Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
C1orf158	93190	broad.mit.edu	37	1	12819342	12819342	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr1:12819342C>T	uc001auh.2	+	3	541	c.325C>T	c.(325-327)CCG>TCG	p.P109S	C1orf158_uc010obe.1_Missense_Mutation_p.P109S	NM_152290	NP_689503	Q8N1D5	CA158_HUMAN	hypothetical protein LOC93190	109										ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTTACAACCCGGGGCTGCC	0.537		NaN											0	0	0	0.006122	0	17	182									
PTPRU	10076	broad.mit.edu	37	1	29651735	29651735	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr1:29651735C>T	uc001bru.2	+	30	4285	c.4175C>T	c.(4174-4176)GCC>GTC	p.A1392V	PTPRU_uc001brv.2_Missense_Mutation_p.A1388V|PTPRU_uc001brw.2_Missense_Mutation_p.A1382V|PTPRU_uc009vtq.2_Missense_Mutation_p.A1386V|PTPRU_uc009vtr.2_Missense_Mutation_p.A1379V|PTPRU_uc001brx.2_Missense_Mutation_p.A118V	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1392	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		ACCTTCTGCGCCTGCGCCACG	0.577		NaN											0	0	0	0.010729	0	9	89									
IL23R	149233	broad.mit.edu	37	1	67666418	67666418	+	Splice_Site	SNP	A	A	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr1:67666418A>C	uc001ddo.2	+	5	577	c.492_splice	c.e5-2	p.S164_splice	IL23R_uc009waz.2_Intron|IL23R_uc001ddp.2_Splice_Site|IL23R_uc010opi.1_Splice_Site|IL23R_uc010opj.1_Intron|IL23R_uc010opk.1_Splice_Site_p.S121_splice|IL23R_uc010opl.1_Intron|IL23R_uc010opm.1_Splice_Site|IL23R_uc001ddq.2_Intron|IL23R_uc010opn.1_Splice_Site_p.I9_splice|IL23R_uc001ddr.2_Splice_Site|IL23R_uc010opo.1_Splice_Site_p.S23_splice|IL23R_uc010opp.1_Splice_Site|IL23R_uc010opq.1_Splice_Site_p.S23_splice|IL23R_uc010opr.1_Splice_Site|IL23R_uc010ops.1_Intron|IL23R_uc010opt.1_Splice_Site|IL23R_uc010opu.1_Intron|IL23R_uc010opv.1_Splice_Site_p.S23_splice|IL23R_uc010opw.1_Intron|IL23R_uc010opx.1_Intron|IL23R_uc010opy.1_Intron|IL23R_uc010opz.1_Intron|IL23R_uc010oqa.1_Splice_Site|IL23R_uc010oqb.1_Splice_Site_p.S23_splice|IL23R_uc010oqc.1_Intron|IL23R_uc010oqd.1_Intron|IL23R_uc010oqe.1_Intron|IL23R_uc010oqf.1_Intron|IL23R_uc010oqg.1_Splice_Site|IL23R_uc010oqh.1_Intron	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor precursor						inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0						TTTTGTTTTAAGTTTAGAGAC	0.239		NaN											0	0	0	0.001168	0	5	75									
NRAS	4893	broad.mit.edu	37	1	115258745	115258745	+	Missense_Mutation	SNP	C	C	G	rs121434595		TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr1:115258745C>G	uc009wgu.2	-	2	291	c.37G>C	c.(37-39)GGT>CGT	p.G13R		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	13	GTP.		G -> D (in a patient with an autoimmune lymphoproliferative disorder).|G -> R (in colorectal cancer).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.G13D(174)|p.G13R(59)|p.G13V(55)|p.G13C(21)|p.G13A(16)|p.G13S(5)|p.G13G(3)|p.G13N(1)|p.G13Y(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCCCAACACCACCTGCTCCA	0.498	G13R(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			0	0	0	0.006214	0	9	97									
RUSC1	23623	broad.mit.edu	37	1	155294949	155294949	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr1:155294949G>A	uc001fkj.2	+	4	1742	c.1513G>A	c.(1513-1515)GCC>ACC	p.A505T	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fki.2_5'Flank|RUSC1_uc001fkk.2_Missense_Mutation_p.A505T|RUSC1_uc009wqn.1_Intron|RUSC1_uc009wqo.1_Missense_Mutation_p.A36T|RUSC1_uc001fkl.2_Missense_Mutation_p.A95T|RUSC1_uc001fkp.2_Missense_Mutation_p.A36T|RUSC1_uc001fkq.2_Missense_Mutation_p.A36T|RUSC1_uc010pgb.1_Missense_Mutation_p.A36T|RUSC1_uc009wqp.1_5'UTR|RUSC1_uc001fkn.2_5'UTR|RUSC1_uc001fko.2_RNA|RUSC1_uc001fkr.2_Missense_Mutation_p.A36T|RUSC1_uc001fks.2_5'Flank	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	505						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			TTTCGGGGCCGCCCGGAACTT	0.622		NaN									OREG0013860	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014323	0	19	146									
MPZ	4359	broad.mit.edu	37	1	161276712	161276712	+	Splice_Site	SNP	C	C	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr1:161276712C>A	uc001gaf.3	-	3	302	c.265_splice	c.e3-1	p.I89_splice	MPZ_uc010pko.1_Splice_Site	NM_000530	NP_000521	P25189	MYP0_HUMAN	myelin protein zero						synaptic transmission	integral to plasma membrane	structural molecule activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)	Breast(1374;0.181)	BRCA - Breast invasive adenocarcinoma(70;0.00376)			AGTGGAAGATCTATGAGGAAT	0.463		NaN											1	0	1.836e-18	0.003755	2.13644e-18	37	68									
EPRS	2058	broad.mit.edu	37	1	220195731	220195731	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr1:220195731C>T	uc001hly.1	-	9	1343	c.1073G>A	c.(1072-1074)CGC>CAC	p.R358H	EPRS_uc010puf.1_Missense_Mutation_p.R109H|EPRS_uc001hlz.1_Missense_Mutation_p.R358H|EPRS_uc009xdt.1_Missense_Mutation_p.R159H	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	358	Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	AATTTTGCAGCGATAAAGGGT	0.383		NaN											0	0	0	0.008291	0	11	204									
CUL2	8453	broad.mit.edu	37	10	35360158	35360158	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:35360158C>T	uc001ixv.2	-	2	298	c.88G>A	c.(88-90)GTC>ATC	p.V30I	CUL2_uc009xma.2_5'UTR|CUL2_uc010qer.1_Missense_Mutation_p.V49I|CUL2_uc001ixw.2_Missense_Mutation_p.V30I|CUL2_uc010qes.1_Missense_Mutation_p.V30I	NM_003591	NP_003582	Q13617	CUL2_HUMAN	cullin 2	30					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			ovary(3)	3						GCTCTTTCGACGTATTCCAAC	0.358		NaN											0	0	0	0.001855	0	12	70									
HK1	3098	broad.mit.edu	37	10	71149006	71149006	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:71149006G>A	uc001jpl.3	+	14	2090	c.1989G>A	c.(1987-1989)ATG>ATA	p.M663I	HK1_uc001jpg.3_Missense_Mutation_p.M651I|HK1_uc001jph.3_Missense_Mutation_p.M667I|HK1_uc001jpi.3_Missense_Mutation_p.M667I|HK1_uc001jpj.3_Missense_Mutation_p.M698I|HK1_uc001jpk.3_Missense_Mutation_p.M662I|HK1_uc009xqd.2_Missense_Mutation_p.M541I	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	663	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						GCACCATGATGACCTGTGCTT	0.527		NaN											0	0	0	0.004672	0	3	15									
KIAA1274	27143	broad.mit.edu	37	10	72292376	72292376	+	Splice_Site	SNP	G	G	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:72292376G>T	uc001jrd.3	+	6	915	c.634_splice	c.e6-1	p.I212_splice		NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274											ovary(2)|central_nervous_system(1)	3						CCTCCCTCTAGATCCACGACT	0.597		NaN											1	0	0.00909568	0.009096	0.00938909	4	70									
C10orf54	64115	broad.mit.edu	37	10	73521607	73521607	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:73521607G>A	uc001jsd.2	-	2	400	c.259C>T	c.(259-261)CGG>TGG	p.R87W	CDH23_uc001jrx.3_Intron|C10orf54_uc001jse.2_5'UTR|C10orf54_uc009xqm.2_Intron|C10orf54_uc001jsf.1_Missense_Mutation_p.R87W	NM_022153	NP_071436	Q9H7M9	GI24_HUMAN	platelet receptor Gi24 precursor	87	Ig-like.|Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)|central_nervous_system(1)	3						CGGATGGGCCGGCGCTCTGAG	0.652		NaN											0	0	0	0.004672	0	3	43									
ECD	11319	broad.mit.edu	37	10	74896575	74896575	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:74896575C>T	uc001jtn.2	-	13	1834	c.1591G>A	c.(1591-1593)GAA>AAA	p.E531K	ECD_uc009xqx.2_Missense_Mutation_p.E564K|ECD_uc009xqy.2_Missense_Mutation_p.E488K|ECD_uc001jto.2_Missense_Mutation_p.E230K	NM_007265	NP_009196	O95905	SGT1_HUMAN	suppressor of S. cerevisiae gcr2 isoform 1	531					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			pancreas(1)	1	Prostate(51;0.0119)					GAAGCCTCTTCGCCAGGTTCG	0.448		NaN											0	0	0	0.006214	0	9	165									
SORCS1	114815	broad.mit.edu	37	10	108459108	108459108	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:108459108G>A	uc001kym.2	-	9	1285	c.1277C>T	c.(1276-1278)GCG>GTG	p.A426V	SORCS1_uc001kyl.2_Missense_Mutation_p.A426V|SORCS1_uc009xxs.2_Missense_Mutation_p.A426V|SORCS1_uc001kyn.1_Missense_Mutation_p.A426V|SORCS1_uc001kyo.2_Missense_Mutation_p.A426V	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	426	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TTCTTGGACCGCTGCGAACAC	0.478		NaN											0	0	0	0.001168	0	5	34									
TRUB1	142940	broad.mit.edu	37	10	116731913	116731913	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:116731913G>C	uc001lcd.2	+	6	677	c.616G>C	c.(616-618)GAT>CAT	p.D206H	TRUB1_uc010qsl.1_Missense_Mutation_p.D108H	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	206					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		ATTAAAGAAAGATGGACAAAG	0.413		NaN											0	0	0	0.014323	0	21	34									
SEC23IP	11196	broad.mit.edu	37	10	121677504	121677504	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:121677504G>C	uc001leu.1	+	9	1773	c.1701G>C	c.(1699-1701)ATG>ATC	p.M567I	SEC23IP_uc010qtc.1_Missense_Mutation_p.M356I|SEC23IP_uc009xzk.1_5'Flank	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	567					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		CACTCTTTATGAGTCGGAACC	0.363		NaN											0	0	0	0.010729	0	10	82									
DCHS1	8642	broad.mit.edu	37	11	6661191	6661191	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:6661191C>T	uc001mem.1	-	2	2064	c.1654G>A	c.(1654-1656)GAT>AAT	p.D552N		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	552	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGCCACCATCTGTGGCCACC	0.547		NaN											0	0	0	0.013537	0	13	82									
PPFIBP2	8495	broad.mit.edu	37	11	7642183	7642183	+	Silent	SNP	C	C	T	rs150433585		TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:7642183C>T	uc001mfj.3	+	7	1024	c.636C>T	c.(634-636)CTC>CTT	p.L212L	PPFIBP2_uc010rbb.1_Silent_p.L135L|PPFIBP2_uc001mfk.1_Intron|PPFIBP2_uc010rbc.1_Silent_p.L135L|PPFIBP2_uc010rbd.1_Silent_p.L54L|PPFIBP2_uc010rbe.1_Silent_p.L100L|PPFIBP2_uc001mfl.3_Silent_p.L69L	NM_003621	NP_003612	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2	212	Potential.				cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			ovary(2)|breast(2)	4				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		TGCAAGAGCTCAGGCACCTCA	0.423		NaN											0	0	0	0.00874	0	36	29									
CDCA5	113130	broad.mit.edu	37	11	64846850	64846850	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:64846850T>A	uc001ocp.2	-	5	818	c.653A>T	c.(652-654)AAG>ATG	p.K218M		NM_080668	NP_542399	Q96FF9	CDCA5_HUMAN	cell division cycle associated 5	218					cell division|double-strand break repair|G1/S transition of mitotic cell cycle|mitotic chromosome condensation|mitotic metaphase plate congression|mitotic sister chromatid cohesion|regulation of cohesin localization to chromatin	cytoplasm|nuclear chromatin|plasma membrane	chromatin binding|identical protein binding				0						TTTCTTCTTCTTACGTTTCTG	0.567		NaN											0	0	0	0.000602	0	4	50									
PRCP	5547	broad.mit.edu	37	11	82549509	82549509	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:82549509C>G	uc001ozs.2	-	8	1307	c.1194G>C	c.(1192-1194)TGG>TGC	p.W398C	PRCP_uc001ozr.2_Missense_Mutation_p.W419C	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	398					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						GTCTCACACCCCACTGTTGAA	0.418		NaN											0	0	0	0.010729	0	11	31									
CASP4	837	broad.mit.edu	37	11	104825572	104825573	+	Missense_Mutation	DNP	CG	CG	AA			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:104825572_104825573CG>AA	uc001pid.1	-	2	236_237	c.163_164CG>TT	c.(163-165)CGG>TTG	p.R55L	CASP4_uc001pib.1_5'UTR|CASP4_uc009yxg.1_5'UTR|CASP4_uc010rux.1_Missense_Mutation_p.R55L|CASP4_uc010ruy.1_Missense_Mutation_p.R55L	NM_001225	NP_001216	P49662	CASP4_HUMAN	caspase 4 isoform alpha precursor	55	CARD.				apoptosis|induction of apoptosis|proteolysis	intracellular	cysteine-type endopeptidase activity|protein binding			lung(2)|ovary(1)|skin(1)	4		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000854)|Epithelial(105;0.00879)|all cancers(92;0.0357)		TGCCATGACCCGAACTTTGTCT	0.386		NaN											0	0	0	0.004672	0	9	87									
C11orf87	399947	broad.mit.edu	37	11	109294575	109294575	+	Silent	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:109294575C>T	uc001pkn.2	+	2	590	c.216C>T	c.(214-216)TTC>TTT	p.F72F	C11orf87_uc010rwb.1_5'Flank	NM_207645	NP_997528	Q6NUJ2	CK087_HUMAN	hypothetical protein LOC399947 precursor	72	Helical; (Potential).					integral to membrane				ovary(2)	2						CCCTCATCTTCTGCCTCATCG	0.572		NaN											0	0	0	0.00308	0	8	71									
OR6T1	219874	broad.mit.edu	37	11	123813872	123813872	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:123813872A>G	uc010sab.1	-	1	674	c.674T>C	c.(673-675)GTT>GCT	p.V225A		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GGCCCTGAGAACAGTGGCAAG	0.527		NaN											0	0	0	0.001168	0	6	47									
OPCML	4978	broad.mit.edu	37	11	132306671	132306671	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:132306671G>A	uc001qgs.2	-	5	717	c.667C>T	c.(667-669)CCT>TCT	p.P223S	OPCML_uc001qgu.2_Missense_Mutation_p.P216S|OPCML_uc010sck.1_Missense_Mutation_p.P223S|OPCML_uc001qgt.2_Missense_Mutation_p.P222S|OPCML_uc010scl.1_Missense_Mutation_p.P182S	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	223	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		ATATAGGGAGGATCTGTGGGA	0.393		NaN											0	0	0	0.004672	0	3	20									
KCNA1	3736	broad.mit.edu	37	12	5020706	5020706	+	Silent	SNP	C	C	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr12:5020706C>A	uc001qnh.2	+	2	1267	c.162C>A	c.(160-162)ACC>ACA	p.T54T		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	54					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AGCTCAAGACCCTGGCGCAGT	0.637		NaN											1	0	2.21704e-12	0.00278	2.55658e-12	23	50									
ABCC9	10060	broad.mit.edu	37	12	22015990	22015990	+	Splice_Site	SNP	T	T	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr12:22015990T>A	uc001rfi.1	-	18	2258	c.2238_splice	c.e18-1	p.S746_splice	ABCC9_uc001rfh.2_Splice_Site_p.S746_splice|ABCC9_uc001rfj.1_Splice_Site_p.S710_splice	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9						defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTGTTCCTACTGAAAAATGAA	0.318		NaN											0	0	0	0.009096	0	4	44									
RNFT2	84900	broad.mit.edu	37	12	117274059	117274059	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr12:117274059T>C	uc009zwn.2	+	10	1405	c.1172T>C	c.(1171-1173)TTC>TCC	p.F391S	RNFT2_uc001twb.3_Missense_Mutation_p.F391S|RNFT2_uc001twa.3_Missense_Mutation_p.F301S|RNFT2_uc001twc.3_Missense_Mutation_p.F139S	NM_001109903	NP_001103373	Q96EX2	RNFT2_HUMAN	transmembrane protein 118 isoform 1	391	Extracellular (Potential).|RING-type.					integral to membrane	zinc ion binding				0	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.034)		CAGGCCGAGTTCCGAGAGCCT	0.602		NaN											0	0	0	0.004672	0	3	6									
NCOR2	9612	broad.mit.edu	37	12	124816920	124816920	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr12:124816920C>G	uc010tay.1	-	45	7035	c.6879G>C	c.(6877-6879)AAG>AAC	p.K2293N	NCOR2_uc010taz.1_Missense_Mutation_p.K2277N|NCOR2_uc010tax.1_Missense_Mutation_p.K404N	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	2294					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TCTCTTGCTTCTTGGACTTGA	0.587		NaN									OREG0022237	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	9	111									
SACS	26278	broad.mit.edu	37	13	23906256	23906256	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr13:23906256C>G	uc001uon.2	-	10	12348	c.11759G>C	c.(11758-11760)AGC>ACC	p.S3920T	SACS_uc001uoo.2_Missense_Mutation_p.S3773T|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3920					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CACTAAGATGCTTGACTTTAC	0.438		NaN											0	0	0	0.004482	0	9	147									
SOHLH2	54937	broad.mit.edu	37	13	36744906	36744906	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr13:36744906G>C	uc001uvj.2	-	10	1108	c.1019C>G	c.(1018-1020)TCA>TGA	p.S340*	SOHLH2_uc010tei.1_Nonsense_Mutation_p.S417*	NM_017826	NP_060296	Q9NX45	SOLH2_HUMAN	spermatogenesis and oogenesis specific basic	340					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		AGCATTCTCTGAGGCGGAGCT	0.398		NaN											0	0	0	0.001168	0	5	95									
NEK5	341676	broad.mit.edu	37	13	52661488	52661488	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr13:52661488C>T	uc001vge.2	-	15	1518	c.1378G>A	c.(1378-1380)GAA>AAA	p.E460K		NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	460							ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		TCCTTCATTTCGTTTTTCCTA	0.393		NaN											0	0	0	0.00278	0	21	74									
TBC1D4	9882	broad.mit.edu	37	13	75936294	75936294	+	Silent	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr13:75936294G>A	uc001vjl.1	-	2	1295	c.948C>T	c.(946-948)TGC>TGT	p.C316C	TBC1D4_uc010aer.2_Silent_p.C316C|TBC1D4_uc010aes.2_Silent_p.C316C	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	316	PID 2.					cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		TGACACTGCTGCACCGAGACC	0.637		NaN											0	0	0	0.001168	0	5	46									
OR6S1	341799	broad.mit.edu	37	14	21109226	21109226	+	Missense_Mutation	SNP	C	C	G	rs150042729		TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr14:21109226C>G	uc001vxv.1	-	1	625	c.625G>C	c.(625-627)GTC>CTC	p.V209L		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		GATACAATGACGAGGGAGGCC	0.572		NaN											0	0	0	0.000602	0	5	98									
EAPP	55837	broad.mit.edu	37	14	34985629	34985629	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr14:34985629C>G	uc001wsd.1	-	6	854	c.745G>C	c.(745-747)GAT>CAT	p.D249H		NM_018453	NP_060923	Q56P03	EAPP_HUMAN	E2F-associated phosphoprotein	249					negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of transcription elongation from RNA polymerase II promoter	Golgi apparatus|nucleus|plasma membrane				ovary(1)	1	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00342)|Epithelial(34;0.18)	GBM - Glioblastoma multiforme(112;0.0196)		TCTTCCACATCTGTCTCTGCC	0.448		NaN											0	0	0	0.008291	0	9	195									
EAPP	55837	broad.mit.edu	37	14	34985718	34985718	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr14:34985718C>G	uc001wsd.1	-	6	765	c.656G>C	c.(655-657)AGA>ACA	p.R219T		NM_018453	NP_060923	Q56P03	EAPP_HUMAN	E2F-associated phosphoprotein	219					negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of transcription elongation from RNA polymerase II promoter	Golgi apparatus|nucleus|plasma membrane				ovary(1)	1	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00342)|Epithelial(34;0.18)	GBM - Glioblastoma multiforme(112;0.0196)		GGCTTTATATCTTAGAACCTC	0.388		NaN											0	0	0	0.004482	0	9	143									
PYGO1	26108	broad.mit.edu	37	15	55841124	55841124	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr15:55841124C>T	uc010bfl.1	-	2	175	c.119G>A	c.(118-120)CGC>CAC	p.R40H	PYGO1_uc002adf.1_Missense_Mutation_p.R40H	NM_015617	NP_056432	Q9Y3Y4	PYGO1_HUMAN	pygopus homolog 1	40	Nuclear localization signal (Potential).				Wnt receptor signaling pathway	nucleus	zinc ion binding	p.R40C(1)		ovary(1)|skin(1)	2				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		ATTTGCCTTGCGCTTTTTCTT	0.368		NaN											0	0	0	0.001168	0	4	51									
GOLGA6A	342096	broad.mit.edu	37	15	74365122	74365122	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr15:74365122G>T	uc002axa.1	-	13	1503	c.1462C>A	c.(1462-1464)CTA>ATA	p.L488I		NM_001038640	NP_001033729	Q9NYA3	GOG6A_HUMAN	golgi autoantigen, golgin subfamily a, 6	488	Potential.										0						TGGGTCTCTAGCTGTTGGTTC	0.612		NaN											1	0	7.48243e-07	0.006214	8.40132e-07	7	55									
ST8SIA2	8128	broad.mit.edu	37	15	92977602	92977602	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr15:92977602T>A	uc002bra.2	+	3	442	c.287T>A	c.(286-288)ATC>AAC	p.I96N	ST8SIA2_uc002brb.2_Missense_Mutation_p.I75N	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide	96	Lumenal (Potential).				axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity				0	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			TCTCTGAGGATCAGGTACTGG	0.453		NaN											0	0	0	0.008871	0	18	55									
ZNF598	90850	broad.mit.edu	37	16	2052220	2052220	+	Silent	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr16:2052220C>T	uc002cof.1	-	7	897	c.882G>A	c.(880-882)TCG>TCA	p.S294S	ZNF598_uc002coe.1_5'UTR	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	294						intracellular	zinc ion binding			lung(1)|breast(1)	2						CGTTCCGGCGCGAGTGCCGTG	0.692		NaN											0	0	0	0.009096	0	4	15									
KIAA0556	23247	broad.mit.edu	37	16	27761348	27761348	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr16:27761348G>C	uc002dow.2	+	16	3091	c.3067G>C	c.(3067-3069)GCC>CCC	p.A1023P		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	1023										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						TATTTTACCAGCCTATGGGAA	0.532		NaN											0	0	0	0.009096	0	4	43									
SPNS1	83985	broad.mit.edu	37	16	28993242	28993242	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr16:28993242C>T	uc010vdi.1	+	8	970	c.830C>T	c.(829-831)TCC>TTC	p.S277F	uc010vct.1_Intron|SPNS1_uc002drx.2_Missense_Mutation_p.S204F|SPNS1_uc002dsa.2_Missense_Mutation_p.S277F|SPNS1_uc002drz.2_Intron|SPNS1_uc010byp.2_Intron|SPNS1_uc010byq.1_Missense_Mutation_p.S209F|LAT_uc010vdj.1_5'Flank	NM_001142448	NP_001135920	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 isoform 1	277					lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding				0						GTCCTGTCTTCCCTGGGCTTC	0.632		NaN									OREG0023712	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	5	77									
CDH11	1009	broad.mit.edu	37	16	65016031	65016031	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr16:65016031T>G	uc002eoi.2	-	8	1607	c.1173A>C	c.(1171-1173)GAA>GAC	p.E391D	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Missense_Mutation_p.E391D|CDH11_uc010vin.1_Missense_Mutation_p.E265D|CDH11_uc002eok.1_RNA	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	391	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TTTCTTGGACTTCGTGGATGT	0.498		NaN	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			0	0	0	0.001984	0	6	90									
DHX33	56919	broad.mit.edu	37	17	5365692	5365692	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr17:5365692C>G	uc002gca.2	-	3	627	c.625G>C	c.(625-627)GTG>CTG	p.V209L	DHX33_uc002gbz.2_5'Flank|DHX33_uc002gcb.2_Missense_Mutation_p.V36L|DHX33_uc010clf.2_Intron	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	209	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						GCTTTCACCACTCCAAAGAGC	0.463		NaN											0	0	0	0.009096	0	4	56									
NEURL4	84461	broad.mit.edu	37	17	7226379	7226379	+	Silent	SNP	C	C	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr17:7226379C>A	uc002gga.1	-	15	2488	c.2481G>T	c.(2479-2481)GCG>GCT	p.A827A	NEURL4_uc002ggb.1_Silent_p.A827A|NEURL4_uc002ggc.1_Silent_p.A173A	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	827	NHR 4.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						CTGTGCCCAGCGCATCCAGGT	0.602		NaN											1	0	8.12818e-05	0.001984	8.81701e-05	7	39									
ATP6V0A1	535	broad.mit.edu	37	17	40642597	40642597	+	Nonsense_Mutation	SNP	T	T	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr17:40642597T>G	uc002hzr.2	+	11	1283	c.1116T>G	c.(1114-1116)TAT>TAG	p.Y372*	ATP6V0A1_uc002hzq.2_Nonsense_Mutation_p.Y372*|ATP6V0A1_uc002hzs.2_Nonsense_Mutation_p.Y379*|ATP6V0A1_uc010wgj.1_Nonsense_Mutation_p.Y329*|ATP6V0A1_uc010wgk.1_Nonsense_Mutation_p.Y329*|ATP6V0A1_uc010cyg.2_Nonsense_Mutation_p.Y18*|ATP6V0A1_uc010wgl.1_Nonsense_Mutation_p.Y231*	NM_001130021	NP_001123493	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	372	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		AGTTTACCTATGGCTTTCAGA	0.373		NaN											0	0	0	0.001855	0	13	122									
ATP6V0A1	535	broad.mit.edu	37	17	40652912	40652912	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr17:40652912T>C	uc002hzr.2	+	16	2034	c.1867T>C	c.(1867-1869)TCT>CCT	p.S623P	ATP6V0A1_uc002hzq.2_Missense_Mutation_p.S623P|ATP6V0A1_uc002hzs.2_Missense_Mutation_p.S630P|ATP6V0A1_uc010wgj.1_Missense_Mutation_p.S580P|ATP6V0A1_uc010wgk.1_Missense_Mutation_p.S580P|ATP6V0A1_uc010cyg.2_Missense_Mutation_p.S269P|ATP6V0A1_uc010wgl.1_Missense_Mutation_p.S482P	NM_001130021	NP_001123493	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	623	Helical; (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		CTACCCAGAGTCTGGTTATTC	0.438		NaN											0	0	0	0.00308	0	7	134									
BRCA1	672	broad.mit.edu	37	17	41244840	41244840	+	Missense_Mutation	SNP	C	C	G	rs80357717		TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr17:41244840C>G	uc002icq.2	-	10	2940	c.2708G>C	c.(2707-2709)TGT>TCT	p.C903S	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.C832S|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.C856S|BRCA1_uc002ict.2_Missense_Mutation_p.C903S|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.C903S|BRCA1_uc002ide.1_Missense_Mutation_p.C734S|BRCA1_uc010cyy.1_Missense_Mutation_p.C903S|BRCA1_uc010whs.1_Missense_Mutation_p.C903S|BRCA1_uc010cyz.2_Missense_Mutation_p.C856S|BRCA1_uc010cza.2_Missense_Mutation_p.C877S|BRCA1_uc010wht.1_Missense_Mutation_p.C607S	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	903					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CTTTTGTTCACATTCAAAAGT	0.403		NaN	D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			0	0	0	0.010729	0	12	96									
COIL	8161	broad.mit.edu	37	17	55027860	55027860	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr17:55027860G>A	uc002iuu.2	-	2	774	c.743C>T	c.(742-744)TCG>TTG	p.S248L		NM_004645	NP_004636	P38432	COIL_HUMAN	coilin	248	2 X 4 AA repeats of A-R-N-S.|Ser/Thr-rich.					Cajal body|nucleolus	protein C-terminus binding			ovary(1)	1	Breast(9;6.15e-08)					TTCAGACTCCGAGGAGGAACT	0.428		NaN											0	0	0	0.00308	0	8	124									
THOC1	9984	broad.mit.edu	37	18	252549	252549	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr18:252549G>C	uc002kkj.3	-	9	707	c.667C>G	c.(667-669)CCA>GCA	p.P223A	THOC1_uc002kkk.3_RNA|THOC1_uc002kkl.2_Missense_Mutation_p.P223A	NM_005131	NP_005122	Q96FV9	THOC1_HUMAN	THO complex 1	223					apoptosis|intronless viral mRNA export from host nucleus|mRNA processing|regulation of transcription elongation, DNA-dependent|RNA splicing|signal transduction|transcription, DNA-dependent	cytoplasm|nuclear matrix|nuclear speck|THO complex part of transcription export complex	DNA binding|protein binding|RNA binding			ovary(1)	1		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				CACGTTGTTGGAGCTTCCTCG	0.398		NaN											0	0	0	0.003163	0	12	100									
PIK3C3	5289	broad.mit.edu	37	18	39584404	39584404	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr18:39584404C>T	uc002lap.2	+	10	1127	c.1069C>T	c.(1069-1071)CCG>TCG	p.P357S	PIK3C3_uc010xcl.1_Missense_Mutation_p.P294S	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	357					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						AAAATGGAAGCCGATGGATGT	0.463		NaN								TSP Lung(28;0.18)			0	0	0	0.009096	0	3	42									
MUC16	94025	broad.mit.edu	37	19	9085813	9085813	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr19:9085813G>C	uc002mkp.2	-	1	6206	c.6002C>G	c.(6001-6003)TCA>TGA	p.S2001*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2001	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATATGGAGTTGACTGTGTCTG	0.468		NaN											0	0	0	0.004482	0	9	70									
ZNF99	7652	broad.mit.edu	37	19	22941848	22941848	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr19:22941848T>G	uc010xrh.1	-	5	590	c.590A>C	c.(589-591)GAA>GCA	p.E197A		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GCCACATTCTTCACATTTATA	0.363		NaN											0	0	0	0.000602	0	5	50									
MAP4K1	11184	broad.mit.edu	37	19	39086328	39086328	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr19:39086328C>A	uc002oix.1	-	28	2329	c.2221G>T	c.(2221-2223)GGA>TGA	p.G741*	MAP4K1_uc002oiw.1_Nonsense_Mutation_p.G328*|MAP4K1_uc002oiy.1_Nonsense_Mutation_p.G741*	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	741	CNH.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GTGCGAAGTCCCCGGACTGGG	0.592		NaN											1	0	1.08611e-07	0.010729	1.24127e-07	11	52									
FBXO27	126433	broad.mit.edu	37	19	39516069	39516069	+	Silent	SNP	C	C	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr19:39516069C>G	uc002okh.2	-	6	916	c.834G>C	c.(832-834)GTG>GTC	p.V278V		NM_178820	NP_849142	Q8NI29	FBX27_HUMAN	F-box protein 27	278	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			ovary(1)	1	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			GACGGACTCGCACGATCACAC	0.587		NaN											0	0	0	0.001168	0	6	113									
SAMD4B	55095	broad.mit.edu	37	19	39866391	39866391	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr19:39866391G>C	uc002olb.2	+	7	1804	c.769G>C	c.(769-771)GGG>CGG	p.G257R	SAMD4B_uc002ola.2_Missense_Mutation_p.G257R	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	257							protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			AGAGGAGCTTGGGGCCCGGGC	0.647		NaN											0	0	0	0.010818	0	30	151									
PPFIA3	8541	broad.mit.edu	37	19	49641521	49641521	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr19:49641521T>G	uc002pmr.2	+	16	2245	c.1913T>G	c.(1912-1914)GTG>GGG	p.V638G	PPFIA3_uc010yai.1_Intron|PPFIA3_uc010yaj.1_Intron|PPFIA3_uc002pms.2_Missense_Mutation_p.V506G	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	638	Potential.					cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		GAGAGTCGGGTGTCCAGCTCT	0.647		NaN											0	0	0	0.00308	0	4	22									
RHOB	388	broad.mit.edu	37	2	20647511	20647511	+	Silent	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:20647511C>T	uc002rdv.2	+	1	677	c.285C>T	c.(283-285)ATC>ATT	p.I95I		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	95					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		TGGAGAACATCCCCGAGAAGT	0.617		NaN											0	0	0	0.011902	0	43	91									
NRXN1	9378	broad.mit.edu	37	2	50724504	50724504	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:50724504C>G	uc010fbq.2	-	14	4443	c.2966G>C	c.(2965-2967)GGA>GCA	p.G989A	NRXN1_uc002rxb.3_Missense_Mutation_p.G621A|NRXN1_uc002rxe.3_Missense_Mutation_p.G949A|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	138	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AAAGTCATTTCCATCCCCACT	0.353		NaN											0	0	0	0.000602	0	5	63									
TMEM131	23505	broad.mit.edu	37	2	98504542	98504542	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:98504542T>C	uc002syh.3	-	4	561	c.332A>G	c.(331-333)GAG>GGG	p.E111G	TMEM131_uc010yvg.1_RNA	NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	111						integral to membrane				ovary(4)|central_nervous_system(2)	6						CATTGGTGGCTCAAATCGTAT	0.333		NaN											0	0	0	0.004672	0	3	32									
RAPGEF4	11069	broad.mit.edu	37	2	173825863	173825863	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:173825863A>G	uc002uhv.3	+	8	792	c.605A>G	c.(604-606)AAG>AGG	p.K202R	RAPGEF4_uc002uhu.2_Missense_Mutation_p.K202R|RAPGEF4_uc002uhw.3_Missense_Mutation_p.K58R|RAPGEF4_uc010zec.1_Missense_Mutation_p.K49R|RAPGEF4_uc010zed.1_Missense_Mutation_p.K31R|RAPGEF4_uc010zee.1_Missense_Mutation_p.K49R|RAPGEF4_uc010fqo.2_Missense_Mutation_p.K31R|RAPGEF4_uc010zef.1_5'UTR|RAPGEF4_uc010zeg.1_Missense_Mutation_p.K29R|RAPGEF4_uc010fqp.1_5'UTR|RAPGEF4_uc010zeh.1_5'UTR	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	202					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			CCTTCAGAGAAGATCCTCAGA	0.413		NaN											0	0	0	0.00308	0	8	80									
FKBP7	51661	broad.mit.edu	37	2	179343067	179343067	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:179343067C>T	uc002umk.2	-	1	289	c.160G>A	c.(160-162)GAC>AAC	p.D54N	FKBP7_uc002umm.2_Missense_Mutation_p.D54N|FKBP7_uc002uml.2_RNA|FKBP7_uc010zff.1_Missense_Mutation_p.D50N|PLEKHA3_uc002umn.2_5'Flank	NM_181342	NP_851939	Q9Y680	FKBP7_HUMAN	FK506 binding protein 7 isoform a precursor	54	PPIase FKBP-type.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			TTTAGTAGGTCTCCCTTCTTG	0.473		NaN											0	0	0	0.006214	0	8	78									
TTN	7273	broad.mit.edu	37	2	179462331	179462331	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:179462331C>T	uc010zfg.1	-	243	49998	c.49774G>A	c.(49774-49776)GTC>ATC	p.V16592I	uc002umo.2_RNA|uc002ump.1_RNA|TTN_uc010zfh.1_Missense_Mutation_p.V10287I|TTN_uc010zfi.1_Missense_Mutation_p.V10220I|TTN_uc010zfj.1_Missense_Mutation_p.V10095I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17519							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAGAATAGACGCCTTGATGG	0.398		NaN											0	0	0	0.004672	0	3	39									
ITGA4	3676	broad.mit.edu	37	2	182387015	182387015	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:182387015A>G	uc002unu.2	+	18	2783	c.2020A>G	c.(2020-2022)ACT>GCT	p.T674A	ITGA4_uc010frj.1_Missense_Mutation_p.T156A|ITGA4_uc002unv.2_5'UTR	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	674	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ATATGAAACGACTCTACATGT	0.363		NaN											0	0	0	0.009096	0	4	83									
DNAJB2	3300	broad.mit.edu	37	2	220147644	220147644	+	Silent	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:220147644G>A	uc002vkx.1	+	6	675	c.438G>A	c.(436-438)GGG>GGA	p.G146G	DNAJB2_uc002vkw.1_Silent_p.G146G|DNAJB2_uc002vky.2_5'UTR|DNAJB2_uc010zlb.1_5'UTR	NM_006736	NP_006727	P25686	DNJB2_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 2	146					ER-associated protein catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|negative regulation of protein deubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding|response to unfolded protein	inclusion body	heat shock protein binding|Hsp70 protein binding|polyubiquitin binding|proteasome binding|protein binding|unfolded protein binding				0		Renal(207;0.0474)		Epithelial(149;1.97e-06)|all cancers(144;0.00028)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTTCCCTGGGCACTCCGGTA	0.562		NaN											0	0	0	0.009096	0	4	45									
HTR2B	3357	broad.mit.edu	37	2	231978470	231978470	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:231978470T>G	uc002vro.2	-	3	1031	c.526A>C	c.(526-528)ATT>CTT	p.I176L	PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron|PSMD1_uc002vrn.1_Intron|HTR2B_uc010fxv.2_Intron	NM_000867	NP_000858	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B	176	Helical; Name=4; (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	ACCACTGTAATCTTGATGAAT	0.428		NaN											0	0	0	0.004007	0	14	202									
ARL4C	10123	broad.mit.edu	37	2	235405159	235405159	+	Silent	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:235405159G>A	uc002vvn.2	-	1	535	c.72C>T	c.(70-72)GCC>GCT	p.A24A	ARL4C_uc002vvm.3_Silent_p.A24A	NM_005737	NP_005728	P56559	ARL4C_HUMAN	ADP-ribosylation factor-like 4C	24	GTP (By similarity).				endocytic recycling|small GTPase mediated signal transduction	cytoplasm|filopodium|nucleus|plasma membrane	alpha-tubulin binding|GTP binding|GTPase activity			skin(1)	1		Breast(86;0.000596)|Renal(207;0.00339)|all_lung(227;0.00354)|all_hematologic(139;0.0494)|Lung NSC(271;0.0496)|Lung SC(224;0.164)|all_neural(83;0.173)		Epithelial(121;2.6e-19)|BRCA - Breast invasive adenocarcinoma(100;0.000296)|Lung(119;0.002)|LUSC - Lung squamous cell carcinoma(224;0.0048)		TGGTCTTGCCGGCCGAGTCCA	0.597		NaN											0	0	0	0.004672	0	3	34									
BACH1	571	broad.mit.edu	37	21	30699117	30699117	+	Silent	SNP	T	T	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr21:30699117T>G	uc002ynj.2	+	3	1087	c.972T>G	c.(970-972)TCT>TCG	p.S324S	BACH1_uc002ynk.2_Silent_p.S324S|BACH1_uc002ynl.2_RNA	NM_001186	NP_001177	O14867	BACH1_HUMAN	BTB and CNC homology 1 transcription factor	324						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|liver(1)	2						ATTCTTTGTCTCTTTTACACA	0.413		NaN											0	0	0	0.008291	0	10	266									
KRTAP24-1	643803	broad.mit.edu	37	21	31655055	31655055	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr21:31655055C>T	uc002ynv.2	-	1	222	c.196G>A	c.(196-198)GGT>AGT	p.G66S		NM_001085455	NP_001078924	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	66						keratin filament	structural molecule activity				0						GGTGCTTCACCGTAGGATTCT	0.522		NaN											0	0	0	0.001168	0	6	84									
DRG1	4733	broad.mit.edu	37	22	31816285	31816285	+	Silent	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr22:31816285G>A	uc003aku.2	+	5	587	c.456G>A	c.(454-456)CTG>CTA	p.L152L		NM_004147	NP_004138	Q9Y295	DRG1_HUMAN	developmentally regulated GTP binding protein 1	152	G.				multicellular organismal development|transcription, DNA-dependent	cytoplasm|intermediate filament cytoskeleton|nucleus	GTP binding|transcription factor binding			central_nervous_system(1)	1						TGGATGTCCTGAAACCTTTGG	0.408		NaN											0	0	0	0.00308	0	8	107									
SGOL1	151648	broad.mit.edu	37	3	20225210	20225210	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:20225210C>G	uc003cbs.2	-	3	416	c.229G>C	c.(229-231)GAA>CAA	p.E77Q	SGOL1_uc003cbr.2_Missense_Mutation_p.E77Q|SGOL1_uc010hfa.2_Missense_Mutation_p.E77Q|SGOL1_uc003cbt.2_Missense_Mutation_p.E77Q|SGOL1_uc003cbu.2_Missense_Mutation_p.E77Q|SGOL1_uc003cbv.2_Missense_Mutation_p.E77Q|SGOL1_uc003cbw.2_Missense_Mutation_p.E77Q|SGOL1_uc003cbx.2_Missense_Mutation_p.E77Q|SGOL1_uc003cby.2_Missense_Mutation_p.E77Q|SGOL1_uc003cbz.2_Missense_Mutation_p.E77Q|SGOL1_uc003cca.2_Missense_Mutation_p.E77Q|SGOL1_uc003ccb.2_Missense_Mutation_p.E77Q|SGOL1_uc003ccc.2_Missense_Mutation_p.E77Q	NM_001012410	NP_001012410	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 isoform A2	77	Potential.|Necessary for interaction with PPP2CA and PPP2R1A.				attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding				0						TCTTGGGCTTCTTTCACTTTG	0.338		NaN											0	0	0	0.001855	0	14	105									
SCN11A	11280	broad.mit.edu	37	3	38945514	38945514	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:38945514G>T	uc011ays.1	-	12	1883	c.1684C>A	c.(1684-1686)CAG>AAG	p.Q562K		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	562					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CACAGCCACTGGGGGCAACAG	0.502		NaN											1	0	0.00024832	0.009096	0.000264875	4	72									
NKTR	4820	broad.mit.edu	37	3	42680096	42680096	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:42680096C>T	uc003clo.2	+	13	3047	c.2900C>T	c.(2899-2901)TCG>TTG	p.S967L	NKTR_uc003clm.1_Missense_Mutation_p.S714L|NKTR_uc003clp.2_Missense_Mutation_p.S714L|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.S857L|NKTR_uc003clr.1_Missense_Mutation_p.S714L|NKTR_uc003cls.2_Missense_Mutation_p.S667L	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	967					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		TGTTCCAATTCGGAAAACAAT	0.408		NaN											0	0	0	0.000602	0	5	70									
ROBO1	6091	broad.mit.edu	37	3	78685192	78685192	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:78685192G>C	uc003dqe.2	-	23	3312	c.3104C>G	c.(3103-3105)TCA>TGA	p.S1035*	ROBO1_uc003dqb.2_Nonsense_Mutation_p.S996*|ROBO1_uc003dqc.2_Intron|ROBO1_uc003dqd.2_Nonsense_Mutation_p.S990*|ROBO1_uc010hoh.2_Nonsense_Mutation_p.S227*|ROBO1_uc011bgl.1_Nonsense_Mutation_p.S607*	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1035	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		ATAAACAGTTGACTCAGGGAG	0.378		NaN											0	0	0	0.009096	0	4	41									
IMPG2	50939	broad.mit.edu	37	3	100948226	100948226	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:100948226C>G	uc003duq.1	-	17	3834	c.3631G>C	c.(3631-3633)GAG>CAG	p.E1211Q	IMPG2_uc011bhe.1_Missense_Mutation_p.E1074Q|IMPG2_uc010hpj.1_RNA	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	1211	Cytoplasmic (Potential).|Hyaluronan-binding motif involved in chondroitin sulfate A- and C-binding motif (By similarity).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TTTCCCACCTCTCTGGAAAGC	0.532		NaN											0	0	0	0.004482	0	7	38									
FBXO40	51725	broad.mit.edu	37	3	121341105	121341105	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:121341105G>A	uc003eeg.2	+	3	1039	c.829G>A	c.(829-831)GAC>AAC	p.D277N		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	277					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		GAAGCAGCAGGACGTTCGTAC	0.483		NaN											0	0	0	0.001984	0	6	42									
TRIM42	287015	broad.mit.edu	37	3	140397214	140397214	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:140397214G>A	uc003eto.1	+	1	334	c.143G>A	c.(142-144)CGG>CAG	p.R48Q		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	48	Cys-rich.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						AAAGATGAGCGGAACTGCCAG	0.537		NaN											0	0	0	0.008291	0	10	158									
SMC4	10051	broad.mit.edu	37	3	160146645	160146645	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:160146645G>C	uc003fdh.2	+	18	2823	c.2710G>C	c.(2710-2712)GAC>CAC	p.D904H	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.D879H|SMC4_uc003fdj.2_Missense_Mutation_p.D904H|SMC4_uc010hwd.2_Missense_Mutation_p.D904H|SMC4_uc003fdl.2_Missense_Mutation_p.D607H	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	904	Potential.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GGCCCAACAAGACAAACTTGA	0.378		NaN											0	0	0	0.001984	0	6	90									
C4orf35	85438	broad.mit.edu	37	4	71200994	71200994	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr4:71200994G>C	uc003hff.2	+	1	324	c.238G>C	c.(238-240)GAT>CAT	p.D80H		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	80						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				ATCAGAAGATGATATGGGGAC	0.373		NaN											0	0	0	0.000602	0	5	71									
MMRN1	22915	broad.mit.edu	37	4	90872768	90872768	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr4:90872768G>T	uc003hst.2	+	7	3202	c.3131G>T	c.(3130-3132)AGC>ATC	p.S1044I	MMRN1_uc010iku.2_Missense_Mutation_p.S347I|MMRN1_uc011cds.1_Missense_Mutation_p.S786I	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	1044	EGF-like.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		GAGTATTCAAGCTGTAGTCGG	0.383		NaN											1	0	3.59834e-05	0.001168	3.93664e-05	5	53									
KIAA1109	84162	broad.mit.edu	37	4	123160717	123160717	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr4:123160717C>G	uc003ieh.2	+	27	3925	c.3880C>G	c.(3880-3882)CAG>GAG	p.Q1294E	KIAA1109_uc003iei.1_Missense_Mutation_p.Q1047E|KIAA1109_uc010ins.1_Missense_Mutation_p.Q637E|KIAA1109_uc003iek.2_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1294					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TCCTAATACTCAGGATAAGTC	0.403		NaN											0	0	0	0.00278	0	22	40									
SEMA5A	9037	broad.mit.edu	37	5	9122934	9122934	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr5:9122934C>T	uc003jek.2	-	14	2327	c.1615G>A	c.(1615-1617)GTG>ATG	p.V539M		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	539	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TGCCCATCCACGGTGAGATTC	0.517		NaN											0	0	0	0.01441	0	66	59									
DNAH5	1767	broad.mit.edu	37	5	13753535	13753535	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr5:13753535T>A	uc003jfd.2	-	63	10721	c.10679A>T	c.(10678-10680)AAC>ATC	p.N3560I	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3560					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GAGATTTAGGTTCTTTCCAAA	0.378		NaN							Kartagener_syndrome				0	0	0	0.006214	0	10	241									
DNAH5	1767	broad.mit.edu	37	5	13823473	13823473	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr5:13823473C>T	uc003jfd.2	-	40	6628	c.6586G>A	c.(6586-6588)GAG>AAG	p.E2196K		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2196					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GGTTCATCCTCATCAATCTAA	0.368		NaN							Kartagener_syndrome				0	0	0	0.008291	0	11	156									
CHSY3	337876	broad.mit.edu	37	5	129520760	129520760	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr5:129520760A>G	uc003kvd.2	+	3	1925	c.1925A>G	c.(1924-1926)GAA>GGA	p.E642G		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	642	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		GAGAACTTTGAAAACATGTGT	0.403		NaN											0	0	0	0.001168	0	4	69									
REEP2	51308	broad.mit.edu	37	5	137780945	137780945	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr5:137780945G>A	uc003lcz.2	+	6	562	c.440G>A	c.(439-441)CGC>CAC	p.R147H	REEP2_uc003lda.2_Missense_Mutation_p.R149H|REEP2_uc011cyt.1_Missense_Mutation_p.R108H	NM_016606	NP_057690	Q9BRK0	REEP2_HUMAN	receptor accessory protein 2	147						integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GAGAAGCTCCGCAGCTTCAGC	0.692		NaN											0	0	0	0.000602	0	5	56									
PCDHGB2	56103	broad.mit.edu	37	5	140741601	140741601	+	Silent	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr5:140741601C>T	uc003ljs.1	+	1	1899	c.1899C>T	c.(1897-1899)GGC>GGT	p.G633G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Silent_p.G633G|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	633	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCCTTGGGCGACAGGGACG	0.687		NaN											0	0	0	0.003163	0	10	16									
FLT4	2324	broad.mit.edu	37	5	180057288	180057288	+	Silent	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr5:180057288C>T	uc003mma.3	-	4	529	c.450G>A	c.(448-450)AGG>AGA	p.R150R	FLT4_uc003mlz.3_Silent_p.R150R|FLT4_uc003mmb.1_5'Flank|FLT4_uc011dgy.1_Silent_p.R150R|FLT4_uc011dgz.1_Silent_p.R150R|FLT4_uc011dha.1_Missense_Mutation_p.G134E	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	150	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGGCGTCCTTCCTGTTGACCA	0.632		NaN							Congenital_Hereditary_Lymphedema				0	0	0	0.004007	0	14	30									
TUBB	203068	broad.mit.edu	37	6	30691914	30691914	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr6:30691914C>T	uc003nrl.2	+	4	1202	c.1075C>T	c.(1075-1077)CGT>TGT	p.R359C	TUBB_uc003nrk.1_Missense_Mutation_p.R359C|TUBB_uc011dmq.1_Missense_Mutation_p.R287C	NM_178014	NP_821133	P07437	TBB5_HUMAN	tubulin, beta	359					cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding			ovary(1)	1					Colchicine(DB01394)|Vinblastine(DB00570)|Vincristine(DB00541)|Vinorelbine(DB00361)	CATCCCACCTCGTGGCCTCAA	0.532		NaN											0	0	0	0.00333	0	20	67									
ASCC3	10973	broad.mit.edu	37	6	100966000	100966000	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr6:100966000C>T	uc003pqk.2	-	38	6123	c.5794G>A	c.(5794-5796)GCA>ACA	p.A1932T		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1932	SEC63 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CCCTGGTTTGCAGCCACGTCC	0.478		NaN											0	0	0	0.000602	0	4	43									
SEC63	11231	broad.mit.edu	37	6	108193031	108193031	+	Silent	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr6:108193031C>T	uc003psc.3	-	21	2429	c.2160G>A	c.(2158-2160)AAG>AAA	p.K720K	SEC63_uc003psb.3_Silent_p.K547K	NM_007214	NP_009145	Q9UGP8	SEC63_HUMAN	SEC63-like protein	720	Cytoplasmic (Potential).				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			ovary(1)|skin(1)	2		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		CTGGCACAGGCTTAGCCTCAT	0.418		NaN											0	0	0	0.004482	0	8	93									
IYD	389434	broad.mit.edu	37	6	150713566	150713566	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr6:150713566C>G	uc003qnu.1	+	3	596	c.456C>G	c.(454-456)ATC>ATG	p.I152M	IYD_uc003qnv.1_Missense_Mutation_p.I152M|IYD_uc003qnw.1_RNA|IYD_uc003qnx.1_Missense_Mutation_p.I152M|IYD_uc010kik.1_Missense_Mutation_p.I70M	NM_203395	NP_981932	Q6PHW0	IYD1_HUMAN	iodotyrosine dehalogenase 1 isoform 2	152	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	integral to membrane|plasma membrane				ovary(2)	2		Ovarian(120;0.028)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;4.16e-12)		TTCGAAAGATCATTGAGGAGG	0.522		NaN											0	0	0	0.00308	0	8	65									
QKI	9444	broad.mit.edu	37	6	163984654	163984654	+	Silent	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr6:163984654C>T	uc003qui.2	+	6	1388	c.837C>T	c.(835-837)CCC>CCT	p.P279P	QKI_uc003que.2_Silent_p.P279P|QKI_uc003quf.2_Silent_p.P279P|QKI_uc003qug.2_Silent_p.P279P|QKI_uc003quh.2_Silent_p.P271P|QKI_uc003quj.2_Silent_p.P271P	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	279	SH3-binding.				mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		CTCCAGGGCCCGAAGCTGGTT	0.478		NaN											0	0	0	0.00245	0	15	64									
FAM126A	84668	broad.mit.edu	37	7	23016375	23016375	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr7:23016375C>A	uc003svm.3	-	6	722	c.467G>T	c.(466-468)GGT>GTT	p.G156V	FAM126A_uc003svn.3_Missense_Mutation_p.G12V|FAM126A_uc011jyr.1_Missense_Mutation_p.G122V	NM_032581	NP_115970	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	156						cytoplasm|membrane	signal transducer activity			central_nervous_system(1)	1						TTTTGACAAACCATGCTGGGA	0.418		NaN											1	0	2.0095e-06	0.001984	2.23666e-06	6	73									
CPA2	1358	broad.mit.edu	37	7	129908841	129908841	+	Silent	SNP	A	A	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr7:129908841A>G	uc003vpq.2	+	2	163	c.144A>G	c.(142-144)GAA>GAG	p.E48E	CPA2_uc011kpc.1_Silent_p.E48E	NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	48					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					AGGCTCAAGAACATCTCCAGG	0.373		NaN											0	0	0	0.009096	0	4	62									
SGK223	157285	broad.mit.edu	37	8	8185379	8185379	+	Silent	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr8:8185379G>A	uc003wsh.3	-	4	2913	c.2913C>T	c.(2911-2913)CTC>CTT	p.L971L		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	971							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						CGCCCATGAAGAGGTCCTCAC	0.562		NaN											0	0	0	0.00308	0	6	37									
FBXO16	157574	broad.mit.edu	37	8	28304779	28304779	+	Missense_Mutation	SNP	C	C	G	rs149234031	byFrequency	TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr8:28304779C>G	uc003xgu.2	-	7	850	c.752G>C	c.(751-753)AGA>ACA	p.R251T	ZNF395_uc003xgt.2_5'UTR|FBXO16_uc003xgv.2_Missense_Mutation_p.R238T|FBXO16_uc003xgw.2_Missense_Mutation_p.R238T	NM_172366	NP_758954	Q8IX29	FBX16_HUMAN	F-box only protein 16	251										ovary(1)	1		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		CATTTGGTTTCTTTTTCTTCT	0.353		NaN											0	0	0	0.008361	0	29	79									
ADHFE1	137872	broad.mit.edu	37	8	67357557	67357557	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr8:67357557C>T	uc003xwb.3	+	6	492	c.458C>T	c.(457-459)GCA>GTA	p.A153V	ADHFE1_uc003xwd.3_RNA|ADHFE1_uc003xwc.3_Missense_Mutation_p.A105V|ADHFE1_uc003xwe.3_RNA|ADHFE1_uc003xwf.3_Intron|ADHFE1_uc011les.1_Missense_Mutation_p.A83V|ADHFE1_uc011leq.1_Intron|ADHFE1_uc011ler.1_Intron	NM_144650	NP_653251	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	153					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			AATCTGTATGCATCCAGCCCT	0.488		NaN											0	0	0	0.008291	0	10	142									
VPS13B	157680	broad.mit.edu	37	8	100844794	100844794	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr8:100844794C>G	uc003yiv.2	+	52	9714	c.9603C>G	c.(9601-9603)AGC>AGG	p.S3201R	VPS13B_uc003yiw.2_Missense_Mutation_p.S3176R	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3201					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AGTGCTGGAGCCTGCCAGCTA	0.502		NaN											0	0	0	0.001168	0	5	94									
LRRC6	23639	broad.mit.edu	37	8	133584686	133584686	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr8:133584686G>T	uc003ytk.2	-	12	1343	c.1269C>A	c.(1267-1269)CAC>CAA	p.H423Q	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	423						cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CAGGGAATGAGTGCTTGCTAG	0.378		NaN											1	0	0.00307968	0.00308	0.00320487	8	208									
ZFAT	57623	broad.mit.edu	37	8	135615035	135615035	+	Silent	SNP	G	G	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr8:135615035G>T	uc003yup.2	-	6	1102	c.927C>A	c.(925-927)GCC>GCA	p.A309A	ZFAT_uc003yun.2_Silent_p.A297A|ZFAT_uc003yuo.2_Silent_p.A297A|ZFAT_uc010meh.2_Silent_p.A297A|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Silent_p.A297A|ZFAT_uc010mej.2_Silent_p.A247A|ZFAT_uc003yur.2_Silent_p.A297A	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	309	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TGGCCTTGATGGCACTGGCAT	0.562		NaN											1	0	0.000602214	0.000602	0.000631832	5	49									
MPDZ	8777	broad.mit.edu	37	9	13162702	13162702	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:13162702G>A	uc010mia.1	-	22	3404	c.3347C>T	c.(3346-3348)TCA>TTA	p.S1116L	MPDZ_uc010mhx.2_Missense_Mutation_p.S8L|MPDZ_uc011lmm.1_Missense_Mutation_p.S8L|MPDZ_uc003zkz.3_Intron|MPDZ_uc010mhy.2_Missense_Mutation_p.S1116L|MPDZ_uc010mhz.2_Missense_Mutation_p.S1116L|MPDZ_uc011lmn.1_Missense_Mutation_p.S1116L|MPDZ_uc003zlb.3_Missense_Mutation_p.S1116L	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1116					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		GCCAGTGTATGAAGAAAAAAT	0.378		NaN											0	0	0	0.006122	0	18	6									
RNF20	56254	broad.mit.edu	37	9	104314697	104314697	+	Silent	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:104314697G>A	uc004bbn.2	+	13	1653	c.1563G>A	c.(1561-1563)CAG>CAA	p.Q521Q		NM_019592	NP_062538	Q5VTR2	BRE1A_HUMAN	ring finger protein 20	521	Potential.				histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		CCCTCCTGCAGTCCCAGTCTA	0.498		NaN											0	0	0	0.006214	0	9	234									
KIAA0368	23392	broad.mit.edu	37	9	114176711	114176711	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:114176711C>T	uc004bfe.1	-	20	2519	c.2519G>A	c.(2518-2520)GGA>GAA	p.G840E	KIAA0368_uc010muc.1_Missense_Mutation_p.G662E	NM_001080398	NP_001073867			KIAA0368 protein												0						ATTCCTACCTCCAACACCTGC	0.413		NaN											0	0	0	0.00308	0	7	64									
NUP188	23511	broad.mit.edu	37	9	131755675	131755675	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:131755675G>C	uc004bws.1	+	26	2862	c.2840G>C	c.(2839-2841)GGC>GCC	p.G947A	NUP188_uc004bwu.2_Missense_Mutation_p.G290A	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	947					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						GGCAGTGATGGCTCAAAGGTA	0.522		NaN											0	0	0	0.004672	0	3	42									
POMT1	10585	broad.mit.edu	37	9	134381814	134381814	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:134381814A>G	uc004cav.2	+	4	456	c.254A>G	c.(253-255)AAT>AGT	p.N85S	POMT1_uc011mci.1_Missense_Mutation_p.N85S|POMT1_uc004cax.2_Missense_Mutation_p.N85S|POMT1_uc011mcj.1_Missense_Mutation_p.I3V|POMT1_uc004cau.2_Missense_Mutation_p.N85S|POMT1_uc004caw.2_Missense_Mutation_p.N31S|POMT1_uc011mck.1_5'UTR|POMT1_uc011mcl.1_5'UTR|POMT1_uc011mcm.1_Silent_p.Q49Q	NM_007171	NP_009102	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1 isoform a	85	Helical; (Potential).				multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		TTCGATGGCAATTTTTTGTGG	0.264		NaN											0	0	0	0.001855	0	10	238									
TTF1	7270	broad.mit.edu	37	9	135276961	135276961	+	Silent	SNP	G	G	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:135276961G>A	uc004cbl.2	-	2	1300	c.1248C>T	c.(1246-1248)AGC>AGT	p.S416S	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	416					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		CAAAGAGTGTGCTCTCAGAGT	0.463		NaN											0	0	0	0.001168	0	5	88									
COL5A1	1289	broad.mit.edu	37	9	137619185	137619185	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:137619185A>T	uc004cfe.2	+	5	1110	c.728A>T	c.(727-729)GAC>GTC	p.D243V		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	243	Nonhelical region.|Laminin G-like.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TACAGCCCTGACTGTGACACC	0.532		NaN											0	0	0	0.001984	0	7	68									
FBXW5	54461	broad.mit.edu	37	9	139837920	139837920	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:139837920C>A	uc004cjx.2	-	3	383	c.232G>T	c.(232-234)GAC>TAC	p.D78Y	FBXW5_uc010nbx.2_5'Flank|FBXW5_uc004cjy.2_5'UTR|FBXW5_uc004cjz.2_5'UTR|C8G_uc004cka.2_5'Flank	NM_018998	NP_061871	Q969U6	FBXW5_HUMAN	F-box and WD repeat domain containing 5	78							catalytic activity|protein binding				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		GGCACCGTGTCATACAGCCGC	0.657		NaN											1	0	3.07112e-06	0.010729	3.38882e-06	10	16									
STARD8	9754	broad.mit.edu	37	X	67940175	67940175	+	Silent	SNP	A	A	C			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chrX:67940175A>C	uc004dxa.2	+	7	2091	c.1719A>C	c.(1717-1719)CCA>CCC	p.P573P	STARD8_uc004dxb.2_Silent_p.P653P|STARD8_uc004dxc.3_Silent_p.P573P	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	573	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						TTGGGGTGCCACCCCTCATCC	0.577		NaN											0	0	0	0.001168	0	4	4									
SLC6A14	11254	broad.mit.edu	37	X	115573895	115573895	+	Silent	SNP	A	A	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chrX:115573895A>G	uc004eqi.2	+	4	491	c.387A>G	c.(385-387)ACA>ACG	p.T129T	SLC6A14_uc011mtm.1_Intron	NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	129	Helical; Name=3; (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	TTTTTGTGACAATCTATTACA	0.303		NaN											0	0	0	0.001855	0	13	79									
ODZ1	10178	broad.mit.edu	37	X	123556134	123556134	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chrX:123556134C>G	uc004euj.2	-	23	4502	c.4438G>C	c.(4438-4440)GAC>CAC	p.D1480H	ODZ1_uc011muj.1_Missense_Mutation_p.D1486H|ODZ1_uc010nqy.2_Missense_Mutation_p.D1487H	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1480	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GAAAAACAGTCACAGTTTGGA	0.438		NaN											0	0	0	0.004482	0	9	46									
TMEM184B	25829	broad.mit.edu	37	22	38626692	38626692	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr22:38626692delG	uc003avf.1	-	5	732	c.508delC	c.(508-510)CTGfs	p.L170fs	TMEM184B_uc003avg.1_Frame_Shift_Del_p.L170fs|TMEM184B_uc003avh.1_Frame_Shift_Del_p.L104fs|TMEM184B_uc010gxl.1_RNA	NM_012264	NP_036396	Q9Y519	T184B_HUMAN	transmembrane protein 184B	170						integral to membrane					0	Melanoma(58;0.045)					CAGAACCTCAGAAATCCGATG	0.607		NaN											NaN	NaN	NaN	NaN	NaN	7	13	---	---							
SYN2	6854	broad.mit.edu	37	3	12046124	12046126	+	In_Frame_Del	DEL	AGC	AGC	-	rs76272937		TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:12046124_12046126delAGC	uc003bwm.2	+	1	263_265	c.99_101delAGC	c.(97-102)CAACCG>CAG	p.P40del	SYN2_uc003bwl.1_In_Frame_Del_p.P40del	NM_133625	NP_598328	Q92777	SYN2_HUMAN	synapsin II isoform IIa	40					neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			ovary(1)|central_nervous_system(1)	2						AGCCCCAGCAAGCGCCGAcgccg	0.345		NaN											NaN	NaN	NaN	NaN	NaN	3	5	---	---							
AKAP9	10142	broad.mit.edu	37	7	91726612	91726613	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr7:91726612_91726613insA	uc003ulg.2	+	41	10564_10565	c.10339_10340insA	c.(10339-10341)GAAfs	p.E3447fs	AKAP9_uc003ulf.2_Frame_Shift_Ins_p.E3439fs|AKAP9_uc003uli.2_Frame_Shift_Ins_p.E3070fs|AKAP9_uc003ulj.2_Frame_Shift_Ins_p.E1217fs|AKAP9_uc003ull.2_Frame_Shift_Ins_p.E343fs	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3451	Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CCAGAAGCAAGAACTAGAACGA	0.376		NaN	T	BRAF	papillary thyroid								NaN	NaN	NaN	NaN	NaN	19	23	---	---							
