Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
CHD5	26038	broad.mit.edu	37	1	6219573	6219573	+	Silent	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:6219573C>T	uc001amb.1	-	3	310	c.210G>A	c.(208-210)GGG>GGA	p.G70G		NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	70	Lys-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CATCATTGCTCCCCTGGAAAA	0.507		NaN											0	0	0	0.038147	0	6	7									
TNFRSF25	8718	broad.mit.edu	37	1	6521714	6521714	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:6521714C>T	uc001ane.2	-	10	1122	c.1034G>A	c.(1033-1035)CGG>CAG	p.R345Q	TNFRSF25_uc001ana.2_Missense_Mutation_p.R162Q|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_Missense_Mutation_p.R118Q|TNFRSF25_uc009vlz.2_RNA|TNFRSF25_uc001anf.2_Missense_Mutation_p.R308Q|TNFRSF25_uc001ang.2_Missense_Mutation_p.R300Q|TNFRSF25_uc001anh.2_Missense_Mutation_p.R354Q	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	345	Death.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		CTTCCAGCGCCGCGCTGGGAC	0.692		NaN											0	0	0	0.115264	0	3	12									
RERE	473	broad.mit.edu	37	1	8418613	8418613	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:8418613C>T	uc001ape.2	-	21	4792	c.3982G>A	c.(3982-3984)GAG>AAG	p.E1328K	RERE_uc001apf.2_Missense_Mutation_p.E1328K|RERE_uc001apd.2_Missense_Mutation_p.E774K	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1328					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GGCTTCACCTCGAAGCCCGGC	0.721		NaN											0	0	0	0.043863	0	17	8									
ARID1A	8289	broad.mit.edu	37	1	27087417	27087417	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:27087417C>G	uc001bmv.1	+	5	2364	c.1991C>G	c.(1990-1992)TCA>TGA	p.S664*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.S664*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.S664*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.S281*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	664					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.S664*(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GTGAGCACATCAGGGATTTCC	0.517		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.139131	0	74	86									
PPCS	79717	broad.mit.edu	37	1	42925522	42925522	+	Silent	SNP	A	A	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:42925522A>G	uc001chl.2	+	3	925	c.861A>G	c.(859-861)AAA>AAG	p.K287K	PPCS_uc001chk.2_Silent_p.K114K	NM_024664	NP_078940	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase isoform	287					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AAATAGAAAAAGGCGTAGAGA	0.388		NaN											0	0	0	0.115264	0	3	93									
MYSM1	114803	broad.mit.edu	37	1	59127114	59127114	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:59127114G>T	uc009wab.1	-	18	2257	c.2234C>A	c.(2233-2235)ACA>AAA	p.T745K	uc001cza.2_5'Flank|MYSM1_uc009waa.1_Missense_Mutation_p.T151K|MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	745					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					TATCCATCTTGTCTTTTCAAA	0.373		NaN											1	0	0.00909568	0.150653	0.00923144	3	56									
PTGFR	5737	broad.mit.edu	37	1	78958573	78958573	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:78958573G>A	uc001din.2	+	2	411	c.145G>A	c.(145-147)GCC>ACC	p.A49T	PTGFR_uc001dim.2_Missense_Mutation_p.A49T	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	49	Helical; Name=1; (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	CCTTGCCATCGCCATTCTCAT	0.448		NaN											0	0	0	0.139131	0	61	49									
S1PR1	1901	broad.mit.edu	37	1	101705632	101705632	+	Silent	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:101705632C>T	uc001dud.2	+	2	1606	c.1092C>T	c.(1090-1092)GAC>GAT	p.D364D	S1PR1_uc009weg.2_Silent_p.D364D	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	364	Cytoplasmic (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						CCCAGAAAGACGAAGGGGACA	0.547		NaN											0	0	0	0.163468	0	29	55									
SNX27	81609	broad.mit.edu	37	1	151640977	151640977	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:151640977C>T	uc001eyn.1	+	7	1031	c.1015C>T	c.(1015-1017)CAC>TAC	p.H339Y	SNX27_uc001eyo.2_Missense_Mutation_p.H246Y|SNX27_uc001eyp.2_Missense_Mutation_p.H153Y	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	339	Ras-associating.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGAGTTTCCTCACAAACTCTA	0.363		NaN											0	0	0	0.163468	0	25	185									
HRNR	388697	broad.mit.edu	37	1	152188034	152188034	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:152188034C>G	uc001ezt.1	-	3	6147	c.6071G>C	c.(6070-6072)GGA>GCA	p.G2024A		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2024	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGATGACTGTCCTGATGCAGA	0.562		NaN											0	0	0	0.139131	0	84	269									
FLG	2312	broad.mit.edu	37	1	152277090	152277090	+	Silent	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:152277090G>A	uc001ezu.1	-	3	10308	c.10272C>T	c.(10270-10272)CAC>CAT	p.H3424H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3424	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGGACGCTGAGTGCCTGGAGC	0.597		NaN							Ichthyosis				0	0	0	0.139131	0	249	349									
FLG	2312	broad.mit.edu	37	1	152283897	152283897	+	Silent	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:152283897G>A	uc001ezu.1	-	3	3501	c.3465C>T	c.(3463-3465)CAC>CAT	p.H1155H	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1155	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGGACGCTGAGTGCCTGGAGC	0.597		NaN							Ichthyosis				0	0	0	0.139131	0	15	616									
C1orf129	80133	broad.mit.edu	37	1	170961422	170961422	+	Silent	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:170961422G>A	uc001ghg.2	+	12	1276	c.1146G>A	c.(1144-1146)ACG>ACA	p.T382T	C1orf129_uc009wvy.2_Silent_p.T189T|C1orf129_uc010plz.1_Silent_p.T382T	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	382							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ACACCGTAACGGAAGGGAAAC	0.473		NaN											0	0	0	0.108266	0	23	118									
SYT14	255928	broad.mit.edu	37	1	210334177	210334177	+	Silent	SNP	T	T	C			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:210334177T>C	uc009xcv.2	+	8	1530	c.1458T>C	c.(1456-1458)ACT>ACC	p.T486T	SYT14_uc001hhs.3_Silent_p.T550T|SYT14_uc001hht.3_Silent_p.T505T|SYT14_uc001hhu.3_RNA|SYT14_uc010psn.1_Silent_p.T531T|SYT14_uc010pso.1_Silent_p.T448T|SYT14_uc010psp.1_Silent_p.T24T	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	486	Cytoplasmic (Potential).|C2 2.					integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		ATAAGGAAACTTTTGTCTTTC	0.408		NaN											0	0	0	0.139131	0	73	12									
KLF6	1316	broad.mit.edu	37	10	3823885	3823885	+	Silent	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr10:3823885C>T	uc001iha.2	-	2	891	c.624G>A	c.(622-624)AGG>AGA	p.R208R	KLF6_uc010qaj.1_Silent_p.R208R|KLF6_uc010qak.1_Intron|KLF6_uc010qal.1_Intron|KLF6_uc001ihb.2_Silent_p.R208R	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	208	C2H2-type 1.				B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		TGTAAACTTTCCTGCAGCCGT	0.657		NaN									OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.150653	0	4	56									
KLF6	1316	broad.mit.edu	37	10	3824277	3824277	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr10:3824277C>A	uc001iha.2	-	2	499	c.232G>T	c.(232-234)GAA>TAA	p.E78*	KLF6_uc010qaj.1_Nonsense_Mutation_p.E78*|KLF6_uc010qak.1_RNA|KLF6_uc010qal.1_Nonsense_Mutation_p.E78*|KLF6_uc001ihb.2_Nonsense_Mutation_p.E78*	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	78					B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		ATCTTCAGTTCGGATTCCTCC	0.483		NaN									OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	0.00278032	0.076483	0.00288644	23	159									
ERCC6	2074	broad.mit.edu	37	10	50669504	50669504	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr10:50669504C>T	uc001jhs.3	-	19	4031	c.3877G>A	c.(3877-3879)GCC>ACC	p.A1293T	ERCC6_uc009xod.2_Missense_Mutation_p.A453T|ERCC6_uc010qgr.1_Missense_Mutation_p.A663T|ERCC6_uc001jhr.3_Missense_Mutation_p.A661T	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1293					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						GCTTTCAGGGCATCCTGGGCC	0.592		NaN						Direct_reversal_of_damage|NER					0	0	0	0.069288	0	21	28									
SH2D4B	387694	broad.mit.edu	37	10	82403797	82403797	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr10:82403797G>A	uc001kck.1	+	7	1464	c.1034G>A	c.(1033-1035)CGG>CAG	p.R345Q	SH2D4B_uc001kcl.1_Missense_Mutation_p.R297Q|SH2D4B_uc001kcm.1_Missense_Mutation_p.G166R|SH2D4B_uc001kcn.1_RNA	NM_207372	NP_997255	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B isoform 1	Error:Variant_position_missing_in_Q5SQS7_after_alignment											0			Colorectal(32;0.229)			GGAACCCTGCGGACAGAGGGA	0.373		NaN											0	0	0	0.062417	0	14	59									
NRG3	10718	broad.mit.edu	37	10	84498404	84498404	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr10:84498404C>T	uc001kco.2	+	3	1052	c.1025C>T	c.(1024-1026)CCA>CTA	p.P342L	NRG3_uc010qlz.1_Missense_Mutation_p.P342L|NRG3_uc001kcp.2_Missense_Mutation_p.P121L|NRG3_uc001kcq.2_5'UTR	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	342	Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		TTATCGGATCCAAGTAGGTCA	0.393		NaN											0	0	0	0.014758	0	4	44									
PIK3AP1	118788	broad.mit.edu	37	10	98411088	98411088	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr10:98411088G>C	uc001kmq.2	-	6	1033	c.905C>G	c.(904-906)ACC>AGC	p.T302S	PIK3AP1_uc001kmp.2_Missense_Mutation_p.T124S	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	302	DBB.					cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		CAGGGATTCGGTTAGCAGTTT	0.428		NaN											0	0	0	0.160694	0	16	36									
RRP12	23223	broad.mit.edu	37	10	99133483	99133483	+	Silent	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr10:99133483G>A	uc001knf.2	-	17	2014	c.1875C>T	c.(1873-1875)CTC>CTT	p.L625L	RRP12_uc009xvl.2_5'UTR|RRP12_uc009xvm.2_Silent_p.L343L|RRP12_uc010qou.1_Silent_p.L564L|RRP12_uc009xvn.2_Silent_p.L525L	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	625						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		ACCCAGGCAGGAGTGTCCACA	0.622		NaN											0	0	0	0.080422	0	34	12									
OR9Q2	219957	broad.mit.edu	37	11	57958327	57958327	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr11:57958327G>A	uc010rka.1	+	1	365	c.365G>A	c.(364-366)CGC>CAC	p.R122H		NM_001005283	NP_001005283	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)|central_nervous_system(1)	4		Breast(21;0.0589)				GCCTATGACCGCTACACGGCC	0.567		NaN											0	0	0	0.139131	0	45	88									
MPEG1	219972	broad.mit.edu	37	11	58980208	58980208	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr11:58980208T>C	uc001nnu.3	-	1	287	c.131A>G	c.(130-132)GAA>GGA	p.E44G		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1 precursor	44	MACPF.|Extracellular (Potential).					integral to membrane				ovary(1)|skin(1)	2		all_epithelial(135;0.125)				AGGTAGGACTTCCAGGACAGG	0.522		NaN											0	0	0	0.014758	0	5	244									
SCGB1D1	10648	broad.mit.edu	37	11	61959667	61959667	+	Silent	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr11:61959667C>T	uc001nsz.1	+	2	242	c.195C>T	c.(193-195)TGC>TGT	p.C65C		NM_006552	NP_006543	O95968	SG1D1_HUMAN	lipophilin A precursor	65						extracellular space	binding			skin(1)	1						TGAAGAAATGCGTGGATACGA	0.443		NaN											0	0	0	0.139131	0	83	65									
GANAB	23193	broad.mit.edu	37	11	62393905	62393905	+	Silent	SNP	T	T	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr11:62393905T>A	uc001nub.2	-	22	2559	c.2526A>T	c.(2524-2526)GGA>GGT	p.G842G	GANAB_uc001ntz.2_Silent_p.G29G|GANAB_uc001nua.2_Silent_p.G864G|GANAB_uc001nuc.2_Silent_p.G745G|GANAB_uc010rma.1_Silent_p.G750G|GANAB_uc010rmb.1_Silent_p.G728G	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	842					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						GAAAGAGCTCTCCTTGAGCTG	0.552		NaN											0	0	0	0.074837	0	29	79									
PLCB3	5331	broad.mit.edu	37	11	64033975	64033975	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr11:64033975C>A	uc001nzb.2	+	29	3365	c.3365C>A	c.(3364-3366)ACG>AAG	p.T1122K	PLCB3_uc009ypg.1_Missense_Mutation_p.T1122K|PLCB3_uc009yph.1_Missense_Mutation_p.T1055K|PLCB3_uc009ypi.2_Missense_Mutation_p.T1122K	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	1122					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						AGGGAACTGACGGAGATTAAC	0.652		NaN											1	0	6.21321e-17	0.076483	7.10081e-17	20	90									
KDELC2	143888	broad.mit.edu	37	11	108357060	108357060	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr11:108357060A>G	uc001pkj.2	-	3	574	c.508T>C	c.(508-510)TTT>CTT	p.F170L	KDELC2_uc001pki.2_Missense_Mutation_p.F114L	NM_153705	NP_714916	Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2 precursor	170						endoplasmic reticulum lumen				ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		ATGCTGGGAAAGGAAGCAAAA	0.453		NaN											0	0	0	0.150653	0	4	63									
ACRBP	84519	broad.mit.edu	37	12	6756060	6756060	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:6756060C>A	uc001qpu.1	-	2	210	c.162G>T	c.(160-162)TGG>TGT	p.W54C	ACRBP_uc010sfg.1_Missense_Mutation_p.W54C	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	54						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						TCTCTGCCTTCCAGGTTGGAG	0.602		NaN											1	0	0.00909568	0.150653	0.00923144	4	78									
IFLTD1	160492	broad.mit.edu	37	12	25672949	25672949	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:25672949C>T	uc001rgs.2	-	6	946	c.796G>A	c.(796-798)GTT>ATT	p.V266I	IFLTD1_uc001rgt.1_Missense_Mutation_p.V169I|IFLTD1_uc010sji.1_Missense_Mutation_p.V287I|IFLTD1_uc010sjj.1_Missense_Mutation_p.V203I|IFLTD1_uc009zjc.2_Missense_Mutation_p.V247I	NM_152590	NP_689803	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	266						intermediate filament	structural molecule activity			ovary(2)|central_nervous_system(1)	3	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					TTAAATTCAACGTCAGCATCT	0.373		NaN											0	0	0	0.153744	0	29	34									
PTHLH	5744	broad.mit.edu	37	12	28116292	28116292	+	Silent	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:28116292C>T	uc001rik.2	-	3	816	c.513G>A	c.(511-513)GAG>GAA	p.E171E	PTHLH_uc001ril.2_Silent_p.E171E|PTHLH_uc001rim.2_Silent_p.E171E|PTHLH_uc001rin.2_Silent_p.E171E	NM_198966	NP_945317	P12272	PTHR_HUMAN	parathyroid hormone-like hormone isoform 1	171					activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding			breast(1)	1	Lung SC(9;0.184)					GTGAATCGAGCTCCAGCGACG	0.582		NaN											0	0	0	0.069288	0	17	33									
MLL2	8085	broad.mit.edu	37	12	49424741	49424741	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:49424741G>A	uc001rta.3	-	40	13606	c.13606C>T	c.(13606-13608)CGA>TGA	p.R4536*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4536					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGCTTCTTTCGGGAGCTCACC	0.592		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.058154	0	7	25									
FAM19A2	338811	broad.mit.edu	37	12	62148677	62148677	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:62148677G>A	uc001sqw.2	-	3	1748	c.235C>T	c.(235-237)CGA>TGA	p.R79*	FAM19A2_uc001sqv.2_RNA|FAM19A2_uc001sqx.2_Nonsense_Mutation_p.R79*|FAM19A2_uc001sqy.2_RNA	NM_178539	NP_848634	Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine	79						cytoplasm				ovary(1)	1			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		GGAGCAGCTCGCGTGGTGCCT	0.502		NaN											0	0	0	0.153744	0	25	17									
POLR3B	55703	broad.mit.edu	37	12	106824210	106824210	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:106824210C>A	uc001tlp.2	+	14	1645	c.1423C>A	c.(1423-1425)CAG>AAG	p.Q475K	POLR3B_uc001tlq.2_Missense_Mutation_p.Q417K	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	475					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						CCAGCCATCTCAGTGGGGAAT	0.493		NaN											1	0	2.7689e-08	0.02938	3.01256e-08	4	114									
CUX2	23316	broad.mit.edu	37	12	111786052	111786052	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:111786052A>G	uc001tsa.1	+	22	4537	c.4384A>G	c.(4384-4386)ATG>GTG	p.M1462V		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1462						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GCATGAGAAGATGGCCAATCT	0.612		NaN											0	0	0	0.131918	0	39	220									
DNAH10	196385	broad.mit.edu	37	12	124354930	124354930	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:124354930T>C	uc001uft.3	+	43	7208	c.7183T>C	c.(7183-7185)TAT>CAT	p.Y2395H		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2395					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCCAACCTTGTATGACTTTCA	0.388		NaN											0	0	0	0.049695	0	20	21									
POLR1D	51082	broad.mit.edu	37	13	28197152	28197152	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr13:28197152G>C	uc010tdm.1	+	3	1197	c.167G>C	c.(166-168)CGT>CCT	p.R56P	LNX2_uc001url.3_5'Flank|LNX2_uc001urm.1_5'Flank|POLR1D_uc010aam.2_Intron|POLR1D_uc001urq.2_Intron|POLR1D_uc001uro.2_Missense_Mutation_p.R56P|POLR1D_uc001urp.2_Intron	NM_015972	NP_057056	Q9Y2S0	RPAC2_HUMAN	polymerase (RNA) I polypeptide D isoform 1	56			R -> C (in TCS2).		termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0758)|OV - Ovarian serous cystadenocarcinoma(117;0.1)|Epithelial(112;0.213)		AATTCTCTACGTTACATGATC	0.453		NaN											0	0	0	0.049695	0	17	52									
SLC7A1	6541	broad.mit.edu	37	13	30091860	30091860	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr13:30091860C>T	uc001uso.2	-	10	1747	c.1360G>A	c.(1360-1362)GAC>AAC	p.D454N		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	454	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	TCATTTTGGTCTGCTGGATCT	0.493		NaN											0	0	0	0.108266	0	24	85									
BRCA2	675	broad.mit.edu	37	13	32910615	32910615	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr13:32910615C>A	uc001uub.1	+	11	2350	c.2123C>A	c.(2122-2124)TCT>TAT	p.S708Y		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	708	Interaction with NPM1.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GAAGCTGATTCTCTGTCATGC	0.358		NaN	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			1	0	3.86212e-05	0.069234	4.1035e-05	11	32									
FGF14	2259	broad.mit.edu	37	13	103053996	103053996	+	Silent	SNP	A	A	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr13:103053996A>T	uc001vpf.2	-	1	129	c.33T>A	c.(31-33)ACT>ACA	p.T11T		NM_175929	NP_787125	Q92915	FGF14_HUMAN	fibroblast growth factor 14 isoform 1B	Error:Variant_position_missing_in_Q92915_after_alignment					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			ovary(2)|lung(1)|large_intestine(1)	4	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ATTTGAAATCAGTTCTCCTGA	0.413		NaN											0	0	0	0.074837	0	30	3									
PTGDR	5729	broad.mit.edu	37	14	52735003	52735003	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr14:52735003C>A	uc001wzq.2	+	1	573	c.471C>A	c.(469-471)AGC>AGA	p.S157R		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	157	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	CGGTGGTGAGCGCCTTCTCCC	0.637		NaN											1	0	0.00024832	0.150653	0.000259781	3	55									
AHNAK2	113146	broad.mit.edu	37	14	105416701	105416701	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr14:105416701G>T	uc010axc.1	-	7	5207	c.5087C>A	c.(5086-5088)TCC>TAC	p.S1696Y	AHNAK2_uc001ypx.2_Missense_Mutation_p.S1596Y	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1696						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCCTGCATGGAGGGGAGGCT	0.612		NaN											1	0	6.72482e-11	0.132662	7.55848e-11	7	272									
OCA2	4948	broad.mit.edu	37	15	28231744	28231744	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr15:28231744A>G	uc001zbh.3	-	12	1338	c.1228T>C	c.(1228-1230)TGT>CGT	p.C410R	OCA2_uc010ayv.2_Missense_Mutation_p.C386R	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	410	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		TTTACAGCACAATAATCGAAA	0.284		NaN							Oculocutaneous_Albinism				0	0	0	0.139131	0	63	23									
MYO5A	4644	broad.mit.edu	37	15	52662482	52662482	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr15:52662482G>A	uc002aby.2	-	22	3194	c.2950C>T	c.(2950-2952)CGG>TGG	p.R984W	MYO5A_uc002abx.3_Missense_Mutation_p.R984W|MYO5A_uc010uge.1_Missense_Mutation_p.R853W	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	984	Potential.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CTAAGGACCCGCCCAGTGGCA	0.448		NaN											0	0	0	0.11126	0	41	7									
CCDC78	124093	broad.mit.edu	37	16	775562	775562	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr16:775562G>A	uc002cjg.2	-	4	392	c.286C>T	c.(286-288)CGG>TGG	p.R96W	CCDC78_uc002cjf.2_5'Flank|CCDC78_uc002cji.3_Missense_Mutation_p.R170W|CCDC78_uc002cjj.3_Intron|CCDC78_uc002cjh.2_5'UTR|CCDC78_uc010uuo.1_Missense_Mutation_p.R96W|CCDC78_uc002cjk.2_Missense_Mutation_p.R96W|HAGHL_uc002cjl.1_5'Flank|HAGHL_uc002cjm.1_5'Flank|HAGHL_uc002cjn.1_5'Flank|HAGHL_uc002cjo.1_5'Flank|HAGHL_uc010uup.1_5'Flank	NM_001031737	NP_001026907	A2IDD5	CCD78_HUMAN	coiled-coil domain containing 78	96	Potential.									central_nervous_system(1)	1		Hepatocellular(780;0.0218)				TCCAGTACCCGGCTCTCCAGC	0.662		NaN											0	0	0	0.080422	0	30	2									
SH2B1	25970	broad.mit.edu	37	16	28877696	28877696	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr16:28877696C>T	uc002dri.2	+	4	720	c.281C>T	c.(280-282)CCC>CTC	p.P94L	uc010vct.1_Intron|SH2B1_uc010vdc.1_Intron|SH2B1_uc002drj.2_Missense_Mutation_p.P94L|SH2B1_uc002drk.2_Missense_Mutation_p.P94L|SH2B1_uc002drl.2_Missense_Mutation_p.P94L|SH2B1_uc010vdd.1_Intron|SH2B1_uc010vde.1_Missense_Mutation_p.P94L|SH2B1_uc002drm.2_Missense_Mutation_p.P94L	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	94	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|Interaction with RAC1 (By similarity).				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						ATCCTGGCTCCCCTGAGCCCT	0.652		NaN											0	0	0	0.160694	0	15	16									
ATMIN	23300	broad.mit.edu	37	16	81078139	81078139	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr16:81078139C>G	uc002ffz.1	+	4	2054	c.2036C>G	c.(2035-2037)GCA>GGA	p.A679G	ATMIN_uc002fga.2_Missense_Mutation_p.A521G|ATMIN_uc010vnn.1_Missense_Mutation_p.A450G|ATMIN_uc002fgb.1_Missense_Mutation_p.A521G	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	679					response to DNA damage stimulus	nucleus	zinc ion binding				0						TTCTTACTCGCAGATACCTCT	0.443		NaN											0	0	0	0.173368	0	33	141									
OR3A1	4994	broad.mit.edu	37	17	3195282	3195282	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:3195282C>T	uc002fvh.1	-	1	595	c.595G>A	c.(595-597)GAG>AAG	p.E199K		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	199	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						AGCAGCAGCTCATTGAGTTGG	0.522		NaN											0	0	0	0.021553	0	5	94									
C17orf74	201243	broad.mit.edu	37	17	7329763	7329763	+	Silent	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:7329763C>T	uc002ggw.2	+	3	526	c.453C>T	c.(451-453)ATC>ATT	p.I151I	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	151						integral to membrane					0		Prostate(122;0.157)				ACAGACAAATCCCCCATAGCC	0.413		NaN											0	0	0	0.074837	0	36	27									
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	G	A	rs121913343		TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.043863	0	19	3									
ATP6V0A1	535	broad.mit.edu	37	17	40660605	40660605	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:40660605G>A	uc002hzr.2	+	19	2295	c.2128G>A	c.(2128-2130)GTG>ATG	p.V710M	ATP6V0A1_uc002hzq.2_Intron|ATP6V0A1_uc002hzs.2_Intron|ATP6V0A1_uc010wgj.1_Missense_Mutation_p.V667M|ATP6V0A1_uc010wgk.1_Intron|ATP6V0A1_uc010cyg.2_Missense_Mutation_p.V356M|ATP6V0A1_uc010wgl.1_Missense_Mutation_p.V569M|ATP6V0A1_uc002hzt.2_Intron	NM_001130021	NP_001123493	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	710	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		CGAGGACGAAGTGGTAAGATG	0.517		NaN											0	0	0	0.139131	0	47	44									
AOC3	8639	broad.mit.edu	37	17	41008400	41008400	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:41008400A>C	uc002ibv.2	+	4	2285	c.2125A>C	c.(2125-2127)AAC>CAC	p.N709H		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	709	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	CCGACCCTATAACTTCTTTGA	0.572		NaN											0	0	0	0.09319	0	10	76									
ZNF652	22834	broad.mit.edu	37	17	47388796	47388796	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:47388796T>C	uc002iov.3	-	5	1651	c.1187A>G	c.(1186-1188)TAC>TGC	p.Y396C	ZNF652_uc002iow.2_Missense_Mutation_p.Y396C|ZNF652_uc002iou.3_RNA	NM_001145365	NP_001138837	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	396	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			CTGGTACTTGTACTGAAACCT	0.458		NaN											0	0	0	0.139131	0	106	160									
NXPH3	11248	broad.mit.edu	37	17	47656111	47656111	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:47656111G>A	uc002ipa.2	+	2	492	c.208G>A	c.(208-210)GCC>ACC	p.A70T	NXPH3_uc010wlw.1_Missense_Mutation_p.A70T	NM_007225	NP_009156	O95157	NXPH3_HUMAN	neurexophilin 3 precursor	70	II.				neuropeptide signaling pathway	extracellular region				pancreas(1)|skin(1)	2	all_cancers(4;7.45e-14)|Breast(4;1.08e-27)|all_epithelial(4;2.27e-17)					AGGGCTGCTGGCCCCGCCTGG	0.682		NaN											0	0	0	0.131918	0	40	48									
GPR142	350383	broad.mit.edu	37	17	72363883	72363883	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:72363883G>A	uc010wqy.1	+	1	239	c.239G>A	c.(238-240)CGC>CAC	p.R80H	GPR142_uc010wqx.1_5'UTR	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	80	Extracellular (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						AGCAGTTTCCGCCAGGTGAAT	0.562		NaN											0	0	0	0.125774	0	26	28									
TCF4	6925	broad.mit.edu	37	18	53254339	53254339	+	Silent	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr18:53254339G>A	uc002lfz.2	-	2	621	c.9C>T	c.(7-9)CAC>CAT	p.H3H	TCF4_uc010xdx.1_5'Flank|TCF4_uc010dph.1_Silent_p.H3H|TCF4_uc010xdy.1_Intron|TCF4_uc002lga.2_Silent_p.H105H|TCF4_uc010dpi.2_Silent_p.H3H	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	3	Essential for MYOD1 inhibition (By similarity).				positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		TTCGCTGTTGGTGATGCATTT	0.423		NaN											0	0	0	0.131918	0	37	14									
TMPRSS9	360200	broad.mit.edu	37	19	2403105	2403105	+	Silent	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:2403105C>T	uc010xgx.1	+	5	480	c.480C>T	c.(478-480)TCC>TCT	p.S160S	TMPRSS9_uc002lvv.1_Silent_p.S194S	NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	160	LDL-receptor class A.|Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTCCTTTTCCTGCGGGAACA	0.572		NaN											0	0	0	0.160694	0	12	8									
DIRAS1	148252	broad.mit.edu	37	19	2717599	2717599	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:2717599G>A	uc002lwf.3	-	2	364	c.206C>T	c.(205-207)CCG>CTG	p.P69L		NM_145173	NP_660156	O95057	DIRA1_HUMAN	DIRAS family, GTP-binding RAS-like 1	69					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCATGGCCGGGAACTGGTG	0.622		NaN											0	0	0	0.115264	0	3	38									
MUC16	94025	broad.mit.edu	37	19	9061676	9061676	+	Silent	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:9061676C>T	uc002mkp.2	-	3	25974	c.25770G>A	c.(25768-25770)GTG>GTA	p.V8590V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8592	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAAGTGCAGTCACAGGATGAG	0.507		NaN											0	0	0	0.099896	0	26	15									
CNN1	1264	broad.mit.edu	37	19	11660528	11660528	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:11660528A>C	uc002msc.1	+	7	976	c.812A>C	c.(811-813)AAG>ACG	p.K271T	CNN1_uc010xmb.1_Missense_Mutation_p.K221T|CNN1_uc010xmc.1_Missense_Mutation_p.K221T	NM_001299	NP_001290	P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	271					actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding				0						TACGACCCCAAGTACTGTCTG	0.622		NaN											0	0	0	0.132662	0	13	73									
ZNF208	7757	broad.mit.edu	37	19	22155320	22155320	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:22155320C>T	uc002nqp.2	-	5	2365	c.2216G>A	c.(2215-2217)GGC>GAC	p.G739D	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				AAAGGCTTTGCCACATTCTTT	0.373		NaN											0	0	0	0.160694	0	17	67									
KIAA0355	9710	broad.mit.edu	37	19	34810899	34810899	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:34810899T>C	uc002nvd.3	+	3	1442	c.583T>C	c.(583-585)TCT>CCT	p.S195P		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	195										ovary(1)	1	Esophageal squamous(110;0.162)					GGTGGCTCACTCTTGCTTTGC	0.532		NaN											0	0	0	0.150653	0	3	140									
CYP2A13	1553	broad.mit.edu	37	19	41594393	41594393	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:41594393T>G	uc002opt.2	+	1	26	c.17T>G	c.(16-18)CTG>CGG	p.L6R		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	6					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	GCCTCAGGGCTGCTTCTGGTG	0.572		NaN											0	0	0	0.11911	0	11	32									
CADM4	199731	broad.mit.edu	37	19	44129330	44129330	+	Silent	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:44129330G>A	uc002oxc.1	-	7	877	c.828C>T	c.(826-828)CTC>CTT	p.L276L		NM_145296	NP_660339	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4 precursor	276	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion	integral to membrane					0		Prostate(69;0.0199)				CCGGCAGCGTGAGCGTCTCTC	0.607		NaN											0	0	0	0.0918	0	24	22									
LTBP1	4052	broad.mit.edu	37	2	33359935	33359935	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr2:33359935G>C	uc002ros.2	+	5	1109	c.1109G>C	c.(1108-1110)TGT>TCT	p.C370S	LTBP1_uc002rot.2_Missense_Mutation_p.C44S|LTBP1_uc002rou.2_Missense_Mutation_p.C44S|LTBP1_uc002rov.2_Missense_Mutation_p.C44S|LTBP1_uc010ymz.1_Missense_Mutation_p.C44S|LTBP1_uc010yna.1_Missense_Mutation_p.C44S	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	370					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AAGGGCAGCTGTCAGAACAGC	0.547		NaN											0	0	0	0.160694	0	16	58									
AFF3	3899	broad.mit.edu	37	2	100623238	100623238	+	Silent	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr2:100623238C>T	uc002tag.2	-	6	965	c.729G>A	c.(727-729)CAG>CAA	p.Q243Q	AFF3_uc002taf.2_Silent_p.Q268Q|AFF3_uc010fiq.1_Silent_p.Q243Q|AFF3_uc010yvr.1_Silent_p.Q397Q|AFF3_uc002tah.1_Silent_p.Q268Q|AFF3_uc010fir.1_Silent_p.Q320Q|AFF3_uc002tai.2_Silent_p.Q165Q	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	243					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CATCAGGGGCCTGATCTTGGC	0.572		NaN											0	0	0	0.055883	0	21	8									
BUB1	699	broad.mit.edu	37	2	111395670	111395670	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr2:111395670A>T	uc002tgc.2	-	25	3241	c.3129T>A	c.(3127-3129)CAT>CAA	p.H1043Q	BUB1_uc010yxh.1_Missense_Mutation_p.H1023Q|BUB1_uc010fkb.2_Missense_Mutation_p.H986Q	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	1043	Protein kinase.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		AAGATGGAAGATGATGACAAT	0.333		NaN											0	0	0	0.150653	0	4	35									
NCOA6	23054	broad.mit.edu	37	20	33329786	33329786	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr20:33329786C>A	uc002xav.2	-	12	6845	c.4274G>T	c.(4273-4275)AGT>ATT	p.S1425I	NCOA6_uc002xaw.2_Missense_Mutation_p.S1425I	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1425					brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						CTGGCAATCACTGTCCTGAGG	0.468		NaN											1	0	4.7546e-09	0.146539	5.30021e-09	15	96									
RBL1	5933	broad.mit.edu	37	20	35724278	35724278	+	Silent	SNP	C	C	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr20:35724278C>A	uc002xgi.2	-	1	133	c.54G>T	c.(52-54)GGG>GGT	p.G18G	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Silent_p.G18G|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	18					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				GTAGCGCCTCCCCGGCTGCGG	0.697		NaN											1	0	3.09899e-07	0.047766	3.34494e-07	5	4									
ZNF831	128611	broad.mit.edu	37	20	57767397	57767397	+	Silent	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr20:57767397C>T	uc002yan.2	+	1	1323	c.1323C>T	c.(1321-1323)GAC>GAT	p.D441D		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	441						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GCAGCATCGACCTGCCCACGC	0.677		NaN											0	0	0	0.021553	0	5	23									
HDAC11	79885	broad.mit.edu	37	3	13522882	13522882	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr3:13522882A>C	uc003bxy.2	+	2	272	c.139A>C	c.(139-141)AAT>CAT	p.N47H	HDAC11_uc010heb.2_Missense_Mutation_p.N19H|HDAC11_uc011aux.1_5'UTR|HDAC11_uc003bxz.2_Missense_Mutation_p.N19H|HDAC11_uc011auy.1_Missense_Mutation_p.N19H	NM_024827	NP_079103	Q96DB2	HDA11_HUMAN	histone deacetylase 11 isoform 1	47	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			ovary(2)	2						CAAAGTGATCAATTTCCTAAA	0.542		NaN											0	0	0	0.139131	0	52	149									
ZNF445	353274	broad.mit.edu	37	3	44488285	44488285	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr3:44488285T>G	uc003cnf.2	-	8	3226	c.2878A>C	c.(2878-2880)AGC>CGC	p.S960R	ZNF445_uc011azv.1_Missense_Mutation_p.S948R|ZNF445_uc011azw.1_Missense_Mutation_p.S960R	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	960					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		GAGCTCTGGCTGCAAGCTTCT	0.478		NaN											0	0	0	0.055883	0	20	63									
PDZRN3	23024	broad.mit.edu	37	3	73433184	73433184	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr3:73433184C>T	uc003dpl.1	-	10	2629	c.2533G>A	c.(2533-2535)GGG>AGG	p.G845R	PDZRN3_uc011bgh.1_Missense_Mutation_p.G502R|PDZRN3_uc010hoe.1_Missense_Mutation_p.G543R|PDZRN3_uc011bgf.1_Missense_Mutation_p.G562R|PDZRN3_uc011bgg.1_Missense_Mutation_p.G565R	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	845							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CTCCGGCTCCCGTCGCTGGCT	0.667		NaN											0	0	0	0.146539	0	14	11									
PARP14	54625	broad.mit.edu	37	3	122446797	122446797	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr3:122446797C>T	uc003efq.3	+	16	5139	c.5080C>T	c.(5080-5082)CGA>TGA	p.R1694*	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Nonsense_Mutation_p.R1411*	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1694	PARP catalytic.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		ACACGTCAATCGAAATGGCTT	0.507		NaN											0	0	0	0.173368	0	28	35									
MYLK	4638	broad.mit.edu	37	3	123419212	123419212	+	Silent	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr3:123419212G>A	uc003ego.2	-	18	3385	c.3103C>T	c.(3103-3105)CTG>TTG	p.L1035L	MYLK_uc011bjw.1_Silent_p.L1035L|MYLK_uc003egp.2_Silent_p.L966L|MYLK_uc003egq.2_Silent_p.L1035L|MYLK_uc003egr.2_Silent_p.L966L|MYLK_uc003egs.2_Silent_p.L859L|MYLK_uc003egt.2_Silent_p.L226L	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1035	2-4.|6 X 12 AA approximate tandem repeats.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ATTGGCTTCAGGGTCTCAGCA	0.577		NaN											0	0	0	0.139131	0	112	124									
ZIC4	84107	broad.mit.edu	37	3	147114157	147114157	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr3:147114157C>T	uc003ewd.1	-	3	443	c.170G>A	c.(169-171)CGT>CAT	p.R57H	ZIC4_uc003ewc.1_5'UTR|ZIC4_uc011bno.1_Missense_Mutation_p.R107H	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	57						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						ATTCAAAGGACGGCTGGGGGA	0.726		NaN											0	0	0	0.11911	0	12	32									
GABRA4	2557	broad.mit.edu	37	4	46930266	46930266	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr4:46930266C>T	uc003gxg.2	-	9	1780	c.1641G>A	c.(1639-1641)ATG>ATA	p.M547I		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	547					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTGATTTCTCCATAGTGTCCT	0.294		NaN											0	0	0	0.150653	0	3	119									
MUC7	4589	broad.mit.edu	37	4	71347033	71347033	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr4:71347033C>T	uc011cat.1	+	4	860	c.572C>T	c.(571-573)GCC>GTC	p.A191V	MUC7_uc011cau.1_Missense_Mutation_p.A191V|MUC7_uc003hfj.2_Missense_Mutation_p.A191V|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	191	2.|Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			ACCACAGCTGCCCCACCCACA	0.587		NaN											0	0	0	0.150653	0	4	154									
EXOSC9	5393	broad.mit.edu	37	4	122728756	122728756	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr4:122728756G>A	uc003iea.2	+	6	692	c.584G>A	c.(583-585)AGT>AAT	p.S195N	EXOSC9_uc003idz.2_Missense_Mutation_p.S195N|EXOSC9_uc003ieb.2_Missense_Mutation_p.S179N|EXOSC9_uc010inp.1_RNA	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	195	ARE binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0						ATTTGTGTCAGTTTTGCCTTT	0.368		NaN											0	0	0	0.09319	0	10	77									
ADAMTS12	81792	broad.mit.edu	37	5	33576989	33576989	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr5:33576989T>A	uc003jia.1	-	19	3305	c.3142A>T	c.(3142-3144)ATC>TTC	p.I1048F	ADAMTS12_uc010iuq.1_Missense_Mutation_p.I963F	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1048	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GGGCTGCTGATTGCTGGAGTG	0.557		NaN								HNSCC(64;0.19)			0	0	0	0.124865	0	40	52									
PCDHB3	56132	broad.mit.edu	37	5	140482387	140482387	+	Missense_Mutation	SNP	G	G	T	rs113521664		TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr5:140482387G>T	uc003lio.2	+	1	2154	c.2154G>T	c.(2152-2154)AGG>AGT	p.R718S	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	718	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGGAGCAGGGCGGCCTCGG	0.667		NaN											1	0	1.54771e-57	0.139131	1.81456e-57	90	82									
PCDHB14	56122	broad.mit.edu	37	5	140604519	140604519	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr5:140604519G>A	uc003ljb.2	+	1	1442	c.1442G>A	c.(1441-1443)GGC>GAC	p.G481D	PCDHB14_uc011dal.1_Missense_Mutation_p.G328D	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	481	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGACTCAGGCACCAACGCC	0.647		NaN											0	0	0	0.139131	0	70	124									
WWC1	23286	broad.mit.edu	37	5	167835653	167835653	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr5:167835653G>A	uc003lzu.2	+	7	955	c.862G>A	c.(862-864)GGA>AGA	p.G288R	WWC1_uc003lzv.2_Missense_Mutation_p.G288R|WWC1_uc011den.1_Missense_Mutation_p.G288R|WWC1_uc003lzw.2_Missense_Mutation_p.G87R	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	288					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		AGACATCTCGGGAAGCGTGAG	0.592		NaN											0	0	0	0.160694	0	15	176									
FOXQ1	94234	broad.mit.edu	37	6	1313343	1313343	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:1313343C>A	uc003mtl.3	+	1	669	c.404C>A	c.(403-405)TCG>TAG	p.S135*		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	135	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		ATCCGCGACTCGGCGGGCGGG	0.592		NaN											1	0	1.04594e-18	0.086207	1.20549e-18	31	25									
GPX6	257202	broad.mit.edu	37	6	28478665	28478665	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:28478665C>G	uc011dlj.1	-	2	154	c.104G>C	c.(103-105)GGG>GCG	p.G35A	GPX6_uc010jrg.1_RNA	NM_182701	NP_874360	P59796	GPX6_HUMAN	glutathione peroxidase 6 precursor	35					response to oxidative stress	extracellular region	glutathione peroxidase activity			ovary(3)|pancreas(1)|skin(1)	5					Glutathione(DB00143)	GCCTGTTACCCCTTTGTTGCA	0.408		NaN											0	0	0	0.139131	0	34	31									
VPS52	6293	broad.mit.edu	37	6	33232186	33232186	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:33232186G>C	uc003odm.1	-	14	1699	c.1489C>G	c.(1489-1491)CAG>GAG	p.Q497E	VPS52_uc003odn.1_Missense_Mutation_p.Q308E	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	497					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						CCTAGGCGCTGGGGGTCAGTG	0.557		NaN											0	0	0	0.139131	0	43	51									
PHF3	23469	broad.mit.edu	37	6	64390062	64390062	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:64390062G>A	uc003pep.1	+	2	432	c.406G>A	c.(406-408)GAA>AAA	p.E136K	PHF3_uc010kaf.1_Missense_Mutation_p.E136K|PHF3_uc003pem.2_Missense_Mutation_p.E89K|PHF3_uc010kag.1_Missense_Mutation_p.E48K|PHF3_uc010kah.1_Intron|PHF3_uc003pen.2_Missense_Mutation_p.E48K|PHF3_uc011dxs.1_5'UTR|PHF3_uc003peo.2_Missense_Mutation_p.E136K	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	136					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AATGGCACAAGGTAATCCTTT	0.368		NaN											0	0	0	0.139131	0	77	73									
RIMS1	22999	broad.mit.edu	37	6	72957746	72957747	+	Nonsense_Mutation	DNP	GG	GG	CT			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:72957746_72957747GG>CT	uc003pga.2	+	12	2234_2235	c.2157_2158GG>CT	c.(2155-2160)ATGGAA>ATCTAA	p.719_720ME>I*	RIMS1_uc011dyb.1_Nonsense_Mutation_p.345_346ME>I*|RIMS1_uc003pgc.2_Nonsense_Mutation_p.345_346ME>I*|RIMS1_uc010kaq.2_Nonsense_Mutation_p.193_194ME>I*|RIMS1_uc011dyc.1_Nonsense_Mutation_p.193_194ME>I*|RIMS1_uc010kar.2_Nonsense_Mutation_p.112_113ME>I*|RIMS1_uc011dyd.1_Nonsense_Mutation_p.178_179ME>I*|RIMS1_uc003pgf.2_5'Flank|RIMS1_uc003pgg.2_5'Flank|RIMS1_uc003pgi.2_5'Flank|RIMS1_uc003pgh.2_5'Flank|RIMS1_uc003pgd.2_5'Flank|RIMS1_uc003pge.2_5'Flank|RIMS1_uc003pgb.3_Nonsense_Mutation_p.345_346ME>I*|RIMS1_uc010kas.1_Nonsense_Mutation_p.178_179ME>I*	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	719_720					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CTCAGAAGATGGAAAGGCCTTC	0.332		NaN											0	0	0	0.115264	0	22	61									
OPRM1	4988	broad.mit.edu	37	6	154412526	154412526	+	Silent	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:154412526G>A	uc003qpr.2	+	3	1320	c.1083G>A	c.(1081-1083)GAG>GAA	p.E361E	OPRM1_uc011efc.1_Silent_p.E280E|OPRM1_uc011efd.1_Silent_p.E261E|OPRM1_uc011efe.1_Silent_p.E454E|OPRM1_uc003qpn.2_Silent_p.E361E|OPRM1_uc003qpo.1_Silent_p.E361E|OPRM1_uc011eff.1_Silent_p.E361E|OPRM1_uc011efg.1_Silent_p.E361E|OPRM1_uc011efh.1_Silent_p.E361E|OPRM1_uc003qpq.1_Silent_p.E361E|OPRM1_uc003qpt.1_Silent_p.E361E|OPRM1_uc011efi.1_Silent_p.E361E|OPRM1_uc003qpp.2_RNA|OPRM1_uc003qps.2_RNA|OPRM1_uc010kjg.2_Silent_p.E261E|OPRM1_uc003qpu.2_Silent_p.E261E	NM_000914	NP_000905	P35372	OPRM_HUMAN	opioid receptor, mu 1 isoform MOR-1	361	Cytoplasmic (Potential).				behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			ovary(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	CCAACATTGAGCAACAAAACT	0.448		NaN											0	0	0	0.150653	0	3	109									
FNDC1	84624	broad.mit.edu	37	6	159655154	159655154	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:159655154C>G	uc010kjv.2	+	11	3810	c.3610C>G	c.(3610-3612)CCC>GCC	p.P1204A	FNDC1_uc010kjw.1_Missense_Mutation_p.P1089A	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1204						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCCAAAGTGGCCCTCTTCCTC	0.632		NaN											0	0	0	0.038147	0	5	15									
FNDC1	84624	broad.mit.edu	37	6	159655190	159655190	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:159655190G>A	uc010kjv.2	+	11	3846	c.3646G>A	c.(3646-3648)GAT>AAT	p.D1216N	FNDC1_uc010kjw.1_Missense_Mutation_p.D1101N	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1216						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CAAAGACGCCGATGGGAGCCT	0.637		NaN											0	0	0	0.02938	0	6	7									
IGF2R	3482	broad.mit.edu	37	6	160517637	160517637	+	Silent	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:160517637C>T	uc003qta.2	+	45	6970	c.6822C>T	c.(6820-6822)ACC>ACT	p.T2274T		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	2274	15.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		CTTGGTACACCTCAGCCGTGT	0.522		NaN											0	0	0	0.132662	0	12	74									
AMZ1	155185	broad.mit.edu	37	7	2740362	2740362	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr7:2740362C>G	uc003smr.1	+	2	638	c.277C>G	c.(277-279)CGG>GGG	p.R93G	AMZ1_uc003sms.1_Missense_Mutation_p.R93G|AMZ1_uc011jwa.1_5'Flank	NM_133463	NP_597720	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	93							metallopeptidase activity|zinc ion binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		CCGCCTGGCTCGGAAGCACAT	0.642		NaN											0	0	0	0.183431	0	25	44									
ZP3	7784	broad.mit.edu	37	7	76069569	76069569	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr7:76069569A>G	uc003ufd.3	+	6	844	c.834A>G	c.(832-834)ATA>ATG	p.I278M	ZP3_uc003ufc.3_Missense_Mutation_p.I227M|ZP3_uc003ufe.2_Missense_Mutation_p.I186M	NM_001110354	NP_001103824	P21754	ZP3_HUMAN	zona pellucida glycoprotein 3 isoform 1	278	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|blastocyst formation|egg coat formation|humoral immune response mediated by circulating immunoglobulin|intracellular protein transport|negative regulation of binding of sperm to zona pellucida|negative regulation of transcription, DNA-dependent|oocyte development|phosphatidylinositol-mediated signaling|positive regulation of acrosomal vesicle exocytosis|positive regulation of acrosome reaction|positive regulation of antral ovarian follicle growth|positive regulation of calcium ion import|positive regulation of calcium ion transport via store-operated calcium channel activity|positive regulation of humoral immune response|positive regulation of interferon-gamma production|positive regulation of interleukin-4 production|positive regulation of leukocyte migration|positive regulation of ovarian follicle development|positive regulation of phosphatidylinositol biosynthetic process|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of T cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of type IV hypersensitivity|protein kinase C signaling cascade	endoplasmic reticulum|extracellular space|Golgi apparatus|integral to membrane|multivesicular body|outer acrosomal membrane|perinuclear region of cytoplasm|plasma membrane|proteinaceous extracellular matrix	acrosin binding|manganese ion transmembrane transporter activity|receptor activity|sugar binding				0						CCTTGCAGATATACATCACCT	0.502		NaN											0	0	0	0.058154	0	7	1									
TRRAP	8295	broad.mit.edu	37	7	98592453	98592453	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr7:98592453A>G	uc003upp.2	+	66	10458	c.10249A>G	c.(10249-10251)AAA>GAA	p.K3417E	TRRAP_uc011kis.1_Missense_Mutation_p.K3388E|TRRAP_uc003upr.2_Missense_Mutation_p.K3123E	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3417					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCAGAAGCTGAAAGGCCAGTT	0.552		NaN											0	0	0	0.139131	0	80	19									
TRIM56	81844	broad.mit.edu	37	7	100730858	100730858	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr7:100730858C>T	uc003uxq.2	+	3	496	c.265C>T	c.(265-267)CGG>TGG	p.R89W	TRIM56_uc003uxr.2_Missense_Mutation_p.R89W	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	89					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					GGTGAAGGCCCGGGCCTGTGG	0.706		NaN											0	0	0	0.021553	0	5	61									
FOXP2	93986	broad.mit.edu	37	7	114270000	114270000	+	Silent	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr7:114270000G>A	uc003vhb.2	+	5	911	c.537G>A	c.(535-537)CAG>CAA	p.Q179Q	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Silent_p.Q204Q|FOXP2_uc003vha.2_Silent_p.Q87Q|FOXP2_uc011kmu.1_Silent_p.Q196Q|FOXP2_uc011kmv.1_Silent_p.Q179Q|FOXP2_uc010ljz.1_Silent_p.Q87Q|FOXP2_uc003vgt.1_RNA|FOXP2_uc003vgv.1_Silent_p.Q179Q|FOXP2_uc003vgx.2_Silent_p.Q179Q|FOXP2_uc003vhd.2_Silent_p.Q179Q|FOXP2_uc003vhc.2_Silent_p.Q204Q	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	179	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						agcaacaacagcagcagcagc	0.159		NaN											0	0	0	0.014758	0	5	18									
OR2F1	26211	broad.mit.edu	37	7	143657849	143657849	+	Silent	SNP	C	C	G			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr7:143657849C>G	uc003wds.1	+	1	830	c.786C>G	c.(784-786)CCC>CCG	p.P262P		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					ACATCCAGCCCCACTCCAGTC	0.473		NaN											0	0	0	0.150653	0	4	63									
CSMD1	64478	broad.mit.edu	37	8	2830727	2830727	+	Silent	SNP	G	G	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr8:2830727G>T	uc011kwk.1	-	57	9228	c.8838C>A	c.(8836-8838)TCC>TCA	p.S2946S	CSMD1_uc011kwj.1_Silent_p.S2275S|CSMD1_uc010lrg.2_Silent_p.S956S	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2946	Extracellular (Potential).|Sushi 22.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCATTTCACAGGAGAAGCGGA	0.552		NaN											1	0	1.23904e-05	0.014758	1.32685e-05	5	103									
KIAA1967	57805	broad.mit.edu	37	8	22475219	22475219	+	Silent	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr8:22475219G>A	uc003xch.2	+	16	2138	c.2001G>A	c.(1999-2001)AAG>AAA	p.K667K	KIAA1967_uc003xci.2_Silent_p.K667K|KIAA1967_uc003xcj.1_Silent_p.K336K	NM_199205	NP_954675	Q8N163	K1967_HUMAN	p30 DBC protein	667					apoptosis|positive regulation of apoptosis	mitochondrial matrix|nucleus	enzyme binding|enzyme inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00593)|Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		CAGGAGCAAAGCTGGAGGATT	0.532		NaN											0	0	0	0.021553	0	6	91									
ASAP1	50807	broad.mit.edu	37	8	131130435	131130435	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr8:131130435G>A	uc003yta.1	-	19	1880	c.1852C>T	c.(1852-1854)CAT>TAT	p.H618Y	ASAP1_uc003ysz.1_Missense_Mutation_p.H429Y|ASAP1_uc011liw.1_Missense_Mutation_p.H611Y	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	618	ANK 1.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						TCAACCAAATGGAGAGATGTC	0.393		NaN											0	0	0	0.150653	0	3	81									
KDM4C	23081	broad.mit.edu	37	9	7103807	7103807	+	Silent	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr9:7103807G>A	uc003zkh.2	+	18	3127	c.2547G>A	c.(2545-2547)GAG>GAA	p.E849E	KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Silent_p.E849E|KDM4C_uc011lmk.1_Silent_p.E594E|KDM4C_uc011lml.1_Silent_p.E536E	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	849	PHD-type 2.				positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						TACTGATGGAGCCTGATGACT	0.468		NaN											0	0	0	0.163468	0	28	59									
FAM75C1	441452	broad.mit.edu	37	9	90536086	90536086	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr9:90536086G>A	uc010mqi.2	+	4	1293	c.1264G>A	c.(1264-1266)GTC>ATC	p.V422I	FAM75C1_uc004apq.3_Missense_Mutation_p.V405I	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						ACCCTCTAGGGTCCAAAAATC	0.478		NaN											0	0	0	0.064281	0	26	151									
IKBKAP	8518	broad.mit.edu	37	9	111665223	111665223	+	Splice_Site	SNP	C	C	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr9:111665223C>A	uc004bdm.3	-	16	2271	c.1751_splice	c.e16-1	p.E584_splice	IKBKAP_uc004bdl.2_Splice_Site_p.E235_splice|IKBKAP_uc011lwc.1_Splice_Site_p.E470_splice|IKBKAP_uc010mtq.2_Splice_Site_p.E235_splice	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene						immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						GAAGGTGACTCTGCAAGATTC	0.413		NaN											1	0	1.50039e-11	0.062417	1.70044e-11	20	48									
SEC16A	9919	broad.mit.edu	37	9	139369743	139369743	+	Silent	SNP	C	C	T			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr9:139369743C>T	uc004chx.2	-	3	2634	c.2325G>A	c.(2323-2325)TCG>TCA	p.S775S	SEC16A_uc004chv.3_Silent_p.S402S|SEC16A_uc004chw.2_Silent_p.S775S|SEC16A_uc010nbn.2_Silent_p.S775S|SEC16A_uc010nbo.1_Silent_p.S775S	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	597					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CCGGGGCCGCCGAGCTTGGGT	0.607		NaN											0	0	0	0.047766	0	7	56									
PNPLA4	8228	broad.mit.edu	37	X	7870171	7870171	+	Silent	SNP	G	G	A	rs150755827		TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chrX:7870171G>A	uc011mhq.1	-	6	651	c.489C>T	c.(487-489)GAC>GAT	p.D163D	PNPLA4_uc011mhr.1_Silent_p.D163D|PNPLA4_uc011mhs.1_Silent_p.D76D	NM_004650	NP_004641	P41247	PLPL4_HUMAN	patatin-like phospholipase domain containing 4	163	Patatin.				lipid catabolic process		triglyceride lipase activity				0		Colorectal(8;0.0329)|Medulloblastoma(8;0.232)				TGAGGCCTCCGTCCACCCACT	0.542		NaN											0	0	0	0.116897	0	26	4									
ZFX	7543	broad.mit.edu	37	X	24225885	24225885	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chrX:24225885C>A	uc004dbf.2	+	6	1111	c.853C>A	c.(853-855)CTT>ATT	p.L285I	ZFX_uc004dbd.1_Missense_Mutation_p.L285I|ZFX_uc010nfx.1_Missense_Mutation_p.L56I|ZFX_uc004dbe.2_Missense_Mutation_p.L285I|ZFX_uc011mjv.1_Missense_Mutation_p.L324I|ZFX_uc010nfy.1_Intron|ZFX_uc010nfz.2_5'UTR	NM_003410	NP_003401	P17010	ZFX_HUMAN	zinc finger protein, X-linked	285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(2)	2						AGTTGAACTGCTTGATCAGAA	0.403		NaN											1	0	7.03913e-09	0.09319	7.7831e-09	11	122									
FAM47C	442444	broad.mit.edu	37	X	37027200	37027200	+	Silent	SNP	A	A	C			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chrX:37027200A>C	uc004ddl.1	+	1	731	c.717A>C	c.(715-717)CCA>CCC	p.P239P		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	239										ovary(3)	3						TGGAGCCTCCAGAGACTGGAG	0.637		NaN											0	0	0	0.115264	0	3	53									
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chrX:37028425A>G	uc004ddl.1	+	1	1956	c.1942A>G	c.(1942-1944)AAT>GAT	p.N648D		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	648										ovary(3)	3						GGAGCCTCCCAATACTGGAGT	0.642		NaN											0	0	0	0.014758	0	4	78									
ZCCHC5	203430	broad.mit.edu	37	X	77912689	77912689	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chrX:77912689T>A	uc004edc.1	-	2	1525	c.1229A>T	c.(1228-1230)GAT>GTT	p.D410V		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	410							nucleic acid binding|zinc ion binding			ovary(1)	1						CTCGGGTCCATCTCCCTCTGC	0.537		NaN											0	0	0	0.139131	0	53	9									
NXF3	56000	broad.mit.edu	37	X	102334726	102334726	+	Silent	SNP	G	G	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chrX:102334726G>A	uc004eju.2	-	13	1196	c.1125C>T	c.(1123-1125)TCC>TCT	p.S375S	NXF3_uc010noi.1_Silent_p.S225S	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	375	NTF2.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						GAATGCTCAGGGAGAAGCAGG	0.547		NaN											0	0	0	0.115264	0	3	70									
TEX13A	56157	broad.mit.edu	37	X	104463696	104463696	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chrX:104463696C>A	uc004ema.2	-	5	1292	c.1180G>T	c.(1180-1182)GAT>TAT	p.D394Y	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_3'UTR	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	394	RanBP2-type.					intracellular	zinc ion binding			ovary(2)	2						AAGCAAGTATCCCTCCGTGAA	0.488		NaN											1	0	3.6533e-62	0.139131	4.32043e-62	121	19									
PBXIP1	57326	broad.mit.edu	37	1	154917508	154917510	+	In_Frame_Del	DEL	GGT	GGT	-	rs143592003		TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:154917508_154917510delGGT	uc001ffr.2	-	11	2245_2247	c.2186_2188delACC	c.(2185-2190)CACCGG>CGG	p.H729del	PBXIP1_uc001ffs.2_In_Frame_Del_p.H700del|PBXIP1_uc010pep.1_In_Frame_Del_p.H574del	NM_020524	NP_065385	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein	729	His-rich.				cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TGTCAGCCCCGGTGGTGGTGGTG	0.64		NaN											NaN	NaN	NaN	NaN	NaN	7	214	---	---							
MLEC	9761	broad.mit.edu	37	12	121125148	121125150	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:121125148_121125150delCTG	uc001tyy.1	+	1	200_202	c.49_51delCTG	c.(49-51)CTGdel	p.L22del		NM_014730	NP_055545	Q14165	MLEC_HUMAN	malectin precursor	22					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			ovary(1)	1						gctcctgcgactgctgctgctgc	0.517		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
SLC25A30	253512	broad.mit.edu	37	13	45985521	45985522	+	Frame_Shift_Ins	INS	-	-	C			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr13:45985521_45985522insC	uc001vag.2	-	2	176_177	c.39_40insG	c.(37-42)GGGCTGfs	p.G13fs	SLC25A30_uc010tfs.1_5'UTR|SLC25A30_uc001vah.2_5'UTR|SLC25A30_uc010tft.1_Intron	NM_001010875	NP_001010875	Q5SVS4	KMCP1_HUMAN	solute carrier family 25, member 30	13_14	Solcar 1.|Helical; Name=1; (Potential).				mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding			breast(1)	1		Lung NSC(96;0.00227)|Prostate(109;0.00578)|Breast(56;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.95e-05)		ATGGAGGCCAGCCCCCCGTACA	0.495		NaN											NaN	NaN	NaN	NaN	NaN	59	24	---	---							
CHD3	1107	broad.mit.edu	37	17	7788146	7788148	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:7788146_7788148delGAG	uc002gjd.2	+	1	24_26	c.22_24delGAG	c.(22-24)GAGdel	p.E14del		NM_001005271	NP_001005271	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				TCTGAGggacgaggaggaggagg	0.094		NaN											NaN	NaN	NaN	NaN	NaN	3	4	---	---							
CRLF3	51379	broad.mit.edu	37	17	29112973	29112973	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:29112973delG	uc002hfr.3	-	7	1145	c.1036delC	c.(1036-1038)CTGfs	p.L346fs	CRLF3_uc010wbr.1_Frame_Shift_Del_p.L230fs	NM_015986	NP_057070	Q8IUI8	CRLF3_HUMAN	cytokine receptor-like factor 3	346					negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of cell cycle arrest|positive regulation of JAK-STAT cascade|positive regulation of transcription from RNA polymerase II promoter	cytoplasm					0		all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				TCCCGCTGCAGAGAGTCATAT	0.368		NaN											NaN	NaN	NaN	NaN	NaN	31	283	---	---							
USP25	29761	broad.mit.edu	37	21	17250653	17250653	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr21:17250653delG	uc002yjy.1	+	24	3244	c.3027delG	c.(3025-3027)TTGfs	p.L1009fs	USP25_uc011aby.1_Frame_Shift_Del_p.L1079fs|USP25_uc002yjz.1_Frame_Shift_Del_p.L1041fs|USP25_uc010gla.1_Frame_Shift_Del_p.L404fs	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	1009					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		CAGATTTTTTGCCAAAACTGC	0.363		NaN											NaN	NaN	NaN	NaN	NaN	57	47	---	---							
WRNIP1	56897	broad.mit.edu	37	6	2766344	2766346	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:2766344_2766346delAGG	uc003mtz.2	+	1	679_681	c.488_490delAGG	c.(487-492)CAGGAG>CAG	p.E167del	WRNIP1_uc003mua.2_In_Frame_Del_p.E167del	NM_020135	NP_064520	Q96S55	WRIP1_HUMAN	Werner helicase interacting protein isoform 1	167					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA-dependent DNA replication initiation	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|DNA binding|metal ion binding|protein binding			ovary(1)|pancreas(1)	2	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				gcggaggcgcaggaggaggagga	0.374		NaN											NaN	NaN	NaN	NaN	NaN	3	4	---	---							
KRBA1	84626	broad.mit.edu	37	7	149427255	149427255	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr7:149427255delC	uc003wfz.2	+	15	2228	c.1829delC	c.(1828-1830)TCCfs	p.S610fs	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Frame_Shift_Del_p.S217fs	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	610	Pro-rich.									ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCCAAGCCCTCCCCGCTGCAC	0.567		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
NUDCD1	84955	broad.mit.edu	37	8	110293311	110293312	+	Frame_Shift_Del	DEL	TG	TG	-	rs143668430		TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr8:110293311_110293312delTG	uc003ynb.3	-	6	1024_1025	c.913_914delCA	c.(913-915)CAGfs	p.Q305fs	NUDCD1_uc003yna.2_Frame_Shift_Del_p.Q276fs|NUDCD1_uc010mcl.2_Frame_Shift_Del_p.Q218fs|NUDCD1_uc010mcm.1_Frame_Shift_Del_p.Q218fs	NM_032869	NP_116258	Q96RS6	NUDC1_HUMAN	NudC domain containing 1 isoform 1	305	CS.									ovary(1)|breast(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;1.56e-12)			AGGCAAAAACTGTATTTGAATG	0.371		NaN											NaN	NaN	NaN	NaN	NaN	82	10	---	---							
