Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ISG15	9636	broad.mit.edu	37	1	949726	949726	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:949726C>G	uc001acj.3	+	2	473	c.366C>G	c.(364-366)TTC>TTG	p.F122L		NM_005101	NP_005092	P05161	ISG15_HUMAN	ISG15 ubiquitin-like modifier precursor	122	Ubiquitin-like 2.				cell-cell signaling|interspecies interaction between organisms|ISG15-protein conjugation|negative regulation of type I interferon production|response to virus|type I interferon-mediated signaling pathway	cytosol|extracellular space	protein binding				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.05e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.54e-23)|Colorectal(212;5.37e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00238)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		ACGACCTGTTCTGGCTGACCT	0.662													3	48					0	0	0.115264	0	0
Unknown	0	broad.mit.edu	37	1	21753543	21753543	+	RNA	SNP	C	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:21753543C>A	uc001bep.1	-	2		c.48G>T								Homo sapiens cDNA FLJ25572 fis, clone JTH05111.																		TGGTCTTCTTCCTCTTCTTGG	0.463													6	21					0.000274275	0.0002862	0.047766	1	0
NBPF3	84224	broad.mit.edu	37	1	21807446	21807446	+	Nonsense_Mutation	SNP	G	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:21807446G>T	uc001ber.2	+	12	1755	c.1405G>T	c.(1405-1407)GAA>TAA	p.E469*	NBPF3_uc001bes.2_Nonsense_Mutation_p.E413*|NBPF3_uc009vqb.2_Nonsense_Mutation_p.E457*|NBPF3_uc010odm.1_Nonsense_Mutation_p.E399*	NM_032264	NP_115640	Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	469	Poly-Glu.|NBPF 4.					cytoplasm				upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CCAAGAAGAGGAAGAAGACCA	0.468													23	138					5.91797e-21	6.58423e-21	0.050027	1	0
TAF12	6883	broad.mit.edu	37	1	28930062	28930062	+	Missense_Mutation	SNP	T	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:28930062T>C	uc001bqw.2	-	5	568	c.475A>G	c.(475-477)ACC>GCC	p.T159A	TAF12_uc001bqx.2_Missense_Mutation_p.T159A|TAF12_uc001bqy.2_Missense_Mutation_p.T159A	NM_005644	NP_005635	Q16514	TAF12_HUMAN	TAF12 RNA polymerase II, TATA box binding	159					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Renal(390;0.00121)|Breast(348;0.00502)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)		Colorectal(126;3.21e-08)|COAD - Colon adenocarcinoma(152;1.74e-06)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(1967;0.0109)|BRCA - Breast invasive adenocarcinoma(304;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		TATTTCTTGGTTGTTTTCCGG	0.423													7	122					0	0	0.038147	0	0
CDC20	991	broad.mit.edu	37	1	43827899	43827899	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:43827899G>C	uc001cix.2	+	10	1338	c.1237G>C	c.(1237-1239)GAG>CAG	p.E413Q	CDC20_uc001ciy.2_Missense_Mutation_p.E413Q	NM_001255	NP_001246	Q12834	CDC20_HUMAN	cell division cycle 20	413	WD 6.				activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytosol|nucleoplasm|spindle	enzyme binding|protein C-terminus binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCATTACAAGGAGCTCATCTC	0.368													18	42					0	0	0.055883	0	0
CDC20	991	broad.mit.edu	37	1	43827910	43827910	+	Silent	SNP	A	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:43827910A>C	uc001cix.2	+	10	1349	c.1248A>C	c.(1246-1248)TCA>TCC	p.S416S	CDC20_uc001ciy.2_Silent_p.S416S	NM_001255	NP_001246	Q12834	CDC20_HUMAN	cell division cycle 20	416	WD 6.				activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytosol|nucleoplasm|spindle	enzyme binding|protein C-terminus binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGCTCATCTCAGGCCATGGCT	0.338													17	44					0	0	0.062417	0	0
LRRC41	10489	broad.mit.edu	37	1	46746151	46746151	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:46746151G>A	uc001cpn.2	-	6	1882	c.1838C>T	c.(1837-1839)TCG>TTG	p.S613L	LRRC41_uc010omb.1_Missense_Mutation_p.S613L	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	613	LRR 4.									ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					CAGAGAACCCGAGGCCTTCAG	0.567													57	90					0	0	0.139131	0	0
HOOK1	51361	broad.mit.edu	37	1	60312834	60312834	+	Silent	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:60312834G>A	uc009wad.2	+	11	1008	c.906G>A	c.(904-906)CTG>CTA	p.L302L	HOOK1_uc001czo.2_Silent_p.L302L|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Silent_p.L260L	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	302	Potential.|Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					CAAGAGCCCTGAAAGATGAAA	0.328													12	163					0	0	0.119110	0	0
CCDC18	343099	broad.mit.edu	37	1	93649015	93649015	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:93649015G>A	uc001dpq.2	+	2	619	c.451G>A	c.(451-453)GAA>AAA	p.E151K	TMED5_uc001dpn.2_5'Flank|TMED5_uc001dpo.2_5'Flank|TMED5_uc001dpp.2_5'Flank	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	33										ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		GAAGATAACAGAATGGAGTTT	0.338													43	56					0	0	0.139131	0	0
CCDC18	343099	broad.mit.edu	37	1	93711674	93711674	+	Missense_Mutation	SNP	G	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:93711674G>T	uc001dpq.2	+	22	3516	c.3348G>T	c.(3346-3348)ATG>ATT	p.M1116I	CCDC18_uc009wdl.1_Missense_Mutation_p.M633I	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	997	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		AATGCAAGATGGAGATTGAAG	0.353													11	136					6.40141e-05	6.76375e-05	0.080935	1	0
ATP8B2	57198	broad.mit.edu	37	1	154306711	154306711	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:154306711G>A	uc001fey.1	+	9	964	c.775G>A	c.(775-777)GAG>AAG	p.E259K	ATP8B2_uc001few.2_Missense_Mutation_p.E240K|ATP8B2_uc001fex.2_Missense_Mutation_p.E273K	NM_001005855	NP_001005855	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform b	259	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCGAAACACCGAGTGGTGCTT	0.532													15	415					0	0	0.132662	0	0
UFC1	51506	broad.mit.edu	37	1	161128205	161128205	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:161128205G>A	uc001fyd.3	+	6	681	c.427G>A	c.(427-429)GGT>AGT	p.G143S	USP21_uc010pkc.1_5'Flank|USP21_uc010pkd.1_5'Flank|USP21_uc010pke.1_5'Flank|USP21_uc010pkf.1_5'Flank	NM_016406	NP_057490	Q9Y3C8	UFC1_HUMAN	ubiquitin-fold modifier conjugating enzyme 1	143					protein ufmylation		protein binding|UFM1 conjugating enzyme activity				0	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			ATTGCAGCTGGGTCCATGGCT	0.478													52	84					0	0	0.139131	0	0
SLC9A11	284525	broad.mit.edu	37	1	173503755	173503755	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:173503755C>G	uc001giz.2	-	16	2265	c.1842G>C	c.(1840-1842)CAG>CAC	p.Q614H	SLC9A11_uc009wwe.2_Missense_Mutation_p.Q172H|SLC9A11_uc010pmq.1_Intron	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	614	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						AATTTATAATCTGTCCTGTAT	0.264													3	83					0	0	0.115264	0	0
FAM5C	339479	broad.mit.edu	37	1	190067662	190067662	+	Nonsense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:190067662C>T	uc001gse.1	-	8	2019	c.1787G>A	c.(1786-1788)TGG>TAG	p.W596*	FAM5C_uc010pot.1_Nonsense_Mutation_p.W494*	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	596						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					AGTCCGCTCCCAGTCTGGAAA	0.478													182	228					0	0	0.139131	0	0
LAMB3	3914	broad.mit.edu	37	1	209789963	209789963	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:209789963C>G	uc001hhg.2	-	21	3625	c.3235G>C	c.(3235-3237)GAG>CAG	p.E1079Q	LAMB3_uc009xco.2_Missense_Mutation_p.E1079Q|LAMB3_uc001hhh.2_Missense_Mutation_p.E1079Q	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	1079	Domain I.|Potential.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TTTATTCTCTCAAATCCCTGA	0.468													14	57					0	0	0.119110	0	0
LAMB3	3914	broad.mit.edu	37	1	209791342	209791342	+	Silent	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:209791342C>T	uc001hhg.2	-	19	3351	c.2961G>A	c.(2959-2961)CTG>CTA	p.L987L	LAMB3_uc009xco.2_Silent_p.L987L|LAMB3_uc001hhh.2_Silent_p.L987L	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	987	Domain I.|Potential.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TCCCCTGCCGCAGGTTCCCAA	0.602													15	56					0	0	0.043863	0	0
ACBD3	64746	broad.mit.edu	37	1	226346904	226346904	+	Missense_Mutation	SNP	A	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:226346904A>G	uc001hpy.2	-	5	931	c.884T>C	c.(883-885)GTC>GCC	p.V295A		NM_022735	NP_073572	Q9H3P7	GCP60_HUMAN	acyl-Coenzyme A binding domain containing 3	295	Gln-rich.				steroid biosynthetic process|transport	Golgi membrane|integral to membrane|mitochondrion	fatty-acyl-CoA binding|protein binding				0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.121)		TGCAAGCTGGACTTGATACAA	0.458													5	354					0	0	0.047766	0	0
LIN9	286826	broad.mit.edu	37	1	226426770	226426770	+	Nonsense_Mutation	SNP	C	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:226426770C>A	uc001hqa.2	-	12	1505	c.1195G>T	c.(1195-1197)GAA>TAA	p.E399*	LIN9_uc001hqb.2_Nonsense_Mutation_p.E364*|LIN9_uc001hqc.2_Nonsense_Mutation_p.E331*|LIN9_uc009xel.1_Nonsense_Mutation_p.E364*	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	383	Potential.				cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		CGCTGAAATTCAATGCTGATG	0.353													23	177					3.01185e-09	3.24353e-09	0.091800	1	0
PRSS38	339501	broad.mit.edu	37	1	228003831	228003831	+	Silent	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:228003831C>T	uc001hrh.2	+	2	189	c.189C>T	c.(187-189)GGC>GGT	p.G63G		NM_183062	NP_898885	A1L453	PRS38_HUMAN	marapsin 2 precursor	63	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)|pancreas(1)	2						TCCTGGGCGGCGTCCCTGCGC	0.617													12	92					0	0	0.043863	0	0
GALNT2	2590	broad.mit.edu	37	1	230398692	230398692	+	Silent	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:230398692G>A	uc010pwa.1	+	13	1326	c.1254G>A	c.(1252-1254)AGG>AGA	p.R418R	GALNT2_uc010pvy.1_Silent_p.R380R|GALNT2_uc010pvz.1_RNA|GALNT2_uc001htu.2_Silent_p.R30R	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	418	Lumenal (Potential).				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				TGGAGCTTAGGAAGAAACTCA	0.393													45	169					0	0	0.139131	0	0
PCNXL2	80003	broad.mit.edu	37	1	233372617	233372617	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:233372617G>A	uc001hvl.2	-	9	2567	c.2332C>T	c.(2332-2334)CGC>TGC	p.R778C	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA|PCNXL2_uc001hvq.1_Missense_Mutation_p.R77C	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	778						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				TGGGTCCTGCGAGCCACCATC	0.527													52	211					0	0	0.139131	0	0
RYR2	6262	broad.mit.edu	37	1	237789071	237789071	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:237789071G>C	uc001hyl.1	+	40	6253	c.6133G>C	c.(6133-6135)GAA>CAA	p.E2045Q		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2045	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAAGCAAGCAGAAAAACCAGT	0.443													21	71					0	0	0.049695	0	0
SFMBT2	57713	broad.mit.edu	37	10	7423844	7423844	+	Nonsense_Mutation	SNP	G	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr10:7423844G>C	uc009xio.1	-	2	108	c.17C>G	c.(16-18)TCA>TGA	p.S6*	SFMBT2_uc001ijn.1_Nonsense_Mutation_p.S6*|SFMBT2_uc010qay.1_Nonsense_Mutation_p.S6*|SFMBT2_uc001ijo.1_Nonsense_Mutation_p.S6*	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	6					regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						ATTGGAAGCTGACAAAGTGCT	0.403													7	47					0	0	0.029380	0	0
SEC61A2	55176	broad.mit.edu	37	10	12203080	12203080	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr10:12203080C>G	uc001ile.2	+	10	1274	c.1127C>G	c.(1126-1128)TCT>TGT	p.S376C	SEC61A2_uc010qbq.1_Missense_Mutation_p.S354C|SEC61A2_uc001ilf.3_RNA|SEC61A2_uc001ilh.3_RNA|SEC61A2_uc001ilg.3_Missense_Mutation_p.S376C	NM_018144	NP_060614	Q9H9S3	S61A2_HUMAN	Sec61 alpha form 2 isoform a	376	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1		Renal(717;0.228)				GCATTCTTCTCTAAGACATGG	0.363													40	68					0	0	0.111260	0	0
UCMA	221044	broad.mit.edu	37	10	13275614	13275614	+	Silent	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr10:13275614G>A	uc001imd.2	-	3	217	c.144C>T	c.(142-144)TTC>TTT	p.F48F		NM_145314	NP_660357	Q8WVF2	UCMA_HUMAN	upper zone of growth plate and cartilage matrix	48						proteinaceous extracellular matrix					0						ATTCCTGCATGAAAATCTTCT	0.592													22	72					0	0	0.069288	0	0
PDCD11	22984	broad.mit.edu	37	10	105197798	105197798	+	Missense_Mutation	SNP	A	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr10:105197798A>G	uc001kwy.1	+	26	3959	c.3872A>G	c.(3871-3873)AAC>AGC	p.N1291S		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1291	S1 motif 11.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		ACTGCAGACAACGTATTGACT	0.468													15	202					0	0	0.146539	0	0
PRLHR	2834	broad.mit.edu	37	10	120353959	120353959	+	Silent	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr10:120353959G>A	uc001ldp.1	-	2	937	c.798C>T	c.(796-798)GCC>GCT	p.A266A		NM_004248	NP_004239	P49683	PRLHR_HUMAN	G protein-coupled receptor 10	266	Cytoplasmic (Potential).				female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity				0		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		GGTCCCAGTCGGCCTGGCTCT	0.672													5	6					0	0	0.014758	0	0
OR51I1	390063	broad.mit.edu	37	11	5461827	5461827	+	Silent	SNP	G	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr11:5461827G>C	uc010qze.1	-	1	918	c.918C>G	c.(916-918)CTC>CTG	p.L306L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005288	NP_001005288	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGAAGAACTTGAGAATCCCTT	0.453													5	112					0	0	0.014758	0	0
OR52L1	338751	broad.mit.edu	37	11	6007548	6007548	+	Missense_Mutation	SNP	G	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr11:6007548G>T	uc001mcd.2	-	1	668	c.613C>A	c.(613-615)CTT>ATT	p.L205I		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	205	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGCAGGCAAGTTTCACAACA	0.478													6	91					5.68852e-11	6.16563e-11	0.047766	1	0
PRR5L	79899	broad.mit.edu	37	11	36484190	36484190	+	Silent	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr11:36484190C>T	uc001mwo.3	+	9	1400	c.1011C>T	c.(1009-1011)TCC>TCT	p.S337S	PRR5L_uc001mwp.2_Silent_p.S337S|PRR5L_uc009ykk.2_Silent_p.S209S|PRR5L_uc010rfc.1_3'UTR	NM_001160167	NP_001153639	Q6MZQ0	PRR5L_HUMAN	protor-2 isoform a	337										ovary(1)	1						GGCAGTGCTCCAGTGAGCCCA	0.667													13	19					0	0	0.119110	0	0
GPR137	56834	broad.mit.edu	37	11	64055225	64055225	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr11:64055225C>T	uc001nzg.1	+	4	748	c.440C>T	c.(439-441)TCG>TTG	p.S147L	GPR137_uc009ypj.1_Missense_Mutation_p.S153L|GPR137_uc010rni.1_Missense_Mutation_p.S205L|GPR137_uc001nze.1_Missense_Mutation_p.S147L|GPR137_uc001nzf.2_Missense_Mutation_p.S147L|GPR137_uc001nzh.1_Missense_Mutation_p.S147L|GPR137_uc001nzi.2_Missense_Mutation_p.S147L|GPR137_uc010rnj.1_Missense_Mutation_p.S147L	NM_020155	NP_064540	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	147	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1						GTGGGGGCCTCGCTGCTCTTT	0.682													6	37					0	0	0.029380	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103049938	103049938	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr11:103049938C>G	uc001pho.2	+	39	6467	c.6323C>G	c.(6322-6324)TCT>TGT	p.S2108C	DYNC2H1_uc001phn.1_Missense_Mutation_p.S2108C|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2108	AAA 2 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GCCACAATATCTAGAATGGGA	0.333													25	13					0	0	0.054565	0	0
A2M	2	broad.mit.edu	37	12	9265042	9265042	+	Missense_Mutation	SNP	T	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr12:9265042T>C	uc001qvk.1	-	3	474	c.361A>G	c.(361-363)ATG>GTG	p.M121V	A2M_uc009zgk.1_Intron	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	121					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TTCTTAACCATCACTGTGGTC	0.453													48	20					0	0	0.139131	0	0
LRP6	4040	broad.mit.edu	37	12	12303967	12303967	+	Missense_Mutation	SNP	T	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr12:12303967T>G	uc001rah.3	-	13	2939	c.2797A>C	c.(2797-2799)ACG>CCG	p.T933P	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.T933P	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	933	Extracellular (Potential).|Beta-propeller 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				AGGAAAGTCGTAGGAGCTTAA	0.353													17	72					0	0	0.146539	0	0
CCDC91	55297	broad.mit.edu	37	12	28605543	28605543	+	Nonsense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr12:28605543C>T	uc001riq.2	+	10	1073	c.1057C>T	c.(1057-1059)CAG>TAG	p.Q353*	CCDC91_uc001rio.2_Nonsense_Mutation_p.Q323*|CCDC91_uc009zjk.2_RNA|CCDC91_uc001rip.1_Nonsense_Mutation_p.Q353*|CCDC91_uc001rir.2_Nonsense_Mutation_p.Q191*|CCDC91_uc009zjl.2_Nonsense_Mutation_p.Q155*	NM_018318	NP_060788	Q7Z6B0	CCD91_HUMAN	GGA binding partner	353	Potential.|Homodimerization.				protein transport	Golgi apparatus|membrane				central_nervous_system(1)	1	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					AAAAGTATCTCAGGAAATTCA	0.279													25	121					0	0	0.099896	0	0
DENND5B	160518	broad.mit.edu	37	12	31648823	31648823	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr12:31648823C>T	uc001rki.1	-	2	344	c.158G>A	c.(157-159)AGA>AAA	p.R53K	DENND5B_uc001rkh.1_Missense_Mutation_p.R88K|DENND5B_uc001rkj.2_Missense_Mutation_p.R75K|DENND5B_uc001rkk.1_5'UTR	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	53	UDENN.					integral to membrane				ovary(1)|central_nervous_system(1)	2						TTTGAATGTTCTTCTCAAAGG	0.343													4	60					0	0	0.014758	0	0
PLEKHA9	51054	broad.mit.edu	37	12	45568077	45568077	+	Silent	SNP	A	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr12:45568077A>T	uc001rom.1	-	3	609	c.72T>A	c.(70-72)ACT>ACA	p.T24T	PLEKHA9_uc009zke.2_Silent_p.T24T	NM_015899	NP_056983			pleckstrin homology domain containing, family A												0	Lung SC(27;0.192)|Renal(347;0.236)			GBM - Glioblastoma multiforme(48;0.173)		TGGACACACCAGTTGTGGTCA	0.398													95	275					0	0	0.139131	0	0
HDAC7	51564	broad.mit.edu	37	12	48189022	48189022	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr12:48189022G>A	uc010slo.1	-	11	1424	c.1229C>T	c.(1228-1230)CCG>CTG	p.P410L	HDAC7_uc001rqe.2_5'Flank|HDAC7_uc001rqj.3_Missense_Mutation_p.P373L|HDAC7_uc001rqk.3_Missense_Mutation_p.P393L	NM_015401	NP_056216	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7 isoform a	371	Poly-Pro.|Transcription repression 2 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.137)		CATGGGGCCCGGCGGTGGGGG	0.637													102	57					0	0	0.139131	0	0
DNAJC14	85406	broad.mit.edu	37	12	56222390	56222390	+	Missense_Mutation	SNP	C	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr12:56222390C>A	uc001shx.1	-	2	257	c.53G>T	c.(52-54)GGT>GTT	p.G18V	DNAJC14_uc001shu.1_Missense_Mutation_p.G18V|DNAJC14_uc009zob.1_Missense_Mutation_p.G18V|DNAJC14_uc001shy.1_Missense_Mutation_p.G18V	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	18					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						GGAGGCACCACCACTGTGGTG	0.587													28	69					1.75199e-13	1.91126e-13	0.125774	1	0
ANKRD52	283373	broad.mit.edu	37	12	56638887	56638887	+	Missense_Mutation	SNP	A	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr12:56638887A>G	uc001skm.3	-	22	2582	c.2492T>C	c.(2491-2493)GTG>GCG	p.V831A		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	831	ANK 24.						protein binding			ovary(2)	2						AGGGACTTACACTGCACAGTG	0.532													40	124					0	0	0.104719	0	0
MED13L	23389	broad.mit.edu	37	12	116675500	116675500	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr12:116675500G>A	uc001tvw.2	-	2	138	c.83C>T	c.(82-84)ACG>ATG	p.T28M		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	28					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TTTGATTCCCGTGAGTTCAGC	0.403													48	67					0	0	0.139131	0	0
USPL1	10208	broad.mit.edu	37	13	31205523	31205523	+	Silent	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr13:31205523G>A	uc001utc.2	+	4	1212	c.780G>A	c.(778-780)TCG>TCA	p.S260S	USPL1_uc001utb.2_Silent_p.S79S|USPL1_uc001utd.2_Intron|USPL1_uc001ute.1_5'Flank	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	260					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		GACTGTGCTCGAAGGAGGAAT	0.408													45	89					0	0	0.131918	0	0
UTP14C	9724	broad.mit.edu	37	13	52605014	52605014	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr13:52605014C>T	uc001vgb.2	+	2	2609	c.2074C>T	c.(2074-2076)CGG>TGG	p.R692W	UTP14C_uc001vgc.2_RNA	NM_021645	NP_067677	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	692					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				ovary(3)|large_intestine(1)|breast(1)	5		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		TACCCACCATCGGCAATTTGA	0.478													8	187					0	0	0.047766	0	0
RASA3	22821	broad.mit.edu	37	13	114762093	114762093	+	Silent	SNP	G	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr13:114762093G>C	uc001vui.2	-	21	2186	c.2055C>G	c.(2053-2055)GTC>GTG	p.V685V	RASA3_uc010tkk.1_Silent_p.V653V|RASA3_uc001vuj.2_Silent_p.V302V	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	685	Btk-type.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			ACGGGTGGTAGACGGTGAGGC	0.637													8	12					0	0	0.038147	0	0
RNASE6	6039	broad.mit.edu	37	14	21250155	21250155	+	Silent	SNP	C	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr14:21250155C>A	uc001vye.3	+	2	590	c.297C>A	c.(295-297)GTC>GTA	p.V99V		NM_005615	NP_005606	Q93091	RNAS6_HUMAN	ribonuclease, RNase A family, k6 precursor	99					defense response|RNA catabolic process	extracellular region	nucleic acid binding|pancreatic ribonuclease activity				0	all_cancers(95;0.00406)		Epithelial(56;9.21e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0126)		CAAAGCCTGTCAACATGACTG	0.502													51	64					2.52991e-16	2.79621e-16	0.139131	1	0
Unknown	0	broad.mit.edu	37	14	22111569	22111569	+	Missense_Mutation	SNP	C	T	T	rs1063358		TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr14:22111569C>T	uc001wbk.3	+	2	173	c.140C>T	c.(139-141)ACG>ATG	p.T47M						SubName: Full=Putative uncharacterized protein ENSP00000374930;																		ATGACAGCTACGGAAGGTGCC	0.507													32	52					0	0	0.045705	0	0
MDGA2	161357	broad.mit.edu	37	14	47314992	47314992	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr14:47314992G>A	uc001wwj.3	-	16	2955	c.2759C>T	c.(2758-2760)GCA>GTA	p.A920V	MDGA2_uc001wwh.3_Missense_Mutation_p.A122V|MDGA2_uc001wwi.3_Missense_Mutation_p.A691V	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	920	MAM.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						GTCTTGTTTTGCACATTCTCC	0.308													23	30					0	0	0.083992	0	0
MDGA2	161357	broad.mit.edu	37	14	47351300	47351300	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr14:47351300G>A	uc001wwj.3	-	11	2352	c.2156C>T	c.(2155-2157)CCT>CTT	p.P719L	MDGA2_uc001wwh.3_5'UTR|MDGA2_uc001wwi.3_Missense_Mutation_p.P490L|MDGA2_uc010ani.2_Missense_Mutation_p.P279L	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	719					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TTTGGTGAGAGGAGTCAGTCG	0.299													19	20					0	0	0.055883	0	0
SYNE2	23224	broad.mit.edu	37	14	64491095	64491095	+	Nonsense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr14:64491095C>T	uc001xgm.2	+	39	5988	c.5758C>T	c.(5758-5760)CAG>TAG	p.Q1920*	SYNE2_uc001xgl.2_Nonsense_Mutation_p.Q1920*	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1920	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GCTCGTGGGTCAGGAATTCGA	0.448													20	38					0	0	0.049695	0	0
SPTB	6710	broad.mit.edu	37	14	65259917	65259917	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr14:65259917G>C	uc001xht.2	-	13	2518	c.2464C>G	c.(2464-2466)CGG>GGG	p.R822G	SPTB_uc001xhr.2_Missense_Mutation_p.R822G|SPTB_uc001xhs.2_Missense_Mutation_p.R822G|SPTB_uc001xhu.2_Missense_Mutation_p.R822G	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	822	Spectrin 6.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GCCTGCAGCCGATGGGTCACA	0.657													3	49					0	0	0.115264	0	0
SNW1	22938	broad.mit.edu	37	14	78205216	78205216	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr14:78205216C>G	uc001xuf.2	-	5	465	c.438G>C	c.(436-438)AAG>AAC	p.K146N	SNW1_uc010tvm.1_Missense_Mutation_p.K71N|SNW1_uc010asu.2_5'UTR|SNW1_uc010tvn.1_Missense_Mutation_p.K146N	NM_012245	NP_036377	Q13573	SNW1_HUMAN	SKI-interacting protein	146					negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|regulation of transcription from RNA polymerase II promoter	catalytic step 2 spliceosome|nucleoplasm	Notch binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		CTACTCTTGTCTTTTCTGTTA	0.398													5	173					0	0	0.014758	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103406262	103406262	+	Silent	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr14:103406262G>A	uc001ymi.1	-	33	4846	c.4614C>T	c.(4612-4614)GAC>GAT	p.D1538D		NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	1538					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TGTCGGAGGTGTCCGGCACGT	0.627													24	57					0	0	0.083992	0	0
RHOV	171177	broad.mit.edu	37	15	41165905	41165905	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr15:41165905C>G	uc001znd.2	-	2	394	c.244G>C	c.(244-246)GAG>CAG	p.E82Q		NM_133639	NP_598378	Q96L33	RHOV_HUMAN	ras homolog gene family, member V	82					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome membrane|plasma membrane	GTP binding|metal ion binding				0		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		TCCCAGAGCTCAATGCGCACC	0.662													27	63					0	0	0.134883	0	0
VPS13C	54832	broad.mit.edu	37	15	62283886	62283886	+	Nonsense_Mutation	SNP	G	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr15:62283886G>T	uc002agz.2	-	17	1543	c.1469C>A	c.(1468-1470)TCA>TAA	p.S490*	VPS13C_uc002aha.2_Nonsense_Mutation_p.S447*|VPS13C_uc002ahb.1_Nonsense_Mutation_p.S490*|VPS13C_uc002ahc.1_Nonsense_Mutation_p.S447*	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	490					protein localization					ovary(2)	2						AGGAATCAATGATTCTTCGTC	0.343													77	130					9.13743e-30	1.03026e-29	0.139131	1	0
AKAP13	11214	broad.mit.edu	37	15	86228062	86228062	+	Silent	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr15:86228062C>T	uc002blv.1	+	16	5417	c.5247C>T	c.(5245-5247)TTC>TTT	p.F1749F	AKAP13_uc002blt.1_Silent_p.F1731F|AKAP13_uc002blu.1_Silent_p.F1753F|AKAP13_uc010bnf.1_Silent_p.F371F|AKAP13_uc002blw.1_Silent_p.F216F|AKAP13_uc002blx.1_5'UTR|AKAP13_uc010bne.1_Silent_p.F402F	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	1749					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GTCGTACATTCAGCTACATCA	0.408													56	89					0	0	0.139131	0	0
FAM65A	79567	broad.mit.edu	37	16	67574374	67574374	+	Silent	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr16:67574374C>T	uc010vjp.1	+	9	801	c.705C>T	c.(703-705)TTC>TTT	p.F235F	FAM65A_uc010cei.1_Silent_p.F57F|FAM65A_uc002eth.2_Silent_p.F215F|FAM65A_uc010cej.2_Silent_p.F218F|FAM65A_uc002eti.1_Silent_p.F178F|FAM65A_uc010vjq.1_Silent_p.F229F|FAM65A_uc002etj.1_Silent_p.F214F|FAM65A_uc002etk.2_Silent_p.F214F	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	219						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		TGGCTGGCTTCGCCAGGCTGT	0.592													15	24					0	0	0.043863	0	0
PLCG2	5336	broad.mit.edu	37	16	81927367	81927367	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr16:81927367G>A	uc002fgt.2	+	12	1192	c.1040G>A	c.(1039-1041)CGC>CAC	p.R347H	PLCG2_uc010chg.1_Missense_Mutation_p.R347H	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	347	PI-PLC X-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						GCTTACATCCGCTGCCTGCGC	0.587													18	40					0	0	0.062417	0	0
ZNF594	84622	broad.mit.edu	37	17	5087112	5087112	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr17:5087112C>G	uc010cla.1	-	2	596	c.440G>C	c.(439-441)AGA>ACA	p.R147T		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	147	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TGTATGAATTCTCTGATGTAT	0.308													8	114					0	0	0.038147	0	0
MYH10	4628	broad.mit.edu	37	17	8404231	8404231	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr17:8404231C>G	uc002gll.2	-	27	3660	c.3564G>C	c.(3562-3564)AAG>AAC	p.K1188N	MYH10_uc002glm.2_Missense_Mutation_p.K1219N|MYH10_uc010cnx.2_Missense_Mutation_p.K1197N	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1188	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CTTCATGGTTCTTAGTTTCCT	0.483													11	175					0	0	0.069234	0	0
MYH8	4626	broad.mit.edu	37	17	10314183	10314183	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr17:10314183C>G	uc002gmm.2	-	15	1593	c.1498G>C	c.(1498-1500)GAG>CAG	p.E500Q	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	500	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TCCTCCTGCTCTAGCACAAAC	0.468									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				13	171					0	0	0.093190	0	0
CCL4	6351	broad.mit.edu	37	17	34431241	34431241	+	Translation_Start_Site	SNP	C	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr17:34431241C>A	uc002hkw.1	+	1	22	c.-57C>A	c.(-59--55)TTCTG>TTATG		CCL4_uc002hkx.1_RNA	NM_002984	NP_002975	P13236	CCL4_HUMAN	chemokine C-C motif ligand 4 isoform 1						cell adhesion|cell-cell signaling|cellular component movement|chemotaxis|establishment or maintenance of cell polarity|immune response|inflammatory response|response to virus|viral genome replication	extracellular space	chemokine activity|receptor signaling protein tyrosine kinase activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CAGCTGGGTTCTGAAGCTTCT	0.507													7	201					1.06961e-07	1.14455e-07	0.038147	1	0
HSF5	124535	broad.mit.edu	37	17	56540518	56540518	+	Silent	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr17:56540518C>T	uc002iwi.1	-	4	1291	c.1167G>A	c.(1165-1167)GAG>GAA	p.E389E		NM_001080439	NP_001073908	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	389						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCTTTACCATCTCCAATTTAG	0.428													38	69					0	0	0.080422	0	0
MFSD11	79157	broad.mit.edu	37	17	74771185	74771185	+	Silent	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr17:74771185C>T	uc002jta.2	+	12	1954	c.981C>T	c.(979-981)CTC>CTT	p.L327L	MFSD11_uc002jtb.2_Silent_p.L327L|MFSD11_uc010dha.2_Silent_p.L275L|MFSD11_uc002jtc.2_Silent_p.L327L|MFSD11_uc002jtd.3_Silent_p.L327L|MFSD11_uc010dhb.2_Silent_p.L275L|MFSD11_uc002jte.2_Silent_p.L327L	NM_024311	NP_077287	O43934	MFS11_HUMAN	major facilitator superfamily domain containing	327	Helical; (Potential).					integral to membrane				ovary(1)	1						TAATATTTCTCAACATGCCTG	0.458													49	117					0	0	0.139131	0	0
HDHD2	84064	broad.mit.edu	37	18	44641514	44641514	+	Missense_Mutation	SNP	T	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr18:44641514T>C	uc002lcs.2	-	5	734	c.601A>G	c.(601-603)ATG>GTG	p.M201V	HDHD2_uc002lct.2_Missense_Mutation_p.M111V	NM_032124	NP_115500	Q9H0R4	HDHD2_HUMAN	haloacid dehalogenase-like hydrolase domain	201							hydrolase activity				0						TCTCCTATCATGACAGCCTCC	0.512													3	96					0	0	0.115264	0	0
TBXA2R	6915	broad.mit.edu	37	19	3595827	3595827	+	Silent	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr19:3595827G>A	uc002lyg.1	-	3	1105	c.891C>T	c.(889-891)GCC>GCT	p.A297A	TBXA2R_uc002lye.1_Missense_Mutation_p.H168Y	NM_001060	NP_001051	P21731	TA2R_HUMAN	thromboxane A2 receptor isoform alpha	297	Helical; Name=7; (Potential).				platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)	GGTTCCAGGTGGCCACGCGCA	0.677													4	0					0	0	0.014758	0	0
MUC16	94025	broad.mit.edu	37	19	9061666	9061666	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr19:9061666G>C	uc002mkp.2	-	3	25984	c.25780C>G	c.(25780-25782)CTC>GTC	p.L8594V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8596	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCAAGGGTGAGAAGTGCAGTC	0.488													23	111					0	0	0.076483	0	0
TYK2	7297	broad.mit.edu	37	19	10468442	10468442	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr19:10468442C>T	uc002moc.3	-	17	2842	c.2464G>A	c.(2464-2466)GAG>AAG	p.E822K	TYK2_uc010dxe.2_Missense_Mutation_p.E637K|TYK2_uc002mod.2_Missense_Mutation_p.E822K	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	822	Protein kinase 1.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			AGACATACCTCGGAGGGACTG	0.617													4	17					0	0	0.014758	0	0
S1PR5	53637	broad.mit.edu	37	19	10625529	10625529	+	Silent	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr19:10625529C>T	uc002mot.1	-	2	216	c.159G>A	c.(157-159)GAG>GAA	p.E53E	S1PR5_uc002mou.1_Silent_p.E53E	NM_030760	NP_110387	Q9H228	S1PR5_HUMAN	endothelial differentiation, sphingolipid	53	Helical; Name=1; (By similarity).					integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|pancreas(1)	2						CGGCTAGATTCTCTAGCACGA	0.682													3	20					0	0	0.115264	0	0
ZNF491	126069	broad.mit.edu	37	19	11917006	11917006	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr19:11917006C>T	uc002mso.1	+	3	523	c.238C>T	c.(238-240)CGT>TGT	p.R80C		NM_152356	NP_689569	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	80					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						ACATAAACAACGTAGGAAAGC	0.383													116	34					0	0	0.139131	0	0
ZNF440	126070	broad.mit.edu	37	19	11943292	11943292	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr19:11943292G>C	uc002msp.1	+	4	1457	c.1301G>C	c.(1300-1302)AGA>ACA	p.R434T		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	434	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAGCCTTCAGATATGTGAAT	0.418													11	137					0	0	0.093190	0	0
ZNF440	126070	broad.mit.edu	37	19	11943610	11943610	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr19:11943610G>C	uc002msp.1	+	4	1775	c.1619G>C	c.(1618-1620)AGA>ACA	p.R540T		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	540					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACCCTGAAGAGAAACCCTATG	0.488													10	123					0	0	0.093190	0	0
ZNF763	284390	broad.mit.edu	37	19	12076010	12076010	+	Translation_Start_Site	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr19:12076010C>G	uc002msw.2	+	1	142	c.-13C>G	c.(-15--11)ATCTG>ATGTG		ZNF763_uc010xmf.1_Intron|ZNF763_uc002msv.2_Translation_Start_Site|ZNF763_uc010xmg.1_Translation_Start_Site	NM_001012753	NP_001012771	Q0D2J5	ZN763_HUMAN	zinc finger protein 763						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						CCCAGGACATCTGAAAGCCAG	0.632													7	37					0	0	0.038147	0	0
CPAMD8	27151	broad.mit.edu	37	19	17056395	17056395	+	Silent	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr19:17056395G>A	uc002nfb.2	-	22	2930	c.2898C>T	c.(2896-2898)ATC>ATT	p.I966I		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	919						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GATCCACCCCGATGGGGACCC	0.592													5	139					0	0	0.021553	0	0
ALDH16A1	126133	broad.mit.edu	37	19	49971789	49971789	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr19:49971789C>T	uc002pnt.2	+	15	2206	c.2090C>T	c.(2089-2091)GCG>GTG	p.A697V	ALDH16A1_uc010yar.1_Missense_Mutation_p.A646V|ALDH16A1_uc010yas.1_Missense_Mutation_p.A532V|ALDH16A1_uc010yat.1_Missense_Mutation_p.A534V	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	697							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		GTGCCCAGTGCGGCCTGTCCT	0.667													5	153					0	0	0.021553	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56704223	56704223	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr19:56704223C>T	uc010ygh.1	-	1	199	c.199G>A	c.(199-201)GAG>AAG	p.E67K		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	67	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TGGCACAGCTCAGTGAGTTTC	0.557													19	35					0	0	0.076483	0	0
ZSCAN5A	79149	broad.mit.edu	37	19	56733683	56733683	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr19:56733683C>G	uc002qmq.2	-	5	918	c.752G>C	c.(751-753)AGA>ACA	p.R251T	ZSCAN5A_uc010ygi.1_Missense_Mutation_p.R134T|ZSCAN5A_uc002qmr.2_Missense_Mutation_p.R251T|ZSCAN5A_uc002qms.1_Missense_Mutation_p.R250T	NM_024303	NP_077279	Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	251					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CTCCTTTGCTCTCACCAGATC	0.483													50	122					0	0	0.139131	0	0
NBAS	51594	broad.mit.edu	37	2	15307388	15307388	+	Silent	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr2:15307388C>T	uc002rcc.1	-	52	6926	c.6900G>A	c.(6898-6900)CTG>CTA	p.L2300L	NBAS_uc002rcb.1_Silent_p.L140L|NBAS_uc010exl.1_Silent_p.L1372L|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	2300										ovary(2)|liver(1)|skin(1)	4						CACACTTCACCAGCAGCTTGG	0.537													12	27					0	0	0.093190	0	0
ETAA1	54465	broad.mit.edu	37	2	67631386	67631386	+	Silent	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr2:67631386G>A	uc002sdz.1	+	5	1711	c.1572G>A	c.(1570-1572)TTG>TTA	p.L524L		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	524						cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						AGTCAGCTTTGAACACAAGGT	0.318													4	89					0	0	0.009096	0	0
HK2	3099	broad.mit.edu	37	2	75116397	75116397	+	Nonsense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr2:75116397C>T	uc002snd.2	+	17	4327	c.2401C>T	c.(2401-2403)CGA>TGA	p.R801*		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	801	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						GCTGCAAGTCCGAGCCATCCT	0.607													14	27					0	0	0.119110	0	0
RPIA	22934	broad.mit.edu	37	2	88991297	88991297	+	Silent	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr2:88991297C>T	uc002ste.2	+	1	122	c.81C>T	c.(79-81)TCC>TCT	p.S27S		NM_144563	NP_653164	P49247	RPIA_HUMAN	ribose 5-phosphate isomerase A	27					pentose-phosphate shunt, non-oxidative branch	cytosol	ribose-5-phosphate isomerase activity			ovary(1)	1		Acute lymphoblastic leukemia(2;0.000456)|all_hematologic(2;0.00287)				gcgcggcctccggcggAGGAG	0.567													4	9					0	0	0.014758	0	0
DFNB59	494513	broad.mit.edu	37	2	179325902	179325902	+	Silent	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr2:179325902G>A	uc002umi.3	+	7	1316	c.960G>A	c.(958-960)GAG>GAA	p.E320E	DFNB59_uc002umj.3_Silent_p.E320E	NM_001042702	NP_001036167	Q0ZLH3	PJVK_HUMAN	deafness, autosomal recessive 59	320					sensory perception of sound						0			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			TCAAAAGGGAGACAGTTTATG	0.408													7	223					0	0	0.038147	0	0
TTN	7273	broad.mit.edu	37	2	179412236	179412236	+	Missense_Mutation	SNP	G	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr2:179412236G>T	uc010zfg.1	-	288	86637	c.86413C>A	c.(86413-86415)CTC>ATC	p.L28805I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L22500I|TTN_uc010zfi.1_Missense_Mutation_p.L22433I|TTN_uc010zfj.1_Missense_Mutation_p.L22308I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29732							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTTTGTGAGATGAGTGACT	0.388													7	19					8.12818e-05	8.53459e-05	0.029380	1	0
TTN	7273	broad.mit.edu	37	2	179458767	179458767	+	Silent	SNP	A	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr2:179458767A>G	uc010zfg.1	-	246	50873	c.50649T>C	c.(50647-50649)CGT>CGC	p.R16883R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.R10578R|TTN_uc010zfi.1_Silent_p.R10511R|TTN_uc010zfj.1_Silent_p.R10386R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17810							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGGAATCTGAACGTTTGGCCT	0.413													62	110					0	0	0.139131	0	0
AQP12A	375318	broad.mit.edu	37	2	241631397	241631397	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr2:241631397C>T	uc002vzu.2	+	1	136	c.67C>T	c.(67-69)CGG>TGG	p.R23W	AQP12A_uc002vzv.2_Intron	NM_198998	NP_945349	Q8IXF9	AQ12A_HUMAN	aquaporin 12A	23						integral to membrane	transporter activity				0		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		GGCGGCCAGGCGGGCCTCCAA	0.687													13	20					0	0	0.119110	0	0
DIDO1	11083	broad.mit.edu	37	20	61527728	61527728	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr20:61527728C>G	uc002ydr.1	-	8	2335	c.2071G>C	c.(2071-2073)GAC>CAC	p.D691H	DIDO1_uc002yds.1_Missense_Mutation_p.D691H|DIDO1_uc002ydt.1_Missense_Mutation_p.D691H|DIDO1_uc002ydu.1_Missense_Mutation_p.D691H	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	691	TFIIS central.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					ATGATTAAGTCATCGCTGTCA	0.358													29	48					0	0	0.108266	0	0
GRIK1	2897	broad.mit.edu	37	21	30909691	30909691	+	Missense_Mutation	SNP	C	T	T	rs151335244	by1000genomes	TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr21:30909691C>T	uc011acs.1	-	17	3087	c.2623G>A	c.(2623-2625)GCT>ACT	p.A875T	GRIK1_uc002ynn.2_Missense_Mutation_p.A860T|GRIK1_uc011act.1_Missense_Mutation_p.A736T	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	Error:Variant_position_missing_in_P39086_after_alignment					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TCCATGATAGCGTTGAAAGAG	0.398													17	27					0	0	0.038395	0	0
IL10RB	3588	broad.mit.edu	37	21	34648988	34648988	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr21:34648988G>C	uc002yrk.1	+	3	360	c.261G>C	c.(259-261)TTG>TTC	p.L87F	IL10RB_uc002yrh.1_Missense_Mutation_p.L157F|IL10RB_uc002yri.1_Missense_Mutation_p.L40F|IL10RB_uc002yrl.1_Missense_Mutation_p.L89F	NM_000628	NP_000619	Q08334	I10R2_HUMAN	interleukin 10 receptor, beta precursor	87	Extracellular (Potential).				immune response|inflammatory response	interleukin-28 receptor complex	protein binding|receptor activity				0						ACCACACCTTGAGAGTCAGGG	0.393													10	206					0	0	0.058154	0	0
DGCR2	9993	broad.mit.edu	37	22	19036055	19036055	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr22:19036055C>T	uc002zoq.1	-	7	1152	c.904G>A	c.(904-906)GAG>AAG	p.E302K	DGCR2_uc002zor.1_Missense_Mutation_p.E78K|DGCR2_uc011agr.1_Missense_Mutation_p.E258K|DGCR11_uc002zos.2_5'Flank	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	302	Extracellular (Potential).|VWFC.				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					ATCTCAGGCTCCCCTCCATGG	0.572													126	189					0	0	0.139131	0	0
NAGA	4668	broad.mit.edu	37	22	42461877	42461877	+	Silent	SNP	G	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr22:42461877G>T	uc003bbx.2	-	7	761	c.624C>A	c.(622-624)ATC>ATA	p.I208I	NAGA_uc003bby.2_Silent_p.I208I|NAGA_uc003bbw.3_Silent_p.I208I	NM_000262	NP_000253	P17050	NAGAB_HUMAN	alpha-N-acetylgalactosaminidase precursor	208					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)	1						AGAGGTTGCAGATGTCCGCCA	0.572													4	38					0.00909568	0.00937469	0.009096	1	0
LHFPL4	375323	broad.mit.edu	37	3	9594298	9594298	+	Silent	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr3:9594298G>A	uc003bry.2	-	2	352	c.66C>T	c.(64-66)ATC>ATT	p.I22I		NM_198560	NP_940962	Q7Z7J7	LHPL4_HUMAN	lipoma HMGIC fusion partner-like 4	22	Helical; (Potential).					integral to membrane				ovary(2)|skin(1)	3	Medulloblastoma(99;0.227)					ACAGCACGCCGATGGCCCGCG	0.542													10	16					0	0	0.093190	0	0
SCN5A	6331	broad.mit.edu	37	3	38592173	38592173	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr3:38592173C>T	uc003cio.2	-	28	5884	c.5690G>A	c.(5689-5691)CGG>CAG	p.R1897Q	SCN5A_uc003cin.2_Missense_Mutation_p.R1896Q|SCN5A_uc003cil.3_Missense_Mutation_p.R1897Q|SCN5A_uc010hhi.2_Missense_Mutation_p.R1879Q|SCN5A_uc010hhk.2_Missense_Mutation_p.R1864Q|SCN5A_uc011ayr.1_Missense_Mutation_p.R1843Q	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1897					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GTGCTTGCGCCGGAGTGTGGT	0.582													28	59					0	0	0.050027	0	0
CCR9	10803	broad.mit.edu	37	3	45942736	45942736	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr3:45942736G>A	uc003coz.1	+	3	613	c.456G>A	c.(454-456)ATG>ATA	p.M152I	LZTFL1_uc003coy.1_Intron|LZTFL1_uc011bak.1_Intron|CCR9_uc010hiv.1_Missense_Mutation_p.M140I|CCR9_uc003cpa.1_Missense_Mutation_p.M140I	NM_031200	NP_112477	P51686	CCR9_HUMAN	chemokine (C-C motif) receptor 9 isoform A	152	Cytoplasmic (Potential).				cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane				ovary(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00118)|KIRC - Kidney renal clear cell carcinoma(197;0.0182)|Kidney(197;0.0214)		CCCAGGCCATGAGAGCACATA	0.473													24	43					0	0	0.069288	0	0
SMARCC1	6599	broad.mit.edu	37	3	47703996	47703996	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr3:47703996C>G	uc003crq.2	-	20	2104	c.1986G>C	c.(1984-1986)TTG>TTC	p.L662F	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Missense_Mutation_p.L553F	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	662	SANT.				chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		TGGGAAGTCTCAAAAAGTGGA	0.473													27	41					0	0	0.091800	0	0
TRPC1	7220	broad.mit.edu	37	3	142443466	142443466	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr3:142443466C>T	uc003evc.2	+	1	201	c.65C>T	c.(64-66)TCT>TTT	p.S22F	TRPC1_uc003evb.2_Missense_Mutation_p.S22F	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	22	Cytoplasmic (Potential).				axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						ctgccttcctctccatcctct	0.517													4	30					0	0	0.009096	0	0
TRPC1	7220	broad.mit.edu	37	3	142443468	142443468	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr3:142443468C>T	uc003evc.2	+	1	203	c.67C>T	c.(67-69)CCA>TCA	p.P23S	TRPC1_uc003evb.2_Missense_Mutation_p.P23S	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	23	Cytoplasmic (Potential).				axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						gccttcctctccatcctcttc	0.512													4	30					0	0	0.009096	0	0
ZIC1	7545	broad.mit.edu	37	3	147128259	147128259	+	Silent	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr3:147128259C>G	uc003ewe.2	+	1	1079	c.360C>G	c.(358-360)CTC>CTG	p.L120L		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	120					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AGCACAGCCTCTTTGCTGCAT	0.706													5	24					0	0	0.047766	0	0
PEX5L	51555	broad.mit.edu	37	3	179593161	179593161	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr3:179593161C>T	uc003fki.1	-	6	740	c.610G>A	c.(610-612)GGA>AGA	p.G204R	PEX5L_uc011bqd.1_Missense_Mutation_p.G161R|PEX5L_uc011bqe.1_Missense_Mutation_p.G12R|PEX5L_uc011bqf.1_Missense_Mutation_p.G96R|PEX5L_uc003fkj.1_Missense_Mutation_p.G169R|PEX5L_uc010hxd.1_Missense_Mutation_p.G202R|PEX5L_uc011bqg.1_Missense_Mutation_p.G180R|PEX5L_uc011bqh.1_Missense_Mutation_p.G145R	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	204					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			TCTTTTGATCCAGTTCTAGAT	0.378													229	94					0	0	0.139131	0	0
LIPH	200879	broad.mit.edu	37	3	185252685	185252685	+	Silent	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr3:185252685C>T	uc003fpm.2	-	2	395	c.285G>A	c.(283-285)TTG>TTA	p.L95L	LIPH_uc010hyh.2_Silent_p.L95L	NM_139248	NP_640341	Q8WWY8	LIPH_HUMAN	lipase, member H precursor	95					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			ovary(1)|pancreas(1)	2	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			CAACAGAGAGCAAACCCTTTA	0.433													44	291					0	0	0.111260	0	0
TP63	8626	broad.mit.edu	37	3	189608648	189608648	+	Nonsense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr3:189608648C>T	uc003fry.2	+	13	1812	c.1723C>T	c.(1723-1725)CAG>TAG	p.Q575*	TP63_uc003frz.2_Intron|TP63_uc010hzc.1_Intron|TP63_uc003fsc.2_Nonsense_Mutation_p.Q481*|TP63_uc003fsd.2_Intron|TP63_uc010hzd.1_Nonsense_Mutation_p.Q396*	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	575	SAM.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CACCATCTATCAGATTGAGCA	0.443									Hay-Wells_syndrome	HNSCC(45;0.13)			37	140					0	0	0.092188	0	0
UBXN7	26043	broad.mit.edu	37	3	196089280	196089280	+	Silent	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr3:196089280G>A	uc003fwm.3	-	9	1188	c.1113C>T	c.(1111-1113)GTC>GTT	p.V371V	UBXN7_uc003fwn.3_Silent_p.V223V|UBXN7_uc010iae.2_Silent_p.V209V	NM_015562	NP_056377	O94888	UBXN7_HUMAN	UBX domain containing 7	371							protein binding			ovary(2)|pancreas(1)	3						GATCAGTTCTGACTGGTGGCT	0.493													20	316					0	0	0.062417	0	0
ENAM	10117	broad.mit.edu	37	4	71509395	71509395	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr4:71509395C>T	uc011caw.1	+	9	2533	c.2252C>T	c.(2251-2253)GCC>GTC	p.A751V		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	751					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			GTTAATAATGCCGCTGGACCA	0.458													3	58					0	0	0.115264	0	0
DCHS2	54798	broad.mit.edu	37	4	155161923	155161923	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr4:155161923C>G	uc003inw.2	-	23	5760	c.5760G>C	c.(5758-5760)TTG>TTC	p.L1920F		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1920	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AAGCTGAATTCAAATCCACAT	0.393													21	40					0	0	0.069288	0	0
GLRB	2743	broad.mit.edu	37	4	158057979	158057979	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr4:158057979C>T	uc003ipj.2	+	6	753	c.551C>T	c.(550-552)CCT>CTT	p.P184L		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	184	Extracellular (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	CTTTCATGCCCTTTGGACTTG	0.333													3	79					0	0	0.115264	0	0
FAT2	2196	broad.mit.edu	37	5	150925842	150925842	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr5:150925842G>C	uc003lue.3	-	9	4859	c.4846C>G	c.(4846-4848)CAA>GAA	p.Q1616E	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1616	Extracellular (Potential).|Cadherin 14.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCAAGCTTTTGAGCTAGAGTA	0.473													17	26					0	0	0.033300	0	0
C5orf54	63920	broad.mit.edu	37	5	159821108	159821108	+	Missense_Mutation	SNP	T	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr5:159821108T>C	uc003lye.1	-	2	1854	c.1390A>G	c.(1390-1392)ATT>GTT	p.I464V	C5orf54_uc003lyf.1_Missense_Mutation_p.I464V	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	464										pancreas(1)	1						agatctccaatggaaaaatat	0													53	84					0	0	0.139131	0	0
SLC17A4	10050	broad.mit.edu	37	6	25777127	25777127	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr6:25777127C>T	uc003nfe.2	+	10	1327	c.1208C>T	c.(1207-1209)TCT>TTT	p.S403F	SLC17A4_uc011djx.1_Missense_Mutation_p.S173F|SLC17A4_uc003nff.1_Missense_Mutation_p.S192F|SLC17A4_uc003nfg.2_Missense_Mutation_p.S340F|SLC17A4_uc010jqa.2_Intron	NM_005495	NP_005486	Q9Y2C5	S17A4_HUMAN	solute carrier family 17 (sodium phosphate),	403	Helical; (Potential).				phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			skin(1)	1						GTGCTGTCTTCTGCCATCAGC	0.532													6	115					0	0	0.021553	0	0
BTN2A2	10385	broad.mit.edu	37	6	26392863	26392863	+	Nonsense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr6:26392863C>T	uc003nhq.2	+	8	1326	c.1240C>T	c.(1240-1242)CAG>TAG	p.Q414*	BTN2A2_uc011dkg.1_3'UTR|BTN2A2_uc003nhr.2_Nonsense_Mutation_p.Q298*|BTN2A2_uc011dkh.1_Nonsense_Mutation_p.Q204*|BTN2A2_uc003nhs.2_Intron|BTN2A2_uc003nht.2_Nonsense_Mutation_p.Q414*|BTN2A2_uc011dki.1_3'UTR	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	414	B30.2/SPRY.|Cytoplasmic (Potential).				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						GCTGATTCCTCAGAATGGCTT	0.557													6	51					0	0	0.047766	0	0
OR10C1	442194	broad.mit.edu	37	6	29408150	29408150	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr6:29408150G>A	uc011dlp.1	+	1	358	c.358G>A	c.(358-360)GAC>AAC	p.D120N	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CATGGCCTATGACCGCTATGC	0.627													4	57					0	0	0.009096	0	0
COL12A1	1303	broad.mit.edu	37	6	75884903	75884903	+	Missense_Mutation	SNP	C	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr6:75884903C>A	uc003phs.2	-	13	2727	c.2561G>T	c.(2560-2562)GGT>GTT	p.G854V	COL12A1_uc003pht.2_Intron	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	854	Fibronectin type-III 5.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TTGAGTTTCACCCCCTGCCAC	0.483													48	133					4.96213e-28	5.55759e-28	0.139131	1	0
C6orf192	116843	broad.mit.edu	37	6	133100529	133100529	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr6:133100529C>T	uc003qdw.1	-	7	825	c.673G>A	c.(673-675)GAA>AAA	p.E225K	C6orf192_uc010kgd.1_RNA|C6orf192_uc011eco.1_Missense_Mutation_p.E99K	NM_052831	NP_439896	Q6NT16	CF192_HUMAN	hypothetical protein LOC116843	225	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;0.00303)|GBM - Glioblastoma multiforme(226;0.0265)		AATGAGTGTTCACCTGGATCA	0.368													29	65					0	0	0.050027	0	0
ECT2L	345930	broad.mit.edu	37	6	139203908	139203908	+	Missense_Mutation	SNP	C	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr6:139203908C>A	uc003qif.1	+	14	2031	c.1928C>A	c.(1927-1929)GCT>GAT	p.A643D	ECT2L_uc011edq.1_Missense_Mutation_p.A574D	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	643	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						TGGGGCCCAGCTCACTGTGTG	0.403													23	48					3.10358e-05	3.30001e-05	0.069288	1	0
LRP11	84918	broad.mit.edu	37	6	150158587	150158587	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr6:150158587G>A	uc003qng.2	-	4	1250	c.926C>T	c.(925-927)ACT>ATT	p.T309I	LRP11_uc003qnh.1_Missense_Mutation_p.T309I	NM_032832	NP_116221	Q86VZ4	LRP11_HUMAN	low density lipoprotein receptor-related protein	309	Extracellular (Potential).|LDL-receptor class A.					integral to membrane	receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;4.56e-12)|GBM - Glioblastoma multiforme(68;0.225)		GCGTGAGCAAGTGTGCAAACA	0.502													20	26					0	0	0.062417	0	0
PARK2	5071	broad.mit.edu	37	6	161969941	161969941	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr6:161969941G>A	uc003qtx.3	-	9	1162	c.1028C>T	c.(1027-1029)CCG>CTG	p.P343L	PARK2_uc003qtv.3_Intron|PARK2_uc010kkd.2_Missense_Mutation_p.P152L|PARK2_uc003qtw.3_Missense_Mutation_p.P152L|PARK2_uc003qty.3_Missense_Mutation_p.P315L|PARK2_uc003qtz.3_Missense_Mutation_p.P194L|PARK2_uc010kke.1_Missense_Mutation_p.P362L|PARK2_uc011egf.1_Missense_Mutation_p.P17L	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	343	IBR-type.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		GTCAGGCTCCGGCAGCAGCCC	0.637													34	45					0	0	0.092188	0	0
CDK13	8621	broad.mit.edu	37	7	40118338	40118338	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr7:40118338G>A	uc003thh.3	+	11	3199	c.2917G>A	c.(2917-2919)GAC>AAC	p.D973N	CDK13_uc003thi.3_Missense_Mutation_p.D973N|CDK13_uc003thj.2_Missense_Mutation_p.D24N	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	973	Protein kinase.				alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						AGCTGCGCTAGACTTATTTGA	0.408													39	27					0	0	0.131918	0	0
SBDS	51119	broad.mit.edu	37	7	66460333	66460333	+	Silent	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr7:66460333C>T	uc003tvm.1	-	1	256	c.72G>A	c.(70-72)GGG>GGA	p.G24G	TYW1_uc003tvn.2_5'Flank|TYW1_uc010lai.2_5'Flank	NM_016038	NP_057122	Q9Y3A5	SBDS_HUMAN	Shwachman-Bodian-Diamond syndrome protein	24					bone marrow development|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|mitotic spindle stabilization|positive regulation of translation|ribosomal large subunit biogenesis|rRNA processing	cytoplasm|nucleolus|nucleoplasm|spindle pole	microtubule binding|ribosome binding|rRNA binding			ovary(1)	1						CGAAGCGCTTCCCGGCACGCT	0.637			Gene Conversion			AML|MDS			Shwachman-Diamond_syndrome				14	37					0	0	0.132662	0	0
SPDYE5	442590	broad.mit.edu	37	7	75124543	75124543	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr7:75124543G>A	uc011kfy.1	+	1	245	c.109G>A	c.(109-111)GAA>AAA	p.E37K		NM_001099435	NP_001092905	A6NIY4	SPDE5_HUMAN	speedy homolog E5	37											0						GTGGTCAGATGAATCTGCGGA	0.587													4	47					0	0	0.029380	0	0
ASB4	51666	broad.mit.edu	37	7	95157220	95157220	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr7:95157220G>A	uc011kij.1	+	3	583	c.583G>A	c.(583-585)GTG>ATG	p.V195M	ASB4_uc003unx.2_Missense_Mutation_p.V195M	NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	195	ANK 4.				intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			GGCCTTCTACGTGGAACACGG	0.597											OREG0018172	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	40					0	0	0.038395	0	0
SPDYE3	441272	broad.mit.edu	37	7	99909547	99909547	+	5'Flank	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr7:99909547C>T	uc003uug.1	+							NM_001004351	NP_001004351	A6NKU9	SPDE3_HUMAN	speedy homolog E3												0						CGGCGAGTGTCGCTCGTGCTC	0.577													15	34					0	0	0.132662	0	0
TMEM68	137695	broad.mit.edu	37	8	56668938	56668938	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr8:56668938C>G	uc003xsg.1	-	2	427	c.358G>C	c.(358-360)GAA>CAA	p.E120Q	TMEM68_uc003xsh.1_Missense_Mutation_p.E120Q	NM_152417	NP_689630	Q96MH6	TMM68_HUMAN	transmembrane protein 68	120						integral to membrane	acyltransferase activity			skin(1)	1			Epithelial(17;0.000361)|all cancers(17;0.00326)			GGTCCATCTTCTGGTATTTTT	0.303													3	114					0	0	0.009096	0	0
BHLHE22	27319	broad.mit.edu	37	8	65494180	65494180	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr8:65494180G>A	uc003xvi.2	+	1	1367	c.833G>A	c.(832-834)CGA>CAA	p.R278Q	LOC401463_uc003xvh.2_Intron	NM_152414	NP_689627	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix domain containing, class	278	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						CCCTCGGTGCGAAAGCTCTCC	0.647													8	16					0	0	0.047766	0	0
OPLAH	26873	broad.mit.edu	37	8	145106962	145106962	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr8:145106962C>T	uc003zar.3	-	25	3561	c.3479G>A	c.(3478-3480)CGC>CAC	p.R1160H		NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	1160							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CTCGAAGCGGCGCAGGATGAC	0.751													4	6					0	0	0.021553	0	0
IFNA1	3439	broad.mit.edu	37	9	21440588	21440588	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr9:21440588G>A	uc003zpd.1	+	1	149	c.82G>A	c.(82-84)GAG>AAG	p.E28K		NM_024013	NP_076918	P01562	IFNA1_HUMAN	interferon, alpha 1 precursor	28					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(2)	2				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0173)		TGATCTCCCTGAGACCCACAG	0.517													5	72					0	0	0.014758	0	0
NOTCH1	4851	broad.mit.edu	37	9	139399461	139399461	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr9:139399461C>T	uc004chz.2	-	26	4682	c.4682G>A	c.(4681-4683)TGT>TAT	p.C1561Y	NOTCH1_uc004cia.1_Missense_Mutation_p.C791Y	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1561	Extracellular (Potential).|LNR 3.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ATGCTCCGCACAGTCCAGCCC	0.677			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			4	2					0	0	0.029380	0	0
Unknown	0	broad.mit.edu	37	MT	3554	3554	+	RNA	SNP	T	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chrM:3554T>C	uc004cos.3	+	2		c.1847T>C			uc011mfh.1_5'Flank					Homo sapiens mRNA expressed only in placental villi, clone SMAP47.																		CACCATCGCTCTTCTACTATG	0.532													3	0					0	0	0.115264	0	0
DMD	1756	broad.mit.edu	37	X	32509432	32509432	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chrX:32509432C>T	uc004dda.1	-	20	2828	c.2584G>A	c.(2584-2586)GAG>AAG	p.E862K	DMD_uc004dcz.2_Missense_Mutation_p.E739K|DMD_uc004dcy.1_Missense_Mutation_p.E858K|DMD_uc004ddb.1_Missense_Mutation_p.E854K|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	862	Spectrin 5.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GCTGTTGGCTCTGATGGGGTG	0.378													47	154					0	0	0.139131	0	0
ERCC6L	54821	broad.mit.edu	37	X	71427938	71427938	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chrX:71427938G>A	uc004eaq.1	-	2	776	c.679C>T	c.(679-681)CTC>TTC	p.L227F	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_Missense_Mutation_p.L104F	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	227	Helicase ATP-binding.				cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)					GCTTCATCGAGGATGACATAG	0.413													65	192					0	0	0.139131	0	0
CENPI	2491	broad.mit.edu	37	X	100387418	100387418	+	Silent	SNP	C	G	G			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chrX:100387418C>G	uc004egx.2	+	14	1713	c.1443C>G	c.(1441-1443)CTC>CTG	p.L481L	CENPI_uc011mrg.1_Silent_p.L481L|CENPI_uc004egy.2_Silent_p.L481L	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	481					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						TAGCGCAGCTCTTCTTTACAT	0.323													12	222					0	0	0.119110	0	0
COL4A5	1287	broad.mit.edu	37	X	107802363	107802363	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chrX:107802363C>T	uc004enz.1	+	3	413	c.211C>T	c.(211-213)CCG>TCG	p.P71S	COL4A5_uc011mso.1_Missense_Mutation_p.P71S	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	71	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						AGAAGGGCCTCCGGGGCCTCG	0.473									Alport_syndrome_with_Diffuse_Leiomyomatosis				19	207					0	0	0.062417	0	0
THOC2	57187	broad.mit.edu	37	X	122745309	122745309	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chrX:122745309C>T	uc004etu.2	-	37	4768	c.4736G>A	c.(4735-4737)GGA>GAA	p.G1579E	THOC2_uc004etv.3_5'Flank|THOC2_uc010nqt.1_RNA|THOC2_uc004etw.1_Missense_Mutation_p.G400E	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1579	Lys-rich.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						CTCTTCCTTTCCTCCTGAACT	0.353													34	162					0	0	0.069456	0	0
ODZ1	10178	broad.mit.edu	37	X	123838977	123838977	+	Missense_Mutation	SNP	A	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chrX:123838977A>T	uc004euj.2	-	5	965	c.901T>A	c.(901-903)TCC>ACC	p.S301T	ODZ1_uc011muj.1_Missense_Mutation_p.S301T|ODZ1_uc010nqy.2_Missense_Mutation_p.S301T	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	301	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GCAGGTCGGGAAAAGGTGCTT	0.527													61	272					0	0	0.139131	0	0
BCORL1	63035	broad.mit.edu	37	X	129155081	129155081	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chrX:129155081C>T	uc004evb.1	+	5	3677	c.3563C>T	c.(3562-3564)CCG>CTG	p.P1188L	BCORL1_uc010nrd.1_Missense_Mutation_p.P1090L	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1188					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						CCGACAAAGCCGGAGTCCCAG	0.632													10	21					0	0	0.080935	0	0
CXorf48	54967	broad.mit.edu	37	X	134292176	134292176	+	Nonsense_Mutation	SNP	G	C	C			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chrX:134292176G>C	uc004eyk.1	-	4	1141	c.485C>G	c.(484-486)TCA>TGA	p.S162*	CXorf48_uc004eyl.1_Nonsense_Mutation_p.S162*	NM_001031705	NP_001026875	Q8WUE5	CX048_HUMAN	hypothetical protein LOC54967 isoform 1	162											0	Acute lymphoblastic leukemia(192;0.000127)					CTTGATGTTTGAGATGCCTGG	0.428													4	125					0	0	0.021553	0	0
FLNA	2316	broad.mit.edu	37	X	153582588	153582588	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chrX:153582588C>T	uc004fkk.2	-	34	5737	c.5488G>A	c.(5488-5490)GTG>ATG	p.V1830M	FLNA_uc004fki.2_5'Flank|FLNA_uc011mzn.1_Missense_Mutation_p.V21M|FLNA_uc010nuu.1_Missense_Mutation_p.V1822M	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1830	Filamin 16.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCATACCGCACGGTCACGGTG	0.652													14	45					0	0	0.119110	0	0
Unknown	0	broad.mit.edu	37	1	113433615	113433616	+	IGR	INS	-	T	T			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:113433615_113433616insT								FAM19A3 (163761 upstream) : SLC16A1 (20856 downstream)																							ttattcacttattttttttttt	0.208													4	9	---	---	---	---					
DENND4B	9909	broad.mit.edu	37	1	153912718	153912722	+	Frame_Shift_Del	DEL	TTCTT	-	-			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr1:153912718_153912722delTTCTT	uc001fdd.1	-	11	1914_1918	c.1513_1517delAAGAA	c.(1513-1518)AAGAAGfs	p.K505fs		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	505_506										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGAGAGGAGCTTCTTTTCCTCAGTC	0.585													19	33	---	---	---	---					
Unknown	0	broad.mit.edu	37	10	94985788	94985789	+	IGR	INS	-	T	T	rs140557797	by1000genomes	TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr10:94985788_94985789insT								CYP26A1 (148147 upstream) : MYOF (80398 downstream)																							cccagagggagtgttacagtgc	0.000													2	4	---	---	---	---					
CASP5	838	broad.mit.edu	37	11	104879687	104879687	+	Frame_Shift_Del	DEL	T	-	-			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr11:104879687delT	uc010rva.1	-	2	60	c.28delA	c.(28-30)AGGfs	p.R10fs	CASP5_uc010ruz.1_Frame_Shift_Del_p.R23fs|CASP5_uc010rvb.1_Intron|CASP5_uc010rvc.1_Intron|CASP5_uc009yxh.2_Intron|CASP5_uc010rvd.1_Intron	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	10					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		TTCTTACGCCTTTTTTTTTTG	0.388													7	51	---	---	---	---					
VWF	7450	broad.mit.edu	37	12	6062680	6062682	+	In_Frame_Del	DEL	TCC	-	-			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr12:6062680_6062682delTCC	uc001qnn.1	-	48	8216_8218	c.7966_7968delGGA	c.(7966-7968)GGAdel	p.G2656del	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2656					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	TCATGATCTGTCCTCCTCTTAGC	0.463													90	60	---	---	---	---					
Unknown	0	broad.mit.edu	37	16	60214848	60214855	+	IGR	DEL	TTCCGTCT	-	-	rs71979129		TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr16:60214848_60214855delTTCCGTCT								None (None upstream) : None (None downstream)																							ccttccttccttccgtctgtctgtctgt	0.000													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	18	72057053	72057054	+	IGR	INS	-	T	T	rs79986462		TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr18:72057053_72057054insT								CYB5A (97832 upstream) : FAM69C (45910 downstream)																							ttattttattattatttttttt	0.158													4	6	---	---	---	---					
Unknown	0	broad.mit.edu	37	20	22713371	22713371	+	IGR	DEL	T	-	-			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr20:22713371delT								FOXA2 (147270 upstream) : SSTR4 (302686 downstream)																							tctaagttagtttTTTTTTGA	0.219													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	20	62737123	62737125	+	IGR	DEL	CGT	-	-	rs116947278	by1000genomes	TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr20:62737123_62737125delCGT								OPRL1 (5132 upstream) : NPBWR2 (59 downstream)																							tgatgatgggcgtgatgatgatg	0.212													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	3	88752126	88752141	+	IGR	DEL	TTCCTTCCTTCCTTCC	-	-	rs66786643	by1000genomes	TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr3:88752126_88752141delTTCCTTCCTTCCTTCC								C3orf38 (545013 upstream) : EPHA3 (404533 downstream)																							ccttccttctttccttccttccttccttccttcctt	0.102													3	3	---	---	---	---					
Unknown	0	broad.mit.edu	37	3	196395222	196395223	+	IGR	DEL	AG	-	-			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr3:196395222_196395223delAG								LRRC33 (6350 upstream) : C3orf34 (37926 downstream)																							agaaagagaaagagagagagag	0.064													4	5	---	---	---	---					
Unknown	0	broad.mit.edu	37	5	6571881	6571884	+	IGR	DEL	GAAG	-	-			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr5:6571881_6571884delGAAG								UBE2QL1 (79176 upstream) : LOC255167 (10403 downstream)																							agggaggagagaaggaaggaagga	0.000													5	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	5	122973171	122973176	+	IGR	DEL	AAAAAA	-	-			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chr5:122973171_122973176delAAAAAA								CSNK1G3 (20709 upstream) : ZNF608 (999434 downstream)																							ATTGGATGTCaaaaaaaaaaaaaaaa	0.243													2	4	---	---	---	---					
NR0B1	190	broad.mit.edu	37	X	30328948	30328948	+	5'Flank	DEL	T	-	-			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chrX:30328948delT	uc004dcf.3	-							NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1						adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	ccttccttcctttccttcctt	0.060													3	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	X	53063295	53063298	+	IGR	DEL	GAGG	-	-			TCGA-C5-A1MF-01A-11D-A13W-08	TCGA-C5-A1MF-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	e41f57b5-3eb4-457e-82f6-714267f4f393	2246aadd-79f9-4671-8a35-621949e4b23e	g.chrX:53063295_53063298delGAGG								FAM156A (125712 upstream) : GPR173 (15208 downstream)																							gggagggagcgagggagggaggga	0.000													2	4	---	---	---	---					
