Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
SLC35E2	9906	broad.mit.edu	37	1	1669760	1669760	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:1669760C>A	uc001aib.1	-	4	1002	c.586G>T	c.(586-588)GGA>TGA	p.G196*	SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Missense_Mutation_p.G196W|SLC35E2_uc001ahy.2_Nonsense_Mutation_p.G196*|SLC35E2_uc001ahz.2_Nonsense_Mutation_p.G196*	NM_182838	NP_878258	P0CK97	S35E2_HUMAN	solute carrier family 35, member E2	196						integral to membrane				pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGGGCCTCACCTGTGTACTCC	0.647		NaN											1	0	0.000602214	0.014758	0.000630224	4	11									
CAMTA1	23261	broad.mit.edu	37	1	7724195	7724195	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:7724195A>T	uc001aoi.2	+	9	1795	c.1588A>T	c.(1588-1590)AAG>TAG	p.K530*		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	530					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CGTCCTCACCAAGGAGATCAA	0.637		NaN											0	0	0	0.021553	0	5	59									
EIF4G3	8672	broad.mit.edu	37	1	21221934	21221934	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:21221934T>C	uc001bec.2	-	12	2148	c.1892A>G	c.(1891-1893)GAC>GGC	p.D631G	EIF4G3_uc010odi.1_Missense_Mutation_p.D235G|EIF4G3_uc010odj.1_Missense_Mutation_p.D630G|EIF4G3_uc009vpz.2_Missense_Mutation_p.D351G|EIF4G3_uc001bed.2_Missense_Mutation_p.D631G|EIF4G3_uc001bef.2_Missense_Mutation_p.D630G|EIF4G3_uc001bee.2_Missense_Mutation_p.D637G	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	631					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GAACTGGAAGTCCAGCAGAAA	0.463		NaN											0	0	0	0.004482	0	7	72									
EXTL1	2134	broad.mit.edu	37	1	26349162	26349162	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:26349162T>G	uc001blf.2	+	1	892	c.25T>G	c.(25-27)TCC>GCC	p.S9A		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	9	Cytoplasmic (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		GAGAAGAAAGTCCCTGTGGCT	0.667		NaN											0	0	0	0.009096	0	4	63									
IQCC	55721	broad.mit.edu	37	1	32673403	32673403	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:32673403T>A	uc001bum.2	+	5	1168	c.1121T>A	c.(1120-1122)TTG>TAG	p.L374*	IQCC_uc009vua.2_Nonsense_Mutation_p.L454*|IQCC_uc010ogz.1_Nonsense_Mutation_p.L274*|DCDC2B_uc001bun.2_5'Flank	NM_018134	NP_060604	Q4KMZ1	IQCC_HUMAN	IQ motif containing C isoform 2	374										ovary(4)	4		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ACACAAGAGTTGGGCCTCTCA	0.532		NaN											0	0	0	0.016723	0	13	120									
EIF3I	8668	broad.mit.edu	37	1	32690056	32690056	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:32690056G>C	uc001bur.3	+	5	763	c.230G>C	c.(229-231)CGT>CCT	p.R77P	C1orf91_uc001buo.3_5'Flank|C1orf91_uc001bup.3_5'Flank|C1orf91_uc009vub.1_5'Flank|C1orf91_uc010oha.1_5'Flank|C1orf91_uc001buq.3_5'Flank|EIF3I_uc009vuc.2_Missense_Mutation_p.R77P|EIF3I_uc001bus.2_Missense_Mutation_p.R29P	NM_003757	NP_003748	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3,	77	WD 2.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				AACAGCTGTCGTCTCTGGGAC	0.473		NaN											0	0	0	0.014758	0	4	50									
MAP7D1	55700	broad.mit.edu	37	1	36636690	36636690	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:36636690G>T	uc001bzz.2	+	2	381	c.165G>T	c.(163-165)ATG>ATT	p.M55I	MAP7D1_uc001caa.2_Missense_Mutation_p.M55I|MAP7D1_uc001cab.2_Missense_Mutation_p.M55I|MAP7D1_uc001cac.2_5'Flank	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	55	Pro-rich.					cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				CTCCTGCCATGAAGAATGCCA	0.652		NaN											1	0	2.74318e-10	0.006214	3.12514e-10	9	88									
KTI12	112970	broad.mit.edu	37	1	52499087	52499087	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:52499087C>T	uc001ctj.1	-	1	386	c.347G>A	c.(346-348)GGA>GAA	p.G116E	TXNDC12_uc001cti.2_Intron	NM_138417	NP_612426	Q96EK9	KTI12_HUMAN	KTI12 homolog, chromatin associated	116							ATP binding			central_nervous_system(2)	2						CACCTGAGGTCCCGCGATCGG	0.701		NaN											0	0	0	0.021553	0	5	65									
SCP2	6342	broad.mit.edu	37	1	53504595	53504595	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:53504595G>A	uc001cur.1	+	14	1466	c.1345G>A	c.(1345-1347)GAA>AAA	p.E449K	SCP2_uc001cus.1_RNA|SCP2_uc010ono.1_Missense_Mutation_p.E368K|SCP2_uc010onp.1_Missense_Mutation_p.E425K|SCP2_uc009vzi.1_Missense_Mutation_p.E405K|SCP2_uc010onq.1_Missense_Mutation_p.E45K|SCP2_uc001cut.1_Missense_Mutation_p.E42K|SCP2_uc001cuu.1_Intron	NM_002979	NP_002970	P22307	NLTP_HUMAN	sterol carrier protein 2 isoform 1 proprotein	449	SCP2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)	1						CCAGGAAGGGGAACAGTTTGT	0.423		NaN											0	0	0	0.010729	0	10	110									
C1orf146	388649	broad.mit.edu	37	1	92709803	92709803	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:92709803G>A	uc001doq.2	+	4	262	c.190G>A	c.(190-192)GAA>AAA	p.E64K	C1orf146_uc010ote.1_Missense_Mutation_p.E5K	NM_001012425	NP_001012425	Q5VVC0	CA146_HUMAN	hypothetical protein LOC388649	64										ovary(1)	1		all_lung(203;0.00528)|Lung NSC(277;0.0193)		all cancers(265;0.00846)|Epithelial(280;0.0952)		GGATACTAAGGAATGTCTTCT	0.299		NaN											0	0	0	0.021553	0	6	42									
NTNG1	22854	broad.mit.edu	37	1	107937933	107937933	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:107937933G>C	uc001dvh.3	+	4	1763	c.1045G>C	c.(1045-1047)GGC>CGC	p.G349R	NTNG1_uc001dvf.3_Missense_Mutation_p.G349R|NTNG1_uc010out.1_Missense_Mutation_p.G349R|NTNG1_uc001dvc.3_Missense_Mutation_p.G349R|NTNG1_uc001dvi.2_5'UTR|NTNG1_uc001dve.2_RNA|NTNG1_uc009wek.2_RNA|NTNG1_uc001dvg.2_RNA|NTNG1_uc009wem.2_Missense_Mutation_p.R21T|NTNG1_uc001dvd.1_Missense_Mutation_p.G349R	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	349	Laminin EGF-like 1.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CATCCCCAAAGGCACTGCAAA	0.453		NaN											0	0	0	0.02938	0	6	94									
STXBP3	6814	broad.mit.edu	37	1	109342863	109342863	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:109342863G>A	uc001dvy.2	+	17	1546	c.1471G>A	c.(1471-1473)GAT>AAT	p.D491N	STXBP3_uc001dvz.2_RNA	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3	491					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		TAATAGATTAGATTCAAAAGA	0.338		NaN											0	0	0	0.004482	0	9	42									
MAGI3	260425	broad.mit.edu	37	1	114201796	114201796	+	Silent	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:114201796G>C	uc001edk.2	+	16	2905	c.2724G>C	c.(2722-2724)GGG>GGC	p.G908G	MAGI3_uc001edh.3_Silent_p.G933G|MAGI3_uc001edi.3_Silent_p.G908G|MAGI3_uc010owm.1_Silent_p.G933G|MAGI3_uc001edj.2_Silent_p.G629G	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	933	Interaction with LPAR2 and GRIN2B.|PDZ 5.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGTGAATGGGCAGTCCATTG	0.453		NaN											0	0	0	0.008291	0	11	93									
SLC22A15	55356	broad.mit.edu	37	1	116569600	116569600	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:116569600A>G	uc001egb.3	+	5	815	c.685A>G	c.(685-687)ATT>GTT	p.I229V	SLC22A15_uc001ega.2_Missense_Mutation_p.I229V	NM_018420	NP_060890	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	229	Helical; (Potential).				ion transport	integral to membrane	transmembrane transporter activity			large_intestine(2)	2	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GACCCTAGCCATTCTGGTTAA	0.433		NaN											0	0	0	0.00308	0	8	105									
GATAD2B	57459	broad.mit.edu	37	1	153792155	153792155	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:153792155T>C	uc001fdb.3	-	3	636	c.392A>G	c.(391-393)AAT>AGT	p.N131S		NM_020699	NP_065750	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	131						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGAAGCCTCATTGTCAGACAA	0.398		NaN											0	0	0	0.020292	0	13	90									
ASH1L	55870	broad.mit.edu	37	1	155449667	155449667	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:155449667C>G	uc009wqq.2	-	3	3474	c.2994G>C	c.(2992-2994)TTG>TTC	p.L998F	ASH1L_uc001fkt.2_Missense_Mutation_p.L998F|ASH1L_uc009wqr.1_Missense_Mutation_p.L998F	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	998					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GAATCTGATTCAACAGTTTCT	0.313		NaN											0	0	0	0.014758	0	5	75									
APOA1BP	128240	broad.mit.edu	37	1	156563828	156563828	+	Silent	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:156563828G>A	uc001fph.2	+	6	858	c.819G>A	c.(817-819)CTG>CTA	p.L273L	APOA1BP_uc001fpg.2_3'UTR|APOA1BP_uc001fpi.2_Missense_Mutation_p.E255K|APOA1BP_uc001fpj.2_Silent_p.L190L|APOA1BP_uc001fpk.2_Silent_p.L170L|APOA1BP_uc010php.1_Silent_p.L170L	NM_144772	NP_658985	Q8NCW5	AIBP_HUMAN	apolipoprotein A-I binding protein precursor	273	YjeF N-terminal.					extracellular region	protein binding			central_nervous_system(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGTACCAGCTGAACCTGCCAC	0.547		NaN											0	0	0	0.008291	0	7	106									
ARHGAP30	257106	broad.mit.edu	37	1	161018826	161018826	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:161018826T>C	uc001fxl.2	-	12	2331	c.1985A>G	c.(1984-1986)CAG>CGG	p.Q662R	ARHGAP30_uc001fxk.2_Missense_Mutation_p.Q662R|ARHGAP30_uc001fxm.2_Missense_Mutation_p.Q508R|ARHGAP30_uc009wtx.2_Missense_Mutation_p.Q335R|ARHGAP30_uc001fxn.1_Missense_Mutation_p.Q508R	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	662	Glu-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			AGGCTCAGCCTGCTTGTCCTC	0.617		NaN											0	0	0	0.024334	0	26	145									
FMO4	2329	broad.mit.edu	37	1	171303803	171303803	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:171303803G>C	uc001gho.2	+	8	1298	c.1081G>C	c.(1081-1083)GAG>CAG	p.E361Q		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	361					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					CTTAAACCTAGAGAGAGCGAC	0.403		NaN											0	0	0	0.008291	0	10	92									
TPR	7175	broad.mit.edu	37	1	186329966	186329966	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:186329966C>G	uc001grv.2	-	10	1327	c.1030G>C	c.(1030-1032)GAG>CAG	p.E344Q	TPR_uc010pop.1_Missense_Mutation_p.E420Q	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	344	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		CCTATTTTCTCAAGCATTTCT	0.348		NaN	T	NTRK1	papillary thyroid								0	0	0	0.004672	0	3	51									
TPR	7175	broad.mit.edu	37	1	186330823	186330823	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:186330823C>G	uc001grv.2	-	9	1186	c.889G>C	c.(889-891)GAA>CAA	p.E297Q	TPR_uc010pop.1_Missense_Mutation_p.E373Q	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	297	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		CTCTTTGCTTCTGAGTCATCA	0.373		NaN	T	NTRK1	papillary thyroid								0	0	0	0.00308	0	7	78									
MYBPH	4608	broad.mit.edu	37	1	203139485	203139485	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:203139485C>T	uc001gzh.1	-	7	1086	c.1027G>A	c.(1027-1029)GAA>AAA	p.E343K	FMOD_uc010pqi.1_Intron	NM_004997	NP_004988	Q13203	MYBPH_HUMAN	myosin binding protein H	343	Fibronectin type-III 2.				cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle				0			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		CACAGGTTTTCTGAGAAGACC	0.597		NaN											0	0	0	0.004672	0	3	48									
LAX1	54900	broad.mit.edu	37	1	203743363	203743363	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:203743363G>A	uc001haa.2	+	5	1161	c.751G>A	c.(751-753)GAC>AAC	p.D251N	LAX1_uc010pql.1_Missense_Mutation_p.D235N|LAX1_uc001hab.2_Missense_Mutation_p.D175N	NM_017773	NP_060243	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1 isoform a	251	Cytoplasmic (Potential).				B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)	2	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			AGGAGCTGAGGACAGTGATTC	0.488		NaN											0	0	0	0.021553	0	5	40									
SLC26A9	115019	broad.mit.edu	37	1	205902176	205902177	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:205902176_205902177CC>AT	uc001hdq.2	-	3	275_276	c.161_162GG>AT	c.(160-162)GGG>GAT	p.G54D	SLC26A9_uc001hdp.2_Missense_Mutation_p.G54D	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	54	Helical; (Potential).					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			CAGGCAGCAGCCCAAACACCAC	0.55		NaN											0	0	0	0.004672	0	6	42									
CABC1	56997	broad.mit.edu	37	1	227174193	227174193	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:227174193G>T	uc001hqm.1	+	20	5118	c.1699G>T	c.(1699-1701)GGG>TGG	p.G567W	CABC1_uc001hqn.1_Missense_Mutation_p.G567W|CABC1_uc009xeq.1_Missense_Mutation_p.G515W|CABC1_uc010pvq.1_Missense_Mutation_p.G288W|CABC1_uc010pvr.1_Missense_Mutation_p.G241W|CABC1_uc001hqo.1_Missense_Mutation_p.G288W|CABC1_uc009xer.1_Missense_Mutation_p.G83W	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	567					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				CCTCATCCTGGGGGAGGCCTT	0.587		NaN											1	0	0.000157383	0.00308	0.000167958	8	56									
CDC42BPA	8476	broad.mit.edu	37	1	227227863	227227863	+	Silent	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:227227863C>G	uc001hqr.2	-	23	4006	c.3063G>C	c.(3061-3063)GTG>GTC	p.V1021V	CDC42BPA_uc001hqq.2_Silent_p.V320V|CDC42BPA_uc001hqs.2_Silent_p.V940V|CDC42BPA_uc009xes.2_Silent_p.V993V|CDC42BPA_uc010pvs.1_Silent_p.V1001V|CDC42BPA_uc001hqp.2_Silent_p.V177V|CDC42BPA_uc001hqu.1_Silent_p.V228V	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	1034	Phorbol-ester/DAG-type.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				TTATTAAACCCACCATCAAGG	0.343		NaN											0	0	0	0.004482	0	8	58									
LYST	1130	broad.mit.edu	37	1	235972029	235972029	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:235972029G>A	uc001hxj.2	-	5	2264	c.2089C>T	c.(2089-2091)CAG>TAG	p.Q697*	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Nonsense_Mutation_p.Q697*	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	697	WD 1.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ACAAAGTTCTGATAAGCCTTT	0.368		NaN							Chediak-Higashi_syndrome				0	0	0	0.021553	0	6	52									
RYR2	6262	broad.mit.edu	37	1	237756804	237756804	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:237756804G>A	uc001hyl.1	+	33	4424	c.4304G>A	c.(4303-4305)GGA>GAA	p.G1435E		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1435	Cytoplasmic (By similarity).|B30.2/SPRY 3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATCTTTCCTGGACAAGAACCT	0.393		NaN											0	0	0	0.02938	0	6	49									
AHCTF1	25909	broad.mit.edu	37	1	247053295	247053295	+	Missense_Mutation	SNP	C	C	T	rs140782802	byFrequency	TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:247053295C>T	uc001ibu.1	-	16	2124	c.2117G>A	c.(2116-2118)CGT>CAT	p.R706H	AHCTF1_uc001ibv.1_Missense_Mutation_p.R715H|AHCTF1_uc009xgs.1_5'UTR	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	706	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTTCTGTCGACGACTGGTGTA	0.343		NaN											0	0	0	0.014323	0	21	113									
C10orf18	54906	broad.mit.edu	37	10	5762896	5762896	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:5762896C>G	uc001iij.2	+	6	734	c.109C>G	c.(109-111)CTT>GTT	p.L37V		NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	37										ovary(1)|central_nervous_system(1)	2						TGATATAGCTCTTTGGTCCAC	0.333		NaN											0	0	0	0.008291	0	11	71									
SEC61A2	55176	broad.mit.edu	37	10	12204226	12204226	+	Silent	SNP	G	G	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:12204226G>T	uc001ile.2	+	11	1329	c.1182G>T	c.(1180-1182)CTG>CTT	p.L394L	SEC61A2_uc010qbq.1_Silent_p.L372L|SEC61A2_uc001ilf.3_RNA|SEC61A2_uc001ilh.3_RNA|SEC61A2_uc001ilg.3_Silent_p.L394L	NM_018144	NP_060614	Q9H9S3	S61A2_HUMAN	Sec61 alpha form 2 isoform a	394	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1		Renal(717;0.228)				CTAAACAGCTGAAAGAACAGC	0.458		NaN											1	0	1.15088e-07	0.028581	1.29474e-07	14	193									
ERCC6	2074	broad.mit.edu	37	10	50732248	50732248	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:50732248C>T	uc001jhs.3	-	5	1382	c.1228G>A	c.(1228-1230)GGC>AGC	p.G410S	PGBD3_uc001jht.2_5'UTR|PGBD3_uc009xoe.2_Missense_Mutation_p.G410S|PGBD3_uc001jhu.2_Missense_Mutation_p.G410S	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	410					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						CGTTTCCCGCCCTTGGGCAGA	0.393		NaN						Direct_reversal_of_damage|NER					0	0	0	0.004672	0	3	69									
ARID5B	84159	broad.mit.edu	37	10	63829550	63829550	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:63829550A>G	uc001jlt.1	+	8	1219	c.1193A>G	c.(1192-1194)TAT>TGT	p.Y398C	ARID5B_uc001jlu.1_Missense_Mutation_p.Y155C	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	398	ARID.				liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					CGCAGACATTATGAAAGGTAA	0.418		NaN											0	0	0	0.014758	0	4	31									
ACTA2	59	broad.mit.edu	37	10	90701132	90701132	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:90701132G>A	uc001kfp.2	-	6	586	c.470C>T	c.(469-471)TCT>TTT	p.S157F	STAMBPL1_uc010qmx.1_Intron|ACTA2_uc010qmy.1_Missense_Mutation_p.S112F|ACTA2_uc001kfq.2_Missense_Mutation_p.S157F	NM_001613	NP_001604	P62736	ACTA_HUMAN	alpha 2 actin	157					response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		ACCATCTCCAGAGTCCAGCAC	0.562		NaN											0	0	0	0.014758	0	4	50									
PDCD11	22984	broad.mit.edu	37	10	105182763	105182763	+	Missense_Mutation	SNP	C	C	T	rs142899352		TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:105182763C>T	uc001kwy.1	+	18	2603	c.2516C>T	c.(2515-2517)ACG>ATG	p.T839M		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	839					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TTGATCCAGACGCTGGCCGAG	0.527		NaN											0	0	0	0.009096	0	3	49									
C10orf79	80217	broad.mit.edu	37	10	105953694	105953694	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:105953694C>T	uc001kxw.2	-	11	1488	c.1372G>A	c.(1372-1374)GTA>ATA	p.V458I	C10orf79_uc001kxx.3_Missense_Mutation_p.V459I|C10orf79_uc001kxy.1_Missense_Mutation_p.V459I	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	458	WD 7.										0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TTATCATATACGCTGATGAAG	0.552		NaN											0	0	0	0.008291	0	11	58									
SORCS3	22986	broad.mit.edu	37	10	106982877	106982877	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:106982877C>A	uc001kyi.1	+	20	2965	c.2738C>A	c.(2737-2739)CCT>CAT	p.P913H	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	913	PKD.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TCCTTAGGTCCTGTGGAGCAT	0.428		NaN											1	0	7.48243e-07	0.006214	8.31381e-07	10	83									
ATRNL1	26033	broad.mit.edu	37	10	117704277	117704277	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:117704277G>A	uc001lcg.2	+	29	4513	c.4127G>A	c.(4126-4128)GGA>GAA	p.G1376E	ATRNL1_uc010qsm.1_Missense_Mutation_p.G505E|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1376	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		ACACGTCAAGGAACTTGTGTC	0.413		NaN											0	0	0	0.024245	0	14	91									
INPP5F	22876	broad.mit.edu	37	10	121563770	121563770	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:121563770C>T	uc001leo.2	+	10	1368	c.1202C>T	c.(1201-1203)TCA>TTA	p.S401L		NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	401	SAC.						phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		TTCAACAACTCACACCTCACT	0.418		NaN											0	0	0	0.008291	0	10	108									
DUSP8	1850	broad.mit.edu	37	11	1579411	1579411	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:1579411G>A	uc001lts.2	-	5	756	c.628C>T	c.(628-630)CGG>TGG	p.R210W		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	210	Tyrosine-protein phosphatase.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		ATGGGGACCCGCATGAAGCGG	0.582		NaN											0	0	0	0.009096	0	4	104									
TNNI2	7136	broad.mit.edu	37	11	1861878	1861878	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:1861878G>A	uc010qxe.1	+	3	200	c.178G>A	c.(178-180)GAA>AAA	p.E60K	TNNI2_uc010qxc.1_Missense_Mutation_p.E58K|TNNI2_uc010qxd.1_Missense_Mutation_p.E58K	NM_001145841	NP_001139313	P48788	TNNI2_HUMAN	fast-twitch skeletal muscle troponin I isoform	60					muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding				0		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CTCCATGTCTGAAGTGCAGGT	0.667		NaN											0	0	0	0.014758	0	4	32									
OR51S1	119692	broad.mit.edu	37	11	4869937	4869937	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:4869937G>A	uc010qyo.1	-	1	502	c.502C>T	c.(502-504)CCA>TCA	p.P168S		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	168	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCAGGAATGGCAGGGGCAGA	0.552		NaN											0	0	0	0.02938	0	5	92									
SMPD1	6609	broad.mit.edu	37	11	6415196	6415196	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:6415196G>A	uc001mcw.2	+	5	1585	c.1411G>A	c.(1411-1413)GAA>AAA	p.E471K	SMPD1_uc001mcv.1_RNA|SMPD1_uc009yex.2_RNA|SMPD1_uc001mcx.2_Missense_Mutation_p.E427K|SMPD1_uc009yew.2_Missense_Mutation_p.E470K	NM_000543	NP_000534	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid	469					cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	CTTCTATGATGAAGAGACTCT	0.527		NaN											0	0	0	0.02938	0	7	65									
EIF4G2	1982	broad.mit.edu	37	11	10821761	10821761	+	Silent	SNP	T	T	C	rs140144694		TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:10821761T>C	uc001mjc.2	-	18	2412	c.1995A>G	c.(1993-1995)CTA>CTG	p.L665L	EIF4G2_uc001mjb.2_Silent_p.L459L|EIF4G2_uc009ygf.2_Silent_p.L459L|EIF4G2_uc001mjd.2_Silent_p.L627L	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	665	MI.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		TGCCACTTTCTAGTGGTTGAG	0.423		NaN											0	0	0	0.008291	0	11	49									
MICAL2	9645	broad.mit.edu	37	11	12265655	12265655	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:12265655G>A	uc001mjz.2	+	21	3068	c.2780G>A	c.(2779-2781)AGA>AAA	p.R927K	MICAL2_uc010rch.1_Intron|MICAL2_uc001mka.2_Missense_Mutation_p.R927K|MICAL2_uc010rci.1_Missense_Mutation_p.R927K|MICAL2_uc001mkb.2_Intron|MICAL2_uc001mkc.2_Intron|MICAL2_uc001mkd.2_Intron|MICAL2_uc010rcj.1_Intron|MICAL2_uc001mkf.2_RNA	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	927						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		TCTCCTGCCAGAAAGGTAGTT	0.502		NaN											0	0	0	0.0333	0	14	187									
ABCC8	6833	broad.mit.edu	37	11	17474774	17474774	+	Silent	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:17474774G>A	uc001mnc.2	-	7	1194	c.1068C>T	c.(1066-1068)TAC>TAT	p.Y356Y	ABCC8_uc010rcy.1_Silent_p.Y355Y	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	356	Helical; Name=7; (By similarity).|ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CAGCTAAGACGTAGGCATTGG	0.458		NaN											0	0	0	0.014758	0	4	70									
LMO2	4005	broad.mit.edu	37	11	33886306	33886306	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:33886306G>T	uc001mve.2	-	2	538	c.99C>A	c.(97-99)TGC>TGA	p.C33*	LMO2_uc001mvc.2_Nonsense_Mutation_p.C26*|LMO2_uc001mvd.2_Nonsense_Mutation_p.C26*|LMO2_uc010rel.1_Nonsense_Mutation_p.C33*|LMO2_uc010rem.1_Nonsense_Mutation_p.C102*	NM_001142316	NP_001135788	P25791	RBTN2_HUMAN	LIM domain only 2 isoform 2	33	LIM zinc-binding 1.				multicellular organismal development	nucleus	protein binding|zinc ion binding			lung(1)	1						TGTTCTGCTGGCAGCCGCCGC	0.627		NaN	T	TRD@	T-ALL								1	0	5.9392e-07	0.021553	6.62638e-07	6	48									
TM7SF2	7108	broad.mit.edu	37	11	64883439	64883439	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:64883439G>C	uc001oct.2	+	10	1318	c.1171G>C	c.(1171-1173)GAG>CAG	p.E391Q	TM7SF2_uc010rny.1_Missense_Mutation_p.E275Q|TM7SF2_uc001ocu.2_Missense_Mutation_p.E364Q|TM7SF2_uc001ocv.2_Missense_Mutation_p.E412Q|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	391					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						GGCCCGGGATGAGCGGCAGTG	0.622		NaN											0	0	0	0.009096	0	4	36									
MOGAT2	80168	broad.mit.edu	37	11	75439097	75439097	+	Silent	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:75439097G>A	uc010rru.1	+	4	558	c.558G>A	c.(556-558)GGG>GGA	p.G186G	MOGAT2_uc001oww.1_Silent_p.G186G|MOGAT2_uc010rrv.1_Silent_p.G104G	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	186					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					TCATTGTAGGGGGTGCCCAGG	0.562		NaN											0	0	0	0.004672	0	3	38									
PCF11	51585	broad.mit.edu	37	11	82877725	82877725	+	Silent	SNP	A	A	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:82877725A>C	uc001ozx.3	+	5	2131	c.1786A>C	c.(1786-1788)AGA>CGA	p.R596R	PCF11_uc010rsu.1_Silent_p.R596R	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	596					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						GTCTGCCAAAAGATGGAAATC	0.348		NaN											0	0	0	0.014758	0	4	75									
FAT3	120114	broad.mit.edu	37	11	92087450	92087450	+	Nonsense_Mutation	SNP	T	T	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:92087450T>G	uc001pdj.3	+	1	2189	c.2172T>G	c.(2170-2172)TAT>TAG	p.Y724*		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	724	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGGGACCATATTTTGACAAGT	0.403		NaN								TCGA Ovarian(4;0.039)			0	0	0	0.010504	0	18	155									
CCDC67	159989	broad.mit.edu	37	11	93103298	93103298	+	Silent	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:93103298G>C	uc001pdq.2	+	6	592	c.492G>C	c.(490-492)CTG>CTC	p.L164L	CCDC67_uc001pdo.1_Silent_p.L164L|CCDC67_uc001pdp.2_Silent_p.L164L	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	164	Potential.									ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				AGACTCATCTGATTTCTTTAG	0.289		NaN											0	0	0	0.014758	0	5	14									
CASP5	838	broad.mit.edu	37	11	104868181	104868181	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:104868181A>C	uc010rva.1	-	8	1167	c.1135T>G	c.(1135-1137)TTC>GTC	p.F379V	CASP5_uc010ruz.1_Missense_Mutation_p.F392V|CASP5_uc010rvb.1_Missense_Mutation_p.F321V|CASP5_uc010rvc.1_Missense_Mutation_p.F237V|CASP5_uc009yxh.2_Missense_Mutation_p.F161V|CASP5_uc010rvd.1_Missense_Mutation_p.F161V	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	379					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		TCCGTAATGAAGATGGAGCCC	0.408		NaN											0	0	0	0.02938	0	6	39									
ARCN1	372	broad.mit.edu	37	11	118452000	118452000	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:118452000G>A	uc001ptq.2	+	2	204	c.43G>A	c.(43-45)GCT>ACT	p.A15T	ARCN1_uc009zah.2_Missense_Mutation_p.A15T|ARCN1_uc010ryg.1_Intron|ARCN1_uc009zag.2_Missense_Mutation_p.A56T	NM_001655	NP_001646	P48444	COPD_HUMAN	archain isoform 1	15					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	clathrin adaptor complex|COPI vesicle coat|cytosol					0	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		AGCAGGAAAGGCTATTGTTTC	0.428		NaN											0	0	0	0.020292	0	12	109									
IGSF9B	22997	broad.mit.edu	37	11	133794727	133794727	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:133794727C>T	uc001qgx.3	-	15	2338	c.2107G>A	c.(2107-2109)GTC>ATC	p.V703I	IGSF9B_uc001qgy.1_Missense_Mutation_p.V545I	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	703	Fibronectin type-III 2.|Extracellular (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GTGCTGGAGACGCCGGCGATG	0.562		NaN											0	0	0	0.014758	0	4	94									
SCNN1A	6337	broad.mit.edu	37	12	6483849	6483849	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:6483849T>C	uc001qnx.2	-	2	390	c.101A>G	c.(100-102)GAA>GGA	p.E34G	SCNN1A_uc001qnw.2_Missense_Mutation_p.E93G|SCNN1A_uc010sfb.1_Missense_Mutation_p.E57G|LTBR_uc010sfc.1_5'Flank	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	34	Cytoplasmic (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	CGCCGCAGGTTCGGGGCCCAG	0.642		NaN											0	0	0	0.004672	0	3	34									
CLEC1B	51266	broad.mit.edu	37	12	10149501	10149501	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:10149501G>A	uc001qwu.2	-	4	582	c.382C>T	c.(382-384)CAG>TAG	p.Q128*	CLEC1B_uc009zhd.2_Nonsense_Mutation_p.Q95*	NM_016509	NP_057593	Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B isoform	128	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity				0						GTGCAGTACTGCTTACTCTCT	0.423		NaN											0	0	0	0.021553	0	6	127									
ETV6	2120	broad.mit.edu	37	12	12037408	12037408	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:12037408C>T	uc001qzz.2	+	6	1313	c.1039C>T	c.(1039-1041)CAG>TAG	p.Q347*	ETV6_uc001raa.1_Intron	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	347	ETS.					cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				TTACGTCTATCAGTTGCTTTC	0.443		NaN	T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								0	0	0	0.028581	0	14	136									
AMN1	196394	broad.mit.edu	37	12	31850769	31850769	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:31850769C>T	uc001rkq.3	-	4	605	c.439G>A	c.(439-441)GAT>AAT	p.D147N	AMN1_uc001rko.3_Missense_Mutation_p.D129N|AMN1_uc010skc.1_Missense_Mutation_p.D129N|AMN1_uc001rkp.3_Missense_Mutation_p.D129N|AMN1_uc009zjs.2_RNA|AMN1_uc009zjt.1_RNA	NM_001113402	NP_001106873	Q8IY45	AMN1_HUMAN	antagonist of mitotic exit network 1 homolog	147											0	all_cancers(9;7.41e-12)|all_epithelial(9;1.18e-11)|all_lung(12;1.14e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.162)		OV - Ovarian serous cystadenocarcinoma(6;0.0014)			CCACCTAAATCGATGATCTTT	0.418		NaN											0	0	0	0.009096	0	4	75									
AMIGO2	347902	broad.mit.edu	37	12	47472350	47472350	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:47472350G>T	uc001rpm.2	-	3	1091	c.436C>A	c.(436-438)CTT>ATT	p.L146I	FAM113B_uc001rpn.2_5'Flank|AMIGO2_uc001rpk.2_Missense_Mutation_p.L146I|AMIGO2_uc001rpl.2_Missense_Mutation_p.L146I	NM_001143668	NP_001137140	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	146	Extracellular (Potential).|LRR 4.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				ovary(1)|skin(1)	2	Renal(347;0.138)|Lung SC(27;0.192)					TAAAGCAGAAGCACTTCCAGA	0.408		NaN											1	0	5.18039e-06	0.00308	5.6858e-06	8	107									
ACCN2	41	broad.mit.edu	37	12	50453726	50453726	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:50453726G>A	uc001rvw.2	+	3	776	c.547G>A	c.(547-549)GAC>AAC	p.D183N	ACCN2_uc001rvv.2_Missense_Mutation_p.D183N|ACCN2_uc009zln.2_5'UTR|ACCN2_uc009zlo.2_Missense_Mutation_p.D183N	NM_001095	NP_001086	P78348	ACCN2_HUMAN	amiloride-sensitive cation channel 2, neuronal	183	Extracellular (By similarity).				calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(1)	1					Amiloride(DB00594)	CAGCGCTGAAGACTTCAAGGT	0.617		NaN											0	0	0	0.014758	0	5	39									
SLC4A8	9498	broad.mit.edu	37	12	51890800	51890800	+	Silent	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:51890800C>G	uc001rys.1	+	22	3151	c.2973C>G	c.(2971-2973)GTC>GTG	p.V991V	SLC4A8_uc001rym.2_Silent_p.V938V|SLC4A8_uc001ryn.2_Silent_p.V938V|SLC4A8_uc001ryo.2_Silent_p.V938V|SLC4A8_uc010snj.1_Silent_p.V1018V|SLC4A8_uc001ryr.2_Silent_p.V991V	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	991	Cytoplasmic (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		TCAGGAAAGTCATGGATCTCT	0.398		NaN											0	0	0	0.021553	0	5	75									
RARG	5916	broad.mit.edu	37	12	53607445	53607445	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:53607445T>C	uc001sce.2	-	8	1338	c.853A>G	c.(853-855)ACC>GCC	p.T285A	RARG_uc001scd.2_Missense_Mutation_p.T274A|RARG_uc010sob.1_Missense_Mutation_p.T263A|RARG_uc001scf.2_Missense_Mutation_p.T285A|RARG_uc001scg.2_Missense_Mutation_p.T213A|RARG_uc010soc.1_Missense_Mutation_p.T164A|RARG_uc010sod.1_Missense_Mutation_p.T322A	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	285	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	AAGGTCATGGTGTCCTGCTCT	0.597		NaN									OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	57									
ZNF385A	25946	broad.mit.edu	37	12	54765456	54765456	+	Silent	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:54765456C>T	uc001sfw.1	-	4	588	c.405G>A	c.(403-405)GAG>GAA	p.E135E	ZNF385A_uc001sfv.1_Silent_p.E116E|ZNF385A_uc009zno.1_Intron|ZNF385A_uc010sov.1_Intron|ZNF385A_uc001sfx.1_Silent_p.E135E|ZNF385A_uc001sfy.3_Silent_p.E155E|ZNF385A_uc001sfz.3_Intron	NM_015481	NP_056296	Q96PM9	Z385A_HUMAN	zinc finger protein 385A isoform c	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1						CAGGCTGTTTCTCTGGGGATC	0.602		NaN											0	0	0	0.020292	0	13	63									
RNF41	10193	broad.mit.edu	37	12	56600547	56600547	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:56600547C>T	uc001skf.1	-	7	1007	c.638G>A	c.(637-639)CGC>CAC	p.R213H	RNF41_uc001ske.1_Missense_Mutation_p.R142H|RNF41_uc001skg.1_Missense_Mutation_p.R213H|RNF41_uc010sqg.1_Missense_Mutation_p.R148H|RNF41_uc010sqh.1_Missense_Mutation_p.R142H	NM_005785	NP_005776	Q9H4P4	RNF41_HUMAN	ring finger protein 41 isoform 1	213					apoptosis|induction of apoptosis|protein polyubiquitination|regulation of reactive oxygen species metabolic process		protein binding|protein tag|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1						CCCTCCCCAGCGGGTCACTCT	0.537		NaN									OREG0021921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	31									
LGR5	8549	broad.mit.edu	37	12	71977788	71977788	+	Silent	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:71977788G>A	uc001swl.2	+	18	2046	c.1998G>A	c.(1996-1998)GTG>GTA	p.V666V	LGR5_uc001swm.2_Silent_p.V642V|LGR5_uc001swn.1_Intron	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	666	Cytoplasmic (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						GGTTCTCTGTGAAATATTCTG	0.463		NaN											0	0	0	0.016723	0	13	142									
TRHDE	29953	broad.mit.edu	37	12	73046177	73046177	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:73046177A>G	uc001sxa.2	+	16	2646	c.2616A>G	c.(2614-2616)ATA>ATG	p.I872M		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	872	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						GGGAATTCATATGGATGAAAT	0.398		NaN											0	0	0	0.021553	0	6	74									
HSP90B1	7184	broad.mit.edu	37	12	104336352	104336352	+	Silent	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:104336352G>A	uc001tkb.1	+	12	1527	c.1422G>A	c.(1420-1422)AAG>AAA	p.K474K	HSP90B1_uc010swg.1_Silent_p.K139K|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	474					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	TGATCAAGAAGATTGCTGATG	0.363		NaN											0	0	0	0.009096	0	4	54									
HSP90B1	7184	broad.mit.edu	37	12	104336359	104336359	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:104336359G>T	uc001tkb.1	+	12	1534	c.1429G>T	c.(1429-1431)GAT>TAT	p.D477Y	HSP90B1_uc010swg.1_Missense_Mutation_p.D142Y|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	477					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	GAAGATTGCTGATGATAAATA	0.363		NaN											1	0	0.00909568	0.009096	0.00944551	4	59									
HSP90B1	7184	broad.mit.edu	37	12	104336567	104336567	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:104336567G>C	uc001tkb.1	+	12	1742	c.1637G>C	c.(1636-1638)AGA>ACA	p.R546T	HSP90B1_uc010swg.1_Missense_Mutation_p.R211T|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	546					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	GGGTCCAGCAGAAAAGAGGTG	0.418		NaN											0	0	0	0.021553	0	6	71									
CIT	11113	broad.mit.edu	37	12	120159203	120159203	+	Silent	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:120159203G>A	uc001txi.1	-	28	3570	c.3517C>T	c.(3517-3519)CTG>TTG	p.L1173L	CIT_uc001txh.1_Silent_p.L707L|CIT_uc001txj.1_Silent_p.L1215L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1173	Potential.|Interaction with Rho/Rac.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CCTTGAGTCAGACGGAAAATG	0.468		NaN											0	0	0	0.010729	0	11	62									
GLT1D1	144423	broad.mit.edu	37	12	129373237	129373237	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:129373237G>A	uc010tbh.1	+	3	247	c.238G>A	c.(238-240)GCC>ACC	p.A80T	GLT1D1_uc001uhx.1_Missense_Mutation_p.A91T|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	91					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		AAATGAAGATGCCAACCAGGC	0.438		NaN											0	0	0	0.009096	0	4	23									
GOLGA3	2802	broad.mit.edu	37	12	133374950	133374950	+	Silent	SNP	G	G	T	rs139706790		TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:133374950G>T	uc001ukz.1	-	9	2473	c.1914C>A	c.(1912-1914)ATC>ATA	p.I638I	GOLGA3_uc001ula.1_Silent_p.I638I|GOLGA3_uc001ulb.2_Silent_p.I638I	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	638	Gln-rich.|Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GCTGTGCCGCGATGCGCCCCT	0.587		NaN											1	0	8.12818e-05	0.02938	8.77844e-05	7	87									
TNFRSF19	55504	broad.mit.edu	37	13	24243107	24243107	+	Silent	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr13:24243107T>C	uc001uov.1	+	9	1180	c.1116T>C	c.(1114-1116)GCT>GCC	p.A372A	TNFRSF19_uc001uot.2_Silent_p.A372A|TNFRSF19_uc010tcu.1_Silent_p.A240A|TNFRSF19_uc001uow.2_Silent_p.A372A	NM_018647	NP_061117	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily,	372	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		TTACAGCAGCTACTGATTTAT	0.428		NaN											0	0	0	0.004672	0	3	86									
FAM123A	219287	broad.mit.edu	37	13	25744014	25744014	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr13:25744014A>T	uc001uqb.2	-	1	1844	c.1744T>A	c.(1744-1746)TCC>ACC	p.S582T	FAM123A_uc001uqa.2_Missense_Mutation_p.S463T|FAM123A_uc001uqc.2_Missense_Mutation_p.S463T	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	582										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TTTAACCGGGACAGGGAGGAC	0.567		NaN											0	0	0	0.021553	0	3	70									
KIAA0564	23078	broad.mit.edu	37	13	42385394	42385394	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr13:42385394A>C	uc001uyj.2	-	17	2100	c.2030T>G	c.(2029-2031)CTT>CGT	p.L677R	KIAA0564_uc001uyk.2_Missense_Mutation_p.L677R	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	677						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		AGCACTGTGAAGATTTTCATT	0.383		NaN											0	0	0	0.02938	0	6	53									
NID2	22795	broad.mit.edu	37	14	52481073	52481073	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr14:52481073T>C	uc001wzo.2	-	16	3586	c.3352A>G	c.(3352-3354)ATT>GTT	p.I1118V	NID2_uc010tqs.1_Missense_Mutation_p.I1070V|NID2_uc010tqt.1_Missense_Mutation_p.I1118V|NID2_uc001wzp.2_Missense_Mutation_p.I1118V	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1118						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					AAGTAGCCAATCTGCTGGCCC	0.592		NaN									OREG0022678	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	10	40									
LTBP2	4053	broad.mit.edu	37	14	74973930	74973930	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr14:74973930G>C	uc001xqa.2	-	26	4246	c.3859C>G	c.(3859-3861)CTG>GTG	p.L1287V		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1287	EGF-like 14; calcium-binding (Potential).|Cys-rich.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		TGGCAGCCCAGAACACAGCGG	0.567		NaN											0	0	0	0.00308	0	6	57									
BDKRB1	623	broad.mit.edu	37	14	96730151	96730151	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr14:96730151C>G	uc001yfh.2	+	3	340	c.132C>G	c.(130-132)ATC>ATG	p.I44M	BDKRB1_uc010avn.2_Missense_Mutation_p.I44M	NM_000710	NP_000701	P46663	BKRB1_HUMAN	bradykinin receptor B1	44	Helical; Name=1; (Potential).				elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			ovary(3)	3		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		CAACATTTATCATCTCCATCT	0.542		NaN											0	0	0	0.009096	0	4	51									
AHNAK2	113146	broad.mit.edu	37	14	105408255	105408255	+	Silent	SNP	G	G	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr14:105408255G>T	uc010axc.1	-	7	13653	c.13533C>A	c.(13531-13533)CTC>CTA	p.L4511L	AHNAK2_uc001ypx.2_Silent_p.L4411L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4511						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTGAATGCGGAGGTCAGTGG	0.622		NaN											1	0	1.33986e-20	0.024334	1.546e-20	27	154									
AHNAK2	113146	broad.mit.edu	37	14	105408514	105408514	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr14:105408514G>A	uc010axc.1	-	7	13394	c.13274C>T	c.(13273-13275)TCT>TTT	p.S4425F	AHNAK2_uc001ypx.2_Missense_Mutation_p.S4325F	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4425						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCTGGGCAGAGACACGTCCAG	0.622		NaN											0	0	0	0.028581	0	14	145									
CORO2B	10391	broad.mit.edu	37	15	68937670	68937671	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr15:68937670_68937671GG>AT	uc002arj.3	+	2	216_217	c.187_188GG>AT	c.(187-189)GGC>ATC	p.G63I	CORO2B_uc010bic.2_Missense_Mutation_p.G58I	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	63					actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6						CGCAGGGGGCGGCTCCTTCCTC	0.624		NaN											0	0	0	0.004672	0	4	68									
TSPAN3	10099	broad.mit.edu	37	15	77345133	77345133	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr15:77345133C>A	uc002bcj.2	-	5	788	c.571G>T	c.(571-573)GAC>TAC	p.D191Y	TSPAN3_uc002bck.2_Missense_Mutation_p.D166Y|TSPAN3_uc010ump.1_Missense_Mutation_p.D127Y|TSPAN3_uc010bkx.2_Missense_Mutation_p.D102Y	NM_005724	NP_005715	O60637	TSN3_HUMAN	transmembrane 4 superfamily member 8 isoform 1	191	Extracellular (Potential).					integral to membrane					0				all cancers(203;1.14e-19)		GCATAGAGGTCGGAAGGGTGG	0.478		NaN											1	0	3.59834e-05	0.021553	3.90181e-05	5	25									
SGK269	79834	broad.mit.edu	37	15	77472430	77472430	+	Silent	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr15:77472430C>T	uc002bcm.2	-	3	2147	c.1839G>A	c.(1837-1839)GAG>GAA	p.E613E	SGK269_uc002bcn.2_Silent_p.E613E	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	613					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		CATAAGTTGGCTCGTCATGAA	0.348		NaN											0	0	0	0.016723	0	11	142									
TMC3	342125	broad.mit.edu	37	15	81625521	81625521	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr15:81625521C>T	uc002bgo.1	-	22	2542	c.2542G>A	c.(2542-2544)GAA>AAA	p.E848K	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	848	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						TGTACATCTTCGATGTGCGTT	0.527		NaN											0	0	0	0.004482	0	9	93									
DET1	55070	broad.mit.edu	37	15	89074506	89074506	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr15:89074506C>A	uc002bmr.2	-	2	583	c.431G>T	c.(430-432)TGT>TTT	p.C144F	DET1_uc002bmp.3_RNA|DET1_uc010bnk.2_RNA|DET1_uc002bmq.2_Missense_Mutation_p.C155F	NM_001144074	NP_001137546	Q7L5Y6	DET1_HUMAN	de-etiolated 1 isoform 2	144						nucleus				lung(1)|pancreas(1)	2	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			GAAGAGACTACACTCCCGGTT	0.537		NaN											1	0	0.000602214	0.014758	0.000630224	5	25									
NR2F2	7026	broad.mit.edu	37	15	96880592	96880592	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr15:96880592C>T	uc010uri.1	+	3	2210	c.986C>T	c.(985-987)TCT>TTT	p.S329F	NR2F2_uc002btp.2_Missense_Mutation_p.S196F|NR2F2_uc010urj.1_Missense_Mutation_p.S176F|NR2F2_uc010urk.1_Missense_Mutation_p.S176F	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	329	Interaction with ZFPM2 (By similarity).|Ligand-binding (By similarity).				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			TGTGGTCTCTCTGATGTAGCC	0.353		NaN											0	0	0	0.021553	0	6	66									
ZNF263	10127	broad.mit.edu	37	16	3339743	3339743	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:3339743G>T	uc002cuq.2	+	6	1569	c.1237G>T	c.(1237-1239)GAA>TAA	p.E413*	ZNF263_uc010uww.1_Nonsense_Mutation_p.E61*|ZNF263_uc002cur.2_Nonsense_Mutation_p.E61*	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	413					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						GGACTGCACTGAAATCTTTGG	0.473		NaN											1	0	3.09899e-07	0.004482	3.47189e-07	9	91									
CREBBP	1387	broad.mit.edu	37	16	3817750	3817750	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:3817750G>C	uc002cvv.2	-	16	3425	c.3221C>G	c.(3220-3222)TCA>TGA	p.S1074*	CREBBP_uc002cvw.2_Nonsense_Mutation_p.S1036*	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1074					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AGGAGATGTTGACTGAGAGGC	0.428		NaN	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.013537	0	11	138									
CORO7	79585	broad.mit.edu	37	16	4466517	4466517	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:4466517C>T	uc002cwh.3	-	1	123	c.3G>A	c.(1-3)ATG>ATA	p.M1I	CORO7_uc002cwf.2_Missense_Mutation_p.M1I|CORO7_uc002cwg.3_5'Flank|CORO7_uc010uxh.1_Missense_Mutation_p.M1I|CORO7_uc010uxi.1_Missense_Mutation_p.M1I|CORO7_uc010uxj.1_RNA|CORO7_uc010btp.1_5'UTR|CORO7_uc010btr.1_RNA	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	1						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						TGAAGCGGTTCATGGCGACGG	0.756		NaN											0	0	0	0.009096	0	4	23									
SMG1	23049	broad.mit.edu	37	16	18859259	18859259	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:18859259G>A	uc002dfm.2	-	37	6083	c.5720C>T	c.(5719-5721)TCT>TTT	p.S1907F	SMG1_uc010bwb.2_Missense_Mutation_p.S1767F|SMG1_uc010bwa.2_Missense_Mutation_p.S638F|SMG1_uc002dfo.3_Missense_Mutation_p.S205F	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1907	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						GCTATCCTGAGATGCAGGAGG	0.398		NaN											0	0	0	0.016723	0	13	63									
DNAH3	55567	broad.mit.edu	37	16	20997001	20997001	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:20997001C>G	uc010vbe.1	-	48	7063	c.7063G>C	c.(7063-7065)GAT>CAT	p.D2355H	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2355					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ATGTTATCATCGACTATCTTT	0.458		NaN											0	0	0	0.010729	0	11	108									
THAP11	57215	broad.mit.edu	37	16	67876802	67876802	+	Silent	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:67876802G>A	uc002euo.2	+	1	590	c.345G>A	c.(343-345)CAG>CAA	p.Q115Q	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	115	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		agcaacagcagcaacagcagc	0.303		NaN											0	0	0	0.004672	0	3	64									
SLC12A4	6560	broad.mit.edu	37	16	67979985	67979985	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:67979985C>G	uc002euz.2	-	20	2749	c.2608G>C	c.(2608-2610)GTC>CTC	p.V870L	LCAT_uc002euy.1_5'Flank|SLC12A4_uc010ceu.2_Missense_Mutation_p.V864L|SLC12A4_uc010vkh.1_Missense_Mutation_p.V839L|SLC12A4_uc010vki.1_Missense_Mutation_p.V870L|SLC12A4_uc010vkj.1_Missense_Mutation_p.V872L|SLC12A4_uc002eva.2_Missense_Mutation_p.V870L|SLC12A4_uc010cev.1_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	870	Cytoplasmic (Potential).				cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TTCCTCCAGACCTGAGGCAAG	0.592		NaN											0	0	0	0.004672	0	3	39									
ZFHX3	463	broad.mit.edu	37	16	72992721	72992721	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:72992721C>T	uc002fck.2	-	2	1997	c.1324G>A	c.(1324-1326)GAG>AAG	p.E442K	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	442					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				TCCTGCTTCTCTCCTTCTGCC	0.463		NaN											0	0	0	0.028581	0	13	111									
FAM57A	79850	broad.mit.edu	37	17	641131	641131	+	Missense_Mutation	SNP	G	G	A	rs143392294	byFrequency	TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:641131G>A	uc002frp.2	+	3	293	c.252G>A	c.(250-252)ATG>ATA	p.M84I	FAM57A_uc002frq.2_Missense_Mutation_p.M84I|FAM57A_uc002frr.2_5'UTR	NM_024792	NP_079068	Q8TBR7	FA57A_HUMAN	family with sequence similarity 57, member A	84	TLC.|Helical; (Potential).					integral to membrane|plasma membrane					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0217)		TTCCATACATGATCTATGACT	0.483		NaN											0	0	0	0.020292	0	14	155									
ZZEF1	23140	broad.mit.edu	37	17	4015972	4015972	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:4015972C>G	uc002fxe.2	-	5	1061	c.997G>C	c.(997-999)GAT>CAT	p.D333H	ZZEF1_uc002fxk.1_Missense_Mutation_p.D333H	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	333	DOC.						calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ATGTGCACATCTCGGACTTCC	0.542		NaN											0	0	0	0.009096	0	4	34									
C17orf81	23587	broad.mit.edu	37	17	7162203	7162203	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:7162203C>T	uc002gfg.1	+	8	901	c.794C>T	c.(793-795)GCC>GTC	p.A265V	C17orf81_uc002gfj.2_3'UTR|C17orf81_uc010cmb.2_3'UTR|C17orf81_uc002gfh.1_Missense_Mutation_p.A265V|C17orf81_uc002gfi.1_Missense_Mutation_p.A265V|C17orf81_uc002gfl.1_Intron	NM_203415	NP_981960	Q8TE02	DERP6_HUMAN	S-phase 2 protein isoform 4	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding				0						GAGAGAGAAGCCAGAGATAGC	0.517		NaN											0	0	0	0.008291	0	10	55									
TP53	7157	broad.mit.edu	37	17	7577103	7577103	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:7577103C>G	uc002gim.2	-	8	1029	c.835G>C	c.(835-837)GGG>CGG	p.G279R	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.G279R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G147R|TP53_uc010cng.1_Missense_Mutation_p.G147R|TP53_uc002gii.1_Missense_Mutation_p.G147R|TP53_uc010cnh.1_Missense_Mutation_p.G279R|TP53_uc010cni.1_Missense_Mutation_p.G279R|TP53_uc002gij.2_Missense_Mutation_p.G279R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	279	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> E (in sporadic cancers; somatic mutation).|G -> R (in sporadic cancers; somatic mutation).|G -> W (in sporadic cancers; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G279E(31)|p.G279R(7)|p.0?(7)|p.R280fs*65(6)|p.G279V(4)|p.G279G(3)|p.G279W(2)|p.?(2)|p.G279fs*65(2)|p.G279fs*27(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.P278_G279insXXXXX(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275fs*20(1)|p.G279fs*26(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTCTCTCCCAGGACAGGCA	0.547		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.004672	0	3	30									
KRBA2	124751	broad.mit.edu	37	17	8273001	8273001	+	Silent	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:8273001T>C	uc002glf.1	-	2	936	c.930A>G	c.(928-930)TTA>TTG	p.L310L	KRBA2_uc002glg.1_Silent_p.L227L	NM_213597	NP_998762	Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	310	Integrase catalytic.				DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding				0						TGAAAATATCTAACAAGACAC	0.418		NaN											0	0	0	0.021553	0	6	44									
ATPAF2	91647	broad.mit.edu	37	17	17921970	17921970	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:17921970G>A	uc002gse.1	-	8	916	c.763C>T	c.(763-765)CAT>TAT	p.H255Y	ATPAF2_uc002gsd.1_Intron|ATPAF2_uc002gsf.1_RNA	NM_145691	NP_663729	Q8N5M1	ATPF2_HUMAN	ATP synthase mitochondrial F1 complex assembly	255					proton-transporting ATP synthase complex assembly	mitochondrion|nuclear speck	protein binding				0	all_neural(463;0.228)					TCATAGTCATGGGCCCACTCA	0.607		NaN											0	0	0	0.006214	0	7	114									
GIT1	28964	broad.mit.edu	37	17	27909741	27909741	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:27909741C>T	uc002hef.2	-	4	594	c.380G>A	c.(379-381)GGA>GAA	p.G127E	GIT1_uc002heg.2_Missense_Mutation_p.G127E|GIT1_uc010wbg.1_Missense_Mutation_p.G127E|GIT1_uc010csb.1_Missense_Mutation_p.G127E	NM_014030	NP_054749	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interactor 1	127					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding				0				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		GGCGGTGACTCCATCATCGTC	0.577		NaN											0	0	0	0.004672	0	3	30									
STH	246744	broad.mit.edu	37	17	44076786	44076786	+	Silent	SNP	C	C	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:44076786C>A	uc002ijy.2	+	1	171	c.141C>A	c.(139-141)ACC>ACA	p.T47T	MAPT_uc010dau.2_Intron|MAPT_uc002ijr.3_Intron|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_001007532	NP_001007533	Q8IWL8	STH_HUMAN	saitohin	47						cytoplasm|nucleus					0						GAGACAGAACCCTCAGCTTAG	0.413		NaN											1	0	0.000602214	0.014758	0.000630224	5	42									
SP2	6668	broad.mit.edu	37	17	46000404	46000404	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:46000404C>T	uc002imk.2	+	4	1273	c.1136C>T	c.(1135-1137)ACC>ATC	p.T379I	SP2_uc002iml.2_Missense_Mutation_p.T372I	NM_003110	NP_003101	Q02086	SP2_HUMAN	Sp2 transcription factor	379					immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|histone deacetylase binding|zinc ion binding				0						GCTGCAGCCACCTCTAACACC	0.587		NaN											0	0	0	0.016723	0	13	69									
DLX3	1747	broad.mit.edu	37	17	48072068	48072068	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:48072068G>A	uc002ipy.2	-	1	521	c.295C>T	c.(295-297)CGG>TGG	p.R99W		NM_005220	NP_005211	O60479	DLX3_HUMAN	distal-less homeobox 3	99						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGCTGCTCCCGATACGCCCCG	0.627		NaN											0	0	0	0.004482	0	8	29									
BRIP1	83990	broad.mit.edu	37	17	59934548	59934548	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:59934548A>T	uc002izk.1	-	4	391	c.250T>A	c.(250-252)TTG>ATG	p.L84M		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	84	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						CAACATGACAATTGTACTTCA	0.343		NaN	F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.016723	0	13	72									
KCNH6	81033	broad.mit.edu	37	17	61623123	61623123	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:61623123C>G	uc002jay.2	+	14	2925	c.2845C>G	c.(2845-2847)CTA>GTA	p.L949V	KCNH6_uc010wpl.1_Missense_Mutation_p.L790V|KCNH6_uc010wpm.1_Missense_Mutation_p.L913V|KCNH6_uc002jaz.1_Missense_Mutation_p.L860V	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	949	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	AGCCTCACCTCTACATCCCCT	0.587		NaN											0	0	0	0.004482	0	9	99									
FTSJ3	117246	broad.mit.edu	37	17	61897650	61897650	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:61897650T>C	uc002jbz.2	-	18	2299	c.2221A>G	c.(2221-2223)AAG>GAG	p.K741E	FTSJ3_uc002jca.2_Missense_Mutation_p.K741E	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	741					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						TCAGCCACCTTCTTGATGGGA	0.562		NaN											0	0	0	0.004482	0	8	105									
ABCA8	10351	broad.mit.edu	37	17	66937049	66937049	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:66937049G>A	uc002jhp.2	-	3	330	c.151C>T	c.(151-153)CAT>TAT	p.H51Y	ABCA8_uc002jhq.2_Missense_Mutation_p.H51Y|ABCA8_uc010wqq.1_Missense_Mutation_p.H51Y|ABCA8_uc010wqr.1_5'UTR|ABCA8_uc002jhr.2_Missense_Mutation_p.H51Y|ABCA8_uc002jhs.2_Missense_Mutation_p.H51Y|ABCA8_uc002jht.2_Missense_Mutation_p.H51Y	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	51						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					TTTACTTGATGACTATGAGGA	0.323		NaN											0	0	0	0.004672	0	3	30									
ABCA9	10350	broad.mit.edu	37	17	67045523	67045523	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:67045523C>T	uc002jhu.2	-	3	348	c.205G>A	c.(205-207)GAT>AAT	p.D69N	ABCA9_uc010dez.2_Missense_Mutation_p.D69N|ABCA9_uc002jhv.2_Missense_Mutation_p.D69N	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	69					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					TTAAAACTATCTACACGTCCC	0.363		NaN											0	0	0	0.020292	0	14	85									
ABCA10	10349	broad.mit.edu	37	17	67189995	67189995	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:67189995G>T	uc010dfa.1	-	14	2360	c.1481C>A	c.(1480-1482)GCT>GAT	p.A494D	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Missense_Mutation_p.A95D	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	494	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TTTTATTTTAGCAAATACCCT	0.328		NaN											1	0	9.70103e-10	0.008291	1.10054e-09	9	101									
FOXK2	3607	broad.mit.edu	37	17	80529635	80529635	+	Silent	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:80529635G>C	uc002kfn.2	+	4	969	c.798G>C	c.(796-798)CTG>CTC	p.L266L	FOXK2_uc002kfm.1_Silent_p.L266L|FOXK2_uc010diu.2_Silent_p.L266L	NM_004514	NP_004505	Q01167	FOXK2_HUMAN	forkhead box K2	266	Fork-head.				embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			ACGCGCAGCTGATAGTTCAGG	0.398		NaN											0	0	0	0.00308	0	7	52									
KIAA1012	22878	broad.mit.edu	37	18	29511315	29511315	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr18:29511315C>T	uc002kxc.3	-	2	693	c.329G>A	c.(328-330)GGA>GAA	p.G110E	KIAA1012_uc002kxb.3_Missense_Mutation_p.G56E|KIAA1012_uc002kxd.3_RNA|KIAA1012_uc002kxe.2_Missense_Mutation_p.G110E	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	110					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						GTCATAATCTCCTGCTGTAAT	0.408		NaN											0	0	0	0.010729	0	10	94									
RIT2	6014	broad.mit.edu	37	18	40323522	40323522	+	Missense_Mutation	SNP	C	C	G	rs77976328		TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr18:40323522C>G	uc002lav.2	-	5	763	c.590G>C	c.(589-591)AGA>ACA	p.R197T	RIT2_uc010dnf.2_3'UTR	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	197					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						GCTGTCTTTTCTCTTCAGTTT	0.413		NaN											0	0	0	0.021523	0	23	152									
TMEM146	257062	broad.mit.edu	37	19	5772930	5772930	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:5772930C>A	uc002mda.2	+	20	1956	c.1895C>A	c.(1894-1896)ACC>AAC	p.T632N		NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	632	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						CAGAACTGGACCACCATGATA	0.567		NaN											1	0	0.00024832	0.009096	0.000262927	3	40									
MYO9B	4650	broad.mit.edu	37	19	17263473	17263473	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:17263473C>G	uc010eak.2	+	4	1107	c.955C>G	c.(955-957)CTG>GTG	p.L319V	MYO9B_uc002nfi.2_Missense_Mutation_p.L319V|MYO9B_uc002nfj.1_Missense_Mutation_p.L319V	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	319	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						CGAGAAATATCTGCTTGAAAA	0.368		NaN											0	0	0	0.021553	0	4	35									
ZNF536	9745	broad.mit.edu	37	19	31039753	31039753	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:31039753C>G	uc002nsu.1	+	4	3365	c.3227C>G	c.(3226-3228)TCT>TGT	p.S1076C	ZNF536_uc010edd.1_Missense_Mutation_p.S1076C	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1076					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GACTCTGCTTCTGAGAAGATG	0.552		NaN											0	0	0	0.00308	0	8	61									
KIAA0355	9710	broad.mit.edu	37	19	34832940	34832940	+	Missense_Mutation	SNP	C	C	T	rs144261536		TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:34832940C>T	uc002nvd.3	+	10	2960	c.2101C>T	c.(2101-2103)CGG>TGG	p.R701W		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	701										ovary(1)	1	Esophageal squamous(110;0.162)					CCCTCCACCACGGGCACCCCA	0.612		NaN											0	0	0	0.004482	0	8	94									
CIC	23152	broad.mit.edu	37	19	42793047	42793047	+	Silent	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:42793047T>C	uc002otf.1	+	7	979	c.939T>C	c.(937-939)TCT>TCC	p.S313S		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				CAGTGTCCTCTGAGCTCCTGT	0.562		NaN	T	DUX4	soft tissue sarcoma								0	0	0	0.028581	0	5	42									
CIC	23152	broad.mit.edu	37	19	42793049	42793049	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:42793049A>T	uc002otf.1	+	7	981	c.941A>T	c.(940-942)GAG>GTG	p.E314V		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				GTGTCCTCTGAGCTCCTGTCC	0.557		NaN	T	DUX4	soft tissue sarcoma								0	0	0	0.024245	0	4	44									
XRCC1	7515	broad.mit.edu	37	19	44079154	44079154	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:44079154T>C	uc002owt.2	-	2	172	c.52A>G	c.(52-54)ACT>GCT	p.T18A	XRCC1_uc010xwp.1_Intron|uc010xwq.1_5'Flank	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	18					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				GCACAGTGAGTCTGGAAACAA	0.527		NaN						Other_BER_factors					0	0	0	0.021553	0	6	26									
ZNF283	284349	broad.mit.edu	37	19	44352248	44352249	+	Missense_Mutation	DNP	GG	GG	TC			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:44352248_44352249GG>TC	uc002oxr.3	+	7	1763_1764	c.1495_1496GG>TC	c.(1495-1497)GGG>TCG	p.G499S	ZNF283_uc002oxp.3_Missense_Mutation_p.G360S	NM_181845	NP_862828	Q8N7M2	ZN283_HUMAN	zinc finger protein 283	499	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				CTTTTGTAGTGGGTATCAACTT	0.411		NaN											0	0	0	0.004672	0	21	101									
ERCC2	2068	broad.mit.edu	37	19	45855835	45855835	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:45855835G>A	uc002pbj.2	-	21	2022	c.1975C>T	c.(1975-1977)CAC>TAC	p.H659Y	ERCC2_uc002pbh.2_Missense_Mutation_p.H222Y|ERCC2_uc002pbi.2_Missense_Mutation_p.H352Y|ERCC2_uc010ejz.2_Missense_Mutation_p.H581Y|ERCC2_uc002pbk.2_Missense_Mutation_p.H635Y	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	659					cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		TGGGCCGCGTGGCGCATGGCA	0.612		NaN	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.006122	0	19	57									
PTGIR	5739	broad.mit.edu	37	19	47124901	47124901	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:47124901G>C	uc002pex.2	-	3	910	c.797C>G	c.(796-798)CCT>CGT	p.P266R		NM_000960	NP_000951	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	266	Extracellular (Potential).				cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	GCTGCTGTCAGGGGCGACAGC	0.642		NaN											0	0	0	0.008291	0	10	32									
ALDH16A1	126133	broad.mit.edu	37	19	49967904	49967904	+	Silent	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:49967904C>T	uc002pnt.2	+	12	1569	c.1453C>T	c.(1453-1455)CTG>TTG	p.L485L	ALDH16A1_uc010yar.1_Silent_p.L434L|ALDH16A1_uc010yas.1_Silent_p.L320L|ALDH16A1_uc010yat.1_Silent_p.L322L	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	485							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		GTATGAGTATCTGCGGCCCTC	0.662		NaN											0	0	0	0.004482	0	9	137									
ZNF468	90333	broad.mit.edu	37	19	53352431	53352431	+	Silent	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:53352431G>A	uc002qaf.2	-	3	202	c.51C>T	c.(49-51)TTC>TTT	p.F17F	ZNF468_uc002qae.2_5'UTR	NM_001008801	NP_001008801	Q5VIY5	ZN468_HUMAN	zinc finger protein ZNF468 isoform 2	17	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0358)		CCTCCTGAGAGAATTCTATGG	0.443		NaN											0	0	0	0.00308	0	7	158									
ZNF160	90338	broad.mit.edu	37	19	53573254	53573254	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:53573254T>C	uc010eqk.2	-	7	949	c.533A>G	c.(532-534)AAC>AGC	p.N178S	ZNF160_uc002qaq.3_Missense_Mutation_p.N178S|ZNF160_uc002qar.3_Missense_Mutation_p.N178S	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	178					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		AAGCTGATTGTTCATAAGCTT	0.413		NaN											0	0	0	0.021553	0	5	146									
CACNG6	59285	broad.mit.edu	37	19	54502980	54502980	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:54502980G>A	uc002qct.2	+	3	1089	c.499G>A	c.(499-501)GCA>ACA	p.A167T	CACNG6_uc002qcu.2_Intron|CACNG6_uc002qcv.2_Intron	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	167						voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		CAGTAAAGGTGCAGAGTTCCT	0.592		NaN											0	0	0	0.021553	0	6	178									
PRPF31	26121	broad.mit.edu	37	19	54632680	54632681	+	Missense_Mutation	DNP	GG	GG	CC			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:54632680_54632681GG>CC	uc002qdh.2	+	13	1705_1706	c.1309_1310GG>CC	c.(1309-1311)GGG>CCG	p.G437P	PRPF31_uc010yek.1_Missense_Mutation_p.R414P	NM_015629	NP_056444	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31 homolog	437					assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CGTATATGGCGGGAAGTCCACC	0.619		NaN									OREG0003636	type=REGULATORY REGION|Gene=AK091105|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.004672	0	3	11									
PTPRH	5794	broad.mit.edu	37	19	55696892	55696892	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:55696892C>T	uc002qjq.2	-	18	3113	c.3040G>A	c.(3040-3042)GGC>AGC	p.G1014S	PTPRH_uc010esv.2_Missense_Mutation_p.G836S	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	1014	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		ATGGGTGGGCCTCCCTCCATG	0.632		NaN											0	0	0	0.004672	0	3	18									
HSPBP1	23640	broad.mit.edu	37	19	55776711	55776711	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:55776711C>A	uc002qjx.2	-	6	1188	c.1078G>T	c.(1078-1080)GAA>TAA	p.E360*	HSPBP1_uc002qjy.2_Nonsense_Mutation_p.E314*|HSPBP1_uc002qkb.2_Missense_Mutation_p.G310V|HSPBP1_uc002qka.2_Nonsense_Mutation_p.E314*|HSPBP1_uc002qkd.2_Nonsense_Mutation_p.E314*|HSPBP1_uc002qkc.2_Nonsense_Mutation_p.E314*|uc002qke.2_5'Flank	NM_012267	NP_036399	Q9NZL4	HPBP1_HUMAN	hsp70-interacting protein	317					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		AGGCCCAGTTCCGGCTCCCGA	0.647		NaN											1	0	0.000157383	0.00308	0.000167958	7	93									
APOB	338	broad.mit.edu	37	2	21228278	21228278	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:21228278G>C	uc002red.2	-	26	11590	c.11462C>G	c.(11461-11463)ACT>AGT	p.T3821S		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3821					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTGGGACACAGTTAACTGAGA	0.423		NaN											0	0	0	0.014758	0	4	167									
APOB	338	broad.mit.edu	37	2	21249677	21249677	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:21249677C>T	uc002red.2	-	15	2355	c.2227G>A	c.(2227-2229)GAT>AAT	p.D743N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	743					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGTTTATCATCTTTGGTATAG	0.393		NaN											0	0	0	0.02938	0	7	93									
SMYD1	150572	broad.mit.edu	37	2	88387407	88387407	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:88387407T>G	uc002ssr.2	+	3	343	c.341T>G	c.(340-342)GTG>GGG	p.V114G	SMYD1_uc002ssq.1_Intron	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						ATGTGGCGGGTGGAGAGAGAA	0.542		NaN											0	0	0	0.021553	0	3	3									
DARS	1615	broad.mit.edu	37	2	136673932	136673932	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:136673932C>T	uc002tux.1	-	11	1154	c.970G>A	c.(970-972)GAA>AAA	p.E324K	DARS_uc010fnj.1_Missense_Mutation_p.E224K	NM_001349	NP_001340	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	324					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	GTTTGAATTTCAGTCTGAAAC	0.348		NaN											0	0	0	0.00308	0	7	87									
THSD7B	80731	broad.mit.edu	37	2	138320875	138320875	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:138320875G>C	uc002tva.1	+	15	3136	c.3136G>C	c.(3136-3138)GAG>CAG	p.E1046Q	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		AATCAACAATGAGCTGAGGTC	0.453		NaN											0	0	0	0.009096	0	4	24									
ZEB2	9839	broad.mit.edu	37	2	145147516	145147516	+	Silent	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:145147516G>A	uc002tvu.2	-	10	3627	c.3147C>T	c.(3145-3147)CAC>CAT	p.H1049H	ZEB2_uc002tvv.2_Silent_p.H1043H|ZEB2_uc010zbm.1_Silent_p.H1020H|ZEB2_uc010fnp.2_Intron	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	1049	C2H2-type 6.					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCTCGCCCGAGTGAAGCCTTG	0.478		NaN											0	0	0	0.00308	0	8	49									
KCNH7	90134	broad.mit.edu	37	2	163236421	163236421	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:163236421C>G	uc002uch.1	-	14	3285	c.3073G>C	c.(3073-3075)GAC>CAC	p.D1025H		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	1025	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TAGGTGAGGTCGCTTTCGGTT	0.517		NaN											0	0	0	0.013537	0	12	154									
LRP2	4036	broad.mit.edu	37	2	170009322	170009322	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:170009322C>A	uc002ues.2	-	67	12661	c.12448G>T	c.(12448-12450)GAC>TAC	p.D4150Y		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4150	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCAACCCAGTCCACTGCTATT	0.478		NaN											1	0	0.00010058	0.013537	0.000108194	13	137									
HNRNPA3	220988	broad.mit.edu	37	2	178082493	178082493	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:178082493C>T	uc002ulb.1	+	8	987	c.881C>T	c.(880-882)CCA>CTA	p.P294L	HNRNPA3_uc002ulc.1_Missense_Mutation_p.P294L|HNRNPA3_uc002uld.2_Missense_Mutation_p.P272L|HNRNPA3_uc002ule.2_Missense_Mutation_p.P71L	NM_194247	NP_919223	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3	294	Gly-rich.					catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			ovary(2)	2						GGTGGTGGACCAGGATATGGA	0.438		NaN											0	0	0	0.006214	0	10	120									
CASP8	841	broad.mit.edu	37	2	202131238	202131238	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:202131238T>C	uc002uxr.1	+	3	238	c.29T>C	c.(28-30)ATT>ACT	p.I10T	CASP8_uc010ftc.1_Missense_Mutation_p.I10T|CASP8_uc002uxo.1_Missense_Mutation_p.I10T|CASP8_uc002uxp.1_Missense_Mutation_p.I10T|CASP8_uc002uxq.1_Missense_Mutation_p.I10T|CASP8_uc002uxs.1_Missense_Mutation_p.I10T|CASP8_uc002uxt.1_Missense_Mutation_p.I69T|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Missense_Mutation_p.I10T|CASP8_uc002uxw.1_Missense_Mutation_p.I10T|CASP8_uc002uxy.1_Missense_Mutation_p.I10T|CASP8_uc002uxx.1_Missense_Mutation_p.I10T|CASP8_uc010ftf.2_Missense_Mutation_p.I10T	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	10	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						CTTTATGATATTGGGGAACAA	0.408		NaN								HNSCC(4;0.00038)			0	0	0	0.02938	0	6	60									
SCLY	51540	broad.mit.edu	37	2	238999877	238999877	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:238999877G>A	uc010fyv.2	+	8	967	c.903G>A	c.(901-903)ATG>ATA	p.M301I	SCLY_uc002vxm.3_Missense_Mutation_p.M268I|SCLY_uc002vxn.2_Missense_Mutation_p.M301I|SCLY_uc010znq.1_Intron|SCLY_uc010znr.1_Missense_Mutation_p.M207I	NM_016510	NP_057594	Q96I15	SCLY_HUMAN	selenocysteine lyase	301					cellular amino acid metabolic process	cytosol	pyridoxal phosphate binding|selenocysteine lyase activity|transferase activity			ovary(2)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;1.37e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.6e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.25e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000128)|Lung(119;0.0118)|LUSC - Lung squamous cell carcinoma(224;0.0285)		ACACCCCAATGATTGCTGGCC	0.463		NaN											0	0	0	0.024245	0	10	111									
PDYN	5173	broad.mit.edu	37	20	1961214	1961214	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr20:1961214G>A	uc010gaj.2	-	3	762	c.520C>T	c.(520-522)CGC>TGC	p.R174C	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.R174C|PDYN_uc010zpt.1_Missense_Mutation_p.R19C	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	174					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						CCCCCATAGCGTTTGACCTGC	0.582		NaN											0	0	0	0.021553	0	6	81									
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr20:33345744C>T	uc002xav.2	-	8	3378	c.807G>A	c.(805-807)CAG>CAA	p.Q269Q	NCOA6_uc002xaw.2_Silent_p.Q269Q|NCOA6_uc010gew.1_Silent_p.Q226Q	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						gctgctgctgctgttgttgtt	0.313		NaN											0	0	0	0.004672	0	3	18									
ZHX3	23051	broad.mit.edu	37	20	39832810	39832810	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr20:39832810G>T	uc002xjs.1	-	3	1125	c.747C>A	c.(745-747)AAC>AAA	p.N249K	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Missense_Mutation_p.N249K|ZHX3_uc002xjt.1_Missense_Mutation_p.N249K|ZHX3_uc002xju.1_Missense_Mutation_p.N249K|ZHX3_uc002xjv.1_Missense_Mutation_p.N249K|ZHX3_uc002xjw.1_Missense_Mutation_p.N249K|ZHX3_uc010ggg.1_Missense_Mutation_p.N249K	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	249	Required for homodimerization and interaction with NFYA.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				CGGCATGGGGGTTTTTTGCAG	0.587		NaN											1	0	0.00116845	0.021553	0.00121807	6	68									
TSHZ2	128553	broad.mit.edu	37	20	51870547	51870547	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr20:51870547C>T	uc002xwo.2	+	2	1506	c.550C>T	c.(550-552)CGG>TGG	p.R184W		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	184					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			CTTGCCTTCTCGGTCCGTCTC	0.552		NaN											0	0	0	0.009096	0	4	41									
IL10RB	3588	broad.mit.edu	37	21	34648997	34648997	+	Silent	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr21:34648997G>A	uc002yrk.1	+	3	369	c.270G>A	c.(268-270)AGG>AGA	p.R90R	IL10RB_uc002yrh.1_Silent_p.R160R|IL10RB_uc002yri.1_Silent_p.R43R|IL10RB_uc002yrl.1_Silent_p.R92R	NM_000628	NP_000619	Q08334	I10R2_HUMAN	interleukin 10 receptor, beta precursor	90	Extracellular (Potential).				immune response|inflammatory response	interleukin-28 receptor complex	protein binding|receptor activity				0						TGAGAGTCAGGGCTGAATTTG	0.398		NaN											0	0	0	0.010729	0	11	148									
KCNJ15	3772	broad.mit.edu	37	21	39671406	39671406	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr21:39671406G>A	uc002ywv.2	+	4	525	c.223G>A	c.(223-225)GTG>ATG	p.V75M	KCNJ15_uc002yww.2_Missense_Mutation_p.V75M|KCNJ15_uc002ywx.2_Missense_Mutation_p.V75M	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	75	Helical; Name=M1; (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6						TGCCACTTTTGTGATGACCTG	0.473		NaN											0	0	0	0.00308	0	7	88									
ERG	2078	broad.mit.edu	37	21	39755633	39755633	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr21:39755633T>C	uc010gnw.2	-	12	1448	c.1153A>G	c.(1153-1155)ATG>GTG	p.M385V	ERG_uc002yxa.2_Missense_Mutation_p.M378V|ERG_uc011aek.1_Missense_Mutation_p.M286V|ERG_uc010gnv.2_Missense_Mutation_p.M262V|ERG_uc010gnx.2_Missense_Mutation_p.M361V|ERG_uc011ael.1_Missense_Mutation_p.M385V|ERG_uc002yxb.2_Missense_Mutation_p.M361V	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	385	ETS.				cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				ACCTTGGTCATGATGTTCTTG	0.592		NaN											0	0	0	0.008291	0	10	85									
GAB4	128954	broad.mit.edu	37	22	17447085	17447085	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:17447085G>C	uc002zlw.2	-	6	1301	c.1193C>G	c.(1192-1194)TCC>TGC	p.S398C	GAB4_uc010gqs.1_3'UTR	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	398										large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				TGTGAGTGGGGAGCCAAGCAG	0.592		NaN											0	0	0	0.00308	0	8	57									
ZNF74	7625	broad.mit.edu	37	22	20749694	20749694	+	Missense_Mutation	SNP	G	G	A	rs139227842	by1000genomes	TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:20749694G>A	uc010gsm.2	+	3	318	c.106G>A	c.(106-108)GAA>AAA	p.E36K	ZNF74_uc002zsg.2_5'UTR|ZNF74_uc002zsh.2_Missense_Mutation_p.E36K|ZNF74_uc002zsi.2_Intron|ZNF74_uc010gsn.2_5'UTR	NM_003426	NP_003417	Q16587	ZNF74_HUMAN	zinc finger protein 74	36					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GGGTCTTCCCGAAGCCAGGTC	0.532		NaN											0	0	0	0.009096	0	4	57									
EWSR1	2130	broad.mit.edu	37	22	29695597	29695597	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:29695597C>T	uc003aet.2	+	16	2015	c.1687C>T	c.(1687-1689)CGT>TGT	p.R563C	EWSR1_uc003aev.2_Missense_Mutation_p.R568C|EWSR1_uc003aew.2_Missense_Mutation_p.R507C|EWSR1_uc003aex.2_Missense_Mutation_p.R562C|EWSR1_uc003aey.2_Missense_Mutation_p.R358C|EWSR1_uc003aez.2_Missense_Mutation_p.R224C	NM_005243	NP_005234	Q01844	EWS_HUMAN	Ewing sarcoma breakpoint region 1 isoform 2	563	Arg/Gly/Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/FLI1(2266)|EWSR1/ATF1(323)|EWSR1/WT1(231)|EWSR1/ERG(162)|EWSR1/NR4A3(140)|EWSR1/DDIT3(43)|EWSR1/CREB1(42)|EWSR1/FEV(10)|EWSR1/POU5F1(10)|EWSR1/ETV1(7)|EWSR1/ETV4(6)|EWSR1/ZNF384(4)|EWSR1/PBX1(3)|EWSR1/SP3(3)|EWSR1/PATZ1(2)	bone(2526)|soft_tissue(702)|skin(8)|autonomic_ganglia(4)|haematopoietic_and_lymphoid_tissue(4)|salivary_gland(2)|central_nervous_system(2)|NS(2)|pancreas(2)|lung(1)|ovary(1)	3254						AGGTGGTGATCGTGGCAGAGG	0.607		NaN	T	FLI1|ERG|ZNF278|NR4A3|FEV|ATF1|ETV1|ETV4|WT1|ZNF384|CREB1|POU5F1| PBX1	Ewing sarcoma| desmoplastic small round cell tumor |ALL|clear cell sarcoma|sarcoma|myoepithelioma								0	0	0	0.014758	0	3	33									
NF2	4771	broad.mit.edu	37	22	30057255	30057255	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:30057255C>T	uc003age.3	+	8	1180	c.737C>T	c.(736-738)CCT>CTT	p.P246L	NF2_uc003afy.3_Missense_Mutation_p.P246L|NF2_uc003afz.3_Missense_Mutation_p.P163L|NF2_uc003agf.3_Missense_Mutation_p.P246L|NF2_uc003agb.3_Missense_Mutation_p.P169L|NF2_uc003agc.3_Missense_Mutation_p.P208L|NF2_uc003agd.3_RNA|NF2_uc003agg.3_Missense_Mutation_p.P246L|NF2_uc003aga.3_Missense_Mutation_p.P204L|NF2_uc003agh.3_Missense_Mutation_p.P205L|NF2_uc003agi.3_Missense_Mutation_p.P163L|NF2_uc003agj.3_Intron|NF2_uc003agk.3_Missense_Mutation_p.P208L	NM_000268	NP_000259	P35240	MERL_HUMAN	neurofibromin 2 isoform 1	246	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.P246fs*5(2)|p.?(1)|p.N226_E270del(1)|p.D245fs*31(1)|p.L127_D382del(1)|p.L140_P252del(1)		meninges(372)|soft_tissue(284)|central_nervous_system(20)|kidney(10)|pleura(9)|skin(7)|large_intestine(5)|breast(5)|urinary_tract(3)|thyroid(2)|endometrium(2)|ovary(2)|lung(2)|stomach(2)|bone(2)|pituitary(1)	728						ATTTATGACCCTGAGAACAGA	0.502		NaN	D|Mis|N|F|S|O		meningioma|acoustic neuroma|renal 	meningioma|acoustic neuroma			Neurofibromatosis_type_2				0	0	0	0.010729	0	11	114									
APOL1	8542	broad.mit.edu	37	22	36661781	36661781	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:36661781C>T	uc003apf.2	+	6	1067	c.899C>T	c.(898-900)TCA>TTA	p.S300L	APOL1_uc011amn.1_Missense_Mutation_p.S177L|APOL1_uc003apc.2_RNA|APOL1_uc003ape.2_Missense_Mutation_p.S316L|APOL1_uc011amo.1_Missense_Mutation_p.S177L|APOL1_uc011amp.1_Missense_Mutation_p.S300L|APOL1_uc011amq.1_Missense_Mutation_p.S282L|APOL1_uc010gwx.2_Missense_Mutation_p.S177L	NM_003661	NP_003652	O14791	APOL1_HUMAN	apolipoprotein L1 isoform a precursor	300					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|ovary(1)	3						CCGCATGCCTCAGCCTCACGC	0.557		NaN											0	0	0	0.00308	0	7	60									
FAM83F	113828	broad.mit.edu	37	22	40415261	40415261	+	Silent	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:40415261C>T	uc003ayk.1	+	2	673	c.579C>T	c.(577-579)TAC>TAT	p.Y193Y		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	hypothetical protein LOC113828	193										breast(1)	1						TCCCAGTGTACATCATCCTGG	0.542		NaN											0	0	0	0.024245	0	12	50									
TCF20	6942	broad.mit.edu	37	22	42609633	42609633	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:42609633G>A	uc003bcj.1	-	1	1813	c.1679C>T	c.(1678-1680)CCG>CTG	p.P560L	TCF20_uc003bck.1_Missense_Mutation_p.P560L|TCF20_uc003bnt.2_Missense_Mutation_p.P560L	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						ACCTTGTGCCGGTGAGGAGCC	0.577		NaN											0	0	0	0.0333	0	18	82									
CELSR1	9620	broad.mit.edu	37	22	46759909	46759909	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:46759909C>T	uc003bhw.1	-	34	9019	c.9019G>A	c.(9019-9021)GAT>AAT	p.D3007N		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	3007	Cytoplasmic (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCGGAGCCATCGGCCTGGGCG	0.672		NaN											0	0	0	0.004482	0	7	14									
PLXNB2	23654	broad.mit.edu	37	22	50718479	50718479	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:50718479C>A	uc003bkv.3	-	26	4303	c.4197G>T	c.(4195-4197)AGG>AGT	p.R1399S	PLXNB2_uc003bkt.1_Missense_Mutation_p.R191S|PLXNB2_uc003bku.1_Missense_Mutation_p.R384S	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1399	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGGACAGCATCCTCTCCACCA	0.612		NaN											1	0	1.23904e-05	0.014758	1.35442e-05	5	38									
ATP2B2	491	broad.mit.edu	37	3	10370803	10370803	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr3:10370803C>T	uc003bvt.2	-	23	3866	c.3427G>A	c.(3427-3429)GTC>ATC	p.V1143I	ATP2B2_uc003bvv.2_Missense_Mutation_p.V1098I|ATP2B2_uc003bvw.2_Missense_Mutation_p.V1098I|ATP2B2_uc003bvs.2_RNA|ATP2B2_uc010hdo.2_Missense_Mutation_p.V848I|hsa-mir-378b|MI0014154_5'Flank	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	1143	Calmodulin-binding subdomain B (By similarity).|Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GCCTTCACGACGCGGATCTGC	0.582		NaN											0	0	0	0.009096	0	4	57									
TRIM71	131405	broad.mit.edu	37	3	32927521	32927521	+	Silent	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr3:32927521G>A	uc003cff.2	+	3	1179	c.1116G>A	c.(1114-1116)AAG>AAA	p.K372K		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	372					multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						CGAGGCATAAGAAAGCCCTGG	0.617		NaN											0	0	0	0.014758	0	5	39									
SLC22A13	9390	broad.mit.edu	37	3	38318947	38318947	+	Silent	SNP	A	A	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr3:38318947A>G	uc003chz.3	+	10	1701	c.1647A>G	c.(1645-1647)ACA>ACG	p.T549T		NM_004256	NP_004247	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion	549	Cytoplasmic (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		TGAGCAGCACATACTTCTGAT	0.562		NaN											0	0	0	0.021553	0	6	67									
CCDC36	339834	broad.mit.edu	37	3	49294677	49294677	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr3:49294677G>A	uc003cwk.2	+	10	2134	c.1747G>A	c.(1747-1749)GAC>AAC	p.D583N	CCDC36_uc011bck.1_Missense_Mutation_p.D583N	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	583										ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		TTTGCTCTATGACCTGGGTTT	0.488		NaN											0	0	0	0.013537	0	13	118									
HSPBAP1	79663	broad.mit.edu	37	3	122459659	122459659	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr3:122459659C>T	uc003efu.1	-	8	1123	c.1000G>A	c.(1000-1002)GAT>AAT	p.D334N	HSPBAP1_uc003eft.1_Missense_Mutation_p.D45N	NM_024610	NP_078886	Q96EW2	HBAP1_HUMAN	Hspb associated protein 1	334						cytoplasm				ovary(1)|lung(1)	2				GBM - Glioblastoma multiforme(114;0.0531)		CTGCAGCGATCAAAAAATGCA	0.403		NaN											0	0	0	0.013537	0	11	131									
KCNAB1	7881	broad.mit.edu	37	3	156234066	156234066	+	Silent	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr3:156234066C>T	uc003far.2	+	11	937	c.873C>T	c.(871-873)GGC>GGT	p.G291G	KCNAB1_uc011bon.1_Silent_p.G262G|KCNAB1_uc003fas.2_Silent_p.G280G|KCNAB1_uc003fat.2_Silent_p.G273G|KCNAB1_uc010hvt.1_Silent_p.G244G|KCNAB1_uc011boo.1_Silent_p.G167G	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related	291						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TAGGTGTTGGCGCAATGACAT	0.453		NaN											0	0	0	0.014758	0	5	45									
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.00308	0	6	38									
NOP14	8602	broad.mit.edu	37	4	2950082	2950082	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:2950082C>G	uc003ggj.1	-	9	1408	c.1336G>C	c.(1336-1338)GAG>CAG	p.E446Q	C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Missense_Mutation_p.E192Q|NOP14_uc003ggk.3_Missense_Mutation_p.E446Q|NOP14_uc003ggl.2_Missense_Mutation_p.E446Q	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	446					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						AAAAGCTGCTCTTCCATCGAT	0.413		NaN											0	0	0	0.006214	0	10	88									
UGDH	7358	broad.mit.edu	37	4	39523129	39523129	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:39523129A>G	uc003guk.1	-	2	320	c.4T>C	c.(4-6)TTT>CTT	p.F2L	UGDH_uc011byp.1_Intron|UGDH_uc003gul.1_Missense_Mutation_p.F2L	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	2					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	TTAATTTCAAACATGATTGTA	0.333		NaN											0	0	0	0.004672	0	3	58									
SLC30A9	10463	broad.mit.edu	37	4	42069148	42069148	+	Silent	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:42069148T>C	uc003gwl.2	+	14	1337	c.1191T>C	c.(1189-1191)GAT>GAC	p.D397D	SLC30A9_uc011byx.1_Silent_p.D157D	NM_006345	NP_006336	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter),	397	Helical; (Potential).				nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3						TATTGGAGGATACTGCTGCAG	0.353		NaN											0	0	0	0.021553	0	5	110									
UGT2B10	7365	broad.mit.edu	37	4	69692212	69692212	+	Silent	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:69692212C>T	uc003hee.2	+	4	1109	c.1084C>T	c.(1084-1086)CTA>TTA	p.L362L	UGT2B10_uc011cam.1_Silent_p.L278L	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	362					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GAATGACCTTCTAGGTAACAC	0.378		NaN											0	0	0	0.021553	0	5	63									
HSD17B13	345275	broad.mit.edu	37	4	88239530	88239530	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:88239530T>C	uc003hqo.2	-	2	332	c.269A>G	c.(268-270)TAT>TGT	p.Y90C	HSD17B13_uc010ikk.2_Intron	NM_178135	NP_835236	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	90						extracellular region	binding|oxidoreductase activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		GTCTACCACATACGCATGCGC	0.458		NaN											0	0	0	0.021553	0	6	62									
C4orf21	55345	broad.mit.edu	37	4	113468478	113468478	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:113468478C>G	uc003iau.2	-	24	5772	c.5561G>C	c.(5560-5562)GGA>GCA	p.G1854A	C4orf21_uc003iav.2_RNA|C4orf21_uc003iat.2_Missense_Mutation_p.G312A	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	676						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TTGTTCCAATCCATTTTCATG	0.373		NaN											0	0	0	0.004672	0	3	31									
SH3D19	152503	broad.mit.edu	37	4	152065152	152065152	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:152065152C>G	uc010ipl.1	-	13	2452	c.1362G>C	c.(1360-1362)GAG>GAC	p.E454D	SH3D19_uc003imb.2_Missense_Mutation_p.E209D|SH3D19_uc003imc.2_Missense_Mutation_p.E395D|SH3D19_uc003ime.2_Missense_Mutation_p.E431D|SH3D19_uc010ipm.2_Missense_Mutation_p.E431D	NM_001009555	NP_001009555	Q5HYK7	SH319_HUMAN	SH3 domain containing 19 isoform a	454	SH3 1.				cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	cytosol|Golgi apparatus|nucleus|plasma membrane	proline-rich region binding			ovary(1)|skin(1)	2	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				CCTTTTGGCACTCCAAGTAAT	0.398		NaN											0	0	0	0.009096	0	4	55									
FBXW7	55294	broad.mit.edu	37	4	153247366	153247366	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:153247366C>G	uc003ims.2	-	10	1585	c.1436G>C	c.(1435-1437)CGA>CCA	p.R479P	FBXW7_uc011cii.1_Missense_Mutation_p.R479P|FBXW7_uc003imt.2_Missense_Mutation_p.R479P|FBXW7_uc011cih.1_Missense_Mutation_p.R303P|FBXW7_uc003imq.2_Missense_Mutation_p.R399P|FBXW7_uc003imr.2_Missense_Mutation_p.R361P	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	479	WD 3.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R479Q(31)|p.R479L(7)|p.R479G(3)|p.R399Q(2)|p.R240L(1)|p.R399L(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGTGGCATCTCGAGAACCGCT	0.403		NaN	Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.014758	0	5	59									
GUCY1B3	2983	broad.mit.edu	37	4	156715077	156715077	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:156715077G>C	uc003ipc.2	+	6	732	c.565G>C	c.(565-567)GAG>CAG	p.E189Q	GUCY1B3_uc011cio.1_Missense_Mutation_p.E211Q|GUCY1B3_uc011cip.1_Missense_Mutation_p.E169Q|GUCY1B3_uc003ipd.2_Missense_Mutation_p.E117Q|GUCY1B3_uc010iqf.2_Missense_Mutation_p.E189Q|GUCY1B3_uc010iqg.2_Missense_Mutation_p.E117Q|GUCY1B3_uc011ciq.1_Missense_Mutation_p.E117Q	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	189					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		GTCAAAAGAAGAGGATTTTTA	0.333		NaN											0	0	0	0.014758	0	5	53									
FAT1	2195	broad.mit.edu	37	4	187541654	187541654	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:187541654G>T	uc003izf.2	-	10	6274	c.6086C>A	c.(6085-6087)TCA>TAA	p.S2029*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2029	Extracellular (Potential).|Cadherin 18.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CAGAACTCCTGAAGTGCGGCT	0.463		NaN								HNSCC(5;0.00058)			1	0	9.57634e-11	0.01892	1.0956e-10	23	219									
ADAMTS12	81792	broad.mit.edu	37	5	33624410	33624410	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:33624410C>T	uc003jia.1	-	14	2232	c.2069G>A	c.(2068-2070)CGC>CAC	p.R690H	ADAMTS12_uc010iuq.1_Intron	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	690	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CACACCGCAGCGATCCTCGGT	0.502		NaN								HNSCC(64;0.19)			0	0	0	0.014758	0	5	49									
JMY	133746	broad.mit.edu	37	5	78610358	78610358	+	Silent	SNP	T	T	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:78610358T>G	uc003kfx.3	+	9	2863	c.2343T>G	c.(2341-2343)CCT>CCG	p.P781P	JMY_uc003kfw.1_Silent_p.P427P	NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	781	Pro-rich.				'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		CTGAACTGCCTCCCACTATAT	0.403		NaN											0	0	0	0.00308	0	6	103									
RASGRF2	5924	broad.mit.edu	37	5	80390805	80390805	+	Silent	SNP	C	C	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:80390805C>A	uc003kha.1	+	12	1749	c.1749C>A	c.(1747-1749)ATC>ATA	p.I583I	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	583	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TGAGTGACATCAGTCAGGTAA	0.393		NaN											1	0	2.0095e-06	0.02938	2.22362e-06	6	37									
TRIM36	55521	broad.mit.edu	37	5	114499268	114499268	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:114499268C>T	uc003kqs.2	-	2	754	c.245G>A	c.(244-246)CGA>CAA	p.R82Q	TRIM36_uc011cwc.1_Missense_Mutation_p.R70Q|TRIM36_uc003kqt.2_Intron	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	82	RING-type; degenerate.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		GAGCCGAAGTCGAGGACTGCT	0.448		NaN											0	0	0	0.014758	0	5	63									
SLC12A2	6558	broad.mit.edu	37	5	127484463	127484463	+	Silent	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:127484463C>T	uc003kus.2	+	12	2063	c.1899C>T	c.(1897-1899)AAC>AAT	p.N633N	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Silent_p.N633N	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	633	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GTAAGGACAACATCTACCCAG	0.328		NaN											0	0	0	0.006214	0	10	112									
KDM3B	51780	broad.mit.edu	37	5	137756428	137756428	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:137756428A>G	uc003lcy.1	+	15	3949	c.3749A>G	c.(3748-3750)GAG>GGG	p.E1250G	KDM3B_uc010jew.1_Missense_Mutation_p.E906G|KDM3B_uc011cys.1_Missense_Mutation_p.E282G	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1250					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						CTCAATAAAGAGTCTCATTCA	0.483		NaN											0	0	0	0.010729	0	10	66									
PCDHB2	56133	broad.mit.edu	37	5	140475832	140475832	+	Silent	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:140475832C>G	uc003lil.2	+	1	1596	c.1458C>G	c.(1456-1458)GCC>GCG	p.A486A	PCDHB2_uc003lim.1_Silent_p.A147A	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	486	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCACCAACGCCCAGGTCACCT	0.662		NaN											0	0	0	0.013537	0	6	111									
C5orf58	133874	broad.mit.edu	37	5	169661182	169661182	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:169661182G>A	uc010jjn.2	+	2	126	c.43G>A	c.(43-45)GAG>AAG	p.E15K	C5orf58_uc003mal.2_RNA	NM_001102609	NP_001096079	C9J3I9	CE058_HUMAN	hypothetical protein LOC133874	15											0						GGAAAAGGTAGAGGCAAGGAT	0.393		NaN											0	0	0	0.004672	0	3	28									
ZNF346	23567	broad.mit.edu	37	5	176468221	176468221	+	Silent	SNP	A	A	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:176468221A>T	uc003mfi.2	+	2	313	c.270A>T	c.(268-270)GCA>GCT	p.A90A	ZNF346_uc011dfr.1_Silent_p.A90A|ZNF346_uc011dfs.1_Intron|ZNF346_uc003mfj.2_Intron|ZNF346_uc003mfk.1_Silent_p.A115A|ZNF346_uc011dft.1_Intron	NM_012279	NP_036411	Q9UL40	ZN346_HUMAN	zinc finger protein 346	90	Matrin-type 1.					cytoplasm|nucleolus	double-stranded RNA binding|zinc ion binding				0	all_cancers(89;6.3e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGAAGCTGGCACATTACCAGG	0.458		NaN											0	0	0	0.010729	0	12	110									
HIVEP1	3096	broad.mit.edu	37	6	12125108	12125108	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:12125108C>T	uc003nac.2	+	4	5259	c.5080C>T	c.(5080-5082)CAG>TAG	p.Q1694*	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1694					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AAAAGGTCATCAGAATGCTTT	0.393		NaN											0	0	0	0.028581	0	16	93									
GPLD1	2822	broad.mit.edu	37	6	24472819	24472819	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:24472819G>A	uc003ned.1	-	7	647	c.536C>T	c.(535-537)GCA>GTA	p.A179V	GPLD1_uc010jpr.1_Intron|GPLD1_uc010jps.1_Missense_Mutation_p.A179V	NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	179						extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						CCAGCGTCGTGCAAGGTAATT	0.338		NaN											0	0	0	0.013537	0	9	78									
GRM4	2914	broad.mit.edu	37	6	34003916	34003916	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:34003916G>C	uc003oir.3	-	8	2141	c.1971C>G	c.(1969-1971)ATC>ATG	p.I657M	GRM4_uc011dsn.1_Missense_Mutation_p.I610M|GRM4_uc010jvh.2_Missense_Mutation_p.I657M|GRM4_uc010jvi.2_Missense_Mutation_p.I349M|GRM4_uc003oio.2_Missense_Mutation_p.I349M|GRM4_uc003oip.2_RNA|GRM4_uc011dsl.1_Missense_Mutation_p.I517M|GRM4_uc003oiq.2_Missense_Mutation_p.I524M|GRM4_uc011dsm.1_Missense_Mutation_p.I488M	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	657	Helical; Name=3; (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	GTCCCAGGAAGATTCGGCGCA	0.602		NaN											0	0	0	0.014758	0	5	43									
TEAD3	7005	broad.mit.edu	37	6	35454253	35454253	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:35454253C>G	uc003oku.3	-	2	423	c.187G>C	c.(187-189)GAG>CAG	p.E63Q	TEAD3_uc010jvx.2_Silent_p.T45T	NM_003214	NP_003205	Q99594	TEAD3_HUMAN	TEA domain family member 3	63	TEA.				female pregnancy|hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ATCTTGCCCTCGTCTGACAGG	0.697		NaN											0	0	0	0.014758	0	5	40									
BRPF3	27154	broad.mit.edu	37	6	36168658	36168658	+	Silent	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:36168658C>T	uc003olv.3	+	2	783	c.559C>T	c.(559-561)CTG>TTG	p.L187L	BRPF3_uc010jwb.2_Silent_p.L187L|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Silent_p.L187L	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	187					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CTTTGAGCTGCTGGTAGACCG	0.527		NaN											0	0	0	0.014758	0	4	55									
PRPH2	5961	broad.mit.edu	37	6	42672298	42672298	+	Silent	SNP	G	G	A	rs61755799		TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:42672298G>A	uc003osk.2	-	2	919	c.633C>T	c.(631-633)TTC>TTT	p.F211F		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	211	Lumenal (Potential).		F -> L (in RP7).		cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			TGCAGCAGCTGAAAGGGACGC	0.562		NaN											0	0	0	0.014758	0	5	51									
GPR116	221395	broad.mit.edu	37	6	46849233	46849233	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:46849233G>A	uc003oyo.3	-	8	1062	c.773C>T	c.(772-774)ACC>ATC	p.T258I	GPR116_uc003oyp.3_Missense_Mutation_p.T258I|GPR116_uc003oyq.3_Missense_Mutation_p.T258I|GPR116_uc010jzi.1_5'Flank|GPR116_uc003oyr.2_Missense_Mutation_p.T258I	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	258	SEA.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			CATTTTGTAGGTCTGATTGAG	0.368		NaN											0	0	0	0.014758	0	5	66									
DST	667	broad.mit.edu	37	6	56401661	56401661	+	Silent	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:56401661C>T	uc003pdf.2	-	56	10357	c.10329G>A	c.(10327-10329)CAG>CAA	p.Q3443Q	DST_uc003pcz.3_Silent_p.Q3265Q|DST_uc011dxj.1_Silent_p.Q3294Q|DST_uc011dxk.1_Silent_p.Q3305Q|DST_uc003pcy.3_Silent_p.Q2939Q	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	5351	Spectrin 7.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGGCAGCACTCTGAATAAGGC	0.433		NaN											0	0	0	0.014758	0	5	62									
AKD1	221264	broad.mit.edu	37	6	109996891	109996891	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:109996891C>T	uc003ptn.2	-	2	135	c.58G>A	c.(58-60)GAA>AAA	p.E20K	AKD1_uc003ptr.3_Missense_Mutation_p.E20K|AKD1_uc003pts.1_RNA	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	20					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						CTTTCAGTTTCATCTTCATCA	0.289		NaN											0	0	0	0.009096	0	4	27									
TSPYL1	7259	broad.mit.edu	37	6	116600201	116600201	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:116600201G>C	uc003pwp.3	-	1	1080	c.793C>G	c.(793-795)CTG>GTG	p.L265V	DSE_uc011ebf.1_Intron|DSE_uc003pwq.1_5'Flank|DSE_uc003pwr.2_5'Flank|DSE_uc003pws.2_5'Flank	NM_003309	NP_003300	Q9H0U9	TSYL1_HUMAN	TSPY-like 1	265					nucleosome assembly	nucleolus					0		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.0235)|OV - Ovarian serous cystadenocarcinoma(136;0.0469)|GBM - Glioblastoma multiforme(226;0.0503)|Epithelial(106;0.094)		CTCCGCTCCAGGTAGTGTCGA	0.562		NaN											0	0	0	0.00308	0	8	84									
MAP3K5	4217	broad.mit.edu	37	6	136904781	136904781	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:136904781G>A	uc003qhc.2	-	24	3684	c.3323C>T	c.(3322-3324)ACC>ATC	p.T1108I	MAP3K5_uc011edj.1_Missense_Mutation_p.T355I|MAP3K5_uc011edk.1_Missense_Mutation_p.T954I	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	1108					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TGACAGTGTGGTGGCTATGAT	0.463		NaN											0	0	0	0.00308	0	8	67									
GET4	51608	broad.mit.edu	37	7	926266	926266	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr7:926266G>A	uc003sjl.1	+	3	387	c.295G>A	c.(295-297)GAG>AAG	p.E99K	GET4_uc003sjj.1_RNA	NM_015949	NP_057033	Q7L5D6	GET4_HUMAN	hypothetical protein LOC51608	99					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding				0						GGCGGAAGTGGAGGTGGCTGA	0.597		NaN											0	0	0	0.028581	0	15	67									
INTS1	26173	broad.mit.edu	37	7	1513805	1513805	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr7:1513805A>G	uc003skn.2	-	41	5929	c.5828T>C	c.(5827-5829)CTG>CCG	p.L1943P	INTS1_uc003skm.1_Missense_Mutation_p.L80P	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1943					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		AGCACACACCAGCAGCAGGCG	0.706		NaN									OREG0017827	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	13									
CHN2	1124	broad.mit.edu	37	7	29539546	29539546	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr7:29539546T>C	uc003szz.2	+	9	1240	c.803T>C	c.(802-804)CTC>CCC	p.L268P	CHN2_uc011jzs.1_Missense_Mutation_p.L343P|CHN2_uc010kva.2_Missense_Mutation_p.L38P|CHN2_uc010kvb.2_Intron|CHN2_uc010kvc.2_Missense_Mutation_p.L233P|CHN2_uc011jzt.1_Missense_Mutation_p.L281P|CHN2_uc010kvd.2_Missense_Mutation_p.L124P|CHN2_uc011jzu.1_Missense_Mutation_p.L253P|CHN2_uc010kvg.2_Missense_Mutation_p.L132P|CHN2_uc010kvh.2_Intron|CHN2_uc010kvi.2_Missense_Mutation_p.L132P|CHN2_uc010kve.2_Missense_Mutation_p.L132P|CHN2_uc003taa.2_Missense_Mutation_p.L132P|CHN2_uc010kvf.2_Intron|CHN2_uc010kvj.2_Missense_Mutation_p.L87P|CHN2_uc010kvk.2_Intron|CHN2_uc010kvl.2_RNA|CHN2_uc010kvm.2_Missense_Mutation_p.L87P|CHN2_uc011jzv.1_Missense_Mutation_p.L61P	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	268					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						CAACCTGATCTCAAGAGGATC	0.468		NaN											0	0	0	0.010729	0	12	46									
AOAH	313	broad.mit.edu	37	7	36571798	36571798	+	Silent	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr7:36571798G>A	uc003tfh.3	-	18	1781	c.1380C>T	c.(1378-1380)CAC>CAT	p.H460H	AOAH_uc010kxf.2_Silent_p.H460H|AOAH_uc011kba.1_Silent_p.H428H	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	460					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						ACATCCAGCCGTGGCAGGGGC	0.512		NaN											0	0	0	0.00308	0	7	61									
CUX1	1523	broad.mit.edu	37	7	101845239	101845239	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr7:101845239C>G	uc003uyx.3	+	18	2700	c.2662C>G	c.(2662-2664)CCA>GCA	p.P888A	CUX1_uc003uys.3_Missense_Mutation_p.P899A|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	888					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CGCTGAGTCCCCATACTCCCA	0.672		NaN											0	0	0	0.016723	0	12	61									
CAV1	857	broad.mit.edu	37	7	116166725	116166725	+	Silent	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr7:116166725C>G	uc003vif.1	+	2	455	c.177C>G	c.(175-177)CTC>CTG	p.L59L	CAV1_uc010lkd.1_Silent_p.L28L|CAV1_uc010lke.1_Silent_p.L28L|CAV1_uc003vig.1_RNA|CAV1_uc003vih.2_Silent_p.L28L|CAV1_uc010lkf.1_Silent_p.L28L	NM_001753	NP_001744	Q03135	CAV1_HUMAN	caveolin 1	59	Cytoplasmic (Potential).				blood coagulation|calcium ion transport|caveola assembly|cellular response to starvation|cholesterol homeostasis|cytosolic calcium ion homeostasis|inactivation of MAPK activity|interspecies interaction between organisms|leukocyte migration|lipid storage|maintenance of protein location in cell|mammary gland involution|membrane depolarization|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of endothelial cell proliferation|negative regulation of epithelial cell differentiation|negative regulation of nitric oxide biosynthetic process|negative regulation of peptidyl-serine phosphorylation|negative regulation of protein binding|negative regulation of transcription from RNA polymerase II promoter|nitric oxide homeostasis|nitric oxide metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of metalloenzyme activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of vasoconstriction|protein homooligomerization|receptor internalization|regulation of blood coagulation|regulation of fatty acid metabolic process|regulation of nitric-oxide synthase activity|regulation of smooth muscle contraction|response to calcium ion|response to estrogen stimulus|response to hypoxia|response to progesterone stimulus|skeletal muscle tissue development|T cell costimulation|triglyceride metabolic process|vasculogenesis|vesicle organization	apical plasma membrane|basolateral plasma membrane|caveola|caveola|cytosol|endoplasmic reticulum|endosome|Golgi membrane|lipid particle|perinuclear region of cytoplasm	cholesterol binding|nitric-oxide synthase binding|peptidase activator activity|protein binding|protein complex scaffold|receptor binding				0	all_epithelial(6;1.42e-06)|Lung NSC(10;0.0056)|all_lung(10;0.00609)		STAD - Stomach adenocarcinoma(10;0.00878)			CTAAACACCTCAACGATGACG	0.577		NaN									OREG0018273	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	45									
FNTA	2339	broad.mit.edu	37	8	42939973	42939973	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr8:42939973G>A	uc003xps.2	+	8	1014	c.966G>A	c.(964-966)ATG>ATA	p.M322I	FNTA_uc003xpt.2_Missense_Mutation_p.M231I|FNTA_uc003xpu.2_Missense_Mutation_p.M255I|FNTA_uc003xpv.2_RNA	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	322					cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			ATGAAGACATGCTAGAAAATC	0.358		NaN											0	0	0	0.021553	0	4	71									
MMP16	4325	broad.mit.edu	37	8	89198769	89198769	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr8:89198769G>A	uc003yeb.3	-	3	622	c.340C>T	c.(340-342)CAT>TAT	p.H114Y	MMP16_uc003yec.2_Missense_Mutation_p.H114Y	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	114					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						CGACGAATATGAAATTTGGAG	0.413		NaN											0	0	0	0.006214	0	9	154									
PKHD1L1	93035	broad.mit.edu	37	8	110457514	110457514	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr8:110457514C>T	uc003yne.2	+	38	5520	c.5416C>T	c.(5416-5418)CCA>TCA	p.P1806S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1806	Extracellular (Potential).|IPT/TIG 10.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GACTCCTCTCCCAGTTGGACA	0.468		NaN								HNSCC(38;0.096)			0	0	0	0.02938	0	7	67									
DOCK8	81704	broad.mit.edu	37	9	434792	434792	+	Silent	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr9:434792G>A	uc003zgf.2	+	39	5008	c.4896G>A	c.(4894-4896)AAG>AAA	p.K1632K	DOCK8_uc010mgu.2_Silent_p.K934K|DOCK8_uc010mgv.2_Silent_p.K1532K|DOCK8_uc003zgk.2_Silent_p.K1090K	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1632	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GAATTGCCAAGAGTTACCAGG	0.478		NaN											0	0	0	0.014758	0	5	41									
RUSC2	9853	broad.mit.edu	37	9	35547473	35547473	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr9:35547473G>A	uc003zww.2	+	2	1210	c.955G>A	c.(955-957)GCC>ACC	p.A319T	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.A319T	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	319						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			AGACCCTGGCGCCTTCTATCT	0.567		NaN											0	0	0	0.00308	0	7	61									
FAM75A6	389730	broad.mit.edu	37	9	43625185	43625185	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr9:43625185G>A	uc011lrb.1	-	4	3531	c.3502C>T	c.(3502-3504)CAG>TAG	p.Q1168*		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1168						integral to membrane					0						AAAATCCACTGAAAAAATTGC	0.428		NaN											0	0	0	0.013537	0	9	186									
C9orf3	84909	broad.mit.edu	37	9	97767884	97767884	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr9:97767884G>C	uc004ava.2	+	12	2236	c.2101G>C	c.(2101-2103)GAG>CAG	p.E701Q	C9orf3_uc004auy.2_Missense_Mutation_p.E602Q|C9orf3_uc004auz.1_Missense_Mutation_p.E602Q|C9orf3_uc004avc.2_Missense_Mutation_p.E156Q|C9orf3_uc011luj.1_Missense_Mutation_p.E63Q|C9orf3_uc011luk.1_Missense_Mutation_p.E42Q|C9orf3_uc004avd.2_Missense_Mutation_p.E63Q|C9orf3_uc004ave.1_RNA	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	701					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		GGAGAAGGAAGAGGTGTTTGA	0.522		NaN											0	0	0	0.00308	0	8	59									
TDRD7	23424	broad.mit.edu	37	9	100249560	100249560	+	Silent	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr9:100249560C>T	uc004axj.2	+	16	3247	c.3022C>T	c.(3022-3024)CTA>TTA	p.L1008L	TDRD7_uc011lux.1_Silent_p.L934L|TDRD7_uc011luy.1_Silent_p.L328L	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	1008	Interacts with CDK17 (By similarity).|Interacts with CABLES1 (By similarity).				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)				AGTACAGCCCCTAGTGGACAT	0.433		NaN											0	0	0	0.00308	0	8	78									
EGFL7	51162	broad.mit.edu	37	9	139563050	139563050	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr9:139563050C>G	uc004cid.2	+	4	1033	c.122C>G	c.(121-123)TCC>TGC	p.S41C	EGFL7_uc004cif.2_Missense_Mutation_p.S41C|EGFL7_uc004cig.2_RNA|EGFL7_uc010nbp.2_Missense_Mutation_p.S41C|EGFL7_uc004cie.2_Missense_Mutation_p.S41C|EGFL7_uc004cih.2_Missense_Mutation_p.S41C|MIR126_hsa-mir-126|MI0000471_5'Flank	NM_201446	NP_958854	Q9UHF1	EGFL7_HUMAN	EGF-like-domain, multiple 7	41	EMI.				angiogenesis|vasculogenesis		calcium ion binding			ovary(1)	1	all_cancers(76;0.109)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		GACCCTGTCTCCGAGTCGTTC	0.677		NaN											0	0	0	0.008291	0	11	97									
IL1RAPL2	26280	broad.mit.edu	37	X	104478538	104478538	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chrX:104478538G>C	uc004elz.1	+	4	1149	c.393G>C	c.(391-393)TTG>TTC	p.L131F		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	131	Ig-like C2-type 1.|Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						CAATGTCCTTGACTGTTGCAG	0.393		NaN											0	0	0	0.006214	0	9	71									
RIPPLY1	92129	broad.mit.edu	37	X	106144121	106144121	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chrX:106144121G>A	uc004emr.1	-	4	358	c.314C>T	c.(313-315)TCC>TTC	p.S105F	MORC4_uc004emp.3_Intron|CLDN2_uc004emq.1_Intron|RIPPLY1_uc004ems.1_Missense_Mutation_p.S58F	NM_138382	NP_612391	Q0D2K3	RIPP1_HUMAN	ripply1 homolog	105	Ripply homology domain.				negative regulation of transcription, DNA-dependent|somite rostral/caudal axis specification|somite specification|transcription, DNA-dependent	nucleus					0						GAAGGAGCGGGATTTAGGCCA	0.512		NaN											0	0	0	0.014758	0	5	6									
CLDN2	9075	broad.mit.edu	37	X	106171926	106171926	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chrX:106171926G>A	uc004emq.1	+	2	987	c.468G>A	c.(466-468)ATG>ATA	p.M156I	MORC4_uc004emp.3_Intron|CLDN2_uc004emt.1_Missense_Mutation_p.M156I	NM_020384	NP_065117	P57739	CLD2_HUMAN	claudin 2	156	Extracellular (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1						CTGACAGCATGAAATTTGAGA	0.478		NaN											0	0	0	0.016723	0	14	63									
CUL4B	8450	broad.mit.edu	37	X	119694330	119694330	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chrX:119694330C>T	uc004esw.2	-	3	655	c.218G>A	c.(217-219)AGA>AAA	p.R73K	CUL4B_uc004esv.2_Missense_Mutation_p.R55K	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	73	Ser-rich.				cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						AAAGTCTTCTCTCTCGTTAct	0.438		NaN											0	0	0	0.014758	0	5	15									
ODZ1	10178	broad.mit.edu	37	X	123805551	123805551	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chrX:123805551C>T	uc004euj.2	-	6	1214	c.1150G>A	c.(1150-1152)GAT>AAT	p.D384N	ODZ1_uc011muj.1_Missense_Mutation_p.D383N|ODZ1_uc010nqy.2_Missense_Mutation_p.D384N	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	384	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TCTGATTTATCAGAAACTTTT	0.398		NaN											0	0	0	0.004482	0	9	55									
ARHGAP36	158763	broad.mit.edu	37	X	130219951	130219951	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chrX:130219951A>T	uc004evz.2	+	9	1514	c.1169A>T	c.(1168-1170)AAA>ATA	p.K390I	ARHGAP36_uc004ewa.2_Missense_Mutation_p.K378I|ARHGAP36_uc004ewb.2_Missense_Mutation_p.K359I|ARHGAP36_uc004ewc.2_Missense_Mutation_p.K254I	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	390	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						CTCCTGAAAAAAGGAAAGTTT	0.468		NaN											0	0	0	0.02938	0	7	120									
HCFC1	3054	broad.mit.edu	37	X	153225574	153225574	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chrX:153225574C>T	uc004fjp.2	-	8	1651	c.1123G>A	c.(1123-1125)GCC>ACC	p.A375T		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	375					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTGGTGTTGGCGCGTACCAGT	0.617		NaN											0	0	0	0.004672	0	3	11									
ABCA10	10349	broad.mit.edu	37	17	67183864	67183864	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:67183864delC	uc010dfa.1	-	20	3167	c.2288delG	c.(2287-2289)CGCfs	p.R763fs	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Frame_Shift_Del_p.R364fs	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	763					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					CTTTAAGAAGCGAAGTGTTGC	0.378		NaN											NaN	NaN	NaN	NaN	NaN	7	118	---	---							
CAPN13	92291	broad.mit.edu	37	2	30974059	30974059	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:30974059delG	uc002rnn.2	-	11	1322	c.1146delC	c.(1144-1146)ACCfs	p.T382fs	CAPN13_uc002rnp.1_Frame_Shift_Del_p.T382fs	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	382					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					CGACAACATTGGTGCCTTCCA	0.468		NaN											NaN	NaN	NaN	NaN	NaN	8	46	---	---							
NFAM1	150372	broad.mit.edu	37	22	42828309	42828310	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:42828309_42828310insT	uc003bcn.3	-	1	92_93	c.54_55insA	c.(52-57)CCTGGGfs	p.P18fs		NM_145912	NP_666017	Q8NET5	NFAM1_HUMAN	NFAT activation molecule 1 precursor	18_19					B cell differentiation|inflammatory response|intracellular signal transduction|positive regulation of B cell receptor signaling pathway|positive regulation of cytokine production|positive regulation of sequence-specific DNA binding transcription factor activity	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity				0						GCGGGGAGCCCAGGAGGGCGTG	0.663		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
