edu	37	9	137809628	137809628	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:137809628C>T	uc004cfi.2	-	1	182	c.90G>A	c.(88-90)GCG>GCA	p.A30A		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	30					opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		GACATGTGTCCGCAGCCTGGG	0.572000													23	42					0	0	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071340	141071340	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr9:141071340G>A	uc004com.2	+	4	1004	c.743G>A	c.(742-744)CGC>CAC	p.R248H	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TTCCAGGGTCGCATGCCCATG	0.542000													6	95					0	0	0	0
MAGEB18	286514	broad.mit.edu	37	X	26157205	26157205	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chrX:26157205G>A	uc004dbq.1	+	2	290	c.103G>A	c.(103-105)GGA>AGA	p.G35R		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	35							protein binding			central_nervous_system(1)	1						TGTGGCAGAAGGAGAGTCACC	0.587000													5	15					0	0	0	0
CASK	8573	broad.mit.edu	37	X	41390289	41390289	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chrX:41390289G>A	uc004dfl.3	-	25	2522	c.2476C>T	c.(2476-2478)CTG>TTG	p.L826L	CASK_uc004dfj.3_Silent_p.L371L|CASK_uc004dfk.3_Silent_p.L646L|CASK_uc004dfm.3_Silent_p.L803L|CASK_uc004dfn.3_Silent_p.L802L	NM_003688	NP_003679	O14936	CSKP_HUMAN	calcium/calmodulin-dependent serine protein	831	Guanylate kinase-like.				cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			ovary(3)|lung(2)|stomach(1)	6						ATTGCAATCAGCCCCTGCTCG	0.512000													28	12					0	0	0	0
TCEAL2	140597	broad.mit.edu	37	X	101382277	101382277	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chrX:101382277G>T	uc004eip.2	+	3	694	c.475G>T	c.(475-477)GAT>TAT	p.D159Y		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						AGCCATACATGATATGAATTT	0.428000													11	58					1.33987e-11	5.62746e-11	1	0
TEX13A	56157	broad.mit.edu	37	X	104464103	104464103	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chrX:104464103G>T	uc004ema.2	-	5	885	c.773C>A	c.(772-774)ACC>AAC	p.T258N	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Missense_Mutation_p.P259T	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	258						intracellular	zinc ion binding			ovary(2)	2						CCCCCAATAGGTGTACTTTTC	0.562000													15	5					1.15088e-07	4.58531e-07	1	0
GPR119	139760	broad.mit.edu	37	X	129518927	129518927	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chrX:129518927G>T	uc011muv.1	-	1	495	c.495C>A	c.(493-495)TTC>TTA	p.F165L		NM_178471	NP_848566	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	165	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	lipid binding			ovary(2)	2						GGGTCAGCACGAAGTGAGGGT	0.532000													21	13					2.54575e-18	1.12549e-17	1	0
FLNA	2316	broad.mit.edu	37	X	153588903	153588903	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chrX:153588903C>T	uc004fkk.2	-	22	3509	c.3260G>A	c.(3259-3261)CGC>CAC	p.R1087H	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Missense_Mutation_p.R1087H	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1087	Filamin 9.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GATGGTGAAGCGGGCGGGGGA	0.692000											OREG0003593	type=REGULATORY REGION|Gene=FLNA|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	5	14					0	0	0	0
TSPY1	7258	broad.mit.edu	37	Y	9305927	9305927	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chrY:9305927C>G	uc004frw.3	+	3	629	c.583C>G	c.(583-585)CCT>GCT	p.P195A	TSPY1_uc004frx.3_Missense_Mutation_p.P195A|TSPY1_uc010nwp.1_Intron	NM_003308	NP_003299	Q01534	TSPY1_HUMAN	testis specific protein, Y-linked 1	195			P -> R.		cell differentiation|cell proliferation|gonadal mesoderm development|nucleosome assembly|spermatogenesis	cytoplasm|nucleus	identical protein binding				0						AGAGAAGCATCCTGTTCATCT	0.443000													20	139					0	0	0	0
PLEKHN1	84069	broad.mit.edu	37	1	906364	906364	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:906364G>A	uc001ace.2	+	5	745	c.710G>A	c.(709-711)CGC>CAC	p.R237H	PLEKHN1_uc001acd.2_Missense_Mutation_p.R197H|PLEKHN1_uc001acf.2_Missense_Mutation_p.R197H	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	237											0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		GGGCCGCGGCGCTGCCACTCG	0.736000													5	10					0	0	0	0
TARDBP	23435	broad.mit.edu	37	1	11082376	11082376	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:11082376G>A	uc001art.2	+	6	1044	c.910G>A	c.(910-912)GGT>AGT	p.G304S	TARDBP_uc010oap.1_Missense_Mutation_p.G188S	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	304	Gly-rich.				3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		AAACAATCAAGGTAGTAATAT	0.498000													6	60					0	0	0	0
HIVEP3	59269	broad.mit.edu	37	1	41978886	41978886	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:41978886T>A	uc001cgz.3	-	8	7219	c.6006A>T	c.(6004-6006)GAA>GAT	p.E2002D	HIVEP3_uc001cha.3_Missense_Mutation_p.E2002D|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	2002					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGGCCTGTGGTTCTCGGGCCG	0.632000													30	44					0	0	0	0
HIVEP3	59269	broad.mit.edu	37	1	42050284	42050284	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:42050284G>A	uc001cgz.3	-	4	1398	c.185C>T	c.(184-186)CCC>CTC	p.P62L	HIVEP3_uc001cha.3_Missense_Mutation_p.P62L|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	62					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AACTGATGAGGGGCCCGGGAA	0.622000													46	76					0	0	0	0
C8B	732	broad.mit.edu	37	1	57422503	57422503	+	Silent	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:57422503A>G	uc001cyp.2	-	3	397	c.330T>C	c.(328-330)TGT>TGC	p.C110C	C8B_uc010oon.1_Silent_p.C48C|C8B_uc010ooo.1_Silent_p.C58C	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	110	TSP type-1 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TGTTGGTAACACAGTCTTCGA	0.498000													28	222					0	0	0	0
LRRC40	55631	broad.mit.edu	37	1	70616847	70616847	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:70616847A>T	uc001der.1	-	13	1533	c.1481T>A	c.(1480-1482)CTG>CAG	p.L494Q		NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	494	LRR 16.									ovary(1)	1						CAGTCTTACCAGTGATTCCAT	0.284000													10	19					0	0	0	0
C1orf173	127254	broad.mit.edu	37	1	75038758	75038758	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:75038758T>C	uc001dgg.2	-	14	2855	c.2636A>G	c.(2635-2637)CAA>CGA	p.Q879R		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	879	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CATCAAGGCTTGCTTTTCAGG	0.527000													72	156					0	0	0	0
HFM1	164045	broad.mit.edu	37	1	91859650	91859650	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:91859650C>G	uc001doa.3	-	4	594	c.494G>C	c.(493-495)AGA>ACA	p.R165T	HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Missense_Mutation_p.R165T	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	165							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		taataattaCCTTTTCCGGAA	0.284000													9	10					0	0	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94669495	94669495	+	Silent	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:94669495A>G	uc001dqj.3	-	8	1122	c.753T>C	c.(751-753)ATT>ATC	p.I251I	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Silent_p.I251I	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	251					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		CCTGAATTCCAATGTTAGTTC	0.338000													7	26					0	0	0	0
LPPR4	9890	broad.mit.edu	37	1	99772018	99772018	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:99772018A>C	uc001dse.2	+	7	1850	c.1744A>C	c.(1744-1746)ATG>CTG	p.M582L	LPPR4_uc010oue.1_Missense_Mutation_p.M524L	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	582							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AGTCATAGCCATGTCCAAGCA	0.537000													23	47					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103400075	103400075	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:103400075C>T	uc001dul.2	-	46	3848	c.3530G>A	c.(3529-3531)GGG>GAG	p.G1177E	COL11A1_uc001duk.2_Missense_Mutation_p.G373E|COL11A1_uc001dum.2_Missense_Mutation_p.G1189E|COL11A1_uc001dun.2_Missense_Mutation_p.G1138E|COL11A1_uc009weh.2_Missense_Mutation_p.G1061E	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1177	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCCAAACATCCCCTGCTGTCC	0.448000													16	49					0	0	0	0
SV2A	9900	broad.mit.edu	37	1	149876628	149876628	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:149876628G>A	uc001etg.2	-	13	2658	c.2167C>T	c.(2167-2169)CTT>TTT	p.L723F	SV2A_uc009wlk.2_Missense_Mutation_p.L175F	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	723	Helical; (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CCAAGGGCAAGGGCAGCTGAG	0.602000													7	27					0	0	0	0
ARNT	405	broad.mit.edu	37	1	150808901	150808901	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:150808901C>A	uc001evr.1	-	7	698	c.555G>T	c.(553-555)AGG>AGT	p.R185S	ARNT_uc001evs.1_Missense_Mutation_p.R170S|ARNT_uc009wmb.1_Missense_Mutation_p.R176S|ARNT_uc009wmc.1_Missense_Mutation_p.R185S|ARNT_uc009wmd.1_Missense_Mutation_p.R170S|ARNT_uc009wme.1_Missense_Mutation_p.R185S|ARNT_uc010pcl.1_Missense_Mutation_p.R169S	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	185	PAS 1.				positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			CATACACCACCCTGCCTGTCT	0.453000			T	ETV6	AML								11	40					3.86212e-05	0.000142943	1	0
LASS2	29956	broad.mit.edu	37	1	150941485	150941485	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:150941485G>A	uc001evy.2	-	2	469	c.82C>T	c.(82-84)CGA>TGA	p.R28*	LASS2_uc001evz.2_Nonsense_Mutation_p.R28*|LASS2_uc009wmh.2_Intron	NM_181746	NP_859530	Q96G23	CERS2_HUMAN	LAG1 longevity assurance 2	28	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0	all_lung(15;8.07e-35)|Lung NSC(24;7.93e-31)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CGTCCATCTCGGTCTTCTAGA	0.527000													8	47					0	0	0	0
CD1D	912	broad.mit.edu	37	1	158152775	158152775	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:158152775A>T	uc001frr.2	+	5	1214	c.715A>T	c.(715-717)ATG>TTG	p.M239L	CD1D_uc009wss.2_Intron	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	239	Ig-like.|Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					GGTGAAGTGGATGCGGGGTGA	0.627000													10	133					0	0	0	0
CD84	8832	broad.mit.edu	37	1	160520798	160520798	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:160520798G>C	uc001fwh.3	-	6	863	c.839C>G	c.(838-840)ACA>AGA	p.T280R	CD84_uc001fwf.3_Missense_Mutation_p.T263R|CD84_uc001fwg.3_Missense_Mutation_p.T274R|CD84_uc009wtn.2_Intron|CD84_uc001fwi.3_Missense_Mutation_p.T149R	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	280	Cytoplasmic (Potential).|ITSM motif 1.				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CATGATATATGTGTATATGGT	0.383000													20	318					0	0	0	0
RXRG	6258	broad.mit.edu	37	1	165398200	165398200	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:165398200G>A	uc001gda.2	-	2	353	c.53C>T	c.(52-54)TCC>TTC	p.S18F		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	18	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	GTGGCCAGGGGAGCCTGTAAG	0.567000													18	22					0	0	0	0
LGR6	59352	broad.mit.edu	37	1	202287594	202287594	+	Silent	SNP	G	A	A	rs140182035		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:202287594G>A	uc001gxu.2	+	18	2163	c.2163G>A	c.(2161-2163)GCG>GCA	p.A721A	LGR6_uc001gxv.2_Silent_p.A669A|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Silent_p.A582A	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	721	Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						TGCCCTACGCGCCACCTGAGG	0.667000													10	33					0	0	0	0
PPFIA4	8497	broad.mit.edu	37	1	203008176	203008176	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:203008176C>T	uc009xaj.2	+	6	481	c.481C>T	c.(481-483)CTG>TTG	p.L161L				O75335	LIPA4_HUMAN	SubName: Full=Liprin alpha4;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						GGGGGACCGCCTGGGTCCCCC	0.622000											OREG0014109	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	11					0	0	0	0
TMCC2	9911	broad.mit.edu	37	1	205238351	205238351	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:205238351C>T	uc001hbz.1	+	4	1465	c.1021C>T	c.(1021-1023)CAG>TAG	p.Q341*	TMCC2_uc010prf.1_Nonsense_Mutation_p.Q263*|TMCC2_uc001hca.2_Nonsense_Mutation_p.Q116*|TMCC2_uc001hcb.1_Nonsense_Mutation_p.Q101*|TMCC2_uc001hcc.1_5'UTR|TMCC2_uc001hcd.2_Nonsense_Mutation_p.Q108*	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	341	Potential.					integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GAAGAAGAACCAGAAGTCAGC	0.592000													4	45					0	0	0	0
IL19	29949	broad.mit.edu	37	1	206972269	206972269	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:206972269A>T	uc001heo.2	+	1	55	c.30A>T	c.(28-30)AGA>AGT	p.R10S		NM_153758	NP_715639	Q9UHD0	IL19_HUMAN	interleukin 19 isoform 1 precursor	Error:Variant_position_missing_in_Q9UHD0_after_alignment					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(75;0.211)			TTCCGCACAGATCTGCGTGTT	0.478000													34	80					0	0	0	0
LYST	1130	broad.mit.edu	37	1	235904812	235904812	+	Silent	SNP	G	A	A	rs141534829	byFrequency	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:235904812G>A	uc001hxj.2	-	31	8443	c.8268C>T	c.(8266-8268)CAC>CAT	p.H2756H	LYST_uc009xga.1_Silent_p.H392H	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2756					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CTTGTGCAGCGTGGGCTGGCG	0.438000									Chediak-Higashi_syndrome				6	94					0	0	0	0
HEATR1	55127	broad.mit.edu	37	1	236714247	236714247	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:236714247C>T	uc001hyd.1	-	45	6515	c.6390G>A	c.(6388-6390)CAG>CAA	p.Q2130Q	HEATR1_uc009xgh.1_Silent_p.Q1292Q	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	2130	HEAT.				rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTTCCAGTTGCTGAATAGTCT	0.368000													30	38					0	0	0	0
OR2L3	391192	broad.mit.edu	37	1	248224826	248224826	+	Silent	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:248224826T>C	uc001idx.1	+	1	843	c.843T>C	c.(841-843)ACT>ACC	p.T281T	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	281	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CCACCCTCACTCCAATGCTCA	0.493000													4	109					0	0	0	0
MLLT10	8028	broad.mit.edu	37	10	22021981	22021981	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr10:22021981C>T	uc001iqs.2	+	19	2768	c.2420C>T	c.(2419-2421)CCG>CTG	p.P807L	MLLT10_uc001iqt.2_Missense_Mutation_p.P791L|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.P791L|MLLT10_uc001ira.2_Missense_Mutation_p.P248L|MLLT10_uc001irb.2_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	807					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						AATCCTAGTCCGTCTCATCAA	0.338000			T	MLL|PICALM|CDK6	AL								7	67					0	0	0	0
RASSF4	83937	broad.mit.edu	37	10	45484754	45484754	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr10:45484754G>A	uc001jbo.2	+	7	698	c.564G>A	c.(562-564)GTG>GTA	p.V188V	RASSF4_uc001jbp.2_Silent_p.V219V|RASSF4_uc009xmn.2_Silent_p.V118V|RASSF4_uc001jbq.2_Silent_p.V85V|RASSF4_uc001jbt.2_Silent_p.V145V	NM_032023	NP_114412	Q9H2L5	RASF4_HUMAN	Ras association domain family 4	188	Ras-associating.				cell cycle|signal transduction		protein binding			large_intestine(1)	1						ATGGATCCGTGACCAATGTGA	0.562000													11	31					0	0	0	0
ANXA2P3	305	broad.mit.edu	37	10	66585883	66585883	+	RNA	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr10:66585883G>A	uc009xpm.1	+	1		c.599G>A				NR_001446				Human lipocortin (LIP) 2 pseudogene mRNA, complete cds-like region.												0						TGGCTCTGTCGTTGATTATGA	0.458000													11	15					0	0	0	0
MYPN	84665	broad.mit.edu	37	10	69925475	69925475	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr10:69925475G>A	uc001jnm.3	+	10	1685	c.1500G>A	c.(1498-1500)TTG>TTA	p.L500L	MYPN_uc001jnl.1_Silent_p.L500L|MYPN_uc001jnn.3_Silent_p.L225L|MYPN_uc001jno.3_Silent_p.L500L|MYPN_uc009xps.2_Silent_p.L500L|MYPN_uc009xpt.2_Silent_p.L500L|MYPN_uc010qit.1_Silent_p.L206L|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	500	Interaction with CARP.|Ig-like 2.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						TTTGCACCTTGGTCATTGCTG	0.413000													5	44					0	0	0	0
RUFY2	55680	broad.mit.edu	37	10	70139220	70139220	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr10:70139220G>C	uc001job.2	-	12	1598	c.1271C>G	c.(1270-1272)ACC>AGC	p.T424S	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joa.2_5'Flank|RUFY2_uc001joc.2_Missense_Mutation_p.T355S|RUFY2_uc010qiw.1_Missense_Mutation_p.T331S|RUFY2_uc001jod.1_Missense_Mutation_p.T389S	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	438	Potential.					nucleus	metal ion binding			ovary(1)	1						AATTTTATTGGTTTTTTCTTC	0.274000													8	64					0	0	0	0
TTC18	118491	broad.mit.edu	37	10	75059376	75059376	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr10:75059376C>T	uc009xrc.2	-	14	1635	c.1514G>A	c.(1513-1515)GGA>GAA	p.G505E	TTC18_uc001jty.2_Missense_Mutation_p.G505E|TTC18_uc009xrd.1_Missense_Mutation_p.G319E|TTC18_uc001jtx.2_5'Flank	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	505							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					CTGAGCTCCTCCTGTCCGACG	0.353000													14	27					0	0	0	0
BTRC	8945	broad.mit.edu	37	10	103291078	103291078	+	Silent	SNP	A	T	T	rs146435684		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr10:103291078A>T	uc001kta.2	+	7	941	c.828A>T	c.(826-828)ATA>ATT	p.I276I	BTRC_uc001ktb.2_Silent_p.I240I|BTRC_uc001ktc.2_Silent_p.I250I	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	276					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		CTAAAATTATACAAGACATTG	0.368000													24	50					0	0	0	0
POLL	27343	broad.mit.edu	37	10	103343337	103343337	+	Silent	SNP	G	A	A	rs148400497	byFrequency	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr10:103343337G>A	uc001ktg.1	-	5	1759	c.993C>T	c.(991-993)AGC>AGT	p.S331S	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_5'Flank|POLL_uc001kte.1_Silent_p.S23S|POLL_uc001kth.1_Silent_p.S56S|POLL_uc001kti.1_Silent_p.S331S|POLL_uc001ktj.1_Silent_p.S331S|POLL_uc001ktf.2_Silent_p.S239S|POLL_uc001ktk.1_Silent_p.S70S|POLL_uc010qqa.1_Silent_p.S70S|POLL_uc010qqb.1_RNA|POLL_uc001ktm.2_Silent_p.S331S|POLL_uc001ktl.2_Silent_p.S243S|POLL_uc010qqc.1_Silent_p.S23S|POLL_uc010qqd.1_3'UTR	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	331					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		AGACAGGCACGCTCTCACTGA	0.562000								DNA_polymerases_(catalytic_subunits)					15	29					0	0	0	0
C10orf81	79949	broad.mit.edu	37	10	115534710	115534710	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr10:115534710C>A	uc001lat.1	+	9	1449	c.887C>A	c.(886-888)TCC>TAC	p.S296Y	C10orf81_uc001lar.1_Missense_Mutation_p.S302Y|C10orf81_uc009xyc.1_Missense_Mutation_p.S214Y|C10orf81_uc001las.1_Missense_Mutation_p.S214Y|C10orf81_uc001lau.1_Missense_Mutation_p.S116Y	NM_024889	NP_079165	Q5SXH7	CJ081_HUMAN	hypothetical protein LOC79949	296										central_nervous_system(1)	1		Colorectal(252;0.175)		Epithelial(162;0.0181)|all cancers(201;0.0204)		TGGTGTCTTTCCCCTGCCGAT	0.488000													12	28					0.00010058	0.00037084	1	0
GRK5	2869	broad.mit.edu	37	10	121182709	121182709	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr10:121182709A>C	uc001led.2	+	5	604	c.371A>C	c.(370-372)GAC>GCC	p.D124A	GRK5_uc009xzh.2_Missense_Mutation_p.D19A|GRK5_uc010qta.1_Missense_Mutation_p.D19A	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	124	N-terminal.|RGS.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		GTTGGCCAAGACCTGGTCTCC	0.582000													51	152					0	0	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122280508	122280508	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr10:122280508T>A	uc001lev.1	+	5	698	c.346T>A	c.(346-348)TGC>AGC	p.C116S	PPAPDC1A_uc010qtd.1_Missense_Mutation_p.C116S|PPAPDC1A_uc009xzl.1_Intron|PPAPDC1A_uc001lew.1_Intron|PPAPDC1A_uc001lex.1_Intron|PPAPDC1A_uc001ley.1_Intron	NM_001030059	NP_001025230	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain	116					phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)	1		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		CTTTTACCGCTGCTTTCCAGA	0.512000													21	57					0	0	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	A	A	rs121913233		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr11:533874T>A	uc001lpv.2	-	3	370	c.182A>T	c.(181-183)CAG>CTG	p.Q61L	HRAS_uc010qvw.1_Missense_Mutation_p.Q61L|HRAS_uc010qvx.1_Missense_Mutation_p.Q61L|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	61	GTP.		Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).	Q->V: Strongly increased transformation of cultured cell lines.|Q->I: Moderately increased transformation of cultured cell lines.	activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(112)|p.Q61L(93)|p.Q61K(39)|p.Q61H(20)|p.Q61P(3)|p.Q61Q(1)|p.Q61E(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(NCIH1915_LUNG)|Q61L(KYSE30_OESOPHAGUS)	6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			22	55					0	0	0	0
EPS8L2	64787	broad.mit.edu	37	11	720677	720677	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr11:720677G>A	uc001lqt.2	+	6	655	c.408G>A	c.(406-408)CTG>CTA	p.L136L	EPS8L2_uc010qwj.1_Silent_p.L152L|EPS8L2_uc001lqu.2_Silent_p.L136L|EPS8L2_uc010qwk.1_Silent_p.L152L|EPS8L2_uc001lqv.2_Silent_p.L91L|EPS8L2_uc001lqw.2_5'Flank|EPS8L2_uc001lqx.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	136	PID.					cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CGTCTGTGCTGCTGCTCGTGT	0.582000													5	7					0	0	0	0
EIF3M	10480	broad.mit.edu	37	11	32615476	32615476	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr11:32615476G>T	uc001mtu.2	+	6	641	c.598G>T	c.(598-600)GCT>TCT	p.A200S	EIF3M_uc010ref.1_Missense_Mutation_p.A68S	NM_006360	NP_006351	Q7L2H7	EIF3M_HUMAN	eukaryotic translation initiation factor 3,	200						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)|breast(1)|skin(1)	3	Breast(20;0.109)					TGCTTCCCAGGCTCGAGTTGA	0.393000													13	25					0.000219431	0.000805972	1	0
C11orf48	79081	broad.mit.edu	37	11	62439187	62439187	+	5'Flank	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr11:62439187C>T	uc001nue.2	-						C11orf48_uc001nuf.2_5'UTR|C11orf48_uc010rmd.1_5'UTR|C11orf83_uc001nui.3_5'UTR	NM_024099	NP_077004	Q9BQE6	CK048_HUMAN	hypothetical protein LOC79081												0						GGGGAGCTCCCGTGGGCGCTC	0.657000													9	40					0	0	0	0
C11orf84	144097	broad.mit.edu	37	11	63585325	63585325	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr11:63585325C>A	uc001nxt.2	+	2	412	c.176C>A	c.(175-177)GCA>GAA	p.A59E		NM_138471	NP_612480	Q9BUA3	CK084_HUMAN	hypothetical protein LOC144097	59											0						CCGCTAGAGGCAGGCAGTGAT	0.637000													4	12					2.56e-06	9.81333e-06	1	0
KRTAP5-10	387273	broad.mit.edu	37	11	71277066	71277066	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr11:71277066T>C	uc001oqt.1	+	1	458	c.433T>C	c.(433-435)TGT>CGT	p.C145R		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	145	3.|7 X 4 AA repeats of C-C-X-P.					keratin filament				skin(1)	1						GTGCAATTGCTGTAAGCCctg	0.348000													47	102					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92532912	92532912	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr11:92532912C>T	uc001pdj.3	+	9	6750	c.6733C>T	c.(6733-6735)CCT>TCT	p.P2245S		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2245	Cadherin 20.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGTTGTTAGCCCTTTGGATTA	0.438000										TCGA Ovarian(4;0.039)			7	16					0	0	0	0
HEPHL1	341208	broad.mit.edu	37	11	93806191	93806191	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr11:93806191T>G	uc001pep.2	+	7	1390	c.1233T>G	c.(1231-1233)AGT>AGG	p.S411R	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	411	Plastocyanin-like 3.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GTCTTTTCAGTGACTCTGATC	0.368000													8	21					0	0	0	0
CADM1	23705	broad.mit.edu	37	11	115102137	115102137	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr11:115102137G>A	uc001ppi.3	-	4	627	c.498C>T	c.(496-498)TGC>TGT	p.C166C	CADM1_uc001ppf.3_Silent_p.C166C|CADM1_uc001ppk.3_Silent_p.C166C|CADM1_uc001ppj.3_Silent_p.C166C|CADM1_uc001ppl.2_Silent_p.C166C	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	166	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		CCATAGCAGTGCAGTTGACTT	0.458000													29	56					0	0	0	0
BSX	390259	broad.mit.edu	37	11	122852272	122852272	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr11:122852272C>T	uc010rzs.1	-	1	108	c.108G>A	c.(106-108)GTG>GTA	p.V36V		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	36											0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		GGTCTGGGGCCACCTCTCTCA	0.612000													3	4					0	0	0	0
OR6T1	219874	broad.mit.edu	37	11	123814471	123814471	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr11:123814471G>T	uc010sab.1	-	1	75	c.75C>A	c.(73-75)TTC>TTA	p.F25L		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GGAACACCAGGAACTGTATGA	0.488000													36	74					5.43694e-19	2.35519e-18	1	0
Unknown	0	broad.mit.edu	37	11	124121200	124121200	+	IGR	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr11:124121200T>A								OR8G2 (24890 upstream) : OR8D1 (58537 downstream)																							ATTCATGTAGTTGCAGCCATC	0.463000													27	60					0	0	0	0
B4GALNT3	283358	broad.mit.edu	37	12	666883	666883	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr12:666883G>A	uc001qii.1	+	16	2490	c.2490G>A	c.(2488-2490)GAG>GAA	p.E830E	B4GALNT3_uc001qik.1_Silent_p.E379E	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	830	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			ATAGCAGTGAGGACATGGATG	0.522000													14	21					0	0	0	0
SOX5	6660	broad.mit.edu	37	12	23999030	23999030	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr12:23999030G>A	uc001rfw.2	-	3	470	c.368C>T	c.(367-369)TCC>TTC	p.S123F	SOX5_uc001rfx.2_Missense_Mutation_p.S110F|SOX5_uc001rfy.2_Missense_Mutation_p.S110F|SOX5_uc010siv.1_Missense_Mutation_p.S110F|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.S75F|SOX5_uc001rga.2_Missense_Mutation_p.S88F	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	123					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						ACTAGACAAGGACTCGCCACT	0.493000													33	53					0	0	0	0
FAR2	55711	broad.mit.edu	37	12	29469874	29469874	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr12:29469874G>A	uc001ris.3	+	9	1203	c.1056G>A	c.(1054-1056)TGG>TGA	p.W352*	FAR2_uc001rit.2_Nonsense_Mutation_p.W352*|FAR2_uc009zjm.2_Nonsense_Mutation_p.W255*|uc001riu.1_Intron	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	352					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0						CACAGTACTGGAATGCGGTCA	0.498000													17	215					0	0	0	0
LRRK2	120892	broad.mit.edu	37	12	40748281	40748281	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr12:40748281T>A	uc001rmg.3	+	45	6878	c.6757T>A	c.(6757-6759)TTT>ATT	p.F2253I	LRRK2_uc009zjw.2_Missense_Mutation_p.F1091I|LRRK2_uc001rmi.2_Missense_Mutation_p.F1086I	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2253					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTGCAATTCCTTTTCCAAGCA	0.373000													8	20					0	0	0	0
OR8S1	341568	broad.mit.edu	37	12	48920192	48920192	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr12:48920192C>G	uc010slu.1	+	1	778	c.778C>G	c.(778-780)CTC>GTC	p.L260V		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCTCCGCCATCTCATGCCAAA	0.498000													22	49					0	0	0	0
HOXC9	3225	broad.mit.edu	37	12	54396248	54396248	+	Silent	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr12:54396248C>A	uc001sep.2	+	3	671	c.573C>A	c.(571-573)TCC>TCA	p.S191S	HOXC9_uc001seq.2_Silent_p.S191S	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	191					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						ACGCCCGCTCCACGAGGAAGA	0.567000													6	109					5.18039e-06	1.97797e-05	1	0
CDK4	1019	broad.mit.edu	37	12	58142978	58142978	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr12:58142978G>A	uc001spv.2	-	7	1033	c.806C>T	c.(805-807)GCA>GTA	p.A269V	CDK4_uc010ssb.1_Missense_Mutation_p.A149V|CDK4_uc001spw.2_RNA|uc010ssc.1_5'Flank	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	269	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CAGCAGCTGTGCTCCCGACTC	0.602000			Mis			melanoma 			Hereditary_Melanoma				18	74					0	0	0	0
GLIPR1	11010	broad.mit.edu	37	12	75889388	75889388	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr12:75889388G>A	uc001sxs.2	+	4	713	c.565G>A	c.(565-567)GGA>AGA	p.G189R	GLIPR1_uc009zsb.1_Silent_p.E212E	NM_006851	NP_006842	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1 precursor	189					cellular lipid metabolic process	extracellular region|integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3						ATATAAGAGAGGAGCCACCTG	0.378000													3	24					0	0	0	0
C12orf12	196477	broad.mit.edu	37	12	91348312	91348312	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr12:91348312G>T	uc001tbj.2	-	1	642	c.208C>A	c.(208-210)CAG>AAG	p.Q70K		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	70										central_nervous_system(1)|pancreas(1)	2						GGGCCGTGCTGTTGCTTCGGC	0.642000													12	16					1.08611e-07	4.23057e-07	1	0
TMEM132B	114795	broad.mit.edu	37	12	126138423	126138424	+	Missense_Mutation	DNP	GA	TG	TG			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr12:126138423_126138424GA>TG	uc001uhe.1	+	9	2412_2413	c.2404_2405GA>TG	c.(2404-2406)GAT>TGT	p.D802C	TMEM132B_uc001uhf.1_Missense_Mutation_p.D314C	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	802	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AGGCAGCAATGATATTGAGGGC	0.475000													6	57					0	0	0	0
N6AMT2	221143	broad.mit.edu	37	13	21331600	21331600	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr13:21331600C>T	uc001uno.1	-	2	219	c.138G>A	c.(136-138)GAG>GAA	p.E46E	N6AMT2_uc009zzr.1_Silent_p.E46E|N6AMT2_uc001unp.2_RNA	NM_174928	NP_777588	Q8WVE0	N6MT2_HUMAN	N-6 adenine-specific DNA methyltransferase 2	46							methyltransferase activity|nucleic acid binding				0		all_cancers(29;5.91e-19)|all_epithelial(30;1.42e-15)|all_lung(29;5.9e-14)|Lung SC(185;0.0367)		all cancers(112;0.000234)|Epithelial(112;0.000471)|OV - Ovarian serous cystadenocarcinoma(117;0.0111)|Lung(94;0.0161)|LUSC - Lung squamous cell carcinoma(192;0.0431)		TTACCCAATTCTCTTCTATTA	0.418000													23	57					0	0	0	0
STARD13	90627	broad.mit.edu	37	13	33703125	33703125	+	Silent	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr13:33703125A>G	uc001uuw.2	-	5	1815	c.1689T>C	c.(1687-1689)CCT>CCC	p.P563P	STARD13_uc001uuu.2_Silent_p.P555P|STARD13_uc001uuv.2_Silent_p.P445P|STARD13_uc001uux.2_Silent_p.P528P|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Silent_p.P548P	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	563					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		TGACCCCAGGAGGCTCAGATT	0.473000													18	32					0	0	0	0
LRCH1	23143	broad.mit.edu	37	13	47315858	47315859	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr13:47315858_47315859GG>TT	uc001vbj.2	+	19	2298_2299	c.2062_2063GG>TT	c.(2062-2064)GGG>TTG	p.G688L	LRCH1_uc001vbk.2_Missense_Mutation_p.G723L|LRCH1_uc001vbl.3_Intron	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	688	CH.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		GCTGGCACTCGGGGAGAAAGCC	0.515000													8	419					0	0	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368987	86368987	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr13:86368987C>T	uc001vll.1	-	2	2116	c.1657G>A	c.(1657-1659)GAC>AAC	p.D553N	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	553	LRRCT 2.|Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TCCTTTTTGTCGAGATGCCCG	0.458000													11	54					0	0	0	0
OXGR1	27199	broad.mit.edu	37	13	97639754	97639754	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr13:97639754G>T	uc001vmx.1	-	4	504	c.260C>A	c.(259-261)CCC>CAC	p.P87H	OXGR1_uc010afr.1_Missense_Mutation_p.P87H	NM_080818	NP_543008	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	87	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			AATCAGGAAGGGGAGGCTGGT	0.453000													10	16					2.17888e-05	8.18987e-05	1	0
OR4K5	79317	broad.mit.edu	37	14	20389043	20389043	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr14:20389043C>A	uc010tkw.1	+	1	278	c.278C>A	c.(277-279)TCT>TAT	p.S93Y		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GAGACCATATCTTTCAGTGGC	0.418000													57	295					8.99859e-20	3.9156e-19	1	0
NOVA1	4857	broad.mit.edu	37	14	26918046	26918046	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr14:26918046T>A	uc001wpy.2	-	5	961	c.643A>T	c.(643-645)AAC>TAC	p.N215Y	NOVA1_uc001wpz.2_Missense_Mutation_p.N191Y|NOVA1_uc001wqa.2_Missense_Mutation_p.N93Y	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	218	KH 2.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		TCTTGCAAGTTGATCCCATCA	0.488000													43	76					0	0	0	0
BAZ1A	11177	broad.mit.edu	37	14	35245154	35245154	+	Missense_Mutation	SNP	C	T	T	rs116485187	by1000genomes	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr14:35245154C>T	uc001wsk.2	-	18	3372	c.2804G>A	c.(2803-2805)CGT>CAT	p.R935H	BAZ1A_uc001wsl.2_Missense_Mutation_p.R903H	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	935					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TTCAGAAAAACGGGCTAGCTG	0.353000													10	29					0	0	0	0
Unknown	0	broad.mit.edu	37	14	66479779	66479779	+	Silent	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr14:66479779T>C	uc001xit.2	-	1	854	c.729A>G	c.(727-729)AGA>AGG	p.R243R						SubName: Full=Nuclease sensitive element binding protein-1;																		GAGGAGGGCCTCTGCGGAATC	0.522000													5	74					0	0	0	0
SLC8A3	6547	broad.mit.edu	37	14	70633784	70633784	+	Silent	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr14:70633784C>A	uc001xly.2	-	2	2110	c.1356G>T	c.(1354-1356)ACG>ACT	p.T452T	SLC8A3_uc001xlw.2_Silent_p.T452T|SLC8A3_uc001xlx.2_Silent_p.T452T|SLC8A3_uc001xlz.2_Silent_p.T452T|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	452	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCAGAACCACCGTGCCCTCTG	0.488000													45	106					1.7489e-18	7.54215e-18	1	0
SLC8A3	6547	broad.mit.edu	37	14	70634902	70634902	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr14:70634902A>G	uc001xly.2	-	2	992	c.238T>C	c.(238-240)TAT>CAT	p.Y80H	SLC8A3_uc001xlw.2_Missense_Mutation_p.Y80H|SLC8A3_uc001xlx.2_Missense_Mutation_p.Y80H|SLC8A3_uc001xlz.2_Missense_Mutation_p.Y80H|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	80	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GCCACAAAATAGACAATGACC	0.522000													12	24					0	0	0	0
PTPN21	11099	broad.mit.edu	37	14	88940131	88940131	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr14:88940131G>A	uc001xwv.3	-	14	2858	c.2527C>T	c.(2527-2529)CGA>TGA	p.R843*	PTPN21_uc010twc.1_Nonsense_Mutation_p.R639*	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	843						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						GCATCTACTCGAGTCTTTTTC	0.398000													5	41					0	0	0	0
TECPR2	9895	broad.mit.edu	37	14	102900897	102900897	+	Silent	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr14:102900897G>T	uc001ylw.1	+	9	1891	c.1743G>T	c.(1741-1743)CTG>CTT	p.L581L	TECPR2_uc010awl.2_Silent_p.L581L|TECPR2_uc010txx.1_Intron	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	581							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						GGCGGGAGCTGCTCAATGGAG	0.532000													11	30					1.58986e-06	6.11876e-06	1	0
ADAM6	8755	broad.mit.edu	37	14	107042588	107042588	+	RNA	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr14:107042588G>T	uc010tyt.1	-	148		c.7029C>A								Parts of antibodies, mostly variable regions.												0						TCCAGAGGCTGCACAGGAGAG	0.597000													26	54					3.7963e-18	1.61552e-17	1	0
SNURF	8926	broad.mit.edu	37	15	25213157	25213157	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr15:25213157C>T	uc001ywu.2	+	3	315	c.189C>T	c.(187-189)TTC>TTT	p.F63F	SNRPN_uc001ywp.1_5'UTR|SNRPN_uc001ywq.1_5'UTR|SNRPN_uc001ywr.1_5'UTR|SNRPN_uc001yws.1_Intron|SNRPN_uc001ywt.1_5'UTR|SNRPN_uc001ywv.1_5'UTR|SNRPN_uc001yww.1_5'UTR|SNRPN_uc001ywx.1_5'UTR|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_RNA|SNRPN_uc001ywy.1_Silent_p.F63F	NM_022804	NP_073715	Q9Y675	SNURF_HUMAN	SNRPN upstream reading frame protein	63						nucleus					0		all_cancers(20;1.4e-21)|Breast(32;0.000625)		all cancers(64;3.48e-07)|Epithelial(43;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0142)		GGCAGGCATTCTTAGCTGAGA	0.468000													4	60					0	0	0	0
PAR4	347745	broad.mit.edu	37	15	25451254	25451254	+	RNA	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr15:25451254C>A	uc001yzk.1	+	10		c.1472C>A			PAR4_uc010ayo.1_Intron|SNORD115-20_uc001yzq.1_5'Flank					Homo sapiens clone Rt-13I SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0						GAGGAAGACCCCGTGGCTCTG	0.642000													13	17					7.03913e-09	2.79827e-08	1	0
ATP10A	57194	broad.mit.edu	37	15	25959362	25959362	+	Silent	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr15:25959362G>T	uc010ayu.2	-	10	1909	c.1803C>A	c.(1801-1803)TCC>TCA	p.S601S		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	601	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TCTTCACCGGGGACTTCAGCT	0.607000													16	31					6.31663e-08	2.48043e-07	1	0
TJP1	7082	broad.mit.edu	37	15	30003119	30003119	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr15:30003119G>C	uc001zcr.2	-	24	4763	c.4288C>G	c.(4288-4290)CCA>GCA	p.P1430A	TJP1_uc010azl.2_Missense_Mutation_p.P1418A|TJP1_uc001zcq.2_Missense_Mutation_p.P1354A|TJP1_uc001zcs.2_Missense_Mutation_p.P1350A	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1430	Poly-Pro.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GAGGGCAATGGAGGAGGAGGG	0.532000													76	109					0	0	0	0
TJP1	7082	broad.mit.edu	37	15	30033539	30033539	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr15:30033539G>A	uc001zcr.2	-	10	1727	c.1252C>T	c.(1252-1254)CTT>TTT	p.L418F	TJP1_uc010azl.2_Missense_Mutation_p.L406F|TJP1_uc001zcq.2_Missense_Mutation_p.L422F|TJP1_uc001zcs.2_Missense_Mutation_p.L418F	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	418					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TATTACCGAAGAATCCCATCT	0.338000													19	23					0	0	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42107957	42107957	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr15:42107957G>C	uc001zok.3	+	13	1757	c.1471G>C	c.(1471-1473)GGA>CGA	p.G491R	MAPKBP1_uc001zoj.3_Missense_Mutation_p.G485R|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Missense_Mutation_p.G485R|MAPKBP1_uc010udb.1_Missense_Mutation_p.G324R|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	491	WD 7.									central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CAGCCCCAATGGACAGCATCT	0.592000													10	26					0	0	0	0
USP8	9101	broad.mit.edu	37	15	50788056	50788056	+	Silent	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr15:50788056G>C	uc001zym.3	+	18	3170	c.2670G>C	c.(2668-2670)CGG>CGC	p.R890R	USP8_uc001zyl.3_Silent_p.R890R|USP8_uc001zyn.3_Silent_p.R890R|USP8_uc010ufh.1_Silent_p.R784R|uc001zyo.1_5'Flank|USP8_uc001zyp.3_Silent_p.R57R	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	890					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		CTGATAATCGGAAGAGATATA	0.318000													6	16					0	0	0	0
ALPK3	57538	broad.mit.edu	37	15	85399896	85399896	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr15:85399896G>T	uc002ble.2	+	6	2700	c.2533G>T	c.(2533-2535)GCT>TCT	p.A845S		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	845					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCAGGTGGATGCTGGGACACA	0.547000													9	26					5.4927e-09	2.19254e-08	1	0
MAN2A2	4122	broad.mit.edu	37	15	91455444	91455444	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr15:91455444A>C	uc010bnz.2	+	15	2396	c.2281A>C	c.(2281-2283)AGC>CGC	p.S761R	MAN2A2_uc002bqc.2_Missense_Mutation_p.S761R|MAN2A2_uc010uql.1_Missense_Mutation_p.S423R|MAN2A2_uc010uqm.1_Missense_Mutation_p.S340R|MAN2A2_uc010uqn.1_RNA	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	761	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			CTCTGGCACCAGCGACTTCGC	0.637000													30	66					0	0	0	0
Unknown	0	broad.mit.edu	37	15	102292797	102292797	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr15:102292797C>G	uc010usj.1	+	4	444	c.385C>G	c.(385-387)CCA>GCA	p.P129A	uc002bxo.2_RNA|uc002bxp.3_5'Flank|uc002bxt.2_5'Flank|uc002bxz.3_5'Flank|uc002byd.2_5'Flank|uc002bye.2_5'Flank|uc002byf.1_5'Flank|uc002byg.2_5'Flank|uc002byi.2_5'Flank|uc002byk.2_5'Flank|uc002bym.2_5'Flank|uc002byn.2_5'Flank|uc010usm.1_5'Flank					RecName: Full=Uncharacterized protein C15orf51.; Flags: Fragment;																		GAGCTGCTGTCCAACCTGCAC	0.597000													4	25					0	0	0	0
PHKB	5257	broad.mit.edu	37	16	47627442	47627442	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr16:47627442T>C	uc002eev.3	+	11	1152	c.1100T>C	c.(1099-1101)ATA>ACA	p.I367T	PHKB_uc002eeu.3_Missense_Mutation_p.I360T	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	367					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				GAATTTCCCATATTTTTCCTT	0.229000													10	18					0	0	0	0
CES2	8824	broad.mit.edu	37	16	66976677	66976677	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr16:66976677G>A	uc002eqr.2	+	10	2601	c.1601G>A	c.(1600-1602)GGG>GAG	p.G534E	CES2_uc002eqq.2_Intron|CES2_uc002eqs.2_Missense_Mutation_p.G377E	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	470					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		AGTTTCTTTGGGGGCAACTAC	0.473000													8	47					0	0	0	0
MYH8	4626	broad.mit.edu	37	17	10318656	10318656	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:10318656C>G	uc002gmm.2	-	8	789	c.694G>C	c.(694-696)GCC>CCC	p.A232P	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	232	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TTGCCAAAGGCCTCCAGTAGG	0.502000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				28	75					0	0	0	0
DNAH9	1770	broad.mit.edu	37	17	11573072	11573072	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:11573072T>G	uc002gne.2	+	17	3382	c.3314T>G	c.(3313-3315)CTC>CGC	p.L1105R	DNAH9_uc010coo.2_Missense_Mutation_p.L399R	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1105	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGGTGGAGCCTCCTGTTCAAA	0.453000													40	95					0	0	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319765	21319765	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:21319765A>T	uc002gyv.1	+	3	1816	c.1111A>T	c.(1111-1113)AGC>TGC	p.S371C		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	371	Cytoplasmic (By similarity).			S -> R (in Ref. 2; AAC50615).	blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CCTGCTGCCCAGCGCCAACTC	0.607000										Prostate(3;0.18)			5	84					0	0	0	0
Unknown	0	broad.mit.edu	37	17	34234112	34234112	+	RNA	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:34234112G>T	uc010ctx.1	-	1		c.2842C>A								Homo sapiens cDNA FLJ43944 fis, clone TESTI4014392.																		GGGGCCGCCTGCTGGGCTGGA	0.517000													8	57					1.06961e-07	4.18318e-07	1	0
ERBB2	2064	broad.mit.edu	37	17	37881982	37881982	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:37881982G>A	uc002hso.2	+	23	2986	c.2748G>A	c.(2746-2748)ATG>ATA	p.M916I	ERBB2_uc002hsm.2_Missense_Mutation_p.M886I|ERBB2_uc010cwa.2_Missense_Mutation_p.M901I|ERBB2_uc002hsp.2_Missense_Mutation_p.M719I|ERBB2_uc010cwb.2_Missense_Mutation_p.M916I|ERBB2_uc010wek.1_Missense_Mutation_p.M640I	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	916	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GGGAGCTGATGACTTTTGGGG	0.602000		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			6	64					0	0	0	0
BRCA1	672	broad.mit.edu	37	17	41222997	41222997	+	Missense_Mutation	SNP	C	A	A	rs80357653		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:41222997C>A	uc002icq.2	-	15	5166	c.4934G>T	c.(4933-4935)AGG>ATG	p.R1645M	BRCA1_uc010whp.1_Missense_Mutation_p.R494M|BRCA1_uc010whl.1_Missense_Mutation_p.R541M|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.R1574M|BRCA1_uc002icu.2_Missense_Mutation_p.R541M|BRCA1_uc010cyx.2_Missense_Mutation_p.R1598M|BRCA1_uc002ict.2_Missense_Mutation_p.R1666M|BRCA1_uc010whn.1_Missense_Mutation_p.R136M|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Missense_Mutation_p.R374M|BRCA1_uc002idc.1_Missense_Mutation_p.R541M|BRCA1_uc010whr.1_Missense_Mutation_p.R495M	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	1645	BRCT 1.				androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TTTGTTGACCCTTTCTGTTGA	0.443000			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			59	64					3.00063e-23	1.31755e-22	1	0
ASB16	92591	broad.mit.edu	37	17	42248236	42248236	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:42248236G>C	uc002ifl.1	+	1	163	c.79G>C	c.(79-81)GAC>CAC	p.D27H	ASB16_uc002ifm.1_RNA	NM_080863	NP_543139	Q96NS5	ASB16_HUMAN	ankyrin repeat and SOCS box-containing protein	27					intracellular signal transduction		protein binding			kidney(2)	2		Breast(137;0.00765)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GGAATGGGAGGACCGGCGGCG	0.697000													10	45					0	0	0	0
Unknown	0	broad.mit.edu	37	17	45128671	45128671	+	5'Flank	SNP	T	G	G	rs1056072	by1000genomes	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:45128671T>G	uc010wkl.1	-						uc010wkm.1_RNA					Homo sapiens cDNA FLJ38031 fis, clone CTONG2013348.																		GCTCACAAAATAAGTTCCAGG	0.308000													4	136					0	0	0	0
SKAP1	8631	broad.mit.edu	37	17	46239901	46239901	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:46239901C>T	uc002ini.1	-	11	1020	c.908G>A	c.(907-909)TGG>TAG	p.W303*	SKAP1_uc002inj.1_Nonsense_Mutation_p.W302*|SKAP1_uc010dbd.1_Nonsense_Mutation_p.W208*|SKAP1_uc010dbe.1_Nonsense_Mutation_p.W303*	NM_003726	NP_003717	Q86WV1	SKAP1_HUMAN	src kinase associated phosphoprotein 1 isoform	303	SH3.				positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway	cytoplasm|nucleus|plasma membrane	antigen binding|protein kinase binding|SH2 domain binding				0						ATGGCAATCCCATAGGCCCTG	0.463000													12	70					0	0	0	0
HOXB2	3212	broad.mit.edu	37	17	46620658	46620658	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:46620658C>T	uc002inm.2	-	2	963	c.843G>A	c.(841-843)GGG>GGA	p.G281G		NM_002145	NP_002136	P14652	HXB2_HUMAN	homeobox B2	281					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCCGCCGGCCCCGCGCAGCG	0.711000													9	48					0	0	0	0
CA10	56934	broad.mit.edu	37	17	49726560	49726560	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:49726560G>C	uc002itw.3	-	6	1603	c.617C>G	c.(616-618)ACA>AGA	p.T206R	CA10_uc002itu.3_Missense_Mutation_p.T135R|CA10_uc002itv.3_Missense_Mutation_p.T212R|CA10_uc002itx.3_Missense_Mutation_p.T206R|CA10_uc002ity.3_Missense_Mutation_p.T206R|CA10_uc002itz.2_Missense_Mutation_p.T206R	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	206					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TGTTATTCTTGTGATAGTATC	0.284000													5	62					0	0	0	0
SCPEP1	59342	broad.mit.edu	37	17	55072947	55072947	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:55072947A>G	uc002iuv.3	+	8	790	c.737A>G	c.(736-738)TAC>TGC	p.Y246C	SCPEP1_uc010dcl.2_RNA|SCPEP1_uc010wnk.1_Missense_Mutation_p.Y196C	NM_021626	NP_067639	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1 precursor	246					proteolysis	extracellular region	serine-type carboxypeptidase activity			skin(1)	1	Breast(9;2.86e-08)					AAGGGGCTCTACAGAGAGGCC	0.498000													6	118					0	0	0	0
TTYH2	94015	broad.mit.edu	37	17	72233624	72233624	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:72233624C>T	uc002jkc.2	+	4	637	c.606C>T	c.(604-606)TCC>TCT	p.S202S	TTYH2_uc010wqw.1_Silent_p.S181S	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	202	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4						CCAAGCTATCCGACCAGACTG	0.572000													7	64					0	0	0	0
DNAI2	64446	broad.mit.edu	37	17	72285736	72285736	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:72285736C>T	uc002jkf.2	+	5	570	c.471C>T	c.(469-471)GAC>GAT	p.D157D	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	157					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						CCTGCAGGGACCCCCAGGAAA	0.483000									Kartagener_syndrome				22	34					0	0	0	0
CCDC40	55036	broad.mit.edu	37	17	78055742	78055742	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:78055742G>T	uc010dht.2	+	12	1901	c.1874G>T	c.(1873-1875)AGG>ATG	p.R625M	CCDC40_uc002jxm.3_Missense_Mutation_p.R408M|CCDC40_uc002jxn.3_Missense_Mutation_p.R21M	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	625	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CTGGAGCTCAGGAGGAAGACG	0.577000													9	36					3.09899e-07	1.19745e-06	1	0
EPB41L3	23136	broad.mit.edu	37	18	5415995	5415995	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr18:5415995G>A	uc002kmt.1	-	13	1975	c.1889C>T	c.(1888-1890)CCG>CTG	p.P630L	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Intron|EPB41L3_uc010wzf.1_Intron|EPB41L3_uc010wzg.1_Intron|EPB41L3_uc010dkr.2_Intron	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	630	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CACAAGGGACGGTGAGCGGAT	0.542000													18	59					0	0	0	0
NOL4	8715	broad.mit.edu	37	18	31432903	31432903	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr18:31432903T>C	uc010dmi.2	-	11	2049	c.1820A>G	c.(1819-1821)AAT>AGT	p.N607S	NOL4_uc010xbs.1_Missense_Mutation_p.N322S|NOL4_uc002kxr.3_Missense_Mutation_p.N379S|NOL4_uc010xbt.1_Missense_Mutation_p.N533S|NOL4_uc010dmh.2_Missense_Mutation_p.N469S|NOL4_uc010xbu.1_Missense_Mutation_p.N543S|NOL4_uc002kxt.3_Missense_Mutation_p.N505S	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	607						nucleolus	RNA binding			ovary(3)	3						TCTCACGGCATTGATTTCAGT	0.468000													25	49					0	0	0	0
TSHZ1	10194	broad.mit.edu	37	18	73000493	73000493	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr18:73000493G>A	uc002lly.2	+	2	3559	c.2996G>A	c.(2995-2997)CGG>CAG	p.R999Q		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	1044	C2H2-type 5.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CTCTGCAACCGGACTTTTGCG	0.532000													24	53					0	0	0	0
APC2	10297	broad.mit.edu	37	19	1467216	1467216	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:1467216G>A	uc002lsr.1	+	15	4124	c.3916G>A	c.(3916-3918)GGG>AGG	p.G1306R	APC2_uc002lss.1_Missense_Mutation_p.G888R|APC2_uc002lst.1_Missense_Mutation_p.G1306R|APC2_uc002lsu.1_Missense_Mutation_p.G1305R|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	1306	Interaction with CTNNB1.|5 X 20 AA approximate repeat of F-X-V-E- X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-S.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGAgcgcggcgggggcgccgg	0.642000													4	11					0	0	0	0
SNAPC2	6618	broad.mit.edu	37	19	7986386	7986386	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:7986386G>A	uc002miw.1	+	2	285	c.262G>A	c.(262-264)GGA>AGA	p.G88R	SNAPC2_uc002mix.1_RNA	NM_003083	NP_003074	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex,	88					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity				0						TGGCCTTCAGGGACCAAGGCG	0.657000													21	36					0	0	0	0
SMARCA4	6597	broad.mit.edu	37	19	11105592	11105592	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:11105592C>A	uc002mqf.3	+	9	1792	c.1508C>A	c.(1507-1509)GCA>GAA	p.A503E	SMARCA4_uc010dxp.2_Missense_Mutation_p.A503E|SMARCA4_uc010dxo.2_Missense_Mutation_p.A503E|SMARCA4_uc002mqg.1_Missense_Mutation_p.A503E|SMARCA4_uc010dxq.2_Missense_Mutation_p.A503E|SMARCA4_uc010dxr.2_Missense_Mutation_p.A503E|SMARCA4_uc002mqj.3_Missense_Mutation_p.A503E|SMARCA4_uc010dxs.2_Missense_Mutation_p.A503E|SMARCA4_uc002mqe.2_Missense_Mutation_p.A503E	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	503	HSA.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CTGACCAAGGCAGTGGCCACG	0.532000			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				4	21					3.86212e-05	0.000142943	1	0
SMARCA4	6597	broad.mit.edu	37	19	11141507	11141507	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:11141507G>T	uc002mqf.3	+	25	3768	c.3484G>T	c.(3484-3486)GGC>TGC	p.G1162C	SMARCA4_uc010dxp.2_Missense_Mutation_p.G1162C|SMARCA4_uc010dxo.2_Missense_Mutation_p.G1162C|SMARCA4_uc002mqg.1_Missense_Mutation_p.G1162C|SMARCA4_uc010dxq.2_Missense_Mutation_p.G1162C|SMARCA4_uc010dxr.2_Missense_Mutation_p.G1162C|SMARCA4_uc002mqj.3_Missense_Mutation_p.G1162C|SMARCA4_uc010dxs.2_Missense_Mutation_p.G1162C|SMARCA4_uc010dxt.1_Missense_Mutation_p.G382C|SMARCA4_uc002mqh.3_Missense_Mutation_p.G285C|SMARCA4_uc002mqi.1_Missense_Mutation_p.G365C	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1162	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				TGGGGGGCTCGGCCTGAACCT	0.607000			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				6	7					3.59834e-05	0.000134728	1	0
ZNF844	284391	broad.mit.edu	37	19	12187076	12187076	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:12187076G>C	uc002mtb.2	+	4	1284	c.1141G>C	c.(1141-1143)GAC>CAC	p.D381H	ZNF844_uc010dym.1_Missense_Mutation_p.D224H	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	381					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCGTTTTGAAGACATGAAAGA	0.383000													7	21					0	0	0	0
CHERP	10523	broad.mit.edu	37	19	16640580	16640580	+	Silent	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:16640580T>C	uc002nei.1	-	8	1082	c.1008A>G	c.(1006-1008)CAA>CAG	p.Q336Q	MED26_uc002nee.2_Intron	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	336	Gln-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						gctgctgctgttgctgctgct	0.547000													3	40					0	0	0	0
ZNF486	90649	broad.mit.edu	37	19	20308131	20308131	+	Silent	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:20308131T>C	uc002nou.2	+	4	669	c.612T>C	c.(610-612)GAT>GAC	p.D204D		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AAAAAATTGATACTGGAGAGA	0.358000													18	38					0	0	0	0
ZNF568	374900	broad.mit.edu	37	19	37441482	37441482	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:37441482G>A	uc002ofc.2	+	7	1942	c.1427G>A	c.(1426-1428)TGC>TAC	p.C476Y	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.C400Y|ZNF568_uc010efe.2_Missense_Mutation_p.C400Y|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	476	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCTTATGAATGCAGTGAATGT	0.393000													20	61					0	0	0	0
ZNF585B	92285	broad.mit.edu	37	19	37677286	37677286	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:37677286T>A	uc002ofq.2	-	5	1407	c.1153A>T	c.(1153-1155)AGT>TGT	p.S385C	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.S199C	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	385	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCACAGTCACTGCATTCATAA	0.428000													10	56					0	0	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38652910	38652910	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:38652910C>G	uc002ohk.2	+	14	4188	c.3679C>G	c.(3679-3681)CCT>GCT	p.P1227A		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1227					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GTGGCATGTGCCTGCCCAGGC	0.582000													4	51					0	0	0	0
SERTAD1	29950	broad.mit.edu	37	19	40929342	40929342	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:40929342G>A	uc002ont.3	-	2	271	c.112C>T	c.(112-114)CCG>TCG	p.P38S		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	38	SERTA.				positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCCACGGCCGGGGGTGCCTGT	0.647000													12	21					0	0	0	0
PSG7	5676	broad.mit.edu	37	19	43433722	43433722	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:43433722T>A	uc002ovl.3	-	4	683	c.581A>T	c.(580-582)CAG>CTG	p.Q194L	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_5'Flank|PSG7_uc002out.1_Missense_Mutation_p.Q13L|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.Q72L	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	194	Ig-like C2-type 1.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				TTCAGACAGCTGCAAGCTGTG	0.512000													138	254					0	0	0	0
PRR12	57479	broad.mit.edu	37	19	50099588	50099588	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:50099588G>A	uc002poo.3	+	4	1996	c.1996G>A	c.(1996-1998)GGG>AGG	p.G666R		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GGGCGAGGACGGGGCAGCAGA	0.672000													4	11					0	0	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51633226	51633226	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:51633226G>T	uc002pvu.2	+	7	1349	c.1282G>T	c.(1282-1284)GAA>TAA	p.E428*	SIGLEC9_uc010yct.1_Intron	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	428	Cytoplasmic (Potential).				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		CTCAGTGGGGGAAGGAGAGCT	0.607000													9	77					0.000274275	0.00099981	1	0
ZNF808	388558	broad.mit.edu	37	19	53058290	53058290	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:53058290C>T	uc010epq.1	+	5	2298	c.2121C>T	c.(2119-2121)TAC>TAT	p.Y707Y	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	707	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TGAAACCTTACAAGTGTAATG	0.413000													19	250					0	0	0	0
VN1R2	317701	broad.mit.edu	37	19	53762612	53762612	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:53762612C>T	uc002qbi.2	+	1	1068	c.984C>T	c.(982-984)TAC>TAT	p.Y328Y		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	328	Helical; Name=6; (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		CATTATGTTACGCCCTTTCCT	0.443000													45	109					0	0	0	0
CACNG6	59285	broad.mit.edu	37	19	54496175	54496175	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:54496175G>C	uc002qct.2	+	1	634	c.44G>C	c.(43-45)CGG>CCG	p.R15P	CACNG6_uc002qcu.2_Missense_Mutation_p.R15P|CACNG6_uc002qcv.2_Missense_Mutation_p.R15P	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	15						voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		AAccggcggcggggggccgcg	0.562000													8	17					0	0	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55294944	55294944	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:55294944C>T	uc002qhb.1	+	7	862	c.824C>T	c.(823-825)GCG>GTG	p.A275V	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL4_uc010yfl.1_5'Flank|KIR2DL3_uc010erw.1_Missense_Mutation_p.A276V|KIR2DL1_uc002qgz.1_Missense_Mutation_p.A185V|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Missense_Mutation_p.A301V	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	275	Cytoplasmic (Potential).				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		ACAGATGCTGCGGTAATGGAC	0.517000													11	55					0	0	0	0
ZNF550	162972	broad.mit.edu	37	19	58058918	58058918	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr19:58058918C>G	uc002qpe.1	-	2	571	c.571G>C	c.(571-573)GAA>CAA	p.E191Q	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF550_uc002qpc.2_RNA|ZNF550_uc010eue.1_RNA|ZNF550_uc002qpd.2_RNA	NM_001039654	NP_001034743	Q7Z398	ZN550_HUMAN	zinc finger protein 550	232	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GCATTGCATTCATAGGGTTTC	0.488000													16	38					0	0	0	0
PXDN	7837	broad.mit.edu	37	2	1651956	1651956	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:1651956T>C	uc002qxa.2	-	17	3660	c.3596A>G	c.(3595-3597)GAG>GGG	p.E1199G		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1199					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TTTCAGTTTCTCCCGGATCTC	0.512000													34	202					0	0	0	0
ROCK2	9475	broad.mit.edu	37	2	11367521	11367521	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:11367521C>T	uc002rbd.1	-	6	1176	c.727G>A	c.(727-729)GGC>AGC	p.G243S		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	243	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TGTACCATGCCTGTCTGCATG	0.373000													54	130					0	0	0	0
DNMT3A	1788	broad.mit.edu	37	2	25468197	25468197	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:25468197G>A	uc002rgc.2	-	13	1736	c.1479C>T	c.(1477-1479)ATC>ATT	p.I493I	DNMT3A_uc002rgd.2_Silent_p.I493I|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Silent_p.I304I	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	493	GATA-type; atypical.|ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAGATGCAGATGTCTGGAA	0.602000			Mis|F|N|S		AML								34	36					0	0	0	0
ANKRD20B	729171	broad.mit.edu	37	2	95513821	95513821	+	RNA	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:95513821G>A	uc010fhp.2	-	5		c.584C>T				NR_003366				Homo sapiens ankyrin repeat domain 20B (ANKRD20B), non-coding RNA.												0						TGTCTTGAGCGAAGACATCAA	0.353000													43	705					0	0	0	0
RGPD4	285190	broad.mit.edu	37	2	108488441	108488441	+	Silent	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:108488441A>G	uc010ywk.1	+	20	4063	c.3981A>G	c.(3979-3981)GAA>GAG	p.E1327E	RGPD4_uc002tdu.2_Silent_p.E514E|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1327					intracellular transport		binding			skin(2)	2						TTACTCAAGAAGAAGAGAGAG	0.393000													17	233					0	0	0	0
MERTK	10461	broad.mit.edu	37	2	112786077	112786077	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:112786077A>G	uc002thk.1	+	19	2758	c.2636A>G	c.(2635-2637)GAG>GGG	p.E879G	MERTK_uc002thl.1_Missense_Mutation_p.E703G	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	879	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						CAGTTGCTGGAGAGCTCTGAG	0.522000													43	164					0	0	0	0
SLC20A1	6574	broad.mit.edu	37	2	113417263	113417263	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:113417263G>A	uc002tib.2	+	8	1977	c.1531G>A	c.(1531-1533)GTC>ATC	p.V511I	SLC20A1_uc002tic.1_Missense_Mutation_p.V323I	NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	511	Helical; (Potential).				phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2						TAAGCCTGAAGTCTCTCTCCT	0.468000													11	163					0	0	0	0
IL1F6	27179	broad.mit.edu	37	2	113764229	113764229	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:113764229G>C	uc010yxr.1	+	3	179	c.179G>C	c.(178-180)GGG>GCG	p.G60A		NM_014440	NP_055255	Q9UHA7	IL36A_HUMAN	interleukin 1 family, member 6 (epsilon)	60					immune response|inflammatory response	extracellular space	cytokine activity|interleukin-1 receptor binding				0						AAAGACAGAGGGAACCCCATC	0.527000													61	221					0	0	0	0
EN1	2019	broad.mit.edu	37	2	119603946	119603946	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:119603946C>T	uc002tlm.2	-	1	1814	c.798G>A	c.(796-798)TCG>TCA	p.S266S		NM_001426	NP_001417	Q05925	HME1_HUMAN	engrailed homeobox 1	266					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)	2						GAGGCTGCTGCGAGTCAGTTT	0.637000													5	14					0	0	0	0
ZEB2	9839	broad.mit.edu	37	2	145156077	145156077	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:145156077G>A	uc002tvu.2	-	8	3157	c.2677C>T	c.(2677-2679)CCT>TCT	p.P893S	ZEB2_uc002tvv.2_Missense_Mutation_p.P887S|ZEB2_uc010zbm.1_Missense_Mutation_p.P864S|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Missense_Mutation_p.P922S	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	893						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		GTGTATAAAGGTTTGGCACTA	0.438000													9	177					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152423805	152423805	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:152423805G>A	uc010fnx.2	-	86	13121	c.12930C>T	c.(12928-12930)GCC>GCT	p.A4310A	NEB_uc002txr.2_Silent_p.A733A	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	4310	Nebulin 118.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCTGCTTGGCGGCCAAGACTG	0.438000													52	53					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152483591	152483591	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:152483591G>C	uc010fnx.2	-	66	9734	c.9543C>G	c.(9541-9543)GAC>GAG	p.D3181E		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3181	Nebulin 86.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		ATTTCAGCTTGTCCGGAGGCT	0.488000													9	111					0	0	0	0
COL3A1	1281	broad.mit.edu	37	2	189870100	189870100	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:189870100A>T	uc002uqj.1	+	41	3073	c.2956A>T	c.(2956-2958)AAC>TAC	p.N986Y		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	986	Triple-helical region.			ANGLS -> PSGQN (in Ref. 20; AA sequence).	axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	ACCAGGAGCTAACGGTCTCAG	0.433000													52	62					0	0	0	0
NRP2	8828	broad.mit.edu	37	2	206590770	206590770	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:206590770G>T	uc002vaw.2	+	6	1745	c.954G>T	c.(952-954)TGG>TGT	p.W318C	NRP2_uc002vat.2_Missense_Mutation_p.W318C|NRP2_uc002vau.2_Missense_Mutation_p.W318C|NRP2_uc002vav.2_Missense_Mutation_p.W318C|NRP2_uc002vax.2_Missense_Mutation_p.W318C|NRP2_uc002vay.2_Missense_Mutation_p.W318C|NRP2_uc010fud.2_Missense_Mutation_p.W318C	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	318	Extracellular (Potential).|F5/8 type C 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						ACAATGGCTGGACCCCCAACT	0.522000													15	40					1.52009e-12	6.27525e-12	1	0
IKZF2	22807	broad.mit.edu	37	2	213878608	213878608	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:213878608T>C	uc002vem.2	-	7	932	c.763A>G	c.(763-765)ATT>GTT	p.I255V	IKZF2_uc010fuu.2_Missense_Mutation_p.I110V|IKZF2_uc002vej.2_Missense_Mutation_p.I202V|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Intron|IKZF2_uc002vel.2_Missense_Mutation_p.I176V|IKZF2_uc010fuw.2_Missense_Mutation_p.I29V|IKZF2_uc010fux.2_Missense_Mutation_p.I29V|IKZF2_uc010fuy.2_Missense_Mutation_p.I183V|IKZF2_uc002ven.2_Missense_Mutation_p.I229V|IKZF2_uc002vei.2_Missense_Mutation_p.I33V	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		ACCAGAGAAATATTGTTGTCC	0.388000													38	70					0	0	0	0
SLC19A3	80704	broad.mit.edu	37	2	228560704	228560704	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:228560704C>T	uc002vpi.2	-	4	1162	c.1073G>A	c.(1072-1074)GGT>GAT	p.G358D	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.G354D	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	358	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	AAATAAAGAACCGGCATTGAC	0.468000													29	86					0	0	0	0
PAK7	57144	broad.mit.edu	37	20	9561116	9561116	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr20:9561116G>A	uc002wnl.2	-	5	1211	c.666C>T	c.(664-666)GCC>GCT	p.A222A	PAK7_uc002wnk.2_Silent_p.A222A|PAK7_uc002wnj.2_Silent_p.A222A|PAK7_uc010gby.1_Silent_p.A222A	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	222	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			AGCTACTCGAGGCTCTCTGAT	0.488000													15	35					0	0	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20616166	20616166	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr20:20616166C>T	uc002wrz.2	-	9	1044	c.901G>A	c.(901-903)GTT>ATT	p.V301I	RALGAPA2_uc010gcx.2_Missense_Mutation_p.V5I|RALGAPA2_uc010zsg.1_5'UTR	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	301					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						ATAAAAACAACACGAGCTGCC	0.358000													6	121					0	0	0	0
FRG1B	284802	broad.mit.edu	37	20	29625934	29625934	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr20:29625934C>T	uc010ztl.1	+	2	120	c.88C>T	c.(88-90)CAT>TAT	p.H30Y	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						ACTTGTTGGGCATTCAGATGC	0.338000													5	50					0	0	0	0
NECAB3	63941	broad.mit.edu	37	20	32247476	32247476	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr20:32247476C>T	uc002wzn.3	-	8	812	c.706G>A	c.(706-708)GAC>AAC	p.D236N	NECAB3_uc002wzl.2_Missense_Mutation_p.D15N|NECAB3_uc002wzm.3_Missense_Mutation_p.D236N|NECAB3_uc002wzo.3_RNA|NECAB3_uc002wzp.3_Missense_Mutation_p.D187N|NECAB3_uc002wzq.3_Missense_Mutation_p.D236N|NECAB3_uc002wzr.3_RNA|NECAB3_uc010geo.2_Missense_Mutation_p.D236N|C20orf144_uc002wzs.1_5'Flank	NM_031232	NP_112509	Q96P71	NECA3_HUMAN	N-terminal EF-hand calcium binding protein 3	236					antibiotic biosynthetic process|protein metabolic process|protein secretion|regulation of amyloid precursor protein biosynthetic process	endoplasmic reticulum membrane|Golgi cis cisterna|nucleus	calcium ion binding|oxidoreductase activity|protein binding			lung(1)	1						TCGAGCTGGTCGATGAGCTCC	0.706000													4	9					0	0	0	0
CEP250	11190	broad.mit.edu	37	20	34078580	34078580	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr20:34078580C>T	uc002xcm.2	+	22	3375	c.2704C>T	c.(2704-2706)CAG>TAG	p.Q902*	CEP250_uc010zve.1_Nonsense_Mutation_p.Q270*	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	902	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GGAGGCCATCCAGGCCCAGAG	0.557000													9	77					0	0	0	0
KIAA1755	85449	broad.mit.edu	37	20	36869729	36869729	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr20:36869729G>A	uc002xhy.1	-	3	1076	c.804C>T	c.(802-804)AGC>AGT	p.S268S	KIAA1755_uc002xhz.1_Silent_p.S268S	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	268										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				CGAAGTCCTGGCTGACCACCT	0.572000													11	75					0	0	0	0
JPH2	57158	broad.mit.edu	37	20	42815270	42815270	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr20:42815270G>T	uc002xli.1	-	1	949	c.76C>A	c.(76-78)CAT>AAT	p.H26N	JPH2_uc002xlj.2_Missense_Mutation_p.H26N	NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	26	MORN 1.|Gly-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CACAGTCCATGCCCATGGGCC	0.622000													8	43					2.17888e-05	8.18987e-05	1	0
C21orf99	149992	broad.mit.edu	37	21	14414902	14414902	+	RNA	SNP	G	A	A	rs2821609	by1000genomes	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr21:14414902G>A	uc002yiy.3	+	2		c.339G>A			C21orf99_uc002yja.3_RNA					Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						CCAGCTTGACGTCCTTGATGG	0.443000													11	38					0	0	0	0
KRTAP19-7	337974	broad.mit.edu	37	21	31933565	31933565	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr21:31933565C>T	uc011adb.1	-	1	44	c.44G>A	c.(43-45)TGT>TAT	p.C15Y		NM_181614	NP_853645	Q3SYF9	KR197_HUMAN	keratin associated protein 19-7	15						intermediate filament					0						GAATCCTCCACAGCCGTAGCC	0.552000													23	75					0	0	0	0
CECR2	27443	broad.mit.edu	37	22	18031816	18031816	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr22:18031816C>T	uc010gqw.1	+	17	4438	c.4312C>T	c.(4312-4314)CCC>TCC	p.P1438S	CECR2_uc010gqv.1_Missense_Mutation_p.P1296S|CECR2_uc002zml.2_Missense_Mutation_p.P1297S|CECR2_uc002zmo.2_RNA	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	1480					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		TCCAACACTTCCCCTGGATCA	0.498000													12	32					0	0	0	0
PIWIL3	440822	broad.mit.edu	37	22	25131809	25131809	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr22:25131809G>A	uc003abd.1	-	13	1917	c.1500C>T	c.(1498-1500)CCC>CCT	p.P500P	PIWIL3_uc011ajx.1_Silent_p.P391P|PIWIL3_uc011ajy.1_Silent_p.P391P|PIWIL3_uc010gut.1_Silent_p.P500P	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	500					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						CATTAAGTAAGGGTAATTCTC	0.383000													39	103					0	0	0	0
CCDC117	150275	broad.mit.edu	37	22	29169754	29169754	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr22:29169754A>T	uc003aeb.2	+	2	403	c.227A>T	c.(226-228)GAG>GTG	p.E76V	CCDC117_uc011aki.1_Intron|CCDC117_uc011akj.1_Missense_Mutation_p.E76V|CCDC117_uc011akk.1_5'UTR	NM_173510	NP_775781	Q8IWD4	CC117_HUMAN	coiled-coil domain containing 117	76										breast(1)	1						CGAGAGGAGGAGGAGGATGAT	0.373000													9	11					0	0	0	0
TAB1	10454	broad.mit.edu	37	22	39772188	39772188	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr22:39772188T>G	uc003axr.2	+	2	2029	c.247T>G	c.(247-249)TCC>GCC	p.S83A	SYNGR1_uc003axo.3_Missense_Mutation_p.S157A|SYNGR1_uc003axp.3_Missense_Mutation_p.L123R|SYNGR1_uc003axq.3_Missense_Mutation_p.S157A|SYNGR1_uc003axs.3_Missense_Mutation_p.S158A	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	7					activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						CTCCTTTTTCTCCATCTTCAC	0.637000													35	51					0	0	0	0
CERK	64781	broad.mit.edu	37	22	47103761	47103761	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr22:47103761G>A	uc003bia.2	-	6	801	c.694C>T	c.(694-696)CGG>TGG	p.R232W	CERK_uc010hae.2_Missense_Mutation_p.R34W	NM_022766	NP_073603	Q8TCT0	CERK1_HUMAN	ceramide kinase	232	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			skin(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ATTCCAATCCGGAGGCTACTG	0.602000													16	109					0	0	0	0
MAPK11	5600	broad.mit.edu	37	22	50705870	50705870	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr22:50705870A>T	uc003bkr.2	-	4	405	c.347T>A	c.(346-348)ATC>AAC	p.I116N	MAPK11_uc010hax.2_5'UTR|MAPK11_uc011ars.1_RNA|MAPK11_uc010hay.1_RNA|MAPK11_uc011art.1_Missense_Mutation_p.H96Q|MAPK11_uc010haz.2_Missense_Mutation_p.I8N	NM_002751	NP_002742	Q15759	MK11_HUMAN	mitogen-activated protein kinase 11	116	Protein kinase.				activation of MAPK activity|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			lung(1)|breast(1)	2		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCACTTGACGATGTTGTTCAG	0.682000													9	12					0	0	0	0
ZNF385D	79750	broad.mit.edu	37	3	21706434	21706434	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:21706434G>T	uc003cce.2	-	2	517	c.109C>A	c.(109-111)CTT>ATT	p.L37I	ZNF385D_uc010hfb.1_Intron	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	37						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GGAAAGGGAAGAAATGGTTTA	0.512000													10	23					2.74318e-10	1.10413e-09	1	0
GLB1	2720	broad.mit.edu	37	3	33059966	33059966	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:33059966C>T	uc003cfi.1	-	13	1438	c.1321G>A	c.(1321-1323)GAT>AAT	p.D441N	GLB1_uc003cfh.1_Missense_Mutation_p.D411N|GLB1_uc003cfj.1_Missense_Mutation_p.D310N|GLB1_uc011axk.1_Missense_Mutation_p.D489N	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	441			D -> N (in GM1G1).		carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				TATGCTCGATCGTGGACTCCA	0.507000													16	70					0	0	0	0
ARPP21	10777	broad.mit.edu	37	3	35833960	35833960	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:35833960A>T	uc003cgb.2	+	19	2383	c.2119A>T	c.(2119-2121)AAC>TAC	p.N707Y	ARPP21_uc003cga.2_Missense_Mutation_p.N688Y|ARPP21_uc011axy.1_Missense_Mutation_p.N708Y|ARPP21_uc003cgf.2_Missense_Mutation_p.N543Y|ARPP21_uc003cgg.2_Missense_Mutation_p.N230Y	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	707	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						CGTGATAAATAACCAACAAGG	0.463000													33	61					0	0	0	0
EPM2AIP1	9852	broad.mit.edu	37	3	37033930	37033930	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:37033930G>A	uc003cgk.2	-	1	866	c.639C>T	c.(637-639)AAC>AAT	p.N213N	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	213						endoplasmic reticulum					0						GATGAGTCAGGTTGATTATGG	0.517000													6	97					0	0	0	0
CTNNB1	1499	broad.mit.edu	37	3	41267196	41267196	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:41267196C>T	uc010hia.1	+	7	936	c.780C>T	c.(778-780)CAC>CAT	p.H260H	CTNNB1_uc003ckp.2_Silent_p.H260H|CTNNB1_uc003ckq.2_Silent_p.H260H|CTNNB1_uc003ckr.2_Silent_p.H260H|CTNNB1_uc011azf.1_Silent_p.H253H|CTNNB1_uc011azg.1_Silent_p.H188H|uc010hib.1_5'Flank	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	260	ARM 3.			H->A: Abolishes or strongly reduces AXIN1 and AXIN2 binding. Strongly reduces phosphorylation and degradation; when associated with A-386 and A-383.	adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	CAACTCTCCACAACCTTTTAT	0.383000		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				54	37					0	0	0	0
CDCP1	64866	broad.mit.edu	37	3	45127378	45127378	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:45127378G>A	uc003com.2	-	9	2398	c.2263C>T	c.(2263-2265)CTG>TTG	p.L755L		NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	755	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TCTGGCTGCAGGAAGGAGCCG	0.577000													71	41					0	0	0	0
PBRM1	55193	broad.mit.edu	37	3	52637658	52637658	+	Silent	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:52637658A>G	uc003des.2	-	17	2670	c.2658T>C	c.(2656-2658)CTT>CTC	p.L886L	PBRM1_uc003dex.2_Intron|PBRM1_uc003deq.2_Silent_p.L886L|PBRM1_uc003der.2_Silent_p.L854L|PBRM1_uc003det.2_Silent_p.L901L|PBRM1_uc003deu.2_Silent_p.L901L|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Silent_p.L886L|PBRM1_uc010hmk.1_Silent_p.L886L|PBRM1_uc003dey.2_Silent_p.L886L|PBRM1_uc003dez.1_Silent_p.L886L|PBRM1_uc003dfb.1_Silent_p.L799L|PBRM1_uc003dfa.1_Silent_p.L232L	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	886					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CCGGTGAAAGAAGAATCTCTC	0.343000			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								9	29					0	0	0	0
FAM55C	91775	broad.mit.edu	37	3	101535734	101535734	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:101535734C>T	uc003dvn.2	+	7	1655	c.1018C>T	c.(1018-1020)CAG>TAG	p.Q340*	FAM55C_uc010hpn.2_Nonsense_Mutation_p.Q340*	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	340						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						TAAGATGCGTCAGTTTAATGA	0.393000													7	92					0	0	0	0
DZIP3	9666	broad.mit.edu	37	3	108353773	108353773	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:108353773G>T	uc003dxd.2	+	10	1294	c.872G>T	c.(871-873)TGC>TTC	p.C291F	DZIP3_uc003dxf.1_Missense_Mutation_p.C291F|DZIP3_uc011bhm.1_Intron|DZIP3_uc003dxe.1_Missense_Mutation_p.C291F|DZIP3_uc003dxg.1_Missense_Mutation_p.C14F	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	291					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CATAAAATTTGCTGGAAAAAG	0.264000													17	60					3.51602e-12	1.44531e-11	1	0
PLXND1	23129	broad.mit.edu	37	3	129303021	129303021	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:129303021G>A	uc003emx.2	-	7	2185	c.2085C>T	c.(2083-2085)GCC>GCT	p.A695A		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	695	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGGTGAAATTGGCCTTGACGA	0.597000													5	6					0	0	0	0
COL6A6	131873	broad.mit.edu	37	3	130380825	130380825	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:130380825G>T	uc010htl.2	+	34	6206	c.6175G>T	c.(6175-6177)GCT>TCT	p.A2059S	COL6A6_uc003eni.3_Missense_Mutation_p.A158S	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	2059	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AAATGGAGATGCTTTTATTGG	0.413000													14	42					3.27435e-08	1.29103e-07	1	0
MME	4311	broad.mit.edu	37	3	154834497	154834497	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:154834497C>G	uc010hvr.1	+	6	695	c.484C>G	c.(484-486)CCA>GCA	p.P162A	MME_uc003fab.1_Missense_Mutation_p.P162A|MME_uc003fac.1_Missense_Mutation_p.P162A|MME_uc003fad.1_Missense_Mutation_p.P162A|MME_uc003fae.1_Missense_Mutation_p.P162A	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	162	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CAAACTGTTACCAGACATATA	0.363000													7	45					0	0	0	0
SI	6476	broad.mit.edu	37	3	164727122	164727122	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:164727122G>T	uc003fei.2	-	35	4186	c.4124C>A	c.(4123-4125)GCC>GAC	p.A1375D		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1375	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AATTTCTCTGGCCCACCACTC	0.383000										HNSCC(35;0.089)			18	57					1.45105e-14	6.06803e-14	1	0
SLC2A2	6514	broad.mit.edu	37	3	170723243	170723243	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:170723243C>T	uc003fhe.1	-	7	1103	c.794G>A	c.(793-795)GGA>GAA	p.G265E	SLC2A2_uc003fhf.1_Missense_Mutation_p.G92E|SLC2A2_uc011bpu.1_Missense_Mutation_p.G138E	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	265	Cytoplasmic (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			ATCATCATATCCTCTGAGTCT	0.343000													26	58					0	0	0	0
GHSR	2693	broad.mit.edu	37	3	172165726	172165726	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:172165726C>T	uc003fib.1	-	1	478	c.478G>A	c.(478-480)GTG>ATG	p.V160M	GHSR_uc011bpv.1_Missense_Mutation_p.V160M	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	160	Cytoplasmic (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			ACCAGCTTCACCCGCCCCTTG	0.652000													6	53					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	rs104886003		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			17	62					0	0	0	0
ATP13A4	84239	broad.mit.edu	37	3	193156328	193156328	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr3:193156328C>G	uc003ftd.2	-	23	2716	c.2608G>C	c.(2608-2610)GCA>CCA	p.A870P	ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	870	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GCCACAGATGCCTCCTGCTCT	0.443000													25	30					0	0	0	0
LGI2	55203	broad.mit.edu	37	4	25013978	25013978	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr4:25013978G>A	uc003grf.2	-	7	898	c.799C>T	c.(799-801)CGG>TGG	p.R267W		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	267	EAR 2.					extracellular region					0		Breast(46;0.173)				TCATAGCTCCGGAAATTCATT	0.507000													7	103					0	0	0	0
SULT1B1	27284	broad.mit.edu	37	4	70620403	70620403	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr4:70620403C>A	uc003hen.2	-	3	560	c.262G>T	c.(262-264)GGA>TGA	p.G88*		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	88					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						GTTCTTAATCCAGGGAGAGTC	0.299000													28	70					9.65021e-13	4.01815e-12	1	0
PTPN13	5783	broad.mit.edu	37	4	87703369	87703369	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr4:87703369G>A	uc003hpz.2	+	37	6458	c.5978G>A	c.(5977-5979)GGG>GAG	p.G1993E	PTPN13_uc003hpy.2_Missense_Mutation_p.G1998E|PTPN13_uc003hqa.2_Missense_Mutation_p.G1974E|PTPN13_uc003hqb.2_Missense_Mutation_p.G1802E|PTPN13_uc003hqc.1_Missense_Mutation_p.G359E	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1993						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TACAGTGTGGGGTCTTGCAGC	0.443000													9	85					0	0	0	0
HSPA4L	22824	broad.mit.edu	37	4	128732697	128732697	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr4:128732697C>T	uc003ifm.2	+	12	1737	c.1484C>T	c.(1483-1485)GCA>GTA	p.A495V	HSPA4L_uc010iny.1_Missense_Mutation_p.A454V|HSPA4L_uc011cgr.1_Missense_Mutation_p.A462V	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	495					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GTGGCTAGCGCATCAGTAATT	0.368000													8	26					0	0	0	0
NAA15	80155	broad.mit.edu	37	4	140309172	140309172	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr4:140309172G>A	uc003ihu.1	+	20	2791	c.2535G>A	c.(2533-2535)GAG>GAA	p.E845E		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	845					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						GATATGAAGAGGATATGAAGA	0.388000													13	25					0	0	0	0
PDGFC	56034	broad.mit.edu	37	4	157689065	157689065	+	Missense_Mutation	SNP	C	T	T	rs141820181		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr4:157689065C>T	uc003iph.1	-	5	1272	c.781G>A	c.(781-783)GAA>AAA	p.E261K	PDGFC_uc003ipi.1_Missense_Mutation_p.E98K|PDGFC_uc011cis.1_Missense_Mutation_p.E98K|PDGFC_uc011cir.1_Missense_Mutation_p.E105K	NM_016205	NP_057289	Q9NRA1	PDGFC_HUMAN	platelet-derived growth factor C precursor	261					central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity	p.E261K(1)		ovary(1)|lung(1)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		TTTAGTTCTTCCCTTATGGAC	0.438000													38	90					0	0	0	0
ODZ3	55714	broad.mit.edu	37	4	183601503	183601503	+	Splice_Site	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr4:183601503G>A	uc003ivd.1	+	8	1676	c.1639_splice	c.e8+1	p.A547_splice	ODZ3_uc003ive.1_Splice_Site	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3						signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TGTTCAAGAGGTATGCAAGTT	0.443000													8	19					0	0	0	0
ING2	3622	broad.mit.edu	37	4	184432021	184432021	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr4:184432021G>C	uc003ivs.1	+	2	888	c.759G>C	c.(757-759)TGG>TGC	p.W253C	ING2_uc011ckk.1_Missense_Mutation_p.W213C	NM_001564	NP_001555	Q9H160	ING2_HUMAN	inhibitor of growth family, member 2	253	PHD-type.				chromatin modification|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of growth|signal transduction|transcription, DNA-dependent	CCAAT-binding factor complex|Sin3 complex	chromatin binding|DNA binding|protein complex binding|zinc ion binding	p.W253C(1)		ovary(1)	1		all_lung(41;5.16e-14)|Lung NSC(41;1.33e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|all_hematologic(60;0.0207)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		AGGGGAAATGGTATTGCCCAA	0.388000													4	30					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187557355	187557355	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr4:187557355G>C	uc003izf.2	-	6	4195	c.4007C>G	c.(4006-4008)TCA>TGA	p.S1336*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1336	Extracellular (Potential).|Cadherin 11.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GGTGGTTGATGACTTTTGAGG	0.418000										HNSCC(5;0.00058)			15	36					0	0	0	0
TUBB4Q	56604	broad.mit.edu	37	4	190904367	190904367	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr4:190904367C>G	uc011clg.1	-	4	616	c.613G>C	c.(613-615)GCG>CCG	p.A205P		NM_020040	NP_064424	Q99867	TBB4Q_HUMAN	tubulin, beta polypeptide 4, member Q	206					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;4.1e-31)|Epithelial(3;1.44e-30)|OV - Ovarian serous cystadenocarcinoma(60;2.03e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00839)|READ - Rectum adenocarcinoma(43;0.155)		TCATATAGCGCTTCGTTATCT	0.542000													5	67					0	0	0	0
CDH9	1007	broad.mit.edu	37	5	26903930	26903930	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:26903930G>A	uc003jgs.1	-	6	984	c.815C>T	c.(814-816)ACG>ATG	p.T272M	CDH9_uc010iug.2_Missense_Mutation_p.T272M	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	272	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						AAATTGATACGTACCTATAAA	0.318000													7	28					0	0	0	0
NAIP	4671	broad.mit.edu	37	5	70308342	70308342	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:70308342T>C	uc003kar.1	-	4	1119	c.401A>G	c.(400-402)AAC>AGC	p.N134S	NAIP_uc003kat.1_Intron|NAIP_uc011crs.1_Missense_Mutation_p.N134S|NAIP_uc003kas.1_Intron	NM_004536	NP_004527	Q13075	BIRC1_HUMAN	NLR family, apoptosis inhibitory protein isoform	134					anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		CTTGGCAATGTTACCAACATC	0.488000													36	126					0	0	0	0
NSA2	10412	broad.mit.edu	37	5	74064792	74064792	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:74064792T>A	uc003kdk.1	+	2	123	c.40T>A	c.(40-42)TAT>AAT	p.Y14N	GFM2_uc003kdh.1_5'Flank|GFM2_uc003kdi.1_5'Flank|GFM2_uc010izj.1_5'Flank|GFM2_uc010izk.1_5'Flank|GFM2_uc003kdj.1_5'Flank|GFM2_uc010izl.1_5'Flank	NM_014886	NP_055701	O95478	NSA2_HUMAN	NSA2 ribosome biogenesis homolog	14					rRNA processing	nucleolus|ribonucleoprotein complex				ovary(1)	1						CCGTAAACGCTATGGATACCG	0.328000													5	9					0	0	0	0
LIX1	167410	broad.mit.edu	37	5	96478236	96478236	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:96478236G>A	uc003kmy.3	-	1	285	c.45C>T	c.(43-45)GTC>GTT	p.V15V		NM_153234	NP_694966	Q8N485	LIX1_HUMAN	limb expression 1	15										ovary(1)	1		all_cancers(142;4.28e-07)|all_epithelial(76;1.06e-09)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0318)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.0733)		TGTGAGGCAAGACTTGGGCAA	0.453000													6	55					0	0	0	0
PGGT1B	5229	broad.mit.edu	37	5	114588910	114588910	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:114588910C>T	uc003kqw.3	-	2	204	c.183G>A	c.(181-183)TTG>TTA	p.L61L	PGGT1B_uc003kqx.3_5'UTR|PGGT1B_uc010jch.2_Silent_p.L61L	NM_005023	NP_005014	P53609	PGTB1_HUMAN	geranylgeranyltransferase type 1 beta	61					protein geranylgeranylation	CAAX-protein geranylgeranyltransferase complex	CAAX-protein geranylgeranyltransferase activity				0		all_cancers(142;0.000523)|all_epithelial(76;6.45e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		Epithelial(69;2.95e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.98e-08)|all cancers(49;3.1e-06)	Pravastatin(DB00175)	CTAAGGAATCCAACATATCCA	0.363000													11	50					0	0	0	0
ZNF608	57507	broad.mit.edu	37	5	123983042	123983042	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:123983042C>A	uc003ktq.1	-	4	3158	c.3035G>T	c.(3034-3036)GGG>GTG	p.G1012V	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Missense_Mutation_p.G1012V|ZNF608_uc003ktt.1_Missense_Mutation_p.G1012V|ZNF608_uc003ktp.1_5'Flank	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1012						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		ACCGACCTGCCCAGGGTGCAT	0.473000													46	94					8.20599e-20	3.58687e-19	1	0
SLC27A6	28965	broad.mit.edu	37	5	128351596	128351596	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:128351596C>A	uc003kuy.2	+	6	1384	c.988C>A	c.(988-990)CAT>AAT	p.H330N	SLC27A6_uc003kuz.2_Missense_Mutation_p.H330N	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	330					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		AGAAAAGGATCATAAGGTGCG	0.308000													11	30					3.86212e-05	0.000142943	1	0
IL4	3565	broad.mit.edu	37	5	132015436	132015436	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:132015436G>A	uc003kxk.1	+	3	584	c.214G>A	c.(214-216)GCT>ACT	p.A72T	IL4_uc003kxl.1_Missense_Mutation_p.A56T	NM_000589	NP_000580	P05112	IL4_HUMAN	interleukin 4 isoform 1 precursor	72					B cell differentiation|cellular defense response|chemotaxis|cholesterol metabolic process|connective tissue growth factor biosynthetic process|negative regulation of apoptosis|negative regulation of osteoclast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of interleukin-13 production|positive regulation of isotype switching to IgE isotypes|positive regulation of isotype switching to IgG isotypes|positive regulation of MHC class II biosynthetic process|positive regulation of T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|T-helper 2 cell cytokine production	extracellular space	cytokine activity|growth factor activity|interleukin-4 receptor binding				0		all_cancers(142;2.81e-05)|all_lung(232;1.47e-05)|Lung NSC(810;2.31e-05)|all_neural(839;0.0459)|Ovarian(839;0.0481)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.00245)		CTTCTGCAGGGCTGCGACTGT	0.542000													63	124					0	0	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202653	140202653	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:140202653G>A	uc003lhl.2	+	1	1293	c.1293G>A	c.(1291-1293)TCG>TCA	p.S431S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.S431S|PCDHA5_uc003lhj.1_Silent_p.S431S	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	431	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGGGGGCTCGCCTTCGCTGT	0.647000													12	150					0	0	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222342	140222342	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:140222342C>T	uc003lhs.2	+	1	1436	c.1436C>T	c.(1435-1437)GCG>GTG	p.A479V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.A479V	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	479	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGGTGTCTGCGCGAGACGCG	0.657000													32	18					0	0	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262926	140262926	+	Missense_Mutation	SNP	C	T	T	rs144000682	byFrequency	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:140262926C>T	uc003lif.2	+	1	1073	c.1073C>T	c.(1072-1074)CCC>CTC	p.P358L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.P358L|PCDHA13_uc003lid.2_Missense_Mutation_p.P358L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	358	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTCACTCCCCATCAGAGAA	0.488000													23	57					0	0	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731974	140731974	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:140731974G>T	uc003ljo.1	+	1	2147	c.2147G>T	c.(2146-2148)AGC>ATC	p.S716I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGA4_uc003ljq.1_5'Flank|PCDHGB1_uc011daq.1_Missense_Mutation_p.S716I|PCDHGA4_uc003ljp.1_5'Flank	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	716	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTTCCTCCAGCCTCGACACT	0.582000													15	147					1.52009e-12	6.27525e-12	1	0
FAM71B	153745	broad.mit.edu	37	5	156590090	156590090	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:156590090C>G	uc003lwn.2	-	2	1286	c.1186G>C	c.(1186-1188)GGA>CGA	p.G396R		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	396						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATGAGGGGTCCCACTGCTGGT	0.537000													25	34					0	0	0	0
GABRA6	2559	broad.mit.edu	37	5	161128536	161128536	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:161128536G>A	uc003lyu.2	+	9	1457	c.1119G>A	c.(1117-1119)AGG>AGA	p.R373R	GABRA6_uc003lyv.2_Silent_p.R144R	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	373	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGAAGAAAAGGATCACTTCTC	0.398000										TCGA Ovarian(5;0.080)			22	62					0	0	0	0
FGFR4	2264	broad.mit.edu	37	5	176517973	176517973	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:176517973G>C	uc003mfl.2	+	5	638	c.471G>C	c.(469-471)AAG>AAC	p.K157N	FGFR4_uc003mfm.2_Missense_Mutation_p.K157N|FGFR4_uc011dfu.1_Missense_Mutation_p.K157N|FGFR4_uc011dfv.1_RNA|FGFR4_uc003mfn.1_3'UTR|FGFR4_uc011dfw.1_Missense_Mutation_p.K157N|FGFR4_uc003mfo.2_Missense_Mutation_p.K157N	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	157	Extracellular (Potential).|Ig-like C2-type 2.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GCATGGAGAAGAAACTGCATG	0.612000										TSP Lung(9;0.080)			5	48					0	0	0	0
NSD1	64324	broad.mit.edu	37	5	176665392	176665392	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:176665392C>A	uc003mfr.3	+	7	4214	c.4076C>A	c.(4075-4077)TCA>TAA	p.S1359*	NSD1_uc003mft.3_Nonsense_Mutation_p.S1090*|NSD1_uc003mfs.1_Nonsense_Mutation_p.S1256*|NSD1_uc011dfx.1_Nonsense_Mutation_p.S1007*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1359					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TTGGCTCAGTCAGAACTTGGA	0.542000			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			78	34					1.03218e-28	4.55292e-28	1	0
N4BP3	23138	broad.mit.edu	37	5	177548532	177548532	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:177548532G>A	uc003mik.1	+	5	1412	c.1165G>A	c.(1165-1167)GCG>ACG	p.A389T	N4BP3_uc003mil.1_Missense_Mutation_p.A58T	NM_015111	NP_055926	O15049	N4BP3_HUMAN	Nedd4 binding protein 3	389	Potential.					cytoplasmic vesicle membrane					0	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGAAGCCCAGGCGGAACTGGC	0.622000													47	90					0	0	0	0
HIST1H2BG	8339	broad.mit.edu	37	6	26216840	26216840	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr6:26216840G>C	uc003ngz.2	-	1	33	c.32C>G	c.(31-33)CCG>CGG	p.P11R	HIST1H2AE_uc003nha.1_5'Flank	NM_003518	NP_003509	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	11					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				ACCCTTCTTCGGAGCAGGAGC	0.493000													10	113					0	0	0	0
CDSN	1041	broad.mit.edu	37	6	31084822	31084822	+	Silent	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr6:31084822G>T	uc003nsm.1	-	2	597	c.570C>A	c.(568-570)TCC>TCA	p.S190S	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron	NM_001264	NP_001255	Q15517	CDSN_HUMAN	corneodesmosin precursor	190	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			ovary(1)|pancreas(1)	2						GTCCAGGCTGGGAAGGGTTTA	0.557000													38	36					3.62531e-18	1.54958e-17	1	0
HSP90AB1	3326	broad.mit.edu	37	6	44217289	44217289	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr6:44217289C>T	uc003oxa.1	+	3	407	c.323C>T	c.(322-324)TCT>TTT	p.S108F	HSP90AB1_uc011dvr.1_Missense_Mutation_p.S108F|HSP90AB1_uc003oxb.1_Missense_Mutation_p.S108F|HSP90AB1_uc011dvs.1_5'UTR|HSP90AB1_uc003oxc.1_5'Flank	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	108					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ATTGCCAAGTCTGGTACTAAA	0.418000													9	59					0	0	0	0
TINAG	27283	broad.mit.edu	37	6	54245333	54245333	+	Silent	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr6:54245333A>T	uc003pcj.2	+	10	1406	c.1260A>T	c.(1258-1260)ACA>ACT	p.T420T	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	420					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			GATGGGGCACACTGAGAGGAG	0.358000													4	11					0	0	0	0
LMBRD1	55788	broad.mit.edu	37	6	70428852	70428852	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr6:70428852G>C	uc003pfa.2	-	8	873	c.758C>G	c.(757-759)TCA>TGA	p.S253*	LMBRD1_uc003pey.2_Nonsense_Mutation_p.S49*|LMBRD1_uc003pez.2_Nonsense_Mutation_p.S180*|LMBRD1_uc010kal.2_Nonsense_Mutation_p.S180*|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	253	Cytoplasmic (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						ACTCACTTTTGATTTAATCGT	0.353000													5	23					0	0	0	0
SENP6	26054	broad.mit.edu	37	6	76344481	76344481	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr6:76344481C>T	uc003pid.3	+	5	1031	c.412C>T	c.(412-414)CAT>TAT	p.H138Y	SENP6_uc003pie.3_Missense_Mutation_p.H138Y|SENP6_uc003pic.2_Missense_Mutation_p.H138Y|SENP6_uc003pif.1_Missense_Mutation_p.H29Y	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	138					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				TAGACGTTTTCATCATGCTCA	0.353000													14	32					0	0	0	0
MDN1	23195	broad.mit.edu	37	6	90384310	90384310	+	Splice_Site	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr6:90384310T>C	uc003pnn.1	-	79	12878	c.12762_splice	c.e79-1	p.R4254_splice		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog						protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGGAGGTTCCTGTACAGAGAA	0.507000													13	32					0	0	0	0
FUT9	10690	broad.mit.edu	37	6	96651512	96651512	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr6:96651512G>T	uc003pop.3	+	3	822	c.481G>T	c.(481-483)GAT>TAT	p.D161Y		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	161	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		TTACCGCCGTGATTCAGATAT	0.453000													19	35					1.1804e-14	4.95766e-14	1	0
FAM184A	79632	broad.mit.edu	37	6	119338093	119338093	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr6:119338093T>C	uc003pyj.2	-	5	1697	c.1349A>G	c.(1348-1350)AAG>AGG	p.K450R	FAM184A_uc003pyk.3_Missense_Mutation_p.K330R|FAM184A_uc003pyl.3_Missense_Mutation_p.K330R	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	450	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						CTGAGTTCTCTTTGCTTCATT	0.333000													11	35					0	0	0	0
KIAA1244	57221	broad.mit.edu	37	6	138566721	138566721	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr6:138566721G>T	uc003qhu.2	+	8	658	c.658G>T	c.(658-660)GCC>TCC	p.A220S		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	220					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GCTGCAAGCCGCCATAAAGTA	0.453000													5	14					1.23904e-05	4.69378e-05	1	0
SYNE1	23345	broad.mit.edu	37	6	152462343	152462343	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr6:152462343G>A	uc010kiw.2	-	139	25843	c.25241C>T	c.(25240-25242)ACG>ATG	p.T8414M	SYNE1_uc010kiv.2_Missense_Mutation_p.T2938M|SYNE1_uc003qos.3_Missense_Mutation_p.T2938M|SYNE1_uc003qot.3_Missense_Mutation_p.T8366M|SYNE1_uc003qou.3_Missense_Mutation_p.T8414M|SYNE1_uc003qop.3_Missense_Mutation_p.T599M|SYNE1_uc011eez.1_Missense_Mutation_p.T616M|SYNE1_uc003qoq.3_Missense_Mutation_p.T616M|SYNE1_uc003qor.3_Missense_Mutation_p.T1337M	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8414	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCACCAGCCGTTTGGGTTTC	0.478000										HNSCC(10;0.0054)			28	60					0	0	0	0
TIAM2	26230	broad.mit.edu	37	6	155458488	155458488	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr6:155458488A>G	uc003qqb.2	+	7	2645	c.1372A>G	c.(1372-1374)ATT>GTT	p.I458V	TIAM2_uc003qqe.2_Missense_Mutation_p.I458V|TIAM2_uc010kjj.2_5'UTR	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	458					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CCGGCAGAACATTTATGAGAA	0.507000													38	76					0	0	0	0
PLG	5340	broad.mit.edu	37	6	161159606	161159606	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr6:161159606C>T	uc003qtm.3	+	15	1902	c.1839C>T	c.(1837-1839)TCC>TCT	p.S613S		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	613	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CCTTGATATCCCCAGAGTGGG	0.373000													30	60					0	0	0	0
SDK1	221935	broad.mit.edu	37	7	4185403	4185403	+	Silent	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr7:4185403C>A	uc003smx.2	+	29	4417	c.4278C>A	c.(4276-4278)ACC>ACA	p.T1426T	SDK1_uc010kso.2_Silent_p.T702T|SDK1_uc003smy.2_5'UTR	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1426	Fibronectin type-III 8.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACACCTTCACCACCGTGGAGG	0.657000													9	60					1.76689e-08	6.99516e-08	1	0
SCIN	85477	broad.mit.edu	37	7	12675756	12675756	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr7:12675756T>C	uc003ssn.3	+	10	1616	c.1406T>C	c.(1405-1407)GTG>GCG	p.V469A	SCIN_uc010ktt.2_RNA|SCIN_uc003sso.3_Missense_Mutation_p.V222A	NM_001112706	NP_001106177	Q9Y6U3	ADSV_HUMAN	scinderin isoform 1	469	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		GGACAGGCTGTGCAGGTTGGG	0.468000													4	8					0	0	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31124410	31124410	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr7:31124410T>A	uc003tca.1	+	8	720	c.497T>A	c.(496-498)GTC>GAC	p.V166D	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.V145D|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.V166D|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.V166D|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.V166D|ADCYAP1R1_uc003tcf.1_5'Flank	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	166	Helical; Name=1; (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity	p.V166fs*25(1)		ovary(1)	1						ACATCCCTCGTCACCCTCACC	0.557000													30	79					0	0	0	0
GRB10	2887	broad.mit.edu	37	7	50682481	50682481	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr7:50682481C>A	uc003tpi.2	-	9	1112	c.1081G>T	c.(1081-1083)GGG>TGG	p.G361W	GRB10_uc003tph.3_Missense_Mutation_p.G303W|GRB10_uc003tpj.2_Missense_Mutation_p.G315W|GRB10_uc003tpk.2_Missense_Mutation_p.G361W|GRB10_uc010kzb.2_Missense_Mutation_p.G303W|GRB10_uc003tpl.2_Missense_Mutation_p.G355W|GRB10_uc003tpm.2_Missense_Mutation_p.G303W|GRB10_uc003tpn.2_Missense_Mutation_p.G303W	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	361	PH.				insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					ATGCAGAGCCCGTGGTCTGTA	0.587000									Russell-Silver_syndrome				31	68					8.16721e-17	3.44521e-16	1	0
EGFR	1956	broad.mit.edu	37	7	55220295	55220295	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr7:55220295A>T	uc003tqk.2	+	6	931	c.685A>T	c.(685-687)AGT>TGT	p.S229C	EGFR_uc003tqh.2_Missense_Mutation_p.S229C|EGFR_uc003tqi.2_Missense_Mutation_p.S229C|EGFR_uc003tqj.2_Missense_Mutation_p.S229C|EGFR_uc010kzg.1_Missense_Mutation_p.S184C|EGFR_uc011kco.1_Missense_Mutation_p.S176C|EGFR_uc003tql.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	229	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAAGTCCCCCAGTGACTGCTG	0.617000		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			56	85					0	0	0	0
GRM3	2913	broad.mit.edu	37	7	86394583	86394583	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr7:86394583T>C	uc003uid.2	+	2	1221	c.122T>C	c.(121-123)TTA>TCA	p.L41S	GRM3_uc010lef.2_Missense_Mutation_p.L39S|GRM3_uc010leg.2_Intron|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	41	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GACCTTGTTTTAGGGGGCCTG	0.413000													23	48					0	0	0	0
PON2	5445	broad.mit.edu	37	7	95039308	95039308	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr7:95039308G>A	uc003unv.2	-	6	721	c.600C>T	c.(598-600)CAC>CAT	p.H200H	PON2_uc003unu.2_Silent_p.H188H|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_Silent_p.H113H	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	200					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			CATTTGCCCAGTGTAAGTTCA	0.373000													23	54					0	0	0	0
TMEM168	64418	broad.mit.edu	37	7	112407741	112407741	+	Silent	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr7:112407741G>C	uc003vgn.2	-	5	1997	c.1605C>G	c.(1603-1605)TCC>TCG	p.S535S	TMEM168_uc010lju.2_Silent_p.S535S|TMEM168_uc011kmr.1_Silent_p.S151S	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	535						integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						GGGAACAAAAGGAACCATTCT	0.403000													17	41					0	0	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518983	113518983	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr7:113518983T>C	uc010ljy.1	-	4	2195	c.2164A>G	c.(2164-2166)ACT>GCT	p.T722A		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	722					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						GCTTTCTCAGTAATGCCATGA	0.388000													3	139					0	0	0	0
DPP6	1804	broad.mit.edu	37	7	154172062	154172062	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr7:154172062G>C	uc003wlk.2	+	3	526	c.397G>C	c.(397-399)GTA>CTA	p.V133L	DPP6_uc003wli.2_Missense_Mutation_p.V69L|DPP6_uc003wlj.2_Missense_Mutation_p.V133L|DPP6_uc010lqh.1_Missense_Mutation_p.V71L|DPP6_uc003wlm.2_Missense_Mutation_p.V71L|DPP6_uc011kvq.1_Missense_Mutation_p.V71L	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	133	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GAAGGTCACTGTAGAAGATCT	0.403000													39	44					0	0	0	0
NCAPG2	54892	broad.mit.edu	37	7	158449250	158449250	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr7:158449250C>T	uc003wnv.1	-	18	2353	c.2208G>A	c.(2206-2208)CAG>CAA	p.Q736Q	NCAPG2_uc010lqu.1_Silent_p.Q528Q|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Silent_p.Q736Q|NCAPG2_uc011kwe.1_Silent_p.Q736Q|NCAPG2_uc011kwc.1_Silent_p.Q237Q|NCAPG2_uc011kwd.1_Silent_p.Q179Q	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	736					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		CTACCTTGGCCTGGGCATGCT	0.468000													7	55					0	0	0	0
MTUS1	57509	broad.mit.edu	37	8	17611496	17611496	+	Silent	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr8:17611496G>C	uc003wxv.2	-	2	2295	c.1821C>G	c.(1819-1821)GCC>GCG	p.A607A	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Silent_p.A607A|MTUS1_uc010lsz.2_Silent_p.A607A	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	607						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		TCGATTTCACGGCAGATGTTG	0.433000													5	167					0	0	0	0
JPH1	56704	broad.mit.edu	37	8	75227563	75227563	+	Silent	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr8:75227563G>C	uc003yae.2	-	2	712	c.672C>G	c.(670-672)CGC>CGG	p.R224R	JPH1_uc003yaf.2_Silent_p.R224R|JPH1_uc003yag.1_Silent_p.R88R	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	224	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			ATTCGGACTTGCGAAGTTTCA	0.582000													9	104					0	0	0	0
RSPO2	340419	broad.mit.edu	37	8	108970481	108970481	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr8:108970481C>A	uc003yms.2	-	5	1101	c.443G>T	c.(442-444)GGT>GTT	p.G148V	RSPO2_uc003ymq.2_Missense_Mutation_p.G81V|RSPO2_uc003ymr.2_Missense_Mutation_p.G84V	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	148	TSP type-1.				Wnt receptor signaling pathway	extracellular region	heparin binding	p.G148S(1)		skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			GCTCCAATGACCAACTTCACA	0.368000													20	41					1.50039e-11	6.11552e-11	1	0
CSMD3	114788	broad.mit.edu	37	8	113326782	113326782	+	Silent	SNP	A	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr8:113326782A>T	uc003ynu.2	-	48	7584	c.7425T>A	c.(7423-7425)CCT>CCA	p.P2475P	CSMD3_uc003yns.2_Silent_p.P1677P|CSMD3_uc003ynt.2_Silent_p.P2435P|CSMD3_uc011lhx.1_Silent_p.P2371P|CSMD3_uc003ynw.1_Silent_p.P186P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2475	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGTAACTGTCAGGATATCCAG	0.388000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	23					0	0	0	0
FAM83H	286077	broad.mit.edu	37	8	144808544	144808544	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr8:144808544G>A	uc003yzk.2	-	5	3156	c.3087C>T	c.(3085-3087)AAC>AAT	p.N1029N	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	1029					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TGTACAAGGCGTTGGCCGTGG	0.692000													5	10					0	0	0	0
PARP10	84875	broad.mit.edu	37	8	145060329	145060329	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr8:145060329C>T	uc003zal.3	-	2	183	c.75G>A	c.(73-75)GAG>GAA	p.E25E	PARP10_uc003zak.3_5'Flank|PARP10_uc011lku.1_Silent_p.E37E|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Silent_p.E25E|PARP10_uc010mfn.1_Silent_p.E25E|PARP10_uc010mfo.1_Intron	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	25						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GAGTGAGCAGCTCGTCGGGCA	0.657000													12	63					0	0	0	0
LRRC14	9684	broad.mit.edu	37	8	145746352	145746352	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr8:145746352G>A	uc003zdk.1	+	4	1118	c.972G>A	c.(970-972)GAG>GAA	p.E324E	LRRC14_uc003zdl.1_Silent_p.E324E|LRRC14_uc003zdo.2_5'Flank	NM_014665	NP_055480	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	324	LRR 2.										0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGCTGCCTGAGGACCTACGCT	0.637000													18	159					0	0	0	0
SMARCA2	6595	broad.mit.edu	37	9	2076291	2076291	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr9:2076291C>A	uc003zhc.2	+	13	2097	c.1998C>A	c.(1996-1998)AGC>AGA	p.S666R	SMARCA2_uc003zhd.2_Missense_Mutation_p.S666R|SMARCA2_uc010mha.2_Missense_Mutation_p.S657R	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	666					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ATCCAAATAGCGAAGAAGTTT	0.388000													27	51					1.88708e-17	7.99528e-17	1	0
TEK	7010	broad.mit.edu	37	9	27218815	27218815	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr9:27218815G>T	uc003zqi.3	+	20	3545	c.3103G>T	c.(3103-3105)GGA>TGA	p.G1035*	TEK_uc011lno.1_Nonsense_Mutation_p.G992*|TEK_uc011lnp.1_Nonsense_Mutation_p.G887*	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	1035	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TGTTAGCTTAGGTGAGTATCT	0.463000													13	32					6.72482e-11	2.71807e-10	1	0
CCIN	881	broad.mit.edu	37	9	36170744	36170744	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr9:36170744C>T	uc003zzb.3	+	1	1356	c.1245C>T	c.(1243-1245)GGC>GGT	p.G415G		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	415	Kelch 3.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			CCATGGATGGCACCGCCGTGA	0.542000													29	43					0	0	0	0
TLE4	7091	broad.mit.edu	37	9	82320843	82320843	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr9:82320843G>C	uc004ald.2	+	10	1597	c.748G>C	c.(748-750)GAC>CAC	p.D250H	TLE4_uc004alc.2_Missense_Mutation_p.D257H|TLE4_uc010mpr.2_Missense_Mutation_p.D136H|TLE4_uc004ale.2_5'UTR|TLE4_uc011lsq.1_Missense_Mutation_p.D225H|TLE4_uc010mps.2_Intron|TLE4_uc004alf.2_Missense_Mutation_p.D196H	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						CTTGGTGGTTGACGTTTCCAA	0.398000													6	80					0	0	0	0
GRIN3A	116443	broad.mit.edu	37	9	104449192	104449192	+	Silent	SNP	G	A	A	rs144389302		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr9:104449192G>A	uc004bbp.1	-	2	1591	c.990C>T	c.(988-990)TGC>TGT	p.C330C	GRIN3A_uc004bbq.1_Silent_p.C330C	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	330	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TTTCCATGTCGCAGCCAAACA	0.527000													11	26					0	0	0	0
SETX	23064	broad.mit.edu	37	9	135204921	135204921	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr9:135204921G>A	uc004cbk.2	-	10	2247	c.2064C>T	c.(2062-2064)TGC>TGT	p.C688C	SETX_uc004cbj.2_Silent_p.C307C|SETX_uc010mzt.2_Silent_p.C307C	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	688					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TCTGCTTTAAGCATGACCCAG	0.328000													25	43					0	0	0	0
RALGDS	5900	broad.mit.edu	37	9	136037789	136037789	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr9:136037789C>T	uc011mcw.1	-	2	292	c.11G>A	c.(10-12)CGG>CAG	p.R4Q	GBGT1_uc004ccx.2_5'UTR|GBGT1_uc010nab.2_Missense_Mutation_p.R4Q|GBGT1_uc011mcx.1_Missense_Mutation_p.R4Q|GBGT1_uc004ccw.2_Missense_Mutation_p.R4Q|GBGT1_uc010nac.1_5'UTR|GBGT1_uc004ccy.1_Missense_Mutation_p.R4Q	NM_001042368	NP_001035827	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	Error:Variant_position_missing_in_Q12967_after_alignment					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		GGCCAGTCTCCGGCGATGCAT	0.607000			T	CIITA	PMBL|Hodgkin Lymphona|								5	15					0	0	0	0
SURF4	6836	broad.mit.edu	37	9	136234223	136234223	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr9:136234223G>A	uc004cdj.2	-	2	277	c.147C>T	c.(145-147)AGC>AGT	p.S49S	SURF4_uc011mda.1_Silent_p.S40S|SURF4_uc010nal.2_Silent_p.S81S|SURF4_uc011mdb.1_Silent_p.S6S|SURF4_uc011mdc.1_Silent_p.S6S|SURF4_uc011mdd.1_Silent_p.S49S	NM_033161	NP_149351	O15260	SURF4_HUMAN	surfeit 4	49						endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.32e-07)|Epithelial(140;4.56e-06)|all cancers(34;4.25e-05)		CGCGCTGCTCGCTCCACTGGA	0.597000													22	25					0	0	0	0
FCN1	2219	broad.mit.edu	37	9	137809628	137809628	+	Silent	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr9:137809628C>T	uc004cfi.2	-	1	182	c.90G>A	c.(88-90)GCG>GCA	p.A30A		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	30					opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		GACATGTGTCCGCAGCCTGGG	0.572000													23	42					0	0	0	0
MAGEB18	286514	broad.mit.edu	37	X	26157205	26157205	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chrX:26157205G>A	uc004dbq.1	+	2	290	c.103G>A	c.(103-105)GGA>AGA	p.G35R		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	35							protein binding			central_nervous_system(1)	1						TGTGGCAGAAGGAGAGTCACC	0.587000													5	15					0	0	0	0
CASK	8573	broad.mit.edu	37	X	41390289	41390289	+	Silent	SNP	G	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chrX:41390289G>A	uc004dfl.3	-	25	2522	c.2476C>T	c.(2476-2478)CTG>TTG	p.L826L	CASK_uc004dfj.3_Silent_p.L371L|CASK_uc004dfk.3_Silent_p.L646L|CASK_uc004dfm.3_Silent_p.L803L|CASK_uc004dfn.3_Silent_p.L802L	NM_003688	NP_003679	O14936	CSKP_HUMAN	calcium/calmodulin-dependent serine protein	831	Guanylate kinase-like.				cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			ovary(3)|lung(2)|stomach(1)	6						ATTGCAATCAGCCCCTGCTCG	0.512000													28	12					0	0	0	0
TCEAL2	140597	broad.mit.edu	37	X	101382277	101382277	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chrX:101382277G>T	uc004eip.2	+	3	694	c.475G>T	c.(475-477)GAT>TAT	p.D159Y		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						AGCCATACATGATATGAATTT	0.428000													11	58					1.33987e-11	5.48438e-11	1	0
TEX13A	56157	broad.mit.edu	37	X	104464103	104464103	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chrX:104464103G>T	uc004ema.2	-	5	885	c.773C>A	c.(772-774)ACC>AAC	p.T258N	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Missense_Mutation_p.P259T	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	258						intracellular	zinc ion binding			ovary(2)	2						CCCCCAATAGGTGTACTTTTC	0.562000													15	5					1.15088e-07	4.46485e-07	1	0
GPR119	139760	broad.mit.edu	37	X	129518927	129518927	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chrX:129518927G>T	uc011muv.1	-	1	495	c.495C>A	c.(493-495)TTC>TTA	p.F165L		NM_178471	NP_848566	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	165	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	lipid binding			ovary(2)	2						GGGTCAGCACGAAGTGAGGGT	0.532000													21	13					2.54575e-18	1.09297e-17	1	0
FLNA	2316	broad.mit.edu	37	X	153588903	153588903	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chrX:153588903C>T	uc004fkk.2	-	22	3509	c.3260G>A	c.(3259-3261)CGC>CAC	p.R1087H	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Missense_Mutation_p.R1087H	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1087	Filamin 9.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GATGGTGAAGCGGGCGGGGGA	0.692000											OREG0003593	type=REGULATORY REGION|Gene=FLNA|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	5	14					0	0	0	0
TSPY1	7258	broad.mit.edu	37	Y	9305927	9305927	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chrY:9305927C>G	uc004frw.3	+	3	629	c.583C>G	c.(583-585)CCT>GCT	p.P195A	TSPY1_uc004frx.3_Missense_Mutation_p.P195A|TSPY1_uc010nwp.1_Intron	NM_003308	NP_003299	Q01534	TSPY1_HUMAN	testis specific protein, Y-linked 1	195			P -> R.		cell differentiation|cell proliferation|gonadal mesoderm development|nucleosome assembly|spermatogenesis	cytoplasm|nucleus	identical protein binding				0						AGAGAAGCATCCTGTTCATCT	0.443000													20	139					0	0	0	0
PRDM2	7799	broad.mit.edu	37	1	14107331	14107331	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:14107331delC	uc001avi.2	+	8	3897	c.3041delC	c.(3040-3042)GCCfs	p.A1014fs	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Frame_Shift_Del_p.A1014fs|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Frame_Shift_Del_p.A813fs|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1014	Pro-rich.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		CTCTCAAATGCCACCGCACAG	0.632													---	---	---							
CLSPN	63967	broad.mit.edu	37	1	36226310	36226311	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr1:36226310_36226311insT	uc001bzi.2	-	8	1291_1292	c.1211_1212insA	c.(1210-1212)AATfs	p.N404fs	CLSPN_uc009vux.2_Frame_Shift_Ins_p.N404fs	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	404					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTAGCTCTTCATTTTTTACCAA	0.436													---	---	---							
FBXO18	84893	broad.mit.edu	37	10	5958267	5958267	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:5958267delG	uc001iis.2	+	10	1731	c.1636delG	c.(1636-1638)GGGfs	p.G546fs	FBXO18_uc001iir.2_Frame_Shift_Del_p.G472fs|FBXO18_uc009xig.2_Frame_Shift_Del_p.G472fs|FBXO18_uc001iit.2_Frame_Shift_Del_p.G597fs	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	546					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						CCTTGCTGAAGGGAAGGGTGG	0.463													---	---	---							
KIAA1217	56243	broad.mit.edu	37	10	24825815	24825817	+	In_Frame_Del	DEL	AGA	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:24825815_24825817delAGA	uc001iru.3	+	17	3930_3932	c.3527_3529delAGA	c.(3526-3531)GAGAAG>GAG	p.K1178del	KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_In_Frame_Del_p.K1142del|KIAA1217_uc010qcz.1_In_Frame_Del_p.K1143del|KIAA1217_uc001irw.2_In_Frame_Del_p.K861del|KIAA1217_uc001irz.2_Intron|KIAA1217_uc001irx.2_In_Frame_Del_p.K861del|KIAA1217_uc001iry.2_In_Frame_Del_p.K861del	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1178					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						CCACCCAAGGAGAAGAAGGTAAC	0.517													---	---	---							
Unknown	0	broad.mit.edu	37	10	86535359	86535360	+	IGR	INS	-	TT	TT	rs138295367	by1000genomes	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr10:86535359_86535360insTT								FAM190B (257083 upstream) : GRID1 (823952 downstream)																							cgctctttttctttttcttttt	0.000													---	---	---							
NLRP14	338323	broad.mit.edu	37	11	7064303	7064303	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr11:7064303delC	uc001mfb.1	+	4	1369	c.1046delC	c.(1045-1047)GCCfs	p.A349fs		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	349	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AAGAGGTGGGCCATGAAAGTA	0.428													---	---	---							
ZMYM2	7750	broad.mit.edu	37	13	20641147	20641148	+	Frame_Shift_Del	DEL	GA	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:20641147_20641148delGA	uc001umr.2	+	21	3587_3588	c.3289_3290delGA	c.(3289-3291)GAGfs	p.E1097fs	ZMYM2_uc001ums.2_Frame_Shift_Del_p.E1097fs|ZMYM2_uc001umt.2_Frame_Shift_Del_p.E1097fs|ZMYM2_uc001umv.2_Frame_Shift_Del_p.E477fs|ZMYM2_uc001umw.2_Frame_Shift_Del_p.E550fs	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	1097					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		GGTATTAGATGAGTTAAAATCT	0.302													---	---	---							
TRPC4	7223	broad.mit.edu	37	13	38320520	38320520	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr13:38320520delG	uc001uws.2	-	3	686	c.451delC	c.(451-453)CATfs	p.H151fs	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Frame_Shift_Del_p.H151fs|TRPC4_uc010tey.1_Frame_Shift_Del_p.H151fs|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Frame_Shift_Del_p.H151fs|TRPC4_uc010aby.2_Frame_Shift_Del_p.H151fs	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	151	Cytoplasmic (Potential).|ANK 4.|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTATTTGTATGGGCTGCCAAA	0.433													---	---	---							
SLC12A6	9990	broad.mit.edu	37	15	34529660	34529661	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr15:34529660_34529661insA	uc001zhw.2	-	21	3057_3058	c.2893_2894insT	c.(2893-2895)TATfs	p.Y965fs	SLC12A6_uc001zhv.2_Frame_Shift_Ins_p.Y914fs|SLC12A6_uc001zhx.2_Frame_Shift_Ins_p.Y950fs|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Frame_Shift_Ins_p.Y906fs|SLC12A6_uc001zib.2_Frame_Shift_Ins_p.Y956fs|SLC12A6_uc001zic.2_Frame_Shift_Ins_p.Y965fs|SLC12A6_uc010bau.2_Frame_Shift_Ins_p.Y965fs|SLC12A6_uc001zid.2_Frame_Shift_Ins_p.Y906fs|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Frame_Shift_Ins_p.Y777fs	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	965	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	GCGTAAGTGATATAGGAAGGTG	0.480													---	---	---							
KRT9	3857	broad.mit.edu	37	17	39726431	39726440	+	Frame_Shift_Del	DEL	GTCCAGGAGA	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:39726431_39726440delGTCCAGGAGA	uc002hxe.3	-	2	741_750	c.675_684delTCTCCTGGAC	c.(673-684)ACTCTCCTGGACfs	p.T225fs	JUP_uc010wfs.1_Intron	NM_000226	NP_000217	P35527	K1C9_HUMAN	keratin 9	225_228	Rod.|Coil 1B.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Breast(137;0.000307)				TGTTGTCAATGTCCAGGAGAGTTTTGTTGT	0.510													---	---	---							
Unknown	0	broad.mit.edu	37	17	60214960	60214960	+	IGR	DEL	G	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:60214960delG								MED13 (72317 upstream) : TBC1D3P2 (127109 downstream)																							ACGAACTCCTGGGGAAAGTCG	0.617													---	---	---							
PGS1	9489	broad.mit.edu	37	17	76396892	76396892	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr17:76396892delA	uc002jvm.2	+	6	848	c.836delA	c.(835-837)GACfs	p.D279fs	PGS1_uc010wtt.1_RNA|PGS1_uc010dho.2_RNA|PGS1_uc002jvn.2_5'UTR|PGS1_uc002jvo.2_RNA|PGS1_uc002jvp.1_5'UTR	NM_024419	NP_077733	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	279					phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			CTGCAGGGGGACGACACGGTG	0.637													---	---	---							
THSD7B	80731	broad.mit.edu	37	2	138414509	138414510	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr2:138414509_138414510insA	uc002tva.1	+	22	4162_4163	c.4162_4163insA	c.(4162-4164)CAAfs	p.Q1388fs	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CAGCTGCCCCCAACAGGTTCTA	0.426													---	---	---							
NEK4	6787	broad.mit.edu	37	3	52778296	52778297	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr3:52778296_52778297delCT	uc003dfq.3	-	11	2041_2042	c.1852_1853delAG	c.(1852-1854)AGGfs	p.R618fs	NEK4_uc011bej.1_Frame_Shift_Del_p.R529fs|NEK4_uc003dfr.2_Frame_Shift_Del_p.R572fs	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	618					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		TAGTCGCCTCCTCTCTCTGGCT	0.406													---	---	---							
CDHR2	54825	broad.mit.edu	37	5	175995964	175995965	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:175995964_175995965delCT	uc003mem.1	+	5	334_335	c.268_269delCT	c.(268-270)CTCfs	p.L90fs	CDHR2_uc003men.1_Frame_Shift_Del_p.L90fs	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	90	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						GCTGCAGACACTCTACACATTC	0.644													---	---	---							
GRM6	2916	broad.mit.edu	37	5	178424905	178424905	+	5'Flank	DEL	C	-	-	rs148398858	by1000genomes	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:178424905delC	uc003mjr.2	-							NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor						detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		AGAGGTTGCACCCCAAAACCC	0.542													---	---	---							
MGAT4B	11282	broad.mit.edu	37	5	179228834	179228837	+	Frame_Shift_Del	DEL	CTTT	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr5:179228834_179228837delCTTT	uc003mks.2	-	2	599_602	c.230_233delAAAG	c.(229-234)GAAAGGfs	p.E77fs	MGAT4B_uc003mkp.2_5'Flank|MGAT4B_uc003mkq.2_5'UTR|MGAT4B_uc003mkr.2_Frame_Shift_Del_p.E92fs	NM_014275	NP_055090	Q9UQ53	MGT4B_HUMAN	alpha-1,3-mannosyl-glycoprotein	77_78	Potential.|Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding				0	all_cancers(89;0.000201)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0525)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGCGCCTGCCTTTCTGACACGGC	0.667											OREG0017110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---							
Unknown	0	broad.mit.edu	37	6	27179720	27179720	+	IGR	DEL	A	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr6:27179720delA								HIST1H2AH (64375 upstream) : PRSS16 (35788 downstream)																							CTTCCTGTCcaaaaaaaaaag	0.388													---	---	---							
Unknown	0	broad.mit.edu	37	7	62693694	62693694	+	IGR	DEL	C	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	b3f82016-0969-477c-8b02-18fb25524fd5	g.chr7:62693694delC								None (None upstream) : LOC643955 (57978 downstream)																							TGGGCTGCAGCCCCCGCCCTG	0.657													---	---	---							
PRDM2	7799	broad.mit.edu	37	1	14107331	14107331	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:14107331delC	uc001avi.2	+	8	3897	c.3041delC	c.(3040-3042)GCCfs	p.A1014fs	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Frame_Shift_Del_p.A1014fs|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Frame_Shift_Del_p.A813fs|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1014	Pro-rich.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		CTCTCAAATGCCACCGCACAG	0.632													---	---	---							
CLSPN	63967	broad.mit.edu	37	1	36226310	36226311	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:36226310_36226311insT	uc001bzi.2	-	8	1291_1292	c.1211_1212insA	c.(1210-1212)AATfs	p.N404fs	CLSPN_uc009vux.2_Frame_Shift_Ins_p.N404fs	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	404					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTAGCTCTTCATTTTTTACCAA	0.436													---	---	---							
ASH1L	55870	broad.mit.edu	37	1	155307999	155308000	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr1:155307999_155308000insT	uc009wqq.2	-	27	9178_9179	c.8698_8699insA	c.(8698-8700)ACAfs	p.T2900fs	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Frame_Shift_Ins_p.T2895fs	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2900					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			ACTTTCCTCTGTTTTTTTTTCA	0.520													---	---	---							
FBXO18	84893	broad.mit.edu	37	10	5958267	5958267	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr10:5958267delG	uc001iis.2	+	10	1731	c.1636delG	c.(1636-1638)GGGfs	p.G546fs	FBXO18_uc001iir.2_Frame_Shift_Del_p.G472fs|FBXO18_uc009xig.2_Frame_Shift_Del_p.G472fs|FBXO18_uc001iit.2_Frame_Shift_Del_p.G597fs	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	546					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						CCTTGCTGAAGGGAAGGGTGG	0.463													---	---	---							
KIAA1217	56243	broad.mit.edu	37	10	24825815	24825817	+	In_Frame_Del	DEL	AGA	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr10:24825815_24825817delAGA	uc001iru.3	+	17	3930_3932	c.3527_3529delAGA	c.(3526-3531)GAGAAG>GAG	p.K1178del	KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_In_Frame_Del_p.K1142del|KIAA1217_uc010qcz.1_In_Frame_Del_p.K1143del|KIAA1217_uc001irw.2_In_Frame_Del_p.K861del|KIAA1217_uc001irz.2_Intron|KIAA1217_uc001irx.2_In_Frame_Del_p.K861del|KIAA1217_uc001iry.2_In_Frame_Del_p.K861del	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1178					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						CCACCCAAGGAGAAGAAGGTAAC	0.517													---	---	---							
NLRP14	338323	broad.mit.edu	37	11	7064303	7064303	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr11:7064303delC	uc001mfb.1	+	4	1369	c.1046delC	c.(1045-1047)GCCfs	p.A349fs		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	349	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AAGAGGTGGGCCATGAAAGTA	0.428													---	---	---							
ZMYM2	7750	broad.mit.edu	37	13	20641147	20641148	+	Frame_Shift_Del	DEL	GA	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr13:20641147_20641148delGA	uc001umr.2	+	21	3587_3588	c.3289_3290delGA	c.(3289-3291)GAGfs	p.E1097fs	ZMYM2_uc001ums.2_Frame_Shift_Del_p.E1097fs|ZMYM2_uc001umt.2_Frame_Shift_Del_p.E1097fs|ZMYM2_uc001umv.2_Frame_Shift_Del_p.E477fs|ZMYM2_uc001umw.2_Frame_Shift_Del_p.E550fs	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	1097					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		GGTATTAGATGAGTTAAAATCT	0.302													---	---	---							
TRPC4	7223	broad.mit.edu	37	13	38320520	38320520	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr13:38320520delG	uc001uws.2	-	3	686	c.451delC	c.(451-453)CATfs	p.H151fs	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Frame_Shift_Del_p.H151fs|TRPC4_uc010tey.1_Frame_Shift_Del_p.H151fs|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Frame_Shift_Del_p.H151fs|TRPC4_uc010aby.2_Frame_Shift_Del_p.H151fs	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	151	Cytoplasmic (Potential).|ANK 4.|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTATTTGTATGGGCTGCCAAA	0.433													---	---	---							
SLC12A6	9990	broad.mit.edu	37	15	34529660	34529661	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr15:34529660_34529661insA	uc001zhw.2	-	21	3057_3058	c.2893_2894insT	c.(2893-2895)TATfs	p.Y965fs	SLC12A6_uc001zhv.2_Frame_Shift_Ins_p.Y914fs|SLC12A6_uc001zhx.2_Frame_Shift_Ins_p.Y950fs|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Frame_Shift_Ins_p.Y906fs|SLC12A6_uc001zib.2_Frame_Shift_Ins_p.Y956fs|SLC12A6_uc001zic.2_Frame_Shift_Ins_p.Y965fs|SLC12A6_uc010bau.2_Frame_Shift_Ins_p.Y965fs|SLC12A6_uc001zid.2_Frame_Shift_Ins_p.Y906fs|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Frame_Shift_Ins_p.Y777fs	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	965	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	GCGTAAGTGATATAGGAAGGTG	0.480													---	---	---							
Unknown	0	broad.mit.edu	37	16	89311096	89311097	+	IGR	INS	-	A	A	rs112232397		TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr16:89311096_89311097insA								ZNF778 (11596 upstream) : ANKRD11 (22938 downstream)																							gactcagtctcaaaaaaaaaag	0.277													---	---	---							
KRT9	3857	broad.mit.edu	37	17	39726431	39726440	+	Frame_Shift_Del	DEL	GTCCAGGAGA	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:39726431_39726440delGTCCAGGAGA	uc002hxe.3	-	2	741_750	c.675_684delTCTCCTGGAC	c.(673-684)ACTCTCCTGGACfs	p.T225fs	JUP_uc010wfs.1_Intron	NM_000226	NP_000217	P35527	K1C9_HUMAN	keratin 9	225_228	Rod.|Coil 1B.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Breast(137;0.000307)				TGTTGTCAATGTCCAGGAGAGTTTTGTTGT	0.510													---	---	---							
Unknown	0	broad.mit.edu	37	17	60214960	60214960	+	IGR	DEL	G	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:60214960delG								MED13 (72317 upstream) : TBC1D3P2 (127109 downstream)																							ACGAACTCCTGGGGAAAGTCG	0.617													---	---	---							
PGS1	9489	broad.mit.edu	37	17	76396892	76396892	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr17:76396892delA	uc002jvm.2	+	6	848	c.836delA	c.(835-837)GACfs	p.D279fs	PGS1_uc010wtt.1_RNA|PGS1_uc010dho.2_RNA|PGS1_uc002jvn.2_5'UTR|PGS1_uc002jvo.2_RNA|PGS1_uc002jvp.1_5'UTR	NM_024419	NP_077733	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	279					phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			CTGCAGGGGGACGACACGGTG	0.637													---	---	---							
THSD7B	80731	broad.mit.edu	37	2	138414509	138414510	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr2:138414509_138414510insA	uc002tva.1	+	22	4162_4163	c.4162_4163insA	c.(4162-4164)CAAfs	p.Q1388fs	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CAGCTGCCCCCAACAGGTTCTA	0.426													---	---	---							
FCHO2	115548	broad.mit.edu	37	5	72313079	72313086	+	Frame_Shift_Del	DEL	TTGAAAGT	-	-	rs143520046	by1000genomes	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:72313079_72313086delTTGAAAGT	uc003kcl.2	+	8	856_863	c.740_747delTTGAAAGT	c.(739-747)GTTGAAAGTfs	p.V247fs	FCHO2_uc011csl.1_Frame_Shift_Del_p.V214fs|FCHO2_uc011csk.1_Frame_Shift_Del_p.V247fs|FCHO2_uc011csm.1_Frame_Shift_Del_p.V53fs	NM_138782	NP_620137	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2 isoform a	247_249										ovary(1)	1		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		AATACTACAGTTGAAAGTTTGATACAAA	0.293													---	---	---							
CDHR2	54825	broad.mit.edu	37	5	175995964	175995965	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:175995964_175995965delCT	uc003mem.1	+	5	334_335	c.268_269delCT	c.(268-270)CTCfs	p.L90fs	CDHR2_uc003men.1_Frame_Shift_Del_p.L90fs	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	90	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						GCTGCAGACACTCTACACATTC	0.644													---	---	---							
GRM6	2916	broad.mit.edu	37	5	178424905	178424905	+	5'Flank	DEL	C	-	-	rs148398858	by1000genomes	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:178424905delC	uc003mjr.2	-							NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor						detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		AGAGGTTGCACCCCAAAACCC	0.542													---	---	---							
MGAT4B	11282	broad.mit.edu	37	5	179228834	179228837	+	Frame_Shift_Del	DEL	CTTT	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr5:179228834_179228837delCTTT	uc003mks.2	-	2	599_602	c.230_233delAAAG	c.(229-234)GAAAGGfs	p.E77fs	MGAT4B_uc003mkp.2_5'Flank|MGAT4B_uc003mkq.2_5'UTR|MGAT4B_uc003mkr.2_Frame_Shift_Del_p.E92fs	NM_014275	NP_055090	Q9UQ53	MGT4B_HUMAN	alpha-1,3-mannosyl-glycoprotein	77_78	Potential.|Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding				0	all_cancers(89;0.000201)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0525)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGCGCCTGCCTTTCTGACACGGC	0.667											OREG0017110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---							
WRNIP1	56897	broad.mit.edu	37	6	2766468	2766469	+	Frame_Shift_Ins	INS	-	GGGG	GGGG	rs148900120	by1000genomes	TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr6:2766468_2766469insGGGG	uc003mtz.2	+	1	803_804	c.612_613insGGGG	c.(610-615)GGCGGGfs	p.G204fs	WRNIP1_uc003mua.2_Frame_Shift_Ins_p.G204fs	NM_020135	NP_064520	Q96S55	WRIP1_HUMAN	Werner helicase interacting protein isoform 1	204_205					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA-dependent DNA replication initiation	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|DNA binding|metal ion binding|protein binding			ovary(1)|pancreas(1)	2	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				GGGCCAGTggcgggggccgccc	0.465													---	---	---							
Unknown	0	broad.mit.edu	37	7	62693694	62693694	+	IGR	DEL	C	-	-			TCGA-CV-7250-01A-11D-2012-08	TCGA-CV-7250-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	14516d2b-47dc-4768-977b-bc3c1fe93722	8ca57602-ec37-4f27-bd38-ad19da3997f2	g.chr7:62693694delC								None (None upstream) : LOC643955 (57978 downstream)																							TGGGCTGCAGCCCCCGCCCTG	0.657													---	---	---							
