Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
CDK11A	728642	broad.mit.edu	37	1	1634992	1634992	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:1634992G>A	uc009vks.2	-	18	2091	c.1983C>T	c.(1981-1983)TTC>TTT	p.F661F	CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agv.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc001ahj.3_Silent_p.F168F|CDK11A_uc009vkp.2_Silent_p.F278F|CDK11A_uc009vkq.2_RNA|CDK11A_uc009vkr.2_Silent_p.F651F	NM_024011	NP_076916	Q9UQ88	CD11A_HUMAN	cell division cycle 2-like 2 isoform 1	664					apoptosis|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			stomach(1)	1						GGTGCTCGCTGAAGGTCATCT	0.587		NaN											0	0	0	0.000602	0	4	15									
GNB1	2782	broad.mit.edu	37	1	1756890	1756890	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:1756890C>A	uc001aif.2	-	3	335	c.3G>T	c.(1-3)ATG>ATT	p.M1I	GNB1_uc009vky.2_5'UTR	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	1					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		CAAGCTCACTCATCTTCCGAT	0.398		NaN											1	0	2.4537e-52	0.01441	2.86817e-52	129	128									
SLC45A1	50651	broad.mit.edu	37	1	8403885	8403885	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:8403885G>T	uc001apb.2	+	8	2059	c.2059G>T	c.(2059-2061)GCT>TCT	p.A687S	SLC45A1_uc001apc.2_Missense_Mutation_p.A385S	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	687	Helical; (Potential).				carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GTACTTCCTGGCTCAGATTCT	0.642		NaN											1	0	3.51602e-12	0.008871	3.81361e-12	17	57									
UBR4	23352	broad.mit.edu	37	1	19487579	19487579	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:19487579C>T	uc001bbi.2	-	38	5242	c.5238G>A	c.(5236-5238)CAG>CAA	p.Q1746Q	UBR4_uc001bbm.1_Silent_p.Q957Q	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1746					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TGGGTTCACTCTGAAATGCCG	0.517		NaN											0	0	0	0.00308	0	8	23									
LDLRAP1	26119	broad.mit.edu	37	1	25893369	25893369	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:25893369C>T	uc001bkl.3	+	9	927	c.813C>T	c.(811-813)GTC>GTT	p.V271V	LDLRAP1_uc009vrw.2_RNA|LDLRAP1_uc009vrx.2_Silent_p.V101V	NM_015627	NP_056442	Q5SW96	ARH_HUMAN	low density lipoprotein receptor adaptor protein	271	AP-2 complex binding.				amyloid precursor protein metabolic process|cholesterol homeostasis|cholesterol metabolic process|positive regulation of receptor-mediated endocytosis|receptor internalization|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|regulation of establishment of protein localization in plasma membrane|regulation of protein binding	basal plasma membrane|cytosol|early endosome|internal side of plasma membrane|neurofilament|recycling endosome	beta-amyloid binding|clathrin binding|low-density lipoprotein particle receptor binding|phosphatidylinositol-4,5-bisphosphate binding|phosphotyrosine binding|protein binding, bridging|protein complex binding|receptor signaling complex scaffold activity|signaling adaptor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.63e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|GBM - Glioblastoma multiforme(114;0.00914)|READ - Rectum adenocarcinoma(331;0.0649)		ACCCTCAGGTCCTGGACACTG	0.657		NaN											0	0	0	0.000602	0	5	10									
POU3F1	5453	broad.mit.edu	37	1	38511353	38511353	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:38511353C>T	uc001ccp.1	-	1	1098	c.1063G>A	c.(1063-1065)GAG>AAG	p.E355K		NM_002699	NP_002690	Q03052	PO3F1_HUMAN	POU domain, class 3, transcription factor 1	355	Homeobox.				positive regulation of transcription, DNA-dependent		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AAGTGGCTCTCGAGCGCGCCT	0.662		NaN											0	0	0	0.001168	0	6	10									
HPCAL4	51440	broad.mit.edu	37	1	40150121	40150121	+	Missense_Mutation	SNP	T	T	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:40150121T>A	uc001cdr.2	-	2	275	c.155A>T	c.(154-156)TAC>TTC	p.Y52F	HPCAL4_uc010oix.1_Missense_Mutation_p.Y52F	NM_016257	NP_057341	Q9UM19	HPCL4_HUMAN	hippocalcin-like protein 4	52	EF-hand 1.				central nervous system development	intracellular	calcium ion binding			central_nervous_system(1)	1	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CACCTTGATGTAGAGCTGCTG	0.632		NaN											0	0	0	0.006122	0	14	14									
POMGNT1	55624	broad.mit.edu	37	1	46655654	46655654	+	Missense_Mutation	SNP	C	C	T	rs150351855		TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:46655654C>T	uc001cpe.2	-	20	1821	c.1657G>A	c.(1657-1659)GAG>AAG	p.E553K	POMGNT1_uc010olx.1_Missense_Mutation_p.E531K|POMGNT1_uc010oly.1_RNA|POMGNT1_uc010olz.1_Missense_Mutation_p.E410K|POMGNT1_uc001cpg.2_Missense_Mutation_p.E553K|POMGNT1_uc001cpf.2_Missense_Mutation_p.E220K	NM_017739	NP_060209	Q8WZA1	PMGT1_HUMAN	O-linked mannose	553	Lumenal (Potential).				protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TCCAGAACCTCAGCCTCACTG	0.443		NaN											0	0	0	0.009096	0	3	16									
LRRC41	10489	broad.mit.edu	37	1	46744864	46744864	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:46744864G>C	uc001cpn.2	-	9	2253	c.2209C>G	c.(2209-2211)CTG>GTG	p.L737V	LRRC41_uc010omb.1_3'UTR	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	737	LRR 7.									ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					CTGATGTCCAGCTGACAGAGA	0.532		NaN											0	0	0	0.007291	0	24	17									
FAF1	11124	broad.mit.edu	37	1	50941244	50941244	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:50941244C>T	uc009vyx.1	-	19	1824	c.1761G>A	c.(1759-1761)GAG>GAA	p.E587E	FAF1_uc009vyw.1_RNA|FAF1_uc001cse.1_Silent_p.E587E|FAF1_uc010onc.1_Silent_p.E345E	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1	587	UBX.				apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		GGAAACGCCGCTCCAAGAACT	0.522		NaN											0	0	0	0.009096	0	4	26									
CDC7	8317	broad.mit.edu	37	1	91967346	91967346	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:91967346G>A	uc001doe.2	+	2	238	c.73G>A	c.(73-75)GAA>AAA	p.E25K	CDC7_uc001dof.2_Missense_Mutation_p.E25K|CDC7_uc010osw.1_Missense_Mutation_p.E25K|CDC7_uc009wdc.2_Missense_Mutation_p.E25K	NM_003503	NP_003494	O00311	CDC7_HUMAN	cell division cycle 7	25					cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	5		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		GTTTCAGGCTGAAGGCTCTTT	0.413		NaN											0	0	0	0.003954	0	24	90									
GLMN	11146	broad.mit.edu	37	1	92757089	92757089	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:92757089G>A	uc001dor.2	-	4	286	c.171C>T	c.(169-171)ATC>ATT	p.I57I	GLMN_uc009wdg.2_RNA|GLMN_uc001dos.2_Silent_p.I57I	NM_053274	NP_444504	Q92990	GLMN_HUMAN	glomulin	57					muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			skin(1)	1		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)		TATTCTTGATGATGACCTGTA	0.373		NaN							Multiple_Glomus_Tumors_(of_the_Skin)_Familial				0	0	0	0.010729	0	9	25									
CCDC18	343099	broad.mit.edu	37	1	93646208	93646208	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:93646208C>T	uc001dpq.2	+	1	289	c.121C>T	c.(121-123)CGG>TGG	p.R41W	TMED5_uc001dpn.2_5'UTR|TMED5_uc001dpo.2_5'UTR|TMED5_uc001dpp.2_RNA	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	Error:Variant_position_missing_in_Q5T9S5_after_alignment										ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		CCCGCGCCTTCGGCGGCGCCT	0.721		NaN											0	0	0	0.007413	0	20	9									
KCNA2	3737	broad.mit.edu	37	1	111147122	111147122	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:111147122C>A	uc001dzu.2	-	2	779	c.283G>T	c.(283-285)GGG>TGG	p.G95W	KCNA2_uc009wfv.1_Missense_Mutation_p.G95W|KCNA2_uc009wfw.2_Missense_Mutation_p.G95W	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	95						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		AATCGGCCCCCTGACTGGTAG	0.473		NaN											1	0	0.000978159	0.010729	0.00101028	12	48									
SIKE1	80143	broad.mit.edu	37	1	115318966	115318966	+	Splice_Site	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:115318966C>T	uc001efo.3	-	4	602	c.522_splice	c.e4+1	p.E174_splice	SIKE1_uc001efp.3_Splice_Site_p.E178_splice	NM_025073	NP_079349	Q9BRV8	SIKE1_HUMAN	suppressor of IKK epsilon isoform 2							cytosol	protein binding				0						TACAATCTTACCTCTAATTGG	0.373		NaN											0	0	0	0.00499	0	17	62									
SPAG17	200162	broad.mit.edu	37	1	118640299	118640299	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:118640299C>T	uc001ehk.2	-	7	1073	c.1005G>A	c.(1003-1005)GAG>GAA	p.E335E		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	335						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TAACCATCATCTCACCATCTG	0.348		NaN											0	0	0	0.004482	0	6	18									
SETDB1	9869	broad.mit.edu	37	1	150923028	150923028	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:150923028C>T	uc001evu.2	+	13	1865	c.1675C>T	c.(1675-1677)CCA>TCA	p.P559S	SETDB1_uc009wmf.2_Missense_Mutation_p.P560S|SETDB1_uc001evv.2_Missense_Mutation_p.P559S|SETDB1_uc009wmg.1_Missense_Mutation_p.P559S	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	559					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGAGCGGGCCCCAGCAGAGCC	0.587		NaN											0	0	0	0.00632	0	29	179									
SHE	126669	broad.mit.edu	37	1	154459062	154459062	+	Silent	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:154459062G>T	uc001ffb.2	-	4	1209	c.1122C>A	c.(1120-1122)GCC>GCA	p.A374A	SHE_uc001ffc.2_RNA	NM_001010846	NP_001010846	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	374										breast(3)|ovary(2)|central_nervous_system(1)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGTCCGAGAGGGCTGGCTTCA	0.597		NaN											1	0	1.32181e-22	0.007291	1.4995e-22	29	106									
DCST1	149095	broad.mit.edu	37	1	155013956	155013956	+	Silent	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:155013956G>T	uc001fgn.1	+	7	711	c.615G>T	c.(613-615)ACG>ACT	p.T205T	DCST1_uc010per.1_Silent_p.T230T|DCST1_uc010pes.1_Silent_p.T180T	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	205	Extracellular (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			ATAGTGAGACGGGCTACACGC	0.587		NaN											1	0	6.42651e-13	0.010729	6.99237e-13	12	87									
DCST1	149095	broad.mit.edu	37	1	155023327	155023327	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:155023327A>G	uc001fgn.1	+	17	2200	c.2104A>G	c.(2104-2106)ACT>GCT	p.T702A	DCST1_uc010pes.1_Missense_Mutation_p.T677A|uc001fgo.2_RNA|ADAM15_uc001fgq.1_5'Flank|ADAM15_uc009wpc.1_5'Flank|ADAM15_uc010pet.1_5'Flank|ADAM15_uc010peu.1_5'Flank|ADAM15_uc001fgt.1_5'Flank|ADAM15_uc010pev.1_5'Flank|ADAM15_uc001fgs.1_5'Flank|ADAM15_uc001fgr.1_5'Flank|ADAM15_uc001fgu.1_5'Flank|ADAM15_uc001fgw.1_5'Flank|ADAM15_uc001fgv.1_5'Flank|ADAM15_uc001fgx.1_5'Flank|ADAM15_uc001fgz.1_5'Flank|ADAM15_uc001fgy.1_5'Flank|ADAM15_uc001fha.1_5'Flank	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	702	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CAACGACGACACTGCCTACGC	0.637		NaN									OREG0013846	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00278	0	22	12									
SCAMP3	10067	broad.mit.edu	37	1	155226174	155226174	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:155226174G>A	uc001fjs.2	-	9	1187	c.934C>T	c.(934-936)CAG>TAG	p.Q312*	RAG1AP1_uc010pey.1_Intron|FAM189B_uc001fjm.2_5'Flank|FAM189B_uc001fjn.2_5'Flank|FAM189B_uc001fjo.2_5'Flank|FAM189B_uc001fjp.2_5'Flank|FAM189B_uc001fjq.1_5'Flank|SCAMP3_uc001fjr.2_Nonsense_Mutation_p.Q159*|SCAMP3_uc001fju.2_Nonsense_Mutation_p.Q298*|SCAMP3_uc001fjv.2_3'UTR|SCAMP3_uc001fjt.2_Nonsense_Mutation_p.Q286*	NM_005698	NP_005689	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3 isoform 1	312	Cytoplasmic (Potential).				post-Golgi vesicle-mediated transport|protein transport	integral to membrane				ovary(3)	3	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGGGCCTTCTGAAAGCTGGCA	0.582		NaN											0	0	0	0.01441	0	46	236									
GON4L	54856	broad.mit.edu	37	1	155736062	155736062	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:155736062A>G	uc001flz.2	-	21	3299	c.3202T>C	c.(3202-3204)TCT>CCT	p.S1068P	GON4L_uc009wrg.1_RNA|GON4L_uc001fly.1_Missense_Mutation_p.S1068P|GON4L_uc009wrh.1_Missense_Mutation_p.S1068P|GON4L_uc001fma.1_Missense_Mutation_p.S1068P|GON4L_uc001fmb.3_Missense_Mutation_p.S264P|GON4L_uc001fmc.2_Missense_Mutation_p.S1068P|GON4L_uc001fmd.3_Missense_Mutation_p.S1068P|GON4L_uc009wri.2_Missense_Mutation_p.S654P	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	1068					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GCTGCAGGAGACTCAAAACTC	0.567		NaN											0	0	0	0.01441	0	52	13									
CD84	8832	broad.mit.edu	37	1	160520800	160520800	+	Nonsense_Mutation	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:160520800G>T	uc001fwh.3	-	6	861	c.837C>A	c.(835-837)TAC>TAA	p.Y279*	CD84_uc001fwf.3_Nonsense_Mutation_p.Y262*|CD84_uc001fwg.3_Nonsense_Mutation_p.Y273*|CD84_uc009wtn.2_Intron|CD84_uc001fwi.3_Nonsense_Mutation_p.Y148*	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	279	Cytoplasmic (Potential).|ITSM motif 1.			Y->F: Reduced tyrosine phosphorylation, reduced binding of SH2D1B and loss of binding of SH2D1A.	blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TGATATATGTGTATATGGTTT	0.378		NaN											1	0	2.26627e-22	0.007835	2.55417e-22	40	79									
LMX1A	4009	broad.mit.edu	37	1	165173230	165173230	+	Missense_Mutation	SNP	T	T	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:165173230T>A	uc001gcy.1	-	8	1257	c.1036A>T	c.(1036-1038)AGT>TGT	p.S346C	LMX1A_uc001gcz.1_Missense_Mutation_p.S346C|LMX1A_uc001gcw.1_Missense_Mutation_p.S64C|LMX1A_uc001gcx.1_Missense_Mutation_p.S97C	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	346						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					CCCAGGTTACTGAGGGAGGTG	0.507		NaN											0	0	0	0.00308	0	8	86									
SCYL3	57147	broad.mit.edu	37	1	169857941	169857941	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:169857941C>G	uc001ggs.2	-	2	239	c.41G>C	c.(40-42)AGA>ACA	p.R14T	SCYL3_uc001ggt.2_Missense_Mutation_p.R14T|SCYL3_uc001ggu.2_RNA	NM_181093	NP_851607	Q8IZE3	PACE1_HUMAN	SCY1-like 3 isoform 2	14	Protein kinase.				cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			ovary(1)|skin(1)	2	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGGTGGTTCTCTCAGTGTATA	0.423		NaN											0	0	0	0.008291	0	10	72									
LHX4	89884	broad.mit.edu	37	1	180217472	180217472	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:180217472G>A	uc001goe.1	+	2	352	c.129G>A	c.(127-129)CTG>CTA	p.L43L		NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	43	LIM zinc-binding 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						AGTTCATCCTGAAGGTCCTGG	0.592		NaN											0	0	0	0.00308	0	8	49									
ASPM	259266	broad.mit.edu	37	1	197112811	197112811	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:197112811G>A	uc001gtu.2	-	3	828	c.571C>T	c.(571-573)CCA>TCA	p.P191S	ASPM_uc001gtv.2_Missense_Mutation_p.P191S|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	191					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GCTTGTAGTGGGCTCCTAACT	0.353		NaN											0	0	0	0.01441	0	85	14									
PIK3C2B	5287	broad.mit.edu	37	1	204412707	204412707	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:204412707G>A	uc001haw.2	-	20	3365	c.2886C>T	c.(2884-2886)CTC>CTT	p.L962L	PIK3C2B_uc010pqv.1_Silent_p.L934L	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	962					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GAGAGTCCTTGAGGCCGTCCT	0.587		NaN											0	0	0	0.01441	0	151	24									
LYST	1130	broad.mit.edu	37	1	235973787	235973787	+	Missense_Mutation	SNP	T	T	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:235973787T>A	uc001hxj.2	-	5	506	c.331A>T	c.(331-333)AAC>TAC	p.N111Y	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.N111Y	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	111					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GAACTTGAGTTCTTTTCTTTG	0.348		NaN							Chediak-Higashi_syndrome				0	0	0	0.012213	0	33	9									
TRIM58	25893	broad.mit.edu	37	1	248028105	248028105	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:248028105G>A	uc001ido.2	+	3	663	c.615G>A	c.(613-615)GAG>GAA	p.E205E		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	205	Potential.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCGGCTGGAGGCGGAGGAGC	0.622		NaN											0	0	0	0.010771	0	42	8									
RSU1	6251	broad.mit.edu	37	10	16824066	16824066	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:16824066T>C	uc001iok.2	-	2	429	c.127A>G	c.(127-129)ACA>GCA	p.T43A	RSU1_uc001iol.2_Missense_Mutation_p.T43A|RSU1_uc001iom.2_5'UTR|RSU1_uc001ion.2_Missense_Mutation_p.T43A	NM_152724	NP_689937	Q15404	RSU1_HUMAN	ras suppressor protein 1 isoform 2	43	LRR 1.				cell junction assembly|signal transduction	cytosol	protein binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(1;7.54e-08)		ACCAGTTGTGTGATATGGGAT	0.373		NaN											0	0	0	0.004482	0	8	35									
ANKRD30A	91074	broad.mit.edu	37	10	37486374	37486374	+	Silent	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:37486374C>A	uc001iza.1	+	29	2613	c.2514C>A	c.(2512-2514)GCC>GCA	p.A838A		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	894						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CAAATAAAGCCTTGGAATTGA	0.318		NaN											1	0	6.97489e-18	0.004878	7.75984e-18	28	34									
CHAT	1103	broad.mit.edu	37	10	50872873	50872873	+	Silent	SNP	T	T	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:50872873T>C	uc001jhz.2	+	15	2181	c.2028T>C	c.(2026-2028)AAT>AAC	p.N676N	CHAT_uc001jhv.1_Silent_p.N558N|CHAT_uc001jhx.1_Silent_p.N558N|CHAT_uc001jhy.1_Silent_p.N558N|CHAT_uc001jia.2_Silent_p.N558N|CHAT_uc010qgs.1_Intron	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	676					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	TGGTCCCAAATGGGTATGGTG	0.537		NaN											0	0	0	0.01441	0	48	137									
KIAA0913	23053	broad.mit.edu	37	10	75545836	75545836	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:75545836G>A	uc009xrl.2	+	1	232	c.200G>A	c.(199-201)AGA>AAA	p.R67K	KIAA0913_uc009xrk.1_3'UTR|KIAA0913_uc001jve.2_Missense_Mutation_p.R67K|KIAA0913_uc001jvf.2_Missense_Mutation_p.R67K|uc009xrm.1_5'Flank	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	67							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					GGCGGTACCAGAATGCGAGGT	0.692		NaN											0	0	0	0.004672	0	3	10									
CEP55	55165	broad.mit.edu	37	10	95287764	95287764	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:95287764G>A	uc009xug.2	+	9	1431	c.1249G>A	c.(1249-1251)GAA>AAA	p.E417K	CEP55_uc001kiq.3_Missense_Mutation_p.E417K	NM_001127182	NP_001120654	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	417	Required for localization to the interphase centrosome and to the midbody during cytokinesis.				cell division|mitosis	centriole|cleavage furrow|midbody					0		Colorectal(252;0.207)				AGGAGAGACTGAAAACAGAGA	0.418		NaN											0	0	0	0.001855	0	12	26									
ZNF518A	9849	broad.mit.edu	37	10	97920088	97920088	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:97920088C>T	uc001klp.2	+	6	4866	c.4009C>T	c.(4009-4011)CTT>TTT	p.L1337F	ZNF518A_uc001klo.1_Missense_Mutation_p.L807F|ZNF518A_uc001klq.2_Missense_Mutation_p.L1337F|ZNF518A_uc001klr.2_Missense_Mutation_p.L1337F	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	1337					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		TTCTAAACAGCTTGTGAAATG	0.378		NaN											0	0	0	0.000602	0	5	15									
SLIT1	6585	broad.mit.edu	37	10	98794286	98794286	+	Missense_Mutation	SNP	T	T	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:98794286T>G	uc001kmw.2	-	23	2632	c.2380A>C	c.(2380-2382)AAC>CAC	p.N794H	SLIT1_uc009xvh.1_Intron	NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	794	LRR 18.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		CTGATCTTGTTGTTGCTCAGG	0.562		NaN											0	0	0	0.008361	0	29	37									
CHUK	1147	broad.mit.edu	37	10	101977825	101977825	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:101977825C>G	uc001kqp.2	-	9	915	c.860G>C	c.(859-861)AGA>ACA	p.R287T		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	287	Protein kinase.				I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		AGGTCCTCCTCTCTGCTGAGG	0.373		NaN											0	0	0	0.010729	0	12	7									
NFKB2	4791	broad.mit.edu	37	10	104157318	104157318	+	Silent	SNP	A	A	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:104157318A>G	uc001kvb.2	+	8	802	c.537A>G	c.(535-537)AAA>AAG	p.K179K	NFKB2_uc001kva.2_Silent_p.K179K|NFKB2_uc010qqk.1_Silent_p.K179K|NFKB2_uc001kvd.2_Silent_p.K179K|NFKB2_uc009xxc.2_Silent_p.K179K	NM_001077494	NP_001070962	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene	179	RHD.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(3)	3		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		AAGAGGCCAAAGAACTGAAGA	0.592		NaN	T	IGH@	B-NHL								0	0	0	0.004878	0	38	65									
ABLIM1	3983	broad.mit.edu	37	10	116247730	116247730	+	Missense_Mutation	SNP	T	T	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:116247730T>A	uc010qsg.1	-	8	1127	c.1028A>T	c.(1027-1029)GAG>GTG	p.E343V	ABLIM1_uc010qsh.1_Missense_Mutation_p.E283V|ABLIM1_uc010qsi.1_Missense_Mutation_p.E283V|ABLIM1_uc010qsk.1_Missense_Mutation_p.E267V|ABLIM1_uc009xyp.2_Missense_Mutation_p.E277V|ABLIM1_uc010qsf.1_Missense_Mutation_p.E27V|ABLIM1_uc009xyn.2_Missense_Mutation_p.E20V|ABLIM1_uc010qsj.1_Missense_Mutation_p.E20V|ABLIM1_uc009xyo.2_Missense_Mutation_p.E191V	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a	343	LIM zinc-binding 4.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		CAGCTTTTCCTCGGTCTTCGT	0.478		NaN											0	0	0	0.00333	0	23	60									
PNLIP	5406	broad.mit.edu	37	10	118305637	118305637	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:118305637G>A	uc001lcm.2	+	2	76	c.33G>A	c.(31-33)CTG>CTA	p.L11L		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	11					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	CACTGCTGCTGGGAGCAGTAG	0.433		NaN											0	0	0	0.001855	0	13	25									
WDR11	55717	broad.mit.edu	37	10	122624668	122624668	+	Missense_Mutation	SNP	G	G	C	rs145467317		TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:122624668G>C	uc010qtf.1	+	6	1061	c.823G>C	c.(823-825)GTG>CTG	p.V275L	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	275						integral to membrane					0						TGACCTTGAGGTGAATCAGAC	0.378		NaN											0	0	0	0.006122	0	19	28									
DMBT1	1755	broad.mit.edu	37	10	124399605	124399605	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:124399605C>T	uc001lgk.1	+	52	6711	c.6605C>T	c.(6604-6606)TCA>TTA	p.S2202L	DMBT1_uc001lgl.1_Missense_Mutation_p.S2192L|DMBT1_uc001lgm.1_Missense_Mutation_p.S1574L|DMBT1_uc009xzz.1_Missense_Mutation_p.S2201L|DMBT1_uc010qtx.1_Missense_Mutation_p.S922L|DMBT1_uc009yab.1_Missense_Mutation_p.S905L|DMBT1_uc009yac.1_Missense_Mutation_p.S496L	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2202	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GCAGCTGTCTCAGGTGGCATC	0.522		NaN											0	0	0	0.008361	0	31	30									
PKP3	11187	broad.mit.edu	37	11	404268	404268	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:404268C>T	uc001lpc.2	+	12	2379	c.2303C>T	c.(2302-2304)TCC>TTC	p.S768F		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	768					cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CGGGCAGCATCCAGCCTCCTG	0.662		NaN											0	0	0	0.008361	0	27	55									
TRAF6	7189	broad.mit.edu	37	11	36523047	36523047	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:36523047C>T	uc001mwr.1	-	3	359	c.19G>A	c.(19-21)GAA>AAA	p.E7K	TRAF6_uc001mws.1_Missense_Mutation_p.E7K	NM_145803	NP_665802	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6	7	Interaction with TAX1BP1.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				CAGCTGTTTTCACAGTTTAGC	0.448		NaN											0	0	0	0.010729	0	11	17									
OR4A16	81327	broad.mit.edu	37	11	55110736	55110736	+	Missense_Mutation	SNP	T	T	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:55110736T>A	uc010rie.1	+	1	60	c.60T>A	c.(58-60)GAT>GAA	p.D20E		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						AAGATCCTGATGTGAAAAAAA	0.413		NaN											0	0	0	0.001168	0	6	9									
OR5L2	26338	broad.mit.edu	37	11	55595538	55595538	+	Missense_Mutation	SNP	A	A	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:55595538A>T	uc001nhy.1	+	1	844	c.844A>T	c.(844-846)ATT>TTT	p.I282F		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				CACAGTTGTGATTCCCATGCT	0.463		NaN								HNSCC(27;0.073)			0	0	0	0.006214	0	8	9									
OR8H1	219469	broad.mit.edu	37	11	56058390	56058390	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:56058390C>T	uc010rje.1	-	1	149	c.149G>A	c.(148-150)CGC>CAC	p.R50H		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					GAGGTCCAGGCGGATTATCAA	0.423		NaN											0	0	0	0.01441	0	80	115									
UBE2L6	9246	broad.mit.edu	37	11	57319864	57319864	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:57319864G>A	uc001nkn.1	-	4	525	c.429C>T	c.(427-429)TTC>TTT	p.F143F	UBE2L6_uc001nko.1_Silent_p.F77F	NM_004223	NP_004214	O14933	UB2L6_HUMAN	ubiquitin-conjugating enzyme E2L 6 isoform 1	143					negative regulation of type I interferon production	cytosol	protein binding|ubiquitin-protein ligase activity			ovary(1)	1						ATCGGAGGGTGAACTCTTCGG	0.572		NaN											0	0	0	0.01441	0	71	99									
SIPA1	6494	broad.mit.edu	37	11	65417623	65417623	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:65417623G>C	uc001ofb.2	+	14	3030	c.2863G>C	c.(2863-2865)GAG>CAG	p.E955Q	SIPA1_uc010rom.1_Missense_Mutation_p.E853Q|SIPA1_uc001ofd.2_Missense_Mutation_p.E955Q	NM_006747	NP_006738	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated protein	955					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity				0						GCCCATCCCAGAGAGTGGAGA	0.607		NaN											0	0	0	0.01441	0	43	76									
MTL5	9633	broad.mit.edu	37	11	68517984	68517984	+	Missense_Mutation	SNP	A	A	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:68517984A>T	uc001ooc.2	-	2	285	c.145T>A	c.(145-147)TTC>ATC	p.F49I	MTL5_uc001ood.1_Missense_Mutation_p.F49I|MTL5_uc009ysi.1_Missense_Mutation_p.F49I|MTL5_uc001ooe.2_Missense_Mutation_p.F49I	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	49					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			GCTTCTTTGAAGACGTGGAAC	0.647		NaN											0	0	0	0.000602	0	5	15									
CHORDC1	26973	broad.mit.edu	37	11	89956187	89956187	+	Translation_Start_Site	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:89956187C>T	uc001pdg.2	-	1	346	c.-64G>A	c.(-66--62)GAGTG>GAATG		CHORDC1_uc009yvz.2_Translation_Start_Site	NM_012124	NP_036256	Q9UHD1	CHRD1_HUMAN	cysteine and histidine-rich domain-containing						chaperone-mediated protein folding|regulation of response to stress|response to stress		Hsp90 protein binding|identical protein binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.00915)				GCGTTTGCCACTCCCGTGTCG	0.602		NaN											0	0	0	0.00308	0	7	12									
ADAMTS8	11095	broad.mit.edu	37	11	130275730	130275730	+	Missense_Mutation	SNP	A	A	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:130275730A>T	uc001qgg.3	-	9	2751	c.2393T>A	c.(2392-2394)TTC>TAC	p.F798Y	ADAMTS8_uc001qgf.2_Missense_Mutation_p.F279Y	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	798	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TTTTGGGGGGAAGACCTCGCC	0.567		NaN											0	0	0	0.01441	0	110	34									
CACNA1C	775	broad.mit.edu	37	12	2786965	2786965	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:2786965G>A	uc009zdu.1	+	43	5480	c.5167G>A	c.(5167-5169)GCT>ACT	p.A1723T	CACNA1C_uc009zdv.1_Missense_Mutation_p.A1672T|CACNA1C_uc001qkb.2_Missense_Mutation_p.A1675T|CACNA1C_uc001qkc.2_Missense_Mutation_p.A1694T|CACNA1C_uc001qke.2_Missense_Mutation_p.A1664T|CACNA1C_uc001qkf.2_Missense_Mutation_p.A1683T|CACNA1C_uc001qjz.2_Missense_Mutation_p.A1675T|CACNA1C_uc001qkd.2_Missense_Mutation_p.A1694T|CACNA1C_uc001qkg.2_Missense_Mutation_p.A1681T|CACNA1C_uc009zdw.1_Missense_Mutation_p.A1716T|CACNA1C_uc001qkh.2_Missense_Mutation_p.A1683T|CACNA1C_uc001qkl.2_Missense_Mutation_p.A1723T|CACNA1C_uc001qkn.2_Missense_Mutation_p.A1675T|CACNA1C_uc001qko.2_Missense_Mutation_p.A1695T|CACNA1C_uc001qkp.2_Missense_Mutation_p.A1675T|CACNA1C_uc001qkr.2_Missense_Mutation_p.A1692T|CACNA1C_uc001qku.2_Missense_Mutation_p.A1675T|CACNA1C_uc001qkq.2_Missense_Mutation_p.A1703T|CACNA1C_uc001qks.2_Missense_Mutation_p.A1675T|CACNA1C_uc001qkt.2_Missense_Mutation_p.A1694T|CACNA1C_uc001qki.1_Missense_Mutation_p.A1411T|CACNA1C_uc001qkj.1_Missense_Mutation_p.A1411T|CACNA1C_uc001qkk.1_Missense_Mutation_p.A1411T|CACNA1C_uc001qkm.1_Missense_Mutation_p.A1400T|CACNA1C_uc010sea.1_Missense_Mutation_p.A366T|uc001qkx.1_RNA|CACNA1C_uc001qky.1_5'UTR	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1723	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AGATCTCACCGCTGAGGAGGA	0.612		NaN											0	0	0	0.008361	0	30	18									
ATN1	1822	broad.mit.edu	37	12	7043167	7043167	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:7043167G>A	uc001qrw.1	+	2	240	c.3G>A	c.(1-3)ATG>ATA	p.M1I	ATN1_uc001qrx.1_Missense_Mutation_p.M1I|ATN1_uc001qry.1_Missense_Mutation_p.M1I	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	1					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CCTGAAGAATGAAGACACGAC	0.517		NaN											0	0	0	0.001168	0	6	12									
CD163	9332	broad.mit.edu	37	12	7655119	7655119	+	Missense_Mutation	SNP	T	T	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:7655119T>G	uc001qsz.3	-	2	216	c.88A>C	c.(88-90)ACT>CCT	p.T30P	CD163_uc001qta.3_Missense_Mutation_p.T30P|CD163_uc009zfw.2_Missense_Mutation_p.T30P	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	30					acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						aagaccacagtaatggtgaag	0.234		NaN											0	0	0	0.004672	0	2	5									
A2ML1	144568	broad.mit.edu	37	12	8988145	8988145	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:8988145C>T	uc001quz.3	+	6	624	c.526C>T	c.(526-528)CCT>TCT	p.P176S		NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	20						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						GGAAGTGGTACCTGAGCAAGG	0.527		NaN											0	0	0	0.006122	0	17	53									
A2M	2	broad.mit.edu	37	12	9232332	9232332	+	Silent	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:9232332G>C	uc001qvk.1	-	24	3047	c.2934C>G	c.(2932-2934)GTC>GTG	p.V978V	A2M_uc001qvj.1_Silent_p.V20V|A2M_uc009zgk.1_Silent_p.V828V	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	978					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GAGCAAAGAGGACCATATTCT	0.453		NaN											0	0	0	0.001984	0	5	7									
GPR19	2842	broad.mit.edu	37	12	12814505	12814505	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:12814505T>C	uc001rar.3	-	2	1071	c.878A>G	c.(877-879)CAT>CGT	p.H293R	GPR19_uc001raq.2_Missense_Mutation_p.H293R	NM_006143	NP_006134	Q15760	GPR19_HUMAN	G protein-coupled receptor 19	293	Helical; Name=6; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		CTGAGCTACATGAAAAGGCAG	0.408		NaN											0	0	0	0.004482	0	9	23									
PLEKHA9	51054	broad.mit.edu	37	12	45567437	45567437	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:45567437A>G	uc001rom.1	-	3	1249	c.712T>C	c.(712-714)TTT>CTT	p.F238L	PLEKHA9_uc009zke.2_Missense_Mutation_p.F238L	NM_015899	NP_056983			pleckstrin homology domain containing, family A												0	Lung SC(27;0.192)|Renal(347;0.236)			GBM - Glioblastoma multiforme(48;0.173)		ACAGGAGCAAACACTGTAGGG	0.393		NaN											0	0	0	0.01441	0	70	70									
ESPL1	9700	broad.mit.edu	37	12	53670542	53670542	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:53670542G>A	uc001sck.2	+	8	1930	c.1839G>A	c.(1837-1839)CTG>CTA	p.L613L	ESPL1_uc001scj.2_Silent_p.L288L|ESPL1_uc010soe.1_5'Flank	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	613					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						TCCTGGAGCTGAGCCCCGAGG	0.642		NaN											0	0	0	0.003163	0	15	52									
MMP19	4327	broad.mit.edu	37	12	56236139	56236139	+	Silent	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:56236139C>A	uc001sib.2	-	2	292	c.171G>T	c.(169-171)CTG>CTT	p.L57L	MMP19_uc001sia.2_5'Flank|MMP19_uc001sid.2_RNA|MMP19_uc010spw.1_Silent_p.L57L	NM_002429	NP_002420	Q99542	MMP19_HUMAN	matrix metalloproteinase 19 isoform rasi-1	57					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)	1						CTTCTCACCTCAGAGCCTCGG	0.502		NaN											1	0	1.64293e-13	0.00333	1.79891e-13	24	74									
LRP1	4035	broad.mit.edu	37	12	57550039	57550039	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:57550039A>G	uc001snd.2	+	9	1856	c.1390A>G	c.(1390-1392)ATC>GTC	p.I464V		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	464	Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGCCCTCCACATCTACCACCA	0.607		NaN											0	0	0	0.00308	0	8	39									
GLI1	2735	broad.mit.edu	37	12	57865459	57865459	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:57865459A>G	uc001snx.2	+	12	3014	c.2936A>G	c.(2935-2937)AAT>AGT	p.N979S	GLI1_uc009zpq.2_Missense_Mutation_p.N851S	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	979					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			GTGGGGGCAAATAGGGCTTCA	0.537		NaN											0	0	0	0.004656	0	27	86									
E2F7	144455	broad.mit.edu	37	12	77458337	77458337	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:77458337C>G	uc001sym.3	-	2	315	c.79G>C	c.(79-81)GAA>CAA	p.E27Q	E2F7_uc001syn.2_Missense_Mutation_p.E27Q	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	27					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						TGTGCATTTTCCCCATCTTCA	0.373		NaN											0	0	0	0.010504	0	19	58									
KERA	11081	broad.mit.edu	37	12	91449916	91449916	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:91449916C>G	uc001tbl.2	-	2	762	c.143G>C	c.(142-144)TGC>TCC	p.C48S		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	48	LRRNT.|Cys-rich.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						ACTGGGTGGGCAGAAACATTC	0.393		NaN											0	0	0	0.000602	0	4	6									
IKBIP	121457	broad.mit.edu	37	12	99038453	99038453	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:99038453C>A	uc001tfv.2	-	1	137	c.27G>T	c.(25-27)AAG>AAT	p.K9N	APAF1_uc001tfy.2_5'Flank|APAF1_uc001tfz.2_5'Flank|APAF1_uc001tga.2_5'Flank|APAF1_uc001tgb.2_5'Flank|APAF1_uc001tgc.2_5'Flank|IKBIP_uc001tfw.2_Missense_Mutation_p.K9N|IKBIP_uc001tfx.2_Missense_Mutation_p.K9N	NM_201612	NP_963906	Q70UQ0	IKIP_HUMAN	IKK interacting protein isoform 2	9					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding				0						TGGGCCCCGACTTCTTCCGGC	0.706		NaN											1	0	1.05317e-09	0.00245	1.13167e-09	12	34									
UTP20	27340	broad.mit.edu	37	12	101745949	101745949	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:101745949G>C	uc001tia.1	+	39	5157	c.5001G>C	c.(4999-5001)CAG>CAC	p.Q1667H		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	1667					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						AAACGGGACAGATCAATCAAA	0.299		NaN											0	0	0	0.001855	0	12	43									
UTP20	27340	broad.mit.edu	37	12	101760349	101760349	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:101760349C>T	uc001tia.1	+	47	6295	c.6139C>T	c.(6139-6141)CCA>TCA	p.P2047S		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2047					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						TCCAGTAGCCCCAGCACCAGA	0.512		NaN											0	0	0	0.01441	0	45	39									
DNAH10	196385	broad.mit.edu	37	12	124341734	124341734	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:124341734C>T	uc001uft.3	+	36	6241	c.6216C>T	c.(6214-6216)GAC>GAT	p.D2072D		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2072					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GCTACCCTGACTTCAACGATG	0.532		NaN											0	0	0	0.00499	0	17	54									
EP400	57634	broad.mit.edu	37	12	132547093	132547093	+	Silent	SNP	A	A	G	rs28513925	by1000genomes	TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:132547093A>G	uc001ujn.2	+	46	8216	c.8181A>G	c.(8179-8181)CAA>CAG	p.Q2727Q	EP400_uc001ujl.2_Silent_p.Q2726Q|EP400_uc001ujm.2_Silent_p.Q2646Q|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Poly-Gln.|Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagc	0.294		NaN											0	0	0	0.004672	0	3	55									
FAM124A	220108	broad.mit.edu	37	13	51855235	51855235	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr13:51855235G>T	uc001vfg.1	+	4	1615	c.1484G>T	c.(1483-1485)CGT>CTT	p.R495L	FAM124A_uc001vff.1_Missense_Mutation_p.R531L	NM_145019	NP_659456	Q86V42	F124A_HUMAN	hypothetical protein LOC220108	495										central_nervous_system(1)	1		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		GCGACAGCTCGTGCTGCTCCC	0.612		NaN											1	0	1.39806e-14	0.008361	1.54545e-14	28	46									
ABCC4	10257	broad.mit.edu	37	13	95840790	95840790	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr13:95840790C>T	uc001vmd.3	-	10	1389	c.1270G>A	c.(1270-1272)GAG>AAG	p.E424K	ABCC4_uc010afk.2_Missense_Mutation_p.E424K|ABCC4_uc001vme.2_Missense_Mutation_p.E424K|ABCC4_uc010tih.1_Missense_Mutation_p.E349K|ABCC4_uc001vmf.2_Missense_Mutation_p.E381K|ABCC4_uc010afl.1_Missense_Mutation_p.E381K|ABCC4_uc010afm.1_Missense_Mutation_p.E437K	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	424	ABC transporter 1.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	GTTGGGGTCTCTGATGCCTAC	0.418		NaN											0	0	0	0.00333	0	25	49									
AP1G2	8906	broad.mit.edu	37	14	24029009	24029009	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:24029009C>T	uc001wkl.2	-	22	2644	c.2307G>A	c.(2305-2307)TCG>TCA	p.S769S	AP1G2_uc001wkj.2_Silent_p.S388S|AP1G2_uc001wkk.3_Silent_p.S697S|AP1G2_uc001wkn.2_Silent_p.S388S|uc001wko.1_5'Flank	NM_003917	NP_003908	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2	769	GAE.				interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			ovary(1)	1	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		TCTCCTGCACCGACTGGTGAA	0.562		NaN									OREG0022604	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	9	39									
NYNRIN	57523	broad.mit.edu	37	14	24884981	24884981	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:24884981C>T	uc001wpf.3	+	9	4344	c.4026C>T	c.(4024-4026)TCC>TCT	p.S1342S		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1342					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						TCTCCCTTTCCTTCTCCTGCT	0.607		NaN											0	0	0	0.01441	0	96	122									
FOXA1	3169	broad.mit.edu	37	14	38061313	38061313	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:38061313C>T	uc001wuf.2	-	2	988	c.676G>A	c.(676-678)GAC>AAC	p.D226N	FOXA1_uc010tpz.1_Missense_Mutation_p.D193N	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	226	Fork-head.				chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		ACGAAGCAGTCATTGAAGGAC	0.607		NaN											0	0	0	0.00874	0	35	30									
NIN	51199	broad.mit.edu	37	14	51224125	51224125	+	Missense_Mutation	SNP	A	A	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:51224125A>T	uc001wym.2	-	18	3814	c.3623T>A	c.(3622-3624)ATG>AAG	p.M1208K	NIN_uc001wyi.2_Missense_Mutation_p.M1208K|NIN_uc001wyj.2_Intron|NIN_uc001wyk.2_Intron|NIN_uc010tqp.1_Missense_Mutation_p.M1214K|NIN_uc001wyo.2_Missense_Mutation_p.M1208K	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1208	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					ACATAACATCATTAGCTGTTC	0.418		NaN	T	PDGFRB	MPD								0	0	0	0.01441	0	51	80									
KTN1	3895	broad.mit.edu	37	14	56107858	56107858	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:56107858G>C	uc001xcb.2	+	18	2337	c.2035G>C	c.(2035-2037)GAT>CAT	p.D679H	KTN1_uc001xce.2_Missense_Mutation_p.D679H|KTN1_uc001xcc.2_Missense_Mutation_p.D679H|KTN1_uc001xcd.2_Missense_Mutation_p.D679H|KTN1_uc010trb.1_Missense_Mutation_p.D679H|KTN1_uc001xcf.1_Missense_Mutation_p.D679H	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	679	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						TTATGTTAAAGATGATAAAAT	0.303		NaN	T	RET	papillary thryoid								0	0	0	0.001984	0	7	14									
C14orf37	145407	broad.mit.edu	37	14	58605192	58605192	+	Missense_Mutation	SNP	T	T	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:58605192T>G	uc001xdc.2	-	2	996	c.885A>C	c.(883-885)GAA>GAC	p.E295D	C14orf37_uc010tro.1_Missense_Mutation_p.E333D|C14orf37_uc001xdd.2_Missense_Mutation_p.E295D|C14orf37_uc001xde.2_Missense_Mutation_p.E295D	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	295	Extracellular (Potential).					integral to membrane	binding				0						TCACTGTGACTTCTGGGGCTC	0.532		NaN											0	0	0	0.00874	0	44	69									
C14orf37	145407	broad.mit.edu	37	14	58605935	58605935	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:58605935C>A	uc001xdc.2	-	2	253	c.142G>T	c.(142-144)GAT>TAT	p.D48Y	C14orf37_uc010tro.1_Missense_Mutation_p.D86Y|C14orf37_uc001xdd.2_Missense_Mutation_p.D48Y|C14orf37_uc001xde.2_Missense_Mutation_p.D48Y	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	48	Extracellular (Potential).					integral to membrane	binding				0						TTCATCTTATCGGACTGCCCT	0.478		NaN											1	0	1.42676e-28	0.01441	1.64553e-28	62	106									
ACOT2	10965	broad.mit.edu	37	14	74040235	74040235	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:74040235G>C	uc001xon.3	+	2	960	c.787G>C	c.(787-789)GAG>CAG	p.E263Q	ACOT1_uc010tuc.1_Intron|ACOT2_uc001xom.2_Missense_Mutation_p.E66Q	NM_006821	NP_006812	P49753	ACOT2_HUMAN	acyl-CoA thioesterase 2	263					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	mitochondrion	carboxylesterase activity|palmitoyl-CoA hydrolase activity|protein binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.0639)		CAAGACCATGGAGACGCTCCA	0.488		NaN											0	0	0	0.01441	0	60	101									
ANGEL1	23357	broad.mit.edu	37	14	77273074	77273074	+	Silent	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:77273074G>T	uc001xsv.2	-	5	1178	c.1065C>A	c.(1063-1065)GGC>GGA	p.G355G	ANGEL1_uc010tvf.1_Intron	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	355										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		GTAGCTCCAAGCCAGGCCGGA	0.572		NaN											1	0	1.73998e-50	0.01441	2.02705e-50	108	130									
C15orf55	256646	broad.mit.edu	37	15	34648800	34648800	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr15:34648800G>A	uc001zif.2	+	7	2662	c.2507G>A	c.(2506-2508)TGG>TAG	p.W836*	C15orf55_uc010ucc.1_Nonsense_Mutation_p.W864*|C15orf55_uc010ucd.1_Nonsense_Mutation_p.W854*	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	836						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		AGTGATCTGTGGGCAGAAGGT	0.517		NaN	T	BRD3|BRD4	lethal midline carcinoma								0	0	0	0.00499	0	14	36									
SLC30A4	7782	broad.mit.edu	37	15	45814250	45814250	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr15:45814250C>T	uc001zvj.2	-	2	615	c.303G>A	c.(301-303)CAG>CAA	p.Q101Q	C15orf21_uc010beg.1_Intron|C15orf21_uc010beh.1_Intron|C15orf21_uc010bei.1_Intron|C15orf21_uc010bej.1_Intron|C15orf21_uc001zvm.1_Intron|C15orf21_uc001zvn.1_Intron	NM_013309	NP_037441	O14863	ZNT4_HUMAN	solute carrier family 30 (zinc transporter),	101	Cytoplasmic (Potential).				regulation of sequestering of zinc ion|response to toxin	endosome membrane|integral to membrane|late endosome	zinc ion transmembrane transporter activity				0		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.58e-16)|GBM - Glioblastoma multiforme(94;2.15e-06)		GTATCTCTCTCTGTTTGCTGC	0.478		NaN											0	0	0	0.005524	0	36	87									
AP4E1	23431	broad.mit.edu	37	15	51289630	51289630	+	Missense_Mutation	SNP	T	T	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr15:51289630T>A	uc001zyx.1	+	18	2484	c.2454T>A	c.(2452-2454)TTT>TTA	p.F818L	AP4E1_uc010bex.1_RNA	NM_007347	NP_031373	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1	818					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity				0				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		GTTCTTCCTTTAGTTCTTTGT	0.353		NaN											0	0	0	0.000602	0	4	13									
SMAD3	4088	broad.mit.edu	37	15	67479786	67479786	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr15:67479786C>A	uc002aqj.2	+	8	1391	c.1093C>A	c.(1093-1095)CAG>AAG	p.Q365K	SMAD3_uc010ujr.1_Missense_Mutation_p.Q260K|SMAD3_uc010ujs.1_Missense_Mutation_p.Q321K|SMAD3_uc010ujt.1_Missense_Mutation_p.Q170K	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	365	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		GGCTGTCTACCAGTTGACCCG	0.557		NaN											1	0	6.60958e-23	0.01441	7.52274e-23	59	34									
ALPK3	57538	broad.mit.edu	37	15	85401422	85401422	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr15:85401422C>T	uc002ble.2	+	6	4226	c.4059C>T	c.(4057-4059)CTC>CTT	p.L1353L		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1353					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGACAGGTCTCCCGGCAGCTA	0.642		NaN											0	0	0	0.000602	0	3	14									
USP31	57478	broad.mit.edu	37	16	23083506	23083506	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:23083506G>A	uc002dll.2	-	15	2348	c.2348C>T	c.(2347-2349)TCT>TTT	p.S783F	USP31_uc002dlk.2_Missense_Mutation_p.S55F|USP31_uc010vca.1_Missense_Mutation_p.S86F|USP31_uc010bxm.2_Missense_Mutation_p.S71F	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	783	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		ACACAGGGAAGAACTTGTGGA	0.622		NaN											0	0	0	0.007413	0	20	27									
TNRC6A	27327	broad.mit.edu	37	16	24802570	24802570	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:24802570C>T	uc002dmm.2	+	6	2721	c.2607C>T	c.(2605-2607)GCC>GCT	p.A869A	TNRC6A_uc010bxs.2_Silent_p.A616A|TNRC6A_uc010vcc.1_Silent_p.A616A|TNRC6A_uc002dmn.2_Silent_p.A616A|TNRC6A_uc002dmo.2_Silent_p.A616A	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	869	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GGGGTGAGGCCAATAAGAAAT	0.463		NaN											0	0	0	0.000602	0	5	48									
APOB48R	55911	broad.mit.edu	37	16	28509168	28509168	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:28509168G>C	uc002dqb.1	+	3	2789	c.2779G>C	c.(2779-2781)GAG>CAG	p.E927Q	uc010vct.1_Intron|APOB48R_uc010byg.1_Missense_Mutation_p.E465Q	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	927	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						CAAGGAGACTGAGCCAGAAAG	0.662		NaN											0	0	0	0.001984	0	7	10									
CORO1A	11151	broad.mit.edu	37	16	30199868	30199868	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:30199868G>A	uc002dww.2	+	10	1374	c.1252G>A	c.(1252-1254)GCA>ACA	p.A418T	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010bzq.2_Missense_Mutation_p.A418T|CORO1A_uc010bzr.2_Intron|CORO1A_uc002dwx.2_Missense_Mutation_p.A312T|CORO1A_uc002dwy.1_3'UTR|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	418					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0						CAGGAGGGCAGCACCAGAGGC	0.657		NaN											0	0	0	0.012319	0	21	16									
POLR2C	5432	broad.mit.edu	37	16	57504205	57504205	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:57504205T>C	uc002elt.1	+	8	708	c.622T>C	c.(622-624)TAC>CAC	p.Y208H		NM_032940	NP_116558	P19387	RPB3_HUMAN	DNA directed RNA polymerase II polypeptide C	208					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0						AAAGAGTGAGTACTCGGAGCT	0.547		NaN											0	0	0	0.008291	0	10	14									
CIRH1A	84916	broad.mit.edu	37	16	69199282	69199282	+	Silent	SNP	T	T	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:69199282T>C	uc002ews.3	+	15	1782	c.1686T>C	c.(1684-1686)GAT>GAC	p.D562D	CIRH1A_uc002ewr.2_Silent_p.D562D|CIRH1A_uc002ewt.3_Silent_p.D479D|CIRH1A_uc010cfi.2_Silent_p.D364D	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	562	WD 11.					nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		AGTATACAGATTGGAGCCGGA	0.488		NaN											0	0	0	0.003755	0	32	44									
RFWD3	55159	broad.mit.edu	37	16	74695239	74695239	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:74695239G>A	uc002fda.2	-	2	207	c.109C>T	c.(109-111)CAG>TAG	p.Q37*	RFWD3_uc010cgq.2_Nonsense_Mutation_p.Q37*	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	37					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						GGAACAGGCTGGAGGAGGGCT	0.587		NaN											0	0	0	0.01441	0	93	124									
CLEC3A	10143	broad.mit.edu	37	16	78064707	78064707	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:78064707G>C	uc002ffh.3	+	3	644	c.563G>C	c.(562-564)AGA>ACA	p.R188T		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	188	C-type lectin.				skeletal system development	extracellular region	sugar binding				0						AGCAGCAAGAGATACATATGC	0.483		NaN											0	0	0	0.00308	0	7	41									
IL17C	27189	broad.mit.edu	37	16	88706293	88706293	+	Missense_Mutation	SNP	A	A	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:88706293A>C	uc002fla.2	+	3	456	c.407A>C	c.(406-408)GAT>GCT	p.D136A		NM_013278	NP_037410	Q9P0M4	IL17C_HUMAN	interleukin 17C precursor	136					cell surface receptor linked signaling pathway|cell-cell signaling|inflammatory response	extracellular space|soluble fraction	cytokine activity				0				BRCA - Breast invasive adenocarcinoma(80;0.0477)		GGCTGTATCGATGCACGGACG	0.687		NaN											0	0	0	0.008291	0	11	9									
ZNF778	197320	broad.mit.edu	37	16	89294114	89294114	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:89294114G>C	uc002fmv.2	+	6	1673	c.1334G>C	c.(1333-1335)GGA>GCA	p.G445A	ZNF778_uc010vpf.1_Intron|ZNF778_uc002fmw.1_Missense_Mutation_p.G403A|ZNF778_uc010vpg.1_Missense_Mutation_p.G208A	NM_182531	NP_872337	Q96MU6	ZN778_HUMAN	zinc finger protein 778	445					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0269)		ACTCACACTGGAGAGAAACCA	0.493		NaN											0	0	0	0.01441	0	52	63									
ANKRD11	29123	broad.mit.edu	37	16	89346334	89346334	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:89346334C>G	uc002fmx.1	-	9	7077	c.6616G>C	c.(6616-6618)GAG>CAG	p.E2206Q	ANKRD11_uc002fmy.1_Missense_Mutation_p.E2206Q|ANKRD11_uc002fnc.1_Missense_Mutation_p.E2206Q|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Missense_Mutation_p.E2163Q	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2206	Pro-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CCTGAGGGCTCAGGCTCGAGC	0.672		NaN											0	0	0	0.004482	0	8	18									
ANKRD11	29123	broad.mit.edu	37	16	89357082	89357082	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:89357082G>A	uc002fmx.1	-	6	1013	c.552C>T	c.(550-552)ATC>ATT	p.I184I	ANKRD11_uc002fmy.1_Silent_p.I184I|ANKRD11_uc002fnc.1_Silent_p.I184I|ANKRD11_uc002fnd.2_Silent_p.I150I|ANKRD11_uc002fne.2_Silent_p.I150I|ANKRD11_uc002fnb.1_Silent_p.I141I	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	184	ANK 1.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TGAGCTCTTTGATGCGCCGGG	0.622		NaN											0	0	0	0.01441	0	40	59									
ANKRD11	29123	broad.mit.edu	37	16	89357086	89357086	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:89357086C>T	uc002fmx.1	-	6	1009	c.548G>A	c.(547-549)CGC>CAC	p.R183H	ANKRD11_uc002fmy.1_Missense_Mutation_p.R183H|ANKRD11_uc002fnc.1_Missense_Mutation_p.R183H|ANKRD11_uc002fnd.2_Missense_Mutation_p.R149H|ANKRD11_uc002fne.2_Missense_Mutation_p.R149H|ANKRD11_uc002fnb.1_Missense_Mutation_p.R140H	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	183	ANK 1.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CTCTTTGATGCGCCGGGCGTC	0.627		NaN											0	0	0	0.01441	0	41	59									
FANCA	2175	broad.mit.edu	37	16	89857865	89857865	+	Silent	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:89857865G>C	uc002fou.1	-	14	1347	c.1305C>G	c.(1303-1305)CGC>CGG	p.R435R	FANCA_uc010vpn.1_Silent_p.R435R	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	435			R -> C (in FA).		DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GTGCTGCCTGGCGCACAACCA	0.552		NaN	D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.007413	0	18	18									
MYO1C	4641	broad.mit.edu	37	17	1381474	1381474	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:1381474G>A	uc002fsp.2	-	12	1528	c.1308C>T	c.(1306-1308)TTC>TTT	p.F436F	MYO1C_uc002fsn.2_Silent_p.F417F|MYO1C_uc002fso.2_Silent_p.F401F|MYO1C_uc010vqj.1_Silent_p.F401F|MYO1C_uc010vqk.1_Silent_p.F412F	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	436	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		AATTGATGCAGAACTGCTCAA	0.582		NaN											0	0	0	0.009535	0	32	14									
TP53	7157	broad.mit.edu	37	17	7578478	7578478	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:7578478G>T	uc002gim.2	-	5	646	c.452C>A	c.(451-453)CCC>CAC	p.P151H	TP53_uc002gig.1_Missense_Mutation_p.P151H|TP53_uc002gih.2_Missense_Mutation_p.P151H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P19H|TP53_uc010cng.1_Missense_Mutation_p.P19H|TP53_uc002gii.1_Missense_Mutation_p.P19H|TP53_uc010cnh.1_Missense_Mutation_p.P151H|TP53_uc010cni.1_Missense_Mutation_p.P151H|TP53_uc002gij.2_Missense_Mutation_p.P151H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.P58H|TP53_uc002gio.2_Missense_Mutation_p.P19H|TP53_uc010vug.1_Missense_Mutation_p.P112H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	151	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151S(61)|p.P151H(25)|p.P151T(13)|p.P151P(12)|p.P151A(8)|p.0?(7)|p.P151fs*30(7)|p.P151L(6)|p.P151R(6)|p.T150fs*16(3)|p.P151_V173del23(1)|p.P152_P153del(1)|p.P152fs*28(1)|p.P151del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.P153fs*28(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P152fs*14(1)|p.T150_P151delTP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCGGGCGGGGGTGTGGAATC	0.607		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	7.92952e-12	0.003954	8.5738e-12	23	8									
MYH3	4621	broad.mit.edu	37	17	10542927	10542927	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:10542927C>T	uc002gmq.1	-	22	2952	c.2875G>A	c.(2875-2877)GAG>AAG	p.E959K		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	959	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						AGGGTCAACTCAAGGTCATCA	0.453		NaN											0	0	0	0.01441	0	127	56									
NEK8	284086	broad.mit.edu	37	17	27065197	27065197	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:27065197G>A	uc002hcp.2	+	8	1156	c.1156G>A	c.(1156-1158)GAG>AAG	p.E386K		NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	386						cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					GCGTTTCCTGGAGGGCCAGTC	0.657		NaN											0	0	0	0.007413	0	16	31									
NEK8	284086	broad.mit.edu	37	17	27065214	27065214	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:27065214G>A	uc002hcp.2	+	8	1173	c.1173G>A	c.(1171-1173)GTG>GTA	p.V391V		NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	391						cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					AGTCGGGTGTGACCATCAAGC	0.642		NaN											0	0	0	0.010504	0	19	33									
PSMD11	5717	broad.mit.edu	37	17	30800897	30800897	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:30800897C>G	uc010cta.1	+	7	762	c.722C>G	c.(721-723)TCC>TGC	p.S241C	PSMD11_uc010wbz.1_Missense_Mutation_p.S241C|PSMD11_uc002hhm.2_Missense_Mutation_p.S241C	NM_002815	NP_002806	O00231	PSD11_HUMAN	proteasome 26S non-ATPase subunit 11	241	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			GGTTATGACTCCATCGACAGC	0.453		NaN											0	0	0	0.009096	0	4	73									
MLLT6	4302	broad.mit.edu	37	17	36872640	36872640	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:36872640C>G	uc002hqi.3	+	10	1070	c.1057C>G	c.(1057-1059)CCT>GCT	p.P353A	MLLT6_uc002hqj.2_Intron|MLLT6_uc002hqk.3_5'Flank	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	353					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					GCAGAGCTCCCCTGACTTCTC	0.622		NaN	T	MLL	AL								0	0	0	0.007413	0	18	28									
KRT39	390792	broad.mit.edu	37	17	39116697	39116697	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:39116697C>T	uc002hvo.1	-	6	1089	c.1053G>A	c.(1051-1053)CTG>CTA	p.L351L	KRT39_uc010wfm.1_Silent_p.L84L	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	351	Coil 2.|Rod.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				GGATCTGGGTCAGCAAGGCCG	0.502		NaN											0	0	0	0.01441	0	45	85									
CD300LG	146894	broad.mit.edu	37	17	41925958	41925958	+	Missense_Mutation	SNP	A	A	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:41925958A>T	uc002iem.2	+	2	117	c.76A>T	c.(76-78)AGC>TGC	p.S26C	CD300LG_uc002iek.1_Missense_Mutation_p.S26C|CD300LG_uc002iel.1_Missense_Mutation_p.S26C|CD300LG_uc010czk.2_Missense_Mutation_p.S26C|CD300LG_uc010wil.1_Missense_Mutation_p.S26C|CD300LG_uc010czl.2_Missense_Mutation_p.S26C	NM_145273	NP_660316	Q6UXG3	CLM9_HUMAN	CD300 molecule-like family member g precursor	26	Extracellular (Potential).|Ig-like V-type.					apical plasma membrane|basolateral plasma membrane|integral to membrane|multivesicular body membrane	receptor activity				0		Breast(137;0.0199)		BRCA - Breast invasive adenocarcinoma(366;0.115)		AGAGGAAATCAGCGGGTTCGA	0.562		NaN											0	0	0	0.004289	0	35	55									
GPATCH8	23131	broad.mit.edu	37	17	42475276	42475276	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:42475276G>A	uc002igw.1	-	8	4233	c.4169C>T	c.(4168-4170)GCC>GTC	p.A1390V	GPATCH8_uc002igv.1_Missense_Mutation_p.A1312V|GPATCH8_uc010wiz.1_Missense_Mutation_p.A1312V	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1390	Poly-Ala.					intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		AATGCCGATGGCGGCAGCAGC	0.577		NaN											0	0	0	0.001984	0	6	38									
CLTC	1213	broad.mit.edu	37	17	57754351	57754351	+	Silent	SNP	T	T	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:57754351T>A	uc002ixq.1	+	17	3041	c.2598T>A	c.(2596-2598)ATT>ATA	p.I866I	CLTC_uc002ixp.2_Silent_p.I866I|CLTC_uc002ixr.1_Silent_p.I870I	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	866	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					AGGCCAGAATTCATGAGGGCT	0.408		NaN	T	ALK|TFE3	ALCL|renal 								0	0	0	0.00308	0	8	14									
CSH2	1443	broad.mit.edu	37	17	61949641	61949641	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:61949641G>A	uc002jch.2	-	5	614	c.499C>T	c.(499-501)CAG>TAG	p.Q167*	CSH2_uc002jcg.2_Nonsense_Mutation_p.Q72*|CSH2_uc002jci.2_3'UTR|GH2_uc002jcj.2_Silent_p.S165S|CSH2_uc002jck.2_Nonsense_Mutation_p.Q167*	NM_020991	NP_066271	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2 isoform 1	167					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding				0						CTGTAGGTCTGCTTGAGGATC	0.557		NaN											0	0	0	0.01441	0	76	106									
CSH2	1443	broad.mit.edu	37	17	61950572	61950572	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:61950572C>T	uc002jch.2	-	2	253	c.138G>A	c.(136-138)GCG>GCA	p.A46A	CSH2_uc002jcg.2_Silent_p.A46A|CSH2_uc002jci.2_Silent_p.A46A|GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Silent_p.A46A	NM_020991	NP_066271	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2 isoform 1	46					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding				0						CCAGCTGGTGCGCGCGATGGG	0.592		NaN											0	0	0	0.006999	0	21	112									
SCN4A	6329	broad.mit.edu	37	17	62018842	62018842	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:62018842G>T	uc002jds.1	-	24	4877	c.4800C>A	c.(4798-4800)AAC>AAA	p.N1600K		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1600					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	CCACATTGAAGTTCTCCAGGA	0.532		NaN											1	0	1.57351e-24	0.003755	1.79682e-24	33	55									
PSMD12	5718	broad.mit.edu	37	17	65353674	65353674	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:65353674G>A	uc002jfy.2	-	2	215	c.129C>T	c.(127-129)GTC>GTT	p.V43V	PSMD12_uc002jga.2_Intron|PSMD12_uc002jfz.2_5'UTR|PSMD12_uc010det.1_Silent_p.V43V	NM_002816	NP_002807	O00232	PSD12_HUMAN	proteasome 26S non-ATPase subunit 12 isoform 1	43					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding				0	all_cancers(12;2.38e-11)|all_epithelial(3;8.27e-13)					GGGTTTCAATGACTTCTTGAA	0.333		NaN											0	0	0	0.004289	0	35	139									
RNF213	57674	broad.mit.edu	37	17	78320135	78320135	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:78320135C>G	uc002jyh.1	+	4	2442	c.2219C>G	c.(2218-2220)TCC>TGC	p.S740C		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GCCTTTCTCTCCAAGTCCAGC	0.532		NaN											0	0	0	0.007413	0	20	59									
B3GNTL1	146712	broad.mit.edu	37	17	81006550	81006550	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:81006550T>C	uc002kgg.1	-	2	186	c.172A>G	c.(172-174)AGT>GGT	p.S58G	B3GNTL1_uc002kgf.1_5'UTR	NM_001009905	NP_001009905	Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal	58							transferase activity, transferring glycosyl groups			ovary(1)|pancreas(1)	2	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			CAAACCTTACTGGCATCATTG	0.507		NaN											0	0	0	0.01441	0	49	49									
C18orf8	29919	broad.mit.edu	37	18	21110004	21110004	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr18:21110004G>A	uc010xax.1	+	18	1628	c.1507G>A	c.(1507-1509)GAA>AAA	p.E503K	C18orf8_uc002kul.2_RNA|C18orf8_uc010xay.1_Missense_Mutation_p.E127K|NPC1_uc010dlu.1_Intron	NM_013326	NP_037458	Q96DM3	MIC1_HUMAN	colon cancer-associated protein Mic1	503	Mic1.									ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					TTACCTACATGAACTTGTTAT	0.433		NaN											0	0	0	0.01441	0	193	158									
MEP1B	4225	broad.mit.edu	37	18	29797898	29797898	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr18:29797898C>T	uc002kxj.3	+	14	2108	c.2061C>T	c.(2059-2061)AGC>AGT	p.S687S		NM_005925	NP_005916	Q16820	MEP1B_HUMAN	meprin A beta precursor	687	Cytoplasmic (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)	2						AAAGGATGAGCTCAAATCGAC	0.398		NaN											0	0	0	0.000602	0	4	22									
MEP1B	4225	broad.mit.edu	37	18	29797900	29797900	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr18:29797900C>A	uc002kxj.3	+	14	2110	c.2063C>A	c.(2062-2064)TCA>TAA	p.S688*		NM_005925	NP_005916	Q16820	MEP1B_HUMAN	meprin A beta precursor	688	Cytoplasmic (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)	2						AGGATGAGCTCAAATCGACCA	0.393		NaN											1	0	2.56e-06	0.009096	2.68412e-06	3	22									
C18orf22	79863	broad.mit.edu	37	18	77802217	77802217	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr18:77802217G>A	uc002lns.2	+	5	712	c.574G>A	c.(574-576)GAG>AAG	p.E192K	C18orf22_uc010drh.2_Intron|C18orf22_uc010dri.1_Intron|C18orf22_uc002lnt.2_Missense_Mutation_p.E25K	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	192					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		AGCTCTAGCTGAGGTAAGGTT	0.289		NaN											0	0	0	0.010729	0	11	24									
RAX2	84839	broad.mit.edu	37	19	3771575	3771575	+	Missense_Mutation	SNP	T	T	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:3771575T>G	uc002lys.2	-	2	234	c.166A>C	c.(166-168)AGC>CGC	p.S56R	RAX2_uc010dtp.1_RNA|RAX2_uc002lyr.2_Missense_Mutation_p.S102R	NM_032753	NP_116142	Q96IS3	RAX2_HUMAN	retina and anterior neural fold homeobox 2	56	Homeobox.				response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00463)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTCACGGCTGTACACATCC	0.637		NaN											0	0	0	0.010729	0	12	0									
PLIN4	729359	broad.mit.edu	37	19	4512576	4512576	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:4512576T>C	uc002mar.1	-	3	1354	c.1354A>G	c.(1354-1356)AAG>GAG	p.K452E	PLIN4_uc010dub.1_5'Flank	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	452	11.|27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane					0						ACAGTGTCCTTGGTACCAGTT	0.577		NaN											0	0	0	0.01441	0	91	24									
LONP1	9361	broad.mit.edu	37	19	5696709	5696709	+	Missense_Mutation	SNP	G	G	A	rs140317309		TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:5696709G>A	uc002mcx.2	-	11	1778	c.1745C>T	c.(1744-1746)ACG>ATG	p.T582M	LONP1_uc002mcy.2_Missense_Mutation_p.T518M|LONP1_uc010duh.2_Missense_Mutation_p.T323M|LONP1_uc010dui.2_Missense_Mutation_p.T566M|LONP1_uc002mcz.2_Missense_Mutation_p.T386M	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	582					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						GGGGTTCTCCGTCTTGGTCTT	0.632		NaN											0	0	0	0.008361	0	28	10									
DNM2	1785	broad.mit.edu	37	19	10883300	10883300	+	Silent	SNP	A	A	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:10883300A>G	uc002mps.1	+	3	545	c.381A>G	c.(379-381)CCA>CCG	p.P127P	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Silent_p.P127P|DNM2_uc002mpv.1_Silent_p.P127P|DNM2_uc002mpu.1_Silent_p.P127P|DNM2_uc010dxl.1_Silent_p.P127P	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	127					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TCTACTCGCCACACGGTAGGC	0.562		NaN											0	0	0	0.006122	0	17	11									
CC2D1A	54862	broad.mit.edu	37	19	14038827	14038827	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:14038827C>T	uc002mxo.2	+	23	2737	c.2438C>T	c.(2437-2439)CCG>CTG	p.P813L	CC2D1A_uc002mxp.2_Missense_Mutation_p.P813L|CC2D1A_uc010dzh.2_Missense_Mutation_p.P382L	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	813					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			GACCCTGTGCCGGCAGCTGTG	0.637		NaN											0	0	0	0.01441	0	52	24									
HNRNPUL1	11100	broad.mit.edu	37	19	41770556	41770556	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:41770556G>A	uc002oqb.3	+	1	437	c.148G>A	c.(148-150)GCC>ACC	p.A50T	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Intron|HNRNPUL1_uc002oqa.3_Intron|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.A50T|HNRNPUL1_uc002oqc.3_Intron|HNRNPUL1_uc002oqe.3_Missense_Mutation_p.A50T|HNRNPUL1_uc002oqd.3_5'UTR|HNRNPUL1_uc010ehn.2_5'Flank|HNRNPUL1_uc010eho.2_5'Flank|HNRNPUL1_uc010xvy.1_5'Flank|HNRNPUL1_uc010ehl.1_Intron	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	50	Necessary for interaction with HRMT1L1.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						GGAGCTCGACGCCGACGACGA	0.746		NaN											0	0	0	0.001168	0	5	19									
C19orf61	56006	broad.mit.edu	37	19	44251840	44251840	+	Silent	SNP	A	A	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:44251840A>G	uc002oxj.2	-	4	778	c.435T>C	c.(433-435)CCT>CCC	p.P145P	C19orf61_uc002oxk.2_Silent_p.P145P|C19orf61_uc010eiy.1_Silent_p.P145P	NM_019108	NP_061981	Q9H0W8	SMG9_HUMAN	SMG9 protein	145					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	intracellular	protein binding				0		Prostate(69;0.0352)				TCTGGTACACAGGCTGTGTGG	0.677		NaN											0	0	0	0.001168	0	6	18									
ERCC2	2068	broad.mit.edu	37	19	45855787	45855787	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:45855787C>T	uc002pbj.2	-	21	2070	c.2023G>A	c.(2023-2025)GGC>AGC	p.G675S	ERCC2_uc002pbh.2_Missense_Mutation_p.G238S|ERCC2_uc002pbi.2_Missense_Mutation_p.G368S|ERCC2_uc010ejz.2_Missense_Mutation_p.G597S|ERCC2_uc002pbk.2_Missense_Mutation_p.G651S	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	675			G -> R (in XP-D/CS; severe form).		cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		ACCATGAGGCCGTAGTCCGTC	0.597		NaN	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.004878	0	38	44									
EML2	24139	broad.mit.edu	37	19	46141892	46141893	+	Splice_Site	DNP	TC	TC	AA			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:46141892_46141893TC>AA	uc002pcn.2	-	3	85	c.50_splice	c.e3-1	p.E17_splice	EML2_uc002pco.2_Splice_Site|EML2_uc002pcp.2_Intron|EML2_uc010xxl.1_Splice_Site_p.E164_splice|EML2_uc010xxm.1_Splice_Site_p.E218_splice|EML2_uc010xxn.1_Splice_Site|EML2_uc010xxo.1_Splice_Site_p.E17_splice|EML2_uc010ekj.2_Splice_Site_p.E17_splice	NM_012155	NP_036287	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like						sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		GGAGCCATCCTCTGCCAGGACA	0.559		NaN											0	0	0	0.004672	0	22	90									
ZNF320	162967	broad.mit.edu	37	19	53384401	53384401	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:53384401C>T	uc002qag.2	-	4	1169	c.978G>A	c.(976-978)GAG>GAA	p.E326E	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Silent_p.E272E|ZNF320_uc002qai.2_Silent_p.E326E	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	326					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		TGTAAGGTTTCTCTCCAGTGT	0.403		NaN											0	0	0	0.012319	0	23	43									
LAIR2	3904	broad.mit.edu	37	19	55014120	55014121	+	Translation_Start_Site	DNP	TC	TC	AA			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:55014120_55014121TC>AA	uc002qgc.2	+	1	108_109	c.-14_-13TC>AA	c.(-16--11)GTTCTG>GTAATG		LAIR2_uc002qga.1_Intron|LAIR2_uc002qgb.1_Intron|LAIR2_uc002qgd.2_Translation_Start_Site|LAIR2_uc010erl.2_Translation_Start_Site	NM_002288	NP_002279	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like							extracellular region	receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		GCTGCAGAGTTCTGGGACCGGG	0.629		NaN											0	0	0	0.004672	0	11	72									
NLRP9	338321	broad.mit.edu	37	19	56243884	56243884	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:56243884C>G	uc002qly.2	-	2	1341	c.1313G>C	c.(1312-1314)GGG>GCG	p.G438A		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	438	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AAAACAGTCCCCTCTCCTTTG	0.483		NaN											0	0	0	0.01441	0	73	87									
NT5C1B	93034	broad.mit.edu	37	2	18764238	18764238	+	Missense_Mutation	SNP	A	A	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:18764238A>T	uc002rcz.2	-	7	1201	c.1097T>A	c.(1096-1098)CTC>CAC	p.L366H	NT5C1B_uc002rcy.2_Missense_Mutation_p.L366H|NT5C1B_uc010exr.2_Missense_Mutation_p.L308H|NT5C1B_uc010yju.1_Missense_Mutation_p.L306H|NT5C1B_uc002rda.2_Missense_Mutation_p.L306H|NT5C1B_uc010yjv.1_Missense_Mutation_p.L383H|NT5C1B_uc010yjw.1_Missense_Mutation_p.L349H|NT5C1B_uc010exs.2_Missense_Mutation_p.L368H	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	366					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				TAGATCACGGAGTCTAGCATT	0.473		NaN											0	0	0	0.004482	0	8	39									
RHOB	388	broad.mit.edu	37	2	20647740	20647740	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:20647740G>A	uc002rdv.2	+	1	906	c.514G>A	c.(514-516)GAG>AAG	p.E172K		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	172					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		CGAGGTCTTCGAGACGGCCAC	0.687		NaN											0	0	0	0.01441	0	58	75									
XDH	7498	broad.mit.edu	37	2	31562461	31562461	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:31562461C>T	uc002rnv.1	-	34	3747	c.3668G>A	c.(3667-3669)CGT>CAT	p.R1223H		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	1223					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GCTAGGGCCACGGGTGTGCAG	0.597		NaN											0	0	0	0.003271	0	35	56									
BIRC6	57448	broad.mit.edu	37	2	32626345	32626345	+	Silent	SNP	T	T	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:32626345T>C	uc010ezu.2	+	7	1283	c.1149T>C	c.(1147-1149)GAT>GAC	p.D383D		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	383					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTTGTACGGATGGAACTGACA	0.473		NaN											0	0	0	0.01441	0	85	130									
SLC8A1	6546	broad.mit.edu	37	2	40656252	40656252	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:40656252G>A	uc002rrx.2	-	1	1193	c.1169C>T	c.(1168-1170)GCT>GTT	p.A390V	SLC8A1_uc002rry.2_Missense_Mutation_p.A390V|SLC8A1_uc002rrz.2_Missense_Mutation_p.A390V|SLC8A1_uc002rsa.2_Missense_Mutation_p.A390V|SLC8A1_uc002rsd.3_Missense_Mutation_p.A390V|SLC8A1_uc002rsb.1_Missense_Mutation_p.A390V|SLC8A1_uc010fan.1_Missense_Mutation_p.A390V|SLC8A1_uc002rsc.1_Missense_Mutation_p.A390V	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	390	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CATGCTGACAGCCTTCCTTGC	0.453		NaN											0	0	0	0.006214	0	8	15									
CYP26B1	56603	broad.mit.edu	37	2	72371249	72371249	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:72371249C>T	uc002sih.1	-	2	298	c.298G>A	c.(298-300)GAG>AAG	p.E100K	CYP26B1_uc010yra.1_Missense_Mutation_p.E83K|CYP26B1_uc010yrb.1_Intron	NM_019885	NP_063938	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily b,	100					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			skin(2)	2						CGCACGTTCTCCGCGCCGGTC	0.637		NaN											0	0	0	0.012213	0	35	59									
MTHFD2	10797	broad.mit.edu	37	2	74432979	74432979	+	Silent	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:74432979C>G	uc002skk.2	+	2	328	c.249C>G	c.(247-249)TCC>TCG	p.S83S	MTHFD2_uc002skj.2_5'UTR|MTHFD2_uc010yro.1_Intron|MTHFD2_uc010ffb.2_Silent_p.S83S|MTHFD2_uc010yrp.1_Intron	NM_006636	NP_006627	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase 2	83					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding				0					NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CAAGTCACTCCTATGTCCTCA	0.532		NaN											0	0	0	0.01441	0	41	56									
KDM3A	55818	broad.mit.edu	37	2	86669240	86669240	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:86669240G>A	uc002sri.3	+	2	397	c.70G>A	c.(70-72)GAC>AAC	p.D24N	KDM3A_uc010ytj.1_Missense_Mutation_p.D24N|KDM3A_uc010ytk.1_Missense_Mutation_p.D24N	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	24				D -> G (in Ref. 2; CAH18459/CAH18373).	androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						GTCCGCAGCCGACGGCAGCGA	0.642		NaN											0	0	0	0.004289	0	37	50									
EIF2AK3	9451	broad.mit.edu	37	2	88885403	88885403	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:88885403T>C	uc002stc.3	-	9	1808	c.1606A>G	c.(1606-1608)ACA>GCA	p.T536A		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	536	Cytoplasmic (Potential).				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						ATAAACGTTGTTGCTATGATA	0.343		NaN											0	0	0	0.00499	0	14	16									
SEMA4C	54910	broad.mit.edu	37	2	97533612	97533612	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:97533612G>A	uc002sxh.3	-	2	172	c.12C>T	c.(10-12)CAC>CAT	p.H4H	SEMA4C_uc002sxg.3_5'Flank	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	4					muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						AGACAGCCCAGTGTGGGGCCA	0.617		NaN											0	0	0	0.01441	0	61	96									
SULT1C4	27233	broad.mit.edu	37	2	108998923	108998923	+	Silent	SNP	A	A	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:108998923A>T	uc002tea.1	+	3	751	c.378A>T	c.(376-378)CTA>CTT	p.L126L	SULT1C4_uc002tdz.2_3'UTR|SULT1C4_uc010ywr.1_Intron|SULT1C4_uc002teb.1_Intron	NM_006588	NP_006579	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member	126					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity				0						CATCCTTGCTAGAGAAAAACT	0.403		NaN											0	0	0	0.01441	0	102	140									
RANBP2	5903	broad.mit.edu	37	2	109382445	109382445	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:109382445C>T	uc002tem.3	+	20	5576	c.5450C>T	c.(5449-5451)GCT>GTT	p.A1817V		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1817					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						ATTGCAGAAGCTCCTTCAGCT	0.408		NaN											0	0	0	0.001168	0	6	34									
ANAPC1	64682	broad.mit.edu	37	2	112588951	112588951	+	Missense_Mutation	SNP	T	T	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:112588951T>G	uc002thi.2	-	21	2784	c.2537A>C	c.(2536-2538)CAG>CCG	p.Q846P		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	846					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						ACTCACCCACTGATAAATACT	0.383		NaN											0	0	0	0.00278	0	19	32									
MBD5	55777	broad.mit.edu	37	2	149225912	149225912	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:149225912G>C	uc002twm.3	+	9	1388	c.400G>C	c.(400-402)GCA>CCA	p.A134P	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.A134P|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	134						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CACATCAGATGCAACTCCAGT	0.284		NaN											0	0	0	0.009096	0	4	5									
COBLL1	22837	broad.mit.edu	37	2	165551575	165551575	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:165551575G>C	uc010zcw.1	-	15	2766	c.2642C>G	c.(2641-2643)ACT>AGT	p.T881S	COBLL1_uc002ucp.2_Missense_Mutation_p.T814S|COBLL1_uc002ucq.2_Missense_Mutation_p.T776S|COBLL1_uc010zcx.1_Missense_Mutation_p.T822S|COBLL1_uc002ucn.2_Missense_Mutation_p.T242S|COBLL1_uc002uco.2_Missense_Mutation_p.T545S	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	852										ovary(2)|pancreas(1)	3						TTGGATGGCAGTTTCTTTCAC	0.428		NaN											0	0	0	0.00278	0	25	30									
C2orf77	129881	broad.mit.edu	37	2	170505817	170505817	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:170505817C>T	uc002ufe.2	-	8	1286	c.1192G>A	c.(1192-1194)GAG>AAG	p.E398K		NM_001085447	NP_001078916	Q0VFZ6	CB077_HUMAN	hypothetical protein LOC129881	398	Potential.										0						TCTTTAGCCTCTATTTTTCTT	0.343		NaN											0	0	0	0.00245	0	12	30									
SLC25A12	8604	broad.mit.edu	37	2	172669944	172669944	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:172669944C>A	uc002uhh.2	-	11	1165	c.1076G>T	c.(1075-1077)GGC>GTC	p.G359V	SLC25A12_uc010fqh.2_Missense_Mutation_p.G252V	NM_003705	NP_003696	O75746	CMC1_HUMAN	solute carrier family 25, member 12	359	Solcar 1.				gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	AGAGCCAGAGCCACGCTGGTT	0.443		NaN											1	0	3.10996e-30	0.01441	3.6109e-30	43	66									
NFE2L2	4780	broad.mit.edu	37	2	178098945	178098945	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:178098945G>C	uc002ulh.3	-	2	655	c.100C>G	c.(100-102)CGA>GGA	p.R34G	NFE2L2_uc002ulg.3_Missense_Mutation_p.R18G|NFE2L2_uc010zfa.1_Missense_Mutation_p.R18G|NFE2L2_uc002uli.3_Missense_Mutation_p.R18G|NFE2L2_uc010fra.2_Missense_Mutation_p.R18G|NFE2L2_uc010frb.2_Missense_Mutation_p.R18G	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	34					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			AATACTTCTCGACTTACTCCA	0.368		NaN	Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.010729	0	12	15									
NIF3L1	60491	broad.mit.edu	37	2	201761879	201761879	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:201761879A>G	uc002uwm.2	+	5	898	c.807A>G	c.(805-807)ATA>ATG	p.I269M	NIF3L1_uc002uwl.2_Missense_Mutation_p.I242M|NIF3L1_uc002uwn.2_Missense_Mutation_p.I242M|NIF3L1_uc002uwo.2_Missense_Mutation_p.I269M|NIF3L1_uc002uwp.2_Missense_Mutation_p.I269M|NIF3L1_uc002uwq.2_Intron	NM_001136039	NP_001129511	Q9GZT8	NIF3L_HUMAN	NIF3 NGG1 interacting factor 3-like 1 isoform 1	269					positive regulation of transcription, DNA-dependent		transcription factor binding			skin(1)	1						TTGATCGAATAAAAAGACACC	0.428		NaN											0	0	0	0.004289	0	33	45									
NRP2	8828	broad.mit.edu	37	2	206588590	206588590	+	Missense_Mutation	SNP	T	T	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:206588590T>G	uc002vaw.2	+	5	1537	c.746T>G	c.(745-747)TTT>TGT	p.F249C	NRP2_uc002vat.2_Missense_Mutation_p.F249C|NRP2_uc002vau.2_Missense_Mutation_p.F249C|NRP2_uc002vav.2_Missense_Mutation_p.F249C|NRP2_uc002vax.2_Missense_Mutation_p.F249C|NRP2_uc002vay.2_Missense_Mutation_p.F249C|NRP2_uc010fud.2_Missense_Mutation_p.F249C	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	249	Extracellular (Potential).|CUB 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						TCCCTGACCTTTCACACGGAC	0.552		NaN											0	0	0	0.003163	0	15	16									
MDH1B	130752	broad.mit.edu	37	2	207620047	207620047	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:207620047G>A	uc002vbs.2	-	5	651	c.596C>T	c.(595-597)ACG>ATG	p.T199M	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Missense_Mutation_p.T199M|MDH1B_uc010fuj.2_Missense_Mutation_p.T101M|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	199					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		CTCCACCTTCGTGCAGATGGA	0.572		NaN											0	0	0	0.010729	0	10	29									
OBSL1	23363	broad.mit.edu	37	2	220427307	220427307	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:220427307G>A	uc010fwk.2	-	8	2827	c.2770C>T	c.(2770-2772)CGG>TGG	p.R924W	OBSL1_uc010zli.1_5'UTR|OBSL1_uc010fwl.1_Missense_Mutation_p.R399W|OBSL1_uc002vmi.2_Missense_Mutation_p.R924W|OBSL1_uc002vmj.2_Missense_Mutation_p.R511W	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	924	Ig-like 7.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		GCCCAGGGCCGGCATAGCTCA	0.652		NaN											0	0	0	0.001984	0	5	22									
TRIP12	9320	broad.mit.edu	37	2	230650558	230650558	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:230650558C>T	uc002vpw.1	-	33	4893	c.4784G>A	c.(4783-4785)CGA>CAA	p.R1595Q	TRIP12_uc002vpx.1_Missense_Mutation_p.R1643Q|TRIP12_uc002vpy.1_Missense_Mutation_p.R1325Q	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1595					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CAGCTCCTCTCGGTTCACAGT	0.453		NaN											0	0	0	0.008871	0	20	27									
COL6A3	1293	broad.mit.edu	37	2	238305412	238305412	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:238305412G>A	uc002vwl.2	-	2	334	c.49C>T	c.(49-51)CTC>TTC	p.L17F	COL6A3_uc002vwo.2_Missense_Mutation_p.L17F|COL6A3_uc010znj.1_Missense_Mutation_p.L17F|COL6A3_uc002vwq.2_Missense_Mutation_p.L17F|COL6A3_uc002vwr.2_Missense_Mutation_p.L17F|COL6A3_uc010znk.1_Missense_Mutation_p.L17F	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	17					axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AAGCCTGAGAGAAAGAGGCAA	0.413		NaN											0	0	0	0.008291	0	9	56									
RBCK1	10616	broad.mit.edu	37	20	389408	389408	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:389408G>A	uc002wdp.3	+	1	700	c.7G>A	c.(7-9)GAG>AAG	p.E3K	RBCK1_uc010zpl.1_Missense_Mutation_p.E3K|RBCK1_uc010zpm.1_RNA|RBCK1_uc002wdq.3_Missense_Mutation_p.R9Q|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_5'UTR|RBCK1_uc002wdo.2_RNA	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	3	Interaction with IRF3.|Interaction with TAB2.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				CCAGATGGACGAGAAGACCAA	0.682		NaN											0	0	0	0.013537	0	11	8									
SNRPB	6628	broad.mit.edu	37	20	2443347	2443347	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:2443347G>C	uc002wfz.1	-	6	783	c.620C>G	c.(619-621)CCT>CGT	p.P207R	SNRPB_uc002wga.1_Missense_Mutation_p.P207R|SNRPB_uc010zpv.1_Missense_Mutation_p.P128R|SNRPB_uc002wgb.2_Missense_Mutation_p.P207R	NM_198216	NP_937859	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptide B/B'	207	Repeat-rich region.				histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|protein binding|RNA binding			ovary(1)	1						CCCTCTTCCAGGGGGGATCCC	0.587		NaN											0	0	0	0.014323	0	24	80									
INSM1	3642	broad.mit.edu	37	20	20349839	20349839	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:20349839C>G	uc002wrx.2	+	1	1075	c.928C>G	c.(928-930)CTG>GTG	p.L310V		NM_002196	NP_002187	Q01101	INSM1_HUMAN	insulinoma-associated 1	310	C2H2-type 2.				endocrine pancreas development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0649)		CCCGGCCAACCTGGCCTCGCA	0.577		NaN											0	0	0	0.00308	0	7	7									
GDF5	8200	broad.mit.edu	37	20	34022485	34022485	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:34022485C>T	uc002xck.1	-	2	1047	c.728G>A	c.(727-729)CGG>CAG	p.R243Q	GDF5_uc010gfc.1_Missense_Mutation_p.R243Q|uc002xcj.2_Missense_Mutation_p.P299L|GDF5_uc010zvc.1_Missense_Mutation_p.R243Q	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	243					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GGGCTTCTTCCGCAAGATCCG	0.687		NaN											0	0	0	0.008361	0	31	107									
MYBL2	4605	broad.mit.edu	37	20	42320809	42320810	+	Missense_Mutation	DNP	TG	TG	CC			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:42320809_42320810TG>CC	uc002xlb.1	+	6	728_729	c.513_514TG>CC	c.(511-516)GCTGTG>GCCCTG	p.V172L	MYBL2_uc010zwj.1_Missense_Mutation_p.V148L|MYBL2_uc002xla.1_Missense_Mutation_p.V172L	NM_002466	NP_002457	P10244	MYBB_HUMAN	MYB-related protein B	172	HTH myb-type 3.|H-T-H motif (By similarity).					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CAGACAATGCTGTGAAGAATCA	0.337		NaN											0	0	0	0.004672	0	37	52									
WISP2	8839	broad.mit.edu	37	20	43355781	43355781	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:43355781G>A	uc002xmn.2	+	5	939	c.586G>A	c.(586-588)GAA>AAA	p.E196K	uc002xml.1_Intron|uc002xmm.1_Intron|WISP2_uc002xmp.2_Missense_Mutation_p.E196K|WISP2_uc002xmq.2_Silent_p.Q113Q	NM_003881	NP_003872	O76076	WISP2_HUMAN	WNT1 inducible signaling pathway protein 2	196	TSP type-1.				cell adhesion|cell-cell signaling|signal transduction	extracellular region|soluble fraction	insulin-like growth factor binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				CCCCTGCCCAGAATGGAGCAC	0.537		NaN											0	0	0	0.01441	0	45	78									
COL9A3	1299	broad.mit.edu	37	20	61467685	61467685	+	Silent	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:61467685G>C	uc002ydm.2	+	28	1551	c.1548G>C	c.(1546-1548)CCG>CCC	p.P516P	COL9A3_uc002ydn.2_5'Flank	NM_001853	NP_001844	Q14050	CO9A3_HUMAN	alpha 3 type IX collagen precursor	516	Triple-helical region 3 (COL3).				axon guidance	collagen type IX					0	Breast(26;5.68e-08)					CGGGAGTTCCGGTACGTCGCT	0.632		NaN											0	0	0	0.008361	0	27	43									
SLC17A9	63910	broad.mit.edu	37	20	61597892	61597892	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:61597892C>T	uc002yea.3	+	11	1261	c.1077C>T	c.(1075-1077)AAC>AAT	p.N359N	SLC17A9_uc002ydz.3_Silent_p.N353N|SLC17A9_uc011aap.1_Silent_p.N379N	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	359					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						TTTCTGTTAACATCCAGGACT	0.637		NaN											0	0	0	0.004007	0	16	166									
ITSN1	6453	broad.mit.edu	37	21	35147174	35147174	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr21:35147174G>C	uc002yta.1	+	13	1715	c.1447G>C	c.(1447-1449)GAA>CAA	p.E483Q	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.E483Q|ITSN1_uc010gmg.2_Missense_Mutation_p.E446Q|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.E483Q|ITSN1_uc010gmi.2_Missense_Mutation_p.E446Q|ITSN1_uc010gmj.2_Missense_Mutation_p.E367Q|ITSN1_uc002ysy.2_Missense_Mutation_p.E483Q|ITSN1_uc002ysx.2_Missense_Mutation_p.E446Q|ITSN1_uc002ytb.1_Missense_Mutation_p.E483Q|ITSN1_uc002ytc.1_Missense_Mutation_p.E483Q|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.E446Q|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.E483Q|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.E417Q	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	483	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						ATTTGAATTAGAAGCTCTAGT	0.299		NaN											0	0	0	0.001855	0	10	40									
DOPEY2	9980	broad.mit.edu	37	21	37665692	37665692	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr21:37665692C>T	uc002yvg.2	+	37	6799	c.6720C>T	c.(6718-6720)ATC>ATT	p.I2240I	DOPEY2_uc011aeb.1_Silent_p.I2189I	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	2240					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TTTCCAGCATCAGGCAGTTGA	0.458		NaN											0	0	0	0.003954	0	27	29									
DOPEY2	9980	broad.mit.edu	37	21	37665713	37665713	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr21:37665713C>T	uc002yvg.2	+	37	6820	c.6741C>T	c.(6739-6741)TTC>TTT	p.F2247F	DOPEY2_uc011aeb.1_Silent_p.F2196F	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	2247					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TGCCATTCTTCATGACTCTAA	0.478		NaN											0	0	0	0.008361	0	31	33									
BRWD1	54014	broad.mit.edu	37	21	40636520	40636520	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr21:40636520G>T	uc002yxk.1	-	17	1890	c.1751C>A	c.(1750-1752)CCT>CAT	p.P584H	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.P584H|BRWD1_uc010goe.1_Intron|BRWD1_uc010gof.1_Missense_Mutation_p.P37H|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Missense_Mutation_p.P304H	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	584					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CATAAGATGAGGAGCCTGCTG	0.393		NaN											1	0	4.7546e-09	0.004007	5.09317e-09	17	17									
LCA5L	150082	broad.mit.edu	37	21	40783687	40783687	+	Silent	SNP	A	A	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr21:40783687A>G	uc002yxu.2	-	7	1330	c.1017T>C	c.(1015-1017)CAT>CAC	p.H339H	LCA5L_uc002yxv.2_Silent_p.H339H	NM_152505	NP_689718	O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	339											0		Prostate(19;1.2e-06)				TAAGTATTCGATGACTATAGA	0.294		NaN											0	0	0	0.004007	0	14	30									
DNMT3L	29947	broad.mit.edu	37	21	45666349	45666349	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr21:45666349C>T	uc002zeg.1	-	12	1576	c.1092G>A	c.(1090-1092)GTG>GTA	p.V364V	DNMT3L_uc002zeh.1_Silent_p.V365V	NM_175867	NP_787063	Q9UJW3	DNM3L_HUMAN	cytosine-5-methyltransferase 3-like protein	364					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			skin(2)	2				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		AGCAGTTCTTCACCAGCTTGG	0.473		NaN											0	0	0	0.006122	0	18	47									
CACNA1I	8911	broad.mit.edu	37	22	40059831	40059831	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr22:40059831C>G	uc003ayc.2	+	19	3582	c.3582C>G	c.(3580-3582)ATC>ATG	p.I1194M	CACNA1I_uc003ayd.2_Missense_Mutation_p.I1159M|CACNA1I_uc003aye.2_Missense_Mutation_p.I1109M|CACNA1I_uc003ayf.2_Missense_Mutation_p.I1074M	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1194	III.|Extracellular (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GGCCTCAGATCGAGGCCGGCA	0.622		NaN											0	0	0	0.003271	0	30	101									
ENTHD1	150350	broad.mit.edu	37	22	40283688	40283688	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr22:40283688C>G	uc003ayg.2	-	2	316	c.65G>C	c.(64-66)AGG>ACG	p.R22T		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	22	ENTH.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					AGTTGCTTCCCTGACTTTTAT	0.388		NaN											0	0	0	0.003163	0	15	48									
RANGAP1	5905	broad.mit.edu	37	22	41652232	41652232	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr22:41652232C>T	uc003azs.2	-	8	2421	c.951G>A	c.(949-951)ATG>ATA	p.M317I	RANGAP1_uc003azt.2_Missense_Mutation_p.M317I|RANGAP1_uc003azu.2_Missense_Mutation_p.M317I|RANGAP1_uc011aoz.1_Missense_Mutation_p.M262I	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	317	LRR 5.				mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						CTTTGTCTGCCATGGCCTCAG	0.572		NaN											0	0	0	0.01441	0	44	57									
SYN2	6854	broad.mit.edu	37	3	12211351	12211351	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:12211351T>C	uc003bwm.2	+	14	1417	c.1253T>C	c.(1252-1254)CTG>CCG	p.L418P	SYN2_uc003bwl.1_Missense_Mutation_p.L418P|SYN2_uc003bwn.2_Missense_Mutation_p.L92P	NM_133625	NP_598328	Q92777	SYN2_HUMAN	synapsin II isoform IIa	418					neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			ovary(1)|central_nervous_system(1)	2						AACCAGCTGCTGTCCAGGACT	0.542		NaN											0	0	0	0.009096	0	4	15									
TTC21A	199223	broad.mit.edu	37	3	39180207	39180207	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:39180207C>T	uc003cjc.2	+	29	4068	c.3891C>T	c.(3889-3891)CTC>CTT	p.L1297L	TTC21A_uc003cje.2_Silent_p.L1298L|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Silent_p.L1249L|TTC21A_uc003cjf.2_Silent_p.L418L	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	1297	TPR 19.						binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TCCAGGTCCTCAGGGAGCACC	0.587		NaN											0	0	0	0.01441	0	45	25									
ZNF589	51385	broad.mit.edu	37	3	48310197	48310197	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:48310197G>A	uc003csl.3	+	4	1082	c.1016G>A	c.(1015-1017)CGA>CAA	p.R339Q	ZNF589_uc010hjt.1_Missense_Mutation_p.R336Q|ZNF589_uc003csn.2_RNA|ZNF589_uc011bbg.1_Intron|ZNF589_uc003csm.2_Intron	NM_016089	NP_057173	Q86UQ0	ZN589_HUMAN	zinc finger protein 589	339	C2H2-type 4.				regulation of transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000649)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTGTGTGGGCGAGGCTTTCGT	0.502		NaN											0	0	0	0.00499	0	16	84									
COL7A1	1294	broad.mit.edu	37	3	48630366	48630366	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:48630366C>T	uc003ctz.2	-	6	689	c.688G>A	c.(688-690)GAC>AAC	p.D230N		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	230	Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GAGGTCGAGTCATCCGCTGGG	0.587		NaN											0	0	0	0.00308	0	8	15									
CELSR3	1951	broad.mit.edu	37	3	48689917	48689917	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:48689917G>T	uc003cul.2	-	11	5985	c.5704C>A	c.(5704-5706)CCC>ACC	p.P1902T	CELSR3_uc003cuf.1_Missense_Mutation_p.P1972T|CELSR3_uc010hkg.2_5'Flank	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1902	Extracellular (Potential).|Laminin G-like 2.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCACTGCCGGGGGGCAGGCCT	0.637		NaN											1	0	6.42651e-13	0.010729	6.99237e-13	11	40									
QARS	5859	broad.mit.edu	37	3	49141772	49141772	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:49141772C>T	uc003cvx.2	-	2	255	c.250G>A	c.(250-252)GAG>AAG	p.E84K	QARS_uc011bcd.1_5'UTR|QARS_uc003cvy.2_Intron|QARS_uc011bce.1_Intron|QARS_uc011bcf.1_Missense_Mutation_p.E84K	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	84					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	AGCTGGGGCTCAGTGTGGATC	0.562		NaN											0	0	0	0.01441	0	56	42									
AMT	275	broad.mit.edu	37	3	49459597	49459597	+	Silent	SNP	A	A	T	rs151231828		TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:49459597A>T	uc003cww.2	-	2	327	c.198T>A	c.(196-198)ACT>ACA	p.T66T	AMT_uc011bcn.1_Silent_p.T18T|AMT_uc003cwx.2_Silent_p.T66T|AMT_uc011bco.1_Silent_p.T66T|AMT_uc003cwy.2_Silent_p.T18T|AMT_uc011bcp.1_Intron|AMT_uc011bcq.1_Intron	NM_000481	NP_000472	P48728	GCST_HUMAN	aminomethyltransferase isoform 1 precursor	66					glycine catabolic process	mitochondrion	aminomethyltransferase activity|transaminase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	GGTGCGAGTCAGTGTGACTGT	0.607		NaN											0	0	0	0.007413	0	18	75									
PBRM1	55193	broad.mit.edu	37	3	52597459	52597459	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:52597459A>G	uc003des.2	-	24	3938	c.3926T>C	c.(3925-3927)ATC>ACC	p.I1309T	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.I1309T|PBRM1_uc003der.2_Missense_Mutation_p.I1277T|PBRM1_uc003det.2_Missense_Mutation_p.I1324T|PBRM1_uc003deu.2_Missense_Mutation_p.I1324T|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.I1309T|PBRM1_uc010hmk.1_Missense_Mutation_p.I1284T|PBRM1_uc003dey.2_Missense_Mutation_p.I1284T|PBRM1_uc003dez.1_Missense_Mutation_p.I1308T	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1309					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TAGCAACTGGATCTTCTTTTC	0.403		NaN	Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	0.006122	0	16	60									
FLNB	2317	broad.mit.edu	37	3	58111396	58111396	+	Silent	SNP	T	T	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:58111396T>C	uc003djj.2	+	23	4152	c.3987T>C	c.(3985-3987)TCT>TCC	p.S1329S	FLNB_uc010hne.2_Silent_p.S1329S|FLNB_uc003djk.2_Silent_p.S1329S|FLNB_uc010hnf.2_Silent_p.S1329S|FLNB_uc003djl.2_Silent_p.S1160S|FLNB_uc003djm.2_Silent_p.S1160S	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1329	Filamin 12.|Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GCCAGCCATCTAGGGTGCAAG	0.522		NaN											0	0	0	0.01441	0	54	44									
DZIP3	9666	broad.mit.edu	37	3	108407451	108407451	+	Silent	SNP	A	A	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:108407451A>G	uc003dxd.2	+	30	3704	c.3282A>G	c.(3280-3282)AAA>AAG	p.K1094K	DZIP3_uc003dxf.1_Silent_p.K1094K|DZIP3_uc011bhm.1_Silent_p.K545K	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	1094					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTCAAGGAAAATCAGTGTCAA	0.403		NaN											0	0	0	0.006122	0	19	24									
SEMA5B	54437	broad.mit.edu	37	3	122631022	122631022	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:122631022G>A	uc003efz.1	-	19	3197	c.2893C>T	c.(2893-2895)CCA>TCA	p.P965S	SEMA5B_uc011bju.1_Missense_Mutation_p.P871S|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.P965S|SEMA5B_uc003efy.1_Intron	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	965	Extracellular (Potential).|TSP type-1 4.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CTCATACCTGGGCAGGCCTGT	0.642		NaN											0	0	0	0.010729	0	11	13									
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	T	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:126707544T>G	uc003ejg.2	+	1	43	c.39T>G	c.(37-39)GGT>GGG	p.G13G		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	36	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.567		NaN											0	0	0	0.005443	0	8	30									
RAB43	339122	broad.mit.edu	37	3	128852989	128852989	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:128852989C>T	uc003elo.1	-	9	802	c.591G>A	c.(589-591)CTG>CTA	p.L197L	ISY1_uc010hsz.1_Intron|ISY1_uc003elp.1_Silent_p.L197L|ISY1_uc010hta.1_Silent_p.L219L	NM_020701	NP_065752	Q86YS6	RAB43_HUMAN	ISY1 splicing factor homolog	Error:Variant_position_missing_in_Q86YS6_after_alignment					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			lung(1)	1						CTCCTCTTGCCAGCCGAGCCT	0.428		NaN											0	0	0	0.001855	0	11	88									
NAALADL2	254827	broad.mit.edu	37	3	175184817	175184817	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:175184817G>A	uc003fit.2	+	8	1465	c.1378G>A	c.(1378-1380)GGA>AGA	p.G460R	NAALADL2_uc003fiu.1_Missense_Mutation_p.G453R|NAALADL2_uc010hwy.1_Missense_Mutation_p.G234R|NAALADL2_uc010hwz.1_Missense_Mutation_p.G54R	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	460	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		CAGTTATAATGGACAAGAATG	0.403		NaN											0	0	0	0.01441	0	61	142									
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.001984	0	7	13									
MFN1	55669	broad.mit.edu	37	3	179085314	179085314	+	Missense_Mutation	SNP	T	T	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:179085314T>G	uc003fjs.2	+	8	967	c.841T>G	c.(841-843)TTC>GTC	p.F281V	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.F309V|MFN1_uc010hxc.2_Missense_Mutation_p.F134V	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	281	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			GAATCGTATCTTCTTTGTTTC	0.403		NaN											0	0	0	0.008361	0	30	18									
FGF12	2257	broad.mit.edu	37	3	191888334	191888334	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:191888334C>A	uc003fsx.2	-	4	1352	c.526G>T	c.(526-528)GGA>TGA	p.G176*	FGF12_uc003fsy.2_Nonsense_Mutation_p.G114*	NM_021032	NP_066360	P61328	FGF12_HUMAN	fibroblast growth factor 12 isoform 1	176					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		TTATTGAGTCCCAGAAACCAA	0.413		NaN											1	0	1.45844e-13	0.013726	1.60196e-13	31	137									
PIGG	54872	broad.mit.edu	37	4	509942	509942	+	Missense_Mutation	SNP	T	T	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:509942T>A	uc003gak.3	+	6	1218	c.1082T>A	c.(1081-1083)CTG>CAG	p.L361Q	PIGG_uc003gaj.3_Missense_Mutation_p.L361Q|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Missense_Mutation_p.L228Q|PIGG_uc003gal.3_Missense_Mutation_p.L272Q|PIGG_uc003gai.2_RNA|PIGG_uc011buw.1_Missense_Mutation_p.L239Q|PIGG_uc003gam.2_Missense_Mutation_p.L272Q|PIGG_uc003gan.2_Missense_Mutation_p.L272Q	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	361	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						CTTAGTAAACTGTTGCAAGAG	0.453		NaN											0	0	0	0.00874	0	42	55									
DGKQ	1609	broad.mit.edu	37	4	955317	955317	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:955317C>T	uc003gbw.2	-	21	2586	c.2512G>A	c.(2512-2514)GAG>AAG	p.E838K	DGKQ_uc010ibn.2_Missense_Mutation_p.E825K	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	838					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CGTGGCTTCTCAAACCTGGTG	0.701		NaN											0	0	0	0.008291	0	9	12									
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.004007	0	10	17									
JAKMIP1	152789	broad.mit.edu	37	4	6114541	6114541	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:6114541C>T	uc003giu.3	-	2	313	c.37G>A	c.(37-39)GAG>AAG	p.E13K	JAKMIP1_uc010idb.1_Missense_Mutation_p.E13K|JAKMIP1_uc010idc.1_Missense_Mutation_p.E13K|JAKMIP1_uc010idd.1_Missense_Mutation_p.E13K|JAKMIP1_uc011bwc.1_Missense_Mutation_p.E13K|JAKMIP1_uc003giv.3_Missense_Mutation_p.E13K|JAKMIP1_uc010ide.2_Missense_Mutation_p.E13K	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	13	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						GTCTCCATCTCGGGCTTCTCG	0.612		NaN											0	0	0	0.00278	0	22	62									
NCAPG	64151	broad.mit.edu	37	4	17816575	17816575	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:17816575G>T	uc003gpp.2	+	4	820	c.644G>T	c.(643-645)GGG>GTG	p.G215V	NCAPG_uc011bxj.1_5'UTR	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	215					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		AAAATTGTAGGGCGCACCAAG	0.403		NaN											1	0	4.00102e-26	0.00623	4.59918e-26	36	47									
KDR	3791	broad.mit.edu	37	4	55970921	55970921	+	Missense_Mutation	SNP	T	T	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:55970921T>C	uc003has.2	-	13	2178	c.1876A>G	c.(1876-1878)ATC>GTC	p.I626V	KDR_uc003hat.1_Missense_Mutation_p.I626V|KDR_uc011bzx.1_Missense_Mutation_p.I626V	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	626	Ig-like C2-type 6.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AGCTCCATGATCAAAATGTCA	0.448		NaN	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	0.004672	0	3	25									
PROL1	58503	broad.mit.edu	37	4	71275374	71275374	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:71275374G>C	uc003hfi.2	+	3	503	c.329G>C	c.(328-330)AGA>ACA	p.R110T		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	110	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				TTCCCACTAAGACCTTACTAT	0.403		NaN											0	0	0	0.010818	0	26	120									
ADAMTS3	9508	broad.mit.edu	37	4	73186565	73186565	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:73186565C>T	uc003hgk.1	-	7	1005	c.968G>A	c.(967-969)GGA>GAA	p.G323E		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	323	Peptidase M12B.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GGATGGGTTTCCCCTTTCTAT	0.428		NaN											0	0	0	0.001168	0	5	16									
RASGEF1B	153020	broad.mit.edu	37	4	82362031	82362031	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:82362031C>T	uc003hmi.1	-	10	1205	c.1061G>A	c.(1060-1062)GGG>GAG	p.G354E	RASGEF1B_uc003hmj.1_Missense_Mutation_p.G353E|RASGEF1B_uc010ijq.1_Missense_Mutation_p.G312E	NM_152545	NP_689758	Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	354	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						TTGTGCTGCCCCACGAAGAGC	0.338		NaN											0	0	0	0.01441	0	43	56									
GAR1	54433	broad.mit.edu	37	4	110740212	110740212	+	Missense_Mutation	SNP	A	A	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:110740212A>T	uc003hzt.2	+	4	732	c.425A>T	c.(424-426)CAG>CTG	p.Q142L	GAR1_uc003hzu.2_Missense_Mutation_p.Q142L|GAR1_uc010imh.1_Missense_Mutation_p.Q142L|GAR1_uc010imi.2_Missense_Mutation_p.Q142L	NM_018983	NP_061856	Q9NY12	GAR1_HUMAN	nucleolar protein family A, member 1	142					rRNA processing|snRNA pseudouridine synthesis	box H/ACA snoRNP complex|Cajal body	cation channel activity|pseudouridine synthase activity|snoRNA binding				0						AAAAAACTACAGAAGGTGAGT	0.343		NaN											0	0	0	0.013726	0	30	40									
LRIT3	345193	broad.mit.edu	37	4	110789062	110789062	+	Silent	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:110789062C>A	uc003hzx.3	+	2	913	c.720C>A	c.(718-720)ATC>ATA	p.I240I	LRIT3_uc003hzw.3_Silent_p.I102I	NM_198506	NP_940908	Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and	240	Ig-like.					integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		CCCCACAGATCACATGGACCA	0.453		NaN											1	0	0.00198382	0.001984	0.00203077	5	37									
SLC9A3	6550	broad.mit.edu	37	5	476428	476428	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:476428G>A	uc003jbe.2	-	13	2068	c.1956C>T	c.(1954-1956)ATC>ATT	p.I652I	SLC9A3_uc011clx.1_Silent_p.I643I|uc011cly.1_5'Flank	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	652	Interaction with PDZD3 (By similarity).|Cytoplasmic (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			TCCTGTGGAAGATTTCCCGGT	0.607		NaN											0	0	0	0.01441	0	64	19									
CTNND2	1501	broad.mit.edu	37	5	11022943	11022943	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:11022943C>T	uc003jfa.1	-	17	3082	c.2937G>A	c.(2935-2937)AAG>AAA	p.K979K	CTNND2_uc010itt.2_Silent_p.K888K|CTNND2_uc011cmy.1_Silent_p.K642K|CTNND2_uc011cmz.1_Silent_p.K546K|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.K571K	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	979	ARM 9.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CCCGTAAGGCCTTGGCGTTCT	0.512		NaN											0	0	0	0.008291	0	9	28									
HCN1	348980	broad.mit.edu	37	5	45645317	45645317	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:45645317C>A	uc003jok.2	-	2	844	c.819G>T	c.(817-819)AGG>AGT	p.R273S		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	273	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						ATCTAATTAACCTTGAAAGTC	0.328		NaN											1	0	0.00116845	0.001168	0.00119965	6	2									
PLK2	10769	broad.mit.edu	37	5	57755666	57755666	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:57755666C>T	uc003jrn.2	-	1	248	c.121G>A	c.(121-123)GAA>AAA	p.E41K	PLK2_uc011cql.1_5'Flank	NM_006622	NP_006613	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	41					positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		GGCTGCGATTCCTCGGGGGGC	0.677		NaN											0	0	0	0.008871	0	19	7									
C5orf44	80006	broad.mit.edu	37	5	64920912	64920912	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:64920912G>C	uc003jtz.3	+	1	355	c.25G>C	c.(25-27)GAG>CAG	p.E9Q	TRIM23_uc003jtw.2_5'Flank|TRIM23_uc003jtx.2_5'Flank|TRIM23_uc003jty.2_5'Flank|C5orf44_uc010iwu.1_5'UTR|C5orf44_uc003jua.3_Missense_Mutation_p.E9Q|C5orf44_uc003juc.3_Missense_Mutation_p.E9Q|C5orf44_uc010iwv.2_Missense_Mutation_p.E9Q	NM_024941	NP_079217	A5PLN9	CE044_HUMAN	hypothetical protein LOC80006 isoform 2	9										ovary(1)	1						CCCTAAACAGGAGCACCTGCT	0.512		NaN											0	0	0	0.00499	0	14	7									
CAST	831	broad.mit.edu	37	5	96100940	96100940	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:96100940C>A	uc003klz.1	+	24	1861	c.1699C>A	c.(1699-1701)CTC>ATC	p.L567I	CAST_uc003klt.2_Missense_Mutation_p.L554I|CAST_uc003klu.2_Missense_Mutation_p.L650I|CAST_uc003klv.2_Missense_Mutation_p.L628I|CAST_uc003klw.2_Missense_Mutation_p.L631I|CAST_uc003klx.2_Missense_Mutation_p.L609I|CAST_uc003kly.2_Missense_Mutation_p.L615I|CAST_uc011cuo.1_Missense_Mutation_p.L613I|CAST_uc011cur.1_Missense_Mutation_p.L553I|CAST_uc011cus.1_Missense_Mutation_p.L554I|CAST_uc003kma.1_Missense_Mutation_p.L525I|CAST_uc011cut.1_Missense_Mutation_p.L495I|CAST_uc003kmb.2_Missense_Mutation_p.L513I|CAST_uc003kmc.2_Missense_Mutation_p.L567I|CAST_uc003kmd.2_Missense_Mutation_p.L545I|CAST_uc003kme.2_Missense_Mutation_p.L526I|CAST_uc003kmf.2_Missense_Mutation_p.L532I|CAST_uc003kmh.2_Missense_Mutation_p.L281I|CAST_uc010jbj.2_Missense_Mutation_p.L282I|CAST_uc010jbk.2_Missense_Mutation_p.L282I|CAST_uc010jbl.1_Missense_Mutation_p.L290I|CAST_uc003kmi.2_RNA|CAST_uc003kmj.2_Missense_Mutation_p.L289I|CAST_uc003kmk.2_RNA|ERAP1_uc003kml.2_Intron	NM_001042443	NP_001035908	P20810	ICAL_HUMAN	calpastatin isoform i	567							calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(3)|ovary(1)|kidney(1)	5		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		TGACAAAGACCTCGATGATGC	0.403		NaN											1	0	1.15088e-07	0.004007	1.22902e-07	17	8									
PCDHA6	56142	broad.mit.edu	37	5	140209959	140209959	+	Silent	SNP	G	G	A	rs150255684	byFrequency	TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:140209959G>A	uc003lho.2	+	1	2310	c.2283G>A	c.(2281-2283)GGG>GGA	p.G761G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.G761G	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	761	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGCTCCGGGGAGGGCCCAC	0.607		NaN											0	0	0	0.008291	0	11	44									
FAT2	2196	broad.mit.edu	37	5	150946090	150946090	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:150946090G>A	uc003lue.3	-	1	2416	c.2403C>T	c.(2401-2403)TCC>TCT	p.S801S	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Silent_p.S801S	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	801	Extracellular (Potential).|Cadherin 6.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTTCCAGGAGGACTTCTGGG	0.512		NaN											0	0	0	0.01441	0	46	10									
DOCK2	1794	broad.mit.edu	37	5	169477279	169477279	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:169477279G>T	uc003maf.2	+	41	4171	c.4091G>T	c.(4090-4092)CGC>CTC	p.R1364L	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.R856L	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1364	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTCATCTACCGCGGGAAGGAA	0.502		NaN											1	0	1.42033e-22	0.004289	1.606e-22	35	70									
SLC22A23	63027	broad.mit.edu	37	6	3284172	3284172	+	Silent	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:3284172C>A	uc003mvm.3	-	9	1617	c.1617G>T	c.(1615-1617)GCG>GCT	p.A539A	uc003mvi.1_Intron|SLC22A23_uc003mvn.3_Silent_p.A258A|SLC22A23_uc003mvo.3_Silent_p.A258A|SLC22A23_uc003mvp.1_RNA|SLC22A23_uc010jnn.2_Silent_p.A539A	NM_015482	NP_056297	A1A5C7	S22AN_HUMAN	solute carrier family 22, member 23 isoform a	539	Helical; (Potential).				ion transport	integral to membrane	transmembrane transporter activity			ovary(1)	1	Ovarian(93;0.0493)	all_hematologic(90;0.0905)				CGATGGAAAACGCGATGGAAA	0.587		NaN											1	0	9.31168e-06	0.001855	9.73366e-06	14	22									
RREB1	6239	broad.mit.edu	37	6	7230402	7230402	+	Silent	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:7230402G>T	uc003mxc.2	+	10	2460	c.2070G>T	c.(2068-2070)CTG>CTT	p.L690L	RREB1_uc003mxb.2_Silent_p.L690L|RREB1_uc010jnx.2_Silent_p.L690L	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	690	C2H2-type 8.				multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				TCCGCCACCTGCGCACGCACA	0.627		NaN											1	0	8.60227e-14	0.004007	9.47894e-14	17	39									
HLA-A	3105	broad.mit.edu	37	6	29910693	29910693	+	Missense_Mutation	SNP	A	A	G	rs41559716		TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:29910693A>G	uc003nol.2	+	2	233	c.233A>G	c.(232-234)CAG>CGG	p.Q78R	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Missense_Mutation_p.Q78R|HLA-A_uc003noo.2_Missense_Mutation_p.Q78R|HLA-A_uc010jrr.2_Missense_Mutation_p.Q78R|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_Missense_Mutation_p.Q50R|HLA-A_uc011dmc.1_5'UTR|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	78	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TGGATAGAGCAGGAGGGGCCG	0.657		NaN							Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			0	0	0	0.00308	0	4	33									
TRERF1	55809	broad.mit.edu	37	6	42231063	42231063	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:42231063C>G	uc003osd.2	-	8	2442	c.1879G>C	c.(1879-1881)GTG>CTG	p.V627L	TRERF1_uc011duq.1_Intron|TRERF1_uc003osb.2_Intron|TRERF1_uc003osc.2_Intron|TRERF1_uc003ose.2_Missense_Mutation_p.V627L	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	627	Pro-rich.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTCACGAGCACAGGCATCTCG	0.682		NaN											0	0	0	0.003755	0	31	80									
UBR2	23304	broad.mit.edu	37	6	42625826	42625826	+	Silent	SNP	T	T	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:42625826T>G	uc011dur.1	+	27	2937	c.2937T>G	c.(2935-2937)GCT>GCG	p.A979A	UBR2_uc011dus.1_Silent_p.A624A|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	979					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			TACAAAATGCTCCCTACCTAG	0.373		NaN											0	0	0	0.01441	0	56	73									
CUL7	9820	broad.mit.edu	37	6	43008026	43008026	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:43008026C>T	uc003otq.2	-	22	4465	c.4162G>A	c.(4162-4164)GAA>AAA	p.E1388K	CUL7_uc010jyg.2_Missense_Mutation_p.E667K|CUL7_uc011dvb.1_Missense_Mutation_p.E1472K|CUL7_uc010jyh.2_Missense_Mutation_p.E381K|KLC4_uc003otr.1_5'Flank	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1388					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			ACAGACACTTCTGGCATTGCC	0.498		NaN											0	0	0	0.008361	0	32	42									
TDRD6	221400	broad.mit.edu	37	6	46656613	46656613	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:46656613G>A	uc003oyj.2	+	1	748	c.748G>A	c.(748-750)GTG>ATG	p.V250M	TDRD6_uc010jze.2_Missense_Mutation_p.V244M	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	250					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GCAGCTGGGCGTGACGGAGGC	0.632		NaN											0	0	0	0.007413	0	20	22									
TDRD6	221400	broad.mit.edu	37	6	46661470	46661470	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:46661470C>G	uc003oyj.2	+	1	5605	c.5605C>G	c.(5605-5607)CTA>GTA	p.L1869V	TDRD6_uc010jze.2_Missense_Mutation_p.L1863V	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1869					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AAAAGGGGAGCTAAGCCCGGT	0.478		NaN											0	0	0	0.00308	0	8	43									
AKD1	221264	broad.mit.edu	37	6	109854548	109854548	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:109854548C>A	uc003ptn.2	-	28	3553	c.3476G>T	c.(3475-3477)CGC>CTC	p.R1159L	AKD1_uc011eat.1_Missense_Mutation_p.R238L	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	1159					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						AGGAAGGAGGCGATCAAAAAT	0.383		NaN											1	0	0.004672	0.004672	0.00475445	3	15									
CLVS2	134829	broad.mit.edu	37	6	123319132	123319132	+	Silent	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:123319132C>G	uc003pzi.1	+	2	1079	c.210C>G	c.(208-210)CGC>CGG	p.R70R		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	70					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						AGGCCTTCCGCCTCCTGGCGC	0.547		NaN											0	0	0	0.013726	0	28	51									
UTRN	7402	broad.mit.edu	37	6	144613024	144613024	+	Silent	SNP	T	T	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:144613024T>C	uc003qkt.2	+	1	152	c.60T>C	c.(58-60)GAT>GAC	p.D20D	UTRN_uc010khq.1_Silent_p.D20D	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	20	Actin-binding.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AATTCAGTGATATCATTAAGT	0.378		NaN											0	0	0	0.010504	0	19	11									
ZBTB2	57621	broad.mit.edu	37	6	151687920	151687920	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:151687920C>T	uc003qoh.2	-	3	416	c.281G>A	c.(280-282)CGA>CAA	p.R94Q		NM_020861	NP_065912	Q8N680	ZBTB2_HUMAN	zinc finger and BTB domain containing 2	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.63e-11)		CTGTTCTAATCGAACCGGGTC	0.537		NaN											0	0	0	0.01441	0	59	18									
WTAP	9589	broad.mit.edu	37	6	160169296	160169296	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:160169296C>T	uc003qsl.2	+	6	569	c.347C>T	c.(346-348)GCG>GTG	p.A116V	WTAP_uc010kjx.2_Missense_Mutation_p.A116V|WTAP_uc003qsk.2_Missense_Mutation_p.A116V|WTAP_uc003qsm.1_RNA|WTAP_uc003qsn.2_Missense_Mutation_p.A116V	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1	116					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		GTAGACCCAGCGATCAACTTG	0.443		NaN											0	0	0	0.008291	0	11	8									
TTLL2	83887	broad.mit.edu	37	6	167755014	167755014	+	Silent	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:167755014G>C	uc003qvs.1	+	3	1714	c.1626G>C	c.(1624-1626)CTG>CTC	p.L542L	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	542					protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CGTGTGTCCTGTCAGACCGTG	0.532		NaN											0	0	0	0.004289	0	32	14									
SMOC2	64094	broad.mit.edu	37	6	169051454	169051454	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:169051454C>T	uc003qws.1	+	10	1021	c.1001C>T	c.(1000-1002)TCG>TTG	p.S334L	SMOC2_uc003qwr.1_Missense_Mutation_p.S345L|SMOC2_uc011egu.1_Missense_Mutation_p.S11L	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	334					signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		CCCTCCTCCTCGTCAGGCAGG	0.557		NaN											0	0	0	0.00308	0	8	2									
PRKAR1B	5575	broad.mit.edu	37	7	624145	624145	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:624145C>G	uc003siu.1	-	9	875	c.769G>C	c.(769-771)GAG>CAG	p.E257Q	PRKAR1B_uc003siv.2_Missense_Mutation_p.E257Q|PRKAR1B_uc003siw.1_Missense_Mutation_p.E257Q|PRKAR1B_uc003six.1_RNA	NM_002735	NP_002726	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type	257	cAMP 2.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		AGCCACTGACCTAGGATGGAG	0.592		NaN											0	0	0	0.008291	0	10	17									
IGF2BP3	10643	broad.mit.edu	37	7	23390927	23390927	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:23390927G>C	uc003swg.2	-	6	946	c.680C>G	c.(679-681)TCT>TGT	p.S227C		NM_006547	NP_006538	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding	227	KH 1.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			ovary(2)	2						TACTCACTTAGACTGGGTCTG	0.488		NaN											0	0	0	0.006122	0	17	60									
OSBPL3	26031	broad.mit.edu	37	7	24911680	24911680	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:24911680C>G	uc003sxf.2	-	3	510	c.105G>C	c.(103-105)TGG>TGC	p.W35C	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.W35C|OSBPL3_uc003sxh.2_Missense_Mutation_p.W35C|OSBPL3_uc003sxi.2_Missense_Mutation_p.W35C	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	35					lipid transport		lipid binding|protein binding			skin(1)	1						CCACCACTTCCCAGCTGTCCT	0.403		NaN											0	0	0	0.003163	0	12	37									
EGFR	1956	broad.mit.edu	37	7	55224469	55224469	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:55224469C>G	uc003tqk.2	+	10	1397	c.1151C>G	c.(1150-1152)ACT>AGT	p.T384S	EGFR_uc003tqh.2_Missense_Mutation_p.T384S|EGFR_uc003tqi.2_Missense_Mutation_p.T384S|EGFR_uc003tqj.2_Missense_Mutation_p.T384S|EGFR_uc010kzg.1_Missense_Mutation_p.T339S|EGFR_uc011kco.1_Missense_Mutation_p.T331S|EGFR_uc011kcp.1_RNA|EGFR_uc011kcq.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	384	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TTCACACATACTCCTCCTCTG	0.373		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			0	0	0	0.007413	0	18	85									
LANCL2	55915	broad.mit.edu	37	7	55468950	55468950	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:55468950G>C	uc003tqp.2	+	5	1340	c.762G>C	c.(760-762)TGG>TGC	p.W254C		NM_018697	NP_061167	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2	254					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			ovary(1)|skin(1)	2	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			TGTACCAGTGGCACCGGAAGC	0.438		NaN											0	0	0	0.01441	0	45	55									
GNAI1	2770	broad.mit.edu	37	7	79846687	79846687	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:79846687G>A	uc003uhb.1	+	8	1280	c.943G>A	c.(943-945)GAC>AAC	p.D315N	GNAI1_uc011kgt.1_Missense_Mutation_p.D263N	NM_002069	NP_002060	P63096	GNAI1_HUMAN	guanine nucleotide binding protein (G protein),	315					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody|nucleus	G-protein beta/gamma-subunit complex binding|GTP binding|metabotropic serotonin receptor binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TAAAAGAAAGGACACAAAGGA	0.348		NaN											0	0	0	0.013537	0	12	24									
MUC17	140453	broad.mit.edu	37	7	100685857	100685857	+	Silent	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:100685857C>G	uc003uxp.1	+	3	11213	c.11160C>G	c.(11158-11160)GTC>GTG	p.V3720V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3720	Extracellular (Potential).|59.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTTCTGTTGTCACCAGCACAC	0.507		NaN											0	0	0	0.01441	0	80	106									
PARP12	64761	broad.mit.edu	37	7	139724424	139724424	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:139724424G>T	uc003vvl.1	-	12	2916	c.2042C>A	c.(2041-2043)TCC>TAC	p.S681Y	PARP12_uc003vvk.1_Missense_Mutation_p.S467Y|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	681	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					CGAGGGCTTGGAGGAGGTGGT	0.562		NaN											1	0	7.93312e-07	0.00245	8.34304e-07	14	50									
TRPV6	55503	broad.mit.edu	37	7	142575431	142575431	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:142575431C>T	uc003wbx.1	-	3	538	c.322G>A	c.(322-324)GAG>AAG	p.E108K	TRPV6_uc003wbw.1_5'Flank|TRPV6_uc010lou.1_5'UTR	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	108	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					GTCATGGGCTCAAAGACCAGC	0.587		NaN											0	0	0	0.01441	0	58	76									
OR6B1	135946	broad.mit.edu	37	7	143701527	143701527	+	Silent	SNP	T	T	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:143701527T>A	uc003wdt.1	+	1	438	c.438T>A	c.(436-438)CTT>CTA	p.L146L		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					GCCTCGCTCTTGGTTCCTGGG	0.562		NaN											0	0	0	0.013537	0	12	29									
MTUS1	57509	broad.mit.edu	37	8	17573306	17573306	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:17573306G>C	uc003wxv.2	-	5	3028	c.2554C>G	c.(2554-2556)CAT>GAT	p.H852D	MTUS1_uc003wxt.2_Missense_Mutation_p.H99D|MTUS1_uc011kyg.1_5'UTR|MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.H798D	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	852						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		AAGTGAACATGAGCCCTGGAT	0.428		NaN											0	0	0	0.004289	0	35	142									
FGL1	2267	broad.mit.edu	37	8	17739539	17739539	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:17739539G>A	uc003wxx.2	-	4	537	c.213C>T	c.(211-213)GTC>GTT	p.V71V	FGL1_uc003wxy.2_Silent_p.V71V|FGL1_uc003wxz.2_Silent_p.V71V|FGL1_uc003wya.2_Silent_p.V71V|FGL1_uc003wyb.2_Silent_p.V71V|FGL1_uc003wyc.2_Silent_p.V71V|FGL1_uc003wyd.2_RNA|FGL1_uc003wye.2_Silent_p.V121V|FGL1_uc003wyf.2_Silent_p.V41V	NM_201553	NP_963847	Q08830	FGL1_HUMAN	fibrinogen-like 1 precursor	71					signal transduction	fibrinogen complex	receptor binding				0				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		CAAGATCAATGACAGTATTCT	0.438		NaN											0	0	0	0.013114	0	45	52									
FZD3	7976	broad.mit.edu	37	8	28378298	28378298	+	Silent	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:28378298G>A	uc003xgx.2	+	4	811	c.333G>A	c.(331-333)TCG>TCA	p.S111S	FZD3_uc010lvb.2_Silent_p.S111S	NM_017412	NP_059108	Q9NPG1	FZD3_HUMAN	frizzled 3 precursor	111	FZ.|Extracellular (Potential).				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		GTGAGTGTTCGAAGCTCATGG	0.443		NaN											0	0	0	0.003755	0	36	102									
MYST3	7994	broad.mit.edu	37	8	41792359	41792359	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:41792359G>C	uc010lxb.2	-	18	3923	c.3379C>G	c.(3379-3381)CTT>GTT	p.L1127V	MYST3_uc010lxc.2_Missense_Mutation_p.L1127V|MYST3_uc003xon.3_Missense_Mutation_p.L1127V	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1127					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TTTCGCAAAAGAGATACTGGC	0.413		NaN											0	0	0	0.01441	0	51	245									
IKBKB	3551	broad.mit.edu	37	8	42174385	42174385	+	Missense_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:42174385C>G	uc003xow.1	+	11	1265	c.1088C>G	c.(1087-1089)CCC>CGC	p.P363R	IKBKB_uc003xov.2_Missense_Mutation_p.P363R|IKBKB_uc010lxh.1_Missense_Mutation_p.P258R|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.P140R|IKBKB_uc003xox.1_Missense_Mutation_p.P84R|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.P361R|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.P304R	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	363					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	GCGTTGATCCCCGATAAGCCT	0.577		NaN											0	0	0	0.004482	0	8	38									
KIAA0146	23514	broad.mit.edu	37	8	48614292	48614292	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:48614292C>T	uc003xqd.2	+	13	1792	c.1783C>T	c.(1783-1785)CAT>TAT	p.H595Y	KIAA0146_uc011ldb.1_Missense_Mutation_p.H595Y|KIAA0146_uc010lxs.2_Missense_Mutation_p.H70Y|KIAA0146_uc011ldc.1_Missense_Mutation_p.H525Y|KIAA0146_uc011ldd.1_Missense_Mutation_p.H535Y|KIAA0146_uc003xqe.2_Missense_Mutation_p.H70Y|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Missense_Mutation_p.H284Y|KIAA0146_uc010lxt.2_Missense_Mutation_p.H284Y|KIAA0146_uc011ldf.1_Missense_Mutation_p.H100Y|KIAA0146_uc011ldg.1_Missense_Mutation_p.H85Y|KIAA0146_uc010lxv.1_Missense_Mutation_p.H89Y	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	595											0		Lung NSC(58;0.175)				GATAAAAACTCATCTGCCTCC	0.353		NaN											0	0	0	0.01441	0	74	108									
MCM4	4173	broad.mit.edu	37	8	48875509	48875509	+	Missense_Mutation	SNP	A	A	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:48875509A>G	uc003xqk.1	+	7	697	c.602A>G	c.(601-603)AAT>AGT	p.N201S	PRKDC_uc003xqi.2_5'Flank|PRKDC_uc003xqj.2_5'Flank|PRKDC_uc011ldh.1_5'Flank|MCM4_uc003xql.1_Missense_Mutation_p.N201S|MCM4_uc011ldi.1_Missense_Mutation_p.N188S|MCM4_uc010lxw.1_RNA	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	201					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				TTCTAGATTAATGTTATTGGT	0.284		NaN											0	0	0	0.010818	0	34	33									
FER1L6	654463	broad.mit.edu	37	8	125015463	125015463	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:125015463G>A	uc003yqw.2	+	13	1782	c.1576G>A	c.(1576-1578)GAA>AAA	p.E526K	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	526	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GAAGTCAGCTGAATCAGCTGA	0.522		NaN											0	0	0	0.00333	0	22	41									
FER1L6	654463	broad.mit.edu	37	8	125015577	125015577	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:125015577G>C	uc003yqw.2	+	13	1896	c.1690G>C	c.(1690-1692)GAA>CAA	p.E564Q	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	564	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ACTGGTGACAGAAGGGAACAG	0.507		NaN											0	0	0	0.009096	0	2	16									
TSTA3	7264	broad.mit.edu	37	8	144696593	144696593	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:144696593G>T	uc003yza.2	-	6	531	c.495C>A	c.(493-495)TTC>TTA	p.F165L	TSTA3_uc003yzb.2_Missense_Mutation_p.F165L	NM_003313	NP_003304	Q13630	FCL_HUMAN	tissue specific transplantation antigen P35B	165					'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			pancreas(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)	TGACAGCGGTGAAGGTGCAGC	0.662		NaN											1	0	0.00116845	0.001168	0.00119965	5	53									
MUSK	4593	broad.mit.edu	37	9	113496648	113496648	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr9:113496648G>A	uc004bey.2	+	6	844	c.746G>A	c.(745-747)GGA>GAA	p.G249E	MUSK_uc004bex.2_Missense_Mutation_p.G259E	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	249	Ig-like 3.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						ATTGAAAACGGAAATGCTGTG	0.507		NaN											0	0	0	0.010504	0	20	4									
PRPF4	9128	broad.mit.edu	37	9	116053237	116053237	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr9:116053237G>T	uc004bgx.2	+	13	1366	c.1316G>T	c.(1315-1317)CGG>CTG	p.R439L	PRPF4_uc004bgy.2_Missense_Mutation_p.R438L	NM_004697	NP_004688	O43172	PRP4_HUMAN	PRP4 pre-mRNA processing factor 4 homolog	439	WD 5.					Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			ovary(2)|pancreas(1)	3						CTCCGACAGCGGCGTTGCGTC	0.468		NaN											1	0	1.49673e-21	0.00623	1.68139e-21	40	15									
MXRA5	25878	broad.mit.edu	37	X	3229321	3229321	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:3229321G>A	uc004crg.3	-	7	7080	c.6923C>T	c.(6922-6924)ACA>ATA	p.T2308I		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2308	Ig-like C2-type 7.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AAAGTAGAGTGTCCCATTGTT	0.537		NaN											0	0	0	0.01441	0	60	82									
MXRA5	25878	broad.mit.edu	37	X	3239768	3239768	+	Missense_Mutation	SNP	T	T	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:3239768T>A	uc004crg.3	-	5	4115	c.3958A>T	c.(3958-3960)ACA>TCA	p.T1320S		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1320						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCATCTGATGTGGGTTTATAT	0.363		NaN											0	0	0	0.004656	0	26	131									
TLR7	51284	broad.mit.edu	37	X	12904760	12904760	+	Missense_Mutation	SNP	G	G	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:12904760G>C	uc004cvc.2	+	3	1272	c.1133G>C	c.(1132-1134)AGA>ACA	p.R378T		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	378	Extracellular (Potential).|LRR 13.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	CTGCGGATCAGAGGATATGTC	0.338		NaN											0	0	0	0.001855	0	14	83									
TLR7	51284	broad.mit.edu	37	X	12905270	12905270	+	Missense_Mutation	SNP	A	A	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:12905270A>T	uc004cvc.2	+	3	1782	c.1643A>T	c.(1642-1644)GAC>GTC	p.D548V		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	548	Extracellular (Potential).|LRR 18.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	AGATATTTGGACTTCTCCAAC	0.388		NaN											0	0	0	0.01441	0	98	174									
PIR	8544	broad.mit.edu	37	X	15509315	15509315	+	Silent	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:15509315C>T	uc004cwu.2	-	2	304	c.66G>A	c.(64-66)GCG>GCA	p.A22A	PIR_uc004cwv.2_Silent_p.A22A|BMX_uc004cww.2_Intron	NM_003662	NP_003653	O00625	PIR_HUMAN	pirin	22					transcription from RNA polymerase II promoter	cytoplasm|nucleus	metal ion binding|protein binding|quercetin 2,3-dioxygenase activity|transcription cofactor activity			ovary(1)	1	Hepatocellular(33;0.183)					TCCGGACCCTCGCTCCAACCC	0.522		NaN											0	0	0	0.01441	0	93	117									
ZRSR2	8233	broad.mit.edu	37	X	15821884	15821884	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:15821884G>A	uc004cxg.3	+	4	322	c.277G>A	c.(277-279)GAA>AAA	p.E93K		NM_005089	NP_005080	Q15696	U2AFM_HUMAN	U2 small nuclear RNA auxiliary factor 1-like 2	93					spliceosome assembly	U12-type spliceosomal complex	nucleotide binding|pre-mRNA 3'-splice site binding|protein binding|zinc ion binding			breast(3)	3	Hepatocellular(33;0.183)					GAAGGAAAAGGAAGAGGCGGC	0.378		NaN											0	0	0	0.009096	0	4	13									
CDKL5	6792	broad.mit.edu	37	X	18643279	18643279	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:18643279C>A	uc004cym.2	+	17	2661	c.2408C>A	c.(2407-2409)ACG>AAG	p.T803K	CDKL5_uc004cyn.2_Missense_Mutation_p.T803K	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	803					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					GATCTTCTGACGTTGCAGAAA	0.483		NaN											1	0	6.25564e-26	0.01441	7.16706e-26	62	84									
RPS6KA3	6197	broad.mit.edu	37	X	20205975	20205975	+	Missense_Mutation	SNP	C	C	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:20205975C>T	uc004czu.2	-	9	745	c.745G>A	c.(745-747)GCT>ACT	p.A249T	RPS6KA3_uc011mjk.1_Missense_Mutation_p.A220T|RPS6KA3_uc004czv.2_Missense_Mutation_p.A237T|RPS6KA3_uc011mjl.1_Missense_Mutation_p.A221T|RPS6KA3_uc011mjm.1_Missense_Mutation_p.A221T	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	249	Protein kinase 1.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						CACCAGTCAGCACTCTGAGTA	0.393		NaN											0	0	0	0.00874	0	41	71									
KDM6A	7403	broad.mit.edu	37	X	44969392	44969392	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:44969392C>A	uc004dge.3	+	28	4449	c.4074C>A	c.(4072-4074)TGC>TGA	p.C1358*	KDM6A_uc011mkz.1_Nonsense_Mutation_p.C1410*|KDM6A_uc011mla.1_Nonsense_Mutation_p.C1313*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.C1365*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.C1062*|KDM6A_uc011mld.1_Nonsense_Mutation_p.C997*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1358					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAGTACATTGCCAAGATTGTG	0.368		NaN	D|N|F|S		renal|oesophageal SCC|MM								1	0	7.93312e-07	0.00245	8.34304e-07	14	34									
FOXP3	50943	broad.mit.edu	37	X	49107796	49107796	+	Nonstop_Mutation	SNP	C	C	G			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:49107796C>G	uc004dnf.3	-	12	1483	c.1295G>C	c.(1294-1296)TGA>TCA	p.*432S	FOXP3_uc011mnb.1_Nonstop_Mutation_p.*455S|FOXP3_uc011mnc.1_Nonstop_Mutation_p.*405S|FOXP3_uc004dne.3_Nonstop_Mutation_p.*397S|FOXP3_uc010niq.1_3'UTR	NM_014009	NP_054728	Q9BZS1	FOXP3_HUMAN	forkhead box P3 isoform a	432					B cell homeostasis|cerebellum development|chromatin remodeling|embryo development|myeloid cell homeostasis|negative regulation of activated T cell proliferation|negative regulation of chronic inflammatory response|negative regulation of CREB transcription factor activity|negative regulation of cytokine secretion|negative regulation of histone acetylation|negative regulation of histone deacetylation|negative regulation of interferon-gamma biosynthetic process|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|negative regulation of interleukin-2 biosynthetic process|negative regulation of interleukin-2 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of interleukin-6 production|negative regulation of isotype switching to IgE isotypes|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell cytokine production|negative regulation of tumor necrosis factor production|pattern specification process|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|positive regulation of histone acetylation|positive regulation of immature T cell proliferation in thymus|positive regulation of peripheral T cell tolerance induction|positive regulation of T cell anergy|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor-beta1 production|post-embryonic development|regulation of isotype switching to IgG isotypes|response to virus|T cell homeostasis|T cell receptor signaling pathway|tolerance induction to self antigen	cytoplasm|cytoplasm|nucleus|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|histone acetyltransferase binding|histone deacetylase binding|NF-kappaB binding|NFAT protein binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription corepressor activity|zinc ion binding				0	Ovarian(276;0.236)					ATCTTGAGGTCAGGGGCCAGG	0.617		NaN											0	0	0	0.008291	0	9	23									
ZXDB	158586	broad.mit.edu	37	X	57619922	57619922	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:57619922G>A	uc004dvd.2	+	1	1654	c.1441G>A	c.(1441-1443)GAC>AAC	p.D481N		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	481	Required for interaction with ZXDC (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						GCACGACGATGACCGGAGGTT	0.517		NaN											0	0	0	0.01441	0	53	76									
LAS1L	81887	broad.mit.edu	37	X	64734785	64734785	+	Missense_Mutation	SNP	T	T	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:64734785T>A	uc004dwa.1	-	13	2068	c.1996A>T	c.(1996-1998)ATG>TTG	p.M666L	LAS1L_uc004dwc.1_Missense_Mutation_p.M649L|LAS1L_uc004dwd.1_Missense_Mutation_p.M607L|LAS1L_uc004dvy.1_Missense_Mutation_p.M179L|LAS1L_uc004dvz.1_Missense_Mutation_p.M179L	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	666						MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4						TTCTCCAGCATGAGCTCTGCT	0.557		NaN											0	0	0	0.013537	0	13	22									
OGT	8473	broad.mit.edu	37	X	70784453	70784453	+	Silent	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:70784453C>A	uc004eaa.1	+	19	2656	c.2439C>A	c.(2437-2439)ATC>ATA	p.I813I	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Silent_p.I803I|OGT_uc004eac.2_Silent_p.I674I|OGT_uc004ead.2_Silent_p.I432I	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	813					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					TGTTCTAGATCAACAATAAGG	0.383		NaN											1	0	3.32936e-07	0.006122	3.53361e-07	17	22									
STAG2	10735	broad.mit.edu	37	X	123182853	123182853	+	Splice_Site	SNP	A	A	C			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			A	C	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:123182853A>C	uc004etz.3	+	9	1159	c.820_splice	c.e9-2	p.L274_splice	STAG2_uc004eua.2_Splice_Site_p.L274_splice|STAG2_uc004eub.2_Splice_Site_p.L274_splice|STAG2_uc004euc.2_Splice_Site_p.L274_splice|STAG2_uc004eud.2_Splice_Site_p.L274_splice|STAG2_uc004eue.2_Splice_Site_p.L274_splice	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b						cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GTTTTTTTACAGCTTCAGGAA	0.308		NaN											0	0	0	0.00278	0	24	26									
MAGEC2	51438	broad.mit.edu	37	X	141291023	141291024	+	Nonsense_Mutation	DNP	CC	CC	TT			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:141291023_141291024CC>TT	uc004fbu.1	-	3	1098_1099	c.750_751GG>AA	c.(748-753)TGGGAA>TGAAAA	p.250_251WE>*K		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	250_251	MAGE.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTCAGCACTTCCCAGATGACCT	0.515		NaN								HNSCC(46;0.14)			0	0	0	0.004672	0	59	129									
SPANXN2	494119	broad.mit.edu	37	X	142803727	142803727	+	Missense_Mutation	SNP	C	C	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:142803727C>A	uc004fbz.2	-	1	790	c.36G>T	c.(34-36)AAG>AAT	p.K12N		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	12										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GGCTCTTCCTCTTCTCCCCAT	0.318		NaN											1	0	2.165e-29	0.01441	2.50532e-29	58	205									
MTM1	4534	broad.mit.edu	37	X	149809841	149809841	+	Missense_Mutation	SNP	G	G	T			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:149809841G>T	uc004fef.3	+	8	704	c.628G>T	c.(628-630)GAT>TAT	p.D210Y	MTM1_uc011mxx.1_RNA|MTM1_uc011mxy.1_Missense_Mutation_p.D173Y|MTM1_uc011mxz.1_Missense_Mutation_p.D95Y|MTM1_uc010nte.2_Missense_Mutation_p.D78Y	NM_000252	NP_000243	Q13496	MTM1_HUMAN	myotubularin	210	Myotubularin phosphatase.				endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCGTGCCTCAGATGATGACCT	0.438		NaN											1	0	3.86212e-05	0.008291	4.01289e-05	10	54									
PNCK	139728	broad.mit.edu	37	X	152937346	152937346	+	Missense_Mutation	SNP	G	G	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:152937346G>A	uc011myu.1	-	5	838	c.652C>T	c.(652-654)CGG>TGG	p.R218W	PNCK_uc011myt.1_Missense_Mutation_p.R152W|PNCK_uc004fia.2_Missense_Mutation_p.R147W|PNCK_uc004fhz.3_Missense_Mutation_p.R33W|PNCK_uc010nuh.2_3'UTR|PNCK_uc011myv.1_Missense_Mutation_p.R162W|PNCK_uc011myw.1_Missense_Mutation_p.R162W	NM_001039582	NP_001034671	Q6P2M8	KCC1B_HUMAN	pregnancy upregulated non-ubiquitously expressed	135	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTGAGGTCCCGGTGCACGATC	0.662		NaN											0	0	0	0.001168	0	6	18									
KLHDC7A	127707	broad.mit.edu	37	1	18807481	18807497	+	Frame_Shift_Del	DEL	CCCCAGAGGAGCAGAGG	CCCCAGAGGAGCAGAGG	-			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:18807481_18807497delCCCCAGAGGAGCAGAGG	uc001bax.2	+	1	58_74	c.6_22delCCCCAGAGGAGCAGAGG	c.(4-24)TTCCCCAGAGGAGCAGAGGCCfs	p.F2fs	KLHDC7A_uc009vpg.2_5'Flank	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	2_8						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGCATGTTCCCCAGAGGAGCAGAGGCCCAGGACTG	0.581		NaN											NaN	NaN	NaN	NaN	NaN	15	31	---	---							
SLAMF1	6504	broad.mit.edu	37	1	160589601	160589601	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:160589601delT	uc001fwl.3	-	5	1175	c.829delA	c.(829-831)AGCfs	p.S277fs	SLAMF1_uc010pjk.1_Intron|SLAMF1_uc010pjl.1_Intron|SLAMF1_uc010pjm.1_Intron	NM_003037	NP_003028	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family	277	Cytoplasmic (Potential).|Ig-like V-type.				interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			ovary(1)|breast(1)	2	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ATCGTAAGGCTTTTTTTTTCC	0.433		NaN											NaN	NaN	NaN	NaN	NaN	8	131	---	---							
ELF3	1999	broad.mit.edu	37	1	201983137	201983153	+	Splice_Site	DEL	TGAGCCGGGCCATGAGG	TGAGCCGGGCCATGAGG	-			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			TGAGCCGGGCCATGAGG	-	TGAGCCGGGCCATGAGG	TGAGCCGGGCCATGAGG		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:201983137_201983153delTGAGCCGGGCCATGAGG	uc001gxg.3	+	7	4193	c.1001_splice	c.e7+1	p.R334_splice	ELF3_uc001gxi.3_Splice_Site_p.R334_splice|ELF3_uc001gxh.3_Splice_Site_p.R334_splice	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription						epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						TACGAGAAGCTGAGCCGGGCCATGAGGTGAGCTGGCG	0.59		NaN											NaN	NaN	NaN	NaN	NaN	14	3	---	---							
ABCC8	6833	broad.mit.edu	37	11	17428979	17428979	+	Frame_Shift_Del	DEL	C	C	-			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:17428979delC	uc001mnc.2	-	24	2968	c.2842delG	c.(2842-2844)GCCfs	p.A948fs		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	948	Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GGCTCTGTGGCTTTTCTCTCT	0.542		NaN											NaN	NaN	NaN	NaN	NaN	20	78	---	---							
LCAT	3931	broad.mit.edu	37	16	67974100	67974109	+	Frame_Shift_Del	DEL	GCAGGCCCAC	GCAGGCCCAC	-			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:67974100_67974109delGCAGGCCCAC	uc002euy.1	-	6	1032_1041	c.1021_1030delGTGGGCCTGC	c.(1021-1032)GTGGGCCTGCCCfs	p.V341fs		NM_000229	NP_000220	P04180	LCAT_HUMAN	lecithin-cholesterol acyltransferase precursor	341_344					cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|reverse cholesterol transport|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein A-I binding|phosphatidylcholine-sterol O-acyltransferase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00418)|Epithelial(162;0.0183)|all cancers(182;0.12)		CGGGGCGTGGGCAGGCCCACGCCGTAAAGA	0.61		NaN											NaN	NaN	NaN	NaN	NaN	30	121	---	---							
HERC6	55008	broad.mit.edu	37	4	89300153	89300161	+	In_Frame_Del	DEL	AGGCGGCCA	AGGCGGCCA	-			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:89300153_89300161delAGGCGGCCA	uc011cdi.1	+	1	263_271	c.80_88delAGGCGGCCA	c.(79-90)CAGGCGGCCAGC>CGC	p.27_30QAAS>R	HERC6_uc003hrp.1_RNA|HERC6_uc011cdj.1_In_Frame_Del_p.27_30QAAS>R|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_RNA	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	27_30					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		GAGCTACTGCAGGCGGCCAGCGGGGAGCG	0.722		NaN											NaN	NaN	NaN	NaN	NaN	7	10	---	---							
TMED9	54732	broad.mit.edu	37	5	177019252	177019268	+	Frame_Shift_Del	DEL	CGGCCCGGAACCGGGCT	CGGCCCGGAACCGGGCT	-	rs57960711	byFrequency	TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:177019252_177019268delCGGCCCGGAACCGGGCT	uc003mhx.2	+	1	40_56	c.37_53delCGGCCCGGAACCGGGCT	c.(37-54)CGGCCCGGAACCGGGCTGfs	p.R13fs	TMED9_uc010jko.2_RNA	NM_017510	NP_059980	Q9BVK6	TMED9_HUMAN	transmembrane emp24 protein transport domain	13_18					transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane					0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGTCCGGCCCCGGCCCGGAACCGGGCTGGGTAGAGTG	0.696		NaN											NaN	NaN	NaN	NaN	NaN	10	10	---	---							
ICK	22858	broad.mit.edu	37	6	52883129	52883129	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:52883129delT	uc003pbh.2	-	8	1152	c.662delA	c.(661-663)AAGfs	p.K221fs	ICK_uc003pbi.2_Frame_Shift_Del_p.K221fs|ICK_uc003pbj.2_Frame_Shift_Del_p.K221fs	NM_016513	NP_057597	Q9UPZ9	ICK_HUMAN	intestinal cell kinase	221	Protein kinase.				intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			ovary(1)|large_intestine(1)|lung(1)|kidney(1)|central_nervous_system(1)	5	Lung NSC(77;0.103)					TATCATTACCTTTTTTGGTGT	0.502		NaN											NaN	NaN	NaN	NaN	NaN	7	175	---	---							
FER1L6	654463	broad.mit.edu	37	8	125015471	125015472	+	Frame_Shift_Ins	INS	-	-	A			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:125015471_125015472insA	uc003yqw.2	+	13	1790_1791	c.1584_1585insA	c.(1582-1587)GCTGAAfs	p.A528fs	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	528_529	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CTGAATCAGCTGAAGAAGACCT	0.535		NaN											NaN	NaN	NaN	NaN	NaN	20	46	---	---							
