Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
MIB2	142678	broad.mit.edu	37	1	1564037	1564037	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:1564037C>G	uc001agg.2	+	16	2438	c.2311C>G	c.(2311-2313)CAG>GAG	p.Q771E	MIB2_uc001agh.2_Missense_Mutation_p.Q757E|MIB2_uc001agi.2_Missense_Mutation_p.Q767E|MIB2_uc001agj.2_Missense_Mutation_p.Q612E|MIB2_uc001agk.2_Missense_Mutation_p.Q706E|MIB2_uc001agl.1_Missense_Mutation_p.Q727E|MIB2_uc001agm.2_Missense_Mutation_p.Q648E|MIB2_uc010nyq.1_Missense_Mutation_p.Q727E|MIB2_uc009vkh.2_Missense_Mutation_p.Q577E|MIB2_uc001agn.2_Missense_Mutation_p.Q403E|MIB2_uc001ago.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	771	ANK 8.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GCAGCGTCATCAGCTGCTGCC	0.701		NaN											0	0	0	0.000248	0	4	5									
MEGF6	1953	broad.mit.edu	37	1	3421837	3421837	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:3421837T>C	uc001akl.2	-	17	2350	c.2123A>G	c.(2122-2124)GAC>GGC	p.D708G	MEGF6_uc001akk.2_Missense_Mutation_p.D603G	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	708						extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCTCACGGAGTCACAGGCCAC	0.692		NaN											0	0	0	0.001168	0	6	35									
NOL9	79707	broad.mit.edu	37	1	6589194	6589194	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:6589194G>C	uc001ans.2	-	10	1704	c.1685C>G	c.(1684-1686)TCT>TGT	p.S562C	NOL9_uc010nzs.1_RNA	NM_024654	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	562					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			skin(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		GGCGACATCAGAGTGGGTAAT	0.468		NaN											0	0	0	0.001984	0	6	46									
RERE	473	broad.mit.edu	37	1	8424172	8424172	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:8424172C>G	uc001ape.2	-	16	2494	c.1684G>C	c.(1684-1686)GAG>CAG	p.E562Q	RERE_uc001apf.2_Missense_Mutation_p.E562Q|RERE_uc010nzx.1_Missense_Mutation_p.E294Q|RERE_uc001apd.2_Missense_Mutation_p.E8Q	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	562					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CCATCATCCTCTTCCTTGACG	0.587		NaN											0	0	0	0.001855	0	13	77									
SLC25A33	84275	broad.mit.edu	37	1	9633411	9633411	+	Silent	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:9633411C>A	uc001apw.2	+	5	646	c.423C>A	c.(421-423)ATC>ATA	p.I141I	SLC25A33_uc001apx.2_Silent_p.I74I	NM_032315	NP_115691	Q9BSK2	S2533_HUMAN	mitochondrial carrier protein MGC4399	141	Solcar 2.|Helical; Name=3; (Potential).				transport	integral to membrane|mitochondrial inner membrane					0	all_lung(157;0.246)	all_epithelial(116;1.16e-18)|all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Breast(348;0.00191)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.44e-05)|Kidney(185;0.000262)|KIRC - Kidney renal clear cell carcinoma(229;0.000957)|BRCA - Breast invasive adenocarcinoma(304;0.0019)|STAD - Stomach adenocarcinoma(132;0.00355)|READ - Rectum adenocarcinoma(331;0.0419)		CAGCTTTTATCACAAATTCCT	0.294		NaN											1	0	0.00116845	0.001168	0.0013894	6	20									
SRM	6723	broad.mit.edu	37	1	11116794	11116794	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:11116794C>A	uc001arz.1	-	4	493	c.402G>T	c.(400-402)AAG>AAT	p.K134N	SRM_uc001ary.1_5'UTR	NM_003132	NP_003123	P19623	SPEE_HUMAN	spermidine synthase	134					spermidine biosynthetic process	cytosol	protein homodimerization activity|spermidine synthase activity				0	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.228)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)	S-Adenosylmethionine(DB00118)|Spermine(DB00127)	GCAGGAACTTCTTGGAGACTT	0.577		NaN											1	0	6.40141e-05	0.000978	7.64982e-05	11	48									
VPS13D	55187	broad.mit.edu	37	1	12326961	12326961	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:12326961C>G	uc001atv.2	+	14	1759	c.1618C>G	c.(1618-1620)CTT>GTT	p.L540V	VPS13D_uc001atw.2_Missense_Mutation_p.L540V	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	540					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGCAGAGTCTCTTCCTCGAAG	0.368		NaN											0	0	0	0.001882	0	22	42									
VPS13D	55187	broad.mit.edu	37	1	12336868	12336868	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:12336868G>C	uc001atv.2	+	19	3364	c.3223G>C	c.(3223-3225)GAG>CAG	p.E1075Q	VPS13D_uc001atw.2_Missense_Mutation_p.E1075Q|VPS13D_uc001atx.2_Missense_Mutation_p.E263Q	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1075					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TCTTACCAAAGAGCAAGAGTC	0.438		NaN									OREG0013110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.002836	0	32	80									
ARHGEF19	128272	broad.mit.edu	37	1	16532692	16532692	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:16532692G>C	uc001ayc.1	-	7	1418	c.1281C>G	c.(1279-1281)GTC>GTG	p.V427V	ARHGEF19_uc009voo.1_5'UTR|ARHGEF19_uc001ayb.1_5'UTR	NM_153213	NP_694945	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	427	DH.				regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTGCTCTTGACCTCGGGCA	0.647		NaN											0	0	0	0.001984	0	5	14									
KLHDC7A	127707	broad.mit.edu	37	1	18808555	18808555	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:18808555C>T	uc001bax.2	+	1	1132	c.1080C>T	c.(1078-1080)TTC>TTT	p.F360F	KLHDC7A_uc009vpg.2_Silent_p.F142F	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	360	Kelch 1.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCCGAGGCTTCAGCCGGAAGG	0.692		NaN											0	0	0	0.00308	0	5	23									
UBR4	23352	broad.mit.edu	37	1	19494588	19494588	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:19494588G>T	uc001bbi.2	-	28	3836	c.3832C>A	c.(3832-3834)CTG>ATG	p.L1278M	UBR4_uc001bbm.1_Missense_Mutation_p.L489M	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1278					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GCCAGGGGCAGACTTTGGCTA	0.512		NaN											1	0	6.05902e-23	0.003755	7.72123e-23	36	78									
CLIC4	25932	broad.mit.edu	37	1	25167380	25167380	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:25167380G>A	uc001bjo.2	+	6	999	c.714G>A	c.(712-714)AAG>AAA	p.K238K	CLIC4_uc001bjn.2_RNA|CLIC4_uc001bjp.1_Silent_p.K218K	NM_013943	NP_039234	Q9Y696	CLIC4_HUMAN	chloride intracellular channel 4	238	GST C-terminal.				cellular response to calcium ion|establishment or maintenance of apical/basal cell polarity|keratinocyte differentiation|negative regulation of cell migration|regulation of cytoskeleton organization	actin cytoskeleton|apical part of cell|cell surface|cell-cell junction|centrosome|chloride channel complex|cytoplasmic vesicle membrane|cytosol|microvillus|midbody|mitochondrion|nuclear matrix|perinuclear region of cytoplasm|soluble fraction	voltage-gated chloride channel activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000778)|all_lung(284;0.00106)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0479)|OV - Ovarian serous cystadenocarcinoma(117;1.06e-24)|Colorectal(126;1.03e-07)|COAD - Colon adenocarcinoma(152;4.93e-06)|STAD - Stomach adenocarcinoma(196;0.000418)|GBM - Glioblastoma multiforme(114;0.000451)|BRCA - Breast invasive adenocarcinoma(304;0.00215)|KIRC - Kidney renal clear cell carcinoma(1967;0.00216)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.18)		CCAGTGATAAGGAGGTTGAAA	0.398		NaN											0	0	0	0.004878	0	34	78									
FAM46B	115572	broad.mit.edu	37	1	27332842	27332842	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:27332842G>A	uc010ofj.1	-	2	1043	c.871C>T	c.(871-873)CGG>TGG	p.R291W		NM_052943	NP_443175	Q96A09	FA46B_HUMAN	hypothetical protein LOC115572	291										central_nervous_system(1)	1		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)		GGCCGGGGCCGGAAGCCCCGC	0.677		NaN											0	0	0	0.00308	0	7	33									
TAF12	6883	broad.mit.edu	37	1	28931934	28931934	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:28931934C>T	uc001bqw.2	-	4	493	c.400G>A	c.(400-402)GAA>AAA	p.E134K	TAF12_uc001bqx.2_Missense_Mutation_p.E134K|TAF12_uc001bqy.2_Missense_Mutation_p.E134K|TAF12_uc009vti.2_Missense_Mutation_p.E134K	NM_005644	NP_005635	Q16514	TAF12_HUMAN	TAF12 RNA polymerase II, TATA box binding	134					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Renal(390;0.00121)|Breast(348;0.00502)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)		Colorectal(126;3.21e-08)|COAD - Colon adenocarcinoma(152;1.74e-06)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(1967;0.0109)|BRCA - Breast invasive adenocarcinoma(304;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		CGGATTTCTTCAGAGCCAAAT	0.517		NaN											0	0	0	0.003271	0	35	88									
CCDC28B	79140	broad.mit.edu	37	1	32669900	32669900	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:32669900G>C	uc001bul.1	+	4	577	c.445G>C	c.(445-447)GAG>CAG	p.E149Q	CCDC28B_uc001buk.2_Missense_Mutation_p.E149Q|IQCC_uc001bum.2_5'Flank|IQCC_uc009vua.2_5'Flank|IQCC_uc010ogz.1_5'Flank	NM_024296	NP_077272	Q9BUN5	CC28B_HUMAN	coiled-coil domain containing 28B	149											0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TGAAGAGGAAGAGGATGGGGT	0.582		NaN											0	0	0	0.006214	0	9	55									
CSMD2	114784	broad.mit.edu	37	1	33985159	33985159	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:33985159C>T	uc001bxn.1	-	69	10452	c.10423G>A	c.(10423-10425)GAG>AAG	p.E3475K	CSMD2_uc001bxm.1_Missense_Mutation_p.E3619K	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3475	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AACTCCGCCTCGCTGGCCATG	0.612		NaN											0	0	0	0.002222	0	44	178									
CLSPN	63967	broad.mit.edu	37	1	36202663	36202663	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:36202663G>C	uc001bzi.2	-	24	3841	c.3761C>G	c.(3760-3762)TCA>TGA	p.S1254*	CLSPN_uc009vux.2_Nonsense_Mutation_p.S1190*	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	1254					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTTTAGCAGTGAGCCTGTCTT	0.463		NaN											0	0	0	0.001523	0	21	107									
MRPS15	64960	broad.mit.edu	37	1	36927747	36927747	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:36927747C>T	uc001cas.2	-	3	357	c.193G>A	c.(193-195)GAT>AAT	p.D65N		NM_031280	NP_112570	P82914	RT15_HUMAN	mitochondrial ribosomal protein S15 precursor	65				GGGSAKFPFNQWGLQPRSLLLQAARGYVVRKPAQSRLDDDP PPSTLLKDYQNV -> AVGAPSFLSTSGACSLEVSSSRPRA DMSSGNQPSLGWMMTHLLLRCSKTTRMS (in Ref. 2; AAG44697).	translation	mitochondrial small ribosomal subunit|nuclear membrane	structural constituent of ribosome			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGTGGGTCATCATCCAGCCTA	0.537		NaN											0	0	0	0.002096	0	31	39									
EPHA10	284656	broad.mit.edu	37	1	38192827	38192827	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:38192827G>A	uc009vvi.2	-	8	1805	c.1719C>T	c.(1717-1719)ATC>ATT	p.I573I	EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	573	Helical; (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGAGGGCCGAGATGGTCACTA	0.637		NaN											0	0	0	0.001168	0	6	26									
KIAA0754	643314	broad.mit.edu	37	1	39879406	39879406	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:39879406G>A	uc009vvt.1	+	1	4231	c.3469G>A	c.(3469-3471)GCC>ACC	p.A1157T	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	1021	Ala-rich.|12.										0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGAGGAATCCGCCTCCGCAGC	0.682		NaN											0	0	0	0.001168	0	6	33									
NT5C1A	84618	broad.mit.edu	37	1	40131848	40131848	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:40131848C>G	uc001cdq.1	-	2	196	c.196G>C	c.(196-198)GAG>CAG	p.E66Q		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	66					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TGCTGCTCCTCGTCCATGCGA	0.582		NaN											0	0	0	0.001855	0	13	60									
KIAA0467	23334	broad.mit.edu	37	1	43896036	43896036	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:43896036G>C	uc001cjk.1	+	16	2221	c.1759G>C	c.(1759-1761)GAG>CAG	p.E587Q		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1486						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGAGTTTTCAGAGGCTGAGCT	0.522		NaN											0	0	0	0.008361	0	27	59									
KIAA0467	23334	broad.mit.edu	37	1	43896196	43896196	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:43896196G>T	uc001cjk.1	+	17	2275	c.1813G>T	c.(1813-1815)GAG>TAG	p.E605*		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1504						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGTGGTCACTGAGAGTGACCC	0.562		NaN											1	0	4.22769e-11	0.00632	5.26178e-11	26	53									
KIAA0467	23334	broad.mit.edu	37	1	43905590	43905590	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:43905590G>C	uc001cjk.1	+	36	4846	c.4384G>C	c.(4384-4386)GAA>CAA	p.E1462Q		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2361						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGATGTGTGGGAAAAGGGGAA	0.577		NaN											0	0	0	0.007291	0	27	45									
KIAA0467	23334	broad.mit.edu	37	1	43908143	43908143	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:43908143G>C	uc001cjk.1	+	43	5770	c.5308G>C	c.(5308-5310)GAC>CAC	p.D1770H		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2669						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGGGCTCCAGACCTGGGGGC	0.617		NaN											0	0	0	0.00333	0	24	55									
HECTD3	79654	broad.mit.edu	37	1	45472910	45472910	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:45472910C>T	uc009vxk.2	-	11	1635	c.1537G>A	c.(1537-1539)GAA>AAA	p.E513K	HECTD3_uc001cmx.3_5'Flank|HECTD3_uc001cmy.3_Missense_Mutation_p.E123K|HECTD3_uc010olh.1_Missense_Mutation_p.E229K	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	513	HECT.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)					AGGGGCTTTTCATATTTGTCA	0.413		NaN											0	0	0	0.00278	0	20	101									
ZSWIM5	57643	broad.mit.edu	37	1	45671765	45671765	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:45671765G>T	uc001cnd.2	-	1	486	c.258C>A	c.(256-258)TTC>TTA	p.F86L		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	86							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					GGATCCGCTCGAAGCGCTCCT	0.627		NaN											1	0	5.16669e-11	0.000978	6.42489e-11	10	24									
CYP4A11	1579	broad.mit.edu	37	1	47399996	47399996	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:47399996C>T	uc001cqp.3	-	8	991	c.940G>A	c.(940-942)GAG>AAG	p.E314K	CYP4A11_uc001cqq.2_Missense_Mutation_p.E314K|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	314					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GTGTCCACCTCAGCACGGAGG	0.547		NaN											0	0	0	0.004656	0	16	24									
CYP4A22	284541	broad.mit.edu	37	1	47610264	47610264	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:47610264G>A	uc001cqv.1	+	8	991	c.940G>A	c.(940-942)GAG>AAG	p.E314K	CYP4A22_uc009vyo.2_Missense_Mutation_p.E314K|CYP4A22_uc009vyp.2_Intron	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	314						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						CCTCCGTGCTGAGGTGGACAC	0.552		NaN											0	0	0	0.003954	0	14	129									
NRD1	4898	broad.mit.edu	37	1	52283797	52283797	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:52283797G>C	uc001ctc.3	-	12	1828	c.1506C>G	c.(1504-1506)ATC>ATG	p.I502M	NRD1_uc009vzb.2_Missense_Mutation_p.I197M|NRD1_uc001ctd.3_Missense_Mutation_p.I434M|NRD1_uc001cte.2_Missense_Mutation_p.I370M|NRD1_uc001ctf.2_Missense_Mutation_p.I434M|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Missense_Mutation_p.I302M	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	433					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						GAATTTTTCTGATTGGAACAA	0.323		NaN											0	0	0	0.00308	0	6	31									
USP24	23358	broad.mit.edu	37	1	55595217	55595217	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:55595217C>T	uc001cyg.3	-	29	3088	c.3088G>A	c.(3088-3090)GAT>AAT	p.D1030N		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	1190					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						ATGTCATCATCAGCTGTTGGC	0.398		NaN											0	0	0	0.004482	0	9	60									
RAVER2	55225	broad.mit.edu	37	1	65243754	65243754	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:65243754C>T	uc001dbs.1	+	3	843	c.765C>T	c.(763-765)GTC>GTT	p.V255V	RAVER2_uc001dbt.1_Silent_p.V134V|RAVER2_uc010opb.1_Silent_p.V134V	NM_018211	NP_060681	Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	255	RRM 3.					cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)	1						TTTCCAGTGTCCATAAACCTG	0.318		NaN											0	0	0	0.00333	0	22	49									
MIER1	57708	broad.mit.edu	37	1	67436578	67436578	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:67436578G>A	uc001dde.2	+	9	994	c.860G>A	c.(859-861)AGA>AAA	p.R287K	MIER1_uc010opf.1_Missense_Mutation_p.R251K|MIER1_uc009way.2_Missense_Mutation_p.R251K|MIER1_uc001ddc.2_Missense_Mutation_p.R287K|MIER1_uc001ddh.2_Missense_Mutation_p.R171K|MIER1_uc001ddf.2_Missense_Mutation_p.R251K|MIER1_uc001ddg.2_Missense_Mutation_p.R207K|MIER1_uc010opg.1_Missense_Mutation_p.R251K|MIER1_uc001ddj.1_Missense_Mutation_p.R234K|MIER1_uc001ddi.2_Missense_Mutation_p.R234K	NM_001077700	NP_001071168	Q8N108	MIER1_HUMAN	mesoderm induction early response 1 isoform b	258	ELM2.|Interaction with HDAC1.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)	1						GCATCTAGAAGAACAGGTGAT	0.358		NaN											0	0	0	0.003163	0	16	61									
PIGK	10026	broad.mit.edu	37	1	77627290	77627290	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:77627290C>G	uc001dhk.2	-	7	736	c.691G>C	c.(691-693)GAT>CAT	p.D231H	PIGK_uc010orj.1_Missense_Mutation_p.D155H|PIGK_uc009wbx.2_Missense_Mutation_p.D137H|PIGK_uc001dhl.1_Missense_Mutation_p.D231H	NM_005482	NP_005473	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	231	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3						GAGAGTGAATCTTCTCCCACT	0.368		NaN											0	0	0	0.00245	0	14	65									
LPHN2	23266	broad.mit.edu	37	1	82409390	82409390	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:82409390G>A	uc001dit.3	+	6	1316	c.1135G>A	c.(1135-1137)GTG>ATG	p.V379M	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.V379M|LPHN2_uc001div.2_Missense_Mutation_p.V379M|LPHN2_uc009wcd.2_Missense_Mutation_p.V379M	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	379	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CCAACTTTACGTGTGGAACAA	0.408		NaN											0	0	0	0.00278	0	24	91									
RBMXL1	494115	broad.mit.edu	37	1	89449287	89449287	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:89449287C>A	uc009wcx.2	-	3	939	c.223G>T	c.(223-225)GAT>TAT	p.D75Y	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_Missense_Mutation_p.D75Y	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	75	RRM.						nucleotide binding|RNA binding				0						GCTTTTCCATCTAATGACTTT	0.478		NaN									OREG0013593	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.48254e-18	0.00361	3.14135e-18	53	169									
GBP3	2635	broad.mit.edu	37	1	89486323	89486323	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:89486323G>T	uc001dmt.2	-	2	287	c.82C>A	c.(82-84)CTG>ATG	p.L28M	GBP3_uc010oss.1_Translation_Start_Site|GBP3_uc001dmu.2_Translation_Start_Site|GBP3_uc001dmv.2_RNA	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	28	Helical; (Potential).					integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		AGGATTTTCAGAGCTTCTGGA	0.517		NaN											1	0	6.05902e-23	0.003755	7.72123e-23	37	106									
TGFBR3	7049	broad.mit.edu	37	1	92184913	92184913	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:92184913G>A	uc001doh.2	-	10	1988	c.1522C>T	c.(1522-1524)CGG>TGG	p.R508W	TGFBR3_uc009wde.2_Missense_Mutation_p.R285W|TGFBR3_uc010osy.1_Missense_Mutation_p.R466W|TGFBR3_uc001doi.2_Missense_Mutation_p.R507W|TGFBR3_uc001doj.2_Missense_Mutation_p.R507W	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	508	ZP.|Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		CACCGGGGCCGAGTACCGCAG	0.547		NaN											0	0	0	0.002836	0	35	62									
EVI5	7813	broad.mit.edu	37	1	93091443	93091443	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:93091443C>T	uc001dox.2	-	13	1538	c.1528G>A	c.(1528-1530)GAA>AAA	p.E510K	EVI5_uc010otf.1_Missense_Mutation_p.E521K|EVI5_uc001doy.1_RNA	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	510	Targeting to the centrosomes.|Potential.|Dimerization.|Interaction with AURKB and INCENP.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		GCAATGAGTTCTTCCTGAAGC	0.338		NaN											0	0	0	0.001786	0	31	46									
ARHGAP29	9411	broad.mit.edu	37	1	94655506	94655506	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:94655506G>A	uc001dqj.3	-	13	1784	c.1415C>T	c.(1414-1416)TCA>TTA	p.S472L	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dqk.2_Missense_Mutation_p.S38L	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	472					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTCTTCAGTTGAATTTGTGGC	0.368		NaN											0	0	0	0.000978	0	12	60									
SLC30A7	148867	broad.mit.edu	37	1	101387384	101387384	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:101387384C>G	uc001dtn.2	+	8	1016	c.829C>G	c.(829-831)CTT>GTT	p.L277V	SLC30A7_uc001dto.2_Missense_Mutation_p.L277V	NM_001144884	NP_001138356	Q8NEW0	ZNT7_HUMAN	zinc transporter like 2	277	Helical; (Potential).				zinc ion transport	Golgi apparatus|integral to membrane	cation transmembrane transporter activity|protein binding				0		all_epithelial(167;0.000445)|all_lung(203;0.00645)|Lung NSC(277;0.0119)		Epithelial(280;0.0437)|all cancers(265;0.0498)|COAD - Colon adenocarcinoma(174;0.162)|Colorectal(144;0.19)|Lung(183;0.201)		TATAGCCATTCTTATAGTTGT	0.303		NaN											0	0	0	0.001855	0	13	80									
COL11A1	1301	broad.mit.edu	37	1	103478004	103478004	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:103478004C>T	uc001dul.2	-	14	1912	c.1594G>A	c.(1594-1596)GGC>AGC	p.G532S	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.G544S|COL11A1_uc001dun.2_Missense_Mutation_p.G493S|COL11A1_uc009weh.2_Missense_Mutation_p.G416S	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	532	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCCATTGGGCCAGGTGGGCCT	0.388		NaN											0	0	0	0.008291	0	9	24									
EPS8L3	79574	broad.mit.edu	37	1	110301959	110301959	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:110301959C>T	uc001dyr.1	-	5	451	c.306G>A	c.(304-306)GCG>GCA	p.A102A	EPS8L3_uc001dys.1_Silent_p.A102A|EPS8L3_uc001dyq.1_Silent_p.A102A|EPS8L3_uc009wfm.1_Silent_p.A68A|EPS8L3_uc009wfn.1_Silent_p.A68A|EPS8L3_uc009wfo.1_Silent_p.A49A	NM_133181	NP_573444	Q8TE67	ES8L3_HUMAN	epidermal growth factor receptor pathway	102						cytoplasm	protein binding			ovary(2)|skin(1)	3		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		ATGTGTTGAGCGCCACATTCA	0.607		NaN											0	0	0	0.00361	0	68	144									
CHIA	27159	broad.mit.edu	37	1	111854934	111854934	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:111854934G>A	uc001eas.2	+	4	281	c.178G>A	c.(178-180)GGG>AGG	p.G60R	CHIA_uc001ear.2_Intron|CHIA_uc001eaq.2_Intron|CHIA_uc009wgc.2_Intron|CHIA_uc001eat.2_Intron|CHIA_uc001eav.2_Intron|CHIA_uc001eau.2_Intron|CHIA_uc009wgd.2_Intron	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c	60					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		CGCCTTTGCTGGGAGGCAGAA	0.522		NaN											0	0	0	0.00245	0	14	119									
DDX20	11218	broad.mit.edu	37	1	112309338	112309338	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:112309338G>C	uc001ebs.2	+	11	2649	c.2292G>C	c.(2290-2292)CTG>CTC	p.L764L	DDX20_uc010owf.1_Silent_p.L526L|DDX20_uc001ebt.2_Silent_p.L372L	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	764					assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAATACGTCTGAGTTTTTCTG	0.453		NaN											0	0	0	0.001984	0	5	55									
ST7L	54879	broad.mit.edu	37	1	113159453	113159453	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:113159453C>T	uc001ecd.2	-	2	575	c.270G>A	c.(268-270)TTG>TTA	p.L90L	ST7L_uc001ecc.2_5'UTR|ST7L_uc010owg.1_Silent_p.L90L|ST7L_uc010owh.1_Silent_p.L90L|ST7L_uc001ece.2_Silent_p.L90L|ST7L_uc001ecf.2_Silent_p.L73L|ST7L_uc001ecg.2_RNA|ST7L_uc010owi.1_Silent_p.L25L|ST7L_uc001ech.2_Silent_p.L73L|ST7L_uc001eci.2_Silent_p.L90L|ST7L_uc009wgi.1_Intron|ST7L_uc010owj.1_Silent_p.L73L|CAPZA1_uc001ecj.1_5'Flank	NM_017744	NP_060214	Q8TDW4	ST7L_HUMAN	suppression of tumorigenicity 7-like isoform 1	90	Helical; (Potential).				negative regulation of cell growth	integral to membrane	binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTCCTGATATCAATGAAGAGG	0.264		NaN											0	0	0	0.000978	0	10	105									
AMPD1	270	broad.mit.edu	37	1	115236063	115236063	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:115236063C>A	uc001efe.1	-	2	112	c.28G>T	c.(28-30)GAG>TAG	p.E10*	AMPD1_uc001eff.1_Intron	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	10					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|large_intestine(1)|skin(1)	4	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TCACGTTTCTCTTCAGCTGTA	0.323		NaN											1	0	1.64293e-13	0.00333	2.05545e-13	22	75									
ATP1A1	476	broad.mit.edu	37	1	116935566	116935566	+	Missense_Mutation	SNP	G	G	A	rs148719009		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:116935566G>A	uc001ege.2	+	11	1762	c.1423G>A	c.(1423-1425)GCC>ACC	p.A475T	ATP1A1_uc010owv.1_Missense_Mutation_p.A444T|ATP1A1_uc010oww.1_Missense_Mutation_p.A475T|ATP1A1_uc010owx.1_Missense_Mutation_p.A444T|C1orf203_uc009whb.2_RNA	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	475	Cytoplasmic (Potential).			A -> T (in Ref. 12; CAA27390).	ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	AGAAAGATACGCCAAAATCGT	0.537		NaN											0	0	0	0.003163	0	14	109									
NOTCH2	4853	broad.mit.edu	37	1	120461054	120461054	+	Silent	SNP	C	C	T	rs149442704		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:120461054C>T	uc001eik.2	-	32	6160	c.5904G>A	c.(5902-5904)GCG>GCA	p.A1968A		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1968	Cytoplasmic (Potential).|ANK 4.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CATTCACATCCGCTTGGCAGT	0.527		NaN	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				0	0	0	0.001368	0	11	104									
NBPF10	100132406	broad.mit.edu	37	1	145293519	145293519	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:145293519C>G	uc001end.3	+	1	149	c.114C>G	c.(112-114)CTC>CTG	p.L38L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Silent_p.L38L|NOTCH2NL_uc010oyh.1_RNA|NBPF10_uc001emq.1_Silent_p.L38L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	38											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TCAGAAACCTCAAAGAGAAAT	0.473		NaN											0	0	0	0.00361	0	49	568									
TXNIP	10628	broad.mit.edu	37	1	145440314	145440314	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:145440314G>T	uc001enn.3	+	5	961	c.620G>T	c.(619-621)CGA>CTA	p.R207L	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Missense_Mutation_p.R152L	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	207					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ACATGTTCCCGAATTGTGGTC	0.453		NaN											1	0	1.43246e-33	0.007835	1.83193e-33	40	84									
ANKRD34A	284615	broad.mit.edu	37	1	145473774	145473774	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:145473774C>T	uc001enq.1	+	4	1739	c.446C>T	c.(445-447)TCG>TTG	p.S149L	NBPF10_uc001emp.3_Intron	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	149											0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ACCGATACCTCGCCCTCAGGC	0.652		NaN											0	0	0	0.008291	0	11	47									
BCL9	607	broad.mit.edu	37	1	147096327	147096327	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:147096327G>A	uc001epq.2	+	10	4588	c.3848G>A	c.(3847-3849)AGA>AAA	p.R1283K	BCL9_uc010ozr.1_Missense_Mutation_p.R1197K	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1283	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					CAAGCCCCCAGAATGGGACTA	0.587		NaN	T	IGH@|IGL@	B-ALL								0	0	0	0.004482	0	9	44									
HIST2H2BE	8349	broad.mit.edu	37	1	149858021	149858021	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:149858021G>A	uc001etc.2	-	1	212	c.170C>T	c.(169-171)TCC>TTC	p.S57F	HIST2H2AC_uc001etd.2_5'Flank	NM_003528	NP_003519	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	57					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CATGGCCTTGGACGAGATGCC	0.587		NaN											0	0	0	0.00361	0	82	172									
ANXA9	8416	broad.mit.edu	37	1	150960575	150960575	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:150960575C>T	uc001ewa.2	+	11	1176	c.706C>T	c.(706-708)CAG>TAG	p.Q236*		NM_003568	NP_003559	O76027	ANXA9_HUMAN	annexin A9	236	Annexin 3.				cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity				0	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGTGTTTGATCAGTACCAGCG	0.557		NaN											0	0	0	0.00333	0	20	48									
ZNF687	57592	broad.mit.edu	37	1	151261860	151261860	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:151261860C>T	uc001exq.2	+	5	2576	c.2478C>T	c.(2476-2478)ATC>ATT	p.I826I	ZNF687_uc009wmo.2_Silent_p.I826I|ZNF687_uc009wmp.2_Silent_p.I826I	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	826					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCAGGCTGATCTACAAGTGCG	0.622		NaN											0	0	0	0.002852	0	41	94									
ZNF687	57592	broad.mit.edu	37	1	151262612	151262612	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:151262612C>A	uc001exq.2	+	7	3077	c.2979C>A	c.(2977-2979)TTC>TTA	p.F993L	ZNF687_uc009wmo.2_Missense_Mutation_p.F993L|ZNF687_uc009wmp.2_Missense_Mutation_p.F993L	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	993	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGAAAAAGTTCCCCTGTCGCC	0.612		NaN											1	0	5.8336e-16	0.003271	7.33658e-16	14	95									
ZNF687	57592	broad.mit.edu	37	1	151262619	151262619	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:151262619C>A	uc001exq.2	+	7	3084	c.2986C>A	c.(2986-2988)CGC>AGC	p.R996S	ZNF687_uc009wmo.2_Missense_Mutation_p.R996S|ZNF687_uc009wmp.2_Missense_Mutation_p.R996S	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	996	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GTTCCCCTGTCGCCTGTGTGA	0.592		NaN											1	0	1.90571e-15	0.004289	2.39461e-15	13	94									
ZNF687	57592	broad.mit.edu	37	1	151262635	151262635	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:151262635C>T	uc001exq.2	+	7	3100	c.3002C>T	c.(3001-3003)TCC>TTC	p.S1001F	ZNF687_uc009wmo.2_Missense_Mutation_p.S1001F|ZNF687_uc009wmp.2_Missense_Mutation_p.S1001F	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	1001	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGTGAGCGCTCCTTCTGCTCC	0.597		NaN											0	0	0	0.003271	0	13	95									
ZNF687	57592	broad.mit.edu	37	1	151262637	151262637	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:151262637T>C	uc001exq.2	+	7	3102	c.3004T>C	c.(3004-3006)TTC>CTC	p.F1002L	ZNF687_uc009wmo.2_Missense_Mutation_p.F1002L|ZNF687_uc009wmp.2_Missense_Mutation_p.F1002L	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	1002	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGAGCGCTCCTTCTGCTCCGC	0.592		NaN											0	0	0	0.003755	0	13	96									
ZNF687	57592	broad.mit.edu	37	1	151263516	151263516	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:151263516C>G	uc001exq.2	+	9	3643	c.3545C>G	c.(3544-3546)TCA>TGA	p.S1182*	ZNF687_uc009wmo.2_Nonsense_Mutation_p.S1182*|ZNF687_uc009wmp.2_3'UTR	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	1182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GCCCCTCCATCAAGGTCTGAC	0.617		NaN											0	0	0	0.003954	0	24	59									
TCHHL1	126637	broad.mit.edu	37	1	152058710	152058710	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:152058710C>T	uc001ezo.1	-	3	1513	c.1448G>A	c.(1447-1449)AGC>AAC	p.S483N		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	483							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TGCGTTTTTGCTGTTCACAAA	0.483		NaN											0	0	0	0.00361	0	98	225									
LCE2B	26239	broad.mit.edu	37	1	152659594	152659594	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:152659594G>C	uc001fai.2	+	2	329	c.275G>C	c.(274-276)TGT>TCT	p.C92S		NM_014357	NP_055172	O14633	LCE2B_HUMAN	late cornified envelope 2B	92	Cys-rich.				keratinization					ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCGACTGCTGTGAGAGTGAA	0.632		NaN											0	0	0	0.003271	0	35	108									
ADAR	103	broad.mit.edu	37	1	154574803	154574803	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:154574803C>G	uc001ffh.2	-	2	515	c.315G>C	c.(313-315)CAG>CAC	p.Q105H	ADAR_uc001ffj.2_Missense_Mutation_p.Q105H|ADAR_uc001ffi.2_Missense_Mutation_p.Q105H|ADAR_uc001ffk.2_5'UTR|ADAR_uc001ffl.1_5'UTR|ADAR_uc001ffm.1_Intron|ADAR_uc001ffn.1_Intron	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	105					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GGAACCCTCTCTGGAGCCCCT	0.557		NaN											0	0	0	0.002836	0	34	61									
RAG1AP1	55974	broad.mit.edu	37	1	155109406	155109406	+	Silent	SNP	T	T	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:155109406T>C	uc001fhj.3	+	3	361	c.261T>C	c.(259-261)TAT>TAC	p.Y87Y	RAG1AP1_uc010pey.1_RNA|RAG1AP1_uc001fhk.3_Intron|RAG1AP1_uc001fhl.3_Silent_p.Y87Y	NM_018845	NP_061333	Q9BRV3	SWET1_HUMAN	recombination activating gene 1 activating	87	Helical; Name=3; (Potential).|MtN3/slv 1.				positive regulation of gene expression, epigenetic	Golgi membrane|integral to membrane|plasma membrane	glucoside transmembrane transporter activity				0	all_epithelial(22;4.71e-30)|all_lung(78;3.15e-27)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;2.28e-10)|all cancers(21;6.16e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000395)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCTTGGCATATCTGCATTACT	0.562		NaN											0	0	0	0.000602	0	5	78									
ASH1L	55870	broad.mit.edu	37	1	155313492	155313492	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:155313492C>T	uc009wqq.2	-	23	8518	c.8038G>A	c.(8038-8040)GAT>AAT	p.D2680N	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.D2675N	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2680	BAH.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GGGTGGCCATCAGGGGTGCGC	0.438		NaN											0	0	0	0.001984	0	7	64									
GON4L	54856	broad.mit.edu	37	1	155796774	155796774	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:155796774G>A	uc001flz.2	-	3	648	c.551C>T	c.(550-552)TCA>TTA	p.S184L	GON4L_uc001fly.1_Missense_Mutation_p.S184L|GON4L_uc009wrh.1_Missense_Mutation_p.S184L|GON4L_uc001fma.1_Missense_Mutation_p.S184L|GON4L_uc001fmc.2_Missense_Mutation_p.S184L|GON4L_uc001fmd.3_Missense_Mutation_p.S184L|GON4L_uc009wri.2_5'UTR|GON4L_uc001fme.2_Missense_Mutation_p.S12L	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	184					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TTGGCTGCCTGATGGCAGGGA	0.473		NaN											0	0	0	0.001855	0	13	72									
SEMA4A	64218	broad.mit.edu	37	1	156126258	156126258	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:156126258G>C	uc001fnl.2	+	3	297	c.193G>C	c.(193-195)GAC>CAC	p.D65H	SEMA4A_uc009wrq.2_Missense_Mutation_p.D65H|SEMA4A_uc001fnm.2_Missense_Mutation_p.D65H|SEMA4A_uc001fnn.2_5'UTR|SEMA4A_uc001fno.2_Missense_Mutation_p.D65H	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	65	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CCAGGATTTTGACACTCTGCT	0.542		NaN											0	0	0	0.008361	0	28	60									
BCAN	63827	broad.mit.edu	37	1	156617443	156617443	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:156617443G>C	uc001fpp.2	+	4	946	c.610G>C	c.(610-612)GAT>CAT	p.D204H	BCAN_uc001fpo.2_Missense_Mutation_p.D204H	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	204	Link 1.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGAGCAATGTGATGCTGGCTG	0.647		NaN											0	0	0	0.007413	0	17	122									
ARHGEF11	9826	broad.mit.edu	37	1	156912573	156912573	+	Splice_Site	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:156912573C>G	uc001fqo.2	-	32	4156	c.3116_splice	c.e32-1	p.D1039_splice	ARHGEF11_uc010phu.1_Splice_Site_p.D455_splice|ARHGEF11_uc001fqn.2_Splice_Site_p.D1079_splice	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11						actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCCCGTTTATCTGTGTGAGGA	0.542		NaN											0	0	0	0.006999	0	38	54									
FCRL5	83416	broad.mit.edu	37	1	157514314	157514314	+	Silent	SNP	C	C	T	rs112294248		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:157514314C>T	uc001fqu.2	-	5	740	c.582G>A	c.(580-582)CTG>CTA	p.L194L	FCRL5_uc009wsm.2_Silent_p.L194L|FCRL5_uc010phv.1_Silent_p.L194L|FCRL5_uc010phw.1_Silent_p.L109L|FCRL5_uc001fqv.1_Silent_p.L194L|FCRL5_uc010phx.1_5'UTR	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	194	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				AGCTGGCTCTCAGCACTGGAC	0.557		NaN											0	0	0	0.00623	0	35	71									
OR10J3	441911	broad.mit.edu	37	1	159284102	159284102	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:159284102G>A	uc010piu.1	-	1	348	c.348C>T	c.(346-348)CTC>CTT	p.L116L		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					CCATGACTGTGAGCAGGAAGC	0.507		NaN											0	0	0	0.004007	0	15	79									
ATP1A4	480	broad.mit.edu	37	1	160136489	160136489	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:160136489G>T	uc001fve.3	+	8	1698	c.1219G>T	c.(1219-1221)GAG>TAG	p.E407*	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_5'UTR	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	407	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GACCGTGTATGAGGCCGACAC	0.552		NaN											1	0	1.76689e-08	0.006214	2.15438e-08	10	71									
PVRL4	81607	broad.mit.edu	37	1	161046192	161046192	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:161046192G>C	uc001fxo.2	-	4	1103	c.804C>G	c.(802-804)CTC>CTG	p.L268L	PVRL4_uc010pjy.1_5'Flank|PVRL4_uc010pjz.1_Silent_p.L2L	NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4 precursor	268	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TCAGGCACTTGAGCATAGCTC	0.562		NaN											0	0	0	0.004482	0	9	49									
UHMK1	127933	broad.mit.edu	37	1	162468057	162468057	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:162468057C>T	uc001gcc.1	+	1	403	c.267C>T	c.(265-267)ATC>ATT	p.I89I	UHMK1_uc001gcb.1_Intron|UHMK1_uc009wuu.1_Silent_p.I89I	NM_175866	NP_787062	Q8TAS1	UHMK1_HUMAN	kinase interacting stathmin	89	Protein kinase.				cell cycle arrest|neuron projection development|peptidyl-serine phosphorylation|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus	axon|dendrite cytoplasm|neuronal RNA granule|nucleus	protein binding|protein serine/threonine kinase activity|ribonucleoprotein binding|RNA binding				0	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			ACAGAAACATCGGTAATTGCC	0.607		NaN											0	0	0	0.001168	0	4	22									
FAM78B	149297	broad.mit.edu	37	1	166039523	166039523	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:166039523C>T	uc001gdr.2	-	3	1331	c.741G>A	c.(739-741)TGG>TGA	p.W247*	FAM78B_uc010plc.1_RNA|FAM78B_uc001gdq.2_RNA	NM_001017961	NP_001017961	Q5VT40	FA78B_HUMAN	hypothetical protein LOC149297	247										central_nervous_system(1)|skin(1)	2	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					GCTTGGGCCTCCACATGAGGA	0.592		NaN											0	0	0	0.00333	0	24	106									
TADA1	117143	broad.mit.edu	37	1	166845422	166845422	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:166845422C>A	uc001gdw.2	-	1	233	c.49G>T	c.(49-51)GAG>TAG	p.E17*	TADA1_uc009wve.2_Nonsense_Mutation_p.E17*	NM_053053	NP_444281	Q96BN2	TADA1_HUMAN	transcriptional adaptor 1-like	17					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(1)	1						CCCAGGGCCTCGCTTAAGTTC	0.667		NaN											1	0	2.74318e-10	0.006214	3.39654e-10	9	47									
ADCY10	55811	broad.mit.edu	37	1	167871010	167871010	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:167871010C>T	uc001ger.2	-	5	624	c.326G>A	c.(325-327)CGA>CAA	p.R109Q	ADCY10_uc009wvk.2_Missense_Mutation_p.R17Q|ADCY10_uc010plj.1_Intron|ADCY10_uc009wvl.2_Missense_Mutation_p.R108Q|ADCY10_uc009wvm.2_Intron	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	109	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						CAGCTGCTTTCGCTCCACCCT	0.493		NaN											0	0	0	0.004656	0	26	140									
GPR161	23432	broad.mit.edu	37	1	168054780	168054780	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:168054780C>T	uc001gfc.2	-	8	1893	c.1579G>A	c.(1579-1581)GAG>AAG	p.E527K	GPR161_uc001gfb.2_Missense_Mutation_p.E395K|GPR161_uc010pll.1_Missense_Mutation_p.E437K|GPR161_uc010plm.1_Missense_Mutation_p.E413K|GPR161_uc009wvo.2_Missense_Mutation_p.E544K|GPR161_uc001gfd.2_Missense_Mutation_p.E527K|GPR161_uc010pln.1_Missense_Mutation_p.E547K	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	527	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					CATCTCTGCTCGGCAGCTAAA	0.667		NaN											0	0	0	0.004007	0	17	81									
FMO1	2326	broad.mit.edu	37	1	171251468	171251468	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:171251468G>C	uc009wvz.2	+	7	1315	c.1179G>C	c.(1177-1179)CTG>CTC	p.L393L	FMO1_uc010pme.1_Silent_p.L330L|FMO1_uc001ghl.2_Silent_p.L393L|FMO1_uc001ghm.2_Silent_p.L393L|FMO1_uc001ghn.2_Silent_p.L393L	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	393					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTCGAGTCCTGAAAGGTAAGT	0.448		NaN											0	0	0	0.001984	0	7	51									
ACBD6	84320	broad.mit.edu	37	1	180283851	180283851	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:180283851C>G	uc001gog.2	-	7	1291	c.670G>C	c.(670-672)GAA>CAA	p.E224Q		NM_032360	NP_115736	Q9BR61	ACBD6_HUMAN	acyl-coenzyme A binding domain containing 6	224	ANK 2.					cytoplasm|nucleus	fatty-acyl-CoA binding			ovary(1)	1						GTTTGGCCTTCATTGTCCTAT	0.239		NaN											0	0	0	0.000978	0	11	77									
C1orf14	81626	broad.mit.edu	37	1	182921966	182921966	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:182921966C>G	uc001gpu.2	-	1	588	c.303G>C	c.(301-303)GAG>GAC	p.E101D	C1orf14_uc001gpv.2_5'UTR|C1orf14_uc010pnz.1_5'UTR|C1orf14_uc001gpw.2_5'UTR	NM_030933	NP_112195	Q9BZQ2	SHP1L_HUMAN	chromosome 1 open reading frame 14	173											0				Colorectal(1306;1.64e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00267)		GCTGCGCCTCCTCTTCATCCT	0.602		NaN											0	0	0	0.000978	0	9	22									
TPR	7175	broad.mit.edu	37	1	186322927	186322927	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:186322927G>A	uc001grv.2	-	18	2524	c.2227C>T	c.(2227-2229)CAT>TAT	p.H743Y		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	743	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TTTCTCTCATGAAGTGATGTT	0.353		NaN	T	NTRK1	papillary thyroid								0	0	0	0.001368	0	13	98									
KCNT2	343450	broad.mit.edu	37	1	196251455	196251455	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:196251455G>C	uc001gtd.1	-	24	2789	c.2729C>G	c.(2728-2730)ACG>AGG	p.T910R	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.T836R|KCNT2_uc001gtf.1_Missense_Mutation_p.T886R|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.T886R|KCNT2_uc001gth.1_Missense_Mutation_p.T407R	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	910	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CAGAAGTCTCGTGATAGAAAT	0.303		NaN											0	0	0	0.00308	0	6	52									
CFHR1	3078	broad.mit.edu	37	1	196797272	196797272	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:196797272C>T	uc001gtn.2	+	4	617	c.503C>T	c.(502-504)TCT>TTT	p.S168F	CFHR1_uc001gtm.2_Missense_Mutation_p.S72F	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	168	Sushi 3.				complement activation	extracellular space					0						AAATATCCATCTGGTGAGAGA	0.413		NaN											0	0	0	0.006122	0	17	26									
DDX59	83479	broad.mit.edu	37	1	200617569	200617569	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:200617569G>C	uc009wzk.2	-	7	1837	c.1594C>G	c.(1594-1596)CAG>GAG	p.Q532E	DDX59_uc010ppl.1_Missense_Mutation_p.Q532E	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	532	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						CTCCTTACCTGATGGACATAC	0.398		NaN											0	0	0	0.00632	0	26	54									
KIF21B	23046	broad.mit.edu	37	1	200967564	200967564	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:200967564C>G	uc001gvs.1	-	14	2342	c.2025G>C	c.(2023-2025)CAG>CAC	p.Q675H	KIF21B_uc001gvr.1_Missense_Mutation_p.Q675H|KIF21B_uc009wzl.1_Missense_Mutation_p.Q675H|KIF21B_uc010ppn.1_Missense_Mutation_p.Q675H	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	675	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GGATCTTGTTCTGCAGCAGAA	0.582		NaN											0	0	0	0.001786	0	28	130									
ELF3	1999	broad.mit.edu	37	1	201981484	201981484	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:201981484C>T	uc001gxg.3	+	3	3590	c.398C>T	c.(397-399)TCT>TTT	p.S133F	ELF3_uc001gxi.3_Missense_Mutation_p.S133F|ELF3_uc001gxh.3_Missense_Mutation_p.S133F	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	133					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						TCCAGCTCTTCTGATGAGCTC	0.582		NaN											0	0	0	0.004656	0	24	132									
ELF3	1999	broad.mit.edu	37	1	201981809	201981809	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:201981809C>T	uc001gxg.3	+	4	3712	c.520C>T	c.(520-522)CAG>TAG	p.Q174*	ELF3_uc001gxi.3_Nonsense_Mutation_p.Q174*|ELF3_uc001gxh.3_Nonsense_Mutation_p.Q174*	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	174					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						GGACGACGGTCAGCAAGCCAG	0.667		NaN											0	0	0	0.004007	0	16	77									
LAX1	54900	broad.mit.edu	37	1	203734754	203734754	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:203734754C>G	uc001haa.2	+	1	471	c.61C>G	c.(61-63)CTG>GTG	p.L21V	LAX1_uc010pql.1_Intron	NM_017773	NP_060243	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1 isoform a	21	Extracellular (Potential).				B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)	2	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GTCCAGCACTCTGCATGTGAC	0.557		NaN											0	0	0	0.001984	0	6	36									
PIK3C2B	5287	broad.mit.edu	37	1	204438482	204438482	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:204438482G>C	uc001haw.2	-	3	928	c.449C>G	c.(448-450)TCT>TGT	p.S150C	PIK3C2B_uc010pqv.1_Missense_Mutation_p.S150C|PIK3C2B_uc001hax.1_Missense_Mutation_p.S150C|PIK3C2B_uc009xbd.1_RNA	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	150	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			TTTCTTGCAAGAGCCCTCTAT	0.577		NaN											0	0	0	0.001168	0	6	68									
NFASC	23114	broad.mit.edu	37	1	204942505	204942505	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:204942505G>A	uc001hbj.2	+	12	1565	c.1237G>A	c.(1237-1239)GAG>AAG	p.E413K	NFASC_uc001hbh.2_Missense_Mutation_p.E413K|NFASC_uc010pqz.1_Missense_Mutation_p.E407K|NFASC_uc010pra.1_Missense_Mutation_p.E424K|NFASC_uc001hbi.2_Missense_Mutation_p.E424K|NFASC_uc009xbg.1_Missense_Mutation_p.E497K|NFASC_uc010prb.1_Missense_Mutation_p.E424K|NFASC_uc010prc.1_5'UTR|NFASC_uc001hbk.1_Missense_Mutation_p.E234K	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	413	Extracellular (Potential).|Ig-like C2-type 4.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CACCTCCAACGAGCATGGCTA	0.607		NaN											0	0	0	0.004007	0	16	37									
ELK4	2005	broad.mit.edu	37	1	205589767	205589767	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:205589767G>T	uc001hcy.1	-	3	1657	c.407C>A	c.(406-408)TCT>TAT	p.S136Y	ELK4_uc001hcz.2_Missense_Mutation_p.S136Y	NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a	136						cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			ATTGCGGCTAGAGGTCTTGGC	0.418		NaN	T	SLC45A3	prostate								1	0	2.74318e-10	0.006214	3.39654e-10	10	107									
SLC45A3	85414	broad.mit.edu	37	1	205628644	205628644	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:205628644G>C	uc001hda.1	-	5	1719	c.1380C>G	c.(1378-1380)CTC>CTG	p.L460L	SLC45A3_uc010prn.1_Intron|SLC45A3_uc010pro.1_Intron|SLC45A3_uc010prp.1_Intron|ELK4_uc010prq.1_Intron	NM_033102	NP_149093	Q96JT2	S45A3_HUMAN	prostein	460					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)	ovary(2)|prostate(2)	4	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			AGGCCCCGCAGAGCGCGGGTG	0.677		NaN	T	ETV1|ETV5|ELK4|ERG	prostate 						OREG0014161	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	24									
SLC26A9	115019	broad.mit.edu	37	1	205892252	205892252	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:205892252C>T	uc001hdq.2	-	16	1845	c.1731G>A	c.(1729-1731)ATG>ATA	p.M577I	SLC26A9_uc001hdo.2_Missense_Mutation_p.M245I|SLC26A9_uc001hdp.2_Missense_Mutation_p.M577I	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	577	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			GTGTGGGCCTCATTCTCCGCT	0.522		NaN											0	0	0	0.003954	0	23	101									
IKBKE	9641	broad.mit.edu	37	1	206652436	206652436	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:206652436C>G	uc001hdz.1	+	10	1511	c.1143C>G	c.(1141-1143)CTC>CTG	p.L381L	IKBKE_uc009xbv.1_Silent_p.L381L|IKBKE_uc001hea.1_Silent_p.L296L	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon	381					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)					CCCTGACCCTCTTCAGCACAG	0.607		NaN											0	0	0	0.004007	0	17	43									
LGTN	1939	broad.mit.edu	37	1	206772966	206772966	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:206772966C>T	uc001heh.2	-	10	1262	c.1053G>A	c.(1051-1053)AGG>AGA	p.R351R	LGTN_uc009xbw.2_Silent_p.R227R	NM_006893	NP_008824	P41214	EIF2D_HUMAN	ligatin	351					intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			AAGATGTAATCCTAAAACCCA	0.532		NaN											0	0	0	0.00245	0	13	76									
IRF6	3664	broad.mit.edu	37	1	209974644	209974644	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:209974644G>C	uc001hhq.1	-	3	378	c.115C>G	c.(115-117)CCC>GCC	p.P39A	IRF6_uc010psm.1_Intron|IRF6_uc009xct.1_Missense_Mutation_p.P39A	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	39	IRF tryptophan pentad repeat.		P -> A (in VWS).		cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		TGTTTCCAGGGAATCTGGAAG	0.512		NaN								HNSCC(57;0.16)			0	0	0	0.004007	0	15	120									
IRF6	3664	broad.mit.edu	37	1	209974759	209974759	+	Translation_Start_Site	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:209974759G>C	uc001hhq.1	-	3	263	c.0C>G	c.(-2-2)ATCAT>ATGAT		IRF6_uc010psm.1_Intron|IRF6_uc009xct.1_Translation_Start_Site	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6						cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		GGAGGGCCATGATCTGGGGGG	0.592		NaN								HNSCC(57;0.16)			0	0	0	0.008291	0	9	98									
SMYD2	56950	broad.mit.edu	37	1	214505378	214505378	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:214505378G>A	uc010ptx.1	+	10	988	c.955G>A	c.(955-957)GAG>AAG	p.E319K	SMYD2_uc009xdj.2_3'UTR|SMYD2_uc010ptw.1_RNA|SMYD2_uc009xdl.1_Intron	NM_020197	NP_064582	Q9NRG4	SMYD2_HUMAN	SET and MYND domain containing 2	319					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	cytosol|nucleus	histone methyltransferase activity (H3-K36 specific)|p53 binding|RNA polymerase II core binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0122)|all cancers(67;0.0209)|GBM - Glioblastoma multiforme(131;0.106)|Epithelial(68;0.144)		TGAGCTGCTGGAGATCTGCGA	0.562		NaN									OREG0012979	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	38									
DUSP10	11221	broad.mit.edu	37	1	221876002	221876002	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:221876002C>G	uc001hmy.1	-	4	1383	c.1201G>C	c.(1201-1203)GGG>CGG	p.G401R	DUSP10_uc001hmx.1_Missense_Mutation_p.G59R|DUSP10_uc001hmz.1_Missense_Mutation_p.G59R	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	401	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		AGCCCCTTCCCACACTGGTGA	0.522		NaN											0	0	0	0.003163	0	14	42									
MIA3	375056	broad.mit.edu	37	1	222826446	222826446	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:222826446C>T	uc001hnl.2	+	14	4192	c.4183C>T	c.(4183-4185)CTT>TTT	p.L1395F	MIA3_uc009xea.1_Missense_Mutation_p.L1172F|MIA3_uc001hnm.2_Missense_Mutation_p.L273F	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1395	Potential.|Cytoplasmic (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		GGAAGTAGCTCTTACTCACAA	0.348		NaN											0	0	0	0.000248	0	4	48									
CABC1	56997	broad.mit.edu	37	1	227149128	227149128	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:227149128C>T	uc001hqm.1	+	7	3461	c.42C>T	c.(40-42)GGC>GGT	p.G14G	CABC1_uc010pvp.1_5'UTR|CABC1_uc001hqn.1_Silent_p.G14G|CABC1_uc009xeq.1_Intron|CABC1_uc010pvq.1_Intron	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	14					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				TGGCTAAAGGCCTTGTCAAGC	0.642		NaN											0	0	0	0.001168	0	6	92									
SNAP47	116841	broad.mit.edu	37	1	227923158	227923158	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:227923158G>A	uc001hrf.2	+	1	462	c.48G>A	c.(46-48)CCG>CCA	p.P16P	SNAP47_uc001hqz.2_Intron|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_Silent_p.P16P|SNAP47_uc001hre.2_5'UTR|JMJD4_uc001hrc.2_5'Flank|JMJD4_uc001hrb.2_5'Flank	NM_053052	NP_444280	Q5SQN1	SNP47_HUMAN	synaptosomal-associated protein, 47kDa	16						endomembrane system|membrane|perinuclear region of cytoplasm				ovary(1)	1						CCGAGCGGCCGAGGCGCCGCG	0.761		NaN											0	0	0	0.004672	0	3	5									
C1orf35	79169	broad.mit.edu	37	1	228290054	228290054	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:228290054C>G	uc001hrx.2	-	5	498	c.404G>C	c.(403-405)CGA>CCA	p.R135P	C1orf35_uc009xew.2_RNA	NM_024319	NP_077295	Q9BU76	MMTA2_HUMAN	hypothetical protein LOC79169	135											0		Prostate(94;0.0488)				CTTGTCCTCTCGGGACATCGC	0.692		NaN											0	0	0	0.000602	0	4	18									
PCNXL2	80003	broad.mit.edu	37	1	233314877	233314877	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:233314877G>A	uc001hvl.2	-	16	3346	c.3111C>T	c.(3109-3111)TTC>TTT	p.F1037F	PCNXL2_uc001hvm.1_RNA|PCNXL2_uc009xfu.2_RNA|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1037	Helical; (Potential).					integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				AGAGGCCACAGAAGGCCGAAA	0.512		NaN											0	0	0	0.001368	0	10	57									
IRF2BP2	359948	broad.mit.edu	37	1	234744657	234744657	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:234744657G>A	uc001hwg.2	-	1	615	c.584C>T	c.(583-585)TCG>TTG	p.S195L	IRF2BP2_uc009xfw.2_5'Flank|IRF2BP2_uc001hwf.2_Missense_Mutation_p.S195L	NM_182972	NP_892017	Q7Z5L9	I2BP2_HUMAN	interferon regulatory factor 2 binding protein 2	195	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Ovarian(103;0.0303)	all_cancers(173;0.0236)|Prostate(94;0.0115)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)|Epithelial(3;6.2e-05)			CGGCGTGGCCGAGCCGTTCAT	0.766		NaN											0	0	0	0.001984	0	7	15									
RYR2	6262	broad.mit.edu	37	1	237819236	237819236	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:237819236C>T	uc001hyl.1	+	53	8201	c.8081C>T	c.(8080-8082)TCA>TTA	p.S2694L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2694	Modulator (Potential).|Cytoplasmic (By similarity).|3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAACAGTCATCAATGGATTCT	0.413		NaN											0	0	0	0.008291	0	10	23									
CNST	163882	broad.mit.edu	37	1	246811273	246811273	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:246811273G>A	uc001ibp.2	+	9	2148	c.1770G>A	c.(1768-1770)GAG>GAA	p.E590E	CNST_uc001ibo.3_Silent_p.E590E	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	590					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						GTCTCCAGGAGAATCTGCCTT	0.403		NaN											0	0	0	0.001786	0	31	85									
SCCPDH	51097	broad.mit.edu	37	1	246923504	246923504	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:246923504C>G	uc001ibr.2	+	9	1312	c.965C>G	c.(964-966)TCA>TGA	p.S322*		NM_016002	NP_057086	Q8NBX0	SCPDH_HUMAN	saccharopine dehydrogenase (putative)	322						midbody	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity			ovary(1)	1	all_cancers(71;6.8e-05)|all_epithelial(71;7.93e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0545)|Lung NSC(105;0.0618)	all_cancers(173;0.0343)	OV - Ovarian serous cystadenocarcinoma(106;0.00323)	GBM - Glioblastoma multiforme(49;0.0896)		GGCTATTTTTCAAAACAAGGC	0.299		NaN											0	0	0	0.005443	0	23	38									
OR6F1	343169	broad.mit.edu	37	1	247875277	247875277	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:247875277G>A	uc001idj.1	-	1	781	c.781C>T	c.(781-783)CGC>TGC	p.R261C		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			ATAGAGGTGCGGACGTGAAGG	0.522		NaN											0	0	0	0.00245	0	15	71									
OR2T12	127064	broad.mit.edu	37	1	248458107	248458107	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:248458107C>T	uc010pzj.1	-	1	774	c.774G>A	c.(772-774)ATG>ATA	p.M258I		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	258	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ATTTGGGTCTCATATAGGTAA	0.483		NaN											0	0	0	0.003954	0	27	126									
OPTN	10133	broad.mit.edu	37	10	13154581	13154581	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:13154581C>G	uc001ilu.1	+	6	936	c.498C>G	c.(496-498)CTC>CTG	p.L166L	OPTN_uc001ilv.1_Silent_p.L166L|OPTN_uc001ilw.1_Silent_p.L166L|OPTN_uc001ilx.1_Silent_p.L166L|OPTN_uc001ily.1_Silent_p.L166L|OPTN_uc010qbr.1_Silent_p.L109L|OPTN_uc001ilz.1_Silent_p.L166L	NM_001008213	NP_001008214	Q96CV9	OPTN_HUMAN	optineurin	166	Interaction with Rab8.|Potential.				cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			ovary(2)	2						AACTGCAGCTCAAGCTGAACT	0.498		NaN											0	0	0	0.002096	0	28	88									
ACBD7	414149	broad.mit.edu	37	10	15121001	15121001	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:15121001C>T	uc001inv.2	-	2	99	c.51G>A	c.(49-51)CTG>CTA	p.L17L	ACBD7_uc010qby.1_5'UTR	NM_001039844	NP_001034933	Q8N6N7	ACBD7_HUMAN	acyl-Coenzyme A binding domain containing 7	17	ACB.						fatty-acyl-CoA binding				0						GTCTTGCTTTCAGCTTCCTCA	0.358		NaN											0	0	0	0.007835	0	33	93									
MLLT10	8028	broad.mit.edu	37	10	22002839	22002839	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:22002839C>T	uc001iqs.2	+	15	2234	c.1886C>T	c.(1885-1887)TCA>TTA	p.S629L	MLLT10_uc001iqt.2_Missense_Mutation_p.S613L|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.S613L|MLLT10_uc001ira.2_Missense_Mutation_p.S70L|MLLT10_uc001irb.2_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	629	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						CTCTCTCCCTCAGCTGTGTCA	0.473		NaN	T	MLL|PICALM|CDK6	AL								0	0	0	0.001523	0	20	78									
C10orf67	256815	broad.mit.edu	37	10	23611391	23611391	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:23611391C>G	uc010qcx.1	-	3	472	c.406G>C	c.(406-408)GAG>CAG	p.E136Q		NM_153714	NP_714925	Q8IYJ2	CJ067_HUMAN	hypothetical protein LOC256815	136											0						AAAGATTCCTCTTTCAGTCGG	0.328		NaN											0	0	0	0.006122	0	16	103									
SVIL	6840	broad.mit.edu	37	10	29820964	29820964	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:29820964G>T	uc001iut.1	-	9	2729	c.1976C>A	c.(1975-1977)CCT>CAT	p.P659H	SVIL_uc001iuu.1_Intron	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	659					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TGAAGTTATAGGTTGGGTTCT	0.488		NaN											1	0	1.15919e-05	0.008871	1.39568e-05	18	139									
ZNF33A	7581	broad.mit.edu	37	10	38306269	38306269	+	Missense_Mutation	SNP	G	G	A	rs582502		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:38306269G>A	uc001izh.2	+	4	383	c.205G>A	c.(205-207)GAG>AAG	p.E69K	ZNF33A_uc001izg.2_Missense_Mutation_p.E69K|ZNF33A_uc010qev.1_Missense_Mutation_p.E76K|ZNF33A_uc001izi.1_Missense_Mutation_p.E69K|ZNF33A_uc001izj.2_RNA	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	69	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						ACAAGGAGAAGAGCCATGGAA	0.433		NaN											0	0	0	0.00361	0	54	143									
ZNF33B	7582	broad.mit.edu	37	10	43089326	43089326	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:43089326G>A	uc001jaf.1	-	5	1187	c.1072C>T	c.(1072-1074)CAA>TAA	p.Q358*	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Nonsense_Mutation_p.Q246*|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	358	C2H2-type 2.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGATTACATTGAAAGTGTTTC	0.418		NaN											0	0	0	0.007835	0	42	104									
RET	5979	broad.mit.edu	37	10	43601965	43601965	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:43601965G>A	uc001jal.2	+	5	1199	c.1009G>A	c.(1009-1011)GAG>AAG	p.E337K	RET_uc001jak.1_Missense_Mutation_p.E337K|RET_uc010qez.1_Missense_Mutation_p.E83K	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	337	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	CTGGCCCAACGAGACCTCGGT	0.652		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				0	0	0	0.008291	0	11	20									
ALOX5	240	broad.mit.edu	37	10	45877975	45877975	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:45877975C>T	uc001jce.2	+	2	294	c.195C>T	c.(193-195)ATC>ATT	p.I65I	ALOX5_uc009xmt.2_Silent_p.I65I|ALOX5_uc010qfg.1_Silent_p.I65I	NM_000698	NP_000689	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	65	PLAT.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			ovary(1)|pancreas(1)	2		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	TGGGCGAGATCCAGCTGGTCA	0.547		NaN											0	0	0	0.007413	0	17	53									
ERCC6	2074	broad.mit.edu	37	10	50690842	50690842	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:50690842G>C	uc001jhs.3	-	10	2214	c.2060C>G	c.(2059-2061)TCG>TGG	p.S687W	ERCC6_uc010qgr.1_Missense_Mutation_p.S57W|ERCC6_uc001jhr.3_Missense_Mutation_p.S87W	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	687	Helicase ATP-binding.		S -> L (in CSB).		base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						GTCAAAGAGCGACCACAGCTC	0.483		NaN						Direct_reversal_of_damage|NER					0	0	0	0.004878	0	35	64									
TFAM	7019	broad.mit.edu	37	10	60145995	60145995	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:60145995G>A	uc001jkf.2	+	2	249	c.117G>A	c.(115-117)CCG>CCA	p.P39P	TFAM_uc001jkg.2_RNA|TFAM_uc001jkh.2_Silent_p.P39P	NM_003201	NP_003192	Q00059	TFAM_HUMAN	transcription factor A, mitochondrial precursor	39					DNA-dependent DNA replication|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase I promoter|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	mitochondrial light strand promoter sense binding|protein binding|sequence-specific DNA binding transcription factor activity				0						TGTATTTACCGAGGTGGTTTT	0.338		NaN											0	0	0	0.007291	0	27	70									
MYPN	84665	broad.mit.edu	37	10	69926110	69926110	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:69926110G>A	uc001jnm.3	+	11	1845	c.1660G>A	c.(1660-1662)GCA>ACA	p.A554T	MYPN_uc001jnl.1_Missense_Mutation_p.A554T|MYPN_uc001jnn.3_Missense_Mutation_p.A279T|MYPN_uc001jno.3_Missense_Mutation_p.A554T|MYPN_uc009xps.2_Missense_Mutation_p.A554T|MYPN_uc009xpt.2_Missense_Mutation_p.A554T|MYPN_uc010qit.1_Missense_Mutation_p.A260T|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	554						nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						CACCAACCTGGCAGCTATTGA	0.552		NaN											0	0	0	0.001855	0	11	56									
TET1	80312	broad.mit.edu	37	10	70412289	70412289	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:70412289G>A	uc001jok.3	+	6	4904	c.4399G>A	c.(4399-4401)GAA>AAA	p.E1467K		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1467					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						AATAAGGATAGAAATAGTAGT	0.363		NaN											0	0	0	0.00278	0	19	46									
TET1	80312	broad.mit.edu	37	10	70412337	70412337	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:70412337C>G	uc001jok.3	+	6	4952	c.4447C>G	c.(4447-4449)CCA>GCA	p.P1483A		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1483					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TCATGGGTGTCCAATTGCTAA	0.348		NaN											0	0	0	0.001855	0	12	46									
DDX21	9188	broad.mit.edu	37	10	70719870	70719870	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:70719870G>A	uc001jov.1	+	2	486	c.396G>A	c.(394-396)AAG>AAA	p.K132K	DDX21_uc001jow.1_Silent_p.K64K	NM_004728	NP_004719	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	132						nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3						AGCCCAAGAAGATGAAGAAAG	0.408		NaN											0	0	0	0.008291	0	11	42									
FUT11	170384	broad.mit.edu	37	10	75532615	75532615	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:75532615C>G	uc001jva.2	+	1	567	c.524C>G	c.(523-525)TCG>TGG	p.S175W	FUT11_uc001juy.1_Missense_Mutation_p.S175W|FUT11_uc001juz.1_Missense_Mutation_p.S175W	NM_173540	NP_775811	Q495W5	FUT11_HUMAN	fucosyltransferase 11 (alpha (1,3)	175	Lumenal (Potential).				protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity				0	Prostate(51;0.0112)					AGTCGCCACTCGGATTACCCG	0.687		NaN											0	0	0	0.006122	0	16	36									
DUPD1	338599	broad.mit.edu	37	10	76803619	76803619	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:76803619G>C	uc001jwq.1	-	2	357	c.357C>G	c.(355-357)TTC>TTG	p.F119L		NM_001003892	NP_001003892	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase	119	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)	2	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CACTGAGGTCGAAGGTGGGCA	0.577		NaN											0	0	0	0.007413	0	18	68									
PAPSS2	9060	broad.mit.edu	37	10	89501082	89501082	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:89501082C>T	uc001kex.2	+	9	1425	c.1162C>T	c.(1162-1164)CTG>TTG	p.L388L	PAPSS2_uc001kew.2_Silent_p.L393L	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	388	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		CCAATACCGTCTGACACCTCT	0.378		NaN											0	0	0	0.006214	0	9	76									
IFIT3	3437	broad.mit.edu	37	10	91099478	91099478	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:91099478G>A	uc001kgf.2	+	2	1295	c.1066G>A	c.(1066-1068)GAA>AAA	p.E356K	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron|IFIT3_uc001kgg.2_Missense_Mutation_p.E356K	NM_001549	NP_001540	O14879	IFIT3_HUMAN	interferon-induced protein with	356					type I interferon-mediated signaling pathway		protein binding			central_nervous_system(1)	1						CCCTGATGCTGAAAAGCAACA	0.453		NaN											0	0	0	0.003954	0	27	38									
CPN1	1369	broad.mit.edu	37	10	101841262	101841262	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:101841262C>G	uc001kql.2	-	1	381	c.121G>C	c.(121-123)GAA>CAA	p.E41Q		NM_001308	NP_001299	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1 precursor	41	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		CCGGGGCATTCGTTTTGCACC	0.597		NaN											0	0	0	0.001882	0	21	36									
PKD2L1	9033	broad.mit.edu	37	10	102089772	102089772	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:102089772G>A	uc001kqx.1	-	1	472	c.89C>T	c.(88-90)TCC>TTC	p.S30F	PKD2L1_uc009xwm.1_5'UTR	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	30	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		CCCGTGTGGGGAAGGGGGACC	0.622		NaN											0	0	0	0.002222	0	39	80									
CNNM2	54805	broad.mit.edu	37	10	104678701	104678701	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:104678701C>G	uc001kwm.2	+	1	588	c.464C>G	c.(463-465)TCA>TGA	p.S155*	CNNM2_uc001kwn.2_Nonsense_Mutation_p.S155*|CNNM2_uc001kwl.2_Nonsense_Mutation_p.S155*	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	155					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ATCCGCACCTCAGACATCATC	0.502		NaN											0	0	0	0.004656	0	28	196									
CNNM2	54805	broad.mit.edu	37	10	104816644	104816644	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:104816644G>A	uc001kwm.2	+	4	2120	c.1996G>A	c.(1996-1998)GAG>AAG	p.E666K	CNNM2_uc001kwn.2_Missense_Mutation_p.E666K	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	666					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GAAATATGATGAGAAGAACAA	0.433		NaN											0	0	0	0.005524	0	35	98									
ABLIM1	3983	broad.mit.edu	37	10	116307536	116307536	+	Splice_Site	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:116307536C>G	uc010qsg.1	-	5	773	c.674_splice	c.e5-1	p.N225_splice	ABLIM1_uc010qsh.1_Splice_Site_p.N165_splice|ABLIM1_uc010qsi.1_Splice_Site_p.N165_splice|ABLIM1_uc010qsk.1_Splice_Site_p.N149_splice|ABLIM1_uc009xyp.2_Splice_Site_p.N159_splice|ABLIM1_uc009xyo.2_Splice_Site_p.N73_splice	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a						axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		CCGGCACAATCTGAAAAAGAG	0.522		NaN											0	0	0	0.004482	0	8	32									
INPP5F	22876	broad.mit.edu	37	10	121586615	121586615	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:121586615C>G	uc001leo.2	+	20	2888	c.2722C>G	c.(2722-2724)CTT>GTT	p.L908V	INPP5F_uc001lep.2_Missense_Mutation_p.L298V	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	908							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		GTCCCAGTCTCTTAGCAGCAC	0.488		NaN											0	0	0	0.001855	0	14	68									
TACC2	10579	broad.mit.edu	37	10	123844900	123844900	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:123844900C>G	uc001lfv.2	+	4	3245	c.2885C>G	c.(2884-2886)TCG>TGG	p.S962W	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.S962W|TACC2_uc010qtv.1_Missense_Mutation_p.S962W	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	962						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TCGAGGGTCTCGCCTCCAGCA	0.537		NaN											0	0	0	0.002836	0	34	78									
DMBT1	1755	broad.mit.edu	37	10	124380654	124380654	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:124380654C>T	uc001lgk.1	+	41	5085	c.4979C>T	c.(4978-4980)TCC>TTC	p.S1660F	DMBT1_uc001lgl.1_Missense_Mutation_p.S1650F|DMBT1_uc001lgm.1_Missense_Mutation_p.S1032F|DMBT1_uc009xzz.1_Missense_Mutation_p.S1660F|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yab.1_Missense_Mutation_p.S363F|DMBT1_uc009yac.1_5'UTR	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1660	SRCR 13.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TATCGAGGCTCCTGGGGAACC	0.587		NaN											0	0	0	0.00361	0	101	231									
DMBT1	1755	broad.mit.edu	37	10	124390773	124390773	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:124390773G>A	uc001lgk.1	+	46	6041	c.5935G>A	c.(5935-5937)GAA>AAA	p.E1979K	DMBT1_uc001lgl.1_Missense_Mutation_p.E1969K|DMBT1_uc001lgm.1_Missense_Mutation_p.E1351K|DMBT1_uc009xzz.1_Missense_Mutation_p.E1979K|DMBT1_uc010qtx.1_Missense_Mutation_p.E699K|DMBT1_uc009yab.1_Missense_Mutation_p.E682K|DMBT1_uc009yac.1_Missense_Mutation_p.E273K	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1979	SRCR 14.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TAATCATCGTGAAGATGCTGG	0.537		NaN											0	0	0	0.003271	0	30	139									
DHX32	55760	broad.mit.edu	37	10	127542652	127542652	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:127542652C>T	uc001ljf.1	-	4	1461	c.970G>A	c.(970-972)GAA>AAA	p.E324K	DHX32_uc001lje.1_5'UTR|DHX32_uc001ljg.1_Missense_Mutation_p.E324K|DHX32_uc009yam.1_Intron	NM_018180	NP_060650	Q7L7V1	DHX32_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32	324						mitochondrion|nucleus	ATP binding|helicase activity			breast(2)|ovary(1)|lung(1)	4		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TTTTCTGTTTCATCGAGTGGC	0.388		NaN											0	0	0	0.00245	0	13	106									
MKI67	4288	broad.mit.edu	37	10	129903899	129903899	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:129903899C>G	uc001lke.2	-	13	6400	c.6205G>C	c.(6205-6207)GAG>CAG	p.E2069Q	MKI67_uc001lkf.2_Missense_Mutation_p.E1709Q|MKI67_uc009yav.1_Missense_Mutation_p.E1644Q|MKI67_uc009yaw.1_Missense_Mutation_p.E1219Q	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2069	16 X 122 AA approximate repeats.|9.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GATTGGGCCTCTTCCTTAGGT	0.483		NaN											0	0	0	0.00361	0	64	320									
MKI67	4288	broad.mit.edu	37	10	129904445	129904445	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:129904445C>G	uc001lke.2	-	13	5854	c.5659G>C	c.(5659-5661)GAG>CAG	p.E1887Q	MKI67_uc001lkf.2_Missense_Mutation_p.E1527Q|MKI67_uc009yav.1_Missense_Mutation_p.E1462Q|MKI67_uc009yaw.1_Missense_Mutation_p.E1037Q	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1887	16 X 122 AA approximate repeats.|8.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				AATTCTTCCTCTACGTCTGCT	0.458		NaN											0	0	0	0.00874	0	42	346									
CDHR5	53841	broad.mit.edu	37	11	618014	618014	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:618014G>A	uc001lqj.2	-	14	2163	c.2058C>T	c.(2056-2058)CTC>CTT	p.L686L	IRF7_uc009ycb.2_5'Flank|IRF7_uc010qwf.1_5'Flank|IRF7_uc001lqf.2_5'Flank|IRF7_uc010qwg.1_5'Flank|IRF7_uc001lqg.2_5'Flank|IRF7_uc001lqh.2_5'Flank|IRF7_uc001lqi.2_5'Flank|IRF7_uc010qwh.1_5'Flank|CDHR5_uc001lqk.2_Silent_p.L492L|CDHR5_uc009ycc.2_Silent_p.L520L|CDHR5_uc009ycd.2_Silent_p.L680L|CDHR5_uc001lql.2_Silent_p.L686L	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	686	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						CAAGGACGGCGAGGCCAAGGA	0.682		NaN											0	0	0	0.001984	0	7	27									
MUC5B	727897	broad.mit.edu	37	11	1157932	1157932	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:1157932C>G	uc009ycr.1	+	9	1125	c.999C>G	c.(997-999)TTC>TTG	p.F333L		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCCCTGACTTCTGCCGTGAGT	0.687		NaN											0	0	0	0.006214	0	8	47									
TRIM3	10612	broad.mit.edu	37	11	6470362	6470362	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:6470362C>T	uc001mdh.2	-	13	2518	c.2131G>A	c.(2131-2133)GAA>AAA	p.E711K	TRIM3_uc001mdi.2_Missense_Mutation_p.E711K|TRIM3_uc010raj.1_Missense_Mutation_p.E592K|TRIM3_uc009yfd.2_Missense_Mutation_p.E711K	NM_006458	NP_006449	O75382	TRIM3_HUMAN	tripartite motif-containing 3	711	NHL 6.				nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			central_nervous_system(2)|large_intestine(1)|ovary(1)|skin(1)	5		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TACAGTGGTTCTGCAGATGTG	0.547		NaN											0	0	0	0.008871	0	18	40									
DNHD1	144132	broad.mit.edu	37	11	6592126	6592126	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:6592126C>T	uc001mdw.3	+	42	13948	c.13384C>T	c.(13384-13386)CGC>TGC	p.R4462C	DNHD1_uc001mea.3_Missense_Mutation_p.R731C|DNHD1_uc001meb.2_3'UTR|DNHD1_uc001mec.2_Missense_Mutation_p.R730C|DNHD1_uc010rao.1_Missense_Mutation_p.R720C|DNHD1_uc009yfg.2_Missense_Mutation_p.R87C	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4462					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CCACGTGATTCGCCAAGACGA	0.627		NaN											0	0	0	0.00499	0	18	42									
IPO7	10527	broad.mit.edu	37	11	9435956	9435956	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:9435956C>T	uc001mho.2	+	5	776	c.634C>T	c.(634-636)CAG>TAG	p.Q212*		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	212					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TGCTCTTGTTCAGGTAATATC	0.343		NaN											0	0	0	0.006214	0	8	71									
SBF2	81846	broad.mit.edu	37	11	9838482	9838482	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:9838482G>A	uc001mib.2	-	29	4021	c.3883C>T	c.(3883-3885)CAC>TAC	p.H1295Y	SBF2_uc001mid.2_5'UTR	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1295	Myotubularin phosphatase.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		GAGGCCGAGTGATCCTTGCCT	0.507		NaN											0	0	0	0.001368	0	13	59									
SBF2	81846	broad.mit.edu	37	11	10014566	10014566	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:10014566G>A	uc001mib.2	-	11	1276	c.1138C>T	c.(1138-1140)CAT>TAT	p.H380Y	SBF2_uc001mif.3_Missense_Mutation_p.H136Y	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	380	dDENN.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		GGCTCTGCATGAATTCTTATA	0.318		NaN											0	0	0	0.003271	0	32	81									
MICALCL	84953	broad.mit.edu	37	11	12341262	12341262	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:12341262C>T	uc001mkg.1	+	4	1737	c.1446C>T	c.(1444-1446)CTC>CTT	p.L482L		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	482					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		ACTTTCCCCTCAGAGCACAGG	0.468		NaN											0	0	0	0.002445	0	32	111									
BTBD10	84280	broad.mit.edu	37	11	13435141	13435141	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:13435141C>T	uc001mkz.2	-	6	1001	c.744G>A	c.(742-744)CTG>CTA	p.L248L	BTBD10_uc010rcl.1_Silent_p.L256L|BTBD10_uc001mla.2_Silent_p.L232L|BTBD10_uc009ygn.2_RNA|BTBD10_uc010rcm.1_Silent_p.L200L|BTBD10_uc010rcn.1_Silent_p.L217L|BTBD10_uc009ygo.2_Silent_p.L200L	NM_032320	NP_115696	Q9BSF8	BTBDA_HUMAN	K+ channel tetramerization protein	248						nucleus					0				Epithelial(150;0.0214)		ATGCTTCTCTCAGTTCAGGAA	0.328		NaN											0	0	0	0.00308	0	8	61									
HPS5	11234	broad.mit.edu	37	11	18309162	18309162	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:18309162G>A	uc001mod.1	-	18	2915	c.2637C>T	c.(2635-2637)ATC>ATT	p.I879I	HPS5_uc001moe.1_Silent_p.I765I|HPS5_uc001mof.1_Silent_p.I765I	NM_181507	NP_852608	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5 isoform a	879						cytosol				ovary(1)|pancreas(1)|skin(1)	3						AAAGTTGTATGATATCCGATG	0.393		NaN							Hermansky-Pudlak_syndrome				0	0	0	0.007413	0	20	50									
MUC15	143662	broad.mit.edu	37	11	26584757	26584757	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:26584757G>C	uc001mqx.2	-	3	1016	c.750C>G	c.(748-750)GTC>GTG	p.V250V	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Silent_p.V277V|MUC15_uc001mqy.2_Intron	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	250	Helical; (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TAAGCAATGAGACACCCAGAA	0.343		NaN											0	0	0	0.002096	0	26	63									
CCDC73	493860	broad.mit.edu	37	11	32636042	32636042	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:32636042G>T	uc001mtv.2	-	16	1866	c.1822C>A	c.(1822-1824)CCA>ACA	p.P608T		NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	608										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					CGAGTCCCTGGAAGCAATCTG	0.333		NaN											1	0	8.12818e-05	0.001984	9.68923e-05	7	36									
QSER1	79832	broad.mit.edu	37	11	32955538	32955538	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:32955538C>T	uc001mty.2	+	4	2614	c.2347C>T	c.(2347-2349)CAG>TAG	p.Q783*	QSER1_uc001mtz.1_Nonsense_Mutation_p.Q544*|QSER1_uc001mua.2_Nonsense_Mutation_p.Q288*	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	783	Gln-rich.							p.Q783Q(1)		ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					TGATCATTCTCAGCAGCAACT	0.403		NaN											0	0	0	0.004007	0	16	104									
CSTF3	1479	broad.mit.edu	37	11	33108639	33108639	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:33108639C>A	uc001muh.2	-	18	1856	c.1690G>T	c.(1690-1692)GCT>TCT	p.A564S	TCP11L1_uc001muf.1_Intron	NM_001326	NP_001317	Q12996	CSTF3_HUMAN	cleavage stimulation factor subunit 3 isoform 1	564	Pro-rich.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding				0						ATAGAAGGAGCTACAACTGGG	0.433		NaN											1	0	1.5842e-08	0.001855	1.93326e-08	11	337									
CRY2	1408	broad.mit.edu	37	11	45891150	45891150	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:45891150G>C	uc010rgn.1	+	7	1061	c.1039G>C	c.(1039-1041)GAC>CAC	p.D347H	CRY2_uc009ykw.2_Missense_Mutation_p.D265H|CRY2_uc010rgo.1_Missense_Mutation_p.D69H	NM_021117	NP_066940	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like) isoform 1	326	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			central_nervous_system(1)	1						CCCCAGGTTTGACCGCATGGA	0.592		NaN											0	0	0	0.007835	0	42	100									
DGKZ	8525	broad.mit.edu	37	11	46387826	46387826	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:46387826G>A	uc001ncn.1	+	2	145	c.20G>A	c.(19-21)AGA>AAA	p.R7K	DGKZ_uc001nch.1_Intron|DGKZ_uc010rgq.1_Intron|DGKZ_uc001ncj.1_Intron|DGKZ_uc010rgr.1_Intron|DGKZ_uc001nck.1_Intron|DGKZ_uc001ncl.2_Intron|DGKZ_uc001ncm.2_Intron|DGKZ_uc009yky.1_Intron|DGKZ_uc010rgs.1_Intron|DGKZ_uc001nci.1_Intron	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	7					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TTCTTTAGGAGACATTTCCGG	0.682		NaN											0	0	0	0.001984	0	7	19									
DGKZ	8525	broad.mit.edu	37	11	46397143	46397143	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:46397143G>A	uc001ncn.1	+	21	2561	c.2436G>A	c.(2434-2436)CAG>CAA	p.Q812Q	DGKZ_uc001nch.1_Silent_p.Q640Q|DGKZ_uc010rgq.1_Silent_p.Q567Q|DGKZ_uc001ncj.1_Silent_p.Q590Q|DGKZ_uc010rgr.1_Silent_p.Q589Q|DGKZ_uc001nck.1_Silent_p.Q402Q|DGKZ_uc001ncl.2_Silent_p.Q624Q|DGKZ_uc001ncm.2_Silent_p.Q623Q|DGKZ_uc009yky.1_Silent_p.Q624Q|DGKZ_uc010rgs.1_Silent_p.Q601Q	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	812					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		CCATGGTGCAGAAGGCCAAGC	0.507		NaN											0	0	0	0.004482	0	5	12									
ARFGAP2	84364	broad.mit.edu	37	11	47198344	47198344	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:47198344G>C	uc001ndt.2	-	1	76	c.61C>G	c.(61-63)CCA>GCA	p.P21A	ARFGAP2_uc010rha.1_5'Flank|ARFGAP2_uc010rhb.1_Missense_Mutation_p.P21A|ARFGAP2_uc001ndu.2_Missense_Mutation_p.P21A|ARFGAP2_uc010rhc.1_5'UTR|ARFGAP2_uc010rhd.1_Missense_Mutation_p.P21A|ARFGAP2_uc001ndv.1_Missense_Mutation_p.P21A	NM_032389	NP_115765	Q8N6H7	ARFG2_HUMAN	ADP-ribosylation factor GTPase activating	21	Arf-GAP.				protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			ovary(1)	1						TTGTTGGTTGGAACTGCGCGA	0.617		NaN											0	0	0	0.004482	0	8	44									
DDB2	1643	broad.mit.edu	37	11	47254407	47254407	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:47254407C>T	uc001neb.2	+	4	694	c.499C>T	c.(499-501)CTC>TTC	p.L167F	DDB2_uc001nec.2_RNA|DDB2_uc009yli.1_Missense_Mutation_p.L103F|DDB2_uc001ned.2_Intron|DDB2_uc001nee.2_Intron|DDB2_uc001nef.2_Intron|DDB2_uc001neg.2_Missense_Mutation_p.L31F|DDB2_uc001neh.2_RNA	NM_000107	NP_000098	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2	167	WD 2.				nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			kidney(2)|ovary(1)	3						GTTTAACCCTCTCAATACCAA	0.498		NaN	Mis|N			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.000978	0	10	112									
DDB2	1643	broad.mit.edu	37	11	47254409	47254409	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:47254409C>T	uc001neb.2	+	4	696	c.501C>T	c.(499-501)CTC>CTT	p.L167L	DDB2_uc001nec.2_RNA|DDB2_uc009yli.1_Silent_p.L103L|DDB2_uc001ned.2_Intron|DDB2_uc001nee.2_Intron|DDB2_uc001nef.2_Intron|DDB2_uc001neg.2_Silent_p.L31L|DDB2_uc001neh.2_RNA	NM_000107	NP_000098	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2	167	WD 2.				nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			kidney(2)|ovary(1)	3						TTAACCCTCTCAATACCAACC	0.498		NaN	Mis|N			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.000978	0	10	112									
FNBP4	23360	broad.mit.edu	37	11	47744605	47744605	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:47744605G>C	uc009ylv.2	-	15	2881	c.2728C>G	c.(2728-2730)CCT>GCT	p.P910A	FNBP4_uc001ngi.2_Missense_Mutation_p.P224A|FNBP4_uc001ngj.2_Missense_Mutation_p.P817A	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	910	Pro-rich.									ovary(1)	1						ggaggaggaggaggtggtggt	0.353		NaN											0	0	0	0.001168	0	6	6									
PTPRJ	5795	broad.mit.edu	37	11	48152048	48152048	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:48152048C>T	uc001ngp.3	+	8	1750	c.1395C>T	c.(1393-1395)GTC>GTT	p.V465V	PTPRJ_uc001ngo.3_Silent_p.V465V	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	465	Extracellular (Potential).|Fibronectin type-III 5.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						TGACAGTGGTCAGCACGACGG	0.468		NaN											0	0	0	0.004007	0	16	44									
OR5L2	26338	broad.mit.edu	37	11	55595152	55595152	+	Missense_Mutation	SNP	C	C	T	rs144590289	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:55595152C>T	uc001nhy.1	+	1	458	c.458C>T	c.(457-459)ACG>ATG	p.T153M		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				TTCTGTGGGACGGTGTGTTCT	0.488		NaN								HNSCC(27;0.073)			0	0	0	0.004878	0	35	127									
OR5T3	390154	broad.mit.edu	37	11	56020545	56020545	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:56020545G>A	uc010rjd.1	+	1	870	c.870G>A	c.(868-870)ATG>ATA	p.M290I		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	290	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					TCAGTTATATGAGACCAAGTT	0.403		NaN											0	0	0	0.000978	0	11	96									
OR5T1	390155	broad.mit.edu	37	11	56043552	56043552	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:56043552G>A	uc001nio.1	+	1	438	c.438G>A	c.(436-438)GTG>GTA	p.V146V		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	146	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					TGTATTCAGTGAGCATGTCAC	0.438		NaN											0	0	0	0.00361	0	64	200									
OR8K1	390157	broad.mit.edu	37	11	56114212	56114212	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:56114212G>C	uc010rjg.1	+	1	698	c.698G>C	c.(697-699)AGA>ACA	p.R233T		NM_001002907	NP_001002907	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					GCCATTCTCAGAATGAACTCA	0.378		NaN								HNSCC(65;0.19)			0	0	0	0.001368	0	13	53									
OR5A2	219981	broad.mit.edu	37	11	59190117	59190117	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:59190117C>A	uc010rkt.1	-	1	310	c.310G>T	c.(310-312)GTC>TTC	p.V104F		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCACAGAAGACAAAGTACTGA	0.507		NaN											1	0	2.37509e-13	0.001523	2.96629e-13	21	56									
OR4D11	219986	broad.mit.edu	37	11	59271544	59271544	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:59271544C>T	uc001noa.1	+	1	496	c.496C>T	c.(496-498)CTC>TTC	p.L166F		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GTTGCTGCCTCTCCCTTTCTG	0.517		NaN											0	0	0	0.00361	0	54	172									
OR4D11	219986	broad.mit.edu	37	11	59271963	59271963	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:59271963C>T	uc001noa.1	+	1	915	c.915C>T	c.(913-915)CTC>CTT	p.L305L		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AGAGAAGACTCGTGCCTTCTG	0.308		NaN											0	0	0	0.008291	0	11	53									
FTH1	2495	broad.mit.edu	37	11	61732243	61732243	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:61732243G>C	uc001nsu.2	-	4	743	c.508C>G	c.(508-510)CTC>GTC	p.L170V		NM_002032	NP_002023	P02794	FRIH_HUMAN	ferritin, heavy polypeptide 1	170					cell proliferation|cellular membrane organization|immune response|intracellular sequestering of iron ion|iron ion transport|negative regulation of cell proliferation|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|ferroxidase activity|protein binding			ovary(1)	1					Iron Dextran(DB00893)	TTGTCAAAGAGATATTCCGCC	0.522		NaN											0	0	0	0.003954	0	24	70									
FTH1	2495	broad.mit.edu	37	11	61732561	61732561	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:61732561C>G	uc001nsu.2	-	3	520	c.285G>C	c.(283-285)GAG>GAC	p.E95D		NM_002032	NP_002023	P02794	FRIH_HUMAN	ferritin, heavy polypeptide 1	95	Ferritin-like diiron.				cell proliferation|cellular membrane organization|immune response|intracellular sequestering of iron ion|iron ion transport|negative regulation of cell proliferation|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|ferroxidase activity|protein binding			ovary(1)	1					Iron Dextran(DB00893)	TCAGCCCGCTCTCCCAGTCAT	0.448		NaN											0	0	0	0.002836	0	33	221									
FTH1	2495	broad.mit.edu	37	11	61732918	61732918	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:61732918C>G	uc001nsu.2	-	2	419	c.184G>C	c.(184-186)GAG>CAG	p.E62Q		NM_002032	NP_002023	P02794	FRIH_HUMAN	ferritin, heavy polypeptide 1	62	Ferritin-like diiron.				cell proliferation|cellular membrane organization|immune response|intracellular sequestering of iron ion|iron ion transport|negative regulation of cell proliferation|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|ferroxidase activity|protein binding			ovary(1)	1					Iron Dextran(DB00893)	TCCCTCTCCTCATGAGATTGG	0.443		NaN											0	0	0	0.008361	0	30	212									
AHNAK	79026	broad.mit.edu	37	11	62289440	62289440	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:62289440G>A	uc001ntl.2	-	5	12749	c.12449C>T	c.(12448-12450)TCT>TTT	p.S4150F	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4150					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TTTGGGCAGAGAAACGTCCAC	0.522		NaN											0	0	0	0.00874	0	45	132									
INTS5	80789	broad.mit.edu	37	11	62414702	62414702	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:62414702G>C	uc001nud.2	-	2	2903	c.2850C>G	c.(2848-2850)CTC>CTG	p.L950L	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	950	Helical; (Potential).				snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						CATGCTCCCGGAGAAAACCCC	0.587		NaN											0	0	0	0.00361	0	49	198									
INTS5	80789	broad.mit.edu	37	11	62415293	62415293	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:62415293G>A	uc001nud.2	-	2	2312	c.2259C>T	c.(2257-2259)GTC>GTT	p.V753V	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	753					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						CACGGCCGATGACTCCAGCAT	0.547		NaN											0	0	0	0.006122	0	17	62									
HNRNPUL2	221092	broad.mit.edu	37	11	62494157	62494157	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:62494157C>G	uc001nuw.2	-	1	665	c.472G>C	c.(472-474)GAG>CAG	p.E158Q	HNRNPUL2_uc001nuu.1_RNA|TTC9C_uc001nux.2_5'Flank|TTC9C_uc001nuy.2_5'Flank	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	158	Glu-rich.				cell killing	nucleus	ATP binding|nucleic acid binding				0						CTCCGCTCCTCGGGTTCGTCT	0.701		NaN											0	0	0	0.001368	0	13	26									
NRXN2	9379	broad.mit.edu	37	11	64410027	64410027	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:64410027G>A	uc001oap.2	-	2	760	c.249C>T	c.(247-249)CTC>CTT	p.L83L	NRXN2_uc001oar.2_Intron|NRXN2_uc001oas.2_Intron|NRXN2_uc001oaq.2_Intron	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	83	Extracellular (Potential).				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CGCCGCGGGTGAGGAAGGGCA	0.731		NaN											0	0	0	0.00308	0	7	18									
PYGM	5837	broad.mit.edu	37	11	64520647	64520647	+	Missense_Mutation	SNP	G	G	C	rs142207594		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:64520647G>C	uc001oax.3	-	12	2233	c.1416C>G	c.(1414-1416)TTC>TTG	p.F472L	PYGM_uc001oay.3_Missense_Mutation_p.F384L	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	472					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	CCAGCTCATAGAAGTCTTTGA	0.577		NaN											0	0	0	0.00361	0	62	146									
ATG2A	23130	broad.mit.edu	37	11	64665196	64665196	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:64665196C>T	uc001obx.2	-	36	5129	c.5014G>A	c.(5014-5016)GAG>AAG	p.E1672K	ATG2A_uc001obw.2_Missense_Mutation_p.E437K	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1672							protein binding			ovary(1)|central_nervous_system(1)	2						ATGGGGACCTCAGACGTGAAG	0.647		NaN											0	0	0	0.001368	0	12	48									
ZNHIT2	741	broad.mit.edu	37	11	64884581	64884581	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:64884581C>T	uc001ocw.2	-	1	590	c.545G>A	c.(544-546)GGA>GAA	p.G182E	uc009yqb.1_Missense_Mutation_p.S151F	NM_014205	NP_055020	Q9UHR6	ZNHI2_HUMAN	zinc finger, HIT domain containing 2	182							metal ion binding			breast(1)	1						CGGGACATCTCCAAGAACCCG	0.726		NaN											0	0	0	0.001984	0	5	14									
RELA	5970	broad.mit.edu	37	11	65427190	65427190	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:65427190G>C	uc001ofg.2	-	6	646	c.506C>G	c.(505-507)TCA>TGA	p.S169*	RELA_uc001ofh.2_Nonsense_Mutation_p.S166*|RELA_uc010ron.1_Nonsense_Mutation_p.S180*|RELA_uc009yqr.2_Nonsense_Mutation_p.S116*|RELA_uc001ofe.2_Nonsense_Mutation_p.S169*|RELA_uc001off.2_Nonsense_Mutation_p.S169*|RELA_uc009yqs.1_RNA	NM_021975	NP_068810	Q04206	TF65_HUMAN	v-rel reticuloendotheliosis viral oncogene	169	RHD.				anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			lung(3)|ovary(1)	4						GGGCCTGCCTGATGGGTCCCG	0.587		NaN											0	0	0	0.007291	0	26	74									
BBS1	582	broad.mit.edu	37	11	66278173	66278173	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:66278173G>A	uc001oij.1	+	1	55	c.43G>A	c.(43-45)GAG>AAG	p.E15K	BBS1_uc001oii.1_Intron|BBS1_uc010rpf.1_RNA|BBS1_uc010rpg.1_Missense_Mutation_p.E15K|BBS1_uc001oik.1_5'UTR|BBS1_uc001oil.1_Missense_Mutation_p.E15K	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	15					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						CTGCGGAGCTGAGAGGTGAAG	0.662		NaN							Bardet-Biedl_syndrome				0	0	0	0.008291	0	9	32									
KDM2A	22992	broad.mit.edu	37	11	67022406	67022406	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:67022406G>A	uc001ojw.2	+	21	4233	c.3369G>A	c.(3367-3369)TTG>TTA	p.L1123L	KDM2A_uc001ojx.2_RNA|KDM2A_uc001ojy.2_Silent_p.L817L|KDM2A_uc001ojz.1_3'UTR|KDM2A_uc001oka.2_Silent_p.L247L	NM_012308	NP_036440	Q9Y2K7	KDM2A_HUMAN	F-box and leucine-rich repeat protein 11	1123	LRR 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9						ACGTCACCTTGATCGACCTTC	0.502		NaN											0	0	0	0.001984	0	6	19									
CHKA	1119	broad.mit.edu	37	11	67888317	67888317	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:67888317C>T	uc001onj.2	-	1	542	c.328G>A	c.(328-330)GAG>AAG	p.E110K	CHKA_uc001onk.2_Missense_Mutation_p.E110K	NM_001277	NP_001268	P35790	CHKA_HUMAN	choline kinase alpha isoform a	110					lipid transport|phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|choline kinase activity|drug binding|ethanolamine kinase activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2					Choline(DB00122)	ATGTGGAACTCGTCCTCGCGG	0.577		NaN											0	0	0	0.004007	0	13	47									
PPFIA1	8500	broad.mit.edu	37	11	70189871	70189871	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:70189871G>C	uc001opo.2	+	15	2002	c.1804G>C	c.(1804-1806)GAT>CAT	p.D602H	PPFIA1_uc001opn.1_Missense_Mutation_p.D602H|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	602					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TGACGTGTCTGATGGTGAAGA	0.532		NaN											0	0	0	0.001984	0	7	58									
ARHGEF17	9828	broad.mit.edu	37	11	73078785	73078785	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:73078785G>A	uc001otu.2	+	21	6173	c.6152G>A	c.(6151-6153)CGA>CAA	p.R2051Q		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	2051					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						ACTGTGGGTCGAGACGACAGC	0.632		NaN											0	0	0	0.004007	0	13	82									
UCP3	7352	broad.mit.edu	37	11	73718076	73718076	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:73718076C>T	uc001our.2	-	2	367	c.12G>A	c.(10-12)CTG>CTA	p.L4L	UCP3_uc001ous.2_Silent_p.L4L	NM_003356	NP_003347	P55916	UCP3_HUMAN	uncoupling protein 3 isoform UCP3L	4					mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			pancreas(1)	1	Breast(11;2.08e-05)					CTGAAGGCTTCAGTCCAACCA	0.602		NaN											0	0	0	0.000978	0	9	31									
C2CD3	26005	broad.mit.edu	37	11	73820130	73820130	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:73820130C>A	uc001ouu.2	-	12	2138	c.1911G>T	c.(1909-1911)TGG>TGT	p.W637C		NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	637						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					GGTTGGAATTCCACCAGTGCT	0.433		NaN											1	0	7.07596e-05	0.006122	8.44891e-05	19	47									
C2CD3	26005	broad.mit.edu	37	11	73844510	73844510	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:73844510G>A	uc001ouu.2	-	6	1275	c.1048C>T	c.(1048-1050)CAT>TAT	p.H350Y	C2CD3_uc001ouv.2_Missense_Mutation_p.H350Y	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	350						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					ATAGGAGGATGAACTTGGTCC	0.393		NaN											0	0	0	0.00245	0	13	20									
MAP6	4135	broad.mit.edu	37	11	75298605	75298605	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:75298605C>T	uc001owu.2	-	4	2006	c.1941G>A	c.(1939-1941)CCG>CCA	p.P647P		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	647	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					TTTCATCCTTCGGATGCTCTG	0.512		NaN											0	0	0	0.00361	0	58	129									
C11orf30	56946	broad.mit.edu	37	11	76257029	76257029	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:76257029G>C	uc001oxl.2	+	20	3605	c.3462G>C	c.(3460-3462)TTG>TTC	p.L1154F	C11orf30_uc001oxm.2_Missense_Mutation_p.L1056F|C11orf30_uc010rsb.1_Missense_Mutation_p.L1169F|C11orf30_uc010rsc.1_Missense_Mutation_p.L1155F|C11orf30_uc001oxn.2_Missense_Mutation_p.L1155F|C11orf30_uc010rsd.1_Missense_Mutation_p.L1063F|C11orf30_uc010rse.1_Missense_Mutation_p.L401F|C11orf30_uc001oxp.2_Intron	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	1154					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						AAATGTCTTTGATGGAAGCTC	0.448		NaN											0	0	0	0.00333	0	26	59									
ODZ4	26011	broad.mit.edu	37	11	78369325	78369325	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:78369325C>G	uc001ozl.3	-	34	8551	c.8088G>C	c.(8086-8088)CAG>CAC	p.Q2696H	ODZ4_uc001ozk.3_Missense_Mutation_p.Q921H|ODZ4_uc009yvb.1_Intron	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2696	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GCACGGCTCTCTGCCGGGCCA	0.657		NaN											0	0	0	0.008291	0	10	21									
CCDC81	60494	broad.mit.edu	37	11	86119250	86119250	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:86119250G>A	uc001pbx.1	+	9	1479	c.1051G>A	c.(1051-1053)GAT>AAT	p.D351N	CCDC81_uc001pbw.1_Missense_Mutation_p.D261N|CCDC81_uc010rtq.1_Missense_Mutation_p.D134N|CCDC81_uc001pby.1_Intron	NM_001156474	NP_001149946	Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81 isoform 1	351										skin(1)	1		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				AGAGATAGAAGATGAGAGACT	0.428		NaN											0	0	0	0.000978	0	11	35									
KBTBD3	143879	broad.mit.edu	37	11	105923824	105923824	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:105923824C>G	uc001pja.2	-	4	2232	c.1592G>C	c.(1591-1593)TGG>TCG	p.W531S	KBTBD3_uc001pjb.2_Missense_Mutation_p.W531S|KBTBD3_uc009yxm.2_Missense_Mutation_p.W452S	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	527										ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		TTCGCCTTTCCAAACACAAGT	0.358		NaN											0	0	0	0.000602	0	5	46									
DDX10	1662	broad.mit.edu	37	11	108577549	108577549	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:108577549C>T	uc001pkm.2	+	10	1372	c.1307C>T	c.(1306-1308)CCT>CTT	p.P436L	DDX10_uc001pkl.1_Missense_Mutation_p.P436L	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	436	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		AAGAAAGTACCTGTGAAGGAA	0.373		NaN	T	NUP98	AML*								0	0	0	0.005443	0	27	154									
ZBTB16	7704	broad.mit.edu	37	11	113934854	113934854	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:113934854G>C	uc001pop.2	+	2	1096	c.832G>C	c.(832-834)GAG>CAG	p.E278Q	ZBTB16_uc001poo.1_Missense_Mutation_p.E278Q|ZBTB16_uc001poq.2_Missense_Mutation_p.E278Q	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	278					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		AAGAGGCAAAGAGGGGCCTGG	0.632		NaN											0	0	0	0.004482	0	8	41									
ABCG4	64137	broad.mit.edu	37	11	119027643	119027643	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:119027643G>C	uc001pvs.2	+	9	1323	c.987G>C	c.(985-987)CAG>CAC	p.Q329H	ABCG4_uc009zar.2_Missense_Mutation_p.Q329H	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	329	Cytoplasmic (Potential).				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GGGCTGTGCAGAATGGGCTGT	0.582		NaN											0	0	0	0.00278	0	22	98									
POU2F3	25833	broad.mit.edu	37	11	120169015	120169015	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:120169015C>T	uc001pxc.2	+	4	276	c.174C>T	c.(172-174)CTC>CTT	p.L58L	POU2F3_uc010rzk.1_5'UTR|POU2F3_uc010rzl.1_5'UTR	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor	58					negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		AGCAGACCCTCTCCCATCGGC	0.532		NaN											0	0	0	0.002522	0	43	227									
C11orf63	79864	broad.mit.edu	37	11	122805334	122805334	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:122805334C>T	uc001pym.2	+	5	1482	c.1185C>T	c.(1183-1185)CCC>CCT	p.P395P		NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	395										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		ATAACCCTCCCAGGCAGCAAC	0.463		NaN											0	0	0	0.00308	0	8	32									
ST14	6768	broad.mit.edu	37	11	130059777	130059777	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:130059777C>T	uc001qfw.2	+	5	777	c.584C>T	c.(583-585)TCA>TTA	p.S195L	ST14_uc010sca.1_5'Flank	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	195	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	GTGGTCACCTCAGTGGTGGCT	0.701		NaN											0	0	0	0.008871	0	18	85									
CACNA1C	775	broad.mit.edu	37	12	2690861	2690861	+	Silent	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:2690861C>A	uc009zdu.1	+	14	2314	c.2001C>A	c.(1999-2001)CTC>CTA	p.L667L	CACNA1C_uc009zdv.1_Silent_p.L664L|CACNA1C_uc001qkb.2_Silent_p.L667L|CACNA1C_uc001qkc.2_Silent_p.L667L|CACNA1C_uc001qke.2_Silent_p.L667L|CACNA1C_uc001qkf.2_Silent_p.L667L|CACNA1C_uc001qjz.2_Silent_p.L667L|CACNA1C_uc001qkd.2_Silent_p.L667L|CACNA1C_uc001qkg.2_Silent_p.L667L|CACNA1C_uc009zdw.1_Silent_p.L667L|CACNA1C_uc001qkh.2_Silent_p.L667L|CACNA1C_uc001qkl.2_Silent_p.L667L|CACNA1C_uc001qkn.2_Silent_p.L667L|CACNA1C_uc001qko.2_Silent_p.L667L|CACNA1C_uc001qkp.2_Silent_p.L667L|CACNA1C_uc001qkr.2_Silent_p.L667L|CACNA1C_uc001qku.2_Silent_p.L667L|CACNA1C_uc001qkq.2_Silent_p.L667L|CACNA1C_uc001qks.2_Silent_p.L667L|CACNA1C_uc001qkt.2_Silent_p.L667L|CACNA1C_uc001qka.1_Silent_p.L202L|CACNA1C_uc001qki.1_Silent_p.L403L|CACNA1C_uc001qkj.1_Silent_p.L403L|CACNA1C_uc001qkk.1_Silent_p.L403L|CACNA1C_uc001qkm.1_Silent_p.L403L|CACNA1C_uc001qkw.2_5'Flank	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	667	II.|Helical; Name=S5 of repeat II; (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	tcttctccctcctGGGGATGC	0.423		NaN											1	0	5.50884e-06	0.001368	6.64382e-06	12	86									
ITFG2	55846	broad.mit.edu	37	12	2933049	2933049	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:2933049C>T	uc001qlb.1	+	11	1244	c.1180C>T	c.(1180-1182)CTG>TTG	p.L394L	ITFG2_uc010seb.1_Silent_p.L217L|ITFG2_uc010sec.1_RNA	NM_018463	NP_060933	Q969R8	ITFG2_HUMAN	integrin alpha FG-GAP repeat containing 2	394											0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GTCTACCAATCTGGTGAAACT	0.582		NaN											0	0	0	0.00361	0	43	97									
CD4	920	broad.mit.edu	37	12	6924060	6924060	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:6924060C>T	uc001qqv.1	+	5	754	c.509C>T	c.(508-510)TCC>TTC	p.S170F	CD4_uc009zez.1_Missense_Mutation_p.S115F|CD4_uc009zfa.1_RNA|CD4_uc009zfb.1_RNA|CD4_uc010sfj.1_5'UTR|CD4_uc009zfc.1_5'UTR|CD4_uc010sfk.1_5'UTR|CD4_uc010sfl.1_5'UTR|CD4_uc010sfm.1_5'UTR	NM_000616	NP_000607	P01730	CD4_HUMAN	CD4 antigen precursor	170	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding				0		Myeloproliferative disorder(1001;0.0122)				AAGACCCTCTCCGTGTCTCAG	0.552		NaN											0	0	0	0.001882	0	22	49									
CLEC6A	93978	broad.mit.edu	37	12	8618181	8618181	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:8618181G>A	uc001qum.1	+	4	442	c.325G>A	c.(325-327)GAG>AAG	p.E109K		NM_001007033	NP_001007034	Q6EIG7	CLC6A_HUMAN	dectin-2	109	Extracellular (Potential).|C-type lectin.				defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)	1	Lung SC(5;0.184)					GAACTGTGTTGAGATGGGAGC	0.363		NaN											0	0	0	0.003755	0	30	77									
CLEC12A	160364	broad.mit.edu	37	12	10124258	10124258	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:10124258C>T	uc001qwr.3	+	1	251	c.63C>T	c.(61-63)ATC>ATT	p.I21I	CLEC12A_uc001qwq.2_Silent_p.I31I|CLEC12A_uc001qws.3_Silent_p.I21I|CLEC12A_uc001qwt.2_5'UTR	NM_138337	NP_612210	Q5QGZ9	CL12A_HUMAN	myeloid inhibitory C-type lectin-like receptor	21	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|sugar binding			skin(1)	1						TGGAAAAAATCCCAGAAATTG	0.318		NaN											0	0	0	0.00499	0	18	73									
BCL2L14	79370	broad.mit.edu	37	12	12247765	12247765	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:12247765C>G	uc001rac.2	+	5	1047	c.846C>G	c.(844-846)CTC>CTG	p.L282L	ETV6_uc001raa.1_Intron|BCL2L14_uc001raf.1_Intron|BCL2L14_uc001rad.2_Silent_p.L282L|BCL2L14_uc001rae.2_3'UTR	NM_138723	NP_620049	Q9BZR8	B2L14_HUMAN	BCL2-like 14 isoform 1	282					apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding			skin(1)	1		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)		CGGCCAAGCTCACAGCTATTG	0.552		NaN											0	0	0	0.007291	0	31	91									
PLCZ1	89869	broad.mit.edu	37	12	18876389	18876389	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:18876389C>T	uc010sid.1	-	4	414	c.223G>A	c.(223-225)GAG>AAG	p.E75K	PLCZ1_uc001rdv.3_5'UTR|PLCZ1_uc001rdw.3_Intron	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	75					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					TTGAAAATCTCAATAATTTCT	0.338		NaN											0	0	0	0.004007	0	16	65									
PDE3A	5139	broad.mit.edu	37	12	20801786	20801786	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:20801786G>A	uc001reh.1	+	13	2752	c.2730G>A	c.(2728-2730)CTG>CTA	p.L910L		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	910	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CCACTGACCTGAAGAAACACT	0.323		NaN											0	0	0	0.003271	0	31	64									
C12orf71	728858	broad.mit.edu	37	12	27235150	27235150	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:27235150G>T	uc001rhq.2	-	1	306	c.267C>A	c.(265-267)TTC>TTA	p.F89L		NM_001080406	NP_001073875	A8MTZ7	CL071_HUMAN	hypothetical protein LOC728858	89											0						CCCAGGCCAGGAAGATGCTTA	0.483		NaN											1	0	0.00307968	0.00308	0.00364399	7	52									
IPO8	10526	broad.mit.edu	37	12	30833556	30833556	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:30833556C>T	uc001rjd.2	-	5	669	c.499G>A	c.(499-501)GAG>AAG	p.E167K		NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	167					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GGTTCTCTCTCTTCTGCTTTC	0.318		NaN											0	0	0	0.007413	0	19	136									
KIF21A	55605	broad.mit.edu	37	12	39703448	39703448	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:39703448G>C	uc001rly.2	-	33	4363	c.4217C>G	c.(4216-4218)TCA>TGA	p.S1406*	KIF21A_uc001rlv.2_Nonsense_Mutation_p.S351*|KIF21A_uc001rlw.2_Nonsense_Mutation_p.S676*|KIF21A_uc001rlx.2_Nonsense_Mutation_p.S1393*|KIF21A_uc001rlz.2_Nonsense_Mutation_p.S1353*|KIF21A_uc010skl.1_Nonsense_Mutation_p.S1369*|KIF21A_uc001rlt.2_Nonsense_Mutation_p.S26*|KIF21A_uc001rlu.2_Nonsense_Mutation_p.S26*	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1406	WD 2.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				ATAAGATGTTGATACAGTGAA	0.393		NaN											0	0	0	0.001855	0	12	49									
LRRK2	120892	broad.mit.edu	37	12	40629491	40629491	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:40629491G>A	uc001rmg.3	+	4	532	c.411G>A	c.(409-411)AAG>AAA	p.K137K		NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	137					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTGGACTGAAGACCTTAGATC	0.303		NaN											0	0	0	0.001855	0	12	53									
LASS5	91012	broad.mit.edu	37	12	50536906	50536906	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:50536906G>A	uc001rwd.3	-	3	402	c.385C>T	c.(385-387)CGG>TGG	p.R129W	LASS5_uc001rwc.2_Missense_Mutation_p.R48W|LASS5_uc001rwe.3_Missense_Mutation_p.R70W|LASS5_uc001rwf.3_RNA|LASS5_uc010smq.1_5'UTR	NM_147190	NP_671723	Q8N5B7	CERS5_HUMAN	LAG1 homolog, ceramide synthase 5	129	Cytoplasmic (Potential).|Homeobox.				ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0						TGATTCCTCCGATGGCGAAAC	0.478		NaN											0	0	0	0.00361	0	124	307									
METTL7A	25840	broad.mit.edu	37	12	51323733	51323733	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:51323733G>C	uc001rxb.2	+	2	823	c.535G>C	c.(535-537)GAG>CAG	p.E179Q	METTL7A_uc010smv.1_Nonstop_Mutation_p.*110S	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	methyltransferase like 7A precursor	179						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity				0						TGTGGCAGCTGAGTGTTCGAC	0.428		NaN											0	0	0	0.00361	0	56	188									
METTL7A	25840	broad.mit.edu	37	12	51323817	51323817	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:51323817G>T	uc001rxb.2	+	2	907	c.619G>T	c.(619-621)GAG>TAG	p.E207*	METTL7A_uc010smv.1_3'UTR	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	methyltransferase like 7A precursor	207						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity				0						CCTGACCAGAGAGAGCTGGAA	0.572		NaN											1	0	3.33393e-15	0.004878	4.18558e-15	38	127									
CSRNP2	81566	broad.mit.edu	37	12	51467852	51467852	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:51467852C>T	uc001rxu.1	-	3	463	c.165G>A	c.(163-165)CTG>CTA	p.L55L		NM_030809	NP_110436	Q9H175	CSRN2_HUMAN	TGF-beta induced apoptosis protein 12	55					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						TCTGCCGCTTCAGGATGGATG	0.383		NaN											0	0	0	0.00333	0	25	78									
BIN2	51411	broad.mit.edu	37	12	51686023	51686023	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:51686023C>G	uc001ryg.2	-	10	919	c.867G>C	c.(865-867)GAG>GAC	p.E289D	BIN2_uc009zlz.2_Missense_Mutation_p.E257D|BIN2_uc001ryh.2_Missense_Mutation_p.E165D|BIN2_uc010sng.1_Missense_Mutation_p.E263D	NM_016293	NP_057377	Q9UBW5	BIN2_HUMAN	bridging integrator 2	289						cytoplasm	protein binding			ovary(1)	1						CAGATTCACTCTCACTCTTCA	0.488		NaN											0	0	0	0.004289	0	37	83									
KRT6B	3854	broad.mit.edu	37	12	52843380	52843380	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:52843380G>T	uc001sak.2	-	5	998	c.950C>A	c.(949-951)TCC>TAC	p.S317Y		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	317	Rod.|Linker 12.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		TAGCACCACGGATGTGTCTGA	0.527		NaN											1	0	2.75727e-19	0.004878	3.49206e-19	20	236									
HOXC11	3227	broad.mit.edu	37	12	54367563	54367563	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:54367563G>T	uc001sem.2	+	1	654	c.538G>T	c.(538-540)GAG>TAG	p.E180*		NM_014212	NP_055027	O43248	HXC11_HUMAN	homeobox C11	180					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGCCAAGGGGGAGCCCGAGGC	0.721		NaN	T	NUP98	AML								1	0	0.000157383	0.00308	0.000187454	8	33									
HOXC11	3227	broad.mit.edu	37	12	54367605	54367605	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:54367605G>A	uc001sem.2	+	1	696	c.580G>A	c.(580-582)GAG>AAG	p.E194K		NM_014212	NP_055027	O43248	HXC11_HUMAN	homeobox C11	194					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GTCCCGGGCTGAGGCGGGTGC	0.756		NaN	T	NUP98	AML								0	0	0	0.001984	0	7	13									
HNRNPA1	3178	broad.mit.edu	37	12	54675946	54675946	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:54675946G>C	uc001sfl.2	+	4	456	c.352G>C	c.(352-354)GAA>CAA	p.E118Q	CBX5_uc001sfk.3_5'Flank|CBX5_uc001sfi.3_5'Flank|HNRNPA1_uc001sfm.2_Missense_Mutation_p.E118Q|HNRNPA1_uc009zng.2_Missense_Mutation_p.E118Q|HNRNPA1_uc009znh.2_Missense_Mutation_p.E118Q|HNRNPA1_uc009zni.2_Missense_Mutation_p.E118Q|HNRNPA1_uc001sfn.2_Missense_Mutation_p.E118Q|HNRNPA1_uc001sfo.3_RNA|HNRNPA1_uc001sfp.1_Missense_Mutation_p.E73Q|HNRNPA1_uc009znj.1_Missense_Mutation_p.E73Q	NM_031157	NP_112420	P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	118	Globular B domain.|RRM 2.				interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			skin(2)|ovary(1)	3						AGACACTGAAGAACATCACCT	0.383		NaN											0	0	0	0.00245	0	14	35									
NFE2	4778	broad.mit.edu	37	12	54686808	54686808	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:54686808G>A	uc009znk.2	-	2	982	c.472C>T	c.(472-474)CTT>TTT	p.L158F	NFE2_uc001sfq.2_Missense_Mutation_p.L158F|NFE2_uc001sfr.3_Missense_Mutation_p.L158F|NFE2_uc009znl.2_Missense_Mutation_p.L158F	NM_006163	NP_006154	Q16621	NFE2_HUMAN	nuclear factor, erythroid derived 2 isoform 1	158	Transactivation domain.				blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding				0						TCCAGCTCAAGAGATTCAGCA	0.572		NaN											0	0	0	0.00361	0	48	133									
NFE2	4778	broad.mit.edu	37	12	54686810	54686810	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:54686810G>A	uc009znk.2	-	2	980	c.470C>T	c.(469-471)TCT>TTT	p.S157F	NFE2_uc001sfq.2_Missense_Mutation_p.S157F|NFE2_uc001sfr.3_Missense_Mutation_p.S157F|NFE2_uc009znl.2_Missense_Mutation_p.S157F	NM_006163	NP_006154	Q16621	NFE2_HUMAN	nuclear factor, erythroid derived 2 isoform 1	157	Transactivation domain.				blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding				0						CAGCTCAAGAGATTCAGCATC	0.567		NaN											0	0	0	0.00361	0	50	133									
GPR84	53831	broad.mit.edu	37	12	54756605	54756605	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:54756605C>G	uc001sfu.2	-	2	1121	c.1031G>C	c.(1030-1032)AGA>ACA	p.R344T		NM_020370	NP_065103	Q9NQS5	GPR84_HUMAN	G protein-coupled receptor 84	344	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)	2						AGCCTGGACTCTGGCATCCAG	0.537		NaN											0	0	0	0.00361	0	66	150									
ERBB3	2065	broad.mit.edu	37	12	56481671	56481671	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:56481671T>C	uc001sjh.2	+	6	899	c.706T>C	c.(706-708)TCA>CCA	p.S236P	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.S177P|ERBB3_uc001sji.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	236	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CGGGGGCTGCTCAGGCCCTCA	0.547		NaN											0	0	0	0.00361	0	49	140									
MYL6	4637	broad.mit.edu	37	12	56553863	56553863	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:56553863C>T	uc001sjw.1	+	4	366	c.280C>T	c.(280-282)CGG>TGG	p.R94W	MYL6_uc001sjv.2_Missense_Mutation_p.R94W|MYL6_uc001sjx.1_Missense_Mutation_p.R94W|MYL6_uc010sqd.1_Missense_Mutation_p.R187W|MYL6_uc001sjz.2_Missense_Mutation_p.R59W|MYL6_uc010sqe.1_Missense_Mutation_p.R59W	NM_021019	NP_066299	P60660	MYL6_HUMAN	myosin, light chain 6, alkali, smooth muscle and	94	EF-hand 2.				axon guidance|muscle filament sliding|skeletal muscle tissue development	cytosol|unconventional myosin complex	actin-dependent ATPase activity|calcium ion binding|motor activity|structural constituent of muscle			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(18;0.0979)			CGAAGGACTTCGGGTGTTTGA	0.512		NaN											0	0	0	0.005443	0	27	63									
TIMELESS	8914	broad.mit.edu	37	12	56822358	56822358	+	Silent	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:56822358C>A	uc001slf.2	-	12	1551	c.1383G>T	c.(1381-1383)GTG>GTT	p.V461V	TIMELESS_uc001slg.2_Silent_p.V460V	NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	461					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						TGCTCTCCCTCACAGCCTCAT	0.562		NaN											1	0	0.00136819	0.001368	0.00162558	12	42									
LEMD3	23592	broad.mit.edu	37	12	65639552	65639552	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:65639552G>A	uc001ssl.1	+	11	2497	c.2491G>A	c.(2491-2493)GAG>AAG	p.E831K	LEMD3_uc009zqo.1_Missense_Mutation_p.E830K	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	831	Interaction with SMAD1, SMAD2, SMAD3 and SMAD5.				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		AAATTCACGTGAGGTAAAGTA	0.313		NaN											0	0	0	0.002096	0	34	60									
MDM1	56890	broad.mit.edu	37	12	68707440	68707440	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:68707440G>C	uc001stz.2	-	10	1729	c.1593C>G	c.(1591-1593)CTC>CTG	p.L531L	MDM1_uc010stc.1_Silent_p.L496L|MDM1_uc009zqv.1_Silent_p.L251L	NM_017440	NP_059136	Q8TC05	MDM1_HUMAN	mouse Mdm1 nuclear protein homolog isoform 1	531						nucleus				ovary(3)|skin(2)	5			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		CTGGAGTAGTGAGATCATGAT	0.408		NaN											0	0	0	0.00278	0	24	158									
TBC1D15	64786	broad.mit.edu	37	12	72316827	72316827	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:72316827C>T	uc001swu.2	+	18	1994	c.1985C>T	c.(1984-1986)TCA>TTA	p.S662L	TBC1D15_uc010stt.1_Missense_Mutation_p.S631L|TBC1D15_uc001swv.2_Missense_Mutation_p.S645L|TBC1D15_uc001sww.2_Missense_Mutation_p.S394L	NM_022771	NP_073608	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15 isoform 1	640							protein binding|Rab GTPase activator activity				0						ACACCAGATTCAGACGTTGGT	0.428		NaN											0	0	0	0.006122	0	19	142									
LRRIQ1	84125	broad.mit.edu	37	12	85466779	85466779	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:85466779C>T	uc001tac.2	+	11	2901	c.2790C>T	c.(2788-2790)GTC>GTT	p.V930V	LRRIQ1_uc001tab.1_Silent_p.V930V	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	930										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TGGCACAAGTCTGGATTCCAA	0.403		NaN											0	0	0	0.00499	0	17	76									
EEA1	8411	broad.mit.edu	37	12	93172980	93172980	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:93172980C>G	uc001tck.2	-	25	3830	c.3565G>C	c.(3565-3567)GAG>CAG	p.E1189Q		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	1189	Glu/Lys-rich.|Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						TTTCTCTTCTCCTGTTCAACA	0.388		NaN											0	0	0	0.002445	0	34	100									
DEPDC4	120863	broad.mit.edu	37	12	100657378	100657378	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:100657378C>G	uc001thi.2	-	2	454	c.451G>C	c.(451-453)GAA>CAA	p.E151Q	DEPDC4_uc001thh.1_RNA|DEPDC4_uc001thj.1_Missense_Mutation_p.E84Q|DEPDC4_uc009ztv.1_Missense_Mutation_p.E151Q|DEPDC4_uc001thk.1_Intron|DEPDC4_uc001thl.1_Intron	NM_152317	NP_689530	Q8N2C3	DEPD4_HUMAN	DEP domain containing 4	151	DEP.				intracellular signal transduction						0						TTGGAATCTTCAAATTCTAAT	0.333		NaN											0	0	0	0.00499	0	18	39									
SLC17A8	246213	broad.mit.edu	37	12	100797851	100797851	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:100797851G>A	uc010svi.1	+	9	1402	c.1089G>A	c.(1087-1089)ATG>ATA	p.M363I	SLC17A8_uc009ztx.2_Missense_Mutation_p.M313I	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	363	Helical; (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						ACATGGTTATGACAATCGTTG	0.428		NaN											0	0	0	0.001523	0	20	65									
ALDH1L2	160428	broad.mit.edu	37	12	105456731	105456731	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:105456731C>G	uc001tlc.2	-	7	983	c.856G>C	c.(856-858)GGT>CGT	p.G286R	ALDH1L2_uc009zuo.2_5'UTR|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	286					10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						TTCTTGGCACCTTTAATTTCC	0.403		NaN											0	0	0	0.008871	0	19	55									
SVOP	55530	broad.mit.edu	37	12	109306319	109306319	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:109306319G>C	uc010sxh.1	-	15	1811	c.1639C>G	c.(1639-1641)CAG>GAG	p.Q547E		NM_018711	NP_061181	Q8N4V2	SVOP_HUMAN	SV2 related protein	547	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity				0						CACTATTCCTGAGAGCCAGAG	0.632		NaN											0	0	0	0.00361	0	67	185									
SVOP	55530	broad.mit.edu	37	12	109309593	109309593	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:109309593C>G	uc010sxh.1	-	14	1578	c.1406G>C	c.(1405-1407)AGA>ACA	p.R469T		NM_018711	NP_061181	Q8N4V2	SVOP_HUMAN	SV2 related protein	469	Helical; (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity				0						AGCACCCACTCTTGCCATGCC	0.592		NaN											0	0	0	0.001168	0	4	11									
ERP29	10961	broad.mit.edu	37	12	112460294	112460294	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:112460294G>C	uc001ttk.1	+	3	742	c.624G>C	c.(622-624)AAG>AAC	p.K208N	ERP29_uc001ttl.1_3'UTR	NM_006817	NP_006808	P30040	ERP29_HUMAN	endoplasmic reticulum protein 29 isoform 1	208					intracellular protein transport|protein folding|protein secretion	endoplasmic reticulum lumen|melanosome	protein disulfide isomerase activity				0						TCATGGGGAAGATCTTAGACC	0.542		NaN											0	0	0	0.00499	0	17	48									
TRAFD1	10906	broad.mit.edu	37	12	112585913	112585913	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:112585913C>T	uc001ttp.2	+	8	1049	c.963C>T	c.(961-963)CTC>CTT	p.L321L	TRAFD1_uc001tto.2_Silent_p.L321L|TRAFD1_uc010syj.1_RNA	NM_006700	NP_006691	O14545	TRAD1_HUMAN	TRAF-type zinc finger domain containing 1	321					negative regulation of innate immune response	intracellular	protein binding|zinc ion binding				0						TACCTTCACTCAATACTGGCA	0.423		NaN											0	0	0	0.003163	0	15	47									
OAS3	4940	broad.mit.edu	37	12	113376424	113376424	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:113376424G>A	uc001tug.2	+	1	176	c.89G>A	c.(88-90)CGG>CAG	p.R30Q	OAS3_uc001tue.2_Missense_Mutation_p.R30Q|OAS3_uc001tuf.2_Missense_Mutation_p.R30Q	NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	30	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						GAGAAGGCGCGGCGCGCTCTG	0.721		NaN											0	0	0	0.001984	0	6	31									
FBXW8	26259	broad.mit.edu	37	12	117402587	117402587	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:117402587G>A	uc001twg.1	+	5	845	c.763G>A	c.(763-765)GAG>AAG	p.E255K	FBXW8_uc001twf.1_Missense_Mutation_p.E189K|FBXW8_uc009zwp.1_RNA	NM_153348	NP_699179	Q8N3Y1	FBXW8_HUMAN	F-box and WD repeat domain containing 8 isoform	255	WD 2.						protein binding			ovary(2)|pancreas(1)	3	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0353)		CGAGGAGGATGAGCCTGGAAT	0.522		NaN											0	0	0	0.008871	0	19	176									
CIT	11113	broad.mit.edu	37	12	120288075	120288075	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:120288075G>A	uc001txi.1	-	5	472	c.419C>T	c.(418-420)TCA>TTA	p.S140L	CIT_uc001txj.1_Missense_Mutation_p.S140L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	140	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CTCAAAAAATGAAACCTAGGG	0.393		NaN											0	0	0	0.00361	0	71	202									
DDX55	57696	broad.mit.edu	37	12	124104529	124104529	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:124104529G>C	uc001ufi.2	+	14	1669	c.1645G>C	c.(1645-1647)GAG>CAG	p.E549Q	DDX55_uc001ufk.2_Missense_Mutation_p.E402Q|DDX55_uc001ufl.2_Missense_Mutation_p.E156Q	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	549	Lys-rich.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		TATTGAAGATGAGGACATGGA	0.348		NaN											0	0	0	0.008871	0	19	73									
ATP6V0A2	23545	broad.mit.edu	37	12	124212437	124212437	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:124212437C>T	uc001ufr.2	+	6	877	c.629C>T	c.(628-630)TCC>TTC	p.S210F	ATP6V0A2_uc001ufq.1_Missense_Mutation_p.S210F	NM_012463	NP_036595	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	210	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		CTGGATGAATCCCTTGAAGAC	0.408		NaN											0	0	0	0.001168	0	6	64									
DNAH10	196385	broad.mit.edu	37	12	124398924	124398924	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:124398924G>A	uc001uft.3	+	60	10072	c.10047G>A	c.(10045-10047)CTG>CTA	p.L3349L		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3349					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGAAGCTGCTGGGGGACTGCC	0.607		NaN											0	0	0	0.003954	0	23	74									
SFRS8	6433	broad.mit.edu	37	12	132198734	132198734	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:132198734G>C	uc001uja.1	+	2	477	c.337G>C	c.(337-339)GAG>CAG	p.E113Q	SFRS8_uc010tbn.1_Missense_Mutation_p.E113Q|SFRS8_uc001ujb.1_5'UTR|SFRS8_uc001uiz.1_Missense_Mutation_p.K2N	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	113					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		GTGTGATGAAGAGAGGTATTT	0.453		NaN											0	0	0	0.000602	0	5	35									
GOLGA3	2802	broad.mit.edu	37	12	133381374	133381374	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:133381374C>T	uc001ukz.1	-	7	2084	c.1525G>A	c.(1525-1527)GAG>AAG	p.E509K	GOLGA3_uc001ula.1_Missense_Mutation_p.E509K|GOLGA3_uc001ulb.2_Missense_Mutation_p.E509K	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	509	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		TACTGCTCCTCGGCCACCTGC	0.607		NaN											0	0	0	0.00632	0	28	66									
PARP4	143	broad.mit.edu	37	13	25008601	25008601	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:25008601C>T	uc001upl.2	-	31	4784	c.4678G>A	c.(4678-4680)GAA>AAA	p.E1560K		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1560					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		CACACTATTTCATCCTCTTCT	0.398		NaN											0	0	0	0.003163	0	16	96									
MTMR6	9107	broad.mit.edu	37	13	25826037	25826037	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:25826037G>A	uc001uqf.3	-	12	1751	c.1432C>T	c.(1432-1434)CAC>TAC	p.H478Y	MTMR6_uc001uqe.1_Missense_Mutation_p.H478Y	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	478	Myotubularin phosphatase.					cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		GTAAATCTGTGAGATTCGGAA	0.323		NaN											0	0	0	0.008361	0	29	204									
CDK8	1024	broad.mit.edu	37	13	26928010	26928010	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:26928010G>C	uc001uqr.1	+	4	475	c.449G>C	c.(448-450)AGA>ACA	p.R150T	CDK8_uc001uqs.1_Missense_Mutation_p.R150T|CDK8_uc001uqt.1_5'UTR	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	150	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		GTGTTGCACAGAGATTTGGTA	0.408		NaN											0	0	0	0.004482	0	7	44									
USPL1	10208	broad.mit.edu	37	13	31232711	31232711	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:31232711C>T	uc001utc.2	+	9	2929	c.2497C>T	c.(2497-2499)CCA>TCA	p.P833S	USPL1_uc001utd.2_Missense_Mutation_p.P504S|USPL1_uc001ute.1_Missense_Mutation_p.P504S	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	833					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		AGCAGGCCCTCCATCGTCTAA	0.502		NaN											0	0	0	0.00499	0	14	97									
FRY	10129	broad.mit.edu	37	13	32811517	32811517	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:32811517T>G	uc001utx.2	+	44	6308	c.5812T>G	c.(5812-5814)TCT>GCT	p.S1938A	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1938					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TATACCCAGCTCTTCCTCACC	0.453		NaN											0	0	0	0.008291	0	10	42									
AKAP11	11215	broad.mit.edu	37	13	42874796	42874796	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:42874796A>G	uc001uys.1	+	8	2089	c.1914A>G	c.(1912-1914)ATA>ATG	p.I638M		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	638					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		AGAAGCAGATATTCACAAACA	0.398		NaN											0	0	0	0.00308	0	8	72									
PCDH8	5100	broad.mit.edu	37	13	53421533	53421533	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:53421533C>T	uc001vhi.2	-	1	1242	c.1039G>A	c.(1039-1041)GTC>ATC	p.V347I	PCDH8_uc001vhj.2_Missense_Mutation_p.V347I	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	347	Extracellular (Potential).|Cadherin 3.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TTGTCATTGACGTCTCGGATG	0.726		NaN											0	0	0	0.006214	0	8	31									
PCDH9	5101	broad.mit.edu	37	13	67802023	67802023	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:67802023C>A	uc001vik.2	-	2	1242	c.550G>T	c.(550-552)GGG>TGG	p.G184W	PCDH9_uc001vil.2_Missense_Mutation_p.G184W|PCDH9_uc010thl.1_Missense_Mutation_p.G184W|PCDH9_uc001vin.3_Missense_Mutation_p.G184W	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	184	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		ACACTCTGCCCATTTAACAAT	0.428		NaN											1	0	0.00198382	0.001984	0.00235119	7	141									
ITGBL1	9358	broad.mit.edu	37	13	102235651	102235651	+	Nonsense_Mutation	SNP	T	T	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:102235651T>A	uc001vpb.2	+	6	1032	c.813T>A	c.(811-813)TGT>TGA	p.C271*	ITGBL1_uc010agb.2_Nonsense_Mutation_p.C222*|ITGBL1_uc001vpc.3_Nonsense_Mutation_p.C130*	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	271	V.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CCTGTGAATGTGATGAGAGGG	0.443		NaN											0	0	0	0.002445	0	33	141									
MYO16	23026	broad.mit.edu	37	13	109613989	109613989	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:109613989C>T	uc001vqt.1	+	18	2200	c.2074C>T	c.(2074-2076)CAG>TAG	p.Q692*	MYO16_uc010agk.1_Nonsense_Mutation_p.Q714*|MYO16_uc001vqu.1_Nonsense_Mutation_p.Q492*|MYO16_uc010tjh.1_Nonsense_Mutation_p.Q204*	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	692	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TTCTGACCTCCAGCTCCTGGA	0.458		NaN											0	0	0	0.002222	0	40	68									
MCF2L	23263	broad.mit.edu	37	13	113720402	113720402	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:113720402G>C	uc001vsu.2	+	8	992	c.970G>C	c.(970-972)GAG>CAG	p.E324Q	MCF2L_uc001vsq.2_Missense_Mutation_p.E324Q|MCF2L_uc010tjr.1_Missense_Mutation_p.E267Q|MCF2L_uc001vsr.2_Missense_Mutation_p.E271Q|MCF2L_uc001vss.3_Missense_Mutation_p.E265Q|MCF2L_uc010tjs.1_Missense_Mutation_p.E265Q|MCF2L_uc001vst.1_Missense_Mutation_p.E229Q	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	297					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CAGTGTCCTGGAGAGCCTCAG	0.642		NaN											0	0	0	0.006214	0	9	19									
ATP4B	496	broad.mit.edu	37	13	114309237	114309237	+	Missense_Mutation	SNP	C	C	T	rs142885298	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:114309237C>T	uc001vtz.2	-	2	175	c.133G>A	c.(133-135)GTG>ATG	p.V45M	ATP4B_uc010agy.1_Missense_Mutation_p.V45M	NM_000705	NP_000696	P51164	ATP4B_HUMAN	hydrogen/potassium-exchanging ATPase 4B	45	Helical; Signal-anchor for type II membrane protein; (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	hydrogen:potassium-exchanging ATPase activity|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.00696)|all_epithelial(44;0.00347)|all_lung(25;0.0221)|Breast(118;0.0411)|Lung NSC(25;0.0839)	all cancers(43;0.171)		Rabeprazole(DB01129)	TAGAAGGCCACGTAGTACAGG	0.428		NaN											0	0	0	0.002836	0	34	51									
PABPN1	8106	broad.mit.edu	37	14	23792231	23792231	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:23792231G>A	uc001wjk.2	+	3	1772	c.490G>A	c.(490-492)GAG>AAG	p.E164K	PABPN1_uc001wjh.3_Missense_Mutation_p.E191K|PABPN1_uc001wjj.2_Missense_Mutation_p.E164K	NM_004643	NP_004634	Q86U42	PABP2_HUMAN	poly(A) binding protein, nuclear 1	164	Necessary for homooligomerization.				modification by virus of host mRNA processing|mRNA 3'-end processing|muscle contraction|nuclear mRNA splicing, via spliceosome|poly(A)+ mRNA export from nucleus|termination of RNA polymerase II transcription|viral infectious cycle	cytoplasm|nucleoplasm|ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			ovary(2)	2	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CATGTCCATTGAGGAGAAGAT	0.418		NaN											0	0	0	0.00361	0	62	132									
REC8	9985	broad.mit.edu	37	14	24648862	24648862	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:24648862G>C	uc001wmr.2	+	19	1808	c.1381G>C	c.(1381-1383)GAG>CAG	p.E461Q	REC8_uc001wms.2_Missense_Mutation_p.E461Q	NM_005132	NP_005123	O95072	REC8_HUMAN	REC8 homolog	461	Glu-rich.				mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm					0				GBM - Glioblastoma multiforme(265;0.00839)		TGAACTCCCTGAGGTGCCCAT	0.627		NaN											0	0	0	0.003954	0	27	68									
KHNYN	23351	broad.mit.edu	37	14	24901328	24901328	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:24901328C>G	uc001wph.3	+	3	1063	c.861C>G	c.(859-861)CTC>CTG	p.L287L	KHNYN_uc010tpc.1_Silent_p.L328L|KHNYN_uc010alw.2_Silent_p.L287L|CBLN3_uc001wpg.3_5'Flank	NM_015299	NP_056114	O15037	KHNYN_HUMAN	hypothetical protein LOC23351	287										ovary(2)|liver(1)	3						AAGTGGCCCTCAGGCCACAGT	0.627		NaN									OREG0022627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	8	46									
RALGAPA1	253959	broad.mit.edu	37	14	36096603	36096603	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:36096603C>G	uc001wti.2	-	33	5423	c.5032G>C	c.(5032-5034)GAA>CAA	p.E1678Q	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.E1678Q|RALGAPA1_uc010tpv.1_Missense_Mutation_p.E1691Q|RALGAPA1_uc010tpw.1_Missense_Mutation_p.E1725Q	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1678	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						AGAACATCTTCTTCATCTCTT	0.368		NaN											0	0	0	0.000978	0	11	121									
MGAT2	4247	broad.mit.edu	37	14	50088560	50088560	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:50088560G>A	uc001wwr.2	+	1	1072	c.574G>A	c.(574-576)GAC>AAC	p.D192N	SDCCAG1_uc010anj.1_Intron|RPL36AL_uc001wwq.1_5'Flank	NM_002408	NP_002399	Q10469	MGAT2_HUMAN	mannosyl (alpha-1,6-)-glycoprotein	192	Lumenal (Potential).				oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity				0	all_epithelial(31;0.0021)|Breast(41;0.0124)					TCCAGGTAGTGACCCTAGAGA	0.507		NaN											0	0	0	0.002222	0	45	121									
KLHDC1	122773	broad.mit.edu	37	14	50175883	50175883	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:50175883G>T	uc001www.2	+	2	131	c.103G>T	c.(103-105)GAA>TAA	p.E35*	SDCCAG1_uc010anj.1_Intron|KLHDC1_uc010tqg.1_5'UTR|KLHDC1_uc010tqh.1_5'UTR	NM_172193	NP_751943	Q8N7A1	KLDC1_HUMAN	kelch domain containing 1	35	Kelch 1.					cytoplasm				pancreas(1)	1	all_epithelial(31;0.00244)|Breast(41;0.00964)					TTAGTCTATTGAAGACAATGA	0.289		NaN											1	0	9.31168e-06	0.001855	1.12208e-05	13	74									
GNPNAT1	64841	broad.mit.edu	37	14	53248520	53248520	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:53248520G>A	uc001xab.2	-	4	582	c.327C>T	c.(325-327)TTC>TTT	p.F109F		NM_198066	NP_932332	Q96EK6	GNA1_HUMAN	glucosamine-phosphate N-acetyltransferase 1	109	Substrate binding.|N-acetyltransferase.				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|endosome membrane|Golgi membrane	glucosamine 6-phosphate N-acetyltransferase activity				0	Breast(41;0.176)					AGGAATGGATGAATTTATGTT	0.358		NaN											0	0	0	0.007291	0	30	106									
FBXO34	55030	broad.mit.edu	37	14	55817300	55817300	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:55817300C>G	uc001xbu.2	+	2	437	c.192C>G	c.(190-192)ATC>ATG	p.I64M	FBXO34_uc001xbv.2_5'Flank|FBXO34_uc010aoo.2_Missense_Mutation_p.I64M	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	64										ovary(2)|lung(2)|skin(1)	5						CATTTGGGATCCTTTCTCCAA	0.438		NaN											0	0	0	0.00361	0	54	109									
FBXO34	55030	broad.mit.edu	37	14	55817474	55817474	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:55817474C>G	uc001xbu.2	+	2	611	c.366C>G	c.(364-366)TTC>TTG	p.F122L	FBXO34_uc001xbv.2_5'Flank|FBXO34_uc010aoo.2_Missense_Mutation_p.F122L	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	122										ovary(2)|lung(2)|skin(1)	5						AAATTGCATTCTTTGCATCCC	0.428		NaN											0	0	0	0.002299	0	23	34									
DAAM1	23002	broad.mit.edu	37	14	59819345	59819345	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:59819345G>A	uc001xdz.1	+	19	2417	c.2292G>A	c.(2290-2292)ATG>ATA	p.M764I	DAAM1_uc001xea.1_Missense_Mutation_p.M754I|DAAM1_uc001xec.1_5'Flank	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	764	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		TTTTTGAGATGAGCCGGTGAG	0.398		NaN											0	0	0	0.000248	0	4	14									
DAAM1	23002	broad.mit.edu	37	14	59834201	59834201	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:59834201G>C	uc001xdz.1	+	25	3036	c.2911G>C	c.(2911-2913)GAG>CAG	p.E971Q	DAAM1_uc001xea.1_Missense_Mutation_p.E961Q|DAAM1_uc001xec.1_RNA	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	971	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		ACAACCAGATGAGTTCTTTGG	0.378		NaN											0	0	0	0.003163	0	14	62									
SIX1	6495	broad.mit.edu	37	14	61115580	61115580	+	Missense_Mutation	SNP	G	G	A	rs80356459		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:61115580G>A	uc001xfb.3	-	1	576	c.328C>T	c.(328-330)CGG>TGG	p.R110W		NM_005982	NP_005973	Q15475	SIX1_HUMAN	SIX homeobox 1	110			R -> Q (in BOS3).|R -> W (in BOS3; crucial for EYA1-SIX1 interaction).		branching involved in ureteric bud morphogenesis|embryonic cranial skeleton morphogenesis|epithelial cell differentiation|inner ear morphogenesis|mesonephric tubule formation|metanephric mesenchyme development|myoblast migration|negative regulation of neuron apoptosis|organ induction|pattern specification process|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|protein localization to nucleus|regulation of branch elongation involved in ureteric bud branching|regulation of neuron differentiation|skeletal muscle tissue development|thymus development|thyroid gland development	nucleolus|transcription factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.0201)		CGGCGCACCCGATATTTGCCC	0.632		NaN											0	0	0	0.007835	0	43	76									
GPHN	10243	broad.mit.edu	37	14	67291216	67291216	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:67291216G>A	uc001xiy.2	+	4	1347	c.226G>A	c.(226-228)GAA>AAA	p.E76K	GPHN_uc001xiw.2_Intron|GPHN_uc001xix.2_Missense_Mutation_p.E76K|GPHN_uc010tss.1_Missense_Mutation_p.E76K|GPHN_uc010tst.1_Intron|GPHN_uc010tsu.1_5'UTR	NM_001024218	NP_001019389	Q9NQX3	GEPH_HUMAN	gephyrin isoform 2	76	MPT Mo-transferase.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cell junction|cytoplasm|cytoskeleton|postsynaptic membrane	ATP binding|metal ion binding|nucleotidyltransferase activity			ovary(2)	2		all_cancers(7;0.0476)|all_hematologic(31;0.0116)		Epithelial(1;1.73e-08)|all cancers(60;3.15e-07)|OV - Ovarian serous cystadenocarcinoma(108;0.000275)|BRCA - Breast invasive adenocarcinoma(234;0.00323)|Colorectal(3;0.0938)|KIRC - Kidney renal clear cell carcinoma(182;0.184)		TTGGTGTGATGAAAAGGAACT	0.398		NaN	T	MLL	AL								0	0	0	0.001368	0	11	35									
PCNX	22990	broad.mit.edu	37	14	71479708	71479708	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:71479708C>G	uc001xmo.2	+	11	3231	c.2785C>G	c.(2785-2787)CTC>GTC	p.L929V	PCNX_uc010are.1_Intron|PCNX_uc010arf.1_5'Flank	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	929						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TTAGCTCTCTCTCCCACAGAT	0.328		NaN											0	0	0	0.006214	0	9	62									
DCAF4	26094	broad.mit.edu	37	14	73404761	73404761	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:73404761C>G	uc001xng.2	+	2	295	c.75C>G	c.(73-75)CTC>CTG	p.L25L	DCAF4_uc001xnj.2_Silent_p.L25L|DCAF4_uc010ttr.1_Missense_Mutation_p.S14C|DCAF4_uc001xnh.2_Intron|DCAF4_uc010tts.1_Silent_p.L25L|DCAF4_uc010ttt.1_5'UTR|DCAF4_uc001xni.2_Silent_p.L25L|DCAF4_uc001xnk.2_Silent_p.L25L	NM_015604	NP_056419	Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4 isoform 1	25						CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GGTTCAGACTCCGTGATTCTG	0.488		NaN											0	0	0	0.004878	0	35	102									
RBM25	58517	broad.mit.edu	37	14	73576063	73576063	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:73576063C>T	uc001xno.2	+	14	1763	c.1555C>T	c.(1555-1557)CAG>TAG	p.Q519*	RBM25_uc010ttu.1_Nonsense_Mutation_p.Q519*|RBM25_uc001xnp.2_Nonsense_Mutation_p.Q314*	NM_021239	NP_067062	P49756	RBM25_HUMAN	RNA binding motif protein 25	519	Necessary for nuclear speckle localization.|Glu-rich.|Arg-rich.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		AAGTGCTCTTCAGAAAAGGTT	0.428		NaN											0	0	0	0.00874	0	37	118									
FAM161B	145483	broad.mit.edu	37	14	74411204	74411204	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:74411204G>C	uc001xpd.1	-	3	865	c.759C>G	c.(757-759)CTC>CTG	p.L253L		NM_152445	NP_689658			hypothetical protein LOC145483											ovary(1)	1						TCAAAGAAGAGAGGAGCAGTT	0.567		NaN											0	0	0	0.004656	0	26	74									
TMED8	283578	broad.mit.edu	37	14	77808143	77808143	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:77808143G>C	uc001xto.1	-	6	949	c.949C>G	c.(949-951)CTC>GTC	p.L317V	TMED8_uc010ast.1_RNA|TMED8_uc001xtn.1_Missense_Mutation_p.L161V	NM_213601	NP_998766	Q6PL24	TMED8_HUMAN	transmembrane emp24 protein transport domain	317	GOLD.				transport	integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		TGGAAGTAGAGAGTCTTGTTG	0.577		NaN											0	0	0	0.002522	0	38	86									
AHSA1	10598	broad.mit.edu	37	14	77934848	77934848	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:77934848G>A	uc001xtw.2	+	8	1001	c.841G>A	c.(841-843)GAG>AAG	p.E281K	AHSA1_uc010tvk.1_Missense_Mutation_p.E281K	NM_012111	NP_036243	O95433	AHSA1_HUMAN	activator of heat shock 90kDa protein ATPase	281					protein folding|response to stress	cytosol|endoplasmic reticulum	ATPase activator activity|chaperone binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		ATCTTGGCCAGAGGGTAAGTA	0.279		NaN											0	0	0	0.008871	0	18	61									
EML5	161436	broad.mit.edu	37	14	89124543	89124543	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:89124543C>T	uc001xxg.2	-	27	4051	c.3865G>A	c.(3865-3867)GAA>AAA	p.E1289K	EML5_uc001xxf.2_Missense_Mutation_p.E84K|EML5_uc001xxh.1_Missense_Mutation_p.E428K	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1289						cytoplasm|microtubule				ovary(3)	3						CCATCTTCTTCAGAATCAATG	0.363		NaN											0	0	0	0.005443	0	27	77									
DDX24	57062	broad.mit.edu	37	14	94528596	94528596	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:94528596C>G	uc001ycj.2	-	3	1189	c.1090G>C	c.(1090-1092)GAG>CAG	p.E364Q	DDX24_uc010twq.1_Missense_Mutation_p.E321Q|DDX24_uc010twr.1_Missense_Mutation_p.E114Q	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	364	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		CCAGTCTGCTCTTTATCAAGA	0.483		NaN											0	0	0	0.002852	0	41	110									
DYNC1H1	1778	broad.mit.edu	37	14	102493971	102493971	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:102493971G>C	uc001yks.2	+	47	9228	c.9064G>C	c.(9064-9066)GAA>CAA	p.E3022Q		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3022	AAA 4 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TGGTCTCTTTGAAGGAGACGA	0.542		NaN											0	0	0	0.004007	0	17	44									
DYNC1H1	1778	broad.mit.edu	37	14	102502930	102502930	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:102502930G>A	uc001yks.2	+	57	11023	c.10859G>A	c.(10858-10860)AGA>AAA	p.R3620K		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3620	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						GACGCCTTCAGAAAGAACTTA	0.468		NaN											0	0	0	0.007835	0	40	118									
OR4M2	390538	broad.mit.edu	37	15	22369079	22369079	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:22369079C>T	uc010tzu.1	+	1	504	c.504C>T	c.(502-504)TTC>TTT	p.F168F	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GACTTCCTTTCTGTGGGCCCA	0.493		NaN											0	0	0	0.00361	0	68	406									
MKRN3	7681	broad.mit.edu	37	15	23811021	23811021	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:23811021A>G	uc001ywh.3	+	1	568	c.92A>G	c.(91-93)GAC>GGC	p.D31G	MKRN3_uc001ywi.2_Missense_Mutation_p.D31G|MKRN3_uc010ayi.1_Missense_Mutation_p.D31G	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	31						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TCTGGGCCGGACCTTCCCGTC	0.667		NaN											0	0	0	0.004672	0	3	40									
OCA2	4948	broad.mit.edu	37	15	28277301	28277301	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:28277301G>T	uc001zbh.3	-	3	346	c.236C>A	c.(235-237)TCT>TAT	p.S79Y	OCA2_uc010ayv.2_Missense_Mutation_p.S79Y	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	79	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GGGCAAAGAAGAGTGAGACCT	0.443		NaN							Oculocutaneous_Albinism				1	0	1.75199e-13	0.007291	2.18998e-13	31	82									
HERC2	8924	broad.mit.edu	37	15	28437183	28437183	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:28437183G>A	uc001zbj.2	-	53	8481	c.8375C>T	c.(8374-8376)TCG>TTG	p.S2792L	HERC2_uc001zbk.1_Missense_Mutation_p.S327L	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2792	DOC.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CACGGAGGACGACACATTCAG	0.587		NaN									OREG0022997	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	53	166									
ARHGAP11A	9824	broad.mit.edu	37	15	32929006	32929006	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:32929006C>T	uc001zgy.1	+	12	2754	c.2032C>T	c.(2032-2034)CAA>TAA	p.Q678*	ARHGAP11A_uc010ubw.1_Nonsense_Mutation_p.Q489*|ARHGAP11A_uc010ubx.1_Nonsense_Mutation_p.Q489*	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	678					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TTCACCCCTTCAAACTCAAAC	0.308		NaN											0	0	0	0.001984	0	7	29									
SCG5	6447	broad.mit.edu	37	15	32988730	32988730	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:32988730C>G	uc001zha.2	+	6	676	c.559C>G	c.(559-561)CTA>GTA	p.L187V	SCG5_uc001zgz.2_Missense_Mutation_p.L186V	NM_001144757	NP_001138229	P05408	7B2_HUMAN	secretogranin V isoform 1	187					intracellular protein transport|neuropeptide signaling pathway|peptide hormone processing|regulation of hormone secretion	extracellular region|stored secretory granule	enzyme inhibitor activity|GTP binding|unfolded protein binding				0		all_lung(180;7.32e-08)		all cancers(64;6.48e-17)|Epithelial(43;1.23e-11)|GBM - Glioblastoma multiforme(186;1.39e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0212)		CAATCCATATCTACAAGGACA	0.373		NaN											0	0	0	0.00245	0	13	26									
FAM98B	283742	broad.mit.edu	37	15	38766480	38766480	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:38766480G>C	uc001zkb.1	+	6	745	c.710G>C	c.(709-711)GGA>GCA	p.G237A	FAM98B_uc001zkc.2_Missense_Mutation_p.G237A	NM_001042429	NP_001035894	Q52LJ0	FA98B_HUMAN	family with sequence similarity 98, member B	237						tRNA-splicing ligase complex	protein binding			ovary(1)	1		all_cancers(109;3.11e-17)|all_epithelial(112;2.64e-15)|Lung NSC(122;2.11e-11)|all_lung(180;5.61e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;9e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0209)		CAGTCCTTTGGATGGTCTGAT	0.428		NaN											0	0	0	0.007413	0	18	188									
C15orf23	90417	broad.mit.edu	37	15	40675092	40675092	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:40675092C>T	uc001zll.2	+	1	171	c.56C>T	c.(55-57)TCT>TTT	p.S19F	C15orf23_uc010ucp.1_Missense_Mutation_p.S19F|C15orf23_uc001zlo.2_Missense_Mutation_p.S19F|C15orf23_uc001zlm.2_RNA|C15orf23_uc001zln.2_RNA	NM_033286	NP_150628	Q9Y448	T4AF1_HUMAN	TRAF4 associated factor 1 isoform a	19						nucleus	protein binding			ovary(1)|skin(1)	2		all_cancers(109;2.34e-14)|all_epithelial(112;9.21e-12)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.39e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0798)		ACATGGCTGTCTACAGAGTGC	0.592		NaN											0	0	0	0.001168	0	6	44									
NUSAP1	51203	broad.mit.edu	37	15	41648287	41648287	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:41648287G>T	uc001zns.3	+	5	729	c.499G>T	c.(499-501)GAT>TAT	p.D167Y	NUSAP1_uc001znq.3_5'UTR|NUSAP1_uc001znr.3_Missense_Mutation_p.D167Y|NUSAP1_uc010bce.2_Missense_Mutation_p.D167Y|NUSAP1_uc001znt.3_Missense_Mutation_p.D152Y|NUSAP1_uc001znv.3_Missense_Mutation_p.D166Y|NUSAP1_uc001znu.3_Missense_Mutation_p.D166Y|NUSAP1_uc010ucw.1_Missense_Mutation_p.D144Y|NUSAP1_uc001znw.3_5'UTR	NM_016359	NP_057443	Q9BXS6	NUSAP_HUMAN	nucleolar and spindle associated protein 1	167					cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding				0		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)		TCTCTACACAGATGAGTCATC	0.358		NaN											1	0	0.00198382	0.001984	0.00235119	5	20									
MGA	23269	broad.mit.edu	37	15	42021428	42021428	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:42021428C>T	uc010ucy.1	+	11	3905	c.3724C>T	c.(3724-3726)CGA>TGA	p.R1242*	MGA_uc010ucz.1_Nonsense_Mutation_p.R1242*	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1242						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity	p.R1242P(1)		ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TGCTCGAGTTCGAGTATATGA	0.413		NaN											0	0	0	0.001368	0	12	46									
MGA	23269	broad.mit.edu	37	15	42028655	42028655	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:42028655C>G	uc010ucy.1	+	13	4374	c.4193C>G	c.(4192-4194)TCT>TGT	p.S1398C	MGA_uc010ucz.1_Missense_Mutation_p.S1398C|MGA_uc010uda.1_Intron	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1398						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GTGAAAATCTCTATGCCATCA	0.468		NaN											0	0	0	0.00499	0	17	56									
MGA	23269	broad.mit.edu	37	15	42028795	42028795	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:42028795C>T	uc010ucy.1	+	13	4514	c.4333C>T	c.(4333-4335)CAT>TAT	p.H1445Y	MGA_uc010ucz.1_Missense_Mutation_p.H1445Y|MGA_uc010uda.1_Intron	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1445						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GGAGAGATTACATGGAGGCAA	0.493		NaN											0	0	0	0.001855	0	13	47									
MGA	23269	broad.mit.edu	37	15	42042799	42042799	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:42042799G>C	uc010ucy.1	+	17	7175	c.6994G>C	c.(6994-6996)GAT>CAT	p.D2332H	MGA_uc010ucz.1_Missense_Mutation_p.D2123H|MGA_uc010uda.1_Missense_Mutation_p.D948H|MGA_uc001zoi.2_Missense_Mutation_p.D546H	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2293	Basic motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TGAGGAGGTTGATGATGTAGA	0.348		NaN											0	0	0	0.001168	0	5	19									
MAPKBP1	23005	broad.mit.edu	37	15	42092064	42092064	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:42092064G>T	uc001zok.3	+	3	444	c.158G>T	c.(157-159)AGA>ATA	p.R53I	MAPKBP1_uc001zoj.3_Missense_Mutation_p.R53I|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Missense_Mutation_p.R53I|MAPKBP1_uc010udb.1_Intron|MAPKBP1_uc010bck.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	53										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		TCTGGAGGCAGAGGACTTGCC	0.498		NaN											1	0	4.79706e-38	0.00361	6.14024e-38	61	169									
MAPKBP1	23005	broad.mit.edu	37	15	42092078	42092078	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:42092078G>A	uc001zok.3	+	3	458	c.172G>A	c.(172-174)GAC>AAC	p.D58N	MAPKBP1_uc001zoj.3_Missense_Mutation_p.D58N|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Missense_Mutation_p.D58N|MAPKBP1_uc010udb.1_Intron|MAPKBP1_uc010bck.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	58										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		ACTTGCCTGTGACCCCCGATC	0.502		NaN											0	0	0	0.00361	0	57	162									
GANC	2595	broad.mit.edu	37	15	42584941	42584941	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:42584941C>T	uc001zpi.2	+	5	652	c.338C>T	c.(337-339)TCA>TTA	p.S113L	GANC_uc001zph.2_Missense_Mutation_p.S113L|GANC_uc001zpj.1_5'UTR	NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	113					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		AGGCTGATTTCATGCTCTGGG	0.413		NaN											0	0	0	0.005443	0	29	70									
UBR1	197131	broad.mit.edu	37	15	43281096	43281096	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:43281096C>G	uc001zqq.2	-	35	3984	c.3918G>C	c.(3916-3918)TTG>TTC	p.L1306F		NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	1306					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		GTGGCACTTTCAATCCAATTC	0.373		NaN											0	0	0	0.003755	0	38	105									
SQRDL	58472	broad.mit.edu	37	15	45965961	45965961	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:45965961C>T	uc001zvt.2	+	6	805	c.616C>T	c.(616-618)CAG>TAG	p.Q206*	SQRDL_uc001zvu.2_Nonsense_Mutation_p.Q206*|SQRDL_uc001zvv.2_Nonsense_Mutation_p.Q206*	NM_021199	NP_067022	Q9Y6N5	SQRD_HUMAN	sulfide dehydrogenase like precursor	206							oxidoreductase activity			ovary(1)	1		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		TGGAGCCCCTCAGAAGATCAT	0.478		NaN											0	0	0	0.003163	0	15	64									
DMXL2	23312	broad.mit.edu	37	15	51772908	51772908	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:51772908C>G	uc002abf.2	-	24	6620	c.6395G>C	c.(6394-6396)AGA>ACA	p.R2132T	DMXL2_uc002abd.2_Missense_Mutation_p.R202T|DMXL2_uc010ufy.1_Missense_Mutation_p.R2132T|DMXL2_uc010bfa.2_Missense_Mutation_p.R1496T	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2132	Potential.					cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		CTGCAATCTTCTTCTTTCTAT	0.423		NaN											0	0	0	0.002836	0	33	136									
DMXL2	23312	broad.mit.edu	37	15	51772963	51772963	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:51772963C>T	uc002abf.2	-	24	6565	c.6340G>A	c.(6340-6342)GAA>AAA	p.E2114K	DMXL2_uc002abd.2_Missense_Mutation_p.E184K|DMXL2_uc010ufy.1_Missense_Mutation_p.E2114K|DMXL2_uc010bfa.2_Missense_Mutation_p.E1478K	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2114						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TCTACCATTTCTTCCTGATCC	0.398		NaN											0	0	0	0.004656	0	25	130									
DMXL2	23312	broad.mit.edu	37	15	51772972	51772972	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:51772972C>G	uc002abf.2	-	24	6556	c.6331G>C	c.(6331-6333)GAT>CAT	p.D2111H	DMXL2_uc002abd.2_Missense_Mutation_p.D181H|DMXL2_uc010ufy.1_Missense_Mutation_p.D2111H|DMXL2_uc010bfa.2_Missense_Mutation_p.D1475H	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2111						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TCTTCCTGATCCAGCAGATCA	0.393		NaN											0	0	0	0.00333	0	22	125									
DMXL2	23312	broad.mit.edu	37	15	51773374	51773374	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:51773374C>G	uc002abf.2	-	24	6154	c.5929G>C	c.(5929-5931)GAT>CAT	p.D1977H	DMXL2_uc002abd.2_Missense_Mutation_p.D47H|DMXL2_uc010ufy.1_Missense_Mutation_p.D1977H|DMXL2_uc010bfa.2_Missense_Mutation_p.D1341H	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1977						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TCACCCCAATCAAGATTAAGA	0.408		NaN											0	0	0	0.00361	0	72	193									
ONECUT1	3175	broad.mit.edu	37	15	53081206	53081206	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:53081206G>C	uc002aci.1	-	1	1004	c.876C>G	c.(874-876)ATC>ATG	p.I292M		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	292	CUT.				endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)		CTTTGGTATTGATCTCTTCCA	0.627		NaN											0	0	0	0.003755	0	36	101									
ALDH1A2	8854	broad.mit.edu	37	15	58285149	58285149	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:58285149G>A	uc002aex.2	-	6	736	c.678C>T	c.(676-678)ATC>ATT	p.I226I	ALDH1A2_uc002aey.2_Silent_p.I226I|ALDH1A2_uc010ugv.1_Silent_p.I205I|ALDH1A2_uc010ugw.1_Silent_p.I197I|ALDH1A2_uc002aew.2_Silent_p.I130I	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	226					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTACCTCCTTGATGAGGGCTC	0.473		NaN											0	0	0	0.00361	0	48	125									
VPS13C	54832	broad.mit.edu	37	15	62283250	62283250	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:62283250G>T	uc002agz.2	-	18	1601	c.1527C>A	c.(1525-1527)TTC>TTA	p.F509L	VPS13C_uc002aha.2_Missense_Mutation_p.F466L|VPS13C_uc002ahb.1_Missense_Mutation_p.F509L|VPS13C_uc002ahc.1_Missense_Mutation_p.F466L	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	509					protein localization					ovary(2)	2						CAATGGCAGTGAAGAGTTTAT	0.299		NaN											1	0	2.32416e-17	0.002299	2.93836e-17	21	97									
ANKDD1A	348094	broad.mit.edu	37	15	65239700	65239700	+	Missense_Mutation	SNP	C	C	T	rs145708523	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:65239700C>T	uc002aoa.2	+	13	1267	c.1238C>T	c.(1237-1239)TCT>TTT	p.S413F	ANKDD1A_uc002aoc.2_RNA|ANKDD1A_uc010bha.2_Missense_Mutation_p.S290F	NM_182703	NP_874362	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	413	Death.				signal transduction					ovary(1)	1						CAGCTCCGTTCTGTGCTGTGG	0.592		NaN											0	0	0	0.000978	0	9	20									
NOX5	79400	broad.mit.edu	37	15	69325600	69325600	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:69325600G>C	uc002ars.1	+	5	858	c.838G>C	c.(838-840)GAC>CAC	p.D280H	NOX5_uc002arp.1_Missense_Mutation_p.D262H|NOX5_uc002arq.1_Missense_Mutation_p.D234H|NOX5_uc010bid.1_Missense_Mutation_p.D245H|NOX5_uc002arr.1_Missense_Mutation_p.D252H|NOX5_uc010bie.1_Missense_Mutation_p.D80H|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	280	Helical; (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						CCTCAACTTCGACTGCAGCTT	0.647		NaN											0	0	0	0.000978	0	10	40									
LRRC49	54839	broad.mit.edu	37	15	71256227	71256227	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:71256227C>T	uc002asw.2	+	9	1124	c.877C>T	c.(877-879)CAG>TAG	p.Q293*	LRRC49_uc002asu.2_Nonsense_Mutation_p.Q283*|LRRC49_uc002asx.2_Nonsense_Mutation_p.Q249*|LRRC49_uc010ukf.1_Nonsense_Mutation_p.Q298*|LRRC49_uc002asy.2_5'UTR|LRRC49_uc002asz.2_Nonsense_Mutation_p.Q265*	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	293	LRRCT.					cytoplasm|microtubule				ovary(1)	1						CACTGTCCTTCAGAATATGAT	0.463		NaN											0	0	0	0.00361	0	59	140									
ISLR2	57611	broad.mit.edu	37	15	74427127	74427127	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:74427127G>C	uc002axd.2	+	4	2801	c.2032G>C	c.(2032-2034)GAT>CAT	p.D678H	ISLR2_uc002axe.2_Missense_Mutation_p.D678H|ISLR2_uc010bjg.2_Missense_Mutation_p.D678H|ISLR2_uc010bjf.2_Missense_Mutation_p.D678H	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	678	Cytoplasmic (Potential).				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						GGAGGGCCTTGATGAAGACGC	0.667		NaN									OREG0023277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.002299	0	23	52									
CYP1A1	1543	broad.mit.edu	37	15	75014950	75014950	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:75014950C>T	uc002ayp.3	-	2	611	c.489G>A	c.(487-489)GTG>GTA	p.V163V	CYP1A1_uc010bjv.2_RNA|CYP1A1_uc010bjw.2_RNA|CYP1A1_uc010bju.2_Intron|CYP1A1_uc010bjx.2_Intron|CYP1A1_uc002ayq.3_Silent_p.V163V|CYP1A1_uc010bjy.2_Silent_p.V163V|CYP1A1_uc010bjz.1_Intron	NM_000499	NP_000490	P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A,	163					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			ovary(2)|breast(2)|pancreas(1)	5					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	CCTCCTTGCTCACATGCTCTT	0.582		NaN							Endometrial_Cancer_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia				0	0	0	0.002836	0	34	110									
CSPG4	1464	broad.mit.edu	37	15	75977247	75977247	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:75977247C>T	uc002baw.2	-	5	4372	c.4279G>A	c.(4279-4281)GAG>AAG	p.E1427K		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	1427	CSPG 9.|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						ATCAGCTGCTCTTCCACCTAG	0.552		NaN											0	0	0	0.008871	0	18	62									
FANCI	55215	broad.mit.edu	37	15	89835963	89835963	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:89835963G>C	uc010bnp.1	+	21	2127	c.2037G>C	c.(2035-2037)AAG>AAC	p.K679N	FANCI_uc002bnm.1_Missense_Mutation_p.K679N|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.K500N|FANCI_uc002bnq.1_Missense_Mutation_p.K92N	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	679					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					CCTGGTATAAGAATACAGTCA	0.289		NaN						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.00632	0	29	58									
FANCI	55215	broad.mit.edu	37	15	89836185	89836185	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:89836185G>C	uc010bnp.1	+	22	2272	c.2182G>C	c.(2182-2184)GAT>CAT	p.D728H	FANCI_uc002bnm.1_Missense_Mutation_p.D728H|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.D549H|FANCI_uc002bnq.1_Missense_Mutation_p.D141H	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	728					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					TAAATCAGCAGATTTTTCTCA	0.328		NaN						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.007291	0	29	88									
C15orf42	90381	broad.mit.edu	37	15	90168528	90168528	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:90168528G>C	uc002boe.2	+	20	4987	c.4987G>C	c.(4987-4989)GAT>CAT	p.D1663H	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1663					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			ATTTCAAACAGATGGGGTTCC	0.592		NaN											0	0	0	0.006214	0	10	92									
TTLL13	440307	broad.mit.edu	37	15	90799463	90799463	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:90799463C>T	uc002bpd.1	+	6	927	c.639C>T	c.(637-639)TTC>TTT	p.F213F	TTLL13_uc002bpe.1_Intron	NM_001029964	NP_001025135	A6NNM8	TTL13_HUMAN	tubulin tyrosine ligase-like family, member 13	213	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity				0	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			GTGGCATCTTCATTACCCGAA	0.537		NaN											0	0	0	0.001855	0	10	126									
NGRN	51335	broad.mit.edu	37	15	90808999	90808999	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:90808999C>T	uc002bpf.1	+	1	105	c.55C>T	c.(55-57)CGC>TGC	p.R19C	TTLL13_uc002bpe.1_Intron|NGRN_uc002bpg.1_5'UTR	NM_001033088	NP_001028260	Q9NPE2	NGRN_HUMAN	neugrin	19					neuron differentiation	extracellular region|nucleus				large_intestine(2)|ovary(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			CGCCGTCACTCGCTGTGGGTT	0.692		NaN											0	0	0	0.00245	0	12	36									
MAN2A2	4122	broad.mit.edu	37	15	91456191	91456191	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:91456191C>A	uc010bnz.2	+	17	2669	c.2554C>A	c.(2554-2556)CAC>AAC	p.H852N	MAN2A2_uc002bqc.2_Missense_Mutation_p.H852N|MAN2A2_uc010uql.1_Missense_Mutation_p.H514N|MAN2A2_uc010uqm.1_Missense_Mutation_p.H431N|MAN2A2_uc010uqn.1_RNA	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	852					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			TGAGCACATTCACCAGGCGGT	0.567		NaN											1	0	1.10923e-09	0.00278	1.36521e-09	23	65									
LRRK1	79705	broad.mit.edu	37	15	101588736	101588736	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:101588736G>A	uc002bwr.2	+	22	3492	c.3173G>A	c.(3172-3174)AGG>AAG	p.R1058K	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_Intron	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1058					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AGCAGGAACAGGAAAGTCACC	0.448		NaN											0	0	0	0.004656	0	26	108									
LRRK1	79705	broad.mit.edu	37	15	101601442	101601442	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:101601442G>A	uc002bwr.2	+	30	5065	c.4746G>A	c.(4744-4746)ATG>ATA	p.M1582I	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1582					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GCCCTGGGATGAAGGTGAGCT	0.612		NaN											0	0	0	0.00245	0	13	41									
CHSY1	22856	broad.mit.edu	37	15	101718818	101718818	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:101718818C>T	uc002bwt.1	-	4	1667	c.1184G>A	c.(1183-1185)AGA>AAA	p.R395K	CHSY1_uc010usd.1_Missense_Mutation_p.R123K	NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	395	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GTCCATTCCTCTTCGAGGGGG	0.542		NaN											0	0	0	0.004289	0	35	73									
TARSL2	123283	broad.mit.edu	37	15	102255153	102255153	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:102255153C>G	uc002bxm.2	-	4	635	c.580G>C	c.(580-582)GAA>CAA	p.E194Q	TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	194					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ACCGTGCTTTCAGCCAGTTCC	0.403		NaN											0	0	0	0.001368	0	11	62									
STUB1	10273	broad.mit.edu	37	16	731803	731803	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:731803G>C	uc002cit.2	+	4	946	c.535G>C	c.(535-537)GAG>CAG	p.E179Q	STUB1_uc002ciu.2_Missense_Mutation_p.E107Q|STUB1_uc010bqz.2_RNA|STUB1_uc002civ.2_RNA|JMJD8_uc002ciw.1_3'UTR|JMJD8_uc002cix.1_3'UTR|JMJD8_uc002ciy.1_3'UTR	NM_005861	NP_005852	Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1	179					cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity				0		Hepatocellular(780;0.00335)				GGAGCTGGAAGAGTGCCAGCG	0.627		NaN											0	0	0	0.001882	0	21	55									
HN1L	90861	broad.mit.edu	37	16	1741917	1741917	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:1741917G>A	uc002cmg.2	+	3	303	c.267G>A	c.(265-267)GGG>GGA	p.G89G	HN1L_uc010uvi.1_Silent_p.G117G|HN1L_uc010brt.2_RNA|HN1L_uc010bru.2_Intron|HN1L_uc010uvj.1_Intron|HN1L_uc010uvk.1_Silent_p.G76G	NM_144570	NP_653171	Q9H910	HN1L_HUMAN	hematological and neurological expressed 1-like	89						cytoplasm|nucleus				upper_aerodigestive_tract(1)	1						CACCTGGAGGGAAGACCAGCG	0.542		NaN											0	0	0	0.007413	0	16	74									
MAPK8IP3	23162	broad.mit.edu	37	16	1810466	1810466	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:1810466G>C	uc002cmk.2	+	12	1507	c.1387G>C	c.(1387-1389)GAG>CAG	p.E463Q	MAPK8IP3_uc002cml.2_Missense_Mutation_p.E457Q|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.E464Q	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	463	Potential.				vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						GGGCGAGTTGGAGGCTGCTAA	0.537		NaN											0	0	0	0.005524	0	37	89									
PDPK1	5170	broad.mit.edu	37	16	2647748	2647748	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:2647748C>G	uc002cqs.2	+	14	1795	c.1651C>G	c.(1651-1653)CCG>GCG	p.P551A	PDPK1_uc002cqt.2_Missense_Mutation_p.P424A|PDPK1_uc010bsn.2_3'UTR|PDPK1_uc002cqu.2_Missense_Mutation_p.P524A	NM_002613	NP_002604	O15530	PDPK1_HUMAN	3-phosphoinositide dependent protein kinase-1	551					actin cytoskeleton organization|activation of protein kinase B activity|insulin receptor signaling pathway|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|peptidyl-threonine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|synaptic transmission|T cell costimulation|T cell receptor signaling pathway	cytosol|nucleoplasm|plasma membrane	3-phosphoinositide-dependent protein kinase activity|ATP binding			central_nervous_system(2)|ovary(1)	3		Ovarian(90;0.17)			Celecoxib(DB00482)	CCAGAGCCACCCGGACGCCGC	0.662		NaN											0	0	0	0.00245	0	14	35									
THOC6	79228	broad.mit.edu	37	16	3077242	3077242	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:3077242C>T	uc002ctb.2	+	11	1067	c.771C>T	c.(769-771)ATC>ATT	p.I257I	HCFC1R1_uc002csx.1_5'Flank|HCFC1R1_uc002csy.1_5'Flank|HCFC1R1_uc002csz.1_5'Flank|THOC6_uc002ctd.2_Silent_p.I257I|THOC6_uc002ctc.2_Silent_p.I233I|THOC6_uc002cta.2_Silent_p.I233I	NM_024339	NP_077315	Q86W42	THOC6_HUMAN	WD repeat domain 58 isoform 1	257	WD 6.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	RNA binding			ovary(1)|central_nervous_system(1)	2						TCTTCCCCATCCGGGCGCCAC	0.637		NaN											0	0	0	0.004289	0	38	87									
CREBBP	1387	broad.mit.edu	37	16	3777746	3777746	+	Silent	SNP	C	C	T	rs144609433	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:3777746C>T	uc002cvv.2	-	31	7506	c.7302G>A	c.(7300-7302)ACG>ACA	p.T2434T	CREBBP_uc002cvw.2_Silent_p.T2396T	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	2434					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		ACTTCTCTAGCGTGTCCCCCG	0.552		NaN	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.00361	0	66	131									
GSPT1	2935	broad.mit.edu	37	16	11980398	11980398	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:11980398G>A	uc002dbr.2	-	7	796	c.769C>T	c.(769-771)CAC>TAC	p.H257Y	GSPT1_uc002dbu.2_Missense_Mutation_p.H394Y|GSPT1_uc002dbt.2_Missense_Mutation_p.H395Y|GSPT1_uc010bux.2_Missense_Mutation_p.H257Y	NM_001130007	NP_001123479	P15170	ERF3A_HUMAN	G1 to S phase transition 1 isoform 3	257					G1/S transition of mitotic cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation	intracellular	GTP binding|GTPase activity|protein binding|translation release factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GGCATAAAGTGAATGTCCTTT	0.348		NaN											0	0	0	0.002299	0	24	64									
NOMO1	23420	broad.mit.edu	37	16	14951394	14951394	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:14951394G>C	uc002dcv.2	+	11	1168	c.1102G>C	c.(1102-1104)GAG>CAG	p.E368Q		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	368	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						ATTCCGCCTTGAGAACATAAC	0.428		NaN											0	0	0	0.006999	0	29	73									
KIAA0430	9665	broad.mit.edu	37	16	15718772	15718772	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:15718772G>C	uc002ddr.2	-	10	2317	c.2124C>G	c.(2122-2124)CTC>CTG	p.L708L	KIAA0430_uc002ddq.2_Silent_p.L564L|KIAA0430_uc010uzv.1_Silent_p.L704L|KIAA0430_uc010uzw.1_Silent_p.L706L	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	707						peroxisome	nucleotide binding|RNA binding				0						TTCGGGCACTGAGGTTCTCCT	0.408		NaN											0	0	0	0.002445	0	32	66									
SMG1	23049	broad.mit.edu	37	16	18856931	18856931	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:18856931C>G	uc002dfm.2	-	39	6402	c.6039G>C	c.(6037-6039)TTG>TTC	p.L2013F	SMG1_uc010bwb.2_Missense_Mutation_p.L1873F|SMG1_uc010bwa.2_Missense_Mutation_p.L744F|SMG1_uc002dfo.3_Missense_Mutation_p.L311F	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2013					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TGGGCTTCATCAAAGCTGTGT	0.388		NaN											0	0	0	0.003755	0	32	150									
C16orf88	400506	broad.mit.edu	37	16	19726086	19726086	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:19726086C>G	uc002dgq.2	-	2	287	c.272G>C	c.(271-273)AGA>ACA	p.R91T	IQCK_uc002dgr.2_5'Flank|IQCK_uc002dgs.2_5'Flank|IQCK_uc010vat.1_5'Flank|IQCK_uc010bwc.2_5'Flank|IQCK_uc010vau.1_5'Flank	NM_001012991	NP_001013009	Q1ED39	CP088_HUMAN	hypothetical protein LOC400506	91	Lys-rich.					nucleolus					0						CTCTGTCCGTCTAGCAGGCAG	0.473		NaN											0	0	0	0.006122	0	17	92									
DNAH3	55567	broad.mit.edu	37	16	21132097	21132097	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:21132097C>G	uc010vbe.1	-	11	1663	c.1663G>C	c.(1663-1665)GAG>CAG	p.E555Q	DNAH3_uc002die.2_Intron	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	555	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ATGCTGGGCTCTCCTGGCTCA	0.507		NaN											0	0	0	0.004007	0	15	38									
VWA3A	146177	broad.mit.edu	37	16	22157565	22157565	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:22157565G>C	uc010vbq.1	+	27	2835	c.2739G>C	c.(2737-2739)GTG>GTC	p.V913V	VWA3A_uc010bxd.2_RNA|VWA3A_uc002dkg.3_5'UTR|VWA3A_uc010bxe.1_5'UTR	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	913						extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		AGGGAGTGGTGAGACACATCC	0.532		NaN											0	0	0	0.008291	0	10	24									
USP31	57478	broad.mit.edu	37	16	23096215	23096215	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:23096215G>A	uc002dll.2	-	11	1796	c.1796C>T	c.(1795-1797)TCC>TTC	p.S599F	USP31_uc010bxm.2_5'UTR	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	599					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		GAAACACTGGGATAAAGTGCA	0.488		NaN											0	0	0	0.00361	0	114	280									
TNRC6A	27327	broad.mit.edu	37	16	24801938	24801938	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:24801938C>G	uc002dmm.2	+	6	2089	c.1975C>G	c.(1975-1977)CAA>GAA	p.Q659E	TNRC6A_uc010bxs.2_Missense_Mutation_p.Q406E|TNRC6A_uc010vcc.1_Missense_Mutation_p.Q406E|TNRC6A_uc002dmn.2_Missense_Mutation_p.Q406E|TNRC6A_uc002dmo.2_Missense_Mutation_p.Q406E	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	659	Sufficient for interaction with EIF2C2.|Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GACAAATGAGCAAAGCAGTGT	0.468		NaN											0	0	0	0.006122	0	19	52									
TNRC6A	27327	broad.mit.edu	37	16	24802034	24802034	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:24802034C>T	uc002dmm.2	+	6	2185	c.2071C>T	c.(2071-2073)CAG>TAG	p.Q691*	TNRC6A_uc010bxs.2_Nonsense_Mutation_p.Q438*|TNRC6A_uc010vcc.1_Nonsense_Mutation_p.Q438*|TNRC6A_uc002dmn.2_Nonsense_Mutation_p.Q438*|TNRC6A_uc002dmo.2_Nonsense_Mutation_p.Q438*	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	691	Sufficient for interaction with EIF2C2.|Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TGGGGAAAGTCAGAGTAGAGA	0.473		NaN											0	0	0	0.00278	0	23	55									
SULT1A2	6799	broad.mit.edu	37	16	28603594	28603594	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:28603594G>A	uc002dqg.1	-	7	1116	c.765C>T	c.(763-765)TTC>TTT	p.F255F	uc010vct.1_Intron|SULT1A2_uc002dqh.1_Silent_p.F255F	NM_177528	NP_803564	P50226	ST1A2_HUMAN	sulfotransferase family, cytosolic, 1A,	255					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine biosynthetic process|catecholamine metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0						CTTTCCTCATGAAGGGGGAGA	0.602		NaN											0	0	0	0.00361	0	45	152									
SRCAP	10847	broad.mit.edu	37	16	30723652	30723652	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:30723652C>G	uc002dze.1	+	13	2270	c.1885C>G	c.(1885-1887)CTG>GTG	p.L629V	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.L486V|SRCAP_uc010bzz.1_Missense_Mutation_p.L199V	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	629					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GCTAGACTGGCTGGTTACCAT	0.522		NaN											0	0	0	0.001168	0	6	155									
ZNF668	79759	broad.mit.edu	37	16	31075325	31075325	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:31075325G>A	uc010caf.2	-	2	813	c.456C>T	c.(454-456)CTC>CTT	p.L152L	ZNF668_uc002eao.2_Silent_p.L152L|ZNF668_uc010cag.1_Silent_p.L152L	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	152	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						TGAGCTTGGAGAGCGCGCCAT	0.672		NaN											0	0	0	0.001368	0	11	16									
SLC5A2	6524	broad.mit.edu	37	16	31500575	31500575	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:31500575C>G	uc002ecf.3	+	12	1600	c.1581C>G	c.(1579-1581)CTC>CTG	p.L527L	SLC5A2_uc010car.2_RNA|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	527	Helical; (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1						TGCACTACCTCTACTTCGCCA	0.642		NaN											0	0	0	0.001855	0	13	43									
ABCC11	85320	broad.mit.edu	37	16	48237196	48237196	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:48237196G>C	uc002eff.1	-	13	2171	c.1821C>G	c.(1819-1821)CTC>CTG	p.L607L	ABCC11_uc002efg.1_Silent_p.L607L|ABCC11_uc002efh.1_Silent_p.L607L|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	607	ABC transporter 1.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				AGCAGCAGTGGAGCACCTGGA	0.582		NaN							Cerumen_Type				0	0	0	0.006214	0	8	10									
LONP2	83752	broad.mit.edu	37	16	48329968	48329968	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:48329968C>T	uc002efi.1	+	9	1515	c.1426C>T	c.(1426-1428)CTA>TTA	p.L476L	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Silent_p.L432L	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	476					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						AGATCATTATCTAAATGTGGC	0.393		NaN											0	0	0	0.00361	0	61	167									
N4BP1	9683	broad.mit.edu	37	16	48595368	48595368	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:48595368C>G	uc002efp.2	-	2	1423	c.1186G>C	c.(1186-1188)GAA>CAA	p.E396Q		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	396					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				GCTGAAAATTCTCTGTCTTCT	0.348		NaN											0	0	0	0.002299	0	23	47									
CHD9	80205	broad.mit.edu	37	16	53338321	53338321	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:53338321G>C	uc002ehb.2	+	30	6567	c.6403G>C	c.(6403-6405)GAC>CAC	p.D2135H	CHD9_uc002egy.2_Missense_Mutation_p.D2135H|CHD9_uc002ehc.2_Missense_Mutation_p.D2135H|CHD9_uc002ehf.2_Missense_Mutation_p.D1249H|CHD9_uc010cbw.2_Intron|CHD9_uc002ehg.1_Missense_Mutation_p.D141H	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2135	Ser-rich.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				TTCTGATTCTGACTCAGATTC	0.438		NaN											0	0	0	0.001984	0	6	20									
CHD9	80205	broad.mit.edu	37	16	53352139	53352139	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:53352139G>A	uc002ehb.2	+	36	7764	c.7600G>A	c.(7600-7602)GAG>AAG	p.E2534K	CHD9_uc002egy.2_Missense_Mutation_p.E2518K|CHD9_uc002ehc.2_Missense_Mutation_p.E2519K|CHD9_uc002ehf.2_Missense_Mutation_p.E1632K|CHD9_uc010cbw.2_Missense_Mutation_p.E600K	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2534					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				GCAGCTTCATGAGGGAAGACC	0.338		NaN											0	0	0	0.001368	0	12	33									
RBL2	5934	broad.mit.edu	37	16	53498194	53498194	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:53498194C>G	uc002ehi.3	+	12	1735	c.1617C>G	c.(1615-1617)GTC>GTG	p.V539V	RBL2_uc010vgv.1_Silent_p.V465V|RBL2_uc002ehj.2_Silent_p.V249V|RBL2_uc010vgw.1_Silent_p.V323V	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	539	Domain A.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						GCCTTGAGGTCGTCACTTTTT	0.323		NaN											0	0	0	0.004672	0	3	54									
IRX5	10265	broad.mit.edu	37	16	54967645	54967645	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:54967645C>T	uc002ehv.2	+	3	1312	c.1312C>T	c.(1312-1314)CAT>TAT	p.H438Y	IRX5_uc002ehw.2_Missense_Mutation_p.H372Y	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	438					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						TCCGGGGTCTCATTTCAATGG	0.592		NaN											0	0	0	0.008361	0	31	88									
CCDC135	84229	broad.mit.edu	37	16	57732921	57732921	+	Silent	SNP	C	C	T	rs116591936	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:57732921C>T	uc002emi.2	+	3	452	c.363C>T	c.(361-363)AAC>AAT	p.N121N	CCDC135_uc002emj.2_Silent_p.N121N|CCDC135_uc002emk.2_Silent_p.N121N	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	121						cytoplasm				central_nervous_system(1)	1						ACCCCCTGAACGAGTGTGAAG	0.647		NaN											0	0	0	0.001786	0	29	219									
CNGB1	1258	broad.mit.edu	37	16	57957231	57957231	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:57957231G>C	uc002emt.2	-	18	1654	c.1589C>G	c.(1588-1590)CCA>CGA	p.P530R	CNGB1_uc010cdh.2_Missense_Mutation_p.P524R	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	530	Cytoplasmic (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GGACTCTGCTGGTGACAACGC	0.582		NaN											0	0	0	0.001984	0	6	83									
PRSS54	221191	broad.mit.edu	37	16	58319877	58319877	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:58319877C>T	uc002enf.2	-	5	881	c.486G>A	c.(484-486)CAG>CAA	p.Q162Q	PRSS54_uc002eng.2_Silent_p.Q162Q|PRSS54_uc010vie.1_Silent_p.Q63Q	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	162	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CCCAGCAGTTCTGCAAGACTG	0.547		NaN											0	0	0	0.005443	0	28	77									
CNOT1	23019	broad.mit.edu	37	16	58621270	58621270	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:58621270G>C	uc002env.2	-	5	650	c.357C>G	c.(355-357)CTC>CTG	p.L119L	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.L119L|CNOT1_uc002enx.2_Silent_p.L119L|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	119					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TGCTTAATTTGAGCACTTTAC	0.323		NaN											0	0	0	0.006122	0	15	118									
CDH5	1003	broad.mit.edu	37	16	66426236	66426236	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:66426236G>C	uc002eom.3	+	7	1323	c.1167G>C	c.(1165-1167)CTG>CTC	p.L389L	CDH5_uc002eon.1_Silent_p.L389L	NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	389	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		AGAAGCCTCTGATTGGCACAG	0.537		NaN											0	0	0	0.006999	0	41	120									
GFOD2	81577	broad.mit.edu	37	16	67709505	67709505	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:67709505C>T	uc002eub.2	-	3	1006	c.711G>A	c.(709-711)GTG>GTA	p.V237V	GFOD2_uc002eua.1_RNA|GFOD2_uc002euc.2_Silent_p.V132V	NM_030819	NP_110446	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain	237						proteinaceous extracellular matrix	binding|oxidoreductase activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		AGTTGAGTGTCACTGTGCTAC	0.587		NaN											0	0	0	0.001523	0	22	60									
EDC4	23644	broad.mit.edu	37	16	67918030	67918030	+	Silent	SNP	C	C	T	rs142793660	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:67918030C>T	uc002eur.2	+	29	4351	c.4185C>T	c.(4183-4185)CTC>CTT	p.L1395L	EDC4_uc010cer.2_Silent_p.L1014L|EDC4_uc002eus.2_Silent_p.L1125L|EDC4_uc002eut.1_3'UTR|NRN1L_uc002euu.2_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	1395					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		TGCATGGCCTCGTGACCCCCA	0.627		NaN									OREG0023890	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000978	0	11	20									
PLA2G15	23659	broad.mit.edu	37	16	68293167	68293167	+	Silent	SNP	C	C	T	rs142263893		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:68293167C>T	uc002evr.2	+	6	929	c.846C>T	c.(844-846)TTC>TTT	p.F282F	PLA2G15_uc010vld.1_3'UTR|PLA2G15_uc010vle.1_Silent_p.F188F|PLA2G15_uc010vlf.1_Silent_p.F82F|PLA2G15_uc002evs.2_Silent_p.F103F	NM_012320	NP_036452	Q8NCC3	PAG15_HUMAN	lysophospholipase 3 (lysosomal phospholipase A2)	282					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			ovary(1)	1						AGAAGGTGTTCGTGCAGACAC	0.577		NaN											0	0	0	0.001523	0	21	64									
SF3B3	23450	broad.mit.edu	37	16	70589022	70589022	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:70589022G>C	uc002ezf.2	+	13	1834	c.1623G>C	c.(1621-1623)AAG>AAC	p.K541N		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	541					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				CCCCTGGAAAGAAAACAATTG	0.453		NaN											0	0	0	0.003214	0	46	93									
HYDIN	54768	broad.mit.edu	37	16	70843806	70843806	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:70843806C>T	uc002ezr.2	-	85	14888	c.14760G>A	c.(14758-14760)CTG>CTA	p.L4920L	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4921										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GCGTGGCTTTCAGATAGAGCT	0.468		NaN											0	0	0	0.00361	0	196	479									
CHST4	10164	broad.mit.edu	37	16	71571634	71571634	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:71571634G>A	uc002fan.2	+	2	1235	c.1054G>A	c.(1054-1056)GAT>AAT	p.D352N	CHST4_uc002fao.2_Missense_Mutation_p.D352N	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	352	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						AGCCTGTGGCGATGCCATGAA	0.512		NaN									OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	14	77									
PMFBP1	83449	broad.mit.edu	37	16	72156877	72156877	+	Missense_Mutation	SNP	C	C	T	rs145484256		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:72156877C>T	uc002fcc.3	-	19	2891	c.2719G>A	c.(2719-2721)GAG>AAG	p.E907K	PMFBP1_uc002fcd.2_Missense_Mutation_p.E902K|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Missense_Mutation_p.E757K	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	907										ovary(2)	2		Ovarian(137;0.179)				CCTAGTTTCTCATTGGCGACC	0.532		NaN											0	0	0	0.004656	0	25	80									
MLKL	197259	broad.mit.edu	37	16	74706420	74706420	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:74706420G>C	uc002fdb.2	-	11	1839	c.1398C>G	c.(1396-1398)CTC>CTG	p.L466L	MLKL_uc002fdc.2_Silent_p.L258L	NM_152649	NP_689862	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like isoform 1	466	Protein kinase.						ATP binding|protein binding|protein kinase activity			stomach(2)	2						AAAAGGTGGAGAGTTTCTTTA	0.408		NaN											0	0	0	0.00361	0	53	160									
WDR59	79726	broad.mit.edu	37	16	74920244	74920244	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:74920244C>A	uc002fdh.1	-	24	2572	c.2470G>T	c.(2470-2472)GAA>TAA	p.E824*	WDR59_uc002fdf.1_Nonsense_Mutation_p.E269*|WDR59_uc002fdg.1_Nonsense_Mutation_p.E416*	NM_030581	NP_085058	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	824										ovary(1)|breast(1)	2						CGGAGCTCTTCTGGTGAGGAT	0.527		NaN											1	0	6.53348e-20	0.003755	8.28917e-20	35	86									
VAT1L	57687	broad.mit.edu	37	16	77822778	77822778	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:77822778C>G	uc002ffg.1	+	1	296	c.199C>G	c.(199-201)CAG>GAG	p.Q67E		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	67							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						GCCCGAGCCTCAGGACGGCGA	0.672		NaN											0	0	0	0.001984	0	6	13									
PLCG2	5336	broad.mit.edu	37	16	81960752	81960752	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:81960752C>G	uc002fgt.2	+	23	2635	c.2483C>G	c.(2482-2484)TCA>TGA	p.S828*		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	828	SH3.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						GAGGACATCTCAACTGCAGAC	0.527		NaN											0	0	0	0.00361	0	59	144									
MPHOSPH6	10200	broad.mit.edu	37	16	82197748	82197748	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:82197748C>T	uc002fgw.2	-	2	152	c.103G>A	c.(103-105)GAA>AAA	p.E35K		NM_005792	NP_005783	Q99547	MPH6_HUMAN	M-phase phosphoprotein 6	35	Poly-Glu.				M phase of mitotic cell cycle|maturation of 5.8S rRNA	cytoplasm|nucleolus	protein binding|RNA binding				0						ATTTTCTTTTCTTCTTCTTCT	0.353		NaN											0	0	0	0.00278	0	22	58									
KIAA0513	9764	broad.mit.edu	37	16	85120761	85120761	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:85120761A>G	uc002fiu.2	+	12	1395	c.1175A>G	c.(1174-1176)AAC>AGC	p.N392S	KIAA0513_uc010voj.1_Missense_Mutation_p.N382S	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	392						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		GTGATTGGCAACCTGGATGAA	0.602		NaN									OREG0023994	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	14	51									
IL17C	27189	broad.mit.edu	37	16	88706324	88706324	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:88706324C>G	uc002fla.2	+	3	487	c.438C>G	c.(436-438)CTC>CTG	p.L146L		NM_013278	NP_037410	Q9P0M4	IL17C_HUMAN	interleukin 17C precursor	146					cell surface receptor linked signaling pathway|cell-cell signaling|inflammatory response	extracellular space|soluble fraction	cytokine activity				0				BRCA - Breast invasive adenocarcinoma(80;0.0477)		CAGCTGCGCTCAACTCCGTGC	0.687		NaN											0	0	0	0.000978	0	12	25									
IL17C	27189	broad.mit.edu	37	16	88706361	88706361	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:88706361C>T	uc002fla.2	+	3	524	c.475C>T	c.(475-477)CGC>TGC	p.R159C		NM_013278	NP_037410	Q9P0M4	IL17C_HUMAN	interleukin 17C precursor	159					cell surface receptor linked signaling pathway|cell-cell signaling|inflammatory response	extracellular space|soluble fraction	cytokine activity				0				BRCA - Breast invasive adenocarcinoma(80;0.0477)		GCTGGTGCTGCGCCGCCGGCC	0.701		NaN											0	0	0	0.00499	0	17	38									
SPG7	6687	broad.mit.edu	37	16	89611106	89611106	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:89611106G>T	uc002fnj.2	+	10	1396	c.1375G>T	c.(1375-1377)GAC>TAC	p.D459Y	SPG7_uc002fnk.1_RNA	NM_003119	NP_003110	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 isoform 1	459	Mitochondrial matrix (Potential).				cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		GAACCGAGCTGACATTTTGGA	0.602		NaN											1	0	9.39024e-22	0.002222	1.19346e-21	44	87									
SPIRE2	84501	broad.mit.edu	37	16	89929889	89929889	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:89929889C>T	uc002foz.1	+	11	1633	c.1581C>T	c.(1579-1581)TTC>TTT	p.F527F	SPIRE2_uc010ciw.1_Silent_p.F527F|SPIRE2_uc002fpa.1_Silent_p.F479F|SPIRE2_uc010cix.1_Silent_p.F394F	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	527					transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		CCTAGGAGTTCAGCCACCCCG	0.597		NaN											0	0	0	0.001368	0	12	36									
SMG6	23293	broad.mit.edu	37	17	2202598	2202598	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:2202598G>A	uc002fub.1	-	2	1504	c.1449C>T	c.(1447-1449)GTC>GTT	p.V483V	SMG6_uc002fud.1_Silent_p.V452V	NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	483	Interaction with telomeric DNA.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4						ATGTAGGGCTGACTTCATCAT	0.512		NaN											0	0	0	0.00361	0	102	157									
OR1G1	8390	broad.mit.edu	37	17	3030061	3030061	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:3030061G>C	uc002fvc.1	-	1	785	c.785C>G	c.(784-786)TCT>TGT	p.S262C		NM_003555	NP_003546	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGTTGAGGGAGAACTGAAATC	0.483		NaN											0	0	0	0.007413	0	19	35									
CAMKK1	84254	broad.mit.edu	37	17	3779565	3779565	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:3779565G>A	uc002fwt.2	-	10	1042	c.948C>T	c.(946-948)TTC>TTT	p.F316F	CAMKK1_uc002fwu.2_Silent_p.F316F|CAMKK1_uc002fwv.2_Silent_p.F354F	NM_172206	NP_757343	Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase 1	316	Protein kinase.				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		CGGGGGCCATGAATGCTGGGG	0.627		NaN											0	0	0	0.001882	0	21	37									
MYBBP1A	10514	broad.mit.edu	37	17	4451467	4451467	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:4451467G>A	uc002fyb.3	-	12	1757	c.1695C>T	c.(1693-1695)TTC>TTT	p.F565F	MYBBP1A_uc002fxz.3_Silent_p.F565F	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	565	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						GCTGCGCAGTGAAGGGTGTCA	0.662		NaN											0	0	0	0.002299	0	22	34									
EIF4A1	1973	broad.mit.edu	37	17	7480991	7480991	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:7480991G>T	uc002gho.1	+	16	2198	c.873G>T	c.(871-873)AAG>AAT	p.K291N	EIF4A1_uc002ghr.1_Missense_Mutation_p.K291N|EIF4A1_uc002ghq.1_Missense_Mutation_p.K291N|EIF4A1_uc002ghp.1_Missense_Mutation_p.K291N|SNORA67_uc010cml.1_5'Flank|CD68_uc002ghv.2_5'Flank|CD68_uc002ghu.2_5'Flank	NM_001416	NP_001407	P60842	IF4A1_HUMAN	eukaryotic translation initiation factor 4A	291	Helicase C-terminal.				nuclear-transcribed mRNA poly(A) tail shortening	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA cap binding|translation initiation factor activity			ovary(1)	1						TCACCGAGAAGATGCATGCTC	0.547		NaN											1	0	2.98393e-07	0.00278	3.61689e-07	23	107									
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	C	G	rs121912660		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:7577099C>G	uc002gim.2	-	8	1033	c.839G>C	c.(838-840)AGA>ACA	p.R280T	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R280T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R148T|TP53_uc010cng.1_Missense_Mutation_p.R148T|TP53_uc002gii.1_Missense_Mutation_p.R148T|TP53_uc010cnh.1_Missense_Mutation_p.R280T|TP53_uc010cni.1_Missense_Mutation_p.R280T|TP53_uc002gij.2_Missense_Mutation_p.R280T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	280	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> T (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(53)|p.R280K(41)|p.R280G(18)|p.R280S(13)|p.R280I(12)|p.R280*(8)|p.R280fs*65(7)|p.0?(7)|p.R280R(3)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.D281fs*24(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.000978	0	12	20									
CYB5D1	124637	broad.mit.edu	37	17	7761959	7761959	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:7761959G>A	uc002gjb.3	+	3	662	c.273G>A	c.(271-273)CTG>CTA	p.L91L	LSMD1_uc002giz.2_5'Flank|LSMD1_uc002gja.2_5'Flank|CYB5D1_uc010cnn.1_Silent_p.L91L	NM_144607	NP_653208	Q6P9G0	CB5D1_HUMAN	cytochrome b5 domain containing 1	91	Cytochrome b5 heme-binding.						heme binding			skin(1)	1		all_cancers(10;0.11)|Prostate(122;0.219)				CCGGCTGCCTGAGGTACTGCA	0.627		NaN									OREG0024147	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	54	77									
PIK3R5	23533	broad.mit.edu	37	17	8794166	8794166	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:8794166C>G	uc002glt.2	-	7	613	c.546G>C	c.(544-546)CTG>CTC	p.L182L	PIK3R5_uc010vuz.1_Silent_p.L182L|PIK3R5_uc002glu.3_Intron|PIK3R5_uc010coa.1_Silent_p.L182L|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	182					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						CGGGCGTACTCAGCTTATTGG	0.647		NaN											0	0	0	0.004482	0	9	29									
MYH3	4621	broad.mit.edu	37	17	10543550	10543550	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:10543550G>C	uc002gmq.1	-	21	2522	c.2445C>G	c.(2443-2445)ATC>ATG	p.I815M		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	815					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TGTTGTACTGGATGCAGAAGA	0.478		NaN											0	0	0	0.006122	0	18	42									
ZNF624	57547	broad.mit.edu	37	17	16525625	16525625	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:16525625G>C	uc010cpi.1	-	6	2658	c.2575C>G	c.(2575-2577)CAA>GAA	p.Q859E		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	859					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		GTTTCTCTTTGATGTATTCTT	0.323		NaN											0	0	0	0.00278	0	21	69									
CCDC144A	9720	broad.mit.edu	37	17	16612919	16612919	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:16612919G>C	uc002gqk.1	+	5	1624	c.1548G>C	c.(1546-1548)TTG>TTC	p.L516F	CCDC144A_uc002gql.1_Intron|LOC162632_uc010cpj.1_5'Flank	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	516	Potential.										0						TCCTGGCTTTGAAGAAAGAAG	0.353		NaN											0	0	0	0.00361	0	61	104									
SREBF1	6720	broad.mit.edu	37	17	17716007	17716007	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:17716007G>C	uc002gru.1	-	19	3567	c.3373C>G	c.(3373-3375)CGC>GGC	p.R1125G	SREBF1_uc002gro.3_5'Flank|SREBF1_uc002grp.1_Missense_Mutation_p.R744G|SREBF1_uc002grq.1_Missense_Mutation_p.R644G|SREBF1_uc002grr.1_Missense_Mutation_p.R871G|SREBF1_uc002grs.1_Missense_Mutation_p.R1101G|SREBF1_uc002grt.1_Missense_Mutation_p.R1155G	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	1125	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						AGCAGCCGGCGATCGCCAAGC	0.706		NaN											0	0	0	0.004672	0	3	12									
ALDH3A1	218	broad.mit.edu	37	17	19642974	19642974	+	Silent	SNP	G	G	A	rs151020632		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:19642974G>A	uc010cqu.2	-	7	1293	c.963C>T	c.(961-963)CTC>CTT	p.L321L	ALDH3A1_uc010vzd.1_Silent_p.L321L|ALDH3A1_uc002gwj.2_Silent_p.L321L|ALDH3A1_uc010cqv.2_Silent_p.L320L|ALDH3A1_uc002gwk.2_Silent_p.L438L|ALDH3A1_uc002gwl.1_Silent_p.L248L	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	321					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	CCACGTCCGTGAGGATGGTGG	0.642		NaN											0	0	0	0.004007	0	14	47									
TMEM11	8834	broad.mit.edu	37	17	21102080	21102080	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:21102080C>G	uc002gyp.2	-	2	579	c.136G>C	c.(136-138)GAG>CAG	p.E46Q	TMEM11_uc002gyq.2_3'UTR	NM_003876	NP_003867	P17152	TMM11_HUMAN	transmembrane protein 11	46					mitochondrion organization	integral to mitochondrial inner membrane|integral to plasma membrane	protein binding				0						AGCTCGTACTCAAACTGGTCT	0.557		NaN											0	0	0	0.00245	0	14	45									
DHRS13	147015	broad.mit.edu	37	17	27228278	27228278	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:27228278G>A	uc002hde.3	-	4	539	c.412C>T	c.(412-414)CTG>TTG	p.L138L	DHRS13_uc002hdd.3_Silent_p.L88L|DHRS13_uc010wba.1_Silent_p.L57L	NM_144683	NP_653284	Q6UX07	DHR13_HUMAN	dehydrogenase/reductase (SDR family) member 13	138						extracellular region	binding|oxidoreductase activity				0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.59e-06)|all cancers(11;9.27e-06)|BRCA - Breast invasive adenocarcinoma(11;5.78e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			ACCCGAAGCAGCAGGTTAAAC	0.602		NaN											0	0	0	0.000978	0	11	141									
TAOK1	57551	broad.mit.edu	37	17	27861196	27861196	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:27861196G>A	uc002hdz.1	+	19	2616	c.2422G>A	c.(2422-2424)GAA>AAA	p.E808K	TAOK1_uc010wbe.1_Missense_Mutation_p.E660K|TAOK1_uc010wbf.1_Missense_Mutation_p.E808K	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	808	Potential.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			GCTGCAGCAGGAACTGGAGCT	0.488		NaN											0	0	0	0.00361	0	58	43									
EFCAB5	374786	broad.mit.edu	37	17	28380455	28380455	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:28380455G>A	uc002het.2	+	10	1675	c.1483G>A	c.(1483-1485)GAA>AAA	p.E495K	EFCAB5_uc010wbi.1_Missense_Mutation_p.E238K|EFCAB5_uc010wbj.1_Missense_Mutation_p.E439K|EFCAB5_uc010wbk.1_Missense_Mutation_p.E152K|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Missense_Mutation_p.E374K|EFCAB5_uc010csf.2_Missense_Mutation_p.E374K	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	495							calcium ion binding			ovary(1)|skin(1)	2						TAAACTTAACGAACAGAGAAC	0.388		NaN											0	0	0	0.002836	0	33	216									
NF1	4763	broad.mit.edu	37	17	29552264	29552264	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:29552264C>G	uc002hgg.2	+	17	2330	c.1997C>G	c.(1996-1998)TCT>TGT	p.S666C	NF1_uc002hgh.2_Missense_Mutation_p.S666C|NF1_uc010csn.1_Missense_Mutation_p.S526C|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	666					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GGGAACTCCTCTATGGTCAGC	0.373		NaN	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.007413	0	16	111									
RHOT1	55288	broad.mit.edu	37	17	30519316	30519316	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:30519316C>G	uc002hgz.2	+	9	876	c.637C>G	c.(637-639)CAG>GAG	p.Q213E	RHOT1_uc002hgw.2_Missense_Mutation_p.Q213E|RHOT1_uc002hgy.2_Missense_Mutation_p.Q213E|RHOT1_uc002hha.2_Missense_Mutation_p.Q86E|RHOT1_uc010csv.2_RNA|RHOT1_uc002hgx.2_Missense_Mutation_p.Q86E|RHOT1_uc010wby.1_Missense_Mutation_p.Q213E|RHOT1_uc002hhb.2_Missense_Mutation_p.Q192E|RHOT1_uc002hgv.2_Missense_Mutation_p.Q213E	NM_018307	NP_060777	Q8IXI2	MIRO1_HUMAN	ras homolog gene family, member T1 isoform 3	213	EF-hand 1.|Mitochondrial intermembrane (Potential).				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				CAACTTCTTTCAGGTAATGGT	0.303		NaN											0	0	0	0.001368	0	13	59									
PEX12	5193	broad.mit.edu	37	17	33903113	33903113	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:33903113G>C	uc002hjp.2	-	3	1384	c.768C>G	c.(766-768)TTC>TTG	p.F256L		NM_000286	NP_000277	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	256	Helical; (Potential).				protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACTGCAAGAAGAATACACCCA	0.468		NaN											0	0	0	0.007835	0	43	73									
AP2B1	163	broad.mit.edu	37	17	34036247	34036247	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:34036247C>T	uc002hjr.2	+	18	2606	c.2417C>T	c.(2416-2418)GCT>GTT	p.A806V	AP2B1_uc002hjq.2_Missense_Mutation_p.A820V|AP2B1_uc010wci.1_Missense_Mutation_p.A782V|AP2B1_uc002hjs.2_Missense_Mutation_p.A749V|AP2B1_uc002hjt.2_Missense_Mutation_p.A820V|AP2B1_uc010ctv.2_Missense_Mutation_p.A820V|AP2B1_uc010wcj.1_Missense_Mutation_p.A557V	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	806					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		TGGCAGGTGGCTGTGAAAAAC	0.473		NaN											0	0	0	0.000978	0	12	67									
GAS2L2	246176	broad.mit.edu	37	17	34073061	34073061	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:34073061G>A	uc002hjv.1	-	6	1483	c.1455C>T	c.(1453-1455)TTC>TTT	p.F485F		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	485					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTGGCTCCCTGAACTGGAAGA	0.642		NaN											0	0	0	0.00361	0	49	87									
GAS2L2	246176	broad.mit.edu	37	17	34076186	34076186	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:34076186G>C	uc002hjv.1	-	3	706	c.678C>G	c.(676-678)GTC>GTG	p.V226V		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	226	GAR.				cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CAGACACTTTGACCATGGAGA	0.592		NaN											0	0	0	0.000602	0	5	29									
ACACA	31	broad.mit.edu	37	17	35631157	35631157	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:35631157G>C	uc002hnm.2	-	9	1015	c.824C>G	c.(823-825)TCA>TGA	p.S275*	ACACA_uc002hnk.2_Nonsense_Mutation_p.S197*|ACACA_uc002hnl.2_Nonsense_Mutation_p.S217*|ACACA_uc002hnn.2_Nonsense_Mutation_p.S275*|ACACA_uc002hno.2_Nonsense_Mutation_p.S312*|ACACA_uc010cuz.2_Nonsense_Mutation_p.S275*|ACACA_uc002hnq.2_Nonsense_Mutation_p.S197*	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	275	Biotin carboxylation.|ATP-grasp.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GATACGTTTTGAAAAATCATT	0.413		NaN											0	0	0	0.008871	0	17	61									
SRCIN1	80725	broad.mit.edu	37	17	36715882	36715882	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:36715882C>T	uc002hqd.2	-	10	2189	c.1964G>A	c.(1963-1965)CGA>CAA	p.R655Q	SRCIN1_uc002hqf.1_Missense_Mutation_p.R527Q|SRCIN1_uc002hqe.2_Missense_Mutation_p.R509Q|SRCIN1_uc002hqg.2_5'Flank	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	527	Potential.|Interaction with SNAP25 (By similarity).				exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						CTGCAGGCCTCGCAGGTGAAG	0.736		NaN											0	0	0	0.004482	0	8	25									
TOP2A	7153	broad.mit.edu	37	17	38551779	38551779	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:38551779C>T	uc002huq.2	-	29	3859	c.3733G>A	c.(3733-3735)GAA>AAA	p.E1245K		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	1245					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	GGGCTTCCTTCAGTATTTTCA	0.289		NaN											0	0	0	0.004482	0	7	45									
CCR7	1236	broad.mit.edu	37	17	38711414	38711414	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:38711414C>T	uc002huw.2	-	3	780	c.717G>A	c.(715-717)ATG>ATA	p.M239I		NM_001838	NP_001829	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7 precursor	239	Helical; Name=5; (Potential).				cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)	1		Breast(137;0.000496)				AACAGAAGCTCATGGCCAGCA	0.557		NaN											0	0	0	0.008291	0	11	47									
KRT10	3858	broad.mit.edu	37	17	38978738	38978738	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:38978738G>A	uc002hvi.2	-	1	126	c.100C>T	c.(100-102)CTA>TTA	p.L34L	KRT10_uc010cxd.2_5'Flank|TMEM99_uc002hvj.1_Intron	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	34	Head.|Gly-rich.				epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				GAAATTCTTAGGGATGACAct	0.423		NaN											0	0	0	0.00499	0	18	48									
KRT12	3859	broad.mit.edu	37	17	39022938	39022938	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:39022938C>T	uc002hvk.2	-	1	525	c.501G>A	c.(499-501)GGG>GGA	p.G167G		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	167	Rod.|Linker 1.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				CATCTGCAGTCCCAGTTCCTC	0.413		NaN											0	0	0	0.003214	0	46	146									
KRTAP4-7	100132476	broad.mit.edu	37	17	39240819	39240819	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:39240819C>G	uc010wfn.1	+	1	361	c.361C>G	c.(361-363)CTG>GTG	p.L121V		NM_033061	NP_149050			keratin associated protein 4-7												0						ctgctgctgcCTGCGTCCAGT	0.313		NaN											0	0	0	0.000248	0	3	3									
KRT37	8688	broad.mit.edu	37	17	39580734	39580734	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:39580734G>A	uc002hwp.1	-	1	89	c.42C>T	c.(40-42)TGC>TGT	p.C14C	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	14	Head.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				GAGCCATGGTGCAACCCAGAG	0.577		NaN											0	0	0	0.002445	0	30	101									
KRT37	8688	broad.mit.edu	37	17	39580750	39580750	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:39580750G>A	uc002hwp.1	-	1	73	c.26C>T	c.(25-27)TCA>TTA	p.S9L	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	9	Head.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				CAGAGGGCATGAGGAGGTGCT	0.577		NaN											0	0	0	0.002096	0	28	94									
ACLY	47	broad.mit.edu	37	17	40025364	40025364	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:40025364G>C	uc002hyg.2	-	27	3229	c.3066C>G	c.(3064-3066)ATC>ATG	p.I1022M	ACLY_uc002hyh.2_Missense_Mutation_p.I1012M|ACLY_uc002hyi.2_Missense_Mutation_p.I1076M|ACLY_uc010wfx.1_Missense_Mutation_p.I1066M|ACLY_uc010wfy.1_Missense_Mutation_p.I751M	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	1022					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				CTACATTCAGGATAAGATTTG	0.363		NaN											0	0	0	0.00245	0	13	294									
TTC25	83538	broad.mit.edu	37	17	40095357	40095357	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:40095357G>C	uc002hyj.3	+	7	1079	c.990G>C	c.(988-990)CAG>CAC	p.Q330H	TTC25_uc010cxt.2_RNA|TTC25_uc010cxs.1_Intron	NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25	330	TPR 5.					cytoplasm	protein binding	p.Q330Q(1)		ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				GGAATGCCCAGATTGAGCTGG	0.537		NaN											0	0	0	0.004482	0	9	35									
PLEKHH3	79990	broad.mit.edu	37	17	40820225	40820225	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:40820225C>A	uc002iau.2	-	13	2769	c.2302G>T	c.(2302-2304)GAC>TAC	p.D768Y	PLEKHH3_uc010cyl.1_RNA|PLEKHH3_uc002iat.1_RNA|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_Missense_Mutation_p.D129Y|PLEKHH3_uc002iaw.2_3'UTR	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	768					signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		GGGGAGGTGTCTGGCAGGTCT	0.647		NaN											1	0	1.10923e-09	0.00278	1.36521e-09	22	41									
MPP3	4356	broad.mit.edu	37	17	41879119	41879119	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:41879119C>G	uc002iei.3	-	20	1874	c.1708G>C	c.(1708-1710)GAG>CAG	p.E570Q	MPP3_uc002ieh.2_Missense_Mutation_p.E595Q|MPP3_uc002iej.2_RNA	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	570	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		CTCAGCTTCTCTAAGACCACT	0.423		NaN											0	0	0	0.00361	0	46	99									
GFAP	2670	broad.mit.edu	37	17	42987985	42987985	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:42987985C>G	uc002ihq.2	-	7	1229	c.1169G>C	c.(1168-1170)CGA>CCA	p.R390P	GFAP_uc002ihr.2_Missense_Mutation_p.R390P	NM_002055	NP_002046	P14136	GFAP_HUMAN	glial fibrillary acidic protein isoform 1	390	Tail.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			ovary(1)|pancreas(1)	2		Prostate(33;0.0959)				GTACTGACCTCGAATCTGCAG	0.622		NaN											0	0	0	0.000248	0	4	3									
C1QL1	10882	broad.mit.edu	37	17	43037561	43037561	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:43037561C>A	uc002ihv.2	-	2	1000	c.772G>T	c.(772-774)GAC>TAC	p.D258Y		NM_006688	NP_006679	O75973	C1QRF_HUMAN	complement component 1, q subcomponent-like 1	258	C1q.				locomotory behavior	collagen					0		Prostate(33;0.155)				GGAGCTCAGTCGGAGTAGATG	0.657		NaN											1	0	9.39024e-22	0.002222	1.19346e-21	44	122									
MAPT	4137	broad.mit.edu	37	17	44061213	44061213	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:44061213A>T	uc002ijr.3	+	6	1363	c.1043A>T	c.(1042-1044)GAG>GTG	p.E348V	MAPT_uc010dau.2_Missense_Mutation_p.E348V|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	348					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				GACACAAAAGAGGCTGACCTT	0.637		NaN											0	0	0	0.005443	0	27	98									
STH	246744	broad.mit.edu	37	17	44076776	44076776	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:44076776G>C	uc002ijy.2	+	1	161	c.131G>C	c.(130-132)AGA>ACA	p.R44T	MAPT_uc010dau.2_Intron|MAPT_uc002ijr.3_Intron|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_001007532	NP_001007533	Q8IWL8	STH_HUMAN	saitohin	44						cytoplasm|nucleus					0						CAGGTTGCCAGAGACAGAACC	0.388		NaN											0	0	0	0.001368	0	12	48									
KIAA1267	284058	broad.mit.edu	37	17	44144094	44144094	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:44144094G>A	uc002ikb.2	-	5	1742	c.1657C>T	c.(1657-1659)CAG>TAG	p.Q553*	KIAA1267_uc002ikc.2_Nonsense_Mutation_p.Q553*|KIAA1267_uc002ikd.2_Nonsense_Mutation_p.Q553*|KIAA1267_uc010dav.2_Nonsense_Mutation_p.Q553*	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	553						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				AAGACAGGCTGAAGACTATAC	0.338		NaN											0	0	0	0.001368	0	12	35									
PNPO	55163	broad.mit.edu	37	17	46023278	46023278	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:46023278T>C	uc002imo.2	+	5	622	c.469T>C	c.(469-471)TAC>CAC	p.Y157H	PNPO_uc010wkz.1_Missense_Mutation_p.Y139H|PNPO_uc010wla.1_Missense_Mutation_p.Y62H|PNPO_uc010wlb.1_Intron	NM_018129	NP_060599	Q9NVS9	PNPO_HUMAN	pyridoxine 5'-phosphate oxidase	157		Substrate.			pyridoxine biosynthetic process	cytosol	FMN binding|pyridoxamine-phosphate oxidase activity				0					Pyridoxal Phosphate(DB00114)	GGCTGAGTGCTACTTCCACTC	0.597		NaN											0	0	0	0.006122	0	19	42									
CACNA1G	8913	broad.mit.edu	37	17	48669297	48669297	+	Splice_Site	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:48669297G>T	uc002irk.1	+	13	3127	c.2755_splice	c.e13-1	p.I919_splice	CACNA1G_uc002iri.1_Splice_Site_p.I919_splice|CACNA1G_uc002irj.1_Splice_Site_p.I919_splice|CACNA1G_uc002irl.1_Splice_Site_p.I919_splice|CACNA1G_uc002irm.1_Splice_Site_p.I919_splice|CACNA1G_uc002irn.1_Splice_Site_p.I919_splice|CACNA1G_uc002iro.1_Splice_Site_p.I919_splice|CACNA1G_uc002irp.1_Splice_Site_p.I919_splice|CACNA1G_uc002irq.1_Splice_Site_p.I919_splice|CACNA1G_uc002irr.1_Splice_Site_p.I919_splice|CACNA1G_uc002irs.1_Splice_Site_p.I919_splice|CACNA1G_uc002irt.1_Splice_Site_p.I919_splice|CACNA1G_uc002irv.1_Splice_Site_p.I919_splice|CACNA1G_uc002irw.1_Splice_Site_p.I919_splice|CACNA1G_uc002iru.1_Splice_Site_p.I919_splice|CACNA1G_uc002irx.1_Splice_Site_p.I832_splice|CACNA1G_uc002iry.1_Splice_Site_p.I832_splice|CACNA1G_uc002irz.1_Splice_Site_p.I832_splice|CACNA1G_uc002isa.1_Splice_Site_p.I832_splice|CACNA1G_uc002isb.1_Splice_Site_p.I832_splice|CACNA1G_uc002isc.1_Splice_Site_p.I832_splice|CACNA1G_uc002isd.1_Splice_Site_p.I832_splice|CACNA1G_uc002ise.1_Splice_Site_p.I832_splice|CACNA1G_uc002isf.1_Splice_Site_p.I832_splice|CACNA1G_uc002isg.1_Splice_Site_p.I832_splice|CACNA1G_uc002ish.1_Splice_Site_p.I832_splice|CACNA1G_uc002isi.1_Splice_Site_p.I832_splice	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G						axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TCTGCCCGCAGATCCTGACCC	0.582		NaN											1	0	6.31663e-08	0.003163	7.68238e-08	15	12									
CACNA1G	8913	broad.mit.edu	37	17	48678510	48678510	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:48678510G>A	uc002irk.1	+	19	4262	c.3890G>A	c.(3889-3891)CGC>CAC	p.R1297H	CACNA1G_uc002iri.1_Missense_Mutation_p.R1297H|CACNA1G_uc002irj.1_Missense_Mutation_p.R1274H|CACNA1G_uc002irl.1_Missense_Mutation_p.R1274H|CACNA1G_uc002irm.1_Missense_Mutation_p.R1274H|CACNA1G_uc002irn.1_Missense_Mutation_p.R1274H|CACNA1G_uc002iro.1_Missense_Mutation_p.R1274H|CACNA1G_uc002irp.1_Missense_Mutation_p.R1297H|CACNA1G_uc002irq.1_Missense_Mutation_p.R1274H|CACNA1G_uc002irr.1_Missense_Mutation_p.R1297H|CACNA1G_uc002irs.1_Missense_Mutation_p.R1297H|CACNA1G_uc002irt.1_Missense_Mutation_p.R1297H|CACNA1G_uc002irv.1_Missense_Mutation_p.R1297H|CACNA1G_uc002irw.1_Missense_Mutation_p.R1274H|CACNA1G_uc002iru.1_Missense_Mutation_p.R1274H|CACNA1G_uc002irx.1_Missense_Mutation_p.R1210H|CACNA1G_uc002iry.1_Missense_Mutation_p.R1210H|CACNA1G_uc002irz.1_Missense_Mutation_p.R1210H|CACNA1G_uc002isa.1_Missense_Mutation_p.R1210H|CACNA1G_uc002isb.1_Missense_Mutation_p.R1210H|CACNA1G_uc002isc.1_Missense_Mutation_p.R1210H|CACNA1G_uc002isd.1_Missense_Mutation_p.R1210H|CACNA1G_uc002ise.1_Missense_Mutation_p.R1210H|CACNA1G_uc002isf.1_Missense_Mutation_p.R1210H|CACNA1G_uc002isg.1_Missense_Mutation_p.R1210H|CACNA1G_uc002ish.1_Missense_Mutation_p.R1210H|CACNA1G_uc002isi.1_Missense_Mutation_p.R1187H|CACNA1G_uc002isj.2_Missense_Mutation_p.R21H	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1297	Extracellular (Potential).|III.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCCATGGAGCGCCCCAAAATT	0.592		NaN											0	0	0	0.007291	0	31	35									
C17orf67	339210	broad.mit.edu	37	17	54893199	54893199	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:54893199G>A	uc010dci.2	-	1	52	c.45C>T	c.(43-45)CTC>CTT	p.L15L	C17orf67_uc002iuq.2_RNA	NM_001085430	NP_001078899	Q0P5P2	CQ067_HUMAN	hypothetical protein LOC339210 precursor	15						extracellular region					0	Breast(9;2.49e-06)					GCCTCTTGCTGAGTGAATCCT	0.517		NaN											0	0	0	0.006214	0	10	81									
CLTC	1213	broad.mit.edu	37	17	57743597	57743597	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:57743597C>G	uc002ixq.1	+	11	2221	c.1778C>G	c.(1777-1779)CCT>CGT	p.P593R	CLTC_uc002ixp.2_Missense_Mutation_p.P593R|CLTC_uc002ixr.1_Missense_Mutation_p.P597R	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	593	Heavy chain arm.|Distal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					ATGCATGCGCCTCAAGTATGT	0.433		NaN	T	ALK|TFE3	ALCL|renal 								0	0	0	0.000978	0	10	100									
CLTC	1213	broad.mit.edu	37	17	57754433	57754433	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:57754433C>G	uc002ixq.1	+	17	3123	c.2680C>G	c.(2680-2682)CTT>GTT	p.L894V	CLTC_uc002ixp.2_Missense_Mutation_p.L894V|CLTC_uc002ixr.1_Missense_Mutation_p.L898V	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	894	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GGAGAGATTTCTTCGTGAAAA	0.458		NaN	T	ALK|TFE3	ALCL|renal 								0	0	0	0.002222	0	43	58									
MED13	9969	broad.mit.edu	37	17	60108955	60108955	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:60108955G>A	uc002izo.2	-	6	936	c.859C>T	c.(859-861)CAG>TAG	p.Q287*	MED13_uc002izp.2_5'Flank	NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	287					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						ATGTCTGACTGAGGGACTAGA	0.468		NaN											0	0	0	0.000978	0	11	51									
MRC2	9902	broad.mit.edu	37	17	60743976	60743976	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:60743976C>G	uc002jad.2	+	4	1257	c.855C>G	c.(853-855)ATC>ATG	p.I285M	MRC2_uc002jac.2_Missense_Mutation_p.I285M	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	285	Extracellular (Potential).|C-type lectin 1.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						AGACCTACATCAACGGTGAGC	0.677		NaN											0	0	0	0.000248	0	4	18									
MRC2	9902	broad.mit.edu	37	17	60767311	60767311	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:60767311G>A	uc002jad.2	+	25	4032	c.3630G>A	c.(3628-3630)CAG>CAA	p.Q1210Q	MRC2_uc002jae.2_Silent_p.Q281Q|MRC2_uc002jaf.2_Silent_p.Q76Q	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	1210	Extracellular (Potential).|C-type lectin 7.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						TGGGCTGGCAGGACGGGGAGC	0.677		NaN											0	0	0	0.000602	0	5	38									
GNA13	10672	broad.mit.edu	37	17	63052692	63052692	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:63052692G>A	uc002jfc.2	-	1	229	c.20C>T	c.(19-21)TCG>TTG	p.S7L	GNA13_uc010wqh.1_5'Flank	NM_006572	NP_006563	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein),	7					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding				0						CACGGACCGCGACGGCAGGAA	0.587		NaN											0	0	0	0.00361	0	94	114									
FAM20A	54757	broad.mit.edu	37	17	66550954	66550954	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:66550954C>T	uc002jho.2	-	3	892	c.604G>A	c.(604-606)GAG>AAG	p.E202K	FAM20A_uc010wqp.1_Missense_Mutation_p.E64K|FAM20A_uc002jhn.2_5'UTR	NM_017565	NP_060035	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	202						extracellular region					0	Breast(10;1.64e-13)					AAGGCTTTCTCATCTTGACTG	0.542		NaN											0	0	0	0.00874	0	39	39									
ABCA8	10351	broad.mit.edu	37	17	66899010	66899010	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:66899010G>C	uc002jhp.2	-	19	2667	c.2488C>G	c.(2488-2490)CTA>GTA	p.L830V	ABCA8_uc002jhq.2_Missense_Mutation_p.L870V|ABCA8_uc010wqq.1_Missense_Mutation_p.L870V|ABCA8_uc010wqr.1_Missense_Mutation_p.L809V|ABCA8_uc002jhr.2_Missense_Mutation_p.L870V	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	830	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					CCAGCCATTAGAATTAATAGC	0.348		NaN											0	0	0	0.003954	0	20	106									
ABCA8	10351	broad.mit.edu	37	17	66925208	66925208	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:66925208G>A	uc002jhp.2	-	8	1286	c.1107C>T	c.(1105-1107)TTC>TTT	p.F369F	ABCA8_uc002jhq.2_Silent_p.F369F|ABCA8_uc010wqq.1_Silent_p.F369F|ABCA8_uc010wqr.1_Silent_p.F308F|ABCA8_uc002jhr.2_Silent_p.F369F	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	369	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					TTCCAAGCATGAAGGCAAAGG	0.458		NaN											0	0	0	0.00632	0	24	76									
ABCA9	10350	broad.mit.edu	37	17	66980209	66980209	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:66980209G>A	uc002jhu.2	-	35	4630	c.4487C>T	c.(4486-4488)TCA>TTA	p.S1496L	ABCA9_uc010dez.2_Missense_Mutation_p.S1458L	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1496	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					CAGCCTTCCTGACACCATGAT	0.597		NaN											0	0	0	0.004656	0	24	110									
KCTD2	23510	broad.mit.edu	37	17	73055613	73055613	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:73055613G>A	uc002jmp.2	+	4	616	c.549G>A	c.(547-549)GTG>GTA	p.V183V	KCTD2_uc010dfz.2_RNA|KCTD2_uc002jmq.2_RNA	NM_015353	NP_056168	Q14681	KCTD2_HUMAN	potassium channel tetramerisation domain	183						voltage-gated potassium channel complex	voltage-gated potassium channel activity				0	all_lung(278;0.226)					AGGGCCCCGTGAAGCACGTGT	0.527		NaN											0	0	0	0.003163	0	16	38									
SRP68	6730	broad.mit.edu	37	17	74056437	74056437	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:74056437C>T	uc002jqk.1	-	7	824	c.789G>A	c.(787-789)ATG>ATA	p.M263I	SRP68_uc010wsu.1_Missense_Mutation_p.M162I|SRP68_uc002jql.1_Missense_Mutation_p.M225I	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	263					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						ACCTCAATCTCATCTGCATGA	0.428		NaN											0	0	0	0.003954	0	19	96									
SRP68	6730	broad.mit.edu	37	17	74068563	74068563	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:74068563C>T	uc002jqk.1	-	1	45	c.10G>A	c.(10-12)GAG>AAG	p.E4K	SRP68_uc010wsu.1_5'UTR|SRP68_uc002jql.1_Missense_Mutation_p.E4K|GALR2_uc002jqm.1_5'Flank	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	4					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						ACCTGCTTCTCAGCAGCCATC	0.463		NaN											0	0	0	0.00278	0	23	80									
UBE2O	63893	broad.mit.edu	37	17	74387651	74387651	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:74387651G>A	uc002jrm.3	-	18	3317	c.3252C>T	c.(3250-3252)TTC>TTT	p.F1084F	UBE2O_uc002jrl.3_Silent_p.F688F	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	1084							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						GGTCACTGTCGAAGCCGGCTT	0.577		NaN											0	0	0	0.00361	0	45	121									
SFRS2	6427	broad.mit.edu	37	17	74732523	74732523	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:74732523C>A	uc002jsv.2	-	2	556	c.386G>T	c.(385-387)CGA>CTA	p.R129L	SFRS2_uc002jsw.1_RNA|SFRS2_uc002jsx.1_RNA|SFRS2_uc002jsy.3_Missense_Mutation_p.R129L|SFRS2_uc010wtg.1_Missense_Mutation_p.R117L|MFSD11_uc002jsz.1_RNA|MFSD11_uc002jta.2_5'UTR|MFSD11_uc002jtb.2_5'Flank|MFSD11_uc010dha.2_5'Flank|MFSD11_uc002jtc.2_5'Flank|MFSD11_uc002jtd.3_5'Flank|MFSD11_uc010dhb.2_5'Flank|MFSD11_uc002jte.2_5'Flank	NM_003016	NP_003007	Q01130	SRSF2_HUMAN	splicing factor, arginine/serine-rich 2	129	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity				0						ACTCCGGGATCGGCTGCGGCG	0.552		NaN											1	0	1.49906e-05	0.00245	1.80187e-05	13	66									
DNAH17	8632	broad.mit.edu	37	17	76451810	76451810	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:76451810G>A	uc010dhp.1	-	8	1308	c.1086C>T	c.(1084-1086)TTC>TTT	p.F362F	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CGTAGGACACGAAGGCAGAGA	0.522		NaN											0	0	0	0.004482	0	9	21									
EIF4A3	9775	broad.mit.edu	37	17	78115614	78115614	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:78115614G>A	uc010wuc.1	-	4	349	c.276C>T	c.(274-276)TTC>TTT	p.F92F	EIF4A3_uc002jxs.2_Silent_p.F92F	NM_014740	NP_055555	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A,	92	Helicase ATP-binding.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			CTGAGATACTGAAGGTGGCTG	0.438		NaN											0	0	0	0.006122	0	17	42									
EIF4A3	9775	broad.mit.edu	37	17	78115643	78115643	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:78115643G>A	uc010wuc.1	-	4	320	c.247C>T	c.(247-249)CAG>TAG	p.Q83*	EIF4A3_uc002jxs.2_Nonsense_Mutation_p.Q83*	NM_014740	NP_055555	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A,	83	Helicase ATP-binding.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			GTGCCGGACTGAGACCTATTC	0.478		NaN											0	0	0	0.001368	0	12	42									
RNF213	57674	broad.mit.edu	37	17	78359383	78359383	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:78359383C>G	uc002jyh.1	+	36	8943	c.8720C>G	c.(8719-8721)TCC>TGC	p.S2907C	uc002jyi.1_Intron|RNF213_uc010dhx.1_5'Flank	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	1200										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GTCTTTCTGTCCACATGGAAC	0.498		NaN											0	0	0	0.001368	0	10	44									
SLC38A10	124565	broad.mit.edu	37	17	79263557	79263557	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:79263557G>A	uc002jzz.1	-	2	526	c.151C>T	c.(151-153)CAC>TAC	p.H51Y	SLC38A10_uc002kab.2_Missense_Mutation_p.H51Y	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	51	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CACGACTGGTGCGTCATCCAT	0.632		NaN											0	0	0	0.004007	0	15	35									
EPB41L3	23136	broad.mit.edu	37	18	5398076	5398076	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:5398076G>A	uc002kmt.1	-	17	2502	c.2416C>T	c.(2416-2418)CGA>TGA	p.R806*	EPB41L3_uc010wzh.1_Nonsense_Mutation_p.R637*|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Nonsense_Mutation_p.R111*|EPB41L3_uc010wzf.1_Nonsense_Mutation_p.R103*|EPB41L3_uc010wzg.1_Nonsense_Mutation_p.R78*|EPB41L3_uc010dkr.2_Nonsense_Mutation_p.R198*	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	806	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GTTGGTTTTCGCGCAGACTCT	0.453		NaN											0	0	0	0.00361	0	45	306									
ANKRD12	23253	broad.mit.edu	37	18	9255144	9255144	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:9255144G>A	uc002knv.2	+	9	2136	c.1879G>A	c.(1879-1881)GAA>AAA	p.E627K	ANKRD12_uc002knw.2_Missense_Mutation_p.E604K|ANKRD12_uc002knx.2_Missense_Mutation_p.E604K|ANKRD12_uc010dkx.1_Missense_Mutation_p.E334K	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	627						nucleus				ovary(2)|central_nervous_system(1)	3						AATAAAGGATGAAGATCATAG	0.184		NaN											0	0	0	0.00278	0	25	82									
PSMG2	56984	broad.mit.edu	37	18	12706694	12706694	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:12706694C>G	uc002krk.2	+	2	246	c.203C>G	c.(202-204)TCA>TGA	p.S68*	PSMG2_uc002krg.2_Nonsense_Mutation_p.S37*|PSMG2_uc002krj.1_Nonsense_Mutation_p.S68*	NM_020232	NP_064617	Q969U7	PSMG2_HUMAN	proteasome (prosome, macropain) assembly	68					proteasome assembly	nucleus	protein binding				0						GAAGGAAATTCAACAGAACTT	0.323		NaN											0	0	0	0.002299	0	22	56									
GATA6	2627	broad.mit.edu	37	18	19780746	19780746	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:19780746C>A	uc002ktt.1	+	7	2013	c.1748C>A	c.(1747-1749)TCC>TAC	p.S583Y	GATA6_uc002ktu.1_Missense_Mutation_p.S583Y	NM_005257	NP_005248	Q92908	GATA6_HUMAN	GATA binding protein 6	583					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(3)	3	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			GTCACGTCCTCCGTGCGACCG	0.672		NaN											1	0	2.79863e-10	0.004656	3.46223e-10	27	253									
RBBP8	5932	broad.mit.edu	37	18	20564853	20564853	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:20564853G>A	uc002ktw.2	+	8	940	c.609G>A	c.(607-609)ATG>ATA	p.M203I	RBBP8_uc002kty.2_Missense_Mutation_p.M203I|RBBP8_uc002ktz.2_Missense_Mutation_p.M203I|RBBP8_uc002kua.2_Missense_Mutation_p.M203I|RBBP8_uc002ktx.1_Missense_Mutation_p.M203I	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	203					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			CCTTAGAAATGAGAAAAGTTT	0.274		NaN						Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.006214	0	9	61									
LAMA3	3909	broad.mit.edu	37	18	21494446	21494446	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:21494446G>C	uc002kuq.2	+	57	7488	c.7402G>C	c.(7402-7404)GAG>CAG	p.E2468Q	LAMA3_uc002kur.2_Missense_Mutation_p.E2412Q|LAMA3_uc002kus.3_Missense_Mutation_p.E859Q|LAMA3_uc002kut.3_Missense_Mutation_p.E803Q	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2468	Laminin G-like 1.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGGGACCGTGAGGCTGAACT	0.537		NaN											0	0	0	0.001168	0	5	72									
DSC2	1824	broad.mit.edu	37	18	28673588	28673588	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:28673588C>G	uc002kwl.3	-	2	542	c.88G>C	c.(88-90)GAT>CAT	p.D30H	DSC2_uc002kwk.3_Missense_Mutation_p.D30H|DSC2_uc010xbo.1_Missense_Mutation_p.D30H	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	30					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TTGCAGGCATCACTGGCAAAT	0.259		NaN											0	0	0	0.00361	0	54	135									
DSG2	1829	broad.mit.edu	37	18	29126602	29126602	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:29126602C>G	uc002kwu.3	+	15	3441	c.3253C>G	c.(3253-3255)CTG>GTG	p.L1085V	uc002kwv.3_Intron	NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	1085	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			CCCTGGCCCTCTGCCAGATTT	0.478		NaN											0	0	0	0.003954	0	24	85									
MCART2	147407	broad.mit.edu	37	18	29340499	29340499	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:29340499G>T	uc002kxa.2	-	1	345	c.126C>A	c.(124-126)TTC>TTA	p.F42L		NM_001034172	NP_001029344	Q3SY17	MCAR2_HUMAN	mitochondrial carrier triple repeat 2	42	Solcar 1.|Helical; Name=1; (Potential).				transport	integral to membrane|mitochondrial inner membrane				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(10;0.0539)			CGACGTTGTTGAAGGCTGCAC	0.438		NaN											1	0	6.03219e-31	0.00361	7.7075e-31	49	126									
FAM59A	64762	broad.mit.edu	37	18	29848662	29848662	+	Silent	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:29848662C>A	uc002kxl.2	-	6	1859	c.1803G>T	c.(1801-1803)GTG>GTT	p.V601V	FAM59A_uc002kxk.1_Silent_p.V600V	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	601										ovary(1)|skin(1)	2						AATCAGTTTTCACTCGGTTAC	0.458		NaN											1	0	1.05317e-09	0.00245	1.29843e-09	15	46									
CELF4	56853	broad.mit.edu	37	18	34839145	34839145	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:34839145G>A	uc002lae.2	-	11	1728	c.1332C>T	c.(1330-1332)TTC>TTT	p.F444F	CELF4_uc010dnd.1_Silent_p.F442F|CELF4_uc002lag.2_Intron|CELF4_uc002laf.2_Silent_p.F438F|CELF4_uc002lai.2_Silent_p.F428F	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	444	RRM 3.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						TGACATTACCGAAAGGGAGGA	0.488		NaN											0	0	0	0.005443	0	24	61									
SLC14A2	8170	broad.mit.edu	37	18	43221187	43221187	+	Silent	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:43221187C>A	uc010dnj.2	+	9	1326	c.1005C>A	c.(1003-1005)GCC>GCA	p.A335A	SLC14A2_uc002lbb.2_Silent_p.A335A|SLC14A2_uc002lbe.2_Silent_p.A335A	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	335						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						TGTCAGTGGCCACACCCTTCG	0.577		NaN											1	0	6.81908e-15	0.00245	8.55355e-15	14	136									
TCEB3B	51224	broad.mit.edu	37	18	44559892	44559892	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:44559892C>G	uc002lcr.1	-	1	2097	c.1744G>C	c.(1744-1746)GAC>CAC	p.D582H	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	582	Activation domain (By similarity).				regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CGTAATTCGTCTGTCTCTCTA	0.517		NaN											0	0	0	0.004482	0	8	77									
IER3IP1	51124	broad.mit.edu	37	18	44702592	44702592	+	Silent	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:44702592G>T	uc002lcu.2	-	1	154	c.57C>A	c.(55-57)ATC>ATA	p.I19I		NM_016097	NP_057181	Q9Y5U9	IR3IP_HUMAN	immediate early response 3 interacting protein	19	Helical; (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane					0						GCAGCACTGCGATGGCGTTGA	0.468		NaN											1	0	3.59834e-05	0.001168	4.30724e-05	6	16									
SKA1	220134	broad.mit.edu	37	18	47918545	47918545	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:47918545G>A	uc002let.2	+	7	880	c.696G>A	c.(694-696)CTG>CTA	p.L232L	SKA1_uc002leu.2_Silent_p.L232L|SKA1_uc010xdl.1_Silent_p.L186L	NM_145060	NP_659497	Q96BD8	SKA1_HUMAN	spindle and KT associated 1	232					cell division|chromosome segregation|mitotic anaphase|mitotic prometaphase|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytosol|spindle microtubule	microtubule binding				0						ACGTGTTACTGAATATTTTAC	0.393		NaN											0	0	0	0.003271	0	33	82									
ATP8B1	5205	broad.mit.edu	37	18	55322535	55322535	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:55322535C>T	uc002lgw.2	-	22	2822	c.2822G>A	c.(2821-2823)CGA>CAA	p.R941Q	uc002lgu.1_Intron|uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	941	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				GTAAGACCATCGGCCATGCAC	0.433		NaN							Byler_disease				0	0	0	0.007291	0	30	96									
ZNF532	55205	broad.mit.edu	37	18	56585882	56585882	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:56585882G>A	uc002lho.2	+	4	910	c.363G>A	c.(361-363)CTG>CTA	p.L121L	ZNF532_uc002lhp.2_Silent_p.L119L|ZNF532_uc010xeg.1_Silent_p.L119L|ZNF532_uc002lhr.2_Silent_p.L119L|ZNF532_uc002lhs.2_Silent_p.L119L	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						AGGTGACACTGAAAGACTCGA	0.493		NaN											0	0	0	0.002299	0	21	97									
SERPINB8	5271	broad.mit.edu	37	18	61647057	61647057	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:61647057G>A	uc002ljv.2	+	3	360	c.191G>A	c.(190-192)GGA>GAA	p.G64E	SERPINB8_uc002ljs.1_Missense_Mutation_p.G64E|SERPINB8_uc002ljt.2_Missense_Mutation_p.G64E|SERPINB8_uc002lju.2_Missense_Mutation_p.G64E|SERPINB8_uc010xex.1_5'UTR	NM_198833	NP_942130	P50452	SPB8_HUMAN	serine (or cysteine) proteinase inhibitor, clade	64					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)				TACAAAGACGGAGATATTCAC	0.433		NaN									OREG0025042	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003755	0	33	108									
PARD6G	84552	broad.mit.edu	37	18	77917935	77917935	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:77917935C>T	uc002lny.2	-	3	1016	c.850G>A	c.(850-852)GTC>ATC	p.V284I	LOC100130522_uc002lnx.2_Intron|LOC100130522_uc010xfn.1_Intron|LOC100130522_uc010xfo.1_Intron	NM_032510	NP_115899	Q9BYG4	PAR6G_HUMAN	PAR-6 gamma protein	284					cell cycle|cell division|tight junction assembly	cytosol|tight junction	protein binding				0		all_cancers(4;5.63e-22)|all_epithelial(4;5.86e-15)|all_lung(4;1.32e-05)|Ovarian(4;1.33e-05)|Lung NSC(4;2.77e-05)|Esophageal squamous(42;0.0157)|all_hematologic(56;0.13)|Melanoma(33;0.144)		Epithelial(2;1.48e-13)|all cancers(1;5.77e-13)|OV - Ovarian serous cystadenocarcinoma(15;2.74e-10)|BRCA - Breast invasive adenocarcinoma(31;0.00166)|STAD - Stomach adenocarcinoma(84;0.18)|Lung(128;0.23)		TTCTGCAGGACGCGCGGGGCG	0.731		NaN											0	0	0	0.000602	0	5	18									
ABCA7	10347	broad.mit.edu	37	19	1043124	1043124	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:1043124G>A	uc002lqw.3	+	8	895	c.664G>A	c.(664-666)GAG>AAG	p.E222K	ABCA7_uc010dsb.1_Missense_Mutation_p.E84K	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	222	Extracellular (By similarity).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTTGCTGTCAGAGGCCCTCTG	0.657		NaN											0	0	0	0.003163	0	15	68									
HMHA1	23526	broad.mit.edu	37	19	1068607	1068607	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:1068607G>A	uc002lqz.1	+	2	516	c.285G>A	c.(283-285)CTG>CTA	p.L95L	HMHA1_uc010xgd.1_Silent_p.L111L|HMHA1_uc010xge.1_Intron|HMHA1_uc002lra.1_5'UTR|HMHA1_uc002lrb.1_5'Flank	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	95					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGCCCACTGACAGCCGCCA	0.741		NaN											0	0	0	0.00308	0	8	30									
ZNF555	148254	broad.mit.edu	37	19	2853858	2853858	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:2853858C>T	uc002lwo.2	+	4	1884	c.1795C>T	c.(1795-1797)CCT>TCT	p.P599S	ZNF555_uc002lwn.3_Missense_Mutation_p.P598S	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	599					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTAGGACATCCTCCTGCAAA	0.388		NaN											0	0	0	0.004007	0	15	87									
ZNF556	80032	broad.mit.edu	37	19	2873567	2873567	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:2873567G>C	uc002lwp.1	+	2	164	c.77G>C	c.(76-78)AGA>ACA	p.R26T	ZNF556_uc002lwq.2_Missense_Mutation_p.R26T	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	26	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGCTCAGAGAAAACTCTAC	0.438		NaN											0	0	0	0.008361	0	30	93									
CHAF1A	10036	broad.mit.edu	37	19	4408975	4408975	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:4408975C>T	uc002mal.2	+	3	279	c.179C>T	c.(178-180)TCT>TTT	p.S60F		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	60	Binds to CBX1 chromo shadow domain.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGGTACTTCTGTGCAAAGT	0.473		NaN						Chromatin_Structure					0	0	0	0.00361	0	69	145									
UBXN6	80700	broad.mit.edu	37	19	4453979	4453979	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:4453979C>T	uc002man.1	-	2	291	c.195G>A	c.(193-195)CAG>CAA	p.Q65Q	UBXN6_uc010dty.1_Silent_p.Q12Q|UBXN6_uc002mam.1_Silent_p.Q12Q	NM_025241	NP_079517	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	65						microtubule organizing center|nucleus	protein binding				0						GGGACTGCTTCTGCTCCAGCC	0.672		NaN											0	0	0	0.00361	0	48	127									
LONP1	9361	broad.mit.edu	37	19	5694465	5694465	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:5694465G>A	uc002mcx.2	-	15	2286	c.2253C>T	c.(2251-2253)TTC>TTT	p.F751F	LONP1_uc002mcy.2_Silent_p.F687F|LONP1_uc010duh.2_Silent_p.F492F|LONP1_uc010dui.2_Silent_p.F735F|LONP1_uc002mcz.2_Silent_p.F555F	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	751					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						GCTCCACGGTGAACACGGGCT	0.642		NaN											0	0	0	0.001168	0	5	63									
EMR1	2015	broad.mit.edu	37	19	6928195	6928195	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:6928195C>T	uc002mfw.2	+	17	2300	c.2262C>T	c.(2260-2262)TTC>TTT	p.F754F	EMR1_uc010dvc.2_Silent_p.F689F|EMR1_uc010dvb.2_Silent_p.F702F|EMR1_uc010xji.1_Silent_p.F613F|EMR1_uc010xjj.1_Silent_p.F577F	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	754	Helical; Name=5; (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					TCTGGAGTTTCTTGGGGCCAG	0.498		NaN											0	0	0	0.00361	0	45	116									
C19orf45	374877	broad.mit.edu	37	19	7569023	7569023	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:7569023C>T	uc002mgm.2	+	3	735	c.594C>T	c.(592-594)CTC>CTT	p.L198L	C19orf45_uc010xjo.1_5'Flank	NM_198534	NP_940936	Q8NA69	CS045_HUMAN	hypothetical protein LOC374877	198											0						CCAACACCCTCAAGTGGGACT	0.547		NaN											0	0	0	0.00308	0	7	34									
MAP2K7	5609	broad.mit.edu	37	19	7968919	7968919	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:7968919C>G	uc002mit.2	+	1	155	c.90C>G	c.(88-90)CTC>CTG	p.L30L	MAP2K7_uc002mis.1_Silent_p.L30L|MAP2K7_uc002miv.2_Silent_p.L30L|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Silent_p.L30L|MAP2K7_uc010dvv.2_5'UTR	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	30	Potential.				activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)	GGATCGACCTCAACCTGGATA	0.398		NaN											0	0	0	0.004482	0	8	30									
ELAVL1	1994	broad.mit.edu	37	19	8032455	8032455	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:8032455C>G	uc002mjb.2	-	5	817	c.650G>C	c.(649-651)AGA>ACA	p.R217T		NM_001419	NP_001410	Q15717	ELAV1_HUMAN	ELAV-like 1	217					3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0						CCACCTGAATCTCTGCGCCTG	0.622		NaN											0	0	0	0.004482	0	8	24									
MUC16	94025	broad.mit.edu	37	19	9084097	9084097	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:9084097G>A	uc002mkp.2	-	1	7922	c.7718C>T	c.(7717-7719)TCT>TTT	p.S2573F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2573	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGTGGTGAAGAATGAATGGC	0.502		NaN											0	0	0	0.00632	0	28	102									
MUC16	94025	broad.mit.edu	37	19	9086405	9086405	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:9086405C>T	uc002mkp.2	-	1	5614	c.5410G>A	c.(5410-5412)GAA>AAA	p.E1804K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1804	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCTGTATTTTCAGTGCTTCCC	0.463		NaN											0	0	0	0.004656	0	27	69									
MUC16	94025	broad.mit.edu	37	19	9090786	9090786	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:9090786G>C	uc002mkp.2	-	1	1233	c.1029C>G	c.(1027-1029)GTC>GTG	p.V343V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	343	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTGTGCTTCTGACCCTTTCGG	0.507		NaN											0	0	0	0.003163	0	16	51									
DNMT1	1786	broad.mit.edu	37	19	10250949	10250949	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:10250949G>A	uc002mng.2	-	32	3711	c.3531C>T	c.(3529-3531)TTC>TTT	p.F1177F	DNMT1_uc002mne.2_RNA|DNMT1_uc002mnf.2_Silent_p.F101F|DNMT1_uc010xlc.1_Silent_p.F1193F|DNMT1_uc002mnh.2_Silent_p.F1072F|DNMT1_uc010xld.1_Silent_p.F1177F	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	1177	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TGTTCAGCCGGAACGCCTGGG	0.612		NaN											0	0	0	0.00499	0	17	55									
S1PR2	9294	broad.mit.edu	37	19	10335096	10335096	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:10335096G>A	uc002mnl.2	-	2	597	c.486C>T	c.(484-486)CTC>CTT	p.L162L		NM_004230	NP_004221	O95136	S1PR2_HUMAN	endothelial differentiation, sphingolipid	162	Helical; Name=4; (By similarity).				activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|central_nervous_system(1)	2						GCAGGCCACCGAGGACCAGCG	0.627		NaN											0	0	0	0.002299	0	22	54									
TYK2	7297	broad.mit.edu	37	19	10461569	10461569	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:10461569G>A	uc002moc.3	-	25	3883	c.3505C>T	c.(3505-3507)CTG>TTG	p.L1169L	TYK2_uc010dxe.2_Silent_p.L984L	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	1169	Protein kinase 2.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			ACTGTCTTCAGAATGGGTATG	0.557		NaN											0	0	0	0.00278	0	23	80									
SMARCA4	6597	broad.mit.edu	37	19	11121153	11121153	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:11121153G>A	uc002mqf.3	+	15	2504	c.2220G>A	c.(2218-2220)GAG>GAA	p.E740E	SMARCA4_uc010dxp.2_Silent_p.E740E|SMARCA4_uc010dxo.2_Silent_p.E740E|SMARCA4_uc002mqg.1_Silent_p.E740E|SMARCA4_uc010dxq.2_Silent_p.E740E|SMARCA4_uc010dxr.2_Silent_p.E740E|SMARCA4_uc002mqj.3_Silent_p.E740E|SMARCA4_uc010dxs.2_Silent_p.E740E|SMARCA4_uc010dxt.1_5'Flank	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	740					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CTGTCACTGAGAGAGTGGACA	0.587		NaN	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.002445	0	32	76									
SMARCA4	6597	broad.mit.edu	37	19	11121155	11121155	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:11121155G>A	uc002mqf.3	+	15	2506	c.2222G>A	c.(2221-2223)AGA>AAA	p.R741K	SMARCA4_uc010dxp.2_Missense_Mutation_p.R741K|SMARCA4_uc010dxo.2_Missense_Mutation_p.R741K|SMARCA4_uc002mqg.1_Missense_Mutation_p.R741K|SMARCA4_uc010dxq.2_Missense_Mutation_p.R741K|SMARCA4_uc010dxr.2_Missense_Mutation_p.R741K|SMARCA4_uc002mqj.3_Missense_Mutation_p.R741K|SMARCA4_uc010dxs.2_Missense_Mutation_p.R741K|SMARCA4_uc010dxt.1_5'Flank	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	741					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GTCACTGAGAGAGTGGACAAG	0.582		NaN	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.002836	0	33	77									
KANK2	25959	broad.mit.edu	37	19	11277264	11277264	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:11277264C>G	uc010dxv.2	-	15	3084	c.2526G>C	c.(2524-2526)GAG>GAC	p.E842D	KANK2_uc002mqm.2_Missense_Mutation_p.E850D|KANK2_uc002mqo.3_Missense_Mutation_p.E842D	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	842											0						ATGTAGGGCTCTCGTCATCTG	0.587		NaN											0	0	0	0.001368	0	11	71									
ZNF441	126068	broad.mit.edu	37	19	11892012	11892012	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:11892012C>G	uc010dyj.2	+	4	1567	c.1373C>G	c.(1372-1374)TCT>TGT	p.S458C	ZNF441_uc002msn.3_Missense_Mutation_p.S414C	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	458	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GCCTTCAGGTCTTCCAATTAC	0.398		NaN											0	0	0	0.005443	0	28	43									
ZNF441	126068	broad.mit.edu	37	19	11892189	11892189	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:11892189C>T	uc010dyj.2	+	4	1744	c.1550C>T	c.(1549-1551)TCA>TTA	p.S517L	ZNF441_uc002msn.3_Missense_Mutation_p.S473L	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	517	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCTCCCAGTTCATTTCGAAGA	0.398		NaN											0	0	0	0.001786	0	32	61									
ZNF433	163059	broad.mit.edu	37	19	12125889	12125889	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:12125889G>C	uc002msy.1	-	4	1964	c.1793C>G	c.(1792-1794)TCT>TGT	p.S598C	uc002msx.1_Intron|ZNF433_uc002msz.1_Missense_Mutation_p.S563C	NM_001080411	NP_001073880	Q8N7K0	ZN433_HUMAN	zinc finger protein 433	598	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACATCCAAAAGACTTCCCACA	0.468		NaN											0	0	0	0.001786	0	30	125									
ZNF433	163059	broad.mit.edu	37	19	12126042	12126042	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:12126042G>T	uc002msy.1	-	4	1811	c.1640C>A	c.(1639-1641)TCA>TAA	p.S547*	uc002msx.1_Intron|ZNF433_uc002msz.1_Nonsense_Mutation_p.S512*	NM_001080411	NP_001073880	Q8N7K0	ZN433_HUMAN	zinc finger protein 433	547	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTGAAGCTGTGAGGCAGATCT	0.453		NaN											1	0	2.4375e-19	0.007291	3.08979e-19	30	112									
ZNF791	163049	broad.mit.edu	37	19	12739289	12739289	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:12739289C>G	uc002mua.2	+	4	1108	c.946C>G	c.(946-948)CAA>GAA	p.Q316E	ZNF791_uc010xml.1_Missense_Mutation_p.Q284E|ZNF791_uc010dyu.1_Missense_Mutation_p.Q207E|ZNF791_uc010xmm.1_Missense_Mutation_p.Q207E	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	316	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CACCTCCATTCAAATTCATGA	0.393		NaN											0	0	0	0.001855	0	11	54									
JUNB	3726	broad.mit.edu	37	19	12903392	12903392	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:12903392C>G	uc002mvc.2	+	1	1083	c.807C>G	c.(805-807)ATC>ATG	p.I269M	JUNB_uc002mvb.2_RNA	NM_002229	NP_002220	P17275	JUNB_HUMAN	jun B proto-oncogene	269						chromatin|nucleus	protein dimerization activity|transcription coactivator activity|transcription corepressor activity			lung(2)|central_nervous_system(1)	3						AAGAGCGCATCAAAGTGGAGC	0.682		NaN											0	0	0	0.004672	0	2	8									
GCDH	2639	broad.mit.edu	37	19	13007200	13007200	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:13007200G>C	uc002mvq.2	+	8	894	c.817G>C	c.(817-819)GAG>CAG	p.E273Q	GCDH_uc010xms.1_Missense_Mutation_p.E240Q|GCDH_uc002mvp.2_Missense_Mutation_p.E273Q|GCDH_uc010xmt.1_Missense_Mutation_p.E107Q|GCDH_uc010xmu.1_Missense_Mutation_p.E229Q	NM_000159	NP_000150	Q92947	GCDH_HUMAN	glutaryl-Coenzyme A dehydrogenase isoform a	273					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding				0						GGAGGTGCCAGAGGAGAATGT	0.632		NaN											0	0	0	0.001984	0	5	35									
TRMT1	55621	broad.mit.edu	37	19	13218411	13218411	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:13218411G>A	uc002mwj.2	-	13	1810	c.1560C>T	c.(1558-1560)TTC>TTT	p.F520F	TRMT1_uc010xmy.1_Silent_p.F124F|TRMT1_uc002mwk.2_Silent_p.F491F|TRMT1_uc002mwl.3_Silent_p.F520F|TRMT1_uc010xmz.1_Silent_p.F306F	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	520							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		TGAGAATGCGGAACGCTGGGC	0.582		NaN											0	0	0	0.006214	0	8	11									
BRD4	23476	broad.mit.edu	37	19	15349940	15349940	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:15349940C>T	uc002nar.2	-	18	3934	c.3712G>A	c.(3712-3714)GAG>AAG	p.E1238K		NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	1238					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			AGGGCCTTCTCACGCTCCTCT	0.662		NaN	T	NUT|C15orf55	lethal midline carcinoma of young people								0	0	0	0.001368	0	12	11									
CYP4F3	4051	broad.mit.edu	37	19	15760750	15760750	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:15760750C>G	uc002nbj.2	+	7	725	c.675C>G	c.(673-675)ATC>ATG	p.I225M	CYP4F3_uc010xok.1_Missense_Mutation_p.I225M|CYP4F3_uc010xol.1_Missense_Mutation_p.I225M|CYP4F3_uc010xom.1_Missense_Mutation_p.I76M|CYP4F3_uc002nbk.2_Missense_Mutation_p.I225M|CYP4F3_uc010xon.1_5'Flank	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	225					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						TTGCCGCCATCTTGGAGCTCA	0.522		NaN											0	0	0	0.00361	0	63	221									
GTPBP3	84705	broad.mit.edu	37	19	17452360	17452360	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:17452360G>A	uc010eas.2	+	9	1392	c.1327G>A	c.(1327-1329)GAT>AAT	p.D443N	GTPBP3_uc010xpo.1_Missense_Mutation_p.D465N|GTPBP3_uc002ngh.3_Missense_Mutation_p.D422N|GTPBP3_uc002ngg.3_Missense_Mutation_p.D475N|GTPBP3_uc002ngi.3_Missense_Mutation_p.D109N	NM_032620	NP_116009	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial) isoform V	443					tRNA modification	mitochondrion	GTP binding|GTPase activity			skin(1)	1						GGGTTGCCTGGATGCCCTCGG	0.642		NaN											0	0	0	0.008291	0	11	72									
PGLS	25796	broad.mit.edu	37	19	17631815	17631815	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:17631815G>A	uc002ngw.2	+	5	752	c.702G>A	c.(700-702)GGG>GGA	p.G234G	FAM129C_uc010xpq.1_5'Flank|FAM129C_uc010xpr.1_5'Flank	NM_012088	NP_036220	O95336	6PGL_HUMAN	6-phosphogluconolactonase	234						cytosol	6-phosphogluconolactonase activity				0						CCCACACCGGGAAACTGTGCT	0.652		NaN											0	0	0	0.000602	0	5	9									
MAP1S	55201	broad.mit.edu	37	19	17838864	17838864	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:17838864G>A	uc002nhe.1	+	5	2680	c.2671G>A	c.(2671-2673)GGT>AGT	p.G891S	MAP1S_uc010eba.1_Intron|MAP1S_uc002nhf.1_Missense_Mutation_p.G139S|MAP1S_uc010xpv.1_Missense_Mutation_p.G865S	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	891	Necessary for interaction with RASSF1 isoform A and isoform C.|Necessary for association with microtubules.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						GGGGCTTGCTGGTGGGGACCG	0.682		NaN											0	0	0	0.008291	0	10	26									
UBA52	7311	broad.mit.edu	37	19	18684102	18684102	+	Splice_Site	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:18684102G>A	uc002njr.2	+	2	107	c.-7_splice	c.e2-1		UBA52_uc002njs.2_Splice_Site|UBA52_uc002njt.2_Splice_Site	NM_001033930	NP_001029102	P62987	RL40_HUMAN	ubiquitin and ribosomal protein L40 precursor						activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane|ribosome	protein binding|structural constituent of ribosome				0						TCCTCCTGCAGACGCAAACAT	0.517		NaN											0	0	0	0.001984	0	6	28									
NCAN	1463	broad.mit.edu	37	19	19334931	19334931	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:19334931C>G	uc002nlz.2	+	4	676	c.577C>G	c.(577-579)CGG>GGG	p.R193G	NCAN_uc010ecc.1_5'Flank	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	193	Link 1.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			TGCAGCCCCTCGGCATCTACA	0.602		NaN											0	0	0	0.008291	0	11	41									
ZNF99	7652	broad.mit.edu	37	19	22940381	22940381	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:22940381C>T	uc010xrh.1	-	5	2057	c.2057G>A	c.(2056-2058)AGA>AAA	p.R686K		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CTTATGTTTTCTAAGGGCTGA	0.348		NaN											0	0	0	0.008291	0	11	77									
ZNF99	7652	broad.mit.edu	37	19	22940551	22940551	+	Silent	SNP	A	A	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:22940551A>C	uc010xrh.1	-	5	1887	c.1887T>G	c.(1885-1887)CTT>CTG	p.L629L		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CATGTTTTCTAAGAGTTGAGG	0.363		NaN											0	0	0	0.003163	0	15	64									
ZNF91	7644	broad.mit.edu	37	19	23578152	23578152	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:23578152G>A	uc002nre.2	-	1	118	c.5C>T	c.(4-6)CCA>CTA	p.P2L	ZNF91_uc010xrj.1_Missense_Mutation_p.P2L	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	2						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGGGGTTCCTGGCATCTTAGC	0.612		NaN											0	0	0	0.004656	0	21	78									
ZNF507	22847	broad.mit.edu	37	19	32873422	32873422	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:32873422C>A	uc002nte.2	+	6	2682	c.2410C>A	c.(2410-2412)CAT>AAT	p.H804N	ZNF507_uc002ntd.2_Missense_Mutation_p.H804N	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	804	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					TTTGAAGTCTCATATGTGGAA	0.443		NaN											1	0	6.17869e-53	0.00361	7.94403e-53	108	338									
DPY19L3	147991	broad.mit.edu	37	19	32973094	32973094	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:32973094G>C	uc002ntg.2	+	19	2275	c.2099G>C	c.(2098-2100)AGA>ACA	p.R700T	DPY19L3_uc002nth.1_Missense_Mutation_p.R700T|DPY19L3_uc002nti.1_RNA|DPY19L3_uc002ntj.1_Missense_Mutation_p.R122T	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	700						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					TACTTCACCAGAGTGTTCCAG	0.478		NaN											0	0	0	0.00361	0	114	199									
RHPN2	85415	broad.mit.edu	37	19	33490610	33490610	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:33490610C>T	uc002nuf.2	-	10	1173	c.1107G>A	c.(1105-1107)GTG>GTA	p.V369V	RHPN2_uc010xro.1_Silent_p.V218V|RHPN2_uc002nue.2_Silent_p.V99V	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	369	BRO1.				signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)					TGCCTGGCTTCACTGCAAAGA	0.542		NaN											0	0	0	0.002096	0	27	64									
KIAA0355	9710	broad.mit.edu	37	19	34791501	34791501	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:34791501G>A	uc002nvd.3	+	2	982	c.123G>A	c.(121-123)CTG>CTA	p.L41L	KIAA0355_uc010edk.1_Silent_p.L31L	NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	41										ovary(1)	1	Esophageal squamous(110;0.162)					GCCGAGCACTGAGTGCTCCCC	0.637		NaN											0	0	0	0.002299	0	24	65									
SCN1B	6324	broad.mit.edu	37	19	35523533	35523533	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:35523533G>C	uc002nxp.2	+	2	333	c.142G>C	c.(142-144)GAG>CAG	p.E48Q	SCN1B_uc002nxo.1_Missense_Mutation_p.E48Q|SCN1B_uc010xsg.1_Missense_Mutation_p.E48Q	NM_001037	NP_001028	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta	48	Extracellular (Potential).|Ig-like C2-type.				axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GCGCCGCAGCGAGACCAACGC	0.627		NaN											0	0	0	0.00361	0	43	190									
LSR	51599	broad.mit.edu	37	19	35758329	35758329	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:35758329G>A	uc002nyl.2	+	9	1829	c.1606G>A	c.(1606-1608)GAC>AAC	p.D536N	LSR_uc002nym.2_Missense_Mutation_p.D517N|LSR_uc002nyn.2_Missense_Mutation_p.D468N|LSR_uc002nyo.2_Missense_Mutation_p.D516N|LSR_uc010xsr.1_Missense_Mutation_p.D428N|LSR_uc002nyp.2_Missense_Mutation_p.D478N|USF2_uc010xss.1_5'Flank|USF2_uc002nyq.1_5'Flank|USF2_uc002nyr.1_5'Flank|USF2_uc002nys.1_5'Flank|USF2_uc002nyt.1_5'Flank|USF2_uc002nyu.1_5'Flank|USF2_uc002nyv.1_5'Flank	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	536	Cytoplasmic (Potential).				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CGACCTCTATGACCAAGACGA	0.687		NaN											0	0	0	0.004482	0	9	27									
ATP4A	495	broad.mit.edu	37	19	36054367	36054367	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:36054367C>T	uc002oal.1	-	2	104	c.75G>A	c.(73-75)AAG>AAA	p.K25K		NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	25	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	TCTTGCTCATCTTGGCAGCCA	0.577		NaN											0	0	0	0.00361	0	75	280									
MLL4	9757	broad.mit.edu	37	19	36211234	36211234	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:36211234C>T	uc010eei.2	+	3	985	c.985C>T	c.(985-987)CAA>TAA	p.Q329*		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	329					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGGTCAAGGTCAAGGTCAACA	0.512		NaN											0	0	0	0.000602	0	5	26									
TMEM149	79713	broad.mit.edu	37	19	36230880	36230880	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:36230880T>C	uc002obc.2	-	4	553	c.452A>G	c.(451-453)GAG>GGG	p.E151G	TMEM149_uc002obb.2_Intron|TMEM149_uc002obd.3_Missense_Mutation_p.E151G|TMEM149_uc010xsy.1_RNA|TMEM149_uc010eej.2_Missense_Mutation_p.E231G	NM_024660	NP_078936	Q9H665	IGFR1_HUMAN	transmembrane protein 149 precursor	151	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGGGACAGGCTCAGGGGTCCT	0.632		NaN											0	0	0	0.006999	0	40	51									
TMEM149	79713	broad.mit.edu	37	19	36230990	36230990	+	Splice_Site	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:36230990C>T	uc002obc.2	-	4	444	c.343_splice	c.e4-1	p.R115_splice	TMEM149_uc002obb.2_Intron|TMEM149_uc002obd.3_Splice_Site_p.R115_splice|TMEM149_uc010xsy.1_Intron|TMEM149_uc010eej.2_Splice_Site_p.R195_splice	NM_024660	NP_078936	Q9H665	IGFR1_HUMAN	transmembrane protein 149 precursor							integral to membrane|plasma membrane	protein binding|receptor activity				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGACCGGCCTCTGGGGATAAG	0.607		NaN											0	0	0	0.000602	0	4	46									
SPRED3	399473	broad.mit.edu	37	19	38882867	38882867	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:38882867C>T	uc002oim.2	+	3	366	c.362C>T	c.(361-363)TCC>TTC	p.S121F	SPRED3_uc002oil.1_Missense_Mutation_p.S121F	NM_001042522	NP_001035987	Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	121	Ser-rich.				multicellular organismal development					central_nervous_system(2)|lung(1)|skin(1)	4	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTCAccccctcctcctcctcc	0.537		NaN											0	0	0	0.00245	0	15	20									
RYR1	6261	broad.mit.edu	37	19	39017663	39017663	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:39017663C>G	uc002oit.2	+	72	10787	c.10657C>G	c.(10657-10659)CTG>GTG	p.L3553V	RYR1_uc002oiu.2_Missense_Mutation_p.L3548V|RYR1_uc002oiv.1_Missense_Mutation_p.L468V|RYR1_uc010xuf.1_Missense_Mutation_p.L473V	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3553					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCGGGAATTTCTGCACAACAA	0.507		NaN											0	0	0	0.000978	0	11	88									
RYR1	6261	broad.mit.edu	37	19	39034011	39034011	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:39034011A>C	uc002oit.2	+	85	11844	c.11714A>C	c.(11713-11715)CAG>CCG	p.Q3905P	RYR1_uc002oiu.2_Missense_Mutation_p.Q3900P|RYR1_uc002oiv.1_Missense_Mutation_p.Q814P	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3905					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTACGGACACAGACAGGGAAC	0.488		NaN											0	0	0	0.007291	0	28	153									
LRFN1	57622	broad.mit.edu	37	19	39804678	39804678	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:39804678G>C	uc002okw.2	-	1	1299	c.1299C>G	c.(1297-1299)CTC>CTG	p.L433L		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	433	Fibronectin type-III.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			AGTTCGAGGTGAGCTCGGCTG	0.652		NaN											0	0	0	0.00308	0	6	44									
LRFN1	57622	broad.mit.edu	37	19	39804803	39804803	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:39804803G>C	uc002okw.2	-	1	1174	c.1174C>G	c.(1174-1176)CTG>GTG	p.L392V		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	392	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGTGCCATCAGAGGCAGAGGT	0.672		NaN											0	0	0	0.001984	0	7	41									
MED29	55588	broad.mit.edu	37	19	39882056	39882056	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:39882056G>C	uc002olf.2	+	1	94	c.57G>C	c.(55-57)GCG>GCC	p.A19A	PAF1_uc002old.2_5'Flank|PAF1_uc002ole.1_5'Flank|PAF1_uc010xuv.1_5'Flank|MED29_uc010xuw.1_Silent_p.A19A|MED29_uc010xux.1_RNA	NM_017592	NP_060062	Q9NX70	MED29_HUMAN	mediator complex subunit 29	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	protein binding			ovary(1)|pancreas(1)	2	all_cancers(60;7.82e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;1.04e-26)|all cancers(26;7.68e-24)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CGGTCTACGCGAGGAAGATGG	0.617		NaN											0	0	0	0.004482	0	9	33									
PRX	57716	broad.mit.edu	37	19	40902007	40902007	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:40902007G>C	uc002onr.2	-	7	2521	c.2252C>G	c.(2251-2253)TCA>TGA	p.S751*	PRX_uc002onq.2_Nonsense_Mutation_p.S612*|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	751	51.|55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCGAATCTCTGACACTTTCGG	0.592		NaN											0	0	0	0.00361	0	60	236									
SPTBN4	57731	broad.mit.edu	37	19	41029487	41029487	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:41029487G>C	uc002ony.2	+	17	3884	c.3798G>C	c.(3796-3798)CTG>CTC	p.L1266L	SPTBN4_uc002onx.2_Silent_p.L1266L|SPTBN4_uc002onz.2_Silent_p.L1266L|SPTBN4_uc010egx.2_5'UTR	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1266	Spectrin 10.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGGGCCTGCTGAGGCAGGGCA	0.632		NaN											0	0	0	0.00333	0	23	74									
CYP2A7	1549	broad.mit.edu	37	19	41384835	41384835	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:41384835C>G	uc002opm.2	-	5	1203	c.661G>C	c.(661-663)GAG>CAG	p.E221Q	CYP2A7_uc002opo.2_Missense_Mutation_p.E221Q|CYP2A7_uc002opn.2_Missense_Mutation_p.E170Q	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	221						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GAGAACATCTCATAGAGCTGG	0.527		NaN											0	0	0	0.006122	0	15	46									
CIC	23152	broad.mit.edu	37	19	42791575	42791575	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:42791575G>C	uc002otf.1	+	4	596	c.556G>C	c.(556-558)GAG>CAG	p.E186Q		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				CTCATCTTCTGAGAAGGATGG	0.597		NaN	T	DUX4	soft tissue sarcoma								0	0	0	0.00632	0	26	154									
BCL3	602	broad.mit.edu	37	19	45262794	45262794	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:45262794C>T	uc010xxe.1	+	9	1357	c.1287C>T	c.(1285-1287)CCC>CCT	p.P429P		NM_005178	NP_005169	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	429	Pro/Ser-rich.				DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			ovary(1)|lung(1)	2	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				CATCTCCACCCGCCTTCCTGC	0.682		NaN	T	IGH@	CLL 								0	0	0	0.001523	0	19	345									
FOSB	2354	broad.mit.edu	37	19	45976195	45976195	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:45976195C>T	uc002pbx.3	+	4	1534	c.942C>T	c.(940-942)TTC>TTT	p.F314F	ERCC1_uc002pbu.1_Intron|FOSB_uc010eke.2_Silent_p.F239F|FOSB_uc002pby.3_Silent_p.F278F|FOSB_uc010eka.1_3'UTR|FOSB_uc010ekb.1_3'UTR|FOSB_uc010ekc.1_3'UTR|FOSB_uc010ekf.2_Silent_p.F275F|FOSB_uc010ekd.1_3'UTR|FOSB_uc010ekg.2_Silent_p.F171F|FOSB_uc002pca.3_Silent_p.F265F	NM_006732	NP_006723	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B	314					behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|lung(1)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		TCTCCGCGTTCGCCGGCGCCC	0.577		NaN											0	0	0	0.00333	0	25	169									
FBXO46	23403	broad.mit.edu	37	19	46215530	46215530	+	Silent	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:46215530G>T	uc002pcy.2	-	2	1349	c.1224C>A	c.(1222-1224)CTC>CTA	p.L408L	FBXO46_uc002pcz.2_Silent_p.L408L	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	408							protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		GGAGAAAGAAGAGCTGGCCCG	0.701		NaN											1	0	2.52707e-12	0.006214	3.15063e-12	8	62									
NPAS1	4861	broad.mit.edu	37	19	47535945	47535945	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:47535945C>G	uc002pfw.2	+	5	673	c.477C>G	c.(475-477)TTC>TTG	p.F159L	NPAS1_uc002pfx.2_5'UTR|NPAS1_uc002pfy.2_Missense_Mutation_p.F159L|NPAS1_uc010xyj.1_5'Flank	NM_002517	NP_002508	Q99742	NPAS1_HUMAN	neuronal PAS domain protein 1	159	PAS 1.				central nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity				0		all_cancers(25;4.31e-08)|all_epithelial(76;2.96e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.102)		all cancers(93;6.02e-05)|OV - Ovarian serous cystadenocarcinoma(262;7.35e-05)|Epithelial(262;0.00389)|GBM - Glioblastoma multiforme(486;0.0252)		AAGGAAAATTCCTCTACATCT	0.577		NaN									OREG0025585	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005443	0	25	101									
NPAS1	4861	broad.mit.edu	37	19	47535976	47535976	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:47535976C>T	uc002pfw.2	+	5	704	c.508C>T	c.(508-510)CTG>TTG	p.L170L	NPAS1_uc002pfx.2_5'UTR|NPAS1_uc002pfy.2_Silent_p.L170L|NPAS1_uc010xyj.1_5'Flank	NM_002517	NP_002508	Q99742	NPAS1_HUMAN	neuronal PAS domain protein 1	170	PAS 1.				central nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity				0		all_cancers(25;4.31e-08)|all_epithelial(76;2.96e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.102)		all cancers(93;6.02e-05)|OV - Ovarian serous cystadenocarcinoma(262;7.35e-05)|Epithelial(262;0.00389)|GBM - Glioblastoma multiforme(486;0.0252)		CTCCATCTATCTGGGTCTCTC	0.552		NaN									OREG0025585	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001523	0	20	75									
DHX34	9704	broad.mit.edu	37	19	47856631	47856631	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:47856631C>T	uc010xyn.1	+	2	685	c.344C>T	c.(343-345)ACG>ATG	p.T115M	DHX34_uc010elc.1_Missense_Mutation_p.T115M	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	115						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GGCCCTGCCACGCGGGGCTCT	0.642		NaN											0	0	0	0.005443	0	27	161									
NAPA	8775	broad.mit.edu	37	19	47998837	47998837	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:47998837C>G	uc002pha.1	-	4	612	c.312G>C	c.(310-312)TTG>TTC	p.L104F	uc002pgz.1_RNA|NAPA_uc002phb.1_Missense_Mutation_p.L65F|NAPA_uc002phc.1_5'UTR|NAPA_uc002phd.1_Missense_Mutation_p.L104F|NAPA_uc010elf.1_5'UTR	NM_003827	NP_003818	P54920	SNAA_HUMAN	N-ethylmaleimide-sensitive factor attachment	104					cellular membrane fusion|intra-Golgi vesicle-mediated transport|post-Golgi vesicle-mediated transport	cytosol					0		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000466)|all cancers(93;0.000739)|Epithelial(262;0.0168)|GBM - Glioblastoma multiforme(486;0.049)		TTGCTCGCATCAAACAGTTAA	0.567		NaN											0	0	0	0.001523	0	19	216									
CCDC114	93233	broad.mit.edu	37	19	48801464	48801464	+	Silent	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:48801464G>T	uc002pir.2	-	11	1946	c.1263C>A	c.(1261-1263)CTC>CTA	p.L421L	CCDC114_uc002piq.2_Silent_p.L230L|CCDC114_uc002pio.2_Silent_p.L458L|CCDC114_uc002pis.1_Silent_p.L101L|CCDC114_uc002pit.1_Silent_p.L458L	NM_144577	NP_653178	Q96M63	CC114_HUMAN	coiled-coil domain containing 114 isoform 2	421										ovary(1)	1		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		GCACTGTCAGGAGCTCCACCA	0.652		NaN											1	0	3.27435e-08	0.00245	3.98906e-08	15	56									
RASIP1	54922	broad.mit.edu	37	19	49238679	49238679	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:49238679G>A	uc002pki.2	-	4	1150	c.953C>T	c.(952-954)TCA>TTA	p.S318L		NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	318					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		CAAGTTTTCTGAGCGCTCCTT	0.701		NaN											0	0	0	0.004482	0	8	24									
DHDH	27294	broad.mit.edu	37	19	49436972	49436972	+	Translation_Start_Site	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:49436972C>G	uc002ple.1	+	1	34	c.-6C>G	c.(-8--4)ATCGC>ATGGC			NM_014475	NP_055290	Q9UQ10	DHDH_HUMAN	dimeric dihydrodiol dehydrogenase						carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		GGCTCCGCATCGCAACCATGG	0.682		NaN											0	0	0	0.008361	0	25	54									
TRPM4	54795	broad.mit.edu	37	19	49661463	49661463	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:49661463G>T	uc002pmw.2	+	2	111	c.39G>T	c.(37-39)AAG>AAT	p.K13N	TRPM4_uc010emu.2_Missense_Mutation_p.K13N|TRPM4_uc010yak.1_5'UTR|TRPM4_uc002pmx.2_5'UTR|TRPM4_uc010emv.2_Missense_Mutation_p.K13N|TRPM4_uc010yal.1_5'UTR|HRC_uc002pmv.2_5'Flank	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	13	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GGATCCCCAAGATCTTCAAGA	0.602		NaN											1	0	3.19358e-47	0.00361	4.09871e-47	73	333									
TRPM4	54795	broad.mit.edu	37	19	49661514	49661514	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:49661514G>A	uc002pmw.2	+	2	162	c.90G>A	c.(88-90)CCG>CCA	p.P30P	TRPM4_uc010emu.2_Silent_p.P30P|TRPM4_uc010yak.1_5'UTR|TRPM4_uc002pmx.2_5'UTR|TRPM4_uc010emv.2_Silent_p.P30P|TRPM4_uc010yal.1_5'UTR|HRC_uc002pmv.2_5'Flank	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	30	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CCACAGATCCGGGGTGAGGAG	0.627		NaN											0	0	0	0.00361	0	55	317									
FCGRT	2217	broad.mit.edu	37	19	50029338	50029338	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:50029338G>A	uc002poe.2	+	7	1546	c.1060G>A	c.(1060-1062)GAT>AAT	p.D354N	FCGRT_uc002pod.2_RNA|FCGRT_uc002pog.2_Missense_Mutation_p.D354N|FCGRT_uc002poi.2_RNA|RCN3_uc002poj.2_5'Flank	NM_001136019	NP_001129491	P55899	FCGRN_HUMAN	Fc fragment of IgG, receptor, transporter, alpha	354	Cytoplasmic (Potential).				antigen processing and presentation|female pregnancy|immune response	integral to membrane|MHC class I protein complex	IgG binding|receptor activity			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00291)|GBM - Glioblastoma multiforme(134;0.0156)		CCAGGATGCTGATTTGAAGGA	0.577		NaN											0	0	0	0.003755	0	33	311									
SHANK1	50944	broad.mit.edu	37	19	51165245	51165245	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:51165245G>A	uc002psx.1	-	23	6482	c.6463C>T	c.(6463-6465)CTC>TTC	p.L2155F	SHANK1_uc002psw.1_Missense_Mutation_p.L1539F	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2155	SAM.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		AAGAATTTGAGAGCCCGGTCG	0.612		NaN											0	0	0	0.005443	0	26	89									
ACPT	93650	broad.mit.edu	37	19	51293713	51293713	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:51293713C>G	uc002pta.1	+	1	42	c.42C>G	c.(40-42)CTC>CTG	p.L14L		NM_033068	NP_149059	Q9BZG2	PPAT_HUMAN	testicular acid phosphatase precursor	14						integral to membrane	acid phosphatase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CTGGACCTCTCctgctgctgc	0.627		NaN											0	0	0	0.000602	0	4	17									
SIGLEC8	27181	broad.mit.edu	37	19	51958762	51958762	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:51958762T>C	uc002pwt.2	-	4	1028	c.961A>G	c.(961-963)AGG>GGG	p.R321G	SIGLEC8_uc010yda.1_Missense_Mutation_p.R212G|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_Missense_Mutation_p.R228G	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	321	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CCTTCATCCCTCACGTGCACT	0.642		NaN											0	0	0	0.001168	0	6	41									
FPR2	2358	broad.mit.edu	37	19	52272587	52272587	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:52272587G>T	uc002pxr.2	+	2	721	c.676G>T	c.(676-678)GCC>TCC	p.A226S	FPR2_uc002pxs.3_Missense_Mutation_p.A226S|FPR2_uc010epf.2_Missense_Mutation_p.A226S	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	226	Helical; Name=5; (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						GCTCATTGCAGCCAAGATCCA	0.498		NaN											1	0	4.67007e-22	0.00874	5.94597e-22	42	58									
PPP2R1A	5518	broad.mit.edu	37	19	52719275	52719275	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:52719275C>T	uc002pyp.2	+	8	1100	c.941C>T	c.(940-942)TCA>TTA	p.S314L	PPP2R1A_uc010ydk.1_Missense_Mutation_p.S259L|PPP2R1A_uc010epm.1_Missense_Mutation_p.S354L|PPP2R1A_uc002pyq.2_Missense_Mutation_p.S135L	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	314	PP2A subunit B binding.|HEAT 8.|Polyoma small and medium T antigens Binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GAAAACCTCTCAGCTGACTGT	0.547		NaN	Mis		clear cell ovarian carcinoma								0	0	0	0.002222	0	43	51									
ZNF845	91664	broad.mit.edu	37	19	53856074	53856074	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:53856074G>C	uc010ydv.1	+	4	2263	c.2146G>C	c.(2146-2148)GAG>CAG	p.E716Q	ZNF845_uc010ydw.1_Missense_Mutation_p.E716Q	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	716				Missing (in Ref. 1; BAG58121).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCATACTGGAGAGAAACCTTA	0.418		NaN											0	0	0	0.004289	0	37	118									
CACNG6	59285	broad.mit.edu	37	19	54496189	54496189	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:54496189C>T	uc002qct.2	+	1	648	c.58C>T	c.(58-60)CGG>TGG	p.R20W	CACNG6_uc002qcu.2_Missense_Mutation_p.R20W|CACNG6_uc002qcv.2_Missense_Mutation_p.R20W	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	20						voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		ggccgcgggccggcggcgggc	0.572		NaN											0	0	0	0.000248	0	4	31									
TTYH1	57348	broad.mit.edu	37	19	54933464	54933464	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:54933464G>C	uc002qfq.2	+	4	610	c.518G>C	c.(517-519)CGA>CCA	p.R173P	TTYH1_uc010yey.1_Missense_Mutation_p.R222P|TTYH1_uc002qfr.2_Missense_Mutation_p.R173P|TTYH1_uc002qft.2_Missense_Mutation_p.R173P|TTYH1_uc002qfu.1_Missense_Mutation_p.R85P	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	173	Extracellular (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		GCTGCCGCCCGAGGGGCTCGA	0.711		NaN											0	0	0	0.000248	0	4	9									
NCR1	9437	broad.mit.edu	37	19	55420603	55420603	+	Splice_Site	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:55420603G>A	uc002qib.2	+	4	394	c.356_splice	c.e4-1	p.E119_splice	NCR1_uc002qic.2_Splice_Site_p.E119_splice|NCR1_uc002qie.2_Splice_Site_p.E119_splice|NCR1_uc002qid.2_Splice_Site_p.Q24_splice|NCR1_uc002qif.2_Splice_Site_p.Q24_splice|NCR1_uc010esj.2_Splice_Site_p.E12_splice	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1						cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		TTCTCTCATAGAAATGTATGA	0.408		NaN											0	0	0	0.001168	0	5	65									
RDH13	112724	broad.mit.edu	37	19	55570559	55570559	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:55570559G>A	uc002qio.3	-	2	335	c.150C>T	c.(148-150)ATC>ATT	p.I50I	RDH13_uc002qip.2_5'UTR|RDH13_uc010yfq.1_Intron	NM_001145971	NP_001139443	Q8NBN7	RDH13_HUMAN	retinol dehydrogenase 13 isoform 1	50	NAD or NADP (By similarity).						binding|oxidoreductase activity			large_intestine(1)|ovary(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(297;0.199)	GBM - Glioblastoma multiforme(193;0.0504)	Vitamin A(DB00162)	TCTGCTTCCCGATGCCTGTGT	0.483		NaN											0	0	0	0.006214	0	10	8									
ZNF471	57573	broad.mit.edu	37	19	57036421	57036421	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:57036421G>A	uc002qnh.2	+	5	1118	c.985G>A	c.(985-987)GAT>AAT	p.D329N		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	329	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		AGCCTTCAGTGATGGCTCGTC	0.433		NaN											0	0	0	0.003954	0	21	91									
ZNF549	256051	broad.mit.edu	37	19	58049333	58049333	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:58049333G>A	uc002qpb.1	+	4	1210	c.961G>A	c.(961-963)GAA>AAA	p.E321K	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF549_uc002qpa.1_Missense_Mutation_p.E308K	NM_153263	NP_694995	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	321	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTCACTTGTGGAACACCAGAG	0.438		NaN											0	0	0	0.001523	0	21	90									
ZSCAN1	284312	broad.mit.edu	37	19	58551908	58551908	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:58551908C>T	uc002qrc.1	+	4	708	c.461C>T	c.(460-462)TCG>TTG	p.S154L		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	154					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AAAGAACCATCGCAGGTGAGC	0.627		NaN											0	0	0	0.006214	0	9	172									
ZSCAN22	342945	broad.mit.edu	37	19	58850581	58850581	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:58850581G>C	uc002qsc.2	+	3	1512	c.1365G>C	c.(1363-1365)CAG>CAC	p.Q455H	ZSCAN22_uc010yhz.1_3'UTR	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	455	C2H2-type 7.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		TTGAGCACCAGAGGATCCACA	0.542		NaN											0	0	0	0.001855	0	14	116									
ZSCAN22	342945	broad.mit.edu	37	19	58850597	58850597	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:58850597G>C	uc002qsc.2	+	3	1528	c.1381G>C	c.(1381-1383)GAG>CAG	p.E461Q	ZSCAN22_uc010yhz.1_3'UTR	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	461					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		CCACACGGGAGAGAAGCCTTA	0.542		NaN											0	0	0	0.004482	0	8	110									
ZBTB45	84878	broad.mit.edu	37	19	59025544	59025544	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:59025544C>T	uc002qtd.2	-	3	1705	c.1413G>A	c.(1411-1413)AAG>AAA	p.K471K	SLC27A5_uc002qtc.2_5'Flank|ZBTB45_uc002qte.2_Silent_p.K471K|ZBTB45_uc002qtf.2_Silent_p.K471K	NM_032792	NP_116181	Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	471	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		TGAGCGAGCTCTTCTGCGTGA	0.682		NaN											0	0	0	0.001984	0	6	30									
TMEM18	129787	broad.mit.edu	37	2	675513	675513	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:675513G>T	uc002qwl.2	-	2	269	c.175C>A	c.(175-177)CTA>ATA	p.L59I	TMEM18_uc002qwk.2_RNA|uc002qwm.1_5'Flank	NM_152834	NP_690047	Q96B42	TMM18_HUMAN	transmembrane protein 18	59	Helical; (Potential).				cell migration	integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;5.27e-05)|all_epithelial(98;2.11e-06)|Ovarian(717;0.0253)		all cancers(51;1.95e-21)|Epithelial(75;9.47e-21)|OV - Ovarian serous cystadenocarcinoma(76;8.15e-18)|GBM - Glioblastoma multiforme(21;0.0285)		TACTCACCTAGACACAGAAAG	0.483		NaN											1	0	3.86212e-05	0.008291	4.61915e-05	9	113									
SNTG2	54221	broad.mit.edu	37	2	1263181	1263181	+	Missense_Mutation	SNP	C	C	G	rs145354756	by1000genomes	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:1263181C>G	uc002qwq.2	+	13	1173	c.1045C>G	c.(1045-1047)CAC>GAC	p.H349D	SNTG2_uc010ewi.2_Missense_Mutation_p.H222D	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	349	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		AAGGACCTATCACCTCTGTGA	0.413		NaN											0	0	0	0.003755	0	30	64									
COLEC11	78989	broad.mit.edu	37	2	3660949	3660949	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:3660949G>C	uc002qya.2	+	3	327	c.179G>C	c.(178-180)AGA>ACA	p.R60T	COLEC11_uc002qxz.2_Missense_Mutation_p.E31Q|COLEC11_uc002qyb.2_Intron|COLEC11_uc002qyc.2_Missense_Mutation_p.R60T|COLEC11_uc010ewo.2_Intron|COLEC11_uc010ewp.2_Missense_Mutation_p.R34T|COLEC11_uc010ewq.2_Intron|COLEC11_uc010ewr.2_Missense_Mutation_p.R34T|COLEC11_uc010ews.2_Intron	NM_024027	NP_076932	Q9BWP8	COL11_HUMAN	collectin sub-family member 11 isoform a	60						collagen	mannose binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		CGGCCTGGAAGAGTCGGCCCC	0.647		NaN											0	0	0	0.000602	0	4	17									
KLF11	8462	broad.mit.edu	37	2	10187909	10187909	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:10187909C>G	uc002raf.1	+	3	607	c.445C>G	c.(445-447)CTG>GTG	p.L149V	KLF11_uc010yjc.1_Missense_Mutation_p.L132V	NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	149				VVARALS -> QWPDSD (in Ref. 3).	apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		GGCCAGAGCTCTGAGCGGGGG	0.612		NaN											0	0	0	0.00278	0	23	51									
RRM2	6241	broad.mit.edu	37	2	10269373	10269373	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:10269373G>C	uc002rah.2	+	10	1221	c.1030G>C	c.(1030-1032)GAG>CAG	p.E344Q		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	344					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		TTTCAGAGTAGAGAACCCATT	0.378		NaN											0	0	0	0.004482	0	9	53									
GREB1	9687	broad.mit.edu	37	2	11756766	11756766	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:11756766C>G	uc002rbk.1	+	21	3632	c.3332C>G	c.(3331-3333)TCG>TGG	p.S1111W	GREB1_uc002rbp.1_Missense_Mutation_p.S109W	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1111	Ser-rich.					integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GGCTCTACCTCGGAGAAGAGA	0.413		NaN											0	0	0	0.00632	0	27	168									
MYCN	4613	broad.mit.edu	37	2	16082244	16082244	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:16082244G>C	uc002rci.2	+	2	358	c.58G>C	c.(58-60)GAG>CAG	p.E20Q	MYCNOS_uc002rch.1_5'Flank|MYCN_uc010yjr.1_Missense_Mutation_p.E12Q	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	20					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			CCCAGACCTCGAGTTTGACTC	0.642		NaN	A		neuroblastoma								0	0	0	0.000602	0	5	41									
HADHA	3030	broad.mit.edu	37	2	26414459	26414459	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:26414459C>G	uc002rgy.2	-	19	2169	c.2039G>C	c.(2038-2040)AGA>ACA	p.R680T	HADHA_uc010yks.1_Missense_Mutation_p.R593T	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	680					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	ATTCACAAATCTTGTCACCAG	0.542		NaN											0	0	0	0.007835	0	38	61									
HADHB	3032	broad.mit.edu	37	2	26501592	26501592	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:26501592G>C	uc002rgz.2	+	8	804	c.553G>C	c.(553-555)GAT>CAT	p.D185H	HADHB_uc010ykv.1_Missense_Mutation_p.D163H|HADHB_uc010ykw.1_Missense_Mutation_p.D170H|HADHB_uc002rha.2_Intron|HADHB_uc010ykx.1_Missense_Mutation_p.D111H	NM_000183	NP_000174	P55084	ECHB_HUMAN	mitochondrial trifunctional protein, beta	185					fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACTGATGCTTGATCTCAATAA	0.453		NaN											0	0	0	0.000978	0	12	81									
PPP1CB	5500	broad.mit.edu	37	2	29016810	29016810	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:29016810G>C	uc002rmg.2	+	8	986	c.826G>C	c.(826-828)GAT>CAT	p.D276H	PPP1CB_uc010ymj.1_Missense_Mutation_p.D248H|PPP1CB_uc010yml.1_Missense_Mutation_p.D248H|PPP1CB_uc002rmh.2_Missense_Mutation_p.D276H|SPDYA_uc002rmi.2_5'UTR	NM_206876	NP_996759	P62140	PP1B_HUMAN	protein phosphatase 1, catalytic subunit, beta	276					cell cycle|cell division|glycogen metabolic process|triglyceride catabolic process	MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|myosin phosphatase activity|myosin-light-chain-phosphatase activity|protein binding			skin(1)	1	Acute lymphoblastic leukemia(172;0.155)					TGGCGAGTTTGATAATGCTGG	0.348		NaN											0	0	0	0.00333	0	25	53									
ALK	238	broad.mit.edu	37	2	29519819	29519819	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:29519819G>A	uc002rmy.2	-	9	2659	c.1752C>T	c.(1750-1752)GTC>GTT	p.V584V		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	584	MAM 2.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CATAGGCGGCGACATGCCAGA	0.557		NaN	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				0	0	0	0.001368	0	12	38									
BIRC6	57448	broad.mit.edu	37	2	32678919	32678919	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:32678919C>T	uc010ezu.2	+	23	4796	c.4662C>T	c.(4660-4662)TTC>TTT	p.F1554F		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1554					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					AGGGTAGTTTCACATCTCTCA	0.383		NaN											0	0	0	0.00361	0	70	125									
EIF2AK2	5610	broad.mit.edu	37	2	37374019	37374019	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:37374019C>G	uc010ynh.1	-	4	774	c.217G>C	c.(217-219)GAG>CAG	p.E73Q	EIF2AK2_uc010fab.1_Missense_Mutation_p.E73Q|EIF2AK2_uc010yng.1_Missense_Mutation_p.E73Q|EIF2AK2_uc010fac.2_Missense_Mutation_p.E73Q|EIF2AK2_uc010fad.2_Missense_Mutation_p.E73Q	NM_002759	NP_002750	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha	73	DRBM 1.				evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			ovary(2)|lung(2)|pancreas(1)	5		all_hematologic(82;0.248)				TTAAGTATCTCAACAGCTAAT	0.343		NaN											0	0	0	0.003954	0	26	64									
SOS1	6654	broad.mit.edu	37	2	39249913	39249913	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:39249913C>G	uc002rrk.3	-	10	1697	c.1656G>C	c.(1654-1656)AGG>AGC	p.R552S	SOS1_uc010ynr.1_RNA|SOS1_uc002rrj.3_Missense_Mutation_p.R166S|SOS1_uc002rrl.2_Missense_Mutation_p.R284S	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	552			R -> G (in NS4; increases the basal level of active RAS; prolonges RAS activation after EGF stimulation and enhances ERK activation).|R -> S (in NS4).|R -> K (in NS4).		apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				CATCAAGCATCCTTTCCAGTG	0.403		NaN							Noonan_syndrome				0	0	0	0.008361	0	29	83									
SOS1	6654	broad.mit.edu	37	2	39250197	39250197	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:39250197C>T	uc002rrk.3	-	10	1413	c.1372G>A	c.(1372-1374)GAG>AAG	p.E458K	SOS1_uc010ynr.1_RNA|SOS1_uc002rrj.3_Missense_Mutation_p.E72K|SOS1_uc002rrl.2_Missense_Mutation_p.E190K	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	458	PH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				ATGTGTCTCTCATGTTTGGCT	0.388		NaN							Noonan_syndrome				0	0	0	0.004878	0	37	75									
MAP4K3	8491	broad.mit.edu	37	2	39477777	39477777	+	Silent	SNP	A	A	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:39477777A>G	uc002rro.2	-	34	2758	c.2667T>C	c.(2665-2667)GGT>GGC	p.G889G	MAP4K3_uc002rrp.2_Silent_p.G868G|MAP4K3_uc010yns.1_Silent_p.G442G	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	889					JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				TGTTTTCATGACCCGCCAGGA	0.378		NaN											0	0	0	0.00308	0	7	35									
MAP4K3	8491	broad.mit.edu	37	2	39505625	39505625	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:39505625G>A	uc002rro.2	-	24	1808	c.1717C>T	c.(1717-1719)CAG>TAG	p.Q573*	MAP4K3_uc002rrp.2_Nonsense_Mutation_p.Q552*|MAP4K3_uc010yns.1_Nonsense_Mutation_p.Q126*	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	573	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				ATCAAGTACTGATCTGAAATA	0.254		NaN											0	0	0	0.001984	0	6	37									
PLEKHH2	130271	broad.mit.edu	37	2	43937240	43937240	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:43937240C>T	uc010yny.1	+	12	2161	c.2078C>T	c.(2077-2079)TCA>TTA	p.S693L	PLEKHH2_uc002rte.3_Missense_Mutation_p.S693L|PLEKHH2_uc002rtf.3_Missense_Mutation_p.S692L	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	693	Poly-Ser.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AAAACTTGCTCATCTTCCAGT	0.398		NaN											0	0	0	0.008291	0	11	100									
PLEKHH2	130271	broad.mit.edu	37	2	43992600	43992600	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:43992600C>T	uc010yny.1	+	30	4428	c.4345C>T	c.(4345-4347)CAG>TAG	p.Q1449*		NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	1449	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CAACTTCCATCAGCAAAAGGC	0.468		NaN											0	0	0	0.001786	0	27	53									
SIX3	6496	broad.mit.edu	37	2	45169727	45169727	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:45169727C>T	uc002run.1	+	1	691	c.484C>T	c.(484-486)CAC>TAC	p.H162Y		NM_005413	NP_005404	O95343	SIX3_HUMAN	SIX homeobox 3	162					visual perception	nucleus					0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CAAGGAGTCTCACGGCAAGCT	0.662		NaN											0	0	0	0.001984	0	6	21									
GPR75	10936	broad.mit.edu	37	2	54080974	54080974	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:54080974G>A	uc002rxo.3	-	2	1191	c.920C>T	c.(919-921)TCA>TTA	p.S307L	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	307	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GTTGATGGCTGATACGAGCTG	0.532		NaN											0	0	0	0.008291	0	11	41									
RAB11FIP5	26056	broad.mit.edu	37	2	73339501	73339501	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:73339501G>A	uc002siu.3	-	1	646	c.405C>T	c.(403-405)TTC>TTT	p.F135F		NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	135					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						GGCCTGCGCCGAAGACCTCGT	0.711		NaN											0	0	0	0.008871	0	17	22									
RAB11FIP5	26056	broad.mit.edu	37	2	73339600	73339600	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:73339600G>A	uc002siu.3	-	1	547	c.306C>T	c.(304-306)TCC>TCT	p.S102S		NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	102	C2.				protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						AGGCGGCGGCGGAGCTCGCGG	0.751		NaN											0	0	0	0.001984	0	6	14									
NAT8B	51471	broad.mit.edu	37	2	73928087	73928087	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:73928087C>G	uc002sjk.1	-	2	381	c.346G>C	c.(346-348)GAG>CAG	p.E116Q		NM_016347	NP_057431	Q9UHF3	NAT8B_HUMAN	N-acetyltransferase 8B	116	N-acetyltransferase.				gastrulation with mouth forming second	integral to membrane	N-acetyltransferase activity				0						ACCACCTTCTCTTCAGATTCA	0.537		NaN											0	0	0	0.003163	0	14	68									
BOLA3	388962	broad.mit.edu	37	2	74372361	74372361	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:74372361C>G	uc002skc.1	-	2	162	c.124G>C	c.(124-126)GAA>CAA	p.E42Q	BOLA3_uc002skd.1_Missense_Mutation_p.E42Q|uc002ske.2_5'Flank|uc002skf.2_5'Flank|uc002skg.2_5'Flank	NM_212552	NP_997717	Q53S33	BOLA3_HUMAN	bolA-like 3 isoform 1	42						extracellular region					0						GGAAACTTTTCTTTGAGAATT	0.478		NaN											0	0	0	0.006214	0	10	74									
DCTN1	1639	broad.mit.edu	37	2	74598163	74598163	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:74598163C>G	uc002skx.2	-	9	1097	c.786G>C	c.(784-786)AAG>AAC	p.K262N	DCTN1_uc002skv.2_Missense_Mutation_p.K128N|DCTN1_uc002sku.2_Missense_Mutation_p.K128N|DCTN1_uc002skw.1_Missense_Mutation_p.K238N|DCTN1_uc010ffd.2_Missense_Mutation_p.K242N|DCTN1_uc002sky.2_Missense_Mutation_p.K225N	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	262	Potential.				cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						GCATTTTGCTCTTCCATTCCT	0.552		NaN											0	0	0	0.00361	0	59	373									
LOXL3	84695	broad.mit.edu	37	2	74762786	74762786	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:74762786C>T	uc002smp.1	-	8	1417	c.1345G>A	c.(1345-1347)GAC>AAC	p.D449N	LOXL3_uc002smo.1_Missense_Mutation_p.D88N|LOXL3_uc010ffm.1_Intron|LOXL3_uc002smq.1_Missense_Mutation_p.D304N|LOXL3_uc010ffn.1_Missense_Mutation_p.D304N	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	449	SRCR 4.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						GTCCCCCAGTCATCCCCACAG	0.662		NaN											0	0	0	0.00333	0	23	114									
C2orf3	6936	broad.mit.edu	37	2	75915007	75915007	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:75915007C>G	uc002sno.2	-	11	1766	c.1636G>C	c.(1636-1638)GAT>CAT	p.D546H	C2orf3_uc010ffs.2_Missense_Mutation_p.D108H|C2orf3_uc002snn.2_Missense_Mutation_p.D377H|C2orf3_uc010fft.2_Missense_Mutation_p.D221H	NM_003203	NP_003194	P16383	GCF_HUMAN	hypothetical protein LOC6936	546					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						ACTTTTTTATCTGAACTACTT	0.348		NaN											0	0	0	0.004482	0	8	55									
KCMF1	56888	broad.mit.edu	37	2	85262250	85262250	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:85262250C>G	uc002sox.3	+	3	640	c.296C>G	c.(295-297)TCT>TGT	p.S99C		NM_020122	NP_064507	Q9P0J7	KCMF1_HUMAN	potassium channel modulatory factor 1	99	C2H2-type.					intracellular	ligase activity|zinc ion binding			ovary(2)	2						CATGTTACTTCTGAACATGCA	0.378		NaN											0	0	0	0.00499	0	16	24									
VAMP5	10791	broad.mit.edu	37	2	85820206	85820206	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:85820206C>T	uc002spu.1	+	3	360	c.277C>T	c.(277-279)CTC>TTC	p.L93F	RNF181_uc002spv.1_5'Flank	NM_006634	NP_006625	O95183	VAMP5_HUMAN	vesicle-associated membrane protein 5	93	Helical; Anchor for type IV membrane protein; (Potential).				cell differentiation|vesicle-mediated transport	endomembrane system					0						GGTCGTCTTTCTCCCTCAGAG	0.592		NaN											0	0	0	0.003163	0	15	65									
SEMA4C	54910	broad.mit.edu	37	2	97529515	97529515	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:97529515G>C	uc002sxh.3	-	12	1507	c.1347C>G	c.(1345-1347)CTC>CTG	p.L449L	SEMA4C_uc002sxf.3_5'Flank|SEMA4C_uc002sxe.2_5'Flank|SEMA4C_uc002sxg.3_Silent_p.L502L	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	449	Extracellular (Potential).|Dominant negative effect on myogenic differentiation (By similarity).|Sema.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						TCACAGCCTTGAGCAGCCAGC	0.617		NaN											0	0	0	0.000602	0	4	49									
TMEM131	23505	broad.mit.edu	37	2	98377308	98377308	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:98377308C>G	uc002syh.3	-	37	5188	c.4959G>C	c.(4957-4959)AAG>AAC	p.K1653N	TMEM131_uc002syg.2_Missense_Mutation_p.K33N	NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1653						integral to membrane				ovary(4)|central_nervous_system(2)	6						GGTTGCCGTTCTTGCCCGGGA	0.537		NaN											0	0	0	0.003163	0	15	69									
GPR45	11250	broad.mit.edu	37	2	105859262	105859262	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:105859262A>C	uc002tco.1	+	1	1063	c.947A>C	c.(946-948)AAG>ACG	p.K316T		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	316	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						AGTTACCTCAAGTCCGTCTTC	0.547		NaN											0	0	0	0.007413	0	19	127									
CBWD2	150472	broad.mit.edu	37	2	114220043	114220043	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:114220043G>A	uc002tju.2	+	8	812	c.634G>A	c.(634-636)GAT>AAT	p.D212N	CBWD2_uc010yxw.1_Missense_Mutation_p.D176N|CBWD2_uc002tjv.2_Missense_Mutation_p.D176N|CBWD2_uc010fkv.2_RNA	NM_172003	NP_742000	Q8IUF1	CBWD2_HUMAN	COBW domain-containing protein 2	212							ATP binding|protein binding				0						TCCAGAAGAAGATGTAAAGAA	0.323		NaN											0	0	0	0.002852	0	40	95									
STEAP3	55240	broad.mit.edu	37	2	120003084	120003084	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:120003084G>C	uc002tlp.2	+	3	169	c.12G>C	c.(10-12)GAG>GAC	p.E4D	STEAP3_uc002tlq.2_Missense_Mutation_p.E14D|STEAP3_uc002tlr.2_Missense_Mutation_p.E4D|STEAP3_uc010fle.2_Missense_Mutation_p.E4D	NM_018234	NP_060704	Q658P3	STEA3_HUMAN	dudulin 2 isoform b	4	Cytoplasmic (Potential).				apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			central_nervous_system(2)|skin(1)	3						TGCCAGAAGAGATGGACAAGC	0.587		NaN											0	0	0	0.001168	0	5	55									
MYO7B	4648	broad.mit.edu	37	2	128388376	128388376	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:128388376G>C	uc002top.2	+	35	4805	c.4752G>C	c.(4750-4752)GAG>GAC	p.E1584D	MYO7B_uc002tor.1_Missense_Mutation_p.E437D	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1584						apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TGTCACCAGAGAAGAGGAAGC	0.637		NaN											0	0	0	0.000602	0	5	45									
MCM6	4175	broad.mit.edu	37	2	136626327	136626327	+	Silent	SNP	G	G	A	rs34276971		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:136626327G>A	uc002tuw.2	-	4	545	c.469C>T	c.(469-471)CTG>TTG	p.L157L		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	157					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	TCCAAGCACAGAAAAGTTCCG	0.517		NaN											0	0	0	0.00623	0	41	99									
CXCR4	7852	broad.mit.edu	37	2	136872950	136872950	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:136872950C>T	uc002tuz.2	-	2	643	c.548G>A	c.(547-549)AGA>AAA	p.R183K	CXCR4_uc002tuy.2_Missense_Mutation_p.R187K|CXCR4_uc010fnk.2_Missense_Mutation_p.R168K	NM_003467	NP_003458	P61073	CXCR4_HUMAN	chemokine (C-X-C motif) receptor 4 isoform b	183	Extracellular.			R->A: Reduced coreceptor activity for several HIV-1 isolates.	activation of MAPK activity|apoptosis|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|inflammatory response|initiation of viral infection|regulation of chemotaxis|response to hypoxia|response to virus	cell leading edge|cell surface|cytoplasmic membrane-bounded vesicle|integral to membrane|plasma membrane	actin binding|C-X-C chemokine receptor activity|coreceptor activity|myosin light chain binding|ubiquitin binding|ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.155)	Framycetin(DB00452)	ACAGATATATCTGTCATCTGC	0.507		NaN											0	0	0	0.001368	0	13	84									
THSD7B	80731	broad.mit.edu	37	2	137852590	137852590	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:137852590G>A	uc002tva.1	+	3	1005	c.1005G>A	c.(1003-1005)CGG>CGA	p.R335R	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Silent_p.R225R	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GCAGGAGCCGGAACGTGAAGC	0.537		NaN											0	0	0	0.00308	0	7	47									
LRP1B	53353	broad.mit.edu	37	2	141762977	141762977	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:141762977C>G	uc002tvj.1	-	15	3402	c.2430G>C	c.(2428-2430)TTG>TTC	p.L810F	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	810	Extracellular (Potential).|EGF-like 3.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGGGATAGCCAAGCAAAGTG	0.433		NaN								TSP Lung(27;0.18)			0	0	0	0.006214	0	9	72									
ARHGAP15	55843	broad.mit.edu	37	2	144194515	144194515	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:144194515G>C	uc002tvm.3	+	8	758	c.607G>C	c.(607-609)GAA>CAA	p.E203Q	ARHGAP15_uc010zbl.1_Missense_Mutation_p.E203Q|ARHGAP15_uc002tvn.2_5'UTR	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	203					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		AAGAAACCTGGAATTATTCAA	0.338		NaN											0	0	0	0.001368	0	11	38									
ARHGAP15	55843	broad.mit.edu	37	2	144194548	144194548	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:144194548G>A	uc002tvm.3	+	8	791	c.640G>A	c.(640-642)GAA>AAA	p.E214K	ARHGAP15_uc010zbl.1_Missense_Mutation_p.E214K|ARHGAP15_uc002tvn.2_5'UTR	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	214					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		CTCTAGCACTGAATTGCTAAG	0.333		NaN											0	0	0	0.001984	0	6	39									
STAM2	10254	broad.mit.edu	37	2	153006744	153006744	+	Splice_Site	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:153006744C>T	uc002tyc.3	-	2	391	c.41_splice	c.e2-1	p.E14_splice	STAM2_uc010foa.1_Splice_Site_p.E14_splice|STAM2_uc002tyd.2_Splice_Site_p.E14_splice	NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2						cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)		GTGGCTTTTTCTATAAAATAT	0.353		NaN											0	0	0	0.000602	0	4	29									
BAZ2B	29994	broad.mit.edu	37	2	160182266	160182266	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:160182266C>A	uc002uao.2	-	35	6459	c.6107G>T	c.(6106-6108)AGA>ATA	p.R2036I	BAZ2B_uc002uap.2_Missense_Mutation_p.R2000I	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	2036					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CTCCATTTTTCTTTTCTTGAG	0.353		NaN											1	0	2.40579e-17	0.00623	3.03889e-17	39	84									
GRB14	2888	broad.mit.edu	37	2	165349549	165349549	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:165349549G>C	uc002ucl.2	-	14	2161	c.1620C>G	c.(1618-1620)CTC>CTG	p.L540L	GRB14_uc010zcv.1_Silent_p.L453L|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	540					blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						GGCTTGTCTAGAGAGCAATCC	0.353		NaN											0	0	0	0.006122	0	18	47									
SCN2A	6326	broad.mit.edu	37	2	166198839	166198839	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:166198839C>T	uc002udc.2	+	15	2712	c.2422C>T	c.(2422-2424)CTC>TTC	p.L808F	SCN2A_uc002udd.2_Missense_Mutation_p.L808F|SCN2A_uc002ude.2_Missense_Mutation_p.L808F	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	808	II.|Helical; Name=S2 of repeat II; (Potential).				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AGAAATGTTTCTCAAGATAAT	0.343		NaN											0	0	0	0.004656	0	24	51									
SCN2A	6326	broad.mit.edu	37	2	166231393	166231393	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:166231393G>C	uc002udc.2	+	22	4461	c.4171G>C	c.(4171-4173)GAG>CAG	p.E1391Q	SCN2A_uc002udd.2_Missense_Mutation_p.E1391Q|SCN2A_uc002ude.2_Missense_Mutation_p.E1391Q	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1391	III.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AGCTCTCATTGAGAGCAATCA	0.378		NaN											0	0	0	0.002299	0	22	35									
SCN1A	6323	broad.mit.edu	37	2	166898905	166898905	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:166898905C>G	uc010zcz.1	-	12	2058	c.2040G>C	c.(2038-2040)AAG>AAC	p.K680N	SCN1A_uc002udo.3_Missense_Mutation_p.K560N|SCN1A_uc010fpk.2_Missense_Mutation_p.K532N	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	691						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TTGACCTTCTCTTTCTCATTT	0.368		NaN											0	0	0	0.00632	0	29	45									
ITGA6	3655	broad.mit.edu	37	2	173355768	173355768	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:173355768G>A	uc002uhp.1	+	21	2899	c.2696G>A	c.(2695-2697)AGA>AAA	p.R899K	ITGA6_uc010zdy.1_Missense_Mutation_p.R780K|ITGA6_uc002uho.1_Missense_Mutation_p.R899K|ITGA6_uc010fqm.1_Missense_Mutation_p.R530K	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	integrin alpha chain, alpha 6 isoform a	938	Extracellular (Potential).				blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			CACAACTCAAGAAAGAAACGG	0.308		NaN											0	0	0	0.003755	0	35	191									
CIR1	9541	broad.mit.edu	37	2	175213338	175213338	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:175213338C>T	uc002uim.2	-	10	1333	c.1240G>A	c.(1240-1242)GAG>AAG	p.E414K	CIR1_uc002uin.2_Missense_Mutation_p.E288K|CIR1_uc002uio.2_Missense_Mutation_p.E241K|CIR1_uc002uip.2_Missense_Mutation_p.E303K	NM_004882	NP_004873	Q86X95	CIR1_HUMAN	CBF1 interacting corepressor	414	Arg/Ser-rich (RS domain).				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			large_intestine(1)	1						CTGCTTTGCTCTTCACCAGGA	0.507		NaN											0	0	0	0.007835	0	43	251									
WIPF1	7456	broad.mit.edu	37	2	175436406	175436406	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:175436406G>C	uc002uiy.2	-	6	1459	c.1127C>G	c.(1126-1128)TCA>TGA	p.S376*	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Nonsense_Mutation_p.S376*|WIPF1_uc010fqt.1_Nonsense_Mutation_p.S376*|WIPF1_uc002ujc.1_Nonsense_Mutation_p.S376*|WIPF1_uc002uiz.2_Nonsense_Mutation_p.S376*|WIPF1_uc002ujb.1_Nonsense_Mutation_p.S376*|WIPF1_uc010zep.1_Nonsense_Mutation_p.S376*	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	376	XRSGPXPPXP motif 2.|Pro-rich.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						TGTCATACCTGATCGGCCTGG	0.562		NaN											0	0	0	0.003954	0	22	135									
TTC30B	150737	broad.mit.edu	37	2	178417039	178417039	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:178417039C>G	uc002uln.2	-	1	486	c.453G>C	c.(451-453)GAG>GAC	p.E151D	TTC30B_uc010zfc.1_5'UTR	NM_152517	NP_689730	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	151					cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			CGGTCTCATTCTCGCCCCCAC	0.582		NaN											0	0	0	0.00361	0	51	327									
TTN	7273	broad.mit.edu	37	2	179455083	179455083	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:179455083C>T	uc010zfg.1	-	253	53889	c.53665G>A	c.(53665-53667)GAG>AAG	p.E17889K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E11584K|TTN_uc010zfi.1_Missense_Mutation_p.E11517K|TTN_uc010zfj.1_Missense_Mutation_p.E11392K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18816							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTCTTGGCTCACCCTCTCCT	0.408		NaN											0	0	0	0.001855	0	14	103									
TTN	7273	broad.mit.edu	37	2	179611886	179611886	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:179611886G>C	uc002unb.2	-	46	15465	c.15241C>G	c.(15241-15243)CTA>GTA	p.L5081V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	1188							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCTCTCTAGAGTCTCTCCT	0.552		NaN											0	0	0	0.008361	0	30	69									
DNAH7	56171	broad.mit.edu	37	2	196718190	196718190	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:196718190C>T	uc002utj.3	-	46	8759	c.8658G>A	c.(8656-8658)GAG>GAA	p.E2886E		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2886					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATCGAGTTTTCTCACCTCCAA	0.463		NaN											0	0	0	0.004482	0	9	54									
STK17B	9262	broad.mit.edu	37	2	197010766	197010766	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:197010766C>T	uc002utk.2	-	4	673	c.349G>A	c.(349-351)GAA>AAA	p.E117K	STK17B_uc010fsh.2_Missense_Mutation_p.E117K	NM_004226	NP_004217	O94768	ST17B_HUMAN	serine/threonine kinase 17B	117	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			lung(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.141)			CTGAAAATTTCTCCACCTGCA	0.313		NaN											0	0	0	0.001168	0	6	9									
SATB2	23314	broad.mit.edu	37	2	200213701	200213701	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:200213701G>C	uc002uuy.1	-	7	1713	c.896C>G	c.(895-897)TCT>TGT	p.S299C	SATB2_uc010fsq.1_Missense_Mutation_p.S181C|SATB2_uc002uuz.1_Missense_Mutation_p.S299C|SATB2_uc002uva.1_Missense_Mutation_p.S299C|SATB2_uc002uvb.1_Missense_Mutation_p.S42C	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	299						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						AAGCTGGGGAGAAAGAAGACC	0.507		NaN											0	0	0	0.00333	0	23	124									
C2orf60	129450	broad.mit.edu	37	2	200803731	200803731	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:200803731G>C	uc002uvi.3	-	5	677	c.411C>G	c.(409-411)TTC>TTG	p.F137L	C2orf60_uc002uvj.3_5'UTR|C2orf60_uc002uvk.3_RNA|C2orf60_uc010fss.2_5'UTR	NM_001039693	NP_001034782	A2RUC4	TYW5_HUMAN	hypothetical protein LOC129450	137	JmjC.				wybutosine biosynthetic process		iron ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein homodimerization activity|tRNA binding				0						CCTCTTTGAAGAATTCTGGAA	0.308		NaN											0	0	0	0.000602	0	5	36									
ALS2CR8	79800	broad.mit.edu	37	2	203839184	203839184	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:203839184G>A	uc002uzo.2	+	12	1739	c.1459G>A	c.(1459-1461)GAT>AAT	p.D487N	ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Missense_Mutation_p.D411N|ALS2CR8_uc010zib.1_Missense_Mutation_p.D411N|ALS2CR8_uc010zic.1_Missense_Mutation_p.D399N|ALS2CR8_uc002uzp.2_Missense_Mutation_p.D487N	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	487										large_intestine(1)|ovary(1)	2						GAGAAATGGAGATACGGTATA	0.323		NaN											0	0	0	0.004007	0	15	37									
ALS2CR8	79800	broad.mit.edu	37	2	203842024	203842024	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:203842024C>G	uc002uzo.2	+	13	1807	c.1527C>G	c.(1525-1527)CTC>CTG	p.L509L	ALS2CR8_uc010zia.1_Silent_p.L433L|ALS2CR8_uc010zib.1_Silent_p.L433L|ALS2CR8_uc010zic.1_Silent_p.L421L|ALS2CR8_uc002uzp.2_Silent_p.L509L	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	509										large_intestine(1)|ovary(1)	2						GGAATATTCTCAAAGAGACCA	0.269		NaN											0	0	0	0.005443	0	26	118									
DYTN	391475	broad.mit.edu	37	2	207530676	207530676	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:207530676C>A	uc002vbr.1	-	10	1175	c.1058G>T	c.(1057-1059)CGA>CTA	p.R353L		NM_001093730	NP_001087199	A2CJ06	DYTN_HUMAN	dystrotelin	353						plasma membrane	zinc ion binding			ovary(1)|central_nervous_system(1)	2				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TGTTTCAAATCGACAAATTCT	0.393		NaN											1	0	3.32936e-07	0.006122	4.03219e-07	17	80									
MDH1B	130752	broad.mit.edu	37	2	207615685	207615685	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:207615685C>T	uc002vbs.2	-	6	1080	c.1025G>A	c.(1024-1026)CGC>CAC	p.R342H	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Missense_Mutation_p.R342H|MDH1B_uc010fuj.2_Missense_Mutation_p.R244H|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	342					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		TAAAACAGGGCGTGAATAATG	0.328		NaN											0	0	0	0.000978	0	12	46									
C2orf67	151050	broad.mit.edu	37	2	210993855	210993855	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:210993855C>G	uc002vds.2	-	3	1338	c.1130G>C	c.(1129-1131)CGA>CCA	p.R377P	C2orf67_uc002vdt.2_Missense_Mutation_p.R377P|C2orf67_uc002vdw.2_Missense_Mutation_p.R377P|C2orf67_uc002vdv.2_Missense_Mutation_p.R377P|C2orf67_uc002vdx.1_Missense_Mutation_p.R377P	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	377										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		GCTGCCAACTCGTGCTCTGTC	0.433		NaN											0	0	0	0.001855	0	14	114									
IKZF2	22807	broad.mit.edu	37	2	213872434	213872434	+	Missense_Mutation	SNP	C	C	G	rs76325907		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:213872434C>G	uc002vem.2	-	8	1400	c.1231G>C	c.(1231-1233)GAA>CAA	p.E411Q	IKZF2_uc010fuu.2_Missense_Mutation_p.E266Q|IKZF2_uc002vej.2_Missense_Mutation_p.E358Q|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Missense_Mutation_p.E337Q|IKZF2_uc002vel.2_Missense_Mutation_p.E332Q|IKZF2_uc010fuw.2_Missense_Mutation_p.E185Q|IKZF2_uc010fux.2_Missense_Mutation_p.E185Q|IKZF2_uc010fuy.2_Missense_Mutation_p.E339Q|IKZF2_uc002ven.2_Missense_Mutation_p.E385Q|IKZF2_uc002vei.2_Missense_Mutation_p.E189Q	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	411					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		TGGCTGCTTTCTGAGTCAGTG	0.507		NaN											0	0	0	0.00361	0	86	171									
ATIC	471	broad.mit.edu	37	2	216213870	216213870	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:216213870C>T	uc002vex.3	+	15	1731	c.1557C>T	c.(1555-1557)CTC>CTT	p.L519L	ATIC_uc010zjo.1_Silent_p.L460L|ATIC_uc002vey.3_Silent_p.L518L	NM_004044	NP_004035	P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide	519					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	CTGAGTTACTCACTGAGGCAG	0.448		NaN	T	ALK	ALCL								0	0	0	0.003755	0	34	87									
FN1	2335	broad.mit.edu	37	2	216273063	216273063	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:216273063C>A	uc002vfa.2	-	16	2652	c.2386G>T	c.(2386-2388)GAT>TAT	p.D796Y	FN1_uc002vfb.2_Missense_Mutation_p.D796Y|FN1_uc002vfc.2_Missense_Mutation_p.D796Y|FN1_uc002vfd.2_Missense_Mutation_p.D796Y|FN1_uc002vfe.2_Missense_Mutation_p.D796Y|FN1_uc002vff.2_Missense_Mutation_p.D796Y|FN1_uc002vfg.2_Missense_Mutation_p.D796Y|FN1_uc002vfh.2_Missense_Mutation_p.D796Y|FN1_uc002vfi.2_Missense_Mutation_p.D796Y|FN1_uc002vfj.2_Missense_Mutation_p.D796Y	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	796	Fibronectin type-III 2.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGCTCCCCATCCTCAGATATC	0.408		NaN											1	0	1.22574e-08	0.002299	1.49836e-08	24	67									
RNF25	64320	broad.mit.edu	37	2	219532976	219532976	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:219532976G>A	uc002vit.2	-	3	293	c.205C>T	c.(205-207)CAG>TAG	p.Q69*	RNF25_uc010fvw.2_5'UTR	NM_022453	NP_071898	Q96BH1	RNF25_HUMAN	ring finger protein 25	69	RWD.				positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTGGGACCTGAAGCACCAGA	0.547		NaN											0	0	0	0.00333	0	26	56									
TTLL4	9654	broad.mit.edu	37	2	219603658	219603658	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:219603658G>A	uc002viy.2	+	3	1629	c.1259G>A	c.(1258-1260)AGC>AAC	p.S420N	TTLL4_uc010zkl.1_Missense_Mutation_p.S255N|TTLL4_uc010fvx.2_Missense_Mutation_p.S420N	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	420					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		AAGCGTATCAGCATTCACCTC	0.532		NaN											0	0	0	0.007291	0	29	95									
WNT6	7475	broad.mit.edu	37	2	219738481	219738481	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:219738481G>C	uc002vjc.1	+	4	1227	c.1012G>C	c.(1012-1014)GAG>CAG	p.E338Q		NM_006522	NP_006513	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family,	338					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			ovary(2)|skin(1)	3		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCAGCTCGAAGAGAACTGCCT	0.711		NaN											0	0	0	0.004672	0	3	14									
IHH	3549	broad.mit.edu	37	2	219920403	219920403	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:219920403C>T	uc002vjo.1	-	3	762	c.762G>A	c.(760-762)CTG>CTA	p.L254L		NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	254					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAAGGCTCTCAGCCTGTGAG	0.652		NaN											0	0	0	0.007413	0	20	25									
PAX3	5077	broad.mit.edu	37	2	223065952	223065952	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:223065952G>C	uc002vmt.1	-	10	1825	c.1459C>G	c.(1459-1461)CAA>GAA	p.Q487E	PAX3_uc002vmy.1_3'UTR|PAX3_uc002vmv.1_3'UTR|PAX3_uc002vmw.1_Missense_Mutation_p.F404L|PAX3_uc002vmx.1_3'UTR	NM_181459	NP_852124	P23760	PAX3_HUMAN	paired box 3 isoform PAX3e	Error:Variant_position_missing_in_P23760_after_alignment					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAAAGGATTTGAAACCAACTA	0.408		NaN	T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						0	0	0	0.000978	0	10	43									
DOCK10	55619	broad.mit.edu	37	2	225642870	225642870	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:225642870G>C	uc010fwz.1	-	51	6026	c.5787C>G	c.(5785-5787)ATC>ATG	p.I1929M	DOCK10_uc002vob.2_Missense_Mutation_p.I1923M|DOCK10_uc002voa.2_Missense_Mutation_p.I585M	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1929	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TGGAATCCTGGATTATCTTCA	0.353		NaN											0	0	0	0.004482	0	8	30									
COL4A3	1285	broad.mit.edu	37	2	228174028	228174028	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:228174028C>T	uc002vom.1	+	50	4911	c.4749C>T	c.(4747-4749)TTC>TTT	p.F1583F	COL4A3_uc002von.1_Silent_p.F1583F|COL4A3_uc002voo.1_Intron|COL4A3_uc002vop.1_Intron|uc002voq.1_Intron|uc002vor.1_Intron|COL4A3_uc010fxf.1_5'UTR	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1583	Collagen IV NC1.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GATTTTCATTCATCATGGTGA	0.473		NaN											0	0	0	0.001168	0	5	22									
SPHKAP	80309	broad.mit.edu	37	2	228883230	228883230	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:228883230C>T	uc002vpq.2	-	7	2387	c.2340G>A	c.(2338-2340)ACG>ACA	p.T780T	SPHKAP_uc002vpp.2_Silent_p.T780T|SPHKAP_uc010zlx.1_Silent_p.T780T	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	780						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TGACAAGACTCGTGTTGTGTG	0.502		NaN											0	0	0	0.00361	0	46	124									
GPR55	9290	broad.mit.edu	37	2	231775629	231775629	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:231775629C>T	uc002vrg.2	-	2	242	c.49G>A	c.(49-51)GAG>AAG	p.E17K	GPR55_uc002vrf.2_RNA|GPR55_uc010fxs.1_Missense_Mutation_p.E17K	NM_005683	NP_005674	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	17	Extracellular (Potential).				activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		TTCATCAGCTCGTTGACACCG	0.527		NaN											0	0	0	0.004007	0	17	75									
DGKD	8527	broad.mit.edu	37	2	234343105	234343105	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:234343105C>T	uc002vui.1	+	4	440	c.428C>T	c.(427-429)ACT>ATT	p.T143I	DGKD_uc002vuj.1_Missense_Mutation_p.T99I|DGKD_uc010fyh.1_Missense_Mutation_p.T10I|DGKD_uc002vuk.1_Missense_Mutation_p.T10I	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	143	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	GCATTAAAGACTGTGCAGAAC	0.443		NaN											0	0	0	0.00245	0	15	93									
GPC1	2817	broad.mit.edu	37	2	241404929	241404929	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:241404929G>C	uc002vyw.3	+	8	1529	c.1308G>C	c.(1306-1308)CAG>CAC	p.Q436H		NM_002081	NP_002072	P35052	GPC1_HUMAN	glypican 1 precursor	436					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)		TGGCCAACCAGATCAACAACC	0.627		NaN											0	0	0	0.000248	0	4	42									
SEPT2	4735	broad.mit.edu	37	2	242285646	242285646	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:242285646G>C	uc002wbc.2	+	11	1329	c.908G>C	c.(907-909)AGA>ACA	p.R303T	SEPT2_uc002wbd.2_Missense_Mutation_p.R303T|SEPT2_uc002wbf.2_Missense_Mutation_p.R303T|SEPT2_uc002wbg.2_Missense_Mutation_p.R303T|SEPT2_uc002wbh.2_Missense_Mutation_p.R313T|SEPT2_uc010zop.1_Missense_Mutation_p.R338T	NM_001008491	NP_001008491	Q15019	SEPT2_HUMAN	septin 2	303					cell division|mitosis	actin cytoskeleton|cleavage furrow|condensed chromosome kinetochore|midbody|nucleolus|septin complex|spindle	GTP binding			central_nervous_system(1)	1		all_cancers(19;7.62e-41)|all_epithelial(40;1.71e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.24e-34)|all cancers(36;7.15e-32)|OV - Ovarian serous cystadenocarcinoma(60;1.21e-15)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;3.16e-06)|Lung(119;7.81e-05)|LUSC - Lung squamous cell carcinoma(224;0.000742)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0889)		CGTTCTGAGAGACTCAAGAGA	0.517		NaN											0	0	0	0.008291	0	11	24									
PDCD1	5133	broad.mit.edu	37	2	242794494	242794494	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:242794494C>T	uc002wcq.3	-	3	516	c.448G>A	c.(448-450)GAA>AAA	p.E150K	PDCD1_uc010fzs.2_Intron|PDCD1_uc010fzt.2_RNA	NM_005018	NP_005009	Q15116	PDCD1_HUMAN	programmed cell death 1 precursor	150	Extracellular (Potential).				apoptosis|humoral immune response|multicellular organismal development|T cell costimulation	integral to membrane	protein tyrosine phosphatase activity|signal transducer activity			ovary(1)	1		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0219)		GTGGGCACTTCTGCCCTTCTC	0.677		NaN											0	0	0	0.00499	0	15	25									
ANGPT4	51378	broad.mit.edu	37	20	854974	854974	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:854974G>C	uc002wei.2	-	8	1407	c.1304C>G	c.(1303-1305)TCA>TGA	p.S435*	ANGPT4_uc010zpn.1_Intron	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	435	Fibrinogen C-terminal.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						GTCGTTGTCTGAGTCAAGGGT	0.612		NaN											0	0	0	0.005443	0	26	90									
NSFL1C	55968	broad.mit.edu	37	20	1447415	1447415	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:1447415C>A	uc002wfc.2	-	1	1003	c.55G>T	c.(55-57)GAG>TAG	p.E19*	NSFL1C_uc002wfd.2_5'UTR|NSFL1C_uc002wfe.2_Nonsense_Mutation_p.E19*|NSFL1C_uc002wff.2_RNA	NM_016143	NP_057227	Q9UNZ2	NSF1C_HUMAN	p47 protein isoform a	19						chromosome|Golgi stack|nucleus	lipid binding|protein binding				0						CGGTCCTCCTCGGCGCCCGTC	0.746		NaN											1	0	0.00024832	0.000248	0.000295521	3	8									
CPXM1	56265	broad.mit.edu	37	20	2776510	2776510	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:2776510C>A	uc002wgu.2	-	11	1519	c.1455G>T	c.(1453-1455)TGG>TGT	p.W485C	CPXM1_uc010gas.2_Missense_Mutation_p.W485C	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	485					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						TCCGCTTCATCCACTTGATTA	0.637		NaN											1	0	1.96292e-10	0.001523	2.43673e-10	21	70									
ZNF133	7692	broad.mit.edu	37	20	18286394	18286394	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:18286394C>T	uc010gcq.2	+	3	369	c.64C>T	c.(64-66)CAA>TAA	p.Q22*	ZNF133_uc010zrv.1_Nonsense_Mutation_p.Q25*|ZNF133_uc010zrw.1_5'UTR|ZNF133_uc010gcr.2_Nonsense_Mutation_p.Q22*|ZNF133_uc010zrx.1_Intron|ZNF133_uc002wql.3_Nonsense_Mutation_p.Q22*|ZNF133_uc010gcs.2_Nonsense_Mutation_p.Q22*|ZNF133_uc010zry.1_Intron|ZNF133_uc002wqm.2_Nonsense_Mutation_p.Q22*	NM_003434	NP_003425	P52736	ZN133_HUMAN	zinc finger protein 133	22	KRAB.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)	2						GAGCCCTGCTCAAAGGACTCT	0.512		NaN											0	0	0	0.002096	0	30	69									
C20orf26	26074	broad.mit.edu	37	20	20177312	20177312	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:20177312C>G	uc002wru.2	+	16	1765	c.1689C>G	c.(1687-1689)CTC>CTG	p.L563L	C20orf26_uc010zse.1_Silent_p.L543L	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	563										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		ACTTTGCCCTCAACCCCATTT	0.463		NaN											0	0	0	0.002836	0	34	97									
THBD	7056	broad.mit.edu	37	20	23028421	23028421	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:23028421C>T	uc002wss.2	-	1	1881	c.1721G>A	c.(1720-1722)AGA>AAA	p.R574K	THBD_uc002wst.1_RNA	NM_000361	NP_000352	P07204	TRBM_HUMAN	thrombomodulin precursor	574	Cytoplasmic (Potential).				blood coagulation|leukocyte migration|negative regulation of fibrinolysis|negative regulation of platelet activation	cell surface|integral to plasma membrane	calcium ion binding|protein binding|transmembrane receptor activity				0	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)				Drotrecogin alfa(DB00055)	CGCTCAGAGTCTCTGCGGCGT	0.647		NaN											0	0	0	0.001168	0	6	8									
NCOA6	23054	broad.mit.edu	37	20	33370146	33370146	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:33370146C>G	uc002xav.2	-	4	2584	c.13G>C	c.(13-15)GAC>CAC	p.D5H	NCOA6_uc002xaw.2_Missense_Mutation_p.D5H|NCOA6_uc010gew.1_Missense_Mutation_p.D5H	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	5	TBP/GTF2A-binding region.|NCOA1-binding region.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						TTTGGAAGGTCATCCAAAACC	0.368		NaN											0	0	0	0.001855	0	14	47									
PROCR	10544	broad.mit.edu	37	20	33762609	33762609	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:33762609G>A	uc002xbt.2	+	2	359	c.175G>A	c.(175-177)GAA>AAA	p.E59K	EDEM2_uc010zuv.1_Intron|PROCR_uc010zuw.1_Missense_Mutation_p.E96K	NM_006404	NP_006395	Q9UNN8	EPCR_HUMAN	endothelial protein C receptor precursor	59	Extracellular (Potential).				antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity				0			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	GCACGTGCTGGAAGGCCCAGA	0.617		NaN											0	0	0	0.005443	0	27	75									
PROCR	10544	broad.mit.edu	37	20	33762683	33762683	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:33762683G>C	uc002xbt.2	+	2	433	c.249G>C	c.(247-249)CAG>CAC	p.Q83H	EDEM2_uc010zuv.1_Intron|PROCR_uc010zuw.1_Missense_Mutation_p.Q120H	NM_006404	NP_006395	Q9UNN8	EPCR_HUMAN	endothelial protein C receptor precursor	83	Extracellular (Potential).				antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity				0			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	CGCGCACGCAGAGTGGCCTGC	0.637		NaN											0	0	0	0.004482	0	9	14									
PROCR	10544	broad.mit.edu	37	20	33764071	33764071	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:33764071G>A	uc002xbt.2	+	3	607	c.423G>A	c.(421-423)GTG>GTA	p.V141V	EDEM2_uc010zuv.1_Intron|PROCR_uc010zuw.1_Silent_p.V178V	NM_006404	NP_006395	Q9UNN8	EPCR_HUMAN	endothelial protein C receptor precursor	141	Extracellular (Potential).				antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity				0			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	GCTCCTTTGTGAGTTTCCGGC	0.602		NaN											0	0	0	0.00874	0	39	120									
UQCC	55245	broad.mit.edu	37	20	33891806	33891806	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:33891806G>A	uc002xcd.2	-	10	899	c.832C>T	c.(832-834)CTA>TTA	p.L278L	UQCC_uc010zuy.1_Silent_p.L179L|UQCC_uc010zuz.1_Silent_p.L123L|UQCC_uc010zva.1_Silent_p.L141L|UQCC_uc002xce.2_Silent_p.L251L|UQCC_uc002xcg.2_Silent_p.L144L|UQCC_uc010gfb.2_Silent_p.L252L|UQCC_uc010zvb.1_Silent_p.L210L|UQCC_uc002xcf.2_Silent_p.L166L|UQCC_uc002xch.2_RNA|UQCC_uc002xcc.2_Silent_p.L91L	NM_018244	NP_060714	Q9NVA1	UQCC_HUMAN	basic FGF-repressed Zic binding protein isoform	278						cytoplasmic membrane-bounded vesicle				breast(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TTCTCCACTAGAGGGCGCCAG	0.607		NaN									OREG0025888	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	43	96									
CPNE1	8904	broad.mit.edu	37	20	34214245	34214245	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:34214245G>A	uc002xdf.2	-	18	1895	c.1532C>T	c.(1531-1533)TCA>TTA	p.S511L	CPNE1_uc002xdc.2_Missense_Mutation_p.S173L|CPNE1_uc010zvj.1_Missense_Mutation_p.S516L|CPNE1_uc002xde.2_Missense_Mutation_p.S487L|CPNE1_uc002xdg.2_Missense_Mutation_p.S455L|CPNE1_uc010gfi.2_RNA|CPNE1_uc010gfj.2_RNA|CPNE1_uc002xdh.2_Missense_Mutation_p.S511L|CPNE1_uc002xdi.2_Missense_Mutation_p.S511L|CPNE1_uc002xdj.2_Missense_Mutation_p.S511L|CPNE1_uc002xdk.2_Missense_Mutation_p.S511L|CPNE1_uc002xdl.2_Missense_Mutation_p.S511L|CPNE1_uc002xdm.2_Missense_Mutation_p.S511L	NM_152931	NP_690908	Q99829	CPNE1_HUMAN	copine I isoform a	511					lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			upper_aerodigestive_tract(1)	1	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			CCTGAAGTATGAGACCAGTTG	0.622		NaN											0	0	0	0.002852	0	43	141									
EPB41L1	2036	broad.mit.edu	37	20	34776319	34776319	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:34776319C>T	uc002xfb.2	+	9	1095	c.924C>T	c.(922-924)CTC>CTT	p.L308L	EPB41L1_uc002xeu.2_Silent_p.L246L|EPB41L1_uc010zvo.1_Silent_p.L308L|EPB41L1_uc002xev.2_Silent_p.L308L|EPB41L1_uc002xew.2_Silent_p.L211L|EPB41L1_uc002xex.2_Silent_p.L277L|EPB41L1_uc002xey.2_Silent_p.L235L|EPB41L1_uc002xez.2_Silent_p.L246L	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	308	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					ATGGCCTGCTCATCTACCGGG	0.562		NaN											0	0	0	0.005443	0	27	100									
CTNNBL1	56259	broad.mit.edu	37	20	36431360	36431360	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:36431360G>C	uc010zvw.1	+	12	1214	c.1123G>C	c.(1123-1125)GAC>CAC	p.D375H	CTNNBL1_uc002xhh.2_Missense_Mutation_p.D188H|CTNNBL1_uc002xhi.2_RNA|CTNNBL1_uc002xhj.2_Missense_Mutation_p.D123H	NM_030877	NP_110517	Q8WYA6	CTBL1_HUMAN	beta catenin-like 1	375					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			ovary(2)	2		Myeloproliferative disorder(115;0.00878)				TAAGTTTGTTGACATTCTTGG	0.483		NaN											0	0	0	0.003954	0	25	81									
DHX35	60625	broad.mit.edu	37	20	37662928	37662928	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:37662928G>C	uc002xjh.2	+	21	2046	c.2035G>C	c.(2035-2037)GAG>CAG	p.E679Q	DHX35_uc010zwa.1_Missense_Mutation_p.E524Q|DHX35_uc010zwb.1_Missense_Mutation_p.E524Q|DHX35_uc010zwc.1_Missense_Mutation_p.E648Q	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	679						catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CTGGCTGTTGGAGCTGGCTCC	0.448		NaN											0	0	0	0.005524	0	33	78									
DHX35	60625	broad.mit.edu	37	20	37662949	37662949	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:37662949C>G	uc002xjh.2	+	21	2067	c.2056C>G	c.(2056-2058)CAA>GAA	p.Q686E	DHX35_uc010zwa.1_Missense_Mutation_p.Q531E|DHX35_uc010zwb.1_Missense_Mutation_p.Q531E|DHX35_uc010zwc.1_Missense_Mutation_p.Q655E	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	686						catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				ACACTTTTATCAACAAGGAAC	0.448		NaN											0	0	0	0.005443	0	25	74									
ZHX3	23051	broad.mit.edu	37	20	39832342	39832342	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:39832342G>A	uc002xjs.1	-	3	1593	c.1215C>T	c.(1213-1215)CTC>CTT	p.L405L	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Silent_p.L405L|ZHX3_uc002xjt.1_Silent_p.L405L|ZHX3_uc002xju.1_Silent_p.L405L|ZHX3_uc002xjv.1_Silent_p.L405L|ZHX3_uc002xjw.1_Silent_p.L405L|ZHX3_uc010ggg.1_Silent_p.L405L	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	405	Required for homodimerization and interaction with NFYA.|Required for repressor activity.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				CGGCCTGGATGAGATGCTGGA	0.542		NaN											0	0	0	0.003954	0	24	100									
C20orf111	51526	broad.mit.edu	37	20	42825868	42825868	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:42825868C>G	uc002xlk.2	-	4	840	c.703G>C	c.(703-705)GAG>CAG	p.E235Q		NM_016470	NP_057554	Q9NX31	CT111_HUMAN	oxidative stress responsive 1	235											0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			GAGTAGTCCTCAAGTGTGGAT	0.522		NaN											0	0	0	0.006214	0	10	60									
MMP9	4318	broad.mit.edu	37	20	44642135	44642135	+	Silent	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:44642135C>A	uc002xqz.2	+	9	1591	c.1572C>A	c.(1570-1572)ATC>ATA	p.I524I		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	524	Hemopexin-like 1.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	TCGACGCCATCGCGGAGATTG	0.507		NaN									OREG0025990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	4.3838e-07	0.001855	5.30031e-07	12	19									
ZMYND8	23613	broad.mit.edu	37	20	45850058	45850058	+	Silent	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:45850058C>A	uc002xta.1	-	20	3518	c.3264G>T	c.(3262-3264)GGG>GGT	p.G1088G	ZMYND8_uc010ghq.1_Silent_p.G719G|ZMYND8_uc010ghr.1_Silent_p.G990G|ZMYND8_uc002xst.1_Silent_p.G970G|ZMYND8_uc002xsu.1_Silent_p.G961G|ZMYND8_uc002xsv.1_Silent_p.G1016G|ZMYND8_uc002xsw.1_Silent_p.G794G|ZMYND8_uc002xsx.1_Silent_p.G794G|ZMYND8_uc002xsy.1_Silent_p.G1017G|ZMYND8_uc002xsz.1_Silent_p.G979G|ZMYND8_uc010zxy.1_Silent_p.G1115G|ZMYND8_uc002xtb.1_Silent_p.G1062G|ZMYND8_uc002xss.2_Silent_p.G1088G|ZMYND8_uc010zxz.1_Silent_p.G956G|ZMYND8_uc002xtc.1_Silent_p.G1062G|ZMYND8_uc002xtd.1_Silent_p.G1037G|ZMYND8_uc002xte.1_Silent_p.G1042G|ZMYND8_uc010zya.1_Silent_p.G1088G|ZMYND8_uc002xtf.1_Silent_p.G1108G|ZMYND8_uc002xsr.1_Silent_p.G187G	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	1088							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TCGAGGAGCTCCCCTGGGAGG	0.547		NaN											1	0	3.6726e-16	0.003954	4.62286e-16	27	43									
NFATC2	4773	broad.mit.edu	37	20	50140246	50140246	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:50140246G>T	uc002xwd.2	-	2	754	c.534C>A	c.(532-534)TTC>TTA	p.F178L	NFATC2_uc002xwc.2_Missense_Mutation_p.F178L|NFATC2_uc010zyv.1_Intron|NFATC2_uc010zyw.1_Intron|NFATC2_uc010zyx.1_Missense_Mutation_p.F158L|NFATC2_uc010zyy.1_Intron|NFATC2_uc010zyz.1_Intron|NFATC2_uc002xwe.2_Missense_Mutation_p.F158L	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	178	Trans-activation domain A (TAD-A).				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					TGTCAGAAATGAAGCTGGCAG	0.647		NaN											1	0	6.94344e-10	0.006122	8.58245e-10	18	57									
C20orf85	128602	broad.mit.edu	37	20	56728648	56728648	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:56728648G>C	uc002xyv.2	+	2	155	c.117G>C	c.(115-117)CAG>CAC	p.Q39H		NM_178456	NP_848551	Q9H1P6	CT085_HUMAN	hypothetical protein LOC128602	39										ovary(1)	1	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			ACTGGCCCCAGAACTGGGGGT	0.433		NaN											0	0	0	0.007291	0	28	91									
NPEPL1	79716	broad.mit.edu	37	20	57268911	57268911	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:57268911C>T	uc010zzs.1	+	2	364	c.269C>T	c.(268-270)TCG>TTG	p.S90L	NPEPL1_uc010zzr.1_Missense_Mutation_p.S42L|NPEPL1_uc002xzn.2_RNA|NPEPL1_uc010gjo.1_Missense_Mutation_p.S62L|NPEPL1_uc002xzp.2_5'UTR	NM_024663	NP_078939	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	90					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity				0	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			AACAGCCCCTCGGCCGCCCAC	0.682		NaN											0	0	0	0.008291	0	10	47									
DIDO1	11083	broad.mit.edu	37	20	61526493	61526493	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:61526493C>G	uc002ydr.1	-	9	2503	c.2239G>C	c.(2239-2241)GAG>CAG	p.E747Q	DIDO1_uc002yds.1_Missense_Mutation_p.E747Q|DIDO1_uc002ydt.1_Missense_Mutation_p.E747Q|DIDO1_uc002ydu.1_Missense_Mutation_p.E747Q	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	747	TFIIS central.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GAGATTTCCTCACGCAGAACA	0.413		NaN											0	0	0	0.00361	0	66	191									
PRIC285	85441	broad.mit.edu	37	20	62198551	62198551	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:62198551G>C	uc002yfm.2	-	7	3052	c.2160C>G	c.(2158-2160)CTC>CTG	p.L720L	PRIC285_uc002yfl.1_Silent_p.L151L	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	720					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			AGCACAGGAAGAGGCGGTGCA	0.677		NaN											0	0	0	0.001368	0	12	49									
PRIC285	85441	broad.mit.edu	37	20	62198716	62198716	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:62198716G>C	uc002yfm.2	-	7	2887	c.1995C>G	c.(1993-1995)CTC>CTG	p.L665L	PRIC285_uc002yfl.1_Silent_p.L96L	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	665					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CCTCATCGATGAGAATGTGGG	0.706		NaN											0	0	0	0.004672	0	3	7									
PRIC285	85441	broad.mit.edu	37	20	62198913	62198913	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:62198913G>C	uc002yfm.2	-	7	2690	c.1798C>G	c.(1798-1800)CCT>GCT	p.P600A	PRIC285_uc002yfl.1_Missense_Mutation_p.P31A	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	600					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			ACACGGAGAGGAGTGGCCTCG	0.667		NaN											0	0	0	0.000602	0	4	8									
TNFRSF6B	8771	broad.mit.edu	37	20	62329778	62329778	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:62329778G>A	uc002yfy.2	+	7	1199	c.765G>A	c.(763-765)CTG>CTA	p.L255L	RTEL1_uc002yfw.2_RNA|TNFRSF6B_uc002yfz.2_Silent_p.L255L	NM_032945	NP_116563	O95407	TNF6B_HUMAN	tumor necrosis factor receptor superfamily,	255					anti-apoptosis|apoptosis	extracellular region|soluble fraction	protein binding|receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.66e-12)|all_epithelial(29;2.56e-13)|Lung NSC(23;1.06e-08)|all_lung(23;3.34e-08)		Epithelial(9;1.78e-08)|all cancers(9;7.89e-08)|OV - Ovarian serous cystadenocarcinoma(5;0.00504)			CCTTGCAGCTGAAGCTGCGTC	0.746		NaN											0	0	0	0.006214	0	9	14									
ARFRP1	10139	broad.mit.edu	37	20	62331869	62331869	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:62331869C>T	uc002yga.2	-	7	1099	c.532G>A	c.(532-534)GAG>AAG	p.E178K	ARFRP1_uc002ygc.2_Missense_Mutation_p.E178K|ARFRP1_uc002ygh.3_3'UTR|ARFRP1_uc011abf.1_3'UTR|ARFRP1_uc011abg.1_3'UTR|ARFRP1_uc002yge.2_RNA|ARFRP1_uc002ygd.2_RNA|ARFRP1_uc002ygf.2_Missense_Mutation_p.E178K|ARFRP1_uc002ygg.2_RNA|ARFRP1_uc011abh.1_RNA	NM_003224	NP_003215	Q13795	ARFRP_HUMAN	ADP-ribosylation factor related protein 1	178					small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|skin(1)	2	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)			TCGATGCCCTCGCGCACCCCT	0.701		NaN											0	0	0	0.006122	0	18	55									
NCAM2	4685	broad.mit.edu	37	21	22658708	22658708	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr21:22658708G>A	uc002yld.1	+	4	706	c.457G>A	c.(457-459)GAG>AAG	p.E153K	NCAM2_uc011acb.1_Intron|NCAM2_uc011acc.1_Missense_Mutation_p.E178K	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	153	Ig-like C2-type 2.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		GTATCATAATGAGGAAGTCAC	0.388		NaN											0	0	0	0.000978	0	9	63									
GRIK1	2897	broad.mit.edu	37	21	30927614	30927614	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr21:30927614T>C	uc002yno.1	-	16	2830	c.2366A>G	c.(2365-2367)TAC>TGC	p.Y789C	GRIK1_uc002ynn.2_Missense_Mutation_p.Y774C|GRIK1_uc011acs.1_Missense_Mutation_p.Y789C|GRIK1_uc011act.1_Missense_Mutation_p.Y650C	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	789	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TTTATCCCGGTAAGGAGAACC	0.403		NaN											0	0	0	0.006122	0	18	93									
TCP10L	140290	broad.mit.edu	37	21	33956596	33956596	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr21:33956596C>G	uc002ypw.3	-	2	135	c.19G>C	c.(19-21)GAG>CAG	p.E7Q	C21orf59_uc002ypx.1_Intron|C21orf59_uc002ypy.1_Intron|C21orf59_uc002ypz.1_Intron	NM_144659	NP_653260	Q9NV44	CU077_HUMAN	T-complex 10A-2	Error:Variant_position_missing_in_Q9NV44_after_alignment											0						TCCCTGGCCTCGAGTTGACCT	0.647		NaN											0	0	0	0.00245	0	14	36									
ITSN1	6453	broad.mit.edu	37	21	35183344	35183344	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr21:35183344G>A	uc002yta.1	+	21	2653	c.2385G>A	c.(2383-2385)TGG>TGA	p.W795*	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Nonsense_Mutation_p.W790*|ITSN1_uc010gmg.2_Nonsense_Mutation_p.W753*|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Nonsense_Mutation_p.W795*|ITSN1_uc010gmi.2_Nonsense_Mutation_p.W758*|ITSN1_uc010gmj.2_Nonsense_Mutation_p.W674*|ITSN1_uc002ysy.2_Nonsense_Mutation_p.W790*|ITSN1_uc002ysx.2_Nonsense_Mutation_p.W753*|ITSN1_uc002ytb.1_Nonsense_Mutation_p.W790*|ITSN1_uc002ytc.1_Nonsense_Mutation_p.W790*|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Nonsense_Mutation_p.W758*|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Nonsense_Mutation_p.W790*|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Nonsense_Mutation_p.W729*|ITSN1_uc002ytf.1_RNA	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	795	SH3 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						AGACAGGGTGGTTCCCTGCAA	0.483		NaN											0	0	0	0.008871	0	21	150									
CLDN14	23562	broad.mit.edu	37	21	37833718	37833718	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr21:37833718G>A	uc002yvk.1	-	2	418	c.276C>T	c.(274-276)GGC>GGT	p.G92G	CLDN14_uc002yvn.1_Silent_p.G92G|CLDN14_uc002yvo.1_Silent_p.G92G|CLDN14_uc002yvl.1_Silent_p.G92G|CLDN14_uc002yvm.1_Silent_p.G92G	NM_012130	NP_036262	O95500	CLD14_HUMAN	claudin 14	92	Helical; (Potential).				calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						CGCAGGCTATGCCCGAGAGCA	0.662		NaN											0	0	0	0.004656	0	26	36									
RIPK4	54101	broad.mit.edu	37	21	43171292	43171292	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr21:43171292C>G	uc002yzn.1	-	3	636	c.588G>C	c.(586-588)AAG>AAC	p.K196N		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	196						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						AGAGCCGGCTCTTCTCCCTGA	0.602		NaN											0	0	0	0.001984	0	7	79									
TRPM2	7226	broad.mit.edu	37	21	45838307	45838307	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr21:45838307G>C	uc002zet.1	+	23	3543	c.3330G>C	c.(3328-3330)AAG>AAC	p.K1110N	TRPM2_uc002zeu.1_Missense_Mutation_p.K1110N|TRPM2_uc002zew.1_Missense_Mutation_p.K1110N|TRPM2_uc010gpt.1_Missense_Mutation_p.K1110N|TRPM2_uc002zex.1_Missense_Mutation_p.K896N|TRPM2_uc002zey.1_Missense_Mutation_p.K623N|uc011afe.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1110	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCCTGACAGAGAACAAGCTGG	0.642		NaN											0	0	0	0.00308	0	7	57									
CECR5	27440	broad.mit.edu	37	22	17624010	17624010	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:17624010C>T	uc002zmf.2	-	5	577	c.549G>A	c.(547-549)AGG>AGA	p.R183R	CECR5_uc002zmd.2_5'Flank|CECR5_uc002zme.2_Intron|CECR5_uc002zmg.2_Silent_p.R46R|CECR5_uc002zmh.2_Silent_p.R153R	NM_033070	NP_149061	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	183							hydrolase activity				0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				GGAAGTCATTCCTCGGGAGGG	0.567		NaN											0	0	0	0.004007	0	16	52									
CDC45	8318	broad.mit.edu	37	22	19495340	19495340	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:19495340G>C	uc002zpr.2	+	12	1084	c.1008G>C	c.(1006-1008)TTG>TTC	p.L336F	CDC45_uc011agz.1_Missense_Mutation_p.L331F|CDC45_uc011aha.1_Missense_Mutation_p.L368F|CDC45_uc002zps.2_Missense_Mutation_p.L336F|CDC45_uc002zpt.2_Missense_Mutation_p.L290F	NM_003504	NP_003495	O75419	CDC45_HUMAN	CDC45-like	336					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			lung(1)	1						ACATCTCCTTGAAGGAGAATT	0.443		NaN											0	0	0	0.00361	0	50	95									
RTN4R	65078	broad.mit.edu	37	22	20229926	20229926	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:20229926C>T	uc002zrv.2	-	2	931	c.730G>A	c.(730-732)GAG>AAG	p.E244K	RTN4R_uc002zru.2_Missense_Mutation_p.E16K	NM_023004	NP_075380	Q9BZR6	RTN4R_HUMAN	reticulon 4 receptor precursor	244	LRR 8.				axonogenesis|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|cell surface|endoplasmic reticulum|plasma membrane	protein binding|receptor activity				0	Colorectal(54;0.0993)					GCCAGGGCCTCAGTGGGCAGC	0.642		NaN											0	0	0	0.008871	0	19	32									
SERPIND1	3053	broad.mit.edu	37	22	21138315	21138315	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:21138315G>A	uc002ztb.1	+	3	1012	c.945G>A	c.(943-945)CTG>CTA	p.L315L	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Silent_p.L343L	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	315					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	ACTTCCGGCTGAATGAGAGAG	0.493		NaN									OREG0026325	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	86	184									
MTMR3	8897	broad.mit.edu	37	22	30394779	30394779	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:30394779G>C	uc003agv.3	+	8	818	c.490G>C	c.(490-492)GAG>CAG	p.E164Q	MTMR3_uc003agu.3_Missense_Mutation_p.E164Q|MTMR3_uc003agw.3_Missense_Mutation_p.E164Q	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	164	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			GTTTAAAAACGAGGTGGAGAG	0.408		NaN											0	0	0	0.001168	0	6	21									
TCN2	6948	broad.mit.edu	37	22	31011378	31011378	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:31011378G>C	uc003aip.1	+	5	829	c.671G>C	c.(670-672)AGA>ACA	p.R224T	TCN2_uc003aiq.1_Missense_Mutation_p.R220T|TCN2_uc003air.1_Missense_Mutation_p.R197T	NM_000355	NP_000346	P20062	TCO2_HUMAN	transcobalamin II precursor	224					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular space	cobalamin binding			central_nervous_system(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATGGCCATCAGAACAGTGCGA	0.562		NaN											0	0	0	0.003271	0	34	78									
DEPDC5	9681	broad.mit.edu	37	22	32188758	32188758	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:32188758C>G	uc003als.2	+	12	864	c.722C>G	c.(721-723)TCA>TGA	p.S241*	DEPDC5_uc011als.1_Nonsense_Mutation_p.S241*|DEPDC5_uc011alu.1_Nonsense_Mutation_p.S241*|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Nonsense_Mutation_p.S241*|DEPDC5_uc003alr.1_Nonsense_Mutation_p.S241*|DEPDC5_uc011alt.1_Nonsense_Mutation_p.S213*	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	241					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						AACCGAGCCTCAATTCGACAG	0.363		NaN											0	0	0	0.005443	0	24	63									
SLC5A4	6527	broad.mit.edu	37	22	32627028	32627028	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:32627028C>G	uc003ami.2	-	10	1058	c.1056G>C	c.(1054-1056)GTG>GTC	p.V352V		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	352	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						CACAGTGTTTCACGCATTCAG	0.493		NaN											0	0	0	0.00499	0	13	46									
MYH9	4627	broad.mit.edu	37	22	36745254	36745254	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:36745254G>C	uc003apg.2	-	2	259	c.28C>G	c.(28-30)CTC>GTC	p.L10V	MYH9_uc003api.1_Missense_Mutation_p.L10V	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	10	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TCCACATAGAGATACTTATCG	0.517		NaN	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.001855	0	13	42									
CARD10	29775	broad.mit.edu	37	22	37902202	37902202	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:37902202G>C	uc003asx.1	-	7	1383	c.1380C>G	c.(1378-1380)CTC>CTG	p.L460L	CARD10_uc003ast.1_RNA|CARD10_uc003asw.1_Silent_p.L174L|CARD10_uc003asy.1_Silent_p.L460L	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	460					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					CGCTCACCTTGAGGCAGGTGC	0.672		NaN											0	0	0	0.007413	0	14	30									
APOBEC3D	140564	broad.mit.edu	37	22	39378461	39378461	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:39378461G>C	uc011aoe.1	+	1	57	c.3G>C	c.(1-3)ATG>ATC	p.M1I	APOBEC3A_uc011aoc.1_Intron|APOBEC3B_uc003awo.1_Missense_Mutation_p.M1I|APOBEC3B_uc003awp.1_Missense_Mutation_p.M1I|APOBEC3B_uc003awq.1_RNA|APOBEC3D_uc011aod.1_Missense_Mutation_p.M1I|APOBEC3D_uc011aof.1_Missense_Mutation_p.M1I	NM_152426	NP_689639	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	1					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0	Melanoma(58;0.04)					GGCTGAACATGAATCCACAGA	0.597		NaN											0	0	0	0.002445	0	30	19									
APOBEC3G	60489	broad.mit.edu	37	22	39483104	39483104	+	Silent	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:39483104G>T	uc003awx.2	+	7	1455	c.1113G>T	c.(1111-1113)CTG>CTT	p.L371L	APOBEC3G_uc003awy.2_Silent_p.L304L	NM_021822	NP_068594	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	371					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2	Melanoma(58;0.04)					GCCAAGACCTGAGTGGGAGGC	0.483		NaN											1	0	6.07407e-21	0.007291	7.71311e-21	27	70									
TNRC6B	23112	broad.mit.edu	37	22	40661277	40661277	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:40661277C>G	uc011aor.1	+	5	1254	c.1043C>G	c.(1042-1044)TCA>TGA	p.S348*	TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Nonsense_Mutation_p.S348*|TNRC6B_uc003ayo.2_Nonsense_Mutation_p.S152*	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	348					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						GAACAGCAGTCAAAGATGGAA	0.428		NaN											0	0	0	0.003954	0	24	64									
EFCAB6	64800	broad.mit.edu	37	22	44083357	44083357	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:44083357C>T	uc003bdy.1	-	11	1351	c.1136G>A	c.(1135-1137)AGA>AAA	p.R379K	EFCAB6_uc003bdz.1_Missense_Mutation_p.R227K|EFCAB6_uc010gzi.1_Missense_Mutation_p.R227K|EFCAB6_uc010gzk.1_Intron|EFCAB6_uc011aqa.1_Intron|EFCAB6_uc003bea.1_Missense_Mutation_p.R376K	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	379					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				ATACCTATTTCTTTTTGTCAG	0.308		NaN											0	0	0	0.006214	0	6	42									
CELSR1	9620	broad.mit.edu	37	22	46759985	46759985	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:46759985C>T	uc003bhw.1	-	34	8943	c.8943G>A	c.(8941-8943)AAG>AAA	p.K2981K		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2981	Cytoplasmic (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCCCAGGGCTCTTGACTGTGA	0.687		NaN											0	0	0	0.002299	0	22	50									
CELSR1	9620	broad.mit.edu	37	22	46859643	46859643	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:46859643C>T	uc003bhw.1	-	2	4144	c.4144G>A	c.(4144-4146)GAG>AAG	p.E1382K		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1382	Extracellular (Potential).|EGF-like 2; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TAGCCGCCCTCGCGGCTGCGG	0.687		NaN											0	0	0	0.001168	0	5	15									
MLC1	23209	broad.mit.edu	37	22	50523236	50523236	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:50523236C>T	uc003bjg.1	-	2	369	c.96G>A	c.(94-96)GCG>GCA	p.A32A	MLC1_uc011arl.1_Silent_p.A32A|MLC1_uc003bjh.1_Silent_p.A32A|MLC1_uc011arm.1_Silent_p.A32A|MLC1_uc011arn.1_Intron|MLC1_uc011aro.1_Silent_p.A32A	NM_139202	NP_631941	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with	32						basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			pancreas(1)	1		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)		CGCTCGGCTTCGCGTCTGGGG	0.637		NaN											0	0	0	0.001882	0	22	54									
TUBGCP6	85378	broad.mit.edu	37	22	50657502	50657502	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:50657502C>G	uc003bkb.1	-	20	5133	c.4621G>C	c.(4621-4623)GAG>CAG	p.E1541Q	TUBGCP6_uc003bka.1_Missense_Mutation_p.E628Q|TUBGCP6_uc010har.1_Missense_Mutation_p.E1533Q|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1541					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GCCACCTTCTCAAAGAGCAGG	0.657		NaN											0	0	0	0.000602	0	4	47									
EDEM1	9695	broad.mit.edu	37	3	5246762	5246762	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:5246762G>C	uc003bqi.2	+	6	1185	c.1053G>C	c.(1051-1053)GTG>GTC	p.V351V	EDEM1_uc011asz.1_Silent_p.V129V|EDEM1_uc003bqh.2_Silent_p.V351V	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	351	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		GCAATGTCGTGAACATTCAGA	0.517		NaN											0	0	0	0.00361	0	60	76									
C3orf24	115795	broad.mit.edu	37	3	10146088	10146088	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:10146088G>A	uc003buz.2	-	2	596	c.371C>T	c.(370-372)TCA>TTA	p.S124L	C3orf24_uc003bva.1_Missense_Mutation_p.S124L	NM_173472	NP_775743	Q96PS1	CC024_HUMAN	hypothetical protein LOC115795	124											0				OV - Ovarian serous cystadenocarcinoma(96;0.196)		GCAAAAGGCTGACTTGTCTGA	0.522		NaN											0	0	0	0.00278	0	23	173									
PPARG	5468	broad.mit.edu	37	3	12458253	12458253	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:12458253C>G	uc003bwx.2	+	6	961	c.870C>G	c.(868-870)ATC>ATG	p.I290M	PPARG_uc003bwr.2_Missense_Mutation_p.I262M|PPARG_uc003bws.2_Missense_Mutation_p.I262M|PPARG_uc003bwu.2_Missense_Mutation_p.I262M|PPARG_uc003bwv.2_Intron|PPARG_uc010hea.1_RNA	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	290					activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	AAGATAAAATCAAGTTCAAAC	0.473		NaN	T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						0	0	0	0.00499	0	17	27									
ANKRD28	23243	broad.mit.edu	37	3	15762601	15762601	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:15762601G>C	uc003caj.1	-	8	870	c.727C>G	c.(727-729)CTT>GTT	p.L243V	ANKRD28_uc003cai.1_Missense_Mutation_p.L89V|ANKRD28_uc011avz.1_Missense_Mutation_p.L89V|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Missense_Mutation_p.L273V|ANKRD28_uc003cam.2_Missense_Mutation_p.L276V	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	243	ANK 7.					nucleoplasm	protein binding			breast(1)	1						GCTACATGAAGAGGTGTATTT	0.328		NaN											0	0	0	0.00361	0	59	471									
TRANK1	9881	broad.mit.edu	37	3	36899292	36899292	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:36899292G>A	uc003cgj.2	-	3	441	c.139C>T	c.(139-141)CTG>TTG	p.L47L		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	597					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GCCAAGAGCAGAGAGTCGTTC	0.532		NaN											0	0	0	0.002836	0	34	213									
LRRFIP2	9209	broad.mit.edu	37	3	37151043	37151043	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:37151043G>A	uc003cgp.2	-	12	1007	c.584C>T	c.(583-585)TCT>TTT	p.S195F	LRRFIP2_uc011ayf.1_Intron|LRRFIP2_uc003cgr.2_Intron|LRRFIP2_uc003cgs.3_Intron|LRRFIP2_uc003cgt.3_Intron	NM_006309	NP_006300	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting	195	DVL3-binding.|Ser-rich.				Wnt receptor signaling pathway		LRR domain binding			ovary(1)	1						CAGCAGACCAGAATTTGCAGT	0.438		NaN											0	0	0	0.00361	0	48	75									
SCN10A	6336	broad.mit.edu	37	3	38739903	38739903	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:38739903G>T	uc003ciq.2	-	27	4808	c.4808C>A	c.(4807-4809)TCC>TAC	p.S1603Y		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1603	IV.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGCAGGCAGGGACATCATGAG	0.562		NaN											1	0	5.61819e-17	0.005443	7.09044e-17	27	124									
SCN10A	6336	broad.mit.edu	37	3	38743465	38743465	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:38743465G>C	uc003ciq.2	-	26	4522	c.4522C>G	c.(4522-4524)CTG>GTG	p.L1508V		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1508	IV.|Helical; Name=S2 of repeat IV; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ATTTTGCCCAGAATTTTCGTC	0.448		NaN											0	0	0	0.00245	0	14	94									
SCN11A	11280	broad.mit.edu	37	3	38962667	38962667	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:38962667G>A	uc011ays.1	-	6	991	c.792C>T	c.(790-792)CTC>CTT	p.L264L		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	264	Helical; Name=S5 of repeat I; (By similarity).|I.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CAAAGATGCTGAGGCAAAAGA	0.498		NaN											0	0	0	0.002836	0	34	252									
ENTPD3	956	broad.mit.edu	37	3	40457535	40457535	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:40457535G>C	uc003ckd.3	+	7	894	c.802G>C	c.(802-804)GAG>CAG	p.E268Q	ENTPD3_uc010hhy.2_Missense_Mutation_p.E268Q|uc003cke.3_Intron	NM_001248	NP_001239	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase	268	Extracellular (Potential).					integral to membrane	ATP binding|hydrolase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		GAATGAGGCTGAGAAGAAGTT	0.552		NaN											0	0	0	0.00499	0	18	36									
CSPG5	10675	broad.mit.edu	37	3	47619161	47619161	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:47619161C>T	uc003crp.3	-	2	531	c.355G>A	c.(355-357)GAT>AAT	p.D119N	CSPG5_uc003crn.2_5'UTR|CSPG5_uc003cro.3_Missense_Mutation_p.D119N|CSPG5_uc011bbb.1_5'UTR	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	119	Extracellular (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GCCTGGGCATCGCCGCTGCCC	0.692		NaN											0	0	0	0.00499	0	16	82									
COL7A1	1294	broad.mit.edu	37	3	48612779	48612779	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:48612779C>T	uc003ctz.2	-	73	6174	c.6173G>A	c.(6172-6174)GGA>GAA	p.G2058E		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2058	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CACCCTCTCTCCTGGCCTTCC	0.697		NaN											0	0	0	0.007291	0	26	30									
CELSR3	1951	broad.mit.edu	37	3	48697852	48697852	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:48697852G>A	uc003cul.2	-	1	2497	c.2216C>T	c.(2215-2217)TCA>TTA	p.S739L	CELSR3_uc003cuf.1_Missense_Mutation_p.S809L	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	739	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GACACTGGCTGAGGCAGAGAG	0.567		NaN											0	0	0	0.007835	0	34	53									
CELSR3	1951	broad.mit.edu	37	3	48698805	48698805	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:48698805C>G	uc003cul.2	-	1	1544	c.1263G>C	c.(1261-1263)GTG>GTC	p.V421V	CELSR3_uc003cuf.1_Silent_p.V491V	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	421	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGGCTACTGTCACGGCCACCA	0.662		NaN											0	0	0	0.004289	0	36	53									
PRKAR2A	5576	broad.mit.edu	37	3	48820513	48820513	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:48820513G>T	uc010hki.1	-	5	689	c.448C>A	c.(448-450)CAA>AAA	p.Q150K	PRKAR2A_uc003cux.1_Missense_Mutation_p.Q150K|PRKAR2A_uc003cuy.1_Missense_Mutation_p.Q150K	NM_004157	NP_004148	P13861	KAP2_HUMAN	cAMP-dependent protein kinase, regulatory	150	cAMP 1.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|membrane fraction	cAMP binding|cAMP-dependent protein kinase regulator activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000176)|Kidney(197;0.00246)|KIRC - Kidney renal clear cell carcinoma(197;0.00261)		TCGAGAACTTGAGAAAGCTGT	0.383		NaN											1	0	4.68919e-08	0.008291	5.70789e-08	10	67									
WDR6	11180	broad.mit.edu	37	3	49049462	49049462	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:49049462G>A	uc003cvj.2	+	2	723	c.585G>A	c.(583-585)CTG>CTA	p.L195L	WDR6_uc011bbx.1_Silent_p.L66L|WDR6_uc011bby.1_Intron|WDR6_uc010hkn.2_Silent_p.L139L|WDR6_uc011bbz.1_Silent_p.L114L	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	165	WD 2.				cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		CAGCCTGCCTGATTGGAGACG	0.567		NaN											0	0	0	0.001168	0	6	50									
SEMA3F	6405	broad.mit.edu	37	3	50211515	50211515	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:50211515G>A	uc003cyj.2	+	4	502	c.304G>A	c.(304-306)GAG>AAG	p.E102K	SEMA3F_uc003cyk.2_Missense_Mutation_p.E102K	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	102	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		ACAGCGCATCGAGGAATGCGT	0.627		NaN											0	0	0	0.004878	0	38	37									
HYAL2	8692	broad.mit.edu	37	3	50357236	50357236	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:50357236C>T	uc003czu.2	-	2	905	c.685G>A	c.(685-687)GAT>AAT	p.D229N	HYAL2_uc003czx.2_Missense_Mutation_p.D229N|HYAL2_uc003czv.2_Missense_Mutation_p.D229N|HYAL2_uc003czw.2_Missense_Mutation_p.D229N|HYAL2_uc010hlj.2_Missense_Mutation_p.D229N	NM_033158	NP_149348	Q12891	HYAL2_HUMAN	hyaluronoglucosaminidase 2 precursor	229						anchored to membrane|lysosome|plasma membrane	hyalurononglucosaminidase activity|receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)	Hyaluronidase(DB00070)	ACCTCAACATCAGGGCAGCGG	0.612		NaN											0	0	0	0.004007	0	17	32									
NT5DC2	64943	broad.mit.edu	37	3	52558487	52558487	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:52558487C>T	uc003deo.2	-	14	1986	c.1562G>A	c.(1561-1563)TGA>TAA	p.*521*	NT5DC2_uc003dem.2_Silent_p.*391*|NT5DC2_uc003den.2_Silent_p.*558*|NT5DC2_uc010hmi.2_Silent_p.*533*|NT5DC2_uc010hmj.2_Silent_p.*337*|STAB1_uc003dej.2_3'UTR|STAB1_uc003del.2_3'UTR	NM_022908	NP_075059	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2 isoform 2	521							hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		AAGGTGCCCTCAGCGGATGTG	0.612		NaN											0	0	0	0.00361	0	98	110									
PBRM1	55193	broad.mit.edu	37	3	52643561	52643561	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:52643561G>C	uc003des.2	-	16	2347	c.2335C>G	c.(2335-2337)CAA>GAA	p.Q779E	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.Q779E|PBRM1_uc003der.2_Missense_Mutation_p.Q747E|PBRM1_uc003det.2_Missense_Mutation_p.Q794E|PBRM1_uc003deu.2_Missense_Mutation_p.Q794E|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.Q779E|PBRM1_uc010hmk.1_Missense_Mutation_p.Q779E|PBRM1_uc003dey.2_Missense_Mutation_p.Q779E|PBRM1_uc003dez.1_Missense_Mutation_p.Q779E|PBRM1_uc003dfb.1_Missense_Mutation_p.Q692E|PBRM1_uc003dfa.1_Missense_Mutation_p.Q125E|PBRM1_uc003dfc.2_Missense_Mutation_p.Q146E	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	779					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding	p.Q779*(3)		kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		ATAAGCTCTTGAATCAGCAAA	0.448		NaN	Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	0.003755	0	36	43									
PBRM1	55193	broad.mit.edu	37	3	52696218	52696218	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:52696218C>T	uc003des.2	-	4	471	c.459G>A	c.(457-459)CAG>CAA	p.Q153Q	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Silent_p.Q153Q|PBRM1_uc003der.2_Silent_p.Q153Q|PBRM1_uc003det.2_Silent_p.Q153Q|PBRM1_uc003deu.2_Silent_p.Q153Q|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Silent_p.Q153Q|PBRM1_uc010hmk.1_Silent_p.Q153Q|PBRM1_uc003dey.2_Silent_p.Q153Q|PBRM1_uc003dez.1_Silent_p.Q153Q|PBRM1_uc003dfb.1_Silent_p.Q51Q	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	153					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CTTCTCCTTTCTGAACAAACT	0.418		NaN	Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	0.001786	0	32	217									
CACNA1D	776	broad.mit.edu	37	3	53783406	53783406	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:53783406C>T	uc003dgv.3	+	27	3589	c.3426C>T	c.(3424-3426)TTC>TTT	p.F1142F	CACNA1D_uc003dgu.3_Silent_p.F1162F|CACNA1D_uc003dgy.3_Silent_p.F1142F|CACNA1D_uc003dgw.3_Silent_p.F809F|CACNA1D_uc003dgx.1_Silent_p.F290F	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1142	Helical; Name=S6 of repeat III; (Potential).|Dihydropyridine binding (By similarity).|III.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TAGCTTTCTTCATGATGAACA	0.418		NaN											0	0	0	0.002096	0	33	44									
ERC2	26059	broad.mit.edu	37	3	55733504	55733504	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:55733504C>T	uc003dhr.1	-	16	3005	c.2749G>A	c.(2749-2751)GAT>AAT	p.D917N	ERC2_uc003dhq.1_RNA	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	917	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		tggtCATCATCATAGTTGTCT	0.383		NaN											0	0	0	0.00361	0	121	193									
MAGI1	9223	broad.mit.edu	37	3	65342307	65342307	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:65342307C>T	uc003dmn.2	-	23	4661	c.4135G>A	c.(4135-4137)GAG>AAG	p.E1379K	MAGI1_uc003dmm.2_3'UTR	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1408					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CTCCTCTGCTCCAGGAGTCTC	0.726		NaN											0	0	0	0.002299	0	22	58									
LRIG1	26018	broad.mit.edu	37	3	66434683	66434683	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:66434683G>A	uc003dmx.2	-	14	1817	c.1803C>T	c.(1801-1803)TTC>TTT	p.F601F	SLC25A26_uc011bft.1_Intron|LRIG1_uc011bfu.1_Silent_p.F221F|LRIG1_uc003dmw.2_Silent_p.F267F|LRIG1_uc010hnz.2_Silent_p.F317F|LRIG1_uc010hoa.2_Silent_p.F625F	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	601	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GCGTTTTGGTGAATGATGGCA	0.547		NaN											0	0	0	0.00361	0	56	283									
LRIG1	26018	broad.mit.edu	37	3	66502041	66502041	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:66502041C>T	uc003dmx.2	-	3	321	c.307G>A	c.(307-309)GAG>AAG	p.E103K	LRIG1_uc010hnz.2_5'UTR|LRIG1_uc010hoa.2_Missense_Mutation_p.E103K	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	103	Extracellular (Potential).|LRR 2.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GCTGTCAACTCATTATTATTG	0.438		NaN											0	0	0	0.00361	0	51	68									
GXYLT2	727936	broad.mit.edu	37	3	73016856	73016856	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:73016856G>A	uc003dpg.2	+	6	1135	c.1135G>A	c.(1135-1137)GAA>AAA	p.E379K		NM_001080393	NP_001073862	A0PJZ3	GXLT2_HUMAN	glycosyltransferase 8 domain containing 4	379	Lumenal (Potential).				O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0						AGCACTCTATGAAGCAATACG	0.493		NaN											0	0	0	0.008291	0	9	38									
CGGBP1	8545	broad.mit.edu	37	3	88104904	88104904	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:88104904C>T	uc003dqs.2	-	4	735	c.223G>A	c.(223-225)GAA>AAA	p.E75K	CGGBP1_uc003dqt.2_Missense_Mutation_p.E75K|CGGBP1_uc003dqu.2_Missense_Mutation_p.E75K	NM_001008390	NP_001008391	Q9UFW8	CGBP1_HUMAN	CGG triplet repeat binding protein 1	75					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding				0		Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00359)|Lung(72;0.00677)		TTCTGCTCTTCAAATTCTGCC	0.453		NaN											0	0	0	0.003163	0	15	112									
TMEM45A	55076	broad.mit.edu	37	3	100277340	100277340	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:100277340C>T	uc003dtz.1	+	4	808	c.495C>T	c.(493-495)CTC>CTT	p.L165L	TMEM45A_uc003dua.1_Silent_p.L181L	NM_018004	NP_060474	Q9NWC5	TM45A_HUMAN	transmembrane protein 45A	165	Helical; (Potential).					integral to membrane				skin(2)|ovary(1)	3						TGACAGGCCTCGTTGCCTTCC	0.502		NaN											0	0	0	0.008361	0	32	178									
GPR128	84873	broad.mit.edu	37	3	100413798	100413798	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:100413798G>A	uc003duc.2	+	16	2615	c.2347G>A	c.(2347-2349)GAG>AAG	p.E783K	GPR128_uc011bhc.1_Missense_Mutation_p.E484K|GPR128_uc003dud.2_Missense_Mutation_p.E306K	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	783	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						TCCGAGTACTGAGGAAATCAC	0.433		NaN											0	0	0	0.00499	0	18	69									
IMPG2	50939	broad.mit.edu	37	3	100961751	100961751	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:100961751G>A	uc003duq.1	-	14	3006	c.2803C>T	c.(2803-2805)CTG>TTG	p.L935L	IMPG2_uc011bhe.1_Silent_p.L798L	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	935	Extracellular (Potential).|SEA 2.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TAGGGAACCAGCTACAATATA	0.403		NaN											0	0	0	0.003954	0	25	69									
PHLDB2	90102	broad.mit.edu	37	3	111667878	111667878	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:111667878G>A	uc010hqa.2	+	10	2998	c.2587G>A	c.(2587-2589)GAG>AAG	p.E863K	PHLDB2_uc003dyc.2_Missense_Mutation_p.E847K|PHLDB2_uc003dyd.2_Missense_Mutation_p.E820K|PHLDB2_uc003dyg.2_Missense_Mutation_p.E863K|PHLDB2_uc003dyh.2_Missense_Mutation_p.E820K|PHLDB2_uc003dyi.2_Intron	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	863						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						TGTTGCCACTGAGCCTGCCAC	0.478		NaN											0	0	0	0.004007	0	16	39									
GCET2	257144	broad.mit.edu	37	3	111851948	111851948	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:111851948C>G	uc003dys.1	-	1	170	c.20G>C	c.(19-21)AGA>ACA	p.R7T	GCET2_uc003dyt.1_5'UTR	NM_152785	NP_689998	Q8N6F7	GCET2_HUMAN	germinal center expressed transcript 2 isoform	7						mitochondrion					0						CCTGTTTTCTCTCAGCAGAGA	0.502		NaN											0	0	0	0.002836	0	30	169									
BTLA	151888	broad.mit.edu	37	3	112185019	112185019	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:112185019G>C	uc003dza.3	-	5	1009	c.806C>G	c.(805-807)TCA>TGA	p.S269*	BTLA_uc003dzb.3_Nonsense_Mutation_p.S221*	NM_181780	NP_861445	Q7Z6A9	BTLA_HUMAN	B and T lymphocyte associated isoform 1	269	Cytoplasmic (Potential).				T cell costimulation		receptor activity				0		Acute lymphoblastic leukemia(4;1.34e-07)|all_hematologic(4;0.000361)				TGCCAGTCTTGAGTTCGGTCC	0.418		NaN											0	0	0	0.004289	0	35	90									
KIAA2018	205717	broad.mit.edu	37	3	113378767	113378767	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:113378767G>C	uc003eam.2	-	7	2173	c.1762C>G	c.(1762-1764)CAG>GAG	p.Q588E	KIAA2018_uc003eal.2_Missense_Mutation_p.Q532E	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	588					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						AAAGGATTCTGATTAGCAGCC	0.478		NaN											0	0	0	0.008871	0	21	102									
RABL3	285282	broad.mit.edu	37	3	120461334	120461334	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:120461334C>T	uc003edx.2	-	1	51	c.21G>A	c.(19-21)GTG>GTA	p.V7V	GTF2E1_uc003edy.2_5'Flank|GTF2E1_uc003edz.3_5'Flank	NM_173825	NP_776186	Q5HYI8	RABL3_HUMAN	RAB, member of RAS oncogene family-like 3	7	Small GTPase-like.				small GTPase mediated signal transduction		GTP binding				0				GBM - Glioblastoma multiforme(114;0.151)		CCAGTACCTTCACCCGATCCA	0.567		NaN											0	0	0	0.004482	0	9	76									
SLC15A2	6565	broad.mit.edu	37	3	121630438	121630438	+	Missense_Mutation	SNP	C	C	G	rs138471341		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:121630438C>G	uc003eep.2	+	4	506	c.353C>G	c.(352-354)TCC>TGC	p.S118C	SLC15A2_uc011bjn.1_Intron	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	118	Helical; (Potential).				protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding	p.S118F(1)		skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	ATCTATCTCTCCTTGGTGTAT	0.418		NaN											0	0	0	0.00333	0	22	30									
SLC41A3	54946	broad.mit.edu	37	3	125735707	125735707	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:125735707G>C	uc003eij.2	-	7	983	c.757C>G	c.(757-759)CTG>GTG	p.L253V	SLC41A3_uc003eii.2_Missense_Mutation_p.L227V|SLC41A3_uc003eil.2_Missense_Mutation_p.L253V|SLC41A3_uc003eik.2_Missense_Mutation_p.L217V|SLC41A3_uc011bkh.1_Missense_Mutation_p.L136V|SLC41A3_uc010hsd.1_Missense_Mutation_p.L268V	NM_001008485	NP_001008485	Q96GZ6	S41A3_HUMAN	solute carrier family 41, member 3 isoform 1	253	Helical; (Potential).					integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(114;0.167)		AGCGGCGTCAGATACCGACTA	0.582		NaN											0	0	0	0.004672	0	3	41									
ZXDC	79364	broad.mit.edu	37	3	126193905	126193905	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:126193905G>C	uc003eiv.2	-	1	858	c.804C>G	c.(802-804)TTC>TTG	p.F268L	ZXDC_uc010hsh.2_RNA|ZXDC_uc003eix.2_Missense_Mutation_p.F268L	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	268	C2H2-type 4.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		CCTCGCACTTGAACAGGCTCT	0.627		NaN											0	0	0	0.000248	0	3	13									
IFT122	55764	broad.mit.edu	37	3	129214429	129214429	+	Silent	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:129214429C>A	uc003emm.2	+	18	2393	c.2187C>A	c.(2185-2187)CTC>CTA	p.L729L	IFT122_uc003eml.2_Silent_p.L780L|IFT122_uc003emn.2_Silent_p.L670L|IFT122_uc003emo.2_Silent_p.L618L|IFT122_uc003emp.2_Silent_p.L579L|IFT122_uc010htc.2_Silent_p.L721L|IFT122_uc011bky.1_Silent_p.L520L|IFT122_uc003emq.2_Silent_p.L569L|IFT122_uc003emr.2_Silent_p.L481L|IFT122_uc011bla.1_Silent_p.L502L|IFT122_uc010hte.2_Intron|IFT122_uc003ems.2_Silent_p.L110L|IFT122_uc011bkx.1_Silent_p.L569L|IFT122_uc010htd.1_Silent_p.L208L	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	729					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						ACACCGACCTCTGCATGTTTG	0.527		NaN											1	0	2.27731e-05	0.001882	2.73277e-05	20	48									
IFT122	55764	broad.mit.edu	37	3	129231193	129231193	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:129231193C>G	uc003emm.2	+	24	3131	c.2925C>G	c.(2923-2925)TTC>TTG	p.F975L	IFT122_uc003eml.2_Missense_Mutation_p.F1026L|IFT122_uc003emn.2_Missense_Mutation_p.F916L|IFT122_uc003emo.2_Missense_Mutation_p.F865L|IFT122_uc003emp.2_Missense_Mutation_p.F825L|IFT122_uc010htc.2_Missense_Mutation_p.F968L|IFT122_uc011bky.1_Missense_Mutation_p.F766L|IFT122_uc003emq.2_Missense_Mutation_p.F815L|IFT122_uc003emr.2_Missense_Mutation_p.F728L|IFT122_uc011bla.1_Missense_Mutation_p.F749L|IFT122_uc010hte.2_Missense_Mutation_p.F301L|IFT122_uc003ems.2_Missense_Mutation_p.F357L|IFT122_uc011bkx.1_Missense_Mutation_p.F816L	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	975					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						AAACTCTTTTCAACATCTCCA	0.537		NaN											0	0	0	0.00361	0	45	201									
PLXND1	23129	broad.mit.edu	37	3	129290635	129290635	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:129290635G>C	uc003emx.2	-	16	3230	c.3130C>G	c.(3130-3132)CCG>GCG	p.P1044A		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1044	Extracellular (Potential).|IPT/TIG 2.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						ACAGGCACCGGAGCCGGCAGG	0.662		NaN											0	0	0	0.000602	0	5	27									
MSL2	55167	broad.mit.edu	37	3	135913868	135913868	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:135913868C>T	uc003eqx.1	-	1	821	c.88G>A	c.(88-90)GAG>AAG	p.E30K	MSL2_uc011bmb.1_5'Flank	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	30					histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1						CTGTTAATCTCAGTAAACGCC	0.493		NaN											0	0	0	0.00361	0	99	160									
ESYT3	83850	broad.mit.edu	37	3	138195290	138195290	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:138195290G>A	uc003esk.2	+	22	2806	c.2580G>A	c.(2578-2580)CTG>CTA	p.L860L		NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	860	C2 3.					integral to membrane|plasma membrane					0						TTTAGGTACTGATTGACTTAT	0.353		NaN											0	0	0	0.001168	0	4	55									
MRPS22	56945	broad.mit.edu	37	3	139063001	139063001	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:139063001G>C	uc003etb.2	+	1	141	c.133G>C	c.(133-135)GAG>CAG	p.E45Q	MRPS22_uc003etc.2_RNA|MRPS22_uc003etd.2_Missense_Mutation_p.E45Q|MRPS22_uc003ete.2_5'Flank	NM_020191	NP_064576	P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	45						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(2)|skin(1)	3						TTGCTCTTTCGAGATGGGGCT	0.627		NaN											0	0	0	0.001168	0	6	23									
COPB2	9276	broad.mit.edu	37	3	139092111	139092111	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:139092111C>T	uc003etf.3	-	9	1168	c.1038G>A	c.(1036-1038)AAG>AAA	p.K346K	COPB2_uc011bmv.1_Silent_p.K317K|COPB2_uc010hui.2_Silent_p.K317K	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	346					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						TGCCCATATCCTTTACTGCCA	0.438		NaN											0	0	0	0.004482	0	7	104									
SPSB4	92369	broad.mit.edu	37	3	140785627	140785627	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:140785627C>G	uc003ett.2	+	2	935	c.681C>G	c.(679-681)ATC>ATG	p.I227M	SPSB4_uc010hum.2_Missense_Mutation_p.I227M	NM_080862	NP_543138	Q96A44	SPSB4_HUMAN	splA/ryanodine receptor domain and SOCS box	227	B30.2/SPRY.				intracellular signal transduction	cytoplasm	protein binding				0						TGCGCTACATCAACGGCCTTG	0.637		NaN											0	0	0	0.008871	0	14	37									
ATR	545	broad.mit.edu	37	3	142168301	142168301	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:142168301C>G	uc003eux.3	-	47	8027	c.7905G>C	c.(7903-7905)CAG>CAC	p.Q2635H	XRN1_uc003eus.2_5'Flank|XRN1_uc003eut.2_5'Flank|XRN1_uc003euu.2_5'Flank|XRN1_uc003euw.2_5'Flank|XRN1_uc011bnh.1_5'Flank|ATR_uc003euy.1_3'UTR	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2635	FATC.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CAAGATACATCTGGCATAGTA	0.333		NaN						Other_conserved_DNA_damage_response_genes					0	0	0	0.00245	0	12	72									
P2RY13	53829	broad.mit.edu	37	3	151046539	151046539	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:151046539G>C	uc003eyv.2	-	2	326	c.305C>G	c.(304-306)TCT>TGT	p.S102C	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_176894	NP_795713	Q9BPV8	P2Y13_HUMAN	purinergic receptor P2Y, G-protein coupled, 13	102	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(3)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0189)|Lung(72;0.0278)			GTGTGAGTCAGAGAGGATTTT	0.468		NaN											0	0	0	0.001882	0	21	36									
IGSF10	285313	broad.mit.edu	37	3	151154669	151154669	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:151154669G>A	uc011bod.1	-	6	7680	c.7680C>T	c.(7678-7680)ATC>ATT	p.I2560I	IGSF10_uc011bob.1_Silent_p.I587I|IGSF10_uc011boc.1_Silent_p.I539I	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2560	Ig-like C2-type 12.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCTCCCATGTGATTTCTGGCT	0.522		NaN											0	0	0	0.00245	0	15	57									
MME	4311	broad.mit.edu	37	3	154834674	154834674	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:154834674G>A	uc010hvr.1	+	7	764	c.553G>A	c.(553-555)GAA>AAA	p.E185K	MME_uc003fab.1_Missense_Mutation_p.E185K|MME_uc003fac.1_Missense_Mutation_p.E185K|MME_uc003fad.1_Missense_Mutation_p.E185K|MME_uc003fae.1_Missense_Mutation_p.E185K	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	185	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	TTGGACAGCTGAAAAAGCTAT	0.284		NaN											0	0	0	0.001368	0	12	35									
GMPS	8833	broad.mit.edu	37	3	155633963	155633963	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:155633963C>T	uc003faq.2	+	9	1529	c.1194C>T	c.(1192-1194)ATC>ATT	p.I398I	GMPS_uc011bom.1_Silent_p.I299I	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	398					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CAGAGCTCATCAGAAAGTTGA	0.393		NaN	T	MLL	AML								0	0	0	0.007835	0	36	84									
SI	6476	broad.mit.edu	37	3	164735823	164735823	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:164735823T>C	uc003fei.2	-	29	3517	c.3455A>G	c.(3454-3456)TAT>TGT	p.Y1152C		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1152	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AGCCATGTAATAGGGATGAAA	0.313		NaN								HNSCC(35;0.089)			0	0	0	0.004482	0	7	64									
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.001523	0	20	57									
MCCC1	56922	broad.mit.edu	37	3	182763328	182763328	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:182763328C>T	uc003fle.2	-	10	1093	c.956G>A	c.(955-957)GGG>GAG	p.G319E	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Missense_Mutation_p.G202E|MCCC1_uc003flg.2_Missense_Mutation_p.G210E|MCCC1_uc011bqp.1_Missense_Mutation_p.G272E|MCCC1_uc011bqq.1_Missense_Mutation_p.G210E	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	319	Biotin carboxylation.|ATP-grasp.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	CTCCACAGTCCCTAAAAGGTA	0.363		NaN											0	0	0	0.001368	0	13	54									
MCF2L2	23101	broad.mit.edu	37	3	182923668	182923668	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:182923668G>C	uc003fli.1	-	25	2970	c.2880C>G	c.(2878-2880)ATC>ATG	p.I960M		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	960					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			ACCTACCTTTGATATTATTTT	0.368		NaN											0	0	0	0.001368	0	10	21									
KLHL6	89857	broad.mit.edu	37	3	183225916	183225916	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:183225916G>A	uc003flr.2	-	3	898	c.840C>T	c.(838-840)CTC>CTT	p.L280L	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Silent_p.L278L	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	280										haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			ACTGCCTGATGAGAGGATCTG	0.527		NaN											0	0	0	0.005443	0	28	66									
ECE2	9718	broad.mit.edu	37	3	183967544	183967544	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:183967544G>T	uc003fni.3	+	1	100	c.62G>T	c.(61-63)CGC>CTC	p.R21L	ALG3_uc003fne.2_5'Flank|ALG3_uc011brc.1_5'Flank|ALG3_uc011brd.1_5'Flank|ALG3_uc011bre.1_5'Flank|ALG3_uc003fnf.1_5'Flank|ALG3_uc011brf.1_5'Flank|ECE2_uc003fnh.3_Missense_Mutation_p.R21L	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	21	Cytoplasmic (Potential).|Methyltransferase-like region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGCGGGTACCGCGAAGTCGAG	0.667		NaN									OREG0015944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	0.00307968	0.00308	0.00364399	8	56									
C3orf70	285382	broad.mit.edu	37	3	184870595	184870595	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:184870595G>C	uc003fpd.2	-	1	208	c.17C>G	c.(16-18)TCG>TGG	p.S6W		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	6											0						CGACGCCGGCGAGGCCGCCGC	0.716		NaN											0	0	0	0.000248	0	3	14									
DGKG	1608	broad.mit.edu	37	3	185879433	185879433	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:185879433T>C	uc003fqa.2	-	24	2773	c.2236A>G	c.(2236-2238)ATG>GTG	p.M746V	DGKG_uc003fqb.2_Missense_Mutation_p.M707V|DGKG_uc003fqc.2_Missense_Mutation_p.M721V|DGKG_uc011brx.1_Missense_Mutation_p.M687V	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	746					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	TCCACTTGCATTGGCAGCAGC	0.483		NaN											0	0	0	0.006214	0	8	65									
ACAP2	23527	broad.mit.edu	37	3	195102746	195102746	+	Silent	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:195102746C>A	uc003fun.3	-	3	358	c.117G>T	c.(115-117)GTG>GTT	p.V39V	ACAP2_uc003fuo.2_Silent_p.V39V	NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	39	BAR.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						TACAAAGTTTCACAAGCTGAA	0.338		NaN											1	0	1.15088e-07	0.004007	1.39853e-07	13	24									
IQCG	84223	broad.mit.edu	37	3	197652962	197652962	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:197652962C>T	uc003fyo.2	-	6	805	c.659G>A	c.(658-660)AGA>AAA	p.R220K	IQCG_uc003fyn.2_Missense_Mutation_p.R122K|IQCG_uc003fyp.2_Missense_Mutation_p.R220K|IQCG_uc003fyq.3_Missense_Mutation_p.R220K	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	220											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		TATCTGTTTTCTTCCTTTTTC	0.244		NaN											0	0	0	0.002299	0	24	43									
IQCG	84223	broad.mit.edu	37	3	197652965	197652965	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:197652965C>T	uc003fyo.2	-	6	802	c.656G>A	c.(655-657)GGA>GAA	p.G219E	IQCG_uc003fyn.2_Missense_Mutation_p.G121E|IQCG_uc003fyp.2_Missense_Mutation_p.G219E|IQCG_uc003fyq.3_Missense_Mutation_p.G219E	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	219											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		CTGTTTTCTTCCTTTTTCCTC	0.234		NaN											0	0	0	0.008871	0	21	41									
FGFR3	2261	broad.mit.edu	37	4	1806119	1806119	+	Missense_Mutation	SNP	G	G	A	rs28931614		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:1806119G>A	uc003gdr.3	+	9	1394	c.1138G>A	c.(1138-1140)GGG>AGG	p.G380R	FGFR3_uc003gdu.2_Missense_Mutation_p.G382R|FGFR3_uc003gds.3_Intron|FGFR3_uc003gdq.3_Missense_Mutation_p.G380R	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	380	Helical; (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.G380R(15)|p.G380E(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CCTCAGCTACGGGGTGGGCTT	0.672		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.00361	0	167	154									
ADRA2C	152	broad.mit.edu	37	4	3769370	3769370	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:3769370C>G	uc003ghm.2	+	1	1075	c.1037C>G	c.(1036-1038)TCG>TGG	p.S346W	ADRA2C_uc010icx.2_Intron	NM_000683	NP_000674	P18825	ADA2C_HUMAN	alpha-2C-adrenergic receptor	346	Cytoplasmic (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	GGCCGCCTGTCGCGCGCCAGC	0.607		NaN											0	0	0	0.001168	0	5	2									
CLNK	116449	broad.mit.edu	37	4	10566338	10566338	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:10566338G>A	uc003gmo.3	-	7	493	c.356C>T	c.(355-357)TCC>TTC	p.S119F	CLNK_uc003gmp.2_Missense_Mutation_p.S77F	NM_052964	NP_443196	Q7Z7G1	CLNK_HUMAN	mast cell immunoreceptor signal transducer	119					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			ovary(1)	1						CTGTCCAATGGAGATAGAGGT	0.453		NaN											0	0	0	0.002852	0	37	42									
PGM2	55276	broad.mit.edu	37	4	37839181	37839181	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:37839181C>T	uc011byb.1	+	4	460	c.387C>T	c.(385-387)ATC>ATT	p.I129I	PGM2_uc011bya.1_5'UTR|PGM2_uc011byc.1_Intron	NM_018290	NP_060760	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	129					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			ovary(1)	1						CCACATTTATCAGTCAGGGGA	0.458		NaN											0	0	0	0.00361	0	49	128									
SGCB	6443	broad.mit.edu	37	4	52894145	52894145	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:52894145C>G	uc003gzj.2	-	5	802	c.742G>C	c.(742-744)GAG>CAG	p.E248Q	SGCB_uc011bzp.1_Missense_Mutation_p.E178Q	NM_000232	NP_000223	Q16585	SGCB_HUMAN	sarcoglycan, beta	248	Extracellular (Potential).|Cys-rich.				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma					0			GBM - Glioblastoma multiforme(4;7.63e-12)|LUSC - Lung squamous cell carcinoma(32;0.00204)			GCCTTTAACTCCATATTACCA	0.289		NaN											0	0	0	0.007413	0	18	90									
SRD5A3	79644	broad.mit.edu	37	4	56236183	56236183	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:56236183C>T	uc003hau.2	+	5	977	c.882C>T	c.(880-882)CTC>CTT	p.L294L	uc003hav.1_Intron|uc003haw.1_Intron	NM_024592	NP_078868	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	294	Cytoplasmic (Potential).				androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			CTGCCTTTCTCAGCCACCAAT	0.423		NaN											0	0	0	0.004656	0	26	86									
LPHN3	23284	broad.mit.edu	37	4	62542622	62542622	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:62542622C>T	uc010ihh.2	+	3	521	c.348C>T	c.(346-348)TAC>TAT	p.Y116Y	LPHN3_uc003hcq.3_Silent_p.Y116Y|LPHN3_uc010ihg.1_Silent_p.Y184Y	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	116	SUEL-type lectin.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CCTATAAATACCTTGAAGTGC	0.398		NaN											0	0	0	0.001368	0	12	274									
SMR3A	26952	broad.mit.edu	37	4	71232530	71232530	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:71232530G>A	uc003hfg.1	+	3	305	c.224G>A	c.(223-225)AGA>AAA	p.R75K	SMR3B_uc011cas.1_Intron	NM_012390	NP_036522	Q99954	SMR3A_HUMAN	submaxillary gland androgen regulated protein 3	75	Pro-rich.					extracellular region					0		all_hematologic(202;0.196)				GGTCCAGGGAGAATCCCACCA	0.537		NaN											0	0	0	0.007291	0	27	173									
SHROOM3	57619	broad.mit.edu	37	4	77357273	77357273	+	Missense_Mutation	SNP	G	G	A	rs142735873		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:77357273G>A	uc011cbx.1	+	1	1021	c.68G>A	c.(67-69)GGA>GAA	p.G23E		NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	23					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GCCACCAAGGGAAGGTACATT	0.473		NaN											0	0	0	0.00361	0	54	143									
SHROOM3	57619	broad.mit.edu	37	4	77651964	77651964	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:77651964G>A	uc011cbx.1	+	4	1416	c.463G>A	c.(463-465)GAG>AAG	p.E155K	SHROOM3_uc011cbz.1_5'UTR|SHROOM3_uc003hkf.1_Missense_Mutation_p.E30K	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	155					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			CAGGCGCAGTGAGCCTGCAGG	0.562		NaN											0	0	0	0.00361	0	48	87									
SPARCL1	8404	broad.mit.edu	37	4	88401595	88401595	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:88401595C>G	uc010ikm.2	-	10	2318	c.1746G>C	c.(1744-1746)AAG>AAC	p.K582N	SPARCL1_uc011cdc.1_Missense_Mutation_p.K457N|SPARCL1_uc003hqs.3_Missense_Mutation_p.K582N|SPARCL1_uc011cdd.1_Missense_Mutation_p.K457N	NM_001128310	NP_001121782	Q14515	SPRL1_HUMAN	SPARC-like 1 precursor	582					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		GGTAGTTTTTCTTAAAGTCCC	0.423		NaN											0	0	0	0.001786	0	27	81									
PKD2	5311	broad.mit.edu	37	4	88996667	88996667	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:88996667C>A	uc003hre.2	+	15	2794	c.2728C>A	c.(2728-2730)CGT>AGT	p.R910S	PKD2_uc011cdf.1_Missense_Mutation_p.R328S|PKD2_uc011cdg.1_Missense_Mutation_p.R236S|PKD2_uc011cdh.1_Missense_Mutation_p.R133S	NM_000297	NP_000288	Q13563	PKD2_HUMAN	polycystin 2	910	Potential.|C-terminal coiled coil domain.|Cytoplasmic (Potential).					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		ACGGCTAGTACGTGAAGAGTT	0.507		NaN											1	0	2.61193e-14	0.001786	3.27344e-14	33	256									
FAM13A	10144	broad.mit.edu	37	4	89709016	89709016	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:89709016G>T	uc003hse.1	-	10	1367	c.1159C>A	c.(1159-1161)CAA>AAA	p.Q387K	FAM13A_uc003hsb.1_Missense_Mutation_p.Q61K|FAM13A_uc003hsd.1_Missense_Mutation_p.Q61K|FAM13A_uc003hsc.1_Missense_Mutation_p.Q47K|FAM13A_uc011cdq.1_Missense_Mutation_p.Q33K|FAM13A_uc003hsf.1_Intron|FAM13A_uc003hsg.1_5'UTR|FAM13A_uc003hsh.1_Missense_Mutation_p.Q201K|FAM13A_uc010ikr.1_5'UTR	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	387					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						TCTGAACTTTGACCTCCAGAG	0.463		NaN											1	0	1.05317e-09	0.00245	1.29843e-09	13	94									
TIGD2	166815	broad.mit.edu	37	4	90034378	90034378	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:90034378G>C	uc003hsk.2	+	1	411	c.253G>C	c.(253-255)GAG>CAG	p.E85Q	FAM13A_uc003hsh.1_5'Flank	NM_145715	NP_663761	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	85	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		AGTTATGATAGAGTGGTTTAA	0.393		NaN											0	0	0	0.006122	0	15	65									
MTTP	4547	broad.mit.edu	37	4	100503108	100503108	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:100503108C>G	uc003hvc.3	+	3	364	c.108C>G	c.(106-108)CTC>CTG	p.L36L	MTTP_uc011cej.1_Silent_p.L63L|MTTP_uc003hvb.2_Silent_p.L36L	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	36	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	TGTACAAGCTCACGTACTCCA	0.458		NaN											0	0	0	0.00499	0	17	79									
CENPE	1062	broad.mit.edu	37	4	104079969	104079969	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:104079969C>T	uc003hxb.1	-	23	2766	c.2676G>A	c.(2674-2676)CTG>CTA	p.L892L	CENPE_uc003hxc.1_Silent_p.L867L	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	892	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		ATTGTTCCTTCAGCTGTTCCA	0.348		NaN											0	0	0	0.001882	0	22	49									
KIAA1109	84162	broad.mit.edu	37	4	123270446	123270446	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:123270446G>T	uc003ieh.2	+	76	13459	c.13414G>T	c.(13414-13416)GAT>TAT	p.D4472Y	KIAA1109_uc003iem.2_Missense_Mutation_p.D828Y	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4472					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGGGACCATAGATGTCAATGC	0.368		NaN											1	0	2.4624e-09	0.008871	3.02032e-09	19	27									
PGRMC2	10424	broad.mit.edu	37	4	129193566	129193566	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:129193566C>G	uc003igg.2	-	2	530	c.525G>C	c.(523-525)TTG>TTC	p.L175F		NM_006320	NP_006311			progesterone receptor membrane component 2												0						GTACTGCATTCAAATCTGAGA	0.353		NaN											0	0	0	0.001984	0	5	39									
PGRMC2	10424	broad.mit.edu	37	4	129193594	129193594	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:129193594C>G	uc003igg.2	-	2	502	c.497G>C	c.(496-498)AGA>ACA	p.R166T		NM_006320	NP_006311			progesterone receptor membrane component 2												0						ATATTCATCTCTAAGTGCATC	0.373		NaN											0	0	0	0.001168	0	5	33									
MAML3	55534	broad.mit.edu	37	4	140641044	140641044	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:140641044C>G	uc003ihz.1	-	7	3587	c.2835G>C	c.(2833-2835)CAG>CAC	p.Q945H	MGST2_uc010ioi.1_Intron|MAML3_uc011chd.1_Missense_Mutation_p.Q413H	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	946	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					CCATAAGGCTCTGCAGCCTTG	0.567		NaN											0	0	0	0.002522	0	42	96									
TBC1D9	23158	broad.mit.edu	37	4	141555214	141555214	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:141555214G>C	uc010ioj.2	-	16	2906	c.2634C>G	c.(2632-2634)CTC>CTG	p.L878L		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	878						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CCCAAGGAAAGAGAAGAGCAA	0.522		NaN											0	0	0	0.00308	0	8	32									
LRBA	987	broad.mit.edu	37	4	151511949	151511949	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:151511949G>C	uc010ipj.2	-	40	6616	c.6142C>G	c.(6142-6144)CAG>GAG	p.Q2048E	LRBA_uc003ilt.3_Missense_Mutation_p.Q696E|LRBA_uc003ilu.3_Missense_Mutation_p.Q2037E	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2048						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TCTGAGTTCTGATTTCCTAAA	0.428		NaN											0	0	0	0.00874	0	40	45									
GUCY1A3	2982	broad.mit.edu	37	4	156632044	156632044	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:156632044G>C	uc003iov.2	+	7	1263	c.727G>C	c.(727-729)GAT>CAT	p.D243H	GUCY1A3_uc003iou.2_Missense_Mutation_p.D243H|GUCY1A3_uc010iqc.2_Missense_Mutation_p.D243H|GUCY1A3_uc003iow.2_Missense_Mutation_p.D243H|GUCY1A3_uc010iqd.2_Missense_Mutation_p.D242H|GUCY1A3_uc003iox.2_Missense_Mutation_p.D243H|GUCY1A3_uc003ioz.2_Missense_Mutation_p.D8H|GUCY1A3_uc003ioy.2_Missense_Mutation_p.D243H|GUCY1A3_uc010iqe.2_Missense_Mutation_p.D8H|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Missense_Mutation_p.D243H	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	243					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CTTCCATAATGATTGCAGCGA	0.502		NaN											0	0	0	0.002836	0	32	103									
RAPGEF2	9693	broad.mit.edu	37	4	160244633	160244633	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:160244633T>G	uc003iqg.3	+	5	840	c.530T>G	c.(529-531)CTC>CGC	p.L177R		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	177	cNMP.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TCAGTGATTCTCAATGGATCT	0.398		NaN											0	0	0	0.00333	0	22	46									
SC4MOL	6307	broad.mit.edu	37	4	166254535	166254535	+	Missense_Mutation	SNP	G	G	A	rs146748626	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:166254535G>A	uc003ire.2	+	2	143	c.13G>A	c.(13-15)GAA>AAA	p.E5K	SC4MOL_uc010irb.2_Missense_Mutation_p.E5K|SC4MOL_uc003irf.2_Intron	NM_006745	NP_006736	Q15800	ERG25_HUMAN	sterol-C4-methyl oxidase-like isoform 1	5					cholesterol biosynthetic process|fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	C-4 methylsterol oxidase activity|iron ion binding				0	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0875)	NADH(DB00157)	GGCAACAAATGAAAGTGTCAG	0.323		NaN											0	0	0	0.00333	0	21	56									
SC4MOL	6307	broad.mit.edu	37	4	166258996	166258996	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:166258996A>T	uc003ire.2	+	3	441	c.311A>T	c.(310-312)AAT>ATT	p.N104I	SC4MOL_uc010irb.2_Missense_Mutation_p.N104I|SC4MOL_uc003irf.2_5'UTR	NM_006745	NP_006736	Q15800	ERG25_HUMAN	sterol-C4-methyl oxidase-like isoform 1	104	Helical; (Potential).				cholesterol biosynthetic process|fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	C-4 methylsterol oxidase activity|iron ion binding				0	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0875)	NADH(DB00157)	CTTCTCTTTAATCACTTCTGT	0.353		NaN											0	0	0	0.001523	0	21	48									
SNX25	83891	broad.mit.edu	37	4	186244769	186244769	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:186244769G>C	uc003ixh.2	+	9	1261	c.1072G>C	c.(1072-1074)GAA>CAA	p.E358Q	SNX25_uc010ish.2_Missense_Mutation_p.E129Q|SNX25_uc003ixi.2_5'UTR	NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	358	RGS.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		ACTTTACAAAGAAATTCAGCA	0.328		NaN											0	0	0	0.008871	0	20	31									
CCDC110	256309	broad.mit.edu	37	4	186392204	186392204	+	Splice_Site	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:186392204C>T	uc003ixu.3	-	2	87	c.11_splice	c.e2-1	p.E4_splice	CCDC110_uc003ixv.3_Splice_Site_p.E4_splice|CCDC110_uc011ckt.1_Splice_Site_p.E4_splice	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a							nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TGCTGCTTTTCTGTAACAGAA	0.458		NaN											0	0	0	0.002222	0	42	74									
KLKB1	3818	broad.mit.edu	37	4	187173013	187173013	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:187173013C>G	uc003iyy.2	+	10	1213	c.1142C>G	c.(1141-1143)TCT>TGT	p.S381C	KLKB1_uc011clc.1_Missense_Mutation_p.S179C|KLKB1_uc011cld.1_Missense_Mutation_p.S343C	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	381					blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GGGGACAACTCTGGTGAGTAA	0.423		NaN											0	0	0	0.001523	0	20	109									
FAT1	2195	broad.mit.edu	37	4	187521209	187521209	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:187521209C>G	uc003izf.2	-	22	12134	c.11946G>C	c.(11944-11946)TTG>TTC	p.L3982F	FAT1_uc003ize.2_5'Flank	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3982	Extracellular (Potential).|Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CCTGCCCATTCAAATAAATGG	0.498		NaN								HNSCC(5;0.00058)			0	0	0	0.00361	0	60	114									
FAT1	2195	broad.mit.edu	37	4	187531098	187531098	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:187531098C>T	uc003izf.2	-	15	10113	c.9925G>A	c.(9925-9927)GAT>AAT	p.D3309N		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3309	Extracellular (Potential).|Cadherin 30.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTGCCTCCATCAGTGGCCTCT	0.443		NaN								HNSCC(5;0.00058)			0	0	0	0.008291	0	10	43									
PLEKHG4B	153478	broad.mit.edu	37	5	174135	174135	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:174135G>C	uc003jak.2	+	16	3306	c.3256G>C	c.(3256-3258)GCA>CCA	p.A1086P		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	1086	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CATTCTCCAAGCAAGCTCGGC	0.582		NaN											0	0	0	0.004482	0	9	11									
PLEKHG4B	153478	broad.mit.edu	37	5	174155	174155	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:174155G>C	uc003jak.2	+	16	3326	c.3276G>C	c.(3274-3276)AAG>AAC	p.K1092N		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	1092	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CAGAGGTCAAGAGTGCATGGA	0.592		NaN											0	0	0	0.001168	0	6	7									
SLC6A3	6531	broad.mit.edu	37	5	1414876	1414876	+	Missense_Mutation	SNP	G	G	C	rs28363072		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:1414876G>C	uc003jck.2	-	8	1207	c.1086C>G	c.(1084-1086)TTC>TTG	p.F362L		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	362	Helical; Name=7; (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AGAAGACGACGAAGCCGGAGG	0.617		NaN											0	0	0	0.00499	0	14	62									
KIAA0947	23379	broad.mit.edu	37	5	5464123	5464123	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:5464123C>T	uc003jdm.3	+	13	4898	c.4676C>T	c.(4675-4677)TCA>TTA	p.S1559L		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1559										ovary(1)|central_nervous_system(1)	2						TCAAAGATTTCAAACAAAGAT	0.373		NaN											0	0	0	0.00308	0	8	55									
NSUN2	54888	broad.mit.edu	37	5	6620355	6620355	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:6620355G>C	uc003jdu.2	-	7	744	c.679C>G	c.(679-681)CAA>GAA	p.Q227E	NSUN2_uc003jdt.2_Translation_Start_Site|NSUN2_uc011cmk.1_Missense_Mutation_p.Q192E|NSUN2_uc003jdv.2_Translation_Start_Site	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	227						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						CTCTTGGCTTGATGGACGAGC	0.522		NaN											0	0	0	0.00623	0	37	114									
ADCY2	108	broad.mit.edu	37	5	7789838	7789838	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:7789838G>A	uc003jdz.1	+	20	2620	c.2553G>A	c.(2551-2553)CTG>CTA	p.L851L	ADCY2_uc011cmo.1_Silent_p.L671L|ADCY2_uc010itm.1_Silent_p.L47L	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	851	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TGGAGAACCTGAACCGCGTGC	0.527		NaN											0	0	0	0.002096	0	33	83									
FASTKD3	79072	broad.mit.edu	37	5	7861360	7861360	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:7861360C>G	uc003jeb.2	-	6	1923	c.1786G>C	c.(1786-1788)GAT>CAT	p.D596H	FASTKD3_uc011cmp.1_Missense_Mutation_p.D298H|FASTKD3_uc003jec.2_RNA	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	596	RAP.				apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						TTTGGACCATCAATACACAGT	0.279		NaN											0	0	0	0.00278	0	22	87									
DNAH5	1767	broad.mit.edu	37	5	13862845	13862845	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:13862845G>A	uc003jfd.2	-	29	4650	c.4608C>T	c.(4606-4608)ATC>ATT	p.I1536I		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1536	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCACCGCACTGATACAGATGT	0.413		NaN							Kartagener_syndrome				0	0	0	0.007291	0	26	96									
CDH10	1008	broad.mit.edu	37	5	24505321	24505321	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:24505321G>C	uc003jgr.1	-	8	1625	c.1293C>G	c.(1291-1293)ATC>ATG	p.I431M	CDH10_uc011cnu.1_Intron	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	431	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GAATGTTAAAGATTCTGTCAA	0.363		NaN								HNSCC(23;0.051)			0	0	0	0.006214	0	10	34									
PDZD2	23037	broad.mit.edu	37	5	32087406	32087406	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:32087406C>T	uc003jhl.2	+	20	4240	c.3852C>T	c.(3850-3852)CTC>CTT	p.L1284L	PDZD2_uc003jhm.2_Silent_p.L1284L	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1284					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CAGTCAGGCTCCCCCATGAGG	0.622		NaN											0	0	0	0.004878	0	34	100									
NIPBL	25836	broad.mit.edu	37	5	37064931	37064931	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:37064931G>A	uc003jkl.3	+	47	8851	c.8352G>A	c.(8350-8352)CTG>CTA	p.L2784L	NIPBL_uc003jkk.3_3'UTR|NIPBL_uc003jkn.2_3'UTR	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2784					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CTAATAAGCTGACTAATAAAG	0.408		NaN											0	0	0	0.002299	0	23	61									
ITGA2	3673	broad.mit.edu	37	5	52371064	52371064	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:52371064G>A	uc003joy.2	+	23	2898	c.2755G>A	c.(2755-2757)GAA>AAA	p.E919K	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.E843K|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	919	Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AAGCCAAGAAGAAAACAAGGC	0.348		NaN											0	0	0	0.003163	0	15	45									
GZMA	3001	broad.mit.edu	37	5	54398580	54398580	+	Missense_Mutation	SNP	G	G	C	rs142297007	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:54398580G>C	uc003jpm.2	+	1	107	c.70G>C	c.(70-72)GAT>CAT	p.D24H		NM_006144	NP_006135	P12544	GRAA_HUMAN	granzyme A precursor	24					cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				AATTCCTGAAGGTAAGACTGA	0.408		NaN											0	0	0	0.001523	0	21	81									
DHX29	54505	broad.mit.edu	37	5	54567922	54567922	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:54567922C>G	uc003jpx.2	-	18	2977	c.2857G>C	c.(2857-2859)GAA>CAA	p.E953Q	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	953	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TACTTATTTTCTTTTGTTCTT	0.318		NaN											0	0	0	0.002522	0	45	31									
DHX29	54505	broad.mit.edu	37	5	54585110	54585110	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:54585110C>T	uc003jpx.2	-	8	1174	c.1054G>A	c.(1054-1056)GAA>AAA	p.E352K	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	352							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TTCTCTTCTTCAGTAGCAGCT	0.313		NaN											0	0	0	0.000978	0	11	86									
SLC38A9	153129	broad.mit.edu	37	5	54922343	54922343	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:54922343C>G	uc003jqf.2	-	16	1866	c.1665G>C	c.(1663-1665)CTG>CTC	p.L555L	SLC38A9_uc003jqd.2_Silent_p.L492L|SLC38A9_uc010ivx.2_Silent_p.L492L|SLC38A9_uc003jqe.2_RNA|SLC38A9_uc010ivy.2_Silent_p.L426L	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	555	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				ACTGAACAATCAGGTTAGCCA	0.358		NaN											0	0	0	0.00361	0	85	90									
ERBB2IP	55914	broad.mit.edu	37	5	65349978	65349978	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:65349978C>T	uc003juk.1	+	21	3140	c.2832C>T	c.(2830-2832)TTC>TTT	p.F944F	ERBB2IP_uc003jui.1_Silent_p.F944F|ERBB2IP_uc003juj.1_Silent_p.F944F|ERBB2IP_uc011cqx.1_Silent_p.F944F|ERBB2IP_uc011cqy.1_Silent_p.F944F|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Silent_p.F940F|ERBB2IP_uc003jul.1_Silent_p.F940F	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	944					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		AGGCAATTTTCAAGTTTGATT	0.403		NaN											0	0	0	0.008291	0	11	69									
BDP1	55814	broad.mit.edu	37	5	70751838	70751838	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:70751838C>T	uc003kbp.1	+	1	397	c.134C>T	c.(133-135)TCC>TTC	p.S45F	BDP1_uc003kbn.1_Missense_Mutation_p.S45F|BDP1_uc003kbo.2_Missense_Mutation_p.S45F	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	45	Interaction with ZBTB43.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GACTCTGCTTCCAAGCCCGCG	0.632		NaN											0	0	0	0.00245	0	12	34									
BDP1	55814	broad.mit.edu	37	5	70805391	70805391	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:70805391G>T	uc003kbp.1	+	17	2735	c.2472G>T	c.(2470-2472)AGG>AGT	p.R824S	BDP1_uc003kbn.1_Missense_Mutation_p.R824S|BDP1_uc003kbo.2_Missense_Mutation_p.R824S	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	824	9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N- G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R- E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X- D-L-E-E-T.|1; approximate.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GAACTGGAAGGAGAGAAATTT	0.413		NaN											1	0	6.72482e-11	0.003163	8.35526e-11	14	106									
HEXB	3074	broad.mit.edu	37	5	73981280	73981280	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:73981280G>A	uc003kdf.3	+	1	312	c.195G>A	c.(193-195)ATG>ATA	p.M65I	HEXB_uc003kdd.2_Intron|HEXB_uc003kde.2_Missense_Mutation_p.M65I|HEXB_uc010izh.2_RNA	NM_000521	NP_000512	P07686	HEXB_HUMAN	hexosaminidase B preproprotein	65					cell death	lysosome	cation binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.72e-57)		TGGTGAAGATGACCCCGAACC	0.697		NaN											0	0	0	0.008291	0	10	20									
SV2C	22987	broad.mit.edu	37	5	75621207	75621207	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:75621207C>G	uc003kei.1	+	13	2153	c.2019C>G	c.(2017-2019)TTC>TTG	p.F673L		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	673	Helical; (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		GCTTTGGCTTCTTAAATGCGC	0.463		NaN											0	0	0	0.00632	0	26	71									
ZCCHC9	84240	broad.mit.edu	37	5	80604427	80604427	+	Silent	SNP	C	C	T	rs149561750	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:80604427C>T	uc003khj.2	+	3	565	c.432C>T	c.(430-432)CCC>CCT	p.P144P	RNU5E_uc011cto.1_Intron|ZCCHC9_uc003khk.3_Silent_p.P144P|ZCCHC9_uc003khi.2_Silent_p.P144P	NM_001131035	NP_001124507	Q8N567	ZCHC9_HUMAN	zinc finger, CCHC domain containing 9	144	CCHC-type 1.						nucleic acid binding|zinc ion binding			ovary(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;8.18e-45)|Epithelial(54;2.72e-39)|all cancers(79;7.33e-34)		CAGATTGCCCCGCCGCCCTTG	0.473		NaN											0	0	0	0.001523	0	20	51									
VCAN	1462	broad.mit.edu	37	5	82850806	82850806	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:82850806C>T	uc003kii.3	+	12	10040	c.9684C>T	c.(9682-9684)CTC>CTT	p.L3228L	VCAN_uc003kij.3_Silent_p.L2241L|VCAN_uc010jau.2_Silent_p.L1474L|VCAN_uc003kik.3_Silent_p.L487L|VCAN_uc003kil.3_Silent_p.L1892L	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	3228	C-type lectin.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GGATAGGCCTCAATGACAAGA	0.403		NaN											0	0	0	0.00333	0	23	62									
RASA1	5921	broad.mit.edu	37	5	86564633	86564633	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:86564633C>T	uc003kiw.2	+	1	483	c.365C>T	c.(364-366)TCG>TTG	p.S122L	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_5'Flank|RASA1_uc011ctv.1_5'Flank|RASA1_uc011ctw.1_5'Flank|RASA1_uc010jaw.2_5'Flank|RASA1_uc011ctu.1_Missense_Mutation_p.S122L	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	122					cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		CTGCCCACTTCGTTGCTTGCT	0.473		NaN											0	0	0	0.004482	0	6	27									
FBXL17	64839	broad.mit.edu	37	5	107521822	107521822	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:107521822C>T	uc011cvc.1	-	6	2148	c.1741G>A	c.(1741-1743)GAC>AAC	p.D581N	FBXL17_uc003kon.3_Missense_Mutation_p.D183N	NM_001163315	NP_001156787	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	581											0		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		GGTTACCTGTCATTTATGATC	0.313		NaN											0	0	0	0.001984	0	6	45									
ZNF608	57507	broad.mit.edu	37	5	123983433	123983433	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:123983433C>T	uc003ktq.1	-	4	2767	c.2644G>A	c.(2644-2646)GAG>AAG	p.E882K	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Missense_Mutation_p.E882K|ZNF608_uc003ktt.1_Missense_Mutation_p.E882K	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	882						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TTATCGGCCTCAGCTTTGATA	0.527		NaN											0	0	0	0.00245	0	14	87									
C5orf56	441108	broad.mit.edu	37	5	131796262	131796262	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:131796262C>G	uc003kwy.1	+	4	228	c.97C>G	c.(97-99)CAA>GAA	p.Q33E	C5orf56_uc003kwz.1_Intron|C5orf56_uc010jds.1_Intron|IRF1_uc003kxd.2_Intron	NM_001013717	NP_001013739	Q8N8D9	CE056_HUMAN	hypothetical protein LOC441108	33											0						agggaatcttcaaactcttct	0.02		NaN											0	0	0	0.003755	0	33	254									
SKP1	6500	broad.mit.edu	37	5	133502935	133502935	+	Splice_Site	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:133502935C>T	uc003kzc.3	-	3	277	c.98_splice	c.e3-1	p.D33_splice	SKP1_uc003kzd.3_Splice_Site_p.D33_splice|SKP1_uc010jdv.2_Splice_Site_p.D33_splice	NM_170679	NP_733779	P63208	SKP1_HUMAN	S-phase kinase-associated protein 1 isoform b						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle|histone H2A monoubiquitination|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATTCCCAAATCTAAGAAAACC	0.299		NaN											0	0	0	0.000978	0	12	69									
HSPA9	3313	broad.mit.edu	37	5	137902369	137902369	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:137902369C>G	uc003ldf.2	-	9	1026	c.918G>C	c.(916-918)CAG>CAC	p.Q306H	HSPA9_uc011cyw.1_Missense_Mutation_p.Q237H	NM_004134	NP_004125	P38646	GRP75_HUMAN	heat shock 70kDa protein 9 precursor	306					anti-apoptosis|protein folding	cell surface|mitochondrial nucleoid	ATP binding|unfolded protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CCCGTACCCTCTGAAGTGCCA	0.438		NaN											0	0	0	0.004656	0	22	185									
SLC35A4	113829	broad.mit.edu	37	5	139947635	139947635	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:139947635C>T	uc003lgg.1	+	3	1609	c.881C>T	c.(880-882)TCA>TTA	p.S294L	SLC35A4_uc003lgh.1_Missense_Mutation_p.S294L	NM_080670	NP_542401	Q96G79	S35A4_HUMAN	solute carrier family 35, member A4	294	Leu-rich.|Helical; (Potential).					Golgi membrane|integral to membrane	sugar:hydrogen symporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGTGCTCTCAGCAGTCCTG	0.592		NaN											0	0	0	0.007413	0	19	49									
PCDHA5	56143	broad.mit.edu	37	5	140202747	140202747	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140202747G>A	uc003lhl.2	+	1	1387	c.1387G>A	c.(1387-1389)GTG>ATG	p.V463M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.V463M|PCDHA5_uc003lhj.1_Missense_Mutation_p.V463M	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	463	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACCGTGTTCGTGAAGGAGAA	0.662		NaN											0	0	0	0.00632	0	28	94									
PCDHA6	56142	broad.mit.edu	37	5	140209836	140209836	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140209836G>A	uc003lho.2	+	1	2187	c.2160G>A	c.(2158-2160)GCG>GCA	p.A720A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.A720A	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	720	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTACACAGCGCTGCGGTGCT	0.677		NaN											0	0	0	0.000978	0	12	79									
PCDHA8	56140	broad.mit.edu	37	5	140222611	140222611	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140222611C>G	uc003lhs.2	+	1	1705	c.1705C>G	c.(1705-1707)CGG>GGG	p.R569G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.R569G	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	569	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGAGCCTCGGGTGGGTGG	0.721		NaN											0	0	0	0.005524	0	36	76									
PCDHA9	9752	broad.mit.edu	37	5	140228108	140228108	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140228108G>C	uc003lhu.2	+	1	752	c.28G>C	c.(28-30)GAG>CAG	p.E10Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.E10Q	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	10					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGAGATCCAGAGGGTCAGCC	0.493		NaN											0	0	0	0.00361	0	50	113									
PCDHA10	56139	broad.mit.edu	37	5	140236081	140236081	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140236081C>G	uc003lhx.2	+	1	448	c.448C>G	c.(448-450)CGA>GGA	p.R150G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.R150G|PCDHA10_uc011dad.1_Missense_Mutation_p.R150G	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	150	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTTGACTCTCGATTTCCACT	0.438		NaN											0	0	0	0.00361	0	66	130									
PCDHB6	56130	broad.mit.edu	37	5	140530815	140530815	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140530815C>T	uc003lir.2	+	1	977	c.977C>T	c.(976-978)TCA>TTA	p.S326L	PCDHB6_uc011dah.1_Missense_Mutation_p.S190L	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	326	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGGCCTATCAGGAAAATGC	0.468		NaN											0	0	0	0.004007	0	17	48									
PCDHB7	56129	broad.mit.edu	37	5	140554506	140554506	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140554506C>T	uc003lit.2	+	1	2264	c.2090C>T	c.(2089-2091)TCG>TTG	p.S697L	PCDHB8_uc011dai.1_5'Flank	NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	697	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGTGTCTTCGCTCTTCCTC	0.706		NaN											0	0	0	0.003755	0	35	375									
PCDHB11	56125	broad.mit.edu	37	5	140580555	140580555	+	Nonsense_Mutation	SNP	T	T	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140580555T>A	uc003liy.2	+	1	1208	c.1208T>A	c.(1207-1209)TTG>TAG	p.L403*	PCDHB11_uc011daj.1_Nonsense_Mutation_p.L38*	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	403	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TACTACACGTTGGAAACAGAG	0.478		NaN											0	0	0	0.001882	0	20	114									
PCDHB13	56123	broad.mit.edu	37	5	140596055	140596055	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140596055C>G	uc003lja.1	+	1	2547	c.2360C>G	c.(2359-2361)TCT>TGT	p.S787C		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	787	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAAGGAAATTCTACCTTCCCC	0.428		NaN											0	0	0	0.003163	0	14	76									
PCDHGA3	56112	broad.mit.edu	37	5	140724723	140724723	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140724723G>C	uc003ljm.1	+	1	1123	c.1123G>C	c.(1123-1125)GAT>CAT	p.D375H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.D135H|PCDHGA3_uc011dap.1_Missense_Mutation_p.D375H	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	375	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCATGACCGAGATTCTGGGCA	0.448		NaN											0	0	0	0.00333	0	23	99									
PCDHGB3	56102	broad.mit.edu	37	5	140750497	140750497	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140750497C>G	uc003ljw.1	+	1	536	c.536C>G	c.(535-537)TCT>TGT	p.S179C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc011dat.1_Missense_Mutation_p.S179C	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	179	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCACTTCTCTTTGATTCAG	0.542		NaN											0	0	0	0.00361	0	92	170									
PCDHGB4	8641	broad.mit.edu	37	5	140769071	140769071	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140769071C>G	uc003lkc.1	+	1	1620	c.1620C>G	c.(1618-1620)CTC>CTG	p.L540L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Silent_p.L540L	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	540	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCAGCGCTCAGCGCGAACG	0.701		NaN											0	0	0	0.001984	0	7	50									
PCDHGB6	56100	broad.mit.edu	37	5	140788139	140788139	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140788139G>A	uc003lkj.1	+	1	370	c.370G>A	c.(370-372)GAG>AAG	p.E124K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.E124K	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	124	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGGTGATTGAGGATGTTAA	0.398		NaN											0	0	0	0.00361	0	47	88									
ARAP3	64411	broad.mit.edu	37	5	141041670	141041670	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:141041670G>A	uc003llm.2	-	20	3031	c.2953C>T	c.(2953-2955)CGT>TGT	p.R985C	ARAP3_uc003lll.2_5'UTR|ARAP3_uc011dbe.1_Missense_Mutation_p.R647C|ARAP3_uc003lln.2_Intron	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	985	Rho-GAP.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						TCGAGCTCACGAAAGAAGCGT	0.592		NaN											0	0	0	0.003954	0	22	103									
GRXCR2	643226	broad.mit.edu	37	5	145252372	145252372	+	Silent	SNP	G	G	A	rs150272088	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:145252372G>A	uc003lns.1	-	1	160	c.160C>T	c.(160-162)CTG>TTG	p.L54L		NM_001080516	NP_001073985	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	54											0						GACTCTTGCAGAAAACTGTGA	0.493		NaN											0	0	0	0.005524	0	40	92									
RBM27	54439	broad.mit.edu	37	5	145641356	145641356	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:145641356G>A	uc003lnz.3	+	13	2343	c.2177G>A	c.(2176-2178)GGA>GAA	p.G726E	RBM27_uc003lny.2_Missense_Mutation_p.G671E	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	726					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACAGTGCACGGAGGTATCCAG	0.478		NaN											0	0	0	0.000978	0	11	39									
ARHGEF37	389337	broad.mit.edu	37	5	149006694	149006694	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:149006694C>G	uc003lra.1	+	11	1584	c.1520C>G	c.(1519-1521)CCT>CGT	p.P507R		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	507	SH3 1.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0						AGGTATGGCCCTGGGAAGCTG	0.577		NaN											0	0	0	0.003954	0	25	146									
TCOF1	6949	broad.mit.edu	37	5	149748414	149748414	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:149748414G>A	uc003lry.2	+	5	622	c.514G>A	c.(514-516)GAA>AAA	p.E172K	TCOF1_uc003lrw.2_Missense_Mutation_p.E172K|TCOF1_uc011dch.1_Missense_Mutation_p.E172K|TCOF1_uc003lrz.2_Missense_Mutation_p.E172K|TCOF1_uc003lrx.2_Missense_Mutation_p.E172K|TCOF1_uc003lsa.2_Missense_Mutation_p.E172K	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	172					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTTGGTCTCAGAAACTGAGGA	0.582		NaN											0	0	0	0.001882	0	21	54									
LARP1	23367	broad.mit.edu	37	5	154173531	154173531	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:154173531G>T	uc003lvp.2	+	6	1469	c.1040G>T	c.(1039-1041)GGC>GTC	p.G347V	LARP1_uc003lvo.2_Missense_Mutation_p.G270V|LARP1_uc010jie.1_Missense_Mutation_p.G142V	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	347							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CGTGGTCGCGGCCGGGGACGC	0.692		NaN											1	0	3.59834e-05	0.001168	4.30724e-05	6	80									
KIF4B	285643	broad.mit.edu	37	5	154393975	154393975	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:154393975G>T	uc010jih.1	+	1	716	c.556G>T	c.(556-558)GAT>TAT	p.D186Y		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	186	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGTTGCCTTGGATACTGTTTC	0.468		NaN											1	0	0.00621372	0.006214	0.00734024	10	224									
TIMD4	91937	broad.mit.edu	37	5	156353320	156353320	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:156353320G>C	uc003lwh.2	-	6	905	c.848C>G	c.(847-849)TCT>TGT	p.S283C	TIMD4_uc010jii.2_Missense_Mutation_p.S255C|TIMD4_uc003lwg.2_Translation_Start_Site	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	283	Extracellular (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGCTGTATCAGATGCTGGGAA	0.358		NaN											0	0	0	0.008291	0	9	31									
GABRA6	2559	broad.mit.edu	37	5	161116300	161116300	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:161116300T>G	uc003lyu.2	+	5	825	c.487T>G	c.(487-489)TTT>GTT	p.F163V	GABRA6_uc003lyv.2_5'Flank	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	163	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GCTGGTTAACTTTCCTATGGA	0.398		NaN								TCGA Ovarian(5;0.080)			0	0	0	0.004656	0	23	89									
SLIT3	6586	broad.mit.edu	37	5	168119694	168119694	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:168119694C>T	uc003mab.2	-	29	3514	c.3094G>A	c.(3094-3096)GAC>AAC	p.D1032N	SLIT3_uc010jjg.2_Missense_Mutation_p.D1039N	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1032	EGF-like 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCACCTCGTCGCATAGCTCA	0.577		NaN											0	0	0	0.004007	0	15	36									
NSD1	64324	broad.mit.edu	37	5	176637917	176637917	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:176637917G>A	uc003mfr.3	+	5	2655	c.2517G>A	c.(2515-2517)CTG>CTA	p.L839L	NSD1_uc003mft.3_Silent_p.L570L|NSD1_uc003mfs.1_Silent_p.L736L|NSD1_uc011dfx.1_Silent_p.L487L	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	839					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TAAAACTACTGAACAATATGC	0.408		NaN	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			0	0	0	0.004007	0	16	52									
PFN3	345456	broad.mit.edu	37	5	176827416	176827416	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:176827416C>T	uc003mgl.2	-	1	222	c.162G>A	c.(160-162)CCG>CCA	p.P54P		NM_001029886	NP_001025057	P60673	PROF3_HUMAN	profilin 3	54					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin binding				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGTGCCTGTCCGGCCCCGTGA	0.746		NaN											0	0	0	0.000248	0	4	5									
COL23A1	91522	broad.mit.edu	37	5	177690292	177690292	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:177690292G>C	uc003mje.2	-	9	914	c.556C>G	c.(556-558)CCG>GCG	p.P186A	COL23A1_uc010jkt.2_Silent_p.L33L	NM_173465	NP_775736	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	186	Extracellular (Potential).|Collagen-like 1.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|skin(1)	2	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		GGGGGCCCCGGAGGCCCAGCA	0.672		NaN											0	0	0	0.001855	0	11	21									
RNF130	55819	broad.mit.edu	37	5	179390562	179390562	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:179390562C>T	uc003mll.1	-	8	1560	c.1153G>A	c.(1153-1155)GAA>AAA	p.E385K	RNF130_uc003mlm.1_Intron	NM_018434	NP_060904	Q86XS8	GOLI_HUMAN	ring finger protein 130 precursor	385	Cytoplasmic (Potential).				apoptosis	cytoplasm|integral to membrane|nucleus	ubiquitin-protein ligase activity|zinc ion binding			lung(2)|ovary(1)	3	all_cancers(89;5.49e-05)|all_epithelial(37;1.94e-05)|Renal(175;0.000159)|Lung NSC(126;0.00118)|all_lung(126;0.00212)	all_cancers(40;0.0294)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATAAACCATTCTTCTGTTGAC	0.448		NaN											0	0	0	0.008291	0	8	11									
GFPT2	9945	broad.mit.edu	37	5	179745840	179745840	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:179745840G>C	uc003mlw.1	-	10	1009	c.911C>G	c.(910-912)TCT>TGT	p.S304C		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	304					dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)|skin(1)	2	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	GATGGCTCGAGATGGGTCATC	0.607		NaN											0	0	0	0.00245	0	14	37									
FLT4	2324	broad.mit.edu	37	5	180041111	180041111	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:180041111G>A	uc003mma.3	-	24	3367	c.3288C>T	c.(3286-3288)GAC>GAT	p.D1096D	FLT4_uc003mlz.3_Silent_p.D1096D	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	1096	Cytoplasmic (Potential).|Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	AGGACCACACGTCACTCTGCG	0.622		NaN							Congenital_Hereditary_Lymphedema				0	0	0	0.003755	0	33	51									
RREB1	6239	broad.mit.edu	37	6	7229506	7229506	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:7229506C>T	uc003mxc.2	+	10	1564	c.1174C>T	c.(1174-1176)CAG>TAG	p.Q392*	RREB1_uc003mxb.2_Nonsense_Mutation_p.Q392*|RREB1_uc010jnx.2_Nonsense_Mutation_p.Q392*	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	392					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CCAGGCAATTCAGCTCCAGAC	0.622		NaN											0	0	0	0.00308	0	8	38									
DSP	1832	broad.mit.edu	37	6	7583844	7583844	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:7583844G>C	uc003mxp.1	+	24	6628	c.6349G>C	c.(6349-6351)GAT>CAT	p.D2117H	DSP_uc003mxq.1_Missense_Mutation_p.D1518H	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2117	Globular 2.|Plectin 3.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAATTTGATTGATAGAGAAAC	0.443		NaN											0	0	0	0.00632	0	27	109									
NEDD9	4739	broad.mit.edu	37	6	11190647	11190647	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:11190647C>T	uc003mzv.2	-	5	1622	c.1455G>A	c.(1453-1455)ATG>ATA	p.M485I	NEDD9_uc010joz.2_Missense_Mutation_p.M485I|NEDD9_uc003mzw.3_Missense_Mutation_p.M339I	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	485					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			GCTCCCGCTTCATCTTGTTGT	0.522		NaN											0	0	0	0.001368	0	12	38									
SIRT5	23408	broad.mit.edu	37	6	13592071	13592071	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:13592071G>A	uc003nay.2	+	5	716	c.420G>A	c.(418-420)CAG>CAA	p.Q140Q	SIRT5_uc003naw.2_Silent_p.Q140Q|SIRT5_uc003nax.2_Silent_p.Q32Q|SIRT5_uc011dit.1_Silent_p.Q140Q	NM_012241	NP_036373	Q9NXA8	SIRT5_HUMAN	sirtuin 5 isoform 1	140	NAD.|Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			skin(2)|upper_aerodigestive_tract(1)	3	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	TCATCACCCAGAACATCGATG	0.617		NaN											0	0	0	0.001855	0	12	46									
HIST1H2BE	8344	broad.mit.edu	37	6	26184038	26184038	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:26184038G>A	uc003ngt.2	+	1	15	c.15G>A	c.(13-15)GCG>GCA	p.A5A		NM_003523	NP_003514	P62807	H2B1C_HUMAN	histone cluster 1, H2be	5				A -> S (in Ref. 2; CAB02545).	defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						CTGAGCCAGCGAAATCCGCTC	0.512		NaN											0	0	0	0.007291	0	29	73									
HIST1H2AG	8969	broad.mit.edu	37	6	27101075	27101075	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:27101075G>C	uc003niw.2	+	1	259	c.225G>C	c.(223-225)AAG>AAC	p.K75N	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	75					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						GCGACAACAAGAAGACCCGCA	0.662		NaN											0	0	0	0.00499	0	16	91									
ZNF311	282890	broad.mit.edu	37	6	28966565	28966565	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:28966565C>G	uc003nlu.2	-	6	874	c.361G>C	c.(361-363)GAC>CAC	p.D121H	ZNF311_uc011dlk.1_Missense_Mutation_p.D29H|ZNF311_uc003nlv.2_Missense_Mutation_p.D29H	NM_001010877	NP_001010877	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						ACACAGGGGTCTACTTCTCGC	0.448		NaN											0	0	0	0.000978	0	10	68									
OR11A1	26531	broad.mit.edu	37	6	29394644	29394644	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:29394644A>G	uc003nmg.2	-	1	866	c.775T>C	c.(775-777)TTT>CTT	p.F259L		NM_013937	NP_039225	Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A,	259	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GCAACATAAAAGATCATGAGC	0.522		NaN											0	0	0	0.003163	0	15	89									
HLA-F	3134	broad.mit.edu	37	6	29694183	29694183	+	Nonstop_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:29694183G>T	uc010jrl.2	+	7	1164	c.1040G>T	c.(1039-1041)TGA>TTA	p.*347L	HLA-F_uc003nnm.3_Nonstop_Mutation_p.*255L|HLA-F_uc003nno.3_Intron|HLA-F_uc011dlx.1_Intron|HLA-F_uc011dly.1_Intron	NM_018950	NP_061823	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	347					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity				0						TCTATAGTGTGAGACAGCTTC	0.353		NaN											1	0	9.70103e-10	0.008291	1.19807e-09	9	47									
ABCF1	23	broad.mit.edu	37	6	30552094	30552094	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:30552094G>A	uc003nql.2	+	13	1323	c.1228G>A	c.(1228-1230)GAG>AAG	p.E410K	ABCF1_uc003nqk.2_Missense_Mutation_p.E411K|ABCF1_uc003nqm.2_Missense_Mutation_p.E372K|ABCF1_uc010jsb.2_Intron|MIR877_hsa-mir-877|MI0005561_5'Flank	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	410	ABC transporter 1.				inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						CACAGCTGCTGAGAGGCTAGA	0.597		NaN											0	0	0	0.001523	0	19	65									
BAT4	7918	broad.mit.edu	37	6	31631705	31631705	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:31631705G>A	uc003nvn.2	-	2	1196	c.551C>T	c.(550-552)GCT>GTT	p.A184V	BAT4_uc003nvo.3_Missense_Mutation_p.A184V|BAT4_uc003nvp.3_Missense_Mutation_p.A184V|BAT4_uc003nvq.2_Missense_Mutation_p.A184V|CSNK2B_uc010jsz.1_5'Flank|CSNK2B_uc010jta.1_5'Flank|CSNK2B_uc003nvr.1_5'Flank|CSNK2B_uc003nvs.1_5'Flank	NM_033177	NP_149417	O95872	GPAN1_HUMAN	HLA-B associated transcript 4	184						intracellular	nucleic acid binding				0						AGCTTCTTCAGCGAGCTGAGC	0.642		NaN											0	0	0	0.007413	0	19	40									
LY6G6F	259215	broad.mit.edu	37	6	31685395	31685395	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:31685395C>G	uc003nwb.1	+	6	963	c.963C>G	c.(961-963)GTC>GTG	p.V321V	LY6G6D_uc003nwf.1_Silent_p.V72V|LY6G6D_uc003nwg.1_Silent_p.V51V	NM_001003693	NP_001003693	Q5SQ64	LY66F_HUMAN	G6f protein precursor	Error:Variant_position_missing_in_Q5SQ64_after_alignment						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)	2						CAGCCTGCGTCGCAGCCCATC	0.577		NaN											0	0	0	0.00361	0	74	195									
MSH5	4439	broad.mit.edu	37	6	31711763	31711763	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:31711763C>G	uc003nwv.1	+	6	577	c.498C>G	c.(496-498)CTC>CTG	p.L166L	MSH5_uc003nwt.1_Silent_p.L166L|MSH5_uc003nwu.1_Silent_p.L166L|MSH5_uc003nww.1_Silent_p.L166L|MSH5_uc003nwx.1_Silent_p.L166L|MSH5_uc011dof.1_5'Flank	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	166					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						AGAAAATCCTCTTCCTCTCTT	0.517		NaN						Direct_reversal_of_damage|MMR					0	0	0	0.005524	0	37	228									
TNXB	7148	broad.mit.edu	37	6	32026081	32026081	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:32026081C>T	uc003nzl.2	-	22	7781	c.7579G>A	c.(7579-7581)GAG>AAG	p.E2527K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2587	Fibronectin type-III 18.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						ACTGTCAGCTCCCCCAGGAGA	0.627		NaN											0	0	0	0.00308	0	8	32									
PHF1	5252	broad.mit.edu	37	6	33380560	33380560	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:33380560G>A	uc003oeh.2	+	4	563	c.327G>A	c.(325-327)AAG>AAA	p.K109K	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_Silent_p.K109K|PHF1_uc010jux.2_Intron	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	109	PHD-type 1.				chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				GCTGTGAGAAGTGTCGCCATG	0.577		NaN											0	0	0	0.008871	0	19	50									
PHF1	5252	broad.mit.edu	37	6	33383647	33383647	+	Silent	SNP	G	G	C	rs138734488		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:33383647G>C	uc003oeh.2	+	15	1712	c.1476G>C	c.(1474-1476)TCG>TCC	p.S492S	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_Missense_Mutation_p.R457P|PHF1_uc010jux.2_Silent_p.S292S	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	492					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				CCCCCCACTCGATGACTGCCT	0.542		NaN											0	0	0	0.003755	0	32	105									
PHF1	5252	broad.mit.edu	37	6	33383743	33383743	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:33383743G>A	uc003oeh.2	+	15	1808	c.1572G>A	c.(1570-1572)GGG>GGA	p.G524G	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_3'UTR|PHF1_uc010jux.2_Silent_p.G324G	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	524					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				TGTCTCCTGGGACTGGGGGAG	0.612		NaN											0	0	0	0.003755	0	36	101									
PHF1	5252	broad.mit.edu	37	6	33383754	33383754	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:33383754G>C	uc003oeh.2	+	15	1819	c.1583G>C	c.(1582-1584)GGA>GCA	p.G528A	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_3'UTR|PHF1_uc010jux.2_Missense_Mutation_p.G328A	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	528					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				ACTGGGGGAGGAGTCCGAGGT	0.617		NaN											0	0	0	0.00278	0	22	123									
USP49	25862	broad.mit.edu	37	6	41774070	41774070	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:41774070C>T	uc003ori.2	-	4	874	c.652G>A	c.(652-654)GAC>AAC	p.D218N		NM_018561	NP_061031	Q70CQ1	UBP49_HUMAN	ubiquitin thioesterase 49	218					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			gggcccgcgtcgcggggcgTG	0.577		NaN											0	0	0	0.00308	0	8	12									
UBR2	23304	broad.mit.edu	37	6	42655960	42655960	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:42655960G>A	uc011dur.1	+	45	4860	c.4860G>A	c.(4858-4860)CCG>CCA	p.P1620P	UBR2_uc011dus.1_Silent_p.P1265P|UBR2_uc003osh.2_RNA|UBR2_uc011dut.1_Silent_p.P208P|UBR2_uc011duu.1_Silent_p.P12P	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	1620					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			GGAGGTGCCCGAAATCAGGTG	0.428		NaN											0	0	0	0.004007	0	17	119									
CUL9	23113	broad.mit.edu	37	6	43172787	43172787	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:43172787C>T	uc003ouk.2	+	23	4641	c.4566C>T	c.(4564-4566)TTC>TTT	p.F1522F	CUL9_uc003oul.2_Silent_p.F1522F|CUL9_uc010jyk.2_Silent_p.F674F	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1522					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GGGCAGCCTTCATGCTGGCTC	0.602		NaN											0	0	0	0.004656	0	26	59									
CAPN11	11131	broad.mit.edu	37	6	44148506	44148506	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:44148506G>A	uc003owt.1	+	17	1806	c.1768G>A	c.(1768-1770)GAG>AAG	p.E590K	CAPN11_uc011dvn.1_Missense_Mutation_p.E244K	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	590	Domain IV.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AGGGGTGTATGAGCTCCAGAG	0.602		NaN											0	0	0	0.00245	0	12	46									
HSP90AB1	3326	broad.mit.edu	37	6	44219877	44219877	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:44219877C>G	uc003oxa.1	+	10	1688	c.1604C>G	c.(1603-1605)TCA>TGA	p.S535*	HSP90AB1_uc011dvr.1_Nonsense_Mutation_p.S525*|HSP90AB1_uc003oxb.1_Nonsense_Mutation_p.S535*|HSP90AB1_uc011dvs.1_Nonsense_Mutation_p.S355*|HSP90AB1_uc003oxc.1_Nonsense_Mutation_p.S173*	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	535					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AGCCTGGTCTCAGTTACCAAG	0.517		NaN											0	0	0	0.001984	0	7	38									
TDRD6	221400	broad.mit.edu	37	6	46660346	46660346	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:46660346G>C	uc003oyj.2	+	1	4481	c.4481G>C	c.(4480-4482)AGT>ACT	p.S1494T	TDRD6_uc010jze.2_Missense_Mutation_p.S1488T	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1494					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GTAATTAAAAGTGCCAGTTCA	0.348		NaN											0	0	0	0.008291	0	10	68									
TDRD6	221400	broad.mit.edu	37	6	46660716	46660716	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:46660716C>G	uc003oyj.2	+	1	4851	c.4851C>G	c.(4849-4851)CTC>CTG	p.L1617L	TDRD6_uc010jze.2_Silent_p.L1611L	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1617	Tudor 7.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CAAAAGCACTCTGGGCCATTC	0.423		NaN											0	0	0	0.001523	0	17	81									
TDRD6	221400	broad.mit.edu	37	6	46660747	46660747	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:46660747C>G	uc003oyj.2	+	1	4882	c.4882C>G	c.(4882-4884)CCC>GCC	p.P1628A	TDRD6_uc010jze.2_Missense_Mutation_p.P1622A	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1628					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			TCTGTCGGTTCCCATGCAAGC	0.413		NaN											0	0	0	0.001882	0	22	67									
TDRD6	221400	broad.mit.edu	37	6	46661399	46661399	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:46661399C>G	uc003oyj.2	+	1	5534	c.5534C>G	c.(5533-5535)TCA>TGA	p.S1845*	TDRD6_uc010jze.2_Nonsense_Mutation_p.S1839*	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1845					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GATGATGAATCAAAAGAATTC	0.418		NaN											0	0	0	0.000978	0	11	71									
TDRD6	221400	broad.mit.edu	37	6	46665740	46665740	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:46665740G>C	uc003oyj.2	+	3	6177	c.6177G>C	c.(6175-6177)TTG>TTC	p.L2059F	TDRD6_uc010jze.2_Intron	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	2059	Tudor 8.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			TGTAGGTTTTGAACCTTTCAA	0.308		NaN											0	0	0	0.002096	0	28	135									
GPR110	266977	broad.mit.edu	37	6	46996735	46996735	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:46996735G>A	uc003oyt.2	-	2	262	c.63C>T	c.(61-63)TTC>TTT	p.F21F	GPR110_uc011dwl.1_5'UTR|GPR110_uc003oyu.1_Silent_p.F21F	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	21	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TCACCCCCAGGAAGCCACCGT	0.517		NaN											0	0	0	0.000978	0	9	51									
PGK2	5232	broad.mit.edu	37	6	49754286	49754286	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:49754286C>T	uc003ozu.2	-	1	722	c.615G>A	c.(613-615)GTG>GTA	p.V205V		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	205					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					GAAAGGGTCTCACTGGGTTTT	0.433		NaN											0	0	0	0.006122	0	19	80									
FAM83B	222584	broad.mit.edu	37	6	54805774	54805774	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:54805774G>C	uc003pck.2	+	5	2121	c.2005G>C	c.(2005-2007)GAC>CAC	p.D669H		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	669										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					CCCGTTATTTGACAACTCAAA	0.343		NaN											0	0	0	0.007413	0	17	65									
KCNQ5	56479	broad.mit.edu	37	6	73751754	73751754	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:73751754G>A	uc003pgk.2	+	3	932	c.585G>A	c.(583-585)CTG>CTA	p.L195L	KCNQ5_uc003pgj.3_Silent_p.L195L|KCNQ5_uc011dyh.1_Silent_p.L195L|KCNQ5_uc011dyi.1_Silent_p.L195L|KCNQ5_uc010kat.2_Silent_p.L195L|KCNQ5_uc011dyj.1_Silent_p.L195L|KCNQ5_uc011dyk.1_Intron	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	195					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		AAGGAAGACTGAGGTTTGCTC	0.438		NaN											0	0	0	0.007291	0	27	122									
KCNQ5	56479	broad.mit.edu	37	6	73904609	73904609	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:73904609C>G	uc003pgk.2	+	14	2618	c.2271C>G	c.(2269-2271)ATC>ATG	p.I757M	KCNQ5_uc011dyh.1_Missense_Mutation_p.I776M|KCNQ5_uc011dyi.1_Missense_Mutation_p.I767M|KCNQ5_uc010kat.2_Missense_Mutation_p.I748M|KCNQ5_uc011dyj.1_Missense_Mutation_p.I647M|KCNQ5_uc011dyk.1_Missense_Mutation_p.I507M	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	757					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TCCCAGCCATCAAGCATCTGC	0.537		NaN											0	0	0	0.007413	0	17	34									
C6orf150	115004	broad.mit.edu	37	6	74150012	74150012	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:74150012G>T	uc003pgx.1	-	3	1173	c.1034C>A	c.(1033-1035)TCA>TAA	p.S345*		NM_138441	NP_612450	Q8N884	M21D1_HUMAN	hypothetical protein LOC115004	345											0						AACTTTTGCTGAAAGCCAGTT	0.393		NaN											1	0	1.2476e-16	0.00632	1.57315e-16	30	76									
CD109	135228	broad.mit.edu	37	6	74502507	74502507	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:74502507C>T	uc003php.2	+	23	3285	c.2860C>T	c.(2860-2862)CTT>TTT	p.L954F	CD109_uc010kaz.2_Intron|CD109_uc003phq.2_Missense_Mutation_p.L954F|CD109_uc010kba.2_Missense_Mutation_p.L877F	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	954						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						AGAAAAAGCTCTTTCATTTAT	0.303		NaN											0	0	0	0.006214	0	10	35									
COL12A1	1303	broad.mit.edu	37	6	75831126	75831126	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:75831126G>C	uc003phs.2	-	44	7144	c.6978C>G	c.(6976-6978)TTC>TTG	p.F2326L	COL12A1_uc003pht.2_Missense_Mutation_p.F1162L	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2326	VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CATCAGTCAAGAACACAATAT	0.388		NaN											0	0	0	0.00632	0	25	79									
MDN1	23195	broad.mit.edu	37	6	90442463	90442463	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:90442463G>A	uc003pnn.1	-	34	4871	c.4755C>T	c.(4753-4755)TTC>TTT	p.F1585F		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	1585					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GCCAGTCAATGAAATCCAGCA	0.438		NaN											0	0	0	0.003163	0	14	88									
CASP8AP2	9994	broad.mit.edu	37	6	90577917	90577917	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:90577917G>C	uc003pnr.2	+	8	5104	c.4908G>C	c.(4906-4908)AAG>AAC	p.K1636N	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.K1636N|CASP8AP2_uc011dzz.1_Missense_Mutation_p.K1636N	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1636					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		CTTCAGATAAGATGGGTCATA	0.368		NaN											0	0	0	0.003163	0	14	45									
GPR63	81491	broad.mit.edu	37	6	97247300	97247300	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:97247300C>A	uc010kcl.2	-	3	786	c.308G>T	c.(307-309)TGC>TTC	p.C103F	GPR63_uc003pou.2_Missense_Mutation_p.C103F	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	103	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		AACCATGAGGCAAACAACCAA	0.443		NaN											1	0	3.45872e-05	0.004007	4.147e-05	16	44									
MICAL1	64780	broad.mit.edu	37	6	109769984	109769984	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:109769984C>T	uc003ptj.2	-	11	1869	c.1615G>A	c.(1615-1617)GAT>AAT	p.D539N	MICAL1_uc003ptk.2_Missense_Mutation_p.D539N|MICAL1_uc010kdr.2_Missense_Mutation_p.D453N|MICAL1_uc011eaq.1_Missense_Mutation_p.D558N	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	539	CH.				cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		GCTAGCCCATCAGCCCAGGAG	0.622		NaN											0	0	0	0.00361	0	56	122									
RWDD1	51389	broad.mit.edu	37	6	116892761	116892761	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:116892761G>A	uc003pxd.2	+	1	179	c.16G>A	c.(16-18)GAG>AAG	p.E6K	RWDD1_uc003pxb.2_5'UTR|RWDD1_uc003pxc.2_5'UTR	NM_015952	NP_057036	Q9H446	RWDD1_HUMAN	RWD domain containing 1 isoform a	6							protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.0312)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)|Epithelial(106;0.161)		AGATTACGGCGAGGAGCAGCG	0.677		NaN											0	0	0	0.004482	0	7	36									
RWDD1	51389	broad.mit.edu	37	6	116914217	116914217	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:116914217G>A	uc003pxd.2	+	7	848	c.685G>A	c.(685-687)GAT>AAT	p.D229N	RWDD1_uc003pxb.2_Missense_Mutation_p.D133N|RWDD1_uc003pxc.2_Missense_Mutation_p.D133N	NM_015952	NP_057036	Q9H446	RWDD1_HUMAN	RWD domain containing 1 isoform a	229							protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.0312)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)|Epithelial(106;0.161)		TGATGAAGATGATCCAGACTA	0.468		NaN											0	0	0	0.000978	0	12	50									
RSPH4A	345895	broad.mit.edu	37	6	116938321	116938321	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:116938321G>A	uc003pxe.2	+	1	680	c.535G>A	c.(535-537)GAC>AAC	p.D179N	RSPH4A_uc010kee.2_Missense_Mutation_p.D179N	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	179					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						GCTGAGATTTGACGTTTTTCA	0.502		NaN							Kartagener_syndrome				0	0	0	0.004656	0	26	155									
GPRC6A	222545	broad.mit.edu	37	6	117127555	117127555	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:117127555G>A	uc003pxj.1	-	3	1335	c.1313C>T	c.(1312-1314)CCC>CTC	p.P438L	GPRC6A_uc003pxk.1_Intron|GPRC6A_uc003pxl.1_Missense_Mutation_p.P438L	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	438	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		AAAGGCGTTGGGGTTCTGACA	0.448		NaN											0	0	0	0.000978	0	12	50									
HSF2	3298	broad.mit.edu	37	6	122743440	122743440	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:122743440C>G	uc003pyu.2	+	8	1014	c.827C>G	c.(826-828)TCC>TGC	p.S276C	HSF2_uc003pyv.2_Missense_Mutation_p.S276C	NM_004506	NP_004497	Q03933	HSF2_HUMAN	heat shock transcription factor 2 isoform a	276					response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		TCTGATCCCTCCAAGTAAGGA	0.274		NaN											0	0	0	0.00361	0	43	165									
CTGF	1490	broad.mit.edu	37	6	132271151	132271151	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:132271151C>G	uc003qcz.2	-	4	897	c.691G>C	c.(691-693)GAG>CAG	p.E231Q		NM_001901	NP_001892	P29279	CTGF_HUMAN	connective tissue growth factor precursor	231	TSP type-1.				cellular lipid metabolic process|DNA replication|epidermis development|regulation of cell growth|response to wounding	plasma membrane|proteinaceous extracellular matrix	heparin binding|insulin-like growth factor binding				0	Breast(56;0.0602)			GBM - Glioblastoma multiforme(226;0.015)|OV - Ovarian serous cystadenocarcinoma(155;0.0169)		CTCTGCTTCTCTAGCCTGCAG	0.537		NaN									OREG0017666	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004007	0	14	31									
AHI1	54806	broad.mit.edu	37	6	135679284	135679284	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:135679284C>G	uc003qgi.2	-	24	3535	c.3151G>C	c.(3151-3153)GAT>CAT	p.D1051H	AHI1_uc003qgf.2_RNA|AHI1_uc003qgg.2_Missense_Mutation_p.D501H|AHI1_uc003qgh.2_Missense_Mutation_p.D1051H|AHI1_uc003qgj.2_Missense_Mutation_p.D1051H|AHI1_uc003qgk.3_RNA	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	1051	SH3.					adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		GGTGCTGTATCTACCTGATGG	0.353		NaN											0	0	0	0.00361	0	75	295									
MAP7	9053	broad.mit.edu	37	6	136681163	136681163	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:136681163C>G	uc003qgz.2	-	14	2056	c.1810G>C	c.(1810-1812)GAG>CAG	p.E604Q	MAP7_uc011edf.1_Missense_Mutation_p.E589Q|MAP7_uc011edg.1_Missense_Mutation_p.E634Q|MAP7_uc010kgu.2_Missense_Mutation_p.E626Q|MAP7_uc011edh.1_Missense_Mutation_p.E589Q|MAP7_uc010kgv.2_Missense_Mutation_p.E626Q|MAP7_uc010kgs.2_Missense_Mutation_p.E458Q|MAP7_uc011edi.1_Missense_Mutation_p.E458Q|MAP7_uc010kgq.1_Missense_Mutation_p.E510Q|MAP7_uc003qha.1_Missense_Mutation_p.E567Q	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	604	Potential.				establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		ATAATCTCCTCAAGTCGCTAT	0.343		NaN											0	0	0	0.006122	0	18	51									
KIAA1244	57221	broad.mit.edu	37	6	138612877	138612877	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:138612877G>C	uc003qhu.2	+	19	3055	c.3055G>C	c.(3055-3057)GAA>CAA	p.E1019Q		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1019					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		TAGGGTGTGTGAATACGTGGG	0.602		NaN											0	0	0	0.000248	0	4	13									
TAB2	23118	broad.mit.edu	37	6	149700238	149700238	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:149700238G>C	uc003qmj.2	+	3	1365	c.1187G>C	c.(1186-1188)GGA>GCA	p.G396A	TAB2_uc011eec.1_Missense_Mutation_p.G364A|TAB2_uc010kia.1_Missense_Mutation_p.G396A|TAB2_uc010kib.1_Missense_Mutation_p.G396A|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	396					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						GCTGCCACAGGAGATGAACAG	0.512		NaN											0	0	0	0.008291	0	10	45									
TAB2	23118	broad.mit.edu	37	6	149730837	149730837	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:149730837G>C	uc003qmj.2	+	7	2242	c.2064G>C	c.(2062-2064)GAG>GAC	p.E688D	TAB2_uc011eec.1_Missense_Mutation_p.E656D|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	688	RanBP2-type.				activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						AACAGTGTGAGATGCCAAGGC	0.433		NaN											0	0	0	0.005524	0	36	100									
SYNE1	23345	broad.mit.edu	37	6	152551728	152551728	+	Missense_Mutation	SNP	C	C	G	rs143639400		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:152551728C>G	uc010kiw.2	-	115	21751	c.21149G>C	c.(21148-21150)CGA>CCA	p.R7050P	SYNE1_uc010kiv.2_Missense_Mutation_p.R1574P|SYNE1_uc003qos.3_Missense_Mutation_p.R1574P|SYNE1_uc003qot.3_Missense_Mutation_p.R6979P|SYNE1_uc003qou.3_Missense_Mutation_p.R7050P	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7050	Cytoplasmic (Potential).|Spectrin 22.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATCTCCAATTCGATGCTGTTG	0.393		NaN								HNSCC(10;0.0054)			0	0	0	0.004656	0	25	131									
SYTL3	94120	broad.mit.edu	37	6	159181754	159181754	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:159181754G>A	uc003qrp.2	+	14	1635	c.1391G>A	c.(1390-1392)AGA>AAA	p.R464K	SYTL3_uc011efp.1_Missense_Mutation_p.R464K|SYTL3_uc003qro.2_Missense_Mutation_p.R396K|SYTL3_uc003qrq.2_Missense_Mutation_p.R396K|SYTL3_uc003qrr.2_Missense_Mutation_p.R464K|SYTL3_uc003qrs.2_Missense_Mutation_p.R396K|SYTL3_uc011efq.1_Missense_Mutation_p.R190K	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	464					intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		TCACGGCCCAGAAAACTCCAA	0.567		NaN											0	0	0	0.006122	0	17	41									
SYTL3	94120	broad.mit.edu	37	6	159184504	159184504	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:159184504G>T	uc003qrp.2	+	16	1930	c.1686G>T	c.(1684-1686)ATG>ATT	p.M562I	SYTL3_uc011efp.1_Missense_Mutation_p.M562I|SYTL3_uc003qro.2_Missense_Mutation_p.M494I|SYTL3_uc003qrq.2_Missense_Mutation_p.M494I|SYTL3_uc003qrr.2_Missense_Mutation_p.M562I|SYTL3_uc003qrs.2_Missense_Mutation_p.M494I|SYTL3_uc011efq.1_Missense_Mutation_p.M288I	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	562	C2 2.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		TCTTTGGAATGAACGACCGCT	0.488		NaN											1	0	1.5842e-08	0.001855	1.93326e-08	13	85									
RPS6KA2	6196	broad.mit.edu	37	6	166844058	166844058	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:166844058C>T	uc003qvb.1	-	16	1683	c.1464G>A	c.(1462-1464)CTG>CTA	p.L488L	RPS6KA2_uc011ego.1_Silent_p.L399L|RPS6KA2_uc010kkl.1_Silent_p.L399L|RPS6KA2_uc003qvc.1_Silent_p.L496L|RPS6KA2_uc003qvd.1_Silent_p.L513L	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	488	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		CACCACGCATCAGCTCCATTA	0.577		NaN											0	0	0	0.00245	0	14	45									
TTYH3	80727	broad.mit.edu	37	7	2701309	2701309	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:2701309C>G	uc003smp.2	+	14	1695	c.1508C>G	c.(1507-1509)TCC>TGC	p.S503C	TTYH3_uc010ksn.2_Missense_Mutation_p.S223C|TTYH3_uc003smq.2_Missense_Mutation_p.S332C	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	503	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		CAGTACACCTCCAGCATGAGA	0.682		NaN											0	0	0	0.004482	0	8	15									
CARD11	84433	broad.mit.edu	37	7	2957020	2957020	+	Splice_Site	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:2957020C>G	uc003smv.2	-	20	3012	c.2608_splice	c.e20-1	p.N870_splice		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11						positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GCAGGGTGTTCTGAAATGAAT	0.562		NaN	Mis		DLBCL								0	0	0	0.007413	0	19	45									
MIOS	54468	broad.mit.edu	37	7	7622975	7622975	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:7622975C>G	uc003srf.2	+	6	1928	c.1620C>G	c.(1618-1620)ATC>ATG	p.I540M	MIOS_uc003srg.2_Missense_Mutation_p.I75M|MIOS_uc010ktq.2_5'Flank	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	540											0						CAATCCAAATCCTGAATGAAG	0.388		NaN											0	0	0	0.001855	0	12	52									
THSD7A	221981	broad.mit.edu	37	7	11468661	11468661	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:11468661C>G	uc003ssf.3	-	14	3408	c.3156G>C	c.(3154-3156)GGG>GGC	p.G1052G		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1052	TSP type-1 11.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TCACACCACTCCCACAGGACT	0.517		NaN								HNSCC(18;0.044)			0	0	0	0.00361	0	95	283									
HOXA10	3206	broad.mit.edu	37	7	27211670	27211670	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:27211670G>T	uc011jzm.1	-	2	1111	c.1081C>A	c.(1081-1083)CTT>ATT	p.L361I	MIR196B_hsa-mir-196b|MI0001150_5'Flank|HOXA10_uc003syw.3_Missense_Mutation_p.L45I	NM_018951	NP_061824	P31260	HXA10_HUMAN	homeobox A10 isoform a	361	Homeobox.				spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCTCGAGTAAGGTACATATTG	0.522		NaN											1	0	1.52378e-38	0.00361	1.95217e-38	75	696									
KBTBD2	25948	broad.mit.edu	37	7	32909880	32909880	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:32909880C>G	uc003tdb.2	-	4	1608	c.949G>C	c.(949-951)GAT>CAT	p.D317H	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	317	Kelch 1.										0			GBM - Glioblastoma multiforme(11;0.0499)			ATGTAGATATCATTATCAGGA	0.413		NaN											0	0	0	0.00632	0	28	83									
C7orf25	79020	broad.mit.edu	37	7	42949965	42949965	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:42949965C>G	uc003thw.2	-	2	999	c.535G>C	c.(535-537)GAG>CAG	p.E179Q	C7orf25_uc010kxq.2_Missense_Mutation_p.E179Q|C7orf25_uc003thx.3_Missense_Mutation_p.E237Q|C7orf25_uc010kxr.2_Missense_Mutation_p.E237Q	NM_024054	NP_076959	Q9BPX7	CG025_HUMAN	hypothetical protein LOC79020 b	179										skin(1)	1						TTCAGCTTCTCTGCCATGGGG	0.493		NaN											0	0	0	0.001368	0	13	88									
GCK	2645	broad.mit.edu	37	7	44192943	44192943	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:44192943C>T	uc003tkl.2	-	2	635	c.165G>A	c.(163-165)GTG>GTA	p.V55V	GCK_uc003tkj.1_Silent_p.V54V|GCK_uc003tkk.1_Silent_p.V56V	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	55					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						GCAGCATCTTCACACTGGCCT	0.602		NaN											0	0	0	0.00361	0	65	131									
GCK	2645	broad.mit.edu	37	7	44193018	44193018	+	Silent	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:44193018C>A	uc003tkl.2	-	2	560	c.90G>T	c.(88-90)CTG>CTT	p.L30L	GCK_uc003tkj.1_Silent_p.L29L|GCK_uc003tkk.1_Silent_p.L31L	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	30					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						TCACCTTCTTCAGGTCCTCCT	0.632		NaN											1	0	9.47799e-51	0.00361	1.21751e-50	83	225									
YKT6	10652	broad.mit.edu	37	7	44250704	44250704	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:44250704C>G	uc003tkm.2	+	6	699	c.542C>G	c.(541-543)TCT>TGT	p.S181C	YKT6_uc011kbv.1_Intron	NM_006555	NP_006546	O15498	YKT6_HUMAN	YKT6 v-SNARE protein	181	v-SNARE coiled-coil homology.				ER to Golgi vesicle-mediated transport|protein transport|retrograde transport, endosome to Golgi|vesicle docking involved in exocytosis|vesicle targeting	cytoplasmic vesicle membrane|cytosol|endoplasmic reticulum|endosome|Golgi membrane|integral to plasma membrane|mitochondrion|SNARE complex	protein-cysteine S-palmitoleyltransferase activity|SNAP receptor activity				0						GGAACACAGTCTAAAGCCTTC	0.502		NaN											0	0	0	0.000978	0	12	41									
ABCA13	154664	broad.mit.edu	37	7	48319282	48319282	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:48319282C>T	uc003toq.2	+	18	8516	c.8491C>T	c.(8491-8493)CTG>TTG	p.L2831L	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2831				L -> R (in Ref. 1; AAP13576).	transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GAAAGGACTTCTGTTTAACAA	0.348		NaN											0	0	0	0.00361	0	48	116									
ABCA13	154664	broad.mit.edu	37	7	48559842	48559842	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:48559842T>G	uc003toq.2	+	53	14028	c.14003T>G	c.(14002-14004)CTT>CGT	p.L4668R	ABCA13_uc010kys.1_Missense_Mutation_p.L1743R|ABCA13_uc010kyt.1_RNA|ABCA13_uc010kyu.1_Missense_Mutation_p.L398R	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4668	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GGCACAGTACTTCTCCTCTTG	0.527		NaN											0	0	0	0.000602	0	5	43									
POM121L12	285877	broad.mit.edu	37	7	53104099	53104099	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:53104099C>T	uc003tpz.2	+	1	751	c.735C>T	c.(733-735)CTC>CTT	p.L245L		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	245											0						CCTGGAGCCTCAGTTTTTGTG	0.647		NaN											0	0	0	0.004007	0	17	66									
SEPT14	346288	broad.mit.edu	37	7	55873034	55873034	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:55873034G>A	uc003tqz.2	-	9	1153	c.1036C>T	c.(1036-1038)CAG>TAG	p.Q346*		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	346	Potential.				cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TCTTCCCTCTGACATTGATCA	0.303		NaN											0	0	0	0.000602	0	5	52									
AUTS2	26053	broad.mit.edu	37	7	70228261	70228261	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:70228261C>G	uc003tvw.3	+	7	1891	c.1148C>G	c.(1147-1149)TCT>TGT	p.S383C	AUTS2_uc003tvx.3_Missense_Mutation_p.S383C|AUTS2_uc011keg.1_5'Flank	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	383	Ser-rich.									ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GCCCACCCCTCTGCTCAGAGC	0.607		NaN											0	0	0	0.001368	0	10	106									
TYW1B	441250	broad.mit.edu	37	7	72081725	72081725	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:72081725G>C	uc011kej.1	-	16	1876	c.1717C>G	c.(1717-1719)CTG>GTG	p.L573V	TYW1B_uc011keh.1_Missense_Mutation_p.L411V|TYW1B_uc011kei.1_Missense_Mutation_p.L199V	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	573					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						TCGGGGATCAGATCCACCAGC	0.473		NaN											0	0	0	0.00278	0	24	86									
EIF4H	7458	broad.mit.edu	37	7	73588773	73588773	+	Splice_Site	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:73588773G>A	uc003uad.1	+	1	67	c.59_splice	c.e1+1	p.G20_splice	RFC2_uc011kfa.1_Intron|EIF4H_uc011kfg.1_Splice_Site_p.G20_splice|EIF4H_uc010lbm.2_Splice_Site_p.G20_splice|EIF4H_uc003uae.1_Splice_Site_p.G20_splice|EIF4H_uc003uaf.1_Splice_Site	NM_022170	NP_071496	Q15056	IF4H_HUMAN	eukaryotic translation initiation factor 4H						interspecies interaction between organisms|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity				0						GCGGCAGAGGGTGAGGCGGGC	0.667		NaN											0	0	0	0.000978	0	9	55									
FGL2	10875	broad.mit.edu	37	7	76828608	76828608	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:76828608T>G	uc003ugb.2	-	1	543	c.503A>C	c.(502-504)AAC>ACC	p.N168T	CCDC146_uc003ufz.1_Intron|CCDC146_uc003uga.2_Intron	NM_006682	NP_006673	Q14314	FGL2_HUMAN	fibrinogen-like 2 precursor	168					signal transduction	fibrinogen complex	receptor binding			skin(2)	2						ATTTTCTATGTTGTTCATATT	0.388		NaN											0	0	0	0.005443	0	28	88									
PION	54103	broad.mit.edu	37	7	76984619	76984619	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:76984619G>A	uc003ugf.2	-	16	1328	c.1249C>T	c.(1249-1251)CTG>TTG	p.L417L	PION_uc003ugg.1_Silent_p.L202L	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	417					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						GTGTTCTGCAGAAGCTGTAAT	0.502		NaN											0	0	0	0.00623	0	42	122									
PTPN12	5782	broad.mit.edu	37	7	77256781	77256781	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:77256781C>T	uc003ugh.2	+	13	1876	c.1785C>T	c.(1783-1785)CTC>CTT	p.L595L	PTPN12_uc011kgp.1_Silent_p.L476L|PTPN12_uc011kgq.1_Silent_p.L465L|PTPN12_uc010lds.2_Silent_p.L327L	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	595						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						GAACACCCCTCAGTTTTACTA	0.403		NaN											0	0	0	0.002852	0	44	134									
CACNA2D1	781	broad.mit.edu	37	7	81667445	81667445	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:81667445C>T	uc003uhr.1	-	11	1242	c.986G>A	c.(985-987)GGA>GAA	p.G329E		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	329	Extracellular (Potential).|VWFA.					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	atctgtaattcctttggctGT	0.294		NaN											0	0	0	0.002096	0	33	87									
ZNF804B	219578	broad.mit.edu	37	7	88966042	88966042	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:88966042C>G	uc011khi.1	+	4	4284	c.3746C>G	c.(3745-3747)TCG>TGG	p.S1249W		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1249						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			ATTTCATTTTCGACTCTGACT	0.458		NaN								HNSCC(36;0.09)			0	0	0	0.001855	0	14	169									
STEAP1	26872	broad.mit.edu	37	7	89789150	89789150	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:89789150G>A	uc003ujx.2	+	2	248	c.48G>A	c.(46-48)ATG>ATA	p.M16I	STEAP1_uc010lem.2_Missense_Mutation_p.M16I	NM_012449	NP_036581	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the	16					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	all_hematologic(106;0.112)					TTTGGAAAATGAAGCCTAGGA	0.254		NaN											0	0	0	0.008291	0	10	105									
CDK14	5218	broad.mit.edu	37	7	90356077	90356077	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:90356077C>G	uc003uky.2	+	3	542	c.320C>G	c.(319-321)TCC>TGC	p.S107C	CDK14_uc003ukt.1_Missense_Mutation_p.S61C|CDK14_uc003ukv.1_Missense_Mutation_p.S61C|CDK14_uc003uku.1_Missense_Mutation_p.S61C|CDK14_uc003ukx.1_Intron|CDK14_uc003ukz.1_Missense_Mutation_p.S89C|CDK14_uc010les.1_Missense_Mutation_p.S61C|CDK14_uc011khl.1_Missense_Mutation_p.P10A	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	107					cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						AAGACCTCCTCCACTGGCAAA	0.458		NaN											0	0	0	0.00308	0	8	83									
CYP51A1	1595	broad.mit.edu	37	7	91761093	91761093	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:91761093C>T	uc003ulm.3	-	2	448	c.286G>A	c.(286-288)GAG>AAG	p.E96K	CYP51A1_uc011khn.1_5'UTR|CYP51A1_uc003uln.3_Missense_Mutation_p.E33K|uc003ulo.1_5'Flank	NM_000786	NP_000777	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A,	90					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity				0	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	CTTACCTTCTCATATGCATTT	0.318		NaN											0	0	0	0.008291	0	10	29									
CASD1	64921	broad.mit.edu	37	7	94166908	94166908	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:94166908C>G	uc003uni.3	+	9	1195	c.968C>G	c.(967-969)TCT>TGT	p.S323C	CASD1_uc003unh.2_3'UTR|CASD1_uc003unj.3_Missense_Mutation_p.S323C	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	323	Helical; (Potential).					integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			TTCACTTTATCTATTATCGGA	0.358		NaN											0	0	0	0.003954	0	27	92									
TRRAP	8295	broad.mit.edu	37	7	98548583	98548583	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:98548583G>C	uc003upp.2	+	38	5607	c.5398G>C	c.(5398-5400)GAA>CAA	p.E1800Q	TRRAP_uc011kis.1_Missense_Mutation_p.E1782Q|TRRAP_uc003upr.2_Missense_Mutation_p.E1499Q	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1800					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCCCAATCCAGAAGGAGATAA	0.448		NaN											0	0	0	0.00361	0	69	238									
SMURF1	57154	broad.mit.edu	37	7	98649052	98649052	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:98649052G>C	uc003upu.1	-	8	1054	c.734C>G	c.(733-735)ACA>AGA	p.T245R	SMURF1_uc003upv.1_Missense_Mutation_p.T245R|SMURF1_uc003upt.2_Missense_Mutation_p.T245R	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	245	WW 1.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			GCCCTGGACTGTTGTTCTTTG	0.473		NaN											0	0	0	0.00361	0	48	96									
C7orf51	222950	broad.mit.edu	37	7	100087045	100087045	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:100087045C>G	uc003uvd.1	+	4	1860	c.1701C>G	c.(1699-1701)CTC>CTG	p.L567L	C7orf51_uc003uve.1_Silent_p.L349L	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	567										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ATGAGAGCCTCAAGGCTGGGG	0.647		NaN											0	0	0	0.006122	0	18	42									
GIGYF1	64599	broad.mit.edu	37	7	100283618	100283618	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:100283618C>G	uc003uwg.1	-	9	2042	c.1033G>C	c.(1033-1035)GAG>CAG	p.E345Q		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	345										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					CCTTCCTCCTCTAGCCCTTCG	0.687		NaN											0	0	0	0.001855	0	12	32									
GIGYF1	64599	broad.mit.edu	37	7	100283898	100283898	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:100283898C>G	uc003uwg.1	-	8	1862	c.853G>C	c.(853-855)GAG>CAG	p.E285Q		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	285										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TTGTCCTCCTCAAAGCCTTCA	0.607		NaN											0	0	0	0.001786	0	27	101									
GIGYF1	64599	broad.mit.edu	37	7	100284421	100284421	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:100284421C>G	uc003uwg.1	-	7	1554	c.545G>C	c.(544-546)GGA>GCA	p.G182A		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	182										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GCCAGCCCCTCCCTCCTCAAA	0.557		NaN											0	0	0	0.007413	0	17	51									
PRKAR2B	5577	broad.mit.edu	37	7	106797459	106797459	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:106797459G>C	uc003vdx.2	+	9	1124	c.949G>C	c.(949-951)GAA>CAA	p.E317Q		NM_002736	NP_002727	P31323	KAP3_HUMAN	cAMP-dependent protein kinase, regulatory	317	cAMP 2.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity			ovary(1)	1						TTTCATTGTAGAATCTGGAGA	0.343		NaN											0	0	0	0.00361	0	44	136									
GPR22	2845	broad.mit.edu	37	7	107115258	107115258	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:107115258G>A	uc003vef.2	+	3	2099	c.753G>A	c.(751-753)AAG>AAA	p.K251K	COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	251	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						CAGGGCAGAAGAAGAAAGCAA	0.363		NaN											0	0	0	0.004482	0	8	23									
SLC26A3	1811	broad.mit.edu	37	7	107430026	107430026	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:107430026G>C	uc003ver.2	-	6	889	c.678C>G	c.(676-678)CTC>CTG	p.L226L	SLC26A3_uc003ves.2_Silent_p.L191L	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	226					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						AAATGAATTTGAGTTGGGAAA	0.388		NaN											0	0	0	0.000248	0	3	34									
FOXP2	93986	broad.mit.edu	37	7	114282626	114282626	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:114282626C>T	uc003vhb.2	+	7	1311	c.937C>T	c.(937-939)CAT>TAT	p.H313Y	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.H338Y|FOXP2_uc003vha.2_Missense_Mutation_p.H221Y|FOXP2_uc011kmu.1_Missense_Mutation_p.H330Y|FOXP2_uc011kmv.1_Missense_Mutation_p.H312Y|FOXP2_uc010ljz.1_Missense_Mutation_p.H221Y|FOXP2_uc003vgx.2_Missense_Mutation_p.H313Y|FOXP2_uc003vhd.2_Missense_Mutation_p.H313Y|FOXP2_uc003vhc.2_Missense_Mutation_p.H338Y	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	313					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						ACCAATAACTCATCATTCCAT	0.393		NaN											0	0	0	0.002299	0	20	61									
PTPRZ1	5803	broad.mit.edu	37	7	121652699	121652699	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:121652699C>T	uc003vjy.2	+	12	3994	c.3599C>T	c.(3598-3600)CCA>CTA	p.P1200L	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1200	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ACTGTTCTTCCAGCTGTGCCC	0.378		NaN											0	0	0	0.00361	0	50	161									
FEZF1	389549	broad.mit.edu	37	7	121943827	121943827	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:121943827G>C	uc003vkd.2	-	1	739	c.665C>G	c.(664-666)TCC>TGC	p.S222C	FEZF1_uc003vkc.2_Missense_Mutation_p.S172C|uc010lko.1_RNA|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	222					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						CTGAGCCTGGGACAGGTCTTT	0.512		NaN											0	0	0	0.005443	0	27	87									
GPR37	2861	broad.mit.edu	37	7	124386968	124386968	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:124386968G>T	uc003vli.2	-	2	2104	c.1453C>A	c.(1453-1455)CAA>AAA	p.Q485K		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	485	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						CTCTCTAGTTGAATCTGCCGT	0.433		NaN											1	0	2.48779e-11	0.005443	3.09898e-11	26	102									
METTL2B	55798	broad.mit.edu	37	7	128119545	128119545	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:128119545C>T	uc003vnf.2	+	3	573	c.536C>T	c.(535-537)TCA>TTA	p.S179L	METTL2B_uc003vng.2_Missense_Mutation_p.S114L|METTL2B_uc011kop.1_Missense_Mutation_p.S43L	NM_018396	NP_060866	Q6P1Q9	MTL2B_HUMAN	methyltransferase like 2B	179							methyltransferase activity			skin(1)	1						CCTGGATCCTCAGCCACCTAC	0.428		NaN											0	0	0	0.00278	0	22	81									
ATP6V0A4	50617	broad.mit.edu	37	7	138447178	138447178	+	Missense_Mutation	SNP	G	G	A	rs144802156	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:138447178G>A	uc003vuf.2	-	6	657	c.419C>T	c.(418-420)ACG>ATG	p.T140M	ATP6V0A4_uc003vug.2_Missense_Mutation_p.T140M|ATP6V0A4_uc003vuh.2_Missense_Mutation_p.T140M	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	140	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						ATTGGTTTCCGTCTGAAAGTC	0.393		NaN											0	0	0	0.003163	0	15	43									
TRPV6	55503	broad.mit.edu	37	7	142571845	142571845	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:142571845G>A	uc003wbx.1	-	12	1719	c.1503C>T	c.(1501-1503)ATC>ATT	p.I501I	TRPV6_uc003wbw.1_Silent_p.I287I|TRPV6_uc010lou.1_Silent_p.I372I	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	501	Helical; (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CAAAGCCCAGGATGACCACAG	0.537		NaN											0	0	0	0.004482	0	6	24									
C7orf29	113763	broad.mit.edu	37	7	150028006	150028006	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:150028006G>A	uc003wgy.2	+	1	1069	c.513G>A	c.(511-513)GAG>GAA	p.E171E	LRRC61_uc003wgv.2_Intron|LRRC61_uc003wgx.2_Intron|LRRC61_uc003wgw.2_Intron	NM_138434	NP_612443	Q96FA7	CG029_HUMAN	hypothetical protein LOC113763	171										ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.011)			GCTTGCTGGAGAGCATGGGGC	0.632		NaN											0	0	0	0.000602	0	5	27									
ABCB8	11194	broad.mit.edu	37	7	150732745	150732745	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:150732745G>A	uc003wil.3	+	7	987	c.894G>A	c.(892-894)CTG>CTA	p.L298L	ABCB8_uc003wii.2_Silent_p.L318L|ABCB8_uc003wij.3_Silent_p.L281L|ABCB8_uc010lpw.1_Silent_p.L100L|ABCB8_uc010lpx.2_Silent_p.L281L|ABCB8_uc011kvd.1_Silent_p.L193L|ABCB8_uc003wim.3_Silent_p.L76L|ABCB8_uc003wik.3_Silent_p.L281L	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	298	ABC transmembrane type-1.|Helical; (Potential).					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGCTGCTGCTGATGGTGGCCA	0.652		NaN											0	0	0	0.002836	0	35	76									
GBX1	2636	broad.mit.edu	37	7	150864185	150864185	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:150864185C>T	uc011kvg.1	-	1	683	c.451G>A	c.(451-453)GAT>AAT	p.D151N		NM_001098834	NP_001092304	Q14549	GBX1_HUMAN	gastrulation brain homeo box 1	151	Pro-rich.					nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCAGCTCATCAGCTTCCAGC	0.542		NaN											0	0	0	0.00632	0	26	75									
PTPRN2	5799	broad.mit.edu	37	7	157387990	157387990	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:157387990C>A	uc003wno.2	-	17	2557	c.2436G>T	c.(2434-2436)AGG>AGT	p.R812S	PTPRN2_uc003wnp.2_Missense_Mutation_p.R795S|PTPRN2_uc003wnq.2_Missense_Mutation_p.R783S|PTPRN2_uc003wnr.2_Missense_Mutation_p.R774S|PTPRN2_uc011kwa.1_Missense_Mutation_p.R835S	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	812	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		ACGCGGGGTTCCTCGGGTCGT	0.532		NaN											1	0	4.7796e-09	0.004656	5.85258e-09	24	72									
NCAPG2	54892	broad.mit.edu	37	7	158437065	158437065	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:158437065G>C	uc003wnv.1	-	27	3441	c.3296C>G	c.(3295-3297)TCA>TGA	p.S1099*	NCAPG2_uc010lqu.1_Nonsense_Mutation_p.S844*|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Nonsense_Mutation_p.S1099*|NCAPG2_uc011kwe.1_Nonsense_Mutation_p.S1099*|NCAPG2_uc011kwc.1_Nonsense_Mutation_p.S553*|NCAPG2_uc011kwd.1_Nonsense_Mutation_p.S542*	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	1099					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		CCTCACTTTTGAGCTTTTATG	0.358		NaN											0	0	0	0.002299	0	21	145									
FGL1	2267	broad.mit.edu	37	8	17739572	17739572	+	Silent	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:17739572G>C	uc003wxx.2	-	4	504	c.180C>G	c.(178-180)GTC>GTG	p.V60V	FGL1_uc003wxy.2_Silent_p.V60V|FGL1_uc003wxz.2_Silent_p.V60V|FGL1_uc003wya.2_Silent_p.V60V|FGL1_uc003wyb.2_Silent_p.V60V|FGL1_uc003wyc.2_Silent_p.V60V|FGL1_uc003wyd.2_RNA|FGL1_uc003wye.2_Silent_p.V110V|FGL1_uc003wyf.2_Silent_p.V30V	NM_201553	NP_963847	Q08830	FGL1_HUMAN	fibrinogen-like 1 precursor	60	Potential.				signal transduction	fibrinogen complex	receptor binding				0				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		CAAGGAACTGGACTTCATTCT	0.478		NaN											0	0	0	0.002836	0	36	83									
LGI3	203190	broad.mit.edu	37	8	22011497	22011497	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:22011497C>G	uc003xav.2	-	5	767	c.478G>C	c.(478-480)GAC>CAC	p.D160H	LGI3_uc010ltu.2_Missense_Mutation_p.D136H	NM_139278	NP_644807	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	160					exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				ovary(1)	1				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		TTCAGGATGTCCAGGGGCCGG	0.572		NaN											0	0	0	0.003163	0	12	81									
C8orf58	541565	broad.mit.edu	37	8	22459311	22459311	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:22459311G>C	uc003xce.2	+	3	715	c.603G>C	c.(601-603)CAG>CAC	p.Q201H	C8orf58_uc011kzl.1_Missense_Mutation_p.Q201H|C8orf58_uc003xcf.2_Missense_Mutation_p.Q201H|KIAA1967_uc003xch.2_5'Flank	NM_001013842	NP_001013864	Q8NAV2	CH058_HUMAN	hypothetical protein LOC541565	201										skin(1)	1		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00563)|Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		TGCTGGAGCAGATGGCAAGGC	0.662		NaN											0	0	0	0.002222	0	41	98									
CDCA2	157313	broad.mit.edu	37	8	25343351	25343351	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:25343351C>T	uc003xep.1	+	11	1921	c.1442C>T	c.(1441-1443)TCA>TTA	p.S481L	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_Missense_Mutation_p.S481L|CDCA2_uc003xeq.1_Missense_Mutation_p.S466L|CDCA2_uc003xer.1_Missense_Mutation_p.S144L	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	481					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		GAGACCCTTTCAGGTAGTAAC	0.279		NaN											0	0	0	0.008291	0	11	30									
RAB11FIP1	80223	broad.mit.edu	37	8	37728859	37728859	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:37728859G>T	uc003xkm.1	-	4	3505	c.3461C>A	c.(3460-3462)TCA>TAA	p.S1154*	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Nonsense_Mutation_p.S483*|RAB11FIP1_uc003xko.1_Nonsense_Mutation_p.S483*|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	1154					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CTCCGAGGGTGAGACCCAGGC	0.542		NaN									OREG0018713	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.62699e-14	0.003163	3.28945e-14	15	199									
IKBKB	3551	broad.mit.edu	37	8	42179979	42179979	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:42179979G>A	uc003xow.1	+	19	2130	c.1953G>A	c.(1951-1953)CAG>CAA	p.Q651Q	IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Silent_p.Q428Q|IKBKB_uc003xox.1_Silent_p.Q372Q|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Silent_p.Q649Q|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Silent_p.Q592Q	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	651					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	AGAAGCGGCAGAAGGAGCTCT	0.567		NaN											0	0	0	0.006122	0	18	121									
POTEA	340441	broad.mit.edu	37	8	43197332	43197332	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:43197332C>G	uc003xpz.1	+	11	1264	c.1221C>G	c.(1219-1221)GTC>GTG	p.V407V	POTEA_uc003xqa.1_Silent_p.V361V	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	407										ovary(1)	1						TCTTACAGGTCAAAAGCCAAA	0.318		NaN											0	0	0	0.001168	0	4	44									
PRKDC	5591	broad.mit.edu	37	8	48711931	48711931	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:48711931C>T	uc003xqi.2	-	73	10194	c.10137G>A	c.(10135-10137)CAG>CAA	p.Q3379Q	PRKDC_uc003xqj.2_Silent_p.Q3379Q|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3379	FAT.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GGAATGCTCTCTGGTACAGAC	0.552		NaN						NHEJ					0	0	0	0.00361	0	59	93									
PRKDC	5591	broad.mit.edu	37	8	48801695	48801695	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:48801695C>A	uc003xqi.2	-	34	4217	c.4160G>T	c.(4159-4161)GGA>GTA	p.G1387V	PRKDC_uc003xqj.2_Missense_Mutation_p.G1387V|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1387					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CTGGACGTCTCCGATGTTGAA	0.463		NaN						NHEJ					1	0	2.4624e-09	0.008871	3.02032e-09	18	54									
MYBL1	4603	broad.mit.edu	37	8	67507965	67507965	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:67507965C>T	uc003xwj.2	-	6	947	c.540G>A	c.(538-540)TGG>TGA	p.W180*	MYBL1_uc003xwl.2_Nonsense_Mutation_p.W180*|MYBL1_uc003xwk.2_Nonsense_Mutation_p.W180*	NM_001080416	NP_001073885	P10243	MYBA_HUMAN	v-myb myeloblastosis viral oncogene homolog	180	HTH myb-type 3.|H-T-H motif (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)	3			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			TAGTAGAATTCCAATGATTTT	0.333		NaN											0	0	0	0.000248	0	4	6									
TRPA1	8989	broad.mit.edu	37	8	72975076	72975076	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:72975076G>C	uc003xza.2	-	6	940	c.765C>G	c.(763-765)ATC>ATG	p.I255M		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	255	ANK 6.|Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GGCACATTTTGATCATTTCCA	0.388		NaN											0	0	0	0.001855	0	13	71									
LRRCC1	85444	broad.mit.edu	37	8	86022358	86022358	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:86022358G>A	uc003ycw.2	+	3	473	c.319G>A	c.(319-321)GAA>AAA	p.E107K	LRRCC1_uc010lzz.1_RNA|LRRCC1_uc010maa.1_5'UTR|LRRCC1_uc003ycx.2_Missense_Mutation_p.E14K|LRRCC1_uc003ycy.2_Missense_Mutation_p.E87K	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	107	LRR 3.				cell division|mitosis	centriole|nucleus					0						aGGACTTGAAGAACTAATTAA	0.229		NaN											0	0	0	0.008291	0	9	52									
RIPK2	8767	broad.mit.edu	37	8	90798902	90798902	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:90798902G>A	uc003yee.2	+	9	1425	c.1111G>A	c.(1111-1113)GAT>AAT	p.D371N	RIPK2_uc003yef.2_Missense_Mutation_p.D234N	NM_003821	NP_003812	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	371					activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.0474)			TCAAGACAATGATTTTTTATC	0.338		NaN											0	0	0	0.001855	0	13	124									
PGCP	10404	broad.mit.edu	37	8	98155285	98155285	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:98155285C>T	uc003yhw.2	+	8	1459	c.1293C>T	c.(1291-1293)TTC>TTT	p.F431F		NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	431					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					AGTATTTCTTCTTCCATCACT	0.433		NaN											0	0	0	0.004007	0	16	37									
MTDH	92140	broad.mit.edu	37	8	98712020	98712020	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:98712020G>C	uc003yhz.2	+	7	1415	c.1087G>C	c.(1087-1089)GAT>CAT	p.D363H	MTDH_uc010mbf.2_Intron	NM_178812	NP_848927	Q86UE4	LYRIC_HUMAN	metadherin	363	Cytoplasmic (Potential).				lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			liver(1)|central_nervous_system(1)	2	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			TACCACTTCTGATTATCAGTG	0.333		NaN											0	0	0	0.008361	0	27	183									
NIPAL2	79815	broad.mit.edu	37	8	99234791	99234791	+	Silent	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:99234791C>A	uc003yil.1	-	5	730	c.474G>T	c.(472-474)GTG>GTT	p.V158V	NIPAL2_uc011lgw.1_5'UTR|NIPAL2_uc003yim.1_Silent_p.V158V	NM_024759	NP_079035	Q9H841	NPAL2_HUMAN	NIPA-like domain containing 2	158	Helical; (Potential).					integral to membrane					0						GAGCAAAGTTCACCAGTAAAT	0.363		NaN											1	0	3.52763e-06	0.00499	4.258e-06	17	130									
FBXO43	286151	broad.mit.edu	37	8	101153700	101153700	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:101153700G>C	uc003yjd.2	-	2	1495	c.782C>G	c.(781-783)TCT>TGT	p.S261C	FBXO43_uc003yje.2_Missense_Mutation_p.S227C|FBXO43_uc010mbp.1_Missense_Mutation_p.S261C	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	261					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			ATGTGTGATAGAGTCTTTAAA	0.378		NaN											0	0	0	0.002299	0	23	46									
ASAP1	50807	broad.mit.edu	37	8	131200403	131200403	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:131200403G>A	uc003yta.1	-	5	460	c.432C>T	c.(430-432)ATC>ATT	p.I144I	ASAP1_uc011liw.1_Silent_p.I137I	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	144					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						CCAAGGTGAAGATCACATTGT	0.323		NaN											0	0	0	0.00361	0	44	265									
PTK2	5747	broad.mit.edu	37	8	141754781	141754781	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:141754781G>A	uc003yvu.2	-	19	1834	c.1604C>T	c.(1603-1605)GCA>GTA	p.A535V	PTK2_uc003yvo.2_Missense_Mutation_p.A163V|PTK2_uc011ljq.1_Missense_Mutation_p.A230V|PTK2_uc003yvp.2_Missense_Mutation_p.A203V|PTK2_uc003yvq.2_Missense_Mutation_p.A61V|PTK2_uc003yvr.2_Missense_Mutation_p.A475V|PTK2_uc003yvs.2_Missense_Mutation_p.A535V|PTK2_uc003yvt.2_Missense_Mutation_p.A557V|PTK2_uc003yvv.2_Missense_Mutation_p.A435V|PTK2_uc011ljr.1_Missense_Mutation_p.A535V	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	535	Protein kinase.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			CTCTAGATATGCAAGAGCTGT	0.383		NaN											0	0	0	0.003271	0	30	110									
CYP11B2	1585	broad.mit.edu	37	8	143999073	143999073	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:143999073C>T	uc003yxk.1	-	1	187	c.184G>A	c.(184-186)GAG>AAG	p.E62K		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	62					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	TGCAGGTGCTCATAACCCTGC	0.637		NaN							Familial_Hyperaldosteronism_type_I				0	0	0	0.001168	0	6	55									
TOP1MT	116447	broad.mit.edu	37	8	144411579	144411579	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:144411579C>T	uc003yxz.2	-	3	320	c.301G>A	c.(301-303)GAT>AAT	p.D101N	TOP1MT_uc011lkd.1_Missense_Mutation_p.D3N|TOP1MT_uc011lke.1_Missense_Mutation_p.D3N|TOP1MT_uc010mfb.2_Missense_Mutation_p.D3N|TOP1MT_uc010mfd.1_5'UTR	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	101					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	TATTCATGATCTAACATCCTC	0.547		NaN											0	0	0	0.003163	0	15	121									
RHPN1	114822	broad.mit.edu	37	8	144463988	144463988	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:144463988G>A	uc003yyb.2	+	14	1780	c.1647G>A	c.(1645-1647)CTG>CTA	p.L549L		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	574	PDZ.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			CGGCTGGCCTGAAGGAGGGCG	0.677		NaN											0	0	0	0.00308	0	8	15									
ZNF16	7564	broad.mit.edu	37	8	146156262	146156262	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:146156262G>A	uc003zet.2	-	4	2098	c.1911C>T	c.(1909-1911)GCC>GCT	p.A637A	ZNF16_uc003zeu.2_Silent_p.A637A	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	637	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		GCTGACTGAAGGCTTTCCCAC	0.542		NaN											0	0	0	0.005443	0	28	77									
MPDZ	8777	broad.mit.edu	37	9	13224526	13224526	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:13224526G>A	uc010mia.1	-	3	297	c.240C>T	c.(238-240)CTC>CTT	p.L80L	MPDZ_uc010mhy.2_Silent_p.L80L|MPDZ_uc010mhz.2_Silent_p.L80L|MPDZ_uc011lmn.1_Silent_p.L80L|MPDZ_uc003zlb.3_Silent_p.L80L	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	80					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		CAGCTGGGCTGAGATGAGGAA	0.378		NaN											0	0	0	0.004656	0	27	33									
FREM1	158326	broad.mit.edu	37	9	14805073	14805073	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:14805073C>T	uc003zlm.2	-	19	3942	c.3352G>A	c.(3352-3354)GCC>ACC	p.A1118T	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1118	CSPG 7.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		AACTGGTCGGCAGTTGGTTCT	0.438		NaN											0	0	0	0.00361	0	50	60									
FREM1	158326	broad.mit.edu	37	9	14805089	14805089	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:14805089C>T	uc003zlm.2	-	19	3926	c.3336G>A	c.(3334-3336)CTG>CTA	p.L1112L	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1112	CSPG 7.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		GTTCTATCCTCAGATGCCTGG	0.408		NaN											0	0	0	0.00361	0	52	64									
RPS6	6194	broad.mit.edu	37	9	19376375	19376375	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:19376375C>G	uc003znv.1	-	6	708	c.666G>C	c.(664-666)GAG>GAC	p.E222D	RPS6_uc003znu.1_Missense_Mutation_p.E191D	NM_001010	NP_001001	P62753	RS6_HUMAN	ribosomal protein S6	222					endocrine pancreas development|glucose homeostasis|insulin receptor signaling pathway|positive regulation of apoptosis|rRNA processing|TOR signaling cascade|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding			ovary(1)	1		Colorectal(97;3.46e-05)|Myeloproliferative disorder(762;0.0255)		Lung(42;0.161)|LUSC - Lung squamous cell carcinoma(42;0.234)		CCTGGCGCTTCTCCTTAGCCT	0.448		NaN											0	0	0	0.002096	0	32	52									
CDKN2A	1029	broad.mit.edu	37	9	21971003	21971003	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:21971003C>T	uc003zpk.2	-	2	567	c.355G>A	c.(355-357)GAG>AAG	p.E119K	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.*174*	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	119	ANK 4.		E -> Q (in a biliary tract tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.E119Q(2)|p.E119*(2)|p.A118fs*10(1)|p.A118fs*27(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCCAGCTCCTCAGCCAGGTCC	0.726		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			0	0	0	0.001855	0	14	21									
CDKN2A	1029	broad.mit.edu	37	9	21971036	21971036	+	Missense_Mutation	SNP	C	C	T	rs121913381		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:21971036C>T	uc003zpk.2	-	2	534	c.322G>A	c.(322-324)GAT>AAT	p.D108N	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.R163Q	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	108			D -> Y (in a head and neck tumor).|D -> H (in a bladder tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.D108Y(14)|p.?(13)|p.D108H(9)|p.D108N(5)|p.H83fs*2(2)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCCCAGGCATCGCGCACGTCC	0.741		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			0	0	0	0.000978	0	10	17									
PLAA	9373	broad.mit.edu	37	9	26905860	26905860	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:26905860C>G	uc003zqd.2	-	14	2462	c.2037G>C	c.(2035-2037)CAG>CAC	p.Q679H		NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	679	PUL.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		GTGATTCCCTCTGGGACATCA	0.443		NaN											0	0	0	0.001523	0	21	37									
NOL6	65083	broad.mit.edu	37	9	33467733	33467733	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:33467733C>T	uc003zsz.2	-	12	1659	c.1558G>A	c.(1558-1560)GCT>ACT	p.A520T	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zsy.2_5'Flank|NOL6_uc003zta.2_Missense_Mutation_p.A520T|NOL6_uc010mjv.2_Missense_Mutation_p.A517T|NOL6_uc011lob.1_Missense_Mutation_p.A468T|NOL6_uc003ztb.1_Missense_Mutation_p.A520T	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	520					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		TTCAGCCGAGCCCCCAGGCCC	0.647		NaN											0	0	0	0.000602	0	4	37									
DCAF12	25853	broad.mit.edu	37	9	34107359	34107359	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:34107359C>T	uc003ztt.2	-	3	880	c.538G>A	c.(538-540)GAT>AAT	p.D180N		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	180						centrosome|CUL4 RING ubiquitin ligase complex					0						AAACTTACATCTCCTACACAC	0.502		NaN											0	0	0	0.00632	0	29	73									
RG9MTD3	158234	broad.mit.edu	37	9	37776350	37776350	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:37776350C>T	uc004aai.2	+	8	869	c.792C>T	c.(790-792)GTC>GTT	p.V264V	RG9MTD3_uc011lqo.1_Silent_p.V213V|RG9MTD3_uc011lqp.1_Silent_p.V186V|RG9MTD3_uc011lqq.1_Silent_p.V153V|RG9MTD3_uc004aaj.2_RNA|RG9MTD3_uc004aak.2_Silent_p.V169V	NM_144964	NP_659401	Q6PF06	RG9D3_HUMAN	RNA (guanine-9-) methyltransferase domain	264							methyltransferase activity				0				GBM - Glioblastoma multiforme(29;0.00817)|Lung(182;0.226)		AATACATGGTCAGAAACCAGA	0.428		NaN											0	0	0	0.008291	0	11	12									
MAMDC2	256691	broad.mit.edu	37	9	72840940	72840940	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:72840940G>C	uc004ahm.2	+	14	2670	c.2053G>C	c.(2053-2055)GAG>CAG	p.E685Q	MAMDC2_uc004ahn.2_RNA|uc004ahq.1_Intron	NM_153267	NP_694999	Q7Z304	MAMC2_HUMAN	MAM domain containing 2 precursor	685						endoplasmic reticulum|membrane				central_nervous_system(1)|pancreas(1)	2						AAATGAAATTGAGTATTAAGA	0.299		NaN											0	0	0	0.004482	0	7	16									
SMC5	23137	broad.mit.edu	37	9	72962046	72962046	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:72962046G>C	uc004ahr.2	+	20	2750	c.2633G>C	c.(2632-2634)AGA>ACA	p.R878T	SMC5_uc011lry.1_Missense_Mutation_p.R23T	NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	878					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						GAAAGATCAAGAGCTTCCTGC	0.418		NaN											0	0	0	0.004482	0	7	23									
C9orf95	54981	broad.mit.edu	37	9	77683978	77683978	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:77683978C>G	uc004aju.2	-	7	1028	c.430G>C	c.(430-432)GAT>CAT	p.D144H	C9orf95_uc004ajs.3_Missense_Mutation_p.D148H|C9orf95_uc004ajr.3_Missense_Mutation_p.D144H|C9orf95_uc004ajt.3_Missense_Mutation_p.D120H	NM_017881	NP_060351	Q9NWW6	NRK1_HUMAN	nicotinamide riboside kinase 1 isoform 1	144					pyridine nucleotide biosynthetic process		ATP binding|metal ion binding|ribosylnicotinamide kinase activity				0						ACATGGCCATCAAAGTATCCC	0.413		NaN											0	0	0	0.003163	0	15	70									
GKAP1	80318	broad.mit.edu	37	9	86368211	86368211	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:86368211C>T	uc004amy.2	-	9	1298	c.802G>A	c.(802-804)GAA>AAA	p.E268K	GKAP1_uc004amz.2_Missense_Mutation_p.E217K	NM_025211	NP_079487	Q5VSY0	GKAP1_HUMAN	G kinase anchoring protein 1 isoform a	268	Potential.				signal transduction	Golgi apparatus					0						TTCTGGATTTCAGCATCTTTC	0.323		NaN											0	0	0	0.007413	0	19	55									
STX17	55014	broad.mit.edu	37	9	102722413	102722413	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:102722413C>T	uc004bal.3	+	6	694	c.558C>T	c.(556-558)GTC>GTT	p.V186V	STX17_uc010msx.2_RNA|STX17_uc011lvd.1_RNA	NM_017919	NP_060389	P56962	STX17_HUMAN	syntaxin 17	186	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum|integral to membrane|nucleolus	SNAP receptor activity			large_intestine(1)	1		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				GCCAACTGGTCACTGACTTCT	0.333		NaN											0	0	0	0.002445	0	29	71									
PTPN3	5774	broad.mit.edu	37	9	112144604	112144604	+	Missense_Mutation	SNP	C	C	T	rs147420952	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:112144604C>T	uc004bed.2	-	24	2618	c.2506G>A	c.(2506-2508)GAG>AAG	p.E836K	PTPN3_uc004beb.2_Missense_Mutation_p.E705K|PTPN3_uc004bec.2_Missense_Mutation_p.E660K|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Missense_Mutation_p.E791K|PTPN3_uc011lwh.1_Missense_Mutation_p.E682K|PTPN3_uc011lwd.1_Missense_Mutation_p.E304K|PTPN3_uc011lwe.1_Missense_Mutation_p.E549K|PTPN3_uc011lwf.1_Missense_Mutation_p.E504K	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	836	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						AGGACGGGCTCGCTGTCCACT	0.537		NaN											0	0	0	0.00308	0	8	26									
PTPN3	5774	broad.mit.edu	37	9	112144707	112144707	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:112144707C>T	uc004bed.2	-	24	2515	c.2403G>A	c.(2401-2403)GTG>GTA	p.V801V	PTPN3_uc004beb.2_Silent_p.V670V|PTPN3_uc004bec.2_Silent_p.V625V|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Silent_p.V756V|PTPN3_uc011lwh.1_Silent_p.V647V|PTPN3_uc011lwd.1_Silent_p.V269V|PTPN3_uc011lwe.1_Silent_p.V514V|PTPN3_uc011lwf.1_Silent_p.V469V	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	801	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						GGAGATGTGTCACTGTGTGTT	0.572		NaN											0	0	0	0.00245	0	14	34									
SUSD1	64420	broad.mit.edu	37	9	114904620	114904620	+	Missense_Mutation	SNP	G	G	A	rs113511367	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:114904620G>A	uc004bfu.2	-	5	727	c.686C>T	c.(685-687)TCC>TTC	p.S229F	SUSD1_uc010mui.2_Missense_Mutation_p.S229F|SUSD1_uc010muj.2_Missense_Mutation_p.S229F	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	229	Sushi 1.|Extracellular (Potential).					integral to membrane	calcium ion binding				0						TAATTTTGGGGACTCCCATGT	0.418		NaN											0	0	0	0.00361	0	61	111									
PRPF4	9128	broad.mit.edu	37	9	116053935	116053935	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:116053935G>C	uc004bgx.2	+	14	1614	c.1564G>C	c.(1564-1566)GAA>CAA	p.E522Q	PRPF4_uc004bgy.2_Missense_Mutation_p.E521Q	NM_004697	NP_004688	O43172	PRP4_HUMAN	PRP4 pre-mRNA processing factor 4 homolog	522						Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			ovary(2)|pancreas(1)	3						GTGGATGGCTGAATAGATGAC	0.453		NaN											0	0	0	0.007413	0	20	17									
NR6A1	2649	broad.mit.edu	37	9	127289083	127289083	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:127289083C>T	uc004bor.1	-	8	1354	c.1176G>A	c.(1174-1176)ATG>ATA	p.M392I	NR6A1_uc004boq.1_Missense_Mutation_p.M387I|NR6A1_uc010mwq.1_Missense_Mutation_p.M388I	NM_033334	NP_201591	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	392					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						TAATTGCTTTCATGCAAGCAT	0.498		NaN											0	0	0	0.005524	0	35	99									
NR6A1	2649	broad.mit.edu	37	9	127289100	127289100	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:127289100C>A	uc004bor.1	-	8	1337	c.1159G>T	c.(1159-1161)GAG>TAG	p.E387*	NR6A1_uc004boq.1_Nonsense_Mutation_p.E382*|NR6A1_uc010mwq.1_Nonsense_Mutation_p.E383*	NM_033334	NP_201591	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	387					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						GCATACTCCTCGTTGCTGACC	0.498		NaN											1	0	1.07637e-12	0.004878	1.34313e-12	38	93									
MAPKAP1	79109	broad.mit.edu	37	9	128347847	128347847	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:128347847C>T	uc004bpv.2	-	5	991	c.658G>A	c.(658-660)GAG>AAG	p.E220K	MAPKAP1_uc011lzt.1_Missense_Mutation_p.E23K|MAPKAP1_uc010mwz.2_RNA|MAPKAP1_uc011lzu.1_Missense_Mutation_p.E23K|MAPKAP1_uc011lzv.1_Missense_Mutation_p.E23K|MAPKAP1_uc004bpw.2_Missense_Mutation_p.E28K|MAPKAP1_uc004bpx.2_Missense_Mutation_p.E28K|MAPKAP1_uc004bpy.2_Missense_Mutation_p.E220K|MAPKAP1_uc004bpz.2_Missense_Mutation_p.E220K|MAPKAP1_uc010mxa.2_RNA|MAPKAP1_uc010mxb.1_Missense_Mutation_p.E23K|MAPKAP1_uc004bqa.2_Missense_Mutation_p.E220K|MAPKAP1_uc010mxc.1_Missense_Mutation_p.E92K	NM_001006617	NP_001006618	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated	220					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			ovary(2)|lung(2)	4						AGCTTCGGCTCCCGTCCTTCG	0.542		NaN											0	0	0	0.001786	0	29	58									
ENG	2022	broad.mit.edu	37	9	130580997	130580997	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:130580997G>A	uc004bsj.3	-	11	1839	c.1426C>T	c.(1426-1428)CAG>TAG	p.Q476*	ENG_uc011mam.1_Nonsense_Mutation_p.Q287*|ENG_uc004bsk.3_Nonsense_Mutation_p.Q476*|uc004bsl.1_Intron	NM_001114753	NP_001108225	P17813	EGLN_HUMAN	endoglin isoform 1 precursor	476	Ser/Thr-rich.|Extracellular (Potential).				artery morphogenesis|BMP signaling pathway|cell adhesion|cell chemotaxis|central nervous system vasculogenesis|chronological cell aging|detection of hypoxia|extracellular matrix disassembly|heart looping|negative regulation of endothelial cell proliferation|negative regulation of nitric-oxide synthase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of protein autophosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|patterning of blood vessels|positive regulation of BMP signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of systemic arterial blood pressure|positive regulation of transcription from RNA polymerase II promoter|regulation of cell adhesion|regulation of cell proliferation|regulation of transcription, DNA-dependent|regulation of transforming growth factor beta receptor signaling pathway|smooth muscle tissue development|transforming growth factor beta receptor signaling pathway|venous blood vessel morphogenesis|wound healing	cell surface|external side of plasma membrane|extracellular space|membrane fraction	activin binding|galactose binding|glycosaminoglycan binding|protein homodimerization activity|transforming growth factor beta binding|transforming growth factor beta receptor activity|transforming growth factor beta receptor, cytoplasmic mediator activity|transmembrane receptor activity|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding				0						CCAGGTACCTGCACAAAGCTC	0.612		NaN							Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				0	0	0	0.00361	0	52	79									
LCN2	3934	broad.mit.edu	37	9	130914210	130914210	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:130914210C>T	uc004bto.1	+	4	454	c.381C>T	c.(379-381)CTC>CTT	p.L127L	LCN2_uc011map.1_Silent_p.L127L	NM_005564	NP_005555	P80188	NGAL_HUMAN	lipocalin 2 precursor	127					apoptosis|innate immune response|regulation of apoptosis|siderophore transport		iron ion binding|transporter activity				0						CGAGTTACCTCGTCCGAGTGG	0.567		NaN											0	0	0	0.005443	0	27	57									
CERCAM	51148	broad.mit.edu	37	9	131190687	131190687	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:131190687C>T	uc004buz.3	+	6	1271	c.873C>T	c.(871-873)ATC>ATT	p.I291I	CERCAM_uc004buy.1_Silent_p.I213I|CERCAM_uc010mxz.2_Silent_p.I213I|CERCAM_uc010mya.1_Silent_p.I132I	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	291					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						TCCACCTGATCTTAGAAGCAC	0.612		NaN											0	0	0	0.000602	0	5	26									
SPTAN1	6709	broad.mit.edu	37	9	131369932	131369932	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:131369932G>T	uc004bvl.3	+	32	4209	c.4096G>T	c.(4096-4098)GAG>TAG	p.E1366*	SPTAN1_uc004bvm.3_Nonsense_Mutation_p.E1366*|SPTAN1_uc004bvn.3_Nonsense_Mutation_p.E1346*	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1366	Spectrin 15.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GTCCTCAGATGAGCTAGCCAA	0.542		NaN											1	0	1.78839e-46	0.00361	2.29321e-46	73	94									
NUP188	23511	broad.mit.edu	37	9	131768878	131768878	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:131768878C>G	uc004bws.1	+	44	5193	c.5171C>G	c.(5170-5172)TCT>TGT	p.S1724C		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1724					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						AAGTCCACCTCTCTCTCCAAA	0.637		NaN									OREG0019528	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003214	0	46	45									
TSC1	7248	broad.mit.edu	37	9	135776115	135776115	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:135776115G>C	uc004cca.2	-	20	2846	c.2612C>G	c.(2611-2613)TCA>TGA	p.S871*	TSC1_uc004ccb.3_Nonsense_Mutation_p.S870*|TSC1_uc011mcq.1_Nonsense_Mutation_p.S820*|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	871	Potential.				activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		TGTGGTATCTGAGTGCTTGTT	0.527		NaN	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				0	0	0	0.00361	0	54	82									
RALGDS	5900	broad.mit.edu	37	9	135979668	135979668	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:135979668C>G	uc004cco.2	-	10	1673	c.1653G>C	c.(1651-1653)CAG>CAC	p.Q551H	RALGDS_uc004ccn.2_5'Flank|RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Missense_Mutation_p.Q539H|RALGDS_uc004ccr.2_Missense_Mutation_p.Q550H|RALGDS_uc011mcv.1_Missense_Mutation_p.Q522H|RALGDS_uc004ccs.2_Missense_Mutation_p.Q496H|RALGDS_uc011mcw.1_Missense_Mutation_p.Q622H|RALGDS_uc004ccv.1_Missense_Mutation_p.Q320H|RALGDS_uc004ccu.1_Missense_Mutation_p.Q320H	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	551	Ras-GEF.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		TCGGCCGTTTCTGGGCTCTCT	0.662		NaN	T	CIITA	PMBL|Hodgkin Lymphona|								0	0	0	0.004007	0	16	34									
KCNT1	57582	broad.mit.edu	37	9	138657499	138657499	+	Silent	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:138657499G>A	uc011mdq.1	+	13	1304	c.1230G>A	c.(1228-1230)ACG>ACA	p.T410T	KCNT1_uc011mdr.1_Silent_p.T237T|KCNT1_uc010nbf.2_Silent_p.T365T|KCNT1_uc004cgo.1_Silent_p.T159T	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	410						membrane	binding|calcium-activated potassium channel activity	p.T410M(1)		large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		TGTGCCCCACGGAGATGGATG	0.657		NaN											0	0	0	0.000602	0	5	10									
NOTCH1	4851	broad.mit.edu	37	9	139390629	139390629	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:139390629G>A	uc004chz.2	-	34	7562	c.7562C>T	c.(7561-7563)TCC>TTC	p.S2521F		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2521	Poly-Ser.|Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.W2521*(1)		haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGACGAGCTGGACCACTGGTC	0.662		NaN	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			0	0	0	0.000978	0	8	33									
NPDC1	56654	broad.mit.edu	37	9	139937506	139937506	+	Silent	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:139937506C>T	uc004ckt.2	-	2	367	c.132G>A	c.(130-132)GGG>GGA	p.G44G	NPDC1_uc004ckr.2_Silent_p.G44G|NPDC1_uc004cks.2_Silent_p.G122G|NPDC1_uc004cku.2_Silent_p.G44G	NM_015392	NP_056207	Q9NQX5	NPDC1_HUMAN	neural proliferation, differentiation and	44						integral to membrane					0	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		AGTCCAGGCTCCCGGGACAGG	0.697		NaN											0	0	0	0.001168	0	4	23									
TLR7	51284	broad.mit.edu	37	X	12903875	12903875	+	Missense_Mutation	SNP	C	C	A	rs143823510		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:12903875C>A	uc004cvc.2	+	3	387	c.248C>A	c.(247-249)GCG>GAG	p.A83E		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	83	Extracellular (Potential).|LRR 2.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity	p.A83A(1)		ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	ATCTCCCCAGCGTCCTTTCAC	0.483		NaN											1	0	1.46156e-29	0.00361	1.86582e-29	51	38									
REPS2	9185	broad.mit.edu	37	X	17040287	17040287	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:17040287G>A	uc004cxv.1	+	3	610	c.439G>A	c.(439-441)GAG>AAG	p.E147K	REPS2_uc004cxw.1_Missense_Mutation_p.E147K|REPS2_uc011miw.1_Missense_Mutation_p.E7K	NM_004726	NP_004717	Q8NFH8	REPS2_HUMAN	RALBP1 associated Eps domain containing 2	147	EH 1.				epidermal growth factor receptor signaling pathway|protein complex assembly	cytoplasm	calcium ion binding|protein binding			skin(2)|central_nervous_system(1)	3	Hepatocellular(33;0.183)					GAATGATGGTGAGATACGATT	0.388		NaN											0	0	0	0.00361	0	107	57									
NHS	4810	broad.mit.edu	37	X	17744900	17744900	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:17744900C>G	uc004cxx.2	+	6	2949	c.2611C>G	c.(2611-2613)CTT>GTT	p.L871V	NHS_uc011mix.1_Missense_Mutation_p.L892V|NHS_uc004cxy.2_Missense_Mutation_p.L715V|NHS_uc004cxz.2_Missense_Mutation_p.L694V|NHS_uc004cya.2_Missense_Mutation_p.L594V	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	871						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					GAAGCTGCCTCTTGATTTCGC	0.473		NaN											0	0	0	0.006122	0	19	53									
FAM48B2	170067	broad.mit.edu	37	X	24329257	24329257	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:24329257C>T	uc011mjw.1	-	1	2176	c.2176G>A	c.(2176-2178)GCT>ACT	p.A726T		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	726	Gln-rich.										0						AACACAGCAGCCTGGGGCTGG	0.607		NaN											0	0	0	0.000602	0	5	2									
ZNF41	7592	broad.mit.edu	37	X	47307191	47307191	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:47307191C>T	uc004dhs.3	-	4	2171	c.2104G>A	c.(2104-2106)GAG>AAG	p.E702K	ZNF41_uc004dhu.3_Missense_Mutation_p.E694K|ZNF41_uc004dht.3_Missense_Mutation_p.E574K|ZNF41_uc004dhv.3_Missense_Mutation_p.E670K|ZNF41_uc004dhw.3_Missense_Mutation_p.E662K|ZNF41_uc004dhy.3_Missense_Mutation_p.E660K|ZNF41_uc004dhx.3_Missense_Mutation_p.E660K|ZNF41_uc011mlm.1_Missense_Mutation_p.E574K	NM_153380	NP_700359	P51814	ZNF41_HUMAN	zinc finger protein 41	702						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3		all_lung(315;0.000129)				TTGGGCTTCTCACCTGTGTGG	0.438		NaN											0	0	0	0.002836	0	33	42									
GPR173	54328	broad.mit.edu	37	X	53106214	53106214	+	Silent	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:53106214C>G	uc004dru.2	+	2	669	c.411C>G	c.(409-411)CTC>CTG	p.L137L		NM_018969	NP_061842	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	137	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GCATGACACTCTGGACATGCG	0.587		NaN											0	0	0	0.005443	0	28	14									
UBQLN2	29978	broad.mit.edu	37	X	56590553	56590553	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:56590553G>C	uc004dus.2	+	1	482	c.247G>C	c.(247-249)GAT>CAT	p.D83H	UBQLN2_uc011moq.1_Missense_Mutation_p.D83H	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	83	Ubiquitin-like.					cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						AATCTTAAAAGATCAAGATAC	0.483		NaN											0	0	0	0.008291	0	11	25									
MED12	9968	broad.mit.edu	37	X	70339888	70339888	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:70339888G>C	uc004dyy.2	+	4	620	c.421G>C	c.(421-423)GAG>CAG	p.E141Q	MED12_uc011mpq.1_Missense_Mutation_p.E141Q|MED12_uc004dyz.2_Missense_Mutation_p.E141Q|MED12_uc004dza.2_5'UTR	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	141					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TAAGAAGGAAGAGGTGTTTGG	0.468		NaN											0	0	0	0.004289	0	38	34									
ATRX	546	broad.mit.edu	37	X	76888758	76888758	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:76888758G>C	uc004ecp.3	-	19	5303	c.5071C>G	c.(5071-5073)CAA>GAA	p.Q1691E	ATRX_uc004ecq.3_Missense_Mutation_p.Q1653E|ATRX_uc004eco.3_Missense_Mutation_p.Q1476E	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1691	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTCCTTCCTTGAGCAAGATTT	0.393		NaN	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						0	0	0	0.00361	0	168	127									
TGIF2LX	90316	broad.mit.edu	37	X	89177499	89177499	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:89177499G>A	uc004efe.2	+	2	464	c.415G>A	c.(415-417)GAG>AAG	p.E139K		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	139						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GCAGAGCACCGAGGCGTCTGT	0.582		NaN											0	0	0	0.001786	0	30	33									
NOX1	27035	broad.mit.edu	37	X	100118475	100118475	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:100118475G>A	uc004egj.2	-	3	457	c.251C>T	c.(250-252)TCA>TTA	p.S84L	uc010nnf.2_Intron|NOX1_uc004egl.3_Missense_Mutation_p.S84L|NOX1_uc010nne.2_Intron	NM_007052	NP_008983	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1 isoform long	84	Cytoplasmic (Potential).|Ferric oxidoreductase.				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			ovary(1)	1						GGGACTCACTGAGCAGGTGCC	0.532		NaN											0	0	0	0.00308	0	6	21									
TIMM8A	1678	broad.mit.edu	37	X	100603636	100603636	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:100603636G>C	uc004ehd.2	-	1	322	c.17C>G	c.(16-18)TCT>TGT	p.S6C	TIMM8A_uc011mri.1_Missense_Mutation_p.S6C	NM_004085	NP_004076	O60220	TIM8A_HUMAN	translocase of inner mitochondrial membrane 8	6					nervous system development|protein import into mitochondrial inner membrane|transmembrane transport	mitochondrial inner membrane|mitochondrial intermembrane space protein transporter complex	protein binding				0						CGCGGAGGAAGAGGAGGAGGA	0.607		NaN											0	0	0	0.00333	0	21	29									
RGAG1	57529	broad.mit.edu	37	X	109695911	109695911	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:109695911C>G	uc004eor.1	+	3	2312	c.2066C>G	c.(2065-2067)TCT>TGT	p.S689C	RGAG1_uc011msr.1_Missense_Mutation_p.S689C	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	689										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GCCACAGTCTCTGGAGGGATG	0.512		NaN											0	0	0	0.005443	0	26	21									
UTP14A	10813	broad.mit.edu	37	X	129058892	129058892	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:129058892G>C	uc004euz.2	+	12	1498	c.1470G>C	c.(1468-1470)GAG>GAC	p.E490D	UTP14A_uc011mup.1_Missense_Mutation_p.E438D|UTP14A_uc011muq.1_Missense_Mutation_p.E436D	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	490					rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2						TCCAGAGAGAGGAACCTGCCC	0.478		NaN											0	0	0	0.005524	0	35	99									
HTATSF1	27336	broad.mit.edu	37	X	135593382	135593382	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:135593382G>T	uc004ezw.2	+	10	1900	c.1478G>T	c.(1477-1479)GGA>GTA	p.G493V	HTATSF1_uc004ezx.2_Missense_Mutation_p.G493V	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	493	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CCCGTAAGAGGATCTGAAGAG	0.443		NaN											1	0	1.99824e-07	0.00499	2.42619e-07	18	23									
GABRE	2564	broad.mit.edu	37	X	151138714	151138714	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:151138714G>A	uc004ffi.2	-	2	271	c.217C>T	c.(217-219)CGC>TGC	p.R73C	GABRE_uc011myd.1_RNA|GABRE_uc011mye.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	73	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTCAGGATGCGAGAGGCTTCT	0.547		NaN											0	0	0	0.004656	0	24	101									
FLNA	2316	broad.mit.edu	37	X	153599343	153599343	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:153599343G>C	uc004fkk.2	-	2	520	c.271C>G	c.(271-273)CGC>GGC	p.R91G	FLNA_uc010nuu.1_Missense_Mutation_p.R91G	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	91	CH 1.|Actin-binding.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTGTGCTTGCGGTGCATCTTC	0.607		NaN											0	0	0	0.003163	0	14	9									
EIF4G2	1982	broad.mit.edu	37	11	10823639	10823640	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:10823639_10823640delTG	uc001mjc.2	-	13	1672_1673	c.1255_1256delCA	c.(1255-1257)CAAfs	p.Q419fs	EIF4G2_uc001mjb.2_Frame_Shift_Del_p.Q213fs|EIF4G2_uc009ygf.2_Frame_Shift_Del_p.Q213fs|EIF4G2_uc001mjd.2_Frame_Shift_Del_p.Q419fs|EIF4G2_uc001mjf.1_Frame_Shift_Del_p.Q213fs|SNORD97_uc009yge.2_5'Flank	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	419					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AAACTGCGATTGTGTGGGAGGC	0.431		NaN											NaN	NaN	NaN	NaN	NaN	15	109	---	---							
ARID2	196528	broad.mit.edu	37	12	46240637	46240638	+	Splice_Site	INS	-	-	GCTT			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			-	GCTT	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:46240637_46240638insGCTT	uc001ros.1	+	12	1499	c.1499_splice	c.e12-1	p.A500_splice	ARID2_uc001ror.2_Splice_Site_p.A500_splice|ARID2_uc009zkg.1_Splice_Site|ARID2_uc009zkh.1_Splice_Site_p.A127_splice	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTTTTTCTTTAGCTTCCAGAGC	0.351		NaN											NaN	NaN	NaN	NaN	NaN	8	70	---	---							
TUSC5	286753	broad.mit.edu	37	17	1183661	1183661	+	Frame_Shift_Del	DEL	C	C	-			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:1183661delC	uc002fsi.1	+	1	705	c.366delC	c.(364-366)ATCfs	p.I122fs		NM_172367	NP_758955	Q8IXB3	TUSC5_HUMAN	LOST1	122	Helical; (Potential).				response to biotic stimulus	integral to membrane				skin(2)	2				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TCAACCTCATCCCCCTCATCA	0.617		NaN											NaN	NaN	NaN	NaN	NaN	56	112	---	---							
QRICH2	84074	broad.mit.edu	37	17	74283954	74283955	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:74283954_74283955delCC	uc002jrd.1	-	6	3504_3505	c.3324_3325delGG	c.(3322-3327)CTGGAAfs	p.L1108fs	QRICH2_uc010wsz.1_Frame_Shift_Del_p.L1034fs|QRICH2_uc010dgw.1_5'UTR	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1108_1109	Potential.						protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						CCTTCCCCTTCCAGGATCCTCT	0.559		NaN											NaN	NaN	NaN	NaN	NaN	34	96	---	---							
SLC14A1	6563	broad.mit.edu	37	18	43310353	43310353	+	Frame_Shift_Del	DEL	C	C	-			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:43310353delC	uc010xcn.1	+	4	387	c.68delC	c.(67-69)TCGfs	p.S23fs	SLC14A1_uc010dnk.2_Frame_Shift_Del_p.S79fs|SLC14A1_uc002lbf.3_Frame_Shift_Del_p.S23fs|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Intron|SLC14A1_uc002lbh.3_Intron|SLC14A1_uc002lbi.3_Intron|SLC14A1_uc002lbj.3_Frame_Shift_Del_p.S79fs|SLC14A1_uc002lbk.3_Frame_Shift_Del_p.S23fs	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	23						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						AACCAGGTTTCGCCATGTCAA	0.507		NaN											NaN	NaN	NaN	NaN	NaN	35	77	---	---							
OBSL1	23363	broad.mit.edu	37	2	220435169	220435170	+	Frame_Shift_Ins	INS	-	-	TGCT			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:220435169_220435170insTGCT	uc010fwk.2	-	1	842_843	c.785_786insAGCA	c.(784-786)CACfs	p.H262fs	OBSL1_uc010fwl.1_5'Flank|OBSL1_uc002vmi.2_Frame_Shift_Ins_p.H262fs|OBSL1_uc002vmj.2_Intron|INHA_uc002vmk.1_5'Flank	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	262	Ig-like 3.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		GGAACTTGGCGTGCTTGCCCTC	0.723		NaN											NaN	NaN	NaN	NaN	NaN	19	89	---	---							
FAT1	2195	broad.mit.edu	37	4	187510105	187510115	+	Frame_Shift_Del	DEL	CAGGCATGTCT	CAGGCATGTCT	-			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:187510105_187510115delCAGGCATGTCT	uc003izf.2	-	27	13586_13596	c.13398_13408delAGACATGCCTG	c.(13396-13410)AGAGACATGCCTGCCfs	p.R4466fs	FAT1_uc010isn.2_Frame_Shift_Del_p.R113fs|FAT1_uc003ize.2_Frame_Shift_Del_p.R357fs	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4466_4470	Cytoplasmic (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CTACCCGCGGCAGGCATGTCTCTAGGAGGGT	0.502		NaN								HNSCC(5;0.00058)			NaN	NaN	NaN	NaN	NaN	16	295	---	---							
SLC12A2	6558	broad.mit.edu	37	5	127514329	127514330	+	Frame_Shift_Ins	INS	-	-	A			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:127514329_127514330insA	uc003kus.2	+	22	3212_3213	c.3048_3049insA	c.(3046-3051)CAGAAAfs	p.Q1016fs	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Frame_Shift_Ins_p.Q1000fs	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	1016_1017	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	CACAGTTTCAGAAAAAACAAGG	0.307		NaN											NaN	NaN	NaN	NaN	NaN	8	77	---	---							
KDM6A	7403	broad.mit.edu	37	X	44942739	44942739	+	Frame_Shift_Del	DEL	C	C	-			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:44942739delC	uc004dge.3	+	23	3694	c.3319delC	c.(3319-3321)CCTfs	p.P1107fs	KDM6A_uc011mkz.1_Frame_Shift_Del_p.P1159fs|KDM6A_uc011mla.1_Frame_Shift_Del_p.P1062fs|KDM6A_uc011mlb.1_Frame_Shift_Del_p.P1114fs|KDM6A_uc011mlc.1_Frame_Shift_Del_p.P811fs|KDM6A_uc011mld.1_Frame_Shift_Del_p.P746fs	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1107	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						GACTAAACTTCCTGCTTTTGT	0.403		NaN	D|N|F|S		renal|oesophageal SCC|MM								NaN	NaN	NaN	NaN	NaN	29	10	---	---							
