Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HRNR	388697	broad.mit.edu	37	1	152188528	152188528	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:152188528G>A	ENST00000368801.2	-	3	5652	c.5577C>T	c.(5575-5577)ggC>ggT	p.G1859G	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1859					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCCATGTCGGCCACTGCTGG	0.597000													85	890					0	0	1	0	0
HDAC8	55869	broad.mit.edu	37	X	71787851	71787851	+	Missense_Mutation	SNP	A	A	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:71787851A>T	ENST00000439122.2	-	4	611	c.325T>A	c.(325-327)Ttt>Att	p.F109I	HDAC8_ENST00000429103.2_Intron|HDAC8_ENST00000373561.4_Missense_Mutation_p.F109I|HDAC8_ENST00000373554.1_Missense_Mutation_p.F109I|HDAC8_ENST00000478743.1_Intron|HDAC8_ENST00000373556.3_Missense_Mutation_p.F109I|HDAC8_ENST00000373573.3_Missense_Mutation_p.F109I|HDAC8_ENST00000373583.1_Intron|HDAC8_ENST00000373589.4_Intron|HDAC8_ENST00000373571.1_Missense_Mutation_p.F109I|HDAC8_ENST00000373559.4_Intron|HDAC8_ENST00000373560.2_Missense_Mutation_p.F109I	NM_001166419.1	NP_001159891.1	Q9BY41	HDAC8_HUMAN	histone deacetylase 8	109	Histone deacetylase.				chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			breast(3)|cervix(1)|endometrium(1)|lung(4)|prostate(1)	10	Renal(35;0.156)				Vorinostat(DB02546)	GCATAGTCAAATATCCCTTCA	0.478000													34	64					0	0	1	0	0
ARHGAP10	79658	broad.mit.edu	37	4	148984433	148984433	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:148984433C>T	ENST00000336498.3	+	21	2401	c.2162C>T	c.(2161-2163)gCg>gTg	p.A721V	ARHGAP10_ENST00000414545.2_Intron	NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	721					apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		GCTACTGTAGCGGACAAGCCA	0.532000													18	29					0	0	1	0	0
E2F1	1869	broad.mit.edu	37	20	32267721	32267721	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:32267721G>A	ENST00000343380.5	-	3	551	c.412C>T	c.(412-414)Cgc>Tgc	p.R138C		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	138					apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						TCCAGGAAGCGCTTGGTGGTC	0.602000													32	60					0	0	1	0	0
PTEN	5728	broad.mit.edu	37	10	89692910	89692910	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:89692910G>A	ENST00000371953.3	+	5	1751	c.394G>A	c.(394-396)Ggt>Agt	p.G132S		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	132	Phosphatase tensin-type.		G -> V (in one patient with clinical findings suggesting hamartoma tumor syndrome).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(5)|p.R55fs*1(5)|p.G132S(3)|p.Y27fs*1(2)|p.A121_F145del(1)|p.R130fs*2(1)|p.T131fs*42(1)|p.F56fs*2(1)|p.K128fs*47(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GGGACGAACTGGTGTAATGAT	0.398000		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			122	79					0	0	1	0	0
RPA4	29935	broad.mit.edu	37	X	96139445	96139445	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:96139445G>A	ENST00000373040.3	+	1	539	c.136G>A	c.(136-138)Gtt>Att	p.V46I	DIAPH2_ENST00000373049.4_Intron|DIAPH2_ENST00000355827.4_Intron|DIAPH2_ENST00000373054.4_Intron|DIAPH2_ENST00000373061.3_Intron|DIAPH2_ENST00000324765.8_Intron	NM_013347.4	NP_037479.1	Q13156	RFA4_HUMAN	replication protein A4, 30kDa	46					DNA damage checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair	DNA replication factor A complex|nucleoplasm	single-stranded DNA binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	13						AATTCAGGACGTTGTACCGTG	0.498000								Other identified genes with known or suspected DNA repair function					38	40					0	0	1	0	0
B3GNT1	11041	broad.mit.edu	37	11	66114163	66114163	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:66114163C>A	ENST00000311181.4	-	1	1000	c.854G>T	c.(853-855)cGg>cTg	p.R285L		NM_006876.2	NP_006867.1	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1	285					poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|kidney(1)|large_intestine(2)|lung(6)|urinary_tract(1)	12						ATAGAAGGGCCGCACCTCGCC	0.632000													52	58					3.76525e-18	4.10201e-18	1	1	0
GRM5	2915	broad.mit.edu	37	11	88386450	88386450	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:88386450G>A	ENST00000418177.2	-	4	1400	c.1033C>T	c.(1033-1035)Cgg>Tgg	p.R345W	GRM5_ENST00000455756.2_Missense_Mutation_p.R345W|GRM5_ENST00000305432.5_Missense_Mutation_p.R345W|GRM5_ENST00000393297.1_Missense_Mutation_p.R345W|GRM5_ENST00000305447.4_Missense_Mutation_p.R345W			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	345					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GTTTCTGGCCGGAGCTTCAGA	0.458000													46	47					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54625988	54625988	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:54625988T>C	ENST00000545554.1	+	15	4518	c.4518T>C	c.(4516-4518)acT>acC	p.T1506T	UNC13C_ENST00000260323.11_Silent_p.T1506T|UNC13C_ENST00000537900.1_Silent_p.T1504T			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1506					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CAAGCAATACTGAAAGACTGC	0.348000													7	13					0	0	1	0	0
NUAK2	81788	broad.mit.edu	37	1	205290640	205290640	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:205290640C>T	ENST00000367157.3	-	1	243	c.117G>A	c.(115-117)gcG>gcA	p.A39A		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	39					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GCCGCTTCACCGCCTGCTTCT	0.672000													3	45					0	0	1	0	0
RBM41	55285	broad.mit.edu	37	X	106332030	106332030	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:106332030T>C	ENST00000372487.1	-	5	589	c.563A>G	c.(562-564)aAc>aGc	p.N188S	RBM41_ENST00000372479.3_Missense_Mutation_p.N188S|RBM41_ENST00000203616.8_Missense_Mutation_p.N212S	NM_001171080.1	NP_001164551.1	Q96IZ5	RBM41_HUMAN	RNA binding motif protein 41	188							nucleotide binding|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	13						ACTTTCCAGGTTGTTCATGGG	0.408000													31	45					0	0	1	0	0
MKL2	57496	broad.mit.edu	37	16	14355246	14355246	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:14355246G>A	ENST00000571589.1	+	17	3417	c.3245G>A	c.(3244-3246)aGc>aAc	p.S1082N	MKL2_ENST00000318282.5_Missense_Mutation_p.S1032N|MKL2_ENST00000341243.5_Missense_Mutation_p.S1071N|MKL2_ENST00000574045.1_Missense_Mutation_p.S1032N	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	1071					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ACCGCGCCGAGCATGTTCTCT	0.507000													35	45					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120190012	120190012	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:120190012C>T	ENST00000392521.2	-	23	2802	c.2747G>A	c.(2746-2748)cGc>cAc	p.R916H	CIT_ENST00000261833.7_Missense_Mutation_p.R874H|CIT_ENST00000537607.1_5'UTR	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	874					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TGTGAGCTGGCGCTTGAGCTC	0.582000													19	17					0	0	1	0	0
ZNF671	79891	broad.mit.edu	37	19	58232447	58232447	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:58232447G>A	ENST00000317398.6	-	4	1102	c.1007C>T	c.(1006-1008)aCt>aTt	p.T336I	ZNF671_ENST00000335820.3_Missense_Mutation_p.T238I|AC003006.7_ENST00000599221.1_Intron	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	336					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CCTTTCTCCAGTGTGAACTGT	0.463000													32	83					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19959451	19959451	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:19959451G>A	ENST00000263207.3	-	18	3030	c.2739C>T	c.(2737-2739)ggC>ggT	p.G913G	ARVCF_ENST00000344269.3_Silent_p.G850G|ARVCF_ENST00000406522.1_Silent_p.G844G|ARVCF_ENST00000406259.1_Silent_p.G907G|ARVCF_ENST00000401994.1_Silent_p.G850G	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	913					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					CAGAGCTGGCGCCCCGTGGCC	0.652000													22	40					0	0	1	0	0
ERICH1	157697	broad.mit.edu	37	8	623411	623411	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:623411C>T	ENST00000262109.7	-	4	1018	c.941G>A	c.(940-942)gGt>gAt	p.G314D	ERICH1_ENST00000522706.1_Missense_Mutation_p.G220D	NM_207332.1	NP_997215.1	Q86X53	ERIC1_HUMAN	glutamate-rich 1	314	Glu-rich.									endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)	20		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		GGAGTCTGCACCCTCTTCCTC	0.567000													62	229					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42162110	42162110	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:42162110G>A	ENST00000320955.6	-	32	6009	c.5782C>T	c.(5782-5784)Ctg>Ttg	p.L1928L		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1928					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CGTCGCTGCAGCACTGCCCAC	0.701000													6	4					0	0	1	0	0
ENPP1	5167	broad.mit.edu	37	6	132171156	132171156	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:132171156G>A	ENST00000360971.2	+	3	360	c.340G>A	c.(340-342)Gag>Aag	p.E114K		NM_006208.2	NP_006199.2	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 1	114	SMB 1.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity	p.E62*(1)		autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TCGCTGTTTCGAGAGAACATT	0.383000													67	53					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17292527	17292527	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:17292527C>T	ENST00000375541.5	+	29	4678	c.4609C>T	c.(4609-4611)Cgc>Tgc	p.R1537C		NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	1537					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		TGCCCTGAATCGCCAGCTGGC	0.637000													26	38					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106121801	106121801	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:106121801G>T	ENST00000369704.3	+	3	446	c.312G>T	c.(310-312)aaG>aaT	p.K104N	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	104										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		AGGCCTGGAAGATGGTGGACT	0.448000													42	26					3.77016e-25	4.20665e-25	1	1	0
NUB1	51667	broad.mit.edu	37	7	151046250	151046250	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:151046250G>A	ENST00000568733.1	+	3	347	c.281G>A	c.(280-282)cGt>cAt	p.R94H	NUB1_ENST00000566856.1_Missense_Mutation_p.R70H|NUB1_ENST00000413040.2_Missense_Mutation_p.R94H|NUB1_ENST00000355851.4_Missense_Mutation_p.R70H			Q9Y5A7	NUB1_HUMAN	negative regulator of ubiquitin-like proteins 1	70					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	nucleus	protein binding			endometrium(1)|large_intestine(7)|lung(3)	11			OV - Ovarian serous cystadenocarcinoma(82;0.00569)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		GCAATTGAGCGTGGAACAGGA	0.373000													38	56					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228474715	228474715	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:228474715C>T	ENST00000570156.2	+	40	10880	c.10806C>T	c.(10804-10806)tgC>tgT	p.C3602C	OBSCN_ENST00000366709.4_Silent_p.C292C|OBSCN_ENST00000284548.11_Silent_p.C3173C|OBSCN_ENST00000359599.6_Silent_p.C2020C|OBSCN_ENST00000422127.1_Silent_p.C3173C|OBSCN_ENST00000366707.4_Silent_p.C292C	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2635	Ig-like 36.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGGGCGCCTGCAGCAGCTCCA	0.652000													3	9					0	0	1	0	0
CFHR1	3078	broad.mit.edu	37	1	196799690	196799690	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:196799690C>T	ENST00000320493.5	+	5	756	c.668C>T	c.(667-669)cCg>cTg	p.P223L	CFHR2_ENST00000367421.3_Intron|CFHR1_ENST00000367424.3_Missense_Mutation_p.P164L	NM_002113.2	NP_002104.2	Q03591	FHR1_HUMAN	complement factor H-related 1	223	Sushi 4.				complement activation	extracellular space				NS(1)|kidney(1)|large_intestine(2)|lung(7)	11						ACTTCATTCCCGTTGTCAGTA	0.413000													57	8					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20974801	20974801	+	Nonsense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:20974801C>A	ENST00000261383.3	-	53	10404	c.10405G>T	c.(10405-10407)Gga>Tga	p.G3469*	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3469					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TTCTCCAATCCTTGAGAGAAC	0.512000													18	29					1.67942e-08	1.76178e-08	1	1	0
KMT2C	58508	broad.mit.edu	37	7	152055715	152055715	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:152055715C>T	ENST00000355193.2	-	2	425	c.207G>A	c.(205-207)atG>atA	p.M69I	KMT2C_ENST00000262189.6_Missense_Mutation_p.M69I					lysine (K)-specific methyltransferase 2C																		CCAGCCCATCCATGCTGTCCT	0.348000													65	105					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51258732	51258732	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:51258732G>T	ENST00000395542.2	-	4	684	c.500C>A	c.(499-501)gCt>gAt	p.A167D	COBL_ENST00000395540.2_Missense_Mutation_p.A167D|COBL_ENST00000265136.7_Missense_Mutation_p.A167D|COBL_ENST00000441453.1_Missense_Mutation_p.A167D			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	167										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					ACGCACAACAGCTTTTTGTGT	0.488000													8	30					0.000442599	0.000448739	1	1	0
DNASE2B	58511	broad.mit.edu	37	1	84880445	84880445	+	Missense_Mutation	SNP	G	G	A	rs145614783	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:84880445G>A	ENST00000370665.3	+	6	1013	c.980G>A	c.(979-981)cGg>cAg	p.R327Q	DNASE2B_ENST00000370662.3_Missense_Mutation_p.R119Q	NM_021233.2	NP_067056.2	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta	327					DNA metabolic process	lysosome	deoxyribonuclease II activity			endometrium(1)|lung(4)|skin(1)	6				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		GACCTAAATCGGAGTCCACAC	0.403000													33	32					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152738148	152738148	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:152738148G>T	ENST00000367255.5	-	41	6025	c.5424C>A	c.(5422-5424)gaC>gaA	p.D1808E	SYNE1_ENST00000448038.1_Missense_Mutation_p.D1815E|SYNE1_ENST00000423061.1_Missense_Mutation_p.D1815E|SYNE1_ENST00000265368.4_Missense_Mutation_p.D1808E|SYNE1_ENST00000341594.5_Missense_Mutation_p.D1845E	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1808					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGCTGCGTGGTCCTGGAAGG	0.483000										HNSCC(10;0.0054)			95	66					2.56585e-57	2.91483e-57	1	1	0
LINC00969	0	broad.mit.edu	37	3	195395468	195395468	+	RNA	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:195395468G>A	ENST00000445430.1	+	0	875																											ACCAGGGCAGGCCTTCCTTGC	0.612000													4	15					0	0	1	0	0
PSEN1	5663	broad.mit.edu	37	14	73637521	73637521	+	Missense_Mutation	SNP	G	G	A	rs63750592		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:73637521G>A	ENST00000324501.5	+	4	376	c.104G>A	c.(103-105)cGg>cAg	p.R35Q	PSEN1_ENST00000394164.1_Missense_Mutation_p.R31Q|PSEN1_ENST00000406768.1_5'UTR|PSEN1_ENST00000557511.1_Missense_Mutation_p.R35Q|PSEN1_ENST00000344094.3_Missense_Mutation_p.R35Q|PSEN1_ENST00000261970.3_Missense_Mutation_p.R35Q|PSEN1_ENST00000394157.3_Missense_Mutation_p.R35Q|PSEN1_ENST00000357710.4_Missense_Mutation_p.R31Q|PSEN1_ENST00000553447.2_3'UTR	NM_000021.3|NM_007318.2	NP_000012.1|NP_015557.2	P49768	PSN1_HUMAN	presenilin 1	35					amyloid precursor protein catabolic process|anti-apoptosis|beta-amyloid metabolic process|cell-cell adhesion|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|smooth endoplasmic reticulum calcium ion homeostasis	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|gamma-secretase complex|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum|smooth endoplasmic reticulum|Z disc	aspartic-type endopeptidase activity|beta-catenin binding|cadherin binding|calcium channel activity|PDZ domain binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.075)		AATAGAGAACGGCAGGAGCAC	0.478000													8	25					0	0	1	0	0
SLC25A42	284439	broad.mit.edu	37	19	19218753	19218753	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:19218753T>C	ENST00000318596.7	+	7	699	c.548T>C	c.(547-549)cTg>cCg	p.L183P	SLC25A42_ENST00000600275.1_3'UTR	NM_178526.4	NP_848621.2	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	183					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			GAAGAGGGGCTGAAGACTCTC	0.562000													118	88					0	0	1	0	0
ARL16	339231	broad.mit.edu	37	17	79650090	79650090	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:79650090T>C	ENST00000397498.4	-	3	357	c.259A>G	c.(259-261)Atg>Gtg	p.M87V	ARL16_ENST00000573392.1_Intron|ARL16_ENST00000574938.1_Intron|ARL16_ENST00000576135.1_Start_Codon_SNP_p.M1V|ARL16_ENST00000570561.1_Start_Codon_SNP_p.M1V	NM_001040025.1	NP_001035114.1	Q0P5N6	ARL16_HUMAN	ADP-ribosylation factor-like 16	87							GTP binding			central_nervous_system(1)|endometrium(1)|lung(4)|skin(1)	7	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			ATGGGGCCCATGCACCCCCCA	0.488000													22	207					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36365461	36365461	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:36365461G>A	ENST00000221891.4	+	9	1304	c.1112G>A	c.(1111-1113)cGc>cAc	p.R371H	APLP1_ENST00000586861.1_Missense_Mutation_p.R365H|APLP1_ENST00000589298.2_3'UTR|APLP1_ENST00000537454.2_Missense_Mutation_p.R332H	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	371					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGCGACAGCGCCTGGTGGAA	0.652000													75	86					0	0	1	0	0
CCDC144A	9720	broad.mit.edu	37	17	16593988	16593988	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:16593988G>A	ENST00000443444.2	+	1	414	c.274G>A	c.(274-276)Gac>Aac	p.D92N	CCDC144A_ENST00000360524.8_Missense_Mutation_p.D92N|RP11-219A15.1_ENST00000448331.3_Missense_Mutation_p.D92N|CCDC144A_ENST00000456009.1_Missense_Mutation_p.D92N|CCDC144A_ENST00000340621.5_Missense_Mutation_p.D92N|CCDC144A_ENST00000436374.1_3'UTR|CCDC144A_ENST00000399273.1_Missense_Mutation_p.D92N			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	92																	CCGGTCGGGCGACGTCCCTGG	0.642000													94	141					0	0	1	0	0
AP1G2	8906	broad.mit.edu	37	14	24033540	24033540	+	Splice_Site	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:24033540A>G	ENST00000308724.5	-	9	1733		c.e9+1		AP1G2_ENST00000397120.3_Splice_Site|RP11-66N24.3_ENST00000555968.1_RNA	NM_003917.2	NP_003908.1	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2 subunit						interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	28	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		TGGGACTATTACCTAATGTTC	0.512000													30	42					0	0	1	0	0
NOC2L	26155	broad.mit.edu	37	1	892379	892379	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:892379C>T	ENST00000327044.6	-	4	430	c.381G>A	c.(379-381)gcG>gcA	p.A127A	NOC2L_ENST00000487214.1_5'UTR	NM_015658.3	NP_056473.2	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog (S. cerevisiae)	127						nucleolus	protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	16	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		CTCCTTCCTCCGCTCCATCCT	0.582000													79	103					0	0	1	0	0
GPR124	25960	broad.mit.edu	37	8	37693106	37693106	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:37693106C>T	ENST00000412232.2	+	13	1881	c.1868C>T	c.(1867-1869)cCg>cTg	p.P623L	GPR124_ENST00000315215.7_Intron	NM_032777.9	NP_116166.9	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	623					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CAGCTGCCCCCGAGTCTATTC	0.647000													82	298					0	0	1	0	0
PGM5	5239	broad.mit.edu	37	9	70993145	70993145	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:70993145A>G	ENST00000396396.1	+	2	521	c.292A>G	c.(292-294)Atc>Gtc	p.I98V	PGM5_ENST00000604870.2_3'UTR|PGM5_ENST00000396392.1_Missense_Mutation_p.I98V	NM_021965.3	NP_068800.2	Q15124	PGM5_HUMAN	phosphoglucomutase 5	98					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity	p.I98V(3)		endometrium(5)|kidney(1)|large_intestine(5)|liver(2)|lung(15)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	34						ACAGAATGGCATCTTGTCGAC	0.478000													5	70					0	0	1	0	0
EHF	26298	broad.mit.edu	37	11	34668216	34668216	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:34668216C>T	ENST00000257831.3	+	3	449	c.328C>T	c.(328-330)Cat>Tat	p.H110Y	EHF_ENST00000530286.1_Missense_Mutation_p.H110Y|EHF_ENST00000531728.1_Missense_Mutation_p.H110Y|EHF_ENST00000527935.1_Missense_Mutation_p.H110Y|EHF_ENST00000531794.1_Missense_Mutation_p.H132Y|EHF_ENST00000533754.1_Missense_Mutation_p.H110Y|EHF_ENST00000450654.2_Missense_Mutation_p.H110Y	NM_012153.5	NP_036285.2	Q9NZC4	EHF_HUMAN	ets homologous factor	110	PNT.				cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		NFIA/EHF(2)	autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|lung(8)|upper_aerodigestive_tract(1)	17		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			CAACTTGCAGCATCTGAAGTG	0.552000													97	140					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123348433	123348433	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:123348433C>T	ENST00000360304.3	-	30	5283	c.5002G>A	c.(5002-5004)Gaa>Aaa	p.E1668K	MYLK_ENST00000359169.1_Intron|MYLK_ENST00000360772.3_Intron|MYLK-AS1_ENST00000463408.1_RNA|MYLK_ENST00000354792.5_Missense_Mutation_p.E468K|MYLK-AS1_ENST00000485162.1_RNA|MYLK_ENST00000346322.5_Missense_Mutation_p.E1599K|MYLK_ENST00000475616.1_Missense_Mutation_p.E1668K|MYLK-AS1_ENST00000470449.1_RNA	NM_053025.3	NP_444253.3	Q15746	MYLK_HUMAN	myosin light chain kinase	1668	Protein kinase.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GCCAAGGTTTCGTTATCGTTG	0.557000													38	35					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40980772	40980772	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:40980772T>C	ENST00000373198.3	-	10	1949	c.1714A>G	c.(1714-1716)Aag>Gag	p.K572E	PTPRT_ENST00000373187.1_Missense_Mutation_p.K572E|PTPRT_ENST00000373190.1_Missense_Mutation_p.K572E|PTPRT_ENST00000373193.3_Missense_Mutation_p.K572E|PTPRT_ENST00000373201.1_Missense_Mutation_p.K572E|PTPRT_ENST00000373184.1_Missense_Mutation_p.K572E|PTPRT_ENST00000356100.2_Missense_Mutation_p.K572E	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	572	Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCAAAGCCCTTTGCTGTGCTG	0.517000													48	101					0	0	1	0	0
CENPT	80152	broad.mit.edu	37	16	67863714	67863714	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:67863714G>A	ENST00000562787.1	-	12	1688	c.1140C>T	c.(1138-1140)gaC>gaT	p.D380D	CENPT_ENST00000219172.3_Silent_p.D380D|CENPT_ENST00000564817.1_Intron|CENPT_ENST00000440851.2_Silent_p.D380D	NM_025082.3	NP_079358.3	Q96BT3	CENPT_HUMAN	centromere protein T	380					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding			NS(1)|breast(2)|lung(6)|urinary_tract(1)	10		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		CTCCTGGCCCGTCAGCCTCAG	0.612000													72	82					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123419539	123419539	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:123419539G>A	ENST00000360772.3	-	19	3154	c.2776C>T	c.(2776-2778)Cgt>Tgt	p.R926C	MYLK_ENST00000359169.1_Missense_Mutation_p.R926C|MYLK_ENST00000360304.3_Missense_Mutation_p.R926C|MYLK_ENST00000346322.5_Missense_Mutation_p.R857C|MYLK_ENST00000475616.1_Missense_Mutation_p.R926C			Q15746	MYLK_HUMAN	myosin light chain kinase	926	5 X 28 AA approximate tandem repeats.|Actin-binding (calcium/calmodulin- sensitive) (By similarity).				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		AGGTTGGCACGGAAATCCATC	0.572000													37	54					0	0	1	0	0
PCDHGB1	0	broad.mit.edu	37	5	140730213	140730213	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140730213G>A	ENST00000523390.1	+	1	386	c.386G>A	c.(385-387)cGt>cAt	p.R129H	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATGCACCACGTTTCGTTGCA	0.418000													35	77					0	0	1	0	0
NARG2	79664	broad.mit.edu	37	15	60747588	60747588	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:60747588C>A	ENST00000261520.4	-	7	954	c.720G>T	c.(718-720)caG>caT	p.Q240H	NARG2_ENST00000561114.1_Missense_Mutation_p.Q240H|NARG2_ENST00000439632.1_Missense_Mutation_p.Q103H	NM_024611.4	NP_078887.2	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2	240						nucleus				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	32						CCTTTGACAGCTGCAACTTTA	0.333000													53	56					1.10885e-35	1.24515e-35	1	1	0
MAPK15	225689	broad.mit.edu	37	8	144800992	144800992	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:144800992G>A	ENST00000338033.4	+	5	453	c.334G>A	c.(334-336)Gtc>Atc	p.V112I	RP11-429J17.5_ENST00000527908.1_RNA|MAPK15_ENST00000395108.2_Missense_Mutation_p.V112I|MAPK15_ENST00000395107.4_Missense_Mutation_p.V129I	NM_139021.2	NP_620590.2	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	112	Protein kinase.				protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|stomach(1)	12	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GCTGCAGGACGTCCACGTGCG	0.692000													14	33					0	0	1	0	0
KDM5C	8242	broad.mit.edu	37	X	53247577	53247577	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:53247577G>T	ENST00000375401.3	-	3	764	c.232C>A	c.(232-234)Cag>Aag	p.Q78K	KDM5C_ENST00000375379.3_Missense_Mutation_p.Q78K|KDM5C_ENST00000404049.3_Missense_Mutation_p.Q78K|KDM5C_ENST00000452825.3_Intron|KDM5C_ENST00000375383.3_Intron	NM_004187.3	NP_004178.2	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	78					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						ACTCTCGTCTGGGCCTGAAGA	0.512000			"""N, F, S"""		clear cell renal carcinoma								24	48					2.49675e-24	2.77874e-24	1	1	0
DVL3	1857	broad.mit.edu	37	3	183888361	183888361	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:183888361G>A	ENST00000313143.3	+	15	2217	c.1969G>A	c.(1969-1971)Gga>Aga	p.G657R	DVL3_ENST00000431765.1_Missense_Mutation_p.G640R|EIF2B5_ENST00000444495.1_Intron	NM_004423.3	NP_004414.3	Q92997	DVL3_HUMAN	dishevelled segment polarity protein 3	657					canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(6)|liver(1)|lung(13)|ovary(1)|prostate(1)	35	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			CGGTCCTCCCGGAGTGCCCCC	0.746000													19	13					0	0	1	0	0
HECTD2	143279	broad.mit.edu	37	10	93221892	93221892	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:93221892G>T	ENST00000446394.1	+	5	651	c.551G>T	c.(550-552)gGg>gTg	p.G184V	HECTD2_ENST00000371681.4_Missense_Mutation_p.G184V|HECTD2_ENST00000298068.5_Missense_Mutation_p.G184V			Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	184					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						GAAGACTCTGGGATTAATGCT	0.294000													43	164					2.64894e-19	2.91118e-19	1	1	0
NKPD1	284353	broad.mit.edu	37	19	45655971	45655971	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:45655971G>A	ENST00000317951.4	-	4	1723	c.1724C>T	c.(1723-1725)gCg>gTg	p.A575V	NKPD1_ENST00000589776.1_Missense_Mutation_p.A353V|NKPD1_ENST00000429338.1_Missense_Mutation_p.A353V|NKPD1_ENST00000438936.2_Missense_Mutation_p.A353V	NM_198478.3	NP_940880.3			NTPase, KAP family P-loop domain containing 1											endometrium(1)|lung(4)|prostate(2)|urinary_tract(1)	8		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		CGCCTGCACCGCCAGCAGCTG	0.741000													5	8					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94899379	94899379	+	Missense_Mutation	SNP	G	G	A	rs142627007	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:94899379G>A	ENST00000357742.4	+	8	1019	c.1019G>A	c.(1018-1020)cGc>cAc	p.R340H	MCTP2_ENST00000543482.1_Missense_Mutation_p.R340H|MCTP2_ENST00000557742.1_5'UTR|MCTP2_ENST00000451018.3_Missense_Mutation_p.R340H|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	340					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TCTTTGATACGCAACCTACGG	0.388000													37	75					0	0	1	0	0
RNF165	494470	broad.mit.edu	37	18	44036491	44036491	+	Silent	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:44036491C>A	ENST00000269439.7	+	8	984	c.933C>A	c.(931-933)ccC>ccA	p.P311P	RNF165_ENST00000543885.1_Silent_p.P119P	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	311							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		GACGCCTACCCTGTATGCATC	0.592000													52	70					1.17673e-23	1.30632e-23	1	1	0
PCDHB15	0	broad.mit.edu	37	5	140627364	140627364	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140627364A>G	ENST00000231173.3	+	1	2218	c.2218A>G	c.(2218-2220)Agc>Ggc	p.S740G		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		740					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGGACGTGAGCGGCACCGG	0.602000													207	134					0	0	1	0	0
DDN	23109	broad.mit.edu	37	12	49392006	49392006	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:49392006C>T	ENST00000421952.2	-	2	674	c.653G>A	c.(652-654)cGa>cAa	p.R218Q		NM_015086.1	NP_055901.2	O94850	DEND_HUMAN	dendrin	218	Interaction with MAGI2.					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				NS(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	8						CCAGCGGCGTCGTGGGGCGGT	0.716000													27	40					0	0	1	0	0
MAPK8IP2	23542	broad.mit.edu	37	22	51043378	51043378	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:51043378G>A	ENST00000399908.2	+	3	1569	c.853G>A	c.(853-855)Gcg>Acg	p.A285T	MAPK8IP2_ENST00000442429.2_Intron|MAPK8IP2_ENST00000399912.1_Missense_Mutation_p.A285T|MAPK8IP2_ENST00000341339.4_Missense_Mutation_p.A171T|MAPK8IP2_ENST00000329492.3_Missense_Mutation_p.A550T|MAPK8IP2_ENST00000008876.5_Missense_Mutation_p.A256T	NM_016431.3	NP_057515.1	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting protein 2	551	Ser-rich.				behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGAGGCGGGCGCGGCGCTGCT	0.682000													22	20					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186567832	186567832	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:186567832T>C	ENST00000431808.1	-	11	1237	c.674A>G	c.(673-675)cAt>cGt	p.H225R	SORBS2_ENST00000449407.2_Missense_Mutation_p.H296R|SORBS2_ENST00000448662.2_Missense_Mutation_p.H294R|SORBS2_ENST00000437304.2_Missense_Mutation_p.H404R|SORBS2_ENST00000418609.1_Missense_Mutation_p.H129R|SORBS2_ENST00000498125.1_5'UTR|SORBS2_ENST00000393528.3_Missense_Mutation_p.H271R|SORBS2_ENST00000355634.5_Missense_Mutation_p.H325R|SORBS2_ENST00000319471.9_Missense_Mutation_p.H311R|SORBS2_ENST00000284776.7_Missense_Mutation_p.H225R			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	225						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TGGTCTTTCATGCTGAAGAAT	0.438000													29	33					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92624210	92624210	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:92624210C>T	ENST00000298047.6	+	27	13718	c.13701C>T	c.(13699-13701)agC>agT	p.S4567S	FAT3_ENST00000409404.2_Silent_p.S4535S|FAT3_ENST00000525166.1_Silent_p.S4417S|FAT3_ENST00000533797.1_Silent_p.S870S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4567					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACTACGAGAGCGTGGGAGAGC	0.527000										TCGA Ovarian(4;0.039)			8	14					0	0	1	0	0
S100A13	6284	broad.mit.edu	37	1	153591516	153591516	+	Splice_Site	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:153591516T>C	ENST00000368699.1	-	5	657		c.e5-2		S100A13_ENST00000339556.4_Splice_Site|S100A13_ENST00000491177.1_Splice_Site|S100A13_ENST00000392623.1_Splice_Site|S100A13_ENST00000440685.2_Splice_Site|S100A13_ENST00000392622.1_Splice_Site	NM_001024210.1	NP_001019381.1	Q99584	S10AD_HUMAN	S100 calcium binding protein A13						interleukin-1 alpha secretion|mast cell degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|extracellular space|nucleus|perinuclear region of cytoplasm	calcium ion binding|copper ion binding|fibroblast growth factor 1 binding|lipid binding|protein homodimerization activity|RAGE receptor binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(4)	7	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)		Amlexanox(DB01025)	GCCCACATCCTGAGGAGACAC	0.502000													101	112					0	0	1	0	0
G6PD	2539	broad.mit.edu	37	X	153762334	153762334	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:153762334T>C	ENST00000393562.2	-	7	1159	c.776A>G	c.(775-777)aAc>aGc	p.N259S	G6PD_ENST00000369620.2_Missense_Mutation_p.N229S|G6PD_ENST00000393564.2_Missense_Mutation_p.N229S	NM_000402.3	NP_000393.4	P11413	G6PD_HUMAN	glucose-6-phosphate dehydrogenase	229					cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(3)|ovary(4)	18	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCAGGCGATGTTGTCCCGGTT	0.587000													39	69					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25464418	25464418	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:25464418C>T	ENST00000376351.3	+	1	428	c.69C>T	c.(67-69)ggC>ggT	p.G23G	GPR158-AS1_ENST00000449643.1_RNA	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	23						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GAGCTGTTGGCGCCAGCCGCG	0.667000													35	92					0	0	1	0	0
FAM168B	130074	broad.mit.edu	37	2	131812977	131812977	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:131812977C>T	ENST00000409185.1	-	5	450	c.343G>A	c.(343-345)Gtc>Atc	p.V115I	FAM168B_ENST00000389915.3_Missense_Mutation_p.V115I	NM_001009993.2	NP_001009993.2	A1KXE4	F168B_HUMAN	family with sequence similarity 168, member B	115										endometrium(3)|lung(2)	5						TGGTGGATGACGTGAGGAGGT	0.612000													59	106					0	0	1	0	0
TBC1D16	125058	broad.mit.edu	37	17	77984212	77984212	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:77984212C>T	ENST00000310924.2	-	3	641	c.526G>A	c.(526-528)Gcc>Acc	p.A176T		NM_001271844.1|NM_001271845.1|NM_019020.2	NP_001258773.1|NP_001258774.1|NP_061893.2	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	176						intracellular	Rab GTPase activator activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(3)	28	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			GGCTGCGAGGCTGGCTGGGCA	0.706000													6	27					0	0	1	0	0
SHPRH	257218	broad.mit.edu	37	6	146209222	146209222	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:146209222T>C	ENST00000367503.3	-	29	5299	c.4901A>G	c.(4900-4902)cAc>cGc	p.H1634R	SHPRH_ENST00000438092.2_Missense_Mutation_p.H1634R|SHPRH_ENST00000275233.7_Missense_Mutation_p.H1630R|SHPRH_ENST00000367505.2_Missense_Mutation_p.H1630R	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	1630	Helicase C-terminal.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TAAGAATCTGTGTACAATAGT	0.323000													9	34					0	0	1	0	0
WWOX	51741	broad.mit.edu	37	16	78458772	78458772	+	Missense_Mutation	SNP	T	T	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:78458772T>G	ENST00000566780.1	+	7	977	c.611T>G	c.(610-612)cTt>cGt	p.L204R	WWOX_ENST00000406884.2_Intron|WWOX_ENST00000408984.3_Missense_Mutation_p.L204R|WWOX_ENST00000402655.2_Intron|WWOX_ENST00000539474.2_Intron	NM_016373.2	NP_057457.1	Q9NZC7	WWOX_HUMAN	WW domain containing oxidoreductase	204	Interaction with MAPT (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	7		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		TTCAGGCCTCTTCATGTGCTT	0.463000													31	337					0	0	1	0	0
MYCT1	80177	broad.mit.edu	37	6	153043291	153043291	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:153043291G>A	ENST00000367245.5	+	2	619	c.611G>A	c.(610-612)cGt>cAt	p.R204H	MYCT1_ENST00000529453.1_Intron	NM_025107.2	NP_079383.2	Q8N699	MYCT1_HUMAN	myc target 1	204						nucleus		p.R204H(1)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	20		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		AGTCTGAGCCGTCCTGACTAC	0.532000													57	88					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10447381	10447381	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:10447381T>C	ENST00000326756.3	-	3	1010	c.572A>G	c.(571-573)cAg>cGg	p.Q191R		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						ATACTCACACTGATAAGGAAA	0.403000													71	73					0	0	1	0	0
TUBA3D	113457	broad.mit.edu	37	2	132236920	132236920	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:132236920C>T	ENST00000321253.6	+	3	373	c.266C>T	c.(265-267)cCg>cTg	p.P89L	TUBA3D_ENST00000409047.2_3'UTR	NM_080386.3	NP_525125.2	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	89					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		CTCTTCCACCCGGAGCAGCTG	0.527000													68	113					0	0	1	0	0
PTCH1	5727	broad.mit.edu	37	9	98238411	98238411	+	Nonsense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:98238411C>A	ENST00000430669.2	-	12	2020	c.1435G>T	c.(1435-1437)Gga>Tga	p.G479*	PTCH1_ENST00000437951.1_Nonsense_Mutation_p.G479*|PTCH1_ENST00000375274.2_Nonsense_Mutation_p.G544*|PTCH1_ENST00000418258.1_Nonsense_Mutation_p.G394*|PTCH1_ENST00000331920.6_Nonsense_Mutation_p.G545*|PTCH1_ENST00000421141.1_Nonsense_Mutation_p.G394*|PTCH1_ENST00000429896.2_Nonsense_Mutation_p.G394*			Q13635	PTC1_HUMAN	patched 1	545	SSD.				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				ACGCTGGCTCCTGTGCGCTTC	0.592000													13	11					1.5842e-08	1.66388e-08	1	1	0
TTLL12	23170	broad.mit.edu	37	22	43570304	43570304	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:43570304G>A	ENST00000216129.6	-	8	1203	c.1140C>T	c.(1138-1140)ggC>ggT	p.G380G		NM_015140.3	NP_055955.1	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	380	TTL.				protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	13		Ovarian(80;0.221)|Glioma(61;0.222)				GGCCCTCGGGGCCACCTGCCC	0.657000													67	124					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230223281	230223281	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:230223281G>A	ENST00000341772.4	-	13	2323	c.2189C>T	c.(2188-2190)aCa>aTa	p.T730I		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	730					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TTTAATCAGTGTGACCAAGGG	0.333000													32	30					0	0	1	0	0
TRPV3	162514	broad.mit.edu	37	17	3438974	3438974	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:3438974C>T	ENST00000301365.4	-	7	808	c.677G>A	c.(676-678)cGg>cAg	p.R226Q	TRPV3_ENST00000576742.1_Missense_Mutation_p.R226Q|TRPV3_ENST00000572519.1_Missense_Mutation_p.R226Q			Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel, subfamily V, member 3	226						integral to membrane	calcium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(12)|ovary(5)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	35					Menthol(DB00825)	GTCCCCCTGCCGCCGCTCGAT	0.721000													4	7					0	0	1	0	0
RNF150	57484	broad.mit.edu	37	4	142053668	142053668	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:142053668G>T	ENST00000306799.3	-	1	948	c.295C>A	c.(295-297)Cgc>Agc	p.R99S	RNF150_ENST00000515673.1_Missense_Mutation_p.R99S|RNF150_ENST00000420921.2_Intron|RNF150_ENST00000507500.1_Missense_Mutation_p.R99S	NM_020724.1	NP_065775.1	Q9ULK6	RN150_HUMAN	ring finger protein 150	99	PA.					integral to membrane	zinc ion binding			breast(1)|large_intestine(10)|lung(7)|ovary(1)	19	all_hematologic(180;0.162)					CAGGCCAGGCGGTCGTGGGCC	0.672000													3	5					1	1	1	1	0
ABCB6	10058	broad.mit.edu	37	2	220077176	220077176	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:220077176C>T	ENST00000265316.3	-	14	2217	c.1901G>A	c.(1900-1902)cGc>cAc	p.R634H	ABCB6_ENST00000439002.2_Missense_Mutation_p.R588H	NM_005689.2	NP_005680.1	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 6	634	ABC transporter.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	34		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAACAGCAGGCGCAAAATTGT	0.512000													23	37					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72281094	72281094	+	RNA	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:72281094C>T	ENST00000438125.1	-	0	336							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										ATTTCCCAGGCCAAATACCGC	0.428000													75	120					0	0	1	0	0
KIAA1432	57589	broad.mit.edu	37	9	5774180	5774180	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:5774180G>T	ENST00000414202.2	+	26	4397	c.4206G>T	c.(4204-4206)gaG>gaT	p.E1402D	KIAA1432_ENST00000449720.2_Missense_Mutation_p.E1286D|KIAA1432_ENST00000418622.3_Missense_Mutation_p.E1323D	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	1402						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		GGAAAGAGGAGGACACAGCCC	0.547000													32	50					1.99505e-19	2.19531e-19	1	1	0
PXDNL	137902	broad.mit.edu	37	8	52336136	52336136	+	Splice_Site	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:52336136C>A	ENST00000356297.4	-	14	1894	c.1795_splice	c.e14+1	p.T598_splice	PXDNL_ENST00000543296.1_Splice_Site_p.T598_splice	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	598					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GACACCTACCCGTGACTGTAA	0.438000													19	45					5.3912e-06	5.55592e-06	1	1	0
IGFBP1	3484	broad.mit.edu	37	7	45930298	45930298	+	Silent	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:45930298C>A	ENST00000275525.3	+	2	797	c.501C>A	c.(499-501)acC>acA	p.T167T	IGFBP1_ENST00000468955.1_Silent_p.T167T|IGFBP1_ENST00000457280.1_Silent_p.T167T	NM_000596.2	NP_000587.1	P08833	IBP1_HUMAN	insulin-like growth factor binding protein 1	167						extracellular space	insulin-like growth factor binding			large_intestine(2)|lung(4)	6						TCCATGTCACCAACATCAAAA	0.527000											OREG0018048	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	64					3.62531e-18	3.9594e-18	1	1	0
RP11-24M17.5	0	broad.mit.edu	37	15	76072999	76072999	+	RNA	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:76072999T>C	ENST00000395215.3	+	0	388																											AACAGTGAAATACACAAAGCA	0.478000													37	34					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248201969	248201969	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:248201969C>T	ENST00000366479.2	+	1	496	c.400C>T	c.(400-402)Cgt>Tgt	p.R134C	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTATCCCATCCGTATAAGCAA	0.428000													53	70					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83129489	83129489	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:83129489A>G	ENST00000329312.4	+	4	1810	c.1773A>G	c.(1771-1773)aaA>aaG	p.K591K		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	591					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						TCAATGAAAAAGGGGAAAAAG	0.418000													32	25					0	0	1	0	0
GIGYF1	64599	broad.mit.edu	37	7	100283633	100283633	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:100283633G>A	ENST00000275732.5	-	9	2227	c.1018C>T	c.(1018-1020)Cct>Tct	p.P340S	GIGYF1_ENST00000471340.2_Intron	NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	340										central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					CCTTCGGAAGGTTCCTCCTCC	0.682000													33	42					0	0	1	0	0
ZNF800	168850	broad.mit.edu	37	7	127014143	127014143	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:127014143A>G	ENST00000393313.1	-	5	1838	c.1247T>C	c.(1246-1248)gTa>gCa	p.V416A	ZNF800_ENST00000393312.1_Missense_Mutation_p.V416A|ZNF800_ENST00000265827.3_Missense_Mutation_p.V416A			Q2TB10	ZN800_HUMAN	zinc finger protein 800	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(8)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	32						TGAAGATTCTACAGAATCTGC	0.358000													28	41					0	0	1	0	0
NBPF14	25832	broad.mit.edu	37	1	148009407	148009407	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:148009407G>A	ENST00000369219.1	-	16	1916	c.1900C>T	c.(1900-1902)Ccc>Tcc	p.P634S				Q5TI25	NBPFE_HUMAN	neuroblastoma breakpoint family, member 14	634	NBPF 7.					cytoplasm				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					CTTCTGTAGGGCTGGCATGAG	0.473000													25	425					0	0	1	0	0
ATXN7L3	56970	broad.mit.edu	37	17	42272160	42272160	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:42272160C>T	ENST00000389384.4	-	10	1021	c.713G>A	c.(712-714)cGg>cAg	p.R238Q	ATXN7L3_ENST00000593073.1_5'UTR|ATXN7L3_ENST00000454077.2_Missense_Mutation_p.R245Q	NM_001098833.1	NP_001092303.1	Q14CW9	AT7L3_HUMAN	ataxin 7-like 3	238	SCA7.				histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|metal ion binding|protein binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	12		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		AAAATAAATCCGTACGGTTCG	0.577000													12	21					0	0	1	0	0
MORC4	79710	broad.mit.edu	37	X	106184836	106184836	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:106184836C>T	ENST00000355610.4	-	17	2961	c.2687G>A	c.(2686-2688)cGt>cAt	p.R896H	MORC4_ENST00000255495.7_Silent_p.T883T|MORC4_ENST00000535534.1_Silent_p.T631T	NM_001085354.2|NM_024657.4	NP_001078823.1|NP_078933.3	Q8TE76	MORC4_HUMAN	MORC family CW-type zinc finger 4	896							ATP binding|zinc ion binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	28						GACGTGGATACGTAGCCGCGT	0.498000													19	38					0	0	1	0	0
LINC00174	0	broad.mit.edu	37	7	65842378	65842378	+	RNA	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:65842378G>T	ENST00000421767.1	-	0	3354					NR_026873.1																						AGAGGCCGACGGGAACCAGTT	0.716000													4	11					0.00909568	0.00916886	1	1	0
FAM214A	56204	broad.mit.edu	37	15	52905907	52905907	+	Missense_Mutation	SNP	A	A	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:52905907A>T	ENST00000261844.7	-	3	316	c.164T>A	c.(163-165)gTa>gAa	p.V55E	FAM214A_ENST00000546305.2_Missense_Mutation_p.V62E	NM_019600.2	NP_062546.2	Q32MH5	K1370_HUMAN	family with sequence similarity 214, member A	55								p.V55E(1)									TTTGGTAGTTACTGGGTAACA	0.408000													13	20					0	0	1	0	0
FAM193B	54540	broad.mit.edu	37	5	176963600	176963600	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:176963600G>A	ENST00000443375.2	-	5	2054	c.496C>T	c.(496-498)Ccc>Tcc	p.P166S	FAM193B_ENST00000514747.1_Missense_Mutation_p.P279S|FAM193B_ENST00000508298.1_Intron|FAM193B_ENST00000329540.5_5'UTR			Q6IPW0	Q6IPW0_HUMAN	family with sequence similarity 193, member B	226										kidney(1)|large_intestine(3)	4						GGGGTGGTGGGCAGCAGGTGT	0.667000													9	12					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125072512	125072512	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:125072512T>C	ENST00000522917.1	+	23	3172	c.2966T>C	c.(2965-2967)cTg>cCg	p.L989P	FER1L6-AS2_ENST00000601180.1_RNA|FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.L989P	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	989						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CGGCCGGTGCTGAGCAAATAC	0.587000													118	54					0	0	1	0	0
RANGAP1	5905	broad.mit.edu	37	22	41654017	41654017	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:41654017G>A	ENST00000455915.2	-	6	2178	c.709C>T	c.(709-711)Ctg>Ttg	p.L237L	RANGAP1_ENST00000356244.3_Silent_p.L237L|RANGAP1_ENST00000405486.1_Silent_p.L237L|RANGAP1_ENST00000407260.4_Silent_p.L182L			P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	237					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ACCCGCAGCAGGGGGTTGACA	0.627000													35	36					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59221723	59221723	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:59221723A>G	ENST00000262717.4	+	12	2599	c.2201A>G	c.(2200-2202)gAc>gGc	p.D734G	CDH20_ENST00000538374.1_Missense_Mutation_p.D734G|CDH20_ENST00000536675.2_Missense_Mutation_p.D734G			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	734					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				TACGAGGCCGACATGGACCTG	0.647000													10	12					0	0	1	0	0
ACTR1A	10121	broad.mit.edu	37	10	104241927	104241927	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:104241927A>G	ENST00000369905.4	-	8	819	c.756T>C	c.(754-756)ggT>ggC	p.G252G	ACTR1A_ENST00000487599.1_Silent_p.G252G|ACTR1A_ENST00000446605.2_Silent_p.G205G|ACTR1A_ENST00000470322.1_5'UTR|ACTR1A_ENST00000545684.1_Silent_p.G178G	NM_005736.3	NP_005727.1	P61163	ACTZ_HUMAN	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	252					G2/M transition of mitotic cell cycle|vesicle-mediated transport	centrosome|cytosol|dynactin complex	ATP binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	13		Colorectal(252;0.122)		Epithelial(162;5.34e-09)|all cancers(201;1.43e-07)|BRCA - Breast invasive adenocarcinoma(275;0.222)		ATCGGGAAGGACCAATCTGCA	0.572000													51	150					0	0	1	0	0
PXT1	222659	broad.mit.edu	37	6	36359628	36359628	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:36359628A>G	ENST00000454782.2	-	5	807	c.324T>C	c.(322-324)gaT>gaC	p.D108D	RP1-50J22.4_ENST00000411643.1_RNA	NM_152990.3	NP_694535.2	Q8NFP0	PXT1_HUMAN	peroxisomal, testis specific 1	25						peroxisome											GATCTAGTGCATCTCTGCCAT	0.323000													37	93					0	0	1	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43474152	43474152	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:43474152C>T	ENST00000532038.1	-	11	1425	c.1290G>A	c.(1288-1290)gcG>gcA	p.A430A	ARHGAP27_ENST00000455881.1_Silent_p.A311A|ARHGAP27_ENST00000528384.1_Silent_p.A284A|ARHGAP27_ENST00000428638.1_Silent_p.A652A|ARHGAP27_ENST00000442348.1_Silent_p.A625A|ARHGAP27_ENST00000532891.2_Silent_p.A630A|ARHGAP27_ENST00000376922.2_Silent_p.A311A			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	652	WW 3.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					CCAGGGCGGGCGCGGCTGCCG	0.716000													9	25					0	0	1	0	0
LGALS9	3965	broad.mit.edu	37	17	25976006	25976006	+	Nonstop_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:25976006T>C	ENST00000395473.2	+	11	2534	c.1066T>C	c.(1066-1068)Tag>Cag	p.*356Q	LGALS9_ENST00000413914.2_3'UTR|LGALS9_ENST00000313648.6_3'UTR|LGALS9_ENST00000310394.5_Nonstop_Mutation_p.*312Q|LGALS9_ENST00000302228.5_Nonstop_Mutation_p.*324Q	NM_009587.2	NP_033665.1	O00182	LEG9_HUMAN	lectin, galactoside-binding, soluble, 9	0					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity			endometrium(3)|large_intestine(2)|lung(12)|skin(1)	18	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		TGTGCAGACATAGGCGGCTTC	0.627000													72	121					0	0	1	0	0
IPO7	10527	broad.mit.edu	37	11	9452491	9452491	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:9452491G>A	ENST00000379719.3	+	16	1964	c.1822G>A	c.(1822-1824)Gct>Act	p.A608T	CTD-2371O3.2_ENST00000531111.1_RNA	NM_006391.2	NP_006382.1	O95373	IPO7_HUMAN	importin 7	608					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		AGCAGTTACTGCTATGGGAAT	0.363000													25	27					0	0	1	0	0
MAPK8IP1	9479	broad.mit.edu	37	11	45924624	45924624	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:45924624C>T	ENST00000395629.2	+	5	1606	c.1276C>T	c.(1276-1278)Cgg>Tgg	p.R426W	MAPK8IP1_ENST00000241014.2_Missense_Mutation_p.R436W			Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting protein 1	436					vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)	24				GBM - Glioblastoma multiforme(35;0.231)		GGAGGCCCCGCGGCCCCAGCC	0.602000													18	32					0	0	1	0	0
RAB11A	8766	broad.mit.edu	37	15	66170108	66170108	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:66170108G>A	ENST00000261890.2	+	3	373	c.245G>A	c.(244-246)cGt>cAt	p.R82H	RAB11A_ENST00000435304.2_Missense_Mutation_p.R82H|RAB11A_ENST00000564910.1_Intron|RAB11A_ENST00000565075.1_Missense_Mutation_p.R82H|RAB11A_ENST00000569896.1_Missense_Mutation_p.R82H	NM_001206836.1|NM_004663.4	NP_001193765.1|NP_004654.1	P62491	RB11A_HUMAN	RAB11A, member RAS oncogene family	82					cell cycle|cytokinesis|neuron projection development|plasma membrane to endosome transport|protein localization in plasma membrane|small GTPase mediated signal transduction|vesicle-mediated transport	cleavage furrow|plasma membrane|recycling endosome membrane|trans-Golgi network	GTP binding|GTPase activity|syntaxin binding			kidney(1)|large_intestine(2)|lung(1)|prostate(1)	5						AGATATTATCGTGGAGCTGTA	0.358000													17	48					0	0	1	0	0
ILDR2	387597	broad.mit.edu	37	1	166890248	166890248	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:166890248G>A	ENST00000271417.3	-	9	1635	c.1580C>T	c.(1579-1581)tCg>tTg	p.S527L	ILDR2_ENST00000528703.1_Missense_Mutation_p.S468L|ILDR2_ENST00000469934.2_Intron|ILDR2_ENST00000525740.1_Missense_Mutation_p.S400L|ILDR2_ENST00000529071.1_Missense_Mutation_p.S508L|ILDR2_ENST00000529387.1_Intron|ILDR2_ENST00000526687.1_Missense_Mutation_p.S419L	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	527						integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						GCCCAGGTACGAGTGGTCGTA	0.776000													3	7					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139906583	139906583	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:139906583C>T	ENST00000297183.6	+	27	5135	c.5011C>T	c.(5011-5013)Cca>Tca	p.P1671S	ANKHD1_ENST00000360839.2_Missense_Mutation_p.P1671S|ANKHD1_ENST00000544120.1_Missense_Mutation_p.P54S|ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.P1671S	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTAAGCTCTCCAAACATAAA	0.388000													15	77					0	0	1	0	0
ZC3H18	124245	broad.mit.edu	37	16	88643557	88643557	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:88643557G>A	ENST00000301011.5	+	2	226	c.26G>A	c.(25-27)cGg>cAg	p.R9Q	ZC3H18_ENST00000452588.2_Missense_Mutation_p.R9Q	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	9						nucleus	nucleic acid binding|zinc ion binding	p.R9L(1)		endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		AGCCCTGAACGGGATCCTCAC	0.547000													25	44					0	0	1	0	0
ATP11C	286410	broad.mit.edu	37	X	138882232	138882232	+	Nonsense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:138882232C>A	ENST00000370557.1	-	8	1724	c.697G>T	c.(697-699)Gag>Tag	p.E233*	ATP11C_ENST00000359686.2_Nonsense_Mutation_p.E236*|ATP11C_ENST00000361648.2_Nonsense_Mutation_p.E236*|ATP11C_ENST00000370543.1_Nonsense_Mutation_p.E236*|ATP11C_ENST00000327569.3_Nonsense_Mutation_p.E236*			Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C	236					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					GCAACAGCCTCAAGACTATTA	0.368000													35	68					2.40579e-17	2.60801e-17	1	1	0
NRAP	4892	broad.mit.edu	37	10	115410306	115410306	+	Splice_Site	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:115410306T>C	ENST00000369358.4	-	8	920		c.e8-2		NRAP_ENST00000369360.3_Splice_Site|NRAP_ENST00000359988.3_Splice_Site|NRAP_ENST00000360478.3_Splice_Site			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein							fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		GTATCTCACCTGAAATGAAAA	0.458000													19	41					0	0	1	0	0
JMJD4	65094	broad.mit.edu	37	1	227922791	227922791	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:227922791T>C	ENST00000366758.3	-	1	321	c.322A>G	c.(322-324)Acg>Gcg	p.T108A	SNAP47_ENST00000366759.4_5'UTR|SNAP47_ENST00000315781.5_5'UTR|JMJD4_ENST00000438896.2_Missense_Mutation_p.T108A|SNAP47_ENST00000366760.1_Intron	NM_023007.2	NP_075383.2	Q9H9V9	JMJD4_HUMAN	jumonji domain containing 4	108										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)	9		Prostate(94;0.0885)				CAGCCCTGCGTGAAGGCGCTG	0.721000													4	16					0	0	1	0	0
MFI2	4241	broad.mit.edu	37	3	196733483	196733483	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:196733483G>A	ENST00000296350.5	-	14	1988	c.1875C>T	c.(1873-1875)caC>caT	p.H625H		NM_005929.5	NP_005920.2	P08582	TRFM_HUMAN	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	625	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(1)	20	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		CCATCACGGCGTGGGGTGGTA	0.627000													17	39					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10364532	10364532	+	Missense_Mutation	SNP	C	C	T	rs146807975		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:10364532C>T	ENST00000377093.4	+	21	3442	c.3289C>T	c.(3289-3291)Cgt>Tgt	p.R1097C	KIF1B_ENST00000377083.1_Missense_Mutation_p.R1097C|KIF1B_ENST00000377086.1_Intron|KIF1B_ENST00000263934.6_Intron|KIF1B_ENST00000377081.1_Intron	NM_183416.3	NP_904325.2	O60333	KIF1B_HUMAN	kinesin family member 1B	0					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		TCATCAACACCGTCAGTCTTA	0.507000													39	59					0	0	1	0	0
SLC17A5	26503	broad.mit.edu	37	6	74363524	74363524	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:74363524G>A	ENST00000355773.5	-	1	354	c.86C>T	c.(85-87)gCc>gTc	p.A29V	SLC17A5_ENST00000393019.3_Missense_Mutation_p.A29V	NM_012434.4	NP_036566.1	Q9NRA2	S17A5_HUMAN	solute carrier family 17 (acidic sugar transporter), member 5	29					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						ACCGGCTTCGGCCCGTGGGGC	0.726000													13	4					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46815488	46815488	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:46815488C>T	ENST00000339613.2	+	7	928	c.673C>T	c.(673-675)Ctg>Ttg	p.L225L	HIF3A_ENST00000300862.3_Silent_p.L279L|HIF3A_ENST00000244303.6_Silent_p.L212L|HIF3A_ENST00000525854.1_3'UTR|HIF3A_ENST00000420102.2_Silent_p.L230L|HIF3A_ENST00000600383.1_Silent_p.L212L|HIF3A_ENST00000472815.1_Silent_p.L212L|HIF3A_ENST00000377670.4_Silent_p.L281L			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		CATCCACGCGCTGGACTCCGA	0.612000													58	86					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1581004	1581004	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:1581004G>A	ENST00000421627.2	+	5	1496	c.1362G>A	c.(1360-1362)gcG>gcA	p.A454A		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	533					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding	p.A476A(1)		breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TGAGCGAGGCGGAGATCAATG	0.572000													27	23					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37740148	37740148	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:37740148C>T	ENST00000539465.1	+	15	2216	c.1623C>T	c.(1621-1623)gaC>gaT	p.D541D	FRMPD1_ENST00000377765.3_Silent_p.D541D|FRMPD1_ENST00000536622.1_Silent_p.D363D|FRMPD1_ENST00000541302.1_Silent_p.D410D|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	541						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		CTCTCTCTGACAGGCGCCTGG	0.587000													49	88					0	0	1	0	0
APOA5	0	broad.mit.edu	37	11	116661100	116661100	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:116661100C>T	ENST00000542499.1	-	4	917	c.845G>A	c.(844-846)cGc>cAc	p.R282H	APOA5_ENST00000227665.4_Missense_Mutation_p.R282H	NM_001166598.1|NM_052968.4	NP_001160070.1|NP_443200.2	Q6Q788	APOA5_HUMAN	apolipoprotein A-V	282					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|urinary_tract(1)	14	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		AAGTCGCTGGCGCACCTCCTC	0.652000													50	75					0	0	1	0	0
WNT5B	81029	broad.mit.edu	37	12	1748922	1748922	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:1748922G>A	ENST00000397196.2	+	4	633	c.401G>A	c.(400-402)cGc>cAc	p.R134H	WNT5B_ENST00000310594.3_Missense_Mutation_p.R134H|WNT5B_ENST00000542408.1_Intron|WNT5B_ENST00000537031.1_Missense_Mutation_p.R134H	NM_032642.2	NP_116031.1	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family, member 5B	134				R -> S (in Ref. 1; AAG38659).	angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			CGGGCCTGCCGCGAGGGCGAG	0.731000													4	15					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50255979	50255979	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:50255979A>G	ENST00000338821.5	-	15	1835	c.1571T>C	c.(1570-1572)aTg>aCg	p.M524T	ATP9A_ENST00000402822.1_Missense_Mutation_p.M403T|ATP9A_ENST00000311637.5_Missense_Mutation_p.M388T	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	524					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						CCTCAGCTGCATGGAAGACTG	0.552000											OREG0026043	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	100					0	0	1	0	0
MLK4	0	broad.mit.edu	37	1	233515338	233515338	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:233515338A>G	ENST00000366624.3	+	9	2847	c.2586A>G	c.(2584-2586)tcA>tcG	p.S862S	MLK4_ENST00000366622.1_Silent_p.S308S	NM_032435.2	NP_115811.2																					GTAGTGTATCAAGAAACTTGC	0.498000													7	72					0	0	1	0	0
MTUS1	57509	broad.mit.edu	37	8	17611442	17611442	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:17611442G>A	ENST00000381869.3	-	2	2348	c.1875C>T	c.(1873-1875)tgC>tgT	p.C625C	MTUS1_ENST00000262102.6_Silent_p.C625C|MTUS1_ENST00000519263.1_Silent_p.C625C|MTUS1_ENST00000381862.3_Silent_p.C625C	NM_001001925.2	NP_001001925.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	625						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		ACCCGGTCTCGCATGCTGAGT	0.433000													79	219					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42333926	42333926	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:42333926T>C	ENST00000217026.4	+	9	1560	c.1433T>C	c.(1432-1434)gTg>gCg	p.V478A	MYBL2_ENST00000396863.4_Missense_Mutation_p.V454A	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	478						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TCCACCCCAGTGTGCAGCCAG	0.557000													28	67					0	0	1	0	0
NAT16	375607	broad.mit.edu	37	7	100816662	100816662	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:100816662T>C	ENST00000300303.2	-	3	690	c.452A>G	c.(451-453)cAc>cGc	p.H151R	NAT16_ENST00000455377.1_Missense_Mutation_p.H151R	NM_198571.2	NP_940973.2	Q8N8M0	CG052_HUMAN	N-acetyltransferase 16 (GCN5-related, putative)	151	N-acetyltransferase.						N-acetyltransferase activity										GACCCCCGGGTGCTGTCTCTT	0.692000													19	27					0	0	1	0	0
GPR61	0	broad.mit.edu	37	1	110086356	110086356	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:110086356G>T	ENST00000527748.1	+	2	1395	c.712G>T	c.(712-714)Gct>Tct	p.A238S	RP5-1160K1.8_ENST00000526411.1_RNA	NM_031936.4	NP_114142.3	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	238						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(9)|stomach(1)|urinary_tract(1)	23		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		GGCCCGCGTGGCTGCCATGCA	0.617000													98	159					1.94071e-40	2.1933e-40	1	1	0
OR1L1	26737	broad.mit.edu	37	9	125424190	125424190	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:125424190C>T	ENST00000373686.1	+	1	346	c.346C>T	c.(346-348)Ctg>Ttg	p.L116L				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						TCTAAGCATCCTGTCTTTTGT	0.453000													44	75					0	0	1	0	0
ACBD5	91452	broad.mit.edu	37	10	27494154	27494154	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:27494154C>T	ENST00000396271.3	-	11	1554	c.1428G>A	c.(1426-1428)ttG>ttA	p.L476L	ACBD5_ENST00000375905.4_Silent_p.L441L|ACBD5_ENST00000375901.1_Silent_p.L367L|ACBD5_ENST00000375897.3_Silent_p.L299L|ACBD5_ENST00000375888.1_Silent_p.L485L|ACBD5_ENST00000476758.1_5'UTR	NM_145698.3	NP_663736.2	Q5T8D3	ACBD5_HUMAN	acyl-CoA binding domain containing 5	485					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						GAGCAGTCTGCAATGTTGATG	0.313000													34	63					0	0	1	0	0
OR4K13	390433	broad.mit.edu	37	14	20502395	20502395	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:20502395C>A	ENST00000315693.2	-	1	524	c.523G>T	c.(523-525)Gac>Tac	p.D175Y		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AAAAAGCTGTCTATAACATTG	0.473000													38	58					1.30998e-17	1.42185e-17	1	1	0
ATAD2	29028	broad.mit.edu	37	8	124382144	124382144	+	Missense_Mutation	SNP	T	T	C	rs150184958		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:124382144T>C	ENST00000287394.5	-	7	955	c.848A>G	c.(847-849)gAa>gGa	p.E283G	ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	283	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			tccatcttcttcatcttcatc	0.368000													26	17					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24884026	24884026	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:24884026C>T	ENST00000382554.3	+	9	3389	c.3071C>T	c.(3070-3072)gCg>gTg	p.A1024V		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1024					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TCTTCGCTGGCGTCAGTGTTC	0.627000													28	30					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219883883	219883883	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:219883883G>A	ENST00000341552.5	-	21	3575	c.3492C>T	c.(3490-3492)ccC>ccT	p.P1164P	CCDC108_ENST00000453220.1_Silent_p.P1164P|CCDC108_ENST00000441968.1_Silent_p.P1164P	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1164						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGTGAGGACGGGGGGGATCT	0.612000													39	61					0	0	1	0	0
FER	2241	broad.mit.edu	37	5	108203563	108203563	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:108203563C>T	ENST00000281092.4	+	6	961	c.577C>T	c.(577-579)Cag>Tag	p.Q193*	FER_ENST00000438717.2_Nonsense_Mutation_p.Q18*|FER_ENST00000536402.1_Nonsense_Mutation_p.Q193*	NM_005246.2	NP_005237.2	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	193	Important for interaction with membranes containing phosphoinositides.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			NS(2)|biliary_tract(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	32		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		GAAAGGGGCACAGCTCCATCA	0.403000													17	41					0	0	1	0	0
PELI3	246330	broad.mit.edu	37	11	66241352	66241352	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:66241352T>C	ENST00000349459.6	+	6	1008	c.724T>C	c.(724-726)Tac>Cac	p.Y242H	PELI3_ENST00000524466.1_Missense_Mutation_p.Y266H|PELI3_ENST00000531856.1_Intron|CTD-3074O7.5_ENST00000527092.1_RNA|PELI3_ENST00000320740.7_Missense_Mutation_p.Y266H	NM_001098510.1	NP_001091980.1	Q8N2H9	PELI3_HUMAN	pellino E3 ubiquitin protein ligase family member 3	266						cytosol	protein binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(1)	15						TGGGAATGTGTACACATTGCG	0.652000													9	110					0	0	1	0	0
USP20	0	broad.mit.edu	37	9	132630693	132630693	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:132630693C>A	ENST00000315480.4	+	11	1258	c.1100C>A	c.(1099-1101)cCg>cAg	p.P367Q	USP20_ENST00000372429.3_Missense_Mutation_p.P367Q|USP20_ENST00000358355.1_Missense_Mutation_p.P367Q			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	367					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				GCCCAGCCCCCGTCACCACGG	0.677000													33	62					4.74835e-14	5.09084e-14	1	1	0
OPRK1	4986	broad.mit.edu	37	8	54163550	54163550	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:54163550G>A	ENST00000265572.3	-	2	345	c.48C>T	c.(46-48)tgC>tgT	p.C16C	OPRK1_ENST00000520287.1_Silent_p.C16C	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	16					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	CGCTCGGGGCGCAGGTAGGGC	0.741000													17	33					0	0	1	0	0
SMO	6608	broad.mit.edu	37	7	128843292	128843292	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:128843292G>T	ENST00000249373.3	+	2	679	c.399G>T	c.(397-399)aaG>aaT	p.K133N		NM_005631.4	NP_005622.1	Q99835	SMO_HUMAN	smoothened, frizzled family receptor	133	FZ.				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			biliary_tract(1)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(14)|liver(1)|lung(11)|pancreas(2)|prostate(1)|skin(20)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						ACATGCCCAAGTGTGAGAATG	0.672000			Mis		skin basal cell								3	3					0.115264	0.11566	1	1	0
PFN2	5217	broad.mit.edu	37	3	149684300	149684300	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:149684300T>C	ENST00000239940.7	-	3	651	c.399A>G	c.(397-399)aaA>aaG	p.K133K	PFN2_ENST00000481767.1_Intron|PFN2_ENST00000489155.1_Silent_p.K84K|PFN2_ENST00000490975.1_Silent_p.K118K|PFN2_ENST00000497148.1_Silent_p.K84K|PFN2_ENST00000452853.2_Intron|PFN2_ENST00000423691.2_Intron|PFN2_ENST00000475518.1_Silent_p.K84K|PFN2_ENST00000481275.1_Silent_p.K84K|PFN2_ENST00000494827.1_Intron|PFN2_ENST00000498307.1_Silent_p.K84K			P35080	PROF2_HUMAN	profilin 2	133					actin cytoskeleton organization|regulation of actin polymerization or depolymerization	actin cytoskeleton|cytoplasm	actin binding|phosphatidylinositol-4,5-bisphosphate binding			large_intestine(1)|lung(4)|ovary(1)|prostate(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CTCTCAAGTATTTTGCCATTG	0.393000													269	327					0	0	1	0	0
PROCA1	147011	broad.mit.edu	37	17	27031790	27031790	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:27031790C>T	ENST00000301039.2	-	2	356	c.163G>A	c.(163-165)Gcc>Acc	p.A55T	PROCA1_ENST00000581289.1_Intron|PROCA1_ENST00000579650.1_5'UTR|PROCA1_ENST00000439862.3_Missense_Mutation_p.A57T	NM_152465.1	NP_689678.1	Q8NCQ7	PRCA1_HUMAN	protein interacting with cyclin A1	83					lipid catabolic process		calcium ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(4)|ovary(1)|urinary_tract(1)	16	Lung NSC(42;0.00431)					CAGTCAGAGGCGAAAGGGTAG	0.592000													31	44					0	0	1	0	0
MINK1	50488	broad.mit.edu	37	17	4798393	4798393	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:4798393C>T	ENST00000355280.6	+	25	3137	c.2941C>T	c.(2941-2943)Cgg>Tgg	p.R981W	MINK1_ENST00000453408.3_Missense_Mutation_p.R961W|MINK1_ENST00000347992.7_Missense_Mutation_p.R952W	NM_001024937.3|NM_015716.4|NM_153827.4	NP_001020108.1|NP_056531.1|NP_722549.2	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1	981	Mediates interaction with RAP2A.				JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						AGAGGGCACTCGGCTCGACCA	0.597000													21	36					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164712126	164712126	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:164712126T>C	ENST00000264382.3	-	41	4822	c.4760A>G	c.(4759-4761)tAc>tGc	p.Y1587C		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1587	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CAATAAGGTGTATCTAATATT	0.348000										HNSCC(35;0.089)			30	27					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134941910	134941910	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:134941910A>G	ENST00000607359.1	+	16	2735	c.2735A>G	c.(2734-2736)tAc>tGc	p.Y912C	GPR123_ENST00000392606.2_Missense_Mutation_p.Y96C|GPR123_ENST00000392607.3_Missense_Mutation_p.Y193C			Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	193						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		ACCTGTGTGTACTTCCTGGGC	0.701000													20	22					0	0	1	0	0
SEMA6A	57556	broad.mit.edu	37	5	115783143	115783143	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:115783143C>T	ENST00000343348.6	-	19	3046	c.2259G>A	c.(2257-2259)acG>acA	p.T753T	SEMA6A_ENST00000513137.1_Silent_p.T180T|SEMA6A_ENST00000282394.6_Silent_p.T230T|SEMA6A_ENST00000510263.1_Silent_p.T753T|SEMA6A_ENST00000503865.1_Silent_p.T132T|SEMA6A_ENST00000257414.8_Silent_p.T770T	NM_020796.3	NP_065847.1	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	753					apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		TGGGGAGGGCCGTCAGGTCCA	0.632000													172	144					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128410948	128410948	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:128410948T>C	ENST00000368227.3	-	8	1718	c.1352A>G	c.(1351-1353)cAg>cGg	p.Q451R	PTPRK_ENST00000368215.3_Missense_Mutation_p.Q451R|PTPRK_ENST00000368207.3_Missense_Mutation_p.Q451R|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368210.3_Missense_Mutation_p.Q451R|PTPRK_ENST00000368213.5_Missense_Mutation_p.Q451R|PTPRK_ENST00000532331.1_Missense_Mutation_p.Q451R|PTPRK_ENST00000368226.4_Missense_Mutation_p.Q451R			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	451	Fibronectin type-III 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		CACAACATGCTGAGGGGCTTT	0.468000													91	48					0	0	1	0	0
GNL1	2794	broad.mit.edu	37	6	30521243	30521243	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:30521243G>A	ENST00000376621.3	-	6	1662	c.692C>T	c.(691-693)cCg>cTg	p.P231L		NM_005275.3	NP_005266.2	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	231					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			cervix(2)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	25						AAGAGCTGGCGGGGCCAGATC	0.542000													104	73					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23887559	23887559	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:23887559C>T	ENST00000355349.3	-	30	4191	c.4029G>A	c.(4027-4029)ctG>ctA	p.L1343L		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1343					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		ACTGCTCCCGCAGCAGGTCGC	0.657000													40	60					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72822572	72822572	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:72822572C>T	ENST00000268489.5	-	10	10275	c.9603G>A	c.(9601-9603)caG>caA	p.Q3201Q	ZFHX3_ENST00000397992.5_Silent_p.Q2287Q	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3201	Poly-Gln.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				gttgctgctgctgctgctgct	0.652000													89	117					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26116151	26116151	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:26116151A>G	ENST00000381655.2	+	9	888	c.746A>G	c.(745-747)gAc>gGc	p.D249G	ATP8A2_ENST00000255283.8_Missense_Mutation_p.D209G	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	209					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		CACCTCTATGACTTCACTGGA	0.393000													28	33					0	0	1	0	0
FKRP	79147	broad.mit.edu	37	19	47260141	47260141	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:47260141C>T	ENST00000318584.5	+	4	1731	c.1434C>T	c.(1432-1434)atC>atT	p.I478I	FKRP_ENST00000391909.3_Silent_p.I478I|FKRP_ENST00000600646.1_Intron	NM_001039885.2|NM_024301.4	NP_001034974.1|NP_077277.1	Q9H9S5	FKRP_HUMAN	fukutin related protein	478						extracellular space|Golgi apparatus|rough endoplasmic reticulum|sarcolemma	transferase activity			NS(1)|large_intestine(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7		all_epithelial(76;5.08e-05)|Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000541)|all cancers(93;0.00128)|Epithelial(262;0.0207)|GBM - Glioblastoma multiforme(486;0.0336)		CCGGGGTCATCGAGAACCCCC	0.637000													9	11					0	0	1	0	0
NUDT14	256281	broad.mit.edu	37	14	105643364	105643364	+	Splice_Site	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:105643364G>A	ENST00000392568.2	-	3	219	c.125_splice	c.e3-1	p.S42_splice	RP11-44N21.4_ENST00000548203.1_RNA	NM_177533.4	NP_803877.2	O95848	NUD14_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 14	42	Nudix hydrolase.					cytoplasm	metal ion binding|protein binding|UDP-sugar diphosphatase activity			cervix(2)|endometrium(1)|lung(3)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	14		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		GAACGGTCACGCTGTGTACGG	0.632000										HNSCC(42;0.11)			16	18					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29633900	29633900	+	Missense_Mutation	SNP	A	A	G	rs60081496	by1000genomes	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:29633900A>G	ENST00000278882.3	+	9	919	c.539A>G	c.(538-540)gAa>gGa	p.E180G	FRG1B_ENST00000358464.4_Missense_Mutation_p.E180G														p.E180G(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAAACAAGAGAACCAAATTGA	0.264000													6	38					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68215288	68215288	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:68215288T>C	ENST00000347230.4	-	42	7623	c.7485A>G	c.(7483-7485)tcA>tcG	p.S2495S		NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	2495					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CTGTGGCCCGTGAGTGTTCTT	0.562000													36	54					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105965735	105965735	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:105965735G>T	ENST00000357060.3	-	7	1064	c.949C>A	c.(949-951)Ctg>Atg	p.L317M	WDR96_ENST00000369719.1_Missense_Mutation_p.L248M|WDR96_ENST00000369720.1_Missense_Mutation_p.L248M|WDR96_ENST00000278064.2_Missense_Mutation_p.L248M|WDR96_ENST00000428666.1_Missense_Mutation_p.L318M	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	317										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						CCAGAAGCCAGCACGCCCTCC	0.328000													27	10					2.80507e-11	2.98188e-11	1	1	0
GRB7	2886	broad.mit.edu	37	17	37899524	37899524	+	Silent	SNP	C	C	T	rs145171655		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:37899524C>T	ENST00000309156.4	+	5	812	c.555C>T	c.(553-555)ttC>ttT	p.F185F	GRB7_ENST00000445327.2_Silent_p.F208F|GRB7_ENST00000578702.1_3'UTR|GRB7_ENST00000394209.2_Silent_p.F185F|GRB7_ENST00000394211.3_Silent_p.F185F|GRB7_ENST00000309185.3_Silent_p.F185F|GRB7_ENST00000394204.1_Silent_p.F185F	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	185	Ras-associating.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GGAAAAACTTCGCCAAGTACG	0.617000													50	51					0	0	1	0	0
RP11-472B18.1	0	broad.mit.edu	37	4	39482626	39482626	+	RNA	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:39482626G>A	ENST00000513652.1	+	0	633																											CATTTTAATCGTGATGGATTC	0.468000													26	22					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179575969	179575969	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:179575969C>T	ENST00000589042.1	-	97	28218	c.27994G>A	c.(27994-27996)Gtg>Atg	p.V9332M	TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V8088M|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.V9015M|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9015	Ig-like 76.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACCAAGACACGGAGATAGGT	0.393000													63	124					0	0	1	0	0
MAP3K5	4217	broad.mit.edu	37	6	136990430	136990430	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:136990430G>C	ENST00000359015.4	-	8	1717	c.1357C>G	c.(1357-1359)Cgg>Ggg	p.R453G		NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	453					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		CCAACTTTCCGGAGCTCAAAG	0.393000													41	105					0	0	1	0	0
MSL3P1	0	broad.mit.edu	37	2	234775123	234775123	+	RNA	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:234775123C>T	ENST00000438684.1	-	0	991					NR_024322.1																						CCCTTCCTGGCTAGGAGTCAG	0.502000													25	57					0	0	1	0	0
MRI1	84245	broad.mit.edu	37	19	13879657	13879657	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:13879657C>T	ENST00000319545.8	+	5	660	c.603C>T	c.(601-603)gaC>gaT	p.D201D	MRI1_ENST00000040663.6_Silent_p.D248D	NM_032285.2	NP_115661.1	Q9BV20	MTNA_HUMAN	methylthioribose-1-phosphate isomerase 1	248					L-methionine salvage from methylthioadenosine	cell projection|cytoplasm|nucleus	identical protein binding|S-methyl-5-thioribose-1-phosphate isomerase activity			breast(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	6						TGGGAGCTGACCGCGTGGTTG	0.647000													10	29					0	0	1	0	0
LMCD1	29995	broad.mit.edu	37	3	8579029	8579029	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:8579029A>G	ENST00000157600.3	+	3	522	c.290A>G	c.(289-291)aAc>aGc	p.N97S	LMCD1_ENST00000397386.3_Intron|LMCD1_ENST00000535732.1_Missense_Mutation_p.N97S|LMCD1_ENST00000454244.1_Missense_Mutation_p.N24S|LMCD1-AS1_ENST00000439407.1_RNA	NM_014583.2	NP_055398.1	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	97					positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)	16				OV - Ovarian serous cystadenocarcinoma(96;0.124)		TACAAGAGGAACCGGATGATC	0.537000													110	128					0	0	1	0	0
TSPAN9	10867	broad.mit.edu	37	12	3392257	3392257	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:3392257G>A	ENST00000011898.5	+	9	856	c.695G>A	c.(694-696)cGg>cAg	p.R232Q	TSPAN9_ENST00000537971.1_Missense_Mutation_p.R232Q	NM_006675.4	NP_006666.1	O75954	TSN9_HUMAN	tetraspanin 9	232						integral to plasma membrane|membrane fraction				endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00153)|COAD - Colon adenocarcinoma(12;0.0831)			CACATCCACCGGACTGGTAAG	0.637000													4	106					0	0	1	0	0
COLGALT1	79709	broad.mit.edu	37	19	17691986	17691986	+	Splice_Site	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:17691986G>A	ENST00000252599.4	+	12	1722	c.1601_splice	c.e12-1	p.V534_splice		NM_024656.2	NP_078932.2			collagen beta(1-O)galactosyltransferase 1																		CTCCCCCCAGGTCCGAGTACA	0.592000													172	270					0	0	1	0	0
OLFM1	10439	broad.mit.edu	37	9	138011985	138011985	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:138011985C>T	ENST00000252854.4	+	6	1552	c.1365C>T	c.(1363-1365)aaC>aaT	p.N455N	OLFM1_ENST00000371793.3_Silent_p.N473N|OLFM1_ENST00000371796.3_Silent_p.N446N	NM_014279.4	NP_055094.1	Q99784	NOE1_HUMAN	olfactomedin 1	473	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)	21		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		TCCTCTACAACGTGACCCTCT	0.572000													23	43					0	0	1	0	0
MCM2	4171	broad.mit.edu	37	3	127335929	127335929	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:127335929C>T	ENST00000265056.7	+	10	1985	c.1741C>T	c.(1741-1743)Cga>Tga	p.R581*		NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	581	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						TCTGGCTGACCGAGGAGTGTG	0.647000													82	98					0	0	1	0	0
TTC22	55001	broad.mit.edu	37	1	55266305	55266305	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:55266305C>T	ENST00000371276.4	-	1	635	c.532G>A	c.(532-534)Gcg>Acg	p.A178T	TTC22_ENST00000371274.4_Missense_Mutation_p.A178T	NM_001114108.1	NP_001107580.1	Q5TAA0	TTC22_HUMAN	tetratricopeptide repeat domain 22	178							binding			kidney(1)|large_intestine(1)|lung(7)|skin(1)	10						TCGTAGAGCGCGATGCCTGCC	0.701000													9	7					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2160364	2160364	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:2160364G>A	ENST00000262304.4	-	15	5012	c.4804C>T	c.(4804-4806)Cgc>Tgc	p.R1602C	PKD1_ENST00000423118.1_Missense_Mutation_p.R1602C	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	1602	PKD 11.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						CCCACGGAGCGGAAGGTGTAA	0.612000													43	54					0	0	1	0	0
XRCC1	7515	broad.mit.edu	37	19	44057626	44057626	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:44057626C>A	ENST00000262887.5	-	6	1075	c.528G>T	c.(526-528)aaG>aaT	p.K176N	XRCC1_ENST00000543982.1_Missense_Mutation_p.K145N|L34079.3_ENST00000597119.1_RNA			P18887	XRCC1_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 1	176					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Prostate(69;0.0153)				CATCCTCCTCCTTCACACGGA	0.597000								Other BER factors					42	55					3.54561e-26	3.96114e-26	1	1	0
MMRN1	22915	broad.mit.edu	37	4	90816607	90816607	+	Missense_Mutation	SNP	C	C	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:90816607C>G	ENST00000394980.1	+	2	804	c.485C>G	c.(484-486)aCt>aGt	p.T162S	MMRN1_ENST00000394981.1_Missense_Mutation_p.T128S|MMRN1_ENST00000264790.2_Missense_Mutation_p.T162S			Q13201	MMRN1_HUMAN	multimerin 1	162					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		GTtggaggcactggaggcatt	0.507000													35	39					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43933378	43933378	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:43933378C>T	ENST00000537548.1	-	4	377	c.133G>A	c.(133-135)Gtg>Atg	p.V45M	MATN4_ENST00000372751.4_Intron|MATN4_ENST00000372754.1_Missense_Mutation_p.V45M|MATN4_ENST00000360607.5_Missense_Mutation_p.V45M|MATN4_ENST00000372756.1_Missense_Mutation_p.V45M|MATN4_ENST00000353917.5_Missense_Mutation_p.V45M|MATN4_ENST00000372753.1_Intron|MATN4_ENST00000342716.4_Missense_Mutation_p.V45M			O95460	MATN4_HUMAN	matrilin 4	45	VWFA 1.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				AAAGGGCGCACGCTGCGGGAG	0.632000													19	41					0	0	1	0	0
NUP37	79023	broad.mit.edu	37	12	102468812	102468812	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:102468812G>A	ENST00000552283.1	-	9	973	c.834C>T	c.(832-834)agC>agT	p.S278S	NUP37_ENST00000251074.1_Silent_p.S278S			Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	278					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			endometrium(3)|large_intestine(3)|lung(10)|ovary(1)	17						TTTGAAACTGGCTTGCCATTT	0.343000													22	24					0	0	1	0	0
ALDH1B1	219	broad.mit.edu	37	9	38395909	38395909	+	Missense_Mutation	SNP	C	C	T	rs144062423	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:38395909C>T	ENST00000377698.3	+	2	317	c.164C>T	c.(163-165)cCg>cTg	p.P55L		NM_000692.4	NP_000683.3	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1 family, member B1	55					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	AAGACCTTCCCGACGGTCAAC	0.597000													37	63					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52200125	52200125	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:52200125A>G	ENST00000354534.5	+	27	5033	c.4855A>G	c.(4855-4857)Atc>Gtc	p.I1619V	SCN8A_ENST00000545061.1_Missense_Mutation_p.I1578V	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1619					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	ATTCCGAGTCATCCGATTGGC	0.458000													88	116					0	0	1	0	0
BCAS3	54828	broad.mit.edu	37	17	58767096	58767096	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:58767096T>C	ENST00000589222.1	+	4	256	c.188T>C	c.(187-189)gTc>gCc	p.V63A	BCAS3_ENST00000407086.3_Missense_Mutation_p.V63A|BCAS3_ENST00000408905.3_Missense_Mutation_p.V63A|BCAS3_ENST00000588462.1_Missense_Mutation_p.V63A|BCAS3_ENST00000390652.5_Missense_Mutation_p.V63A			Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3	63						nucleus				NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(24)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			ATAGTCTGGGTCAGATTTGAA	0.328000													19	30					0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109694816	109694816	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:109694816T>C	ENST00000465301.2	+	3	1217	c.971T>C	c.(970-972)cTa>cCa	p.L324P	RGAG1_ENST00000540313.1_Missense_Mutation_p.L324P	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	324										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						TCCACACCGCTACTGTCAGTC	0.502000													36	364					0	0	1	0	0
RNF169	254225	broad.mit.edu	37	11	74547475	74547475	+	Missense_Mutation	SNP	C	C	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:74547475C>G	ENST00000299563.4	+	6	1840	c.1827C>G	c.(1825-1827)agC>agG	p.S609R		NM_001098638.1	NP_001092108.1	Q8NCN4	RN169_HUMAN	ring finger protein 169	609							zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	15						TAGTTGAGAGCCTAAGTGAAG	0.423000													35	65					0	0	1	0	0
VIPAS39	63894	broad.mit.edu	37	14	77920439	77920439	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:77920439G>A	ENST00000553888.1	-	2	517	c.7C>T	c.(7-9)Cgg>Tgg	p.R3W	VIPAS39_ENST00000557658.1_Missense_Mutation_p.R3W|VIPAS39_ENST00000556412.1_Missense_Mutation_p.R29W|VIPAS39_ENST00000448935.2_Missense_Mutation_p.R3W|VIPAS39_ENST00000343765.2_Missense_Mutation_p.R3W|VIPAS39_ENST00000327028.4_Missense_Mutation_p.R3W	NM_001193314.1|NM_001193317.1|NM_022067.3	NP_001180243.1|NP_001180246.1|NP_071350.2			VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog																		CCCTTTGTCCGATTCATCTAC	0.453000													29	28					0	0	1	0	0
TEAD2	8463	broad.mit.edu	37	19	49845739	49845739	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:49845739G>A	ENST00000377214.4	-	10	1557	c.1195C>T	c.(1195-1197)Cga>Tga	p.R399*	TEAD2_ENST00000598810.1_Nonsense_Mutation_p.R400*|TEAD2_ENST00000539846.1_Nonsense_Mutation_p.R268*|TEAD2_ENST00000593945.1_Nonsense_Mutation_p.R400*|TEAD2_ENST00000601519.1_Nonsense_Mutation_p.R399*|TEAD2_ENST00000311227.2_Nonsense_Mutation_p.R396*			Q15562	TEAD2_HUMAN	TEA domain family member 2	396	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)	29		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		ATCATGTATCGCTCAGGCAGC	0.602000													41	54					0	0	1	0	0
RP11-909M7.3	0	broad.mit.edu	37	14	101442876	101442876	+	RNA	SNP	C	C	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:101442876C>G	ENST00000554693.2	+	0	548				SNORD114-19_ENST00000363072.1_RNA																							GTGTGTGGAACTCTGAGGTCC	0.323000													49	72					0	0	1	0	0
CNOT11	55571	broad.mit.edu	37	2	101883155	101883155	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:101883155A>G	ENST00000289382.3	+	5	1215	c.1052A>G	c.(1051-1053)gAa>gGa	p.E351G		NM_017546.4	NP_060016.3			CCR4-NOT transcription complex, subunit 11																		GGTGAGTTGGAAAAAGACCCC	0.398000													65	80					0	0	1	0	0
PARG	8505	broad.mit.edu	37	10	51069693	51069693	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:51069693T>C	ENST00000402038.3	-	8	690	c.691A>G	c.(691-693)Aca>Gca	p.T231A		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	716					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity			endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGCAATCGTGTCAAGGGTTTT	0.358000													8	8					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62201259	62201259	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:62201259G>A	ENST00000261517.5	-	65	8983	c.8910C>T	c.(8908-8910)taC>taT	p.Y2970Y	VPS13C_ENST00000395898.3_Silent_p.Y2927Y|VPS13C_ENST00000249837.3_Silent_p.Y2927Y|VPS13C_ENST00000395896.4_Silent_p.Y2970Y	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	2970					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						ATCCCTCATGGTAATCAGAAA	0.378000													24	30					0	0	1	0	0
MST1	4485	broad.mit.edu	37	3	49723549	49723549	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:49723549G>A	ENST00000449682.2	-	9	1454	c.1093C>T	c.(1093-1095)Cgc>Tgc	p.R365C	MST1_ENST00000383728.3_3'UTR	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	351					proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AAGGCCGCGCGCATGCCGGGC	0.672000													17	15					0	0	1	0	0
RPUSD2	27079	broad.mit.edu	37	15	40861959	40861959	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:40861959G>T	ENST00000315616.7	+	1	461	c.423G>T	c.(421-423)aaG>aaT	p.K141N	RPUSD2_ENST00000559271.1_Splice_Site_p.K141_splice	NM_152260.1	NP_689473.1	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing 2	141					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			kidney(4)|lung(4)|skin(3)	11		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)		GCCTGCGTAAGGTGCGGCCCT	0.607000													3	19					0.004672	0.00472589	1	1	0
CXorf21	80231	broad.mit.edu	37	X	30578299	30578299	+	Nonsense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:30578299G>T	ENST00000378962.3	-	3	496	c.174C>A	c.(172-174)tgC>tgA	p.C58*		NM_025159.2	NP_079435.1	Q9HAI6	CX021_HUMAN	chromosome X open reading frame 21	58										kidney(1)|large_intestine(3)|lung(13)|ovary(1)|stomach(1)|urinary_tract(1)	20						CAGATGATTTGCAGCTCACGT	0.468000													101	134					1.61169e-53	1.82852e-53	1	1	0
MSH4	4438	broad.mit.edu	37	1	76262890	76262890	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:76262890G>A	ENST00000263187.3	+	1	324	c.220G>A	c.(220-222)Gcg>Acg	p.A74T		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	74					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						TCCCTGCCCCGCGCCAAACTC	0.672000								Mismatch excision repair (MMR)					7	7					0	0	1	0	0
PUS7L	83448	broad.mit.edu	37	12	44139886	44139886	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:44139886A>G	ENST00000416848.2	-	4	1714	c.1226T>C	c.(1225-1227)cTg>cCg	p.L409P	PUS7L_ENST00000431332.3_Missense_Mutation_p.L96P|PUS7L_ENST00000344862.5_Missense_Mutation_p.L409P|PUS7L_ENST00000551923.1_Missense_Mutation_p.L409P	NM_001098615.1|NM_001271826.1	NP_001092085.1|NP_001258755.1	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	409					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(15)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		TCTCTCCCTCAGGTTTGCAGA	0.338000													6	13					0	0	1	0	0
SECISBP2	79048	broad.mit.edu	37	9	91964840	91964840	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:91964840A>G	ENST00000375807.3	+	13	1959	c.1888A>G	c.(1888-1890)Agg>Ggg	p.R630G	SECISBP2_ENST00000339901.4_Missense_Mutation_p.R557G|SECISBP2_ENST00000534113.2_Missense_Mutation_p.R562G	NM_024077.3	NP_076982.3	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	630					translation	nucleus	mRNA 3'-UTR binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(3)|skin(2)	32						CCGCAGATTCAGGGAGTGAGT	0.567000													30	38					0	0	1	0	0
KRT4	3851	broad.mit.edu	37	12	53202570	53202570	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:53202570C>T	ENST00000293774.4	-	5	1391	c.1121G>A	c.(1120-1122)cGc>cAc	p.R374H	KRT4_ENST00000458244.2_Missense_Mutation_p.R280H|KRT4_ENST00000551956.1_Missense_Mutation_p.R300H			B4DRS2	B4DRS2_HUMAN	keratin 4	300						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						GTCCAGGTTGCGGTTGTTGTC	0.592000													31	47					0	0	1	0	0
RABGGTA	5875	broad.mit.edu	37	14	24734837	24734837	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:24734837C>T	ENST00000399409.3	-	16	2171	c.1688G>A	c.(1687-1689)aGc>aAc	p.S563N	RABGGTA_ENST00000560777.1_Missense_Mutation_p.S172N|RABGGTA_ENST00000216840.6_Missense_Mutation_p.S563N	NM_004581.5	NP_004572.3	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase, alpha subunit	563					visual perception		Rab geranylgeranyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)	12				GBM - Glioblastoma multiforme(265;0.0184)		GAGGACGCTGCTAACTGAAGG	0.582000													26	19					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29822253	29822253	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:29822253G>A	ENST00000375398.2	-	10	1492	c.1043C>T	c.(1042-1044)gCc>gTc	p.A348V	SVIL_ENST00000375400.3_Intron|SVIL_ENST00000355867.4_Missense_Mutation_p.A348V			O95425	SVIL_HUMAN	supervillin	348					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CCTATCAAAGGCTGAGTGCTC	0.572000													50	41					0	0	1	0	0
LYN	4067	broad.mit.edu	37	8	56863330	56863330	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:56863330T>C	ENST00000520220.2	+	6	685	c.411T>C	c.(409-411)agT>agC	p.S137S	LYN_ENST00000519728.1_Silent_p.S158S	NM_001111097.2	NP_001104567.1	P07948	LYN_HUMAN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	158	SH2.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			TTAGAGAAAGTGAAACATTAA	0.373000													25	122					0	0	1	0	0
PLCXD1	55344	broad.mit.edu	37	X	215973	215973	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:215973G>A	ENST00000381657.2	+	7	1457	c.943G>A	c.(943-945)Gcg>Acg	p.A315T	PLCXD1_ENST00000399012.1_Missense_Mutation_p.A315T|PLCXD1_ENST00000381663.3_Missense_Mutation_p.A315T	NM_018390.3	NP_060860.1	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 1	315					intracellular signal transduction|lipid metabolic process		phospholipase C activity			endometrium(3)|large_intestine(1)|lung(7)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGACGTCATCGCGCTCAATCA	0.617000													26	35					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29812587	29812587	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:29812587C>A	ENST00000375398.2	-	17	3405	c.2956G>T	c.(2956-2958)Gac>Tac	p.D986Y	SVIL_ENST00000375400.3_Missense_Mutation_p.D560Y|SVIL_ENST00000355867.4_Missense_Mutation_p.D986Y			O95425	SVIL_HUMAN	supervillin	986					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				TTATGGCTGTCTCCTTCCCTG	0.532000													37	58					1.36161e-19	1.50017e-19	1	1	0
ZNFX1	57169	broad.mit.edu	37	20	47892343	47892343	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:47892343G>A	ENST00000396105.1	-	2	280	c.34C>T	c.(34-36)Ccc>Tcc	p.P12S	ZNFX1_ENST00000371752.1_Missense_Mutation_p.P12S|ZNFX1_ENST00000371754.4_Missense_Mutation_p.P12S	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	12							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GAATTCCTGGGCCTGGCATCC	0.423000													24	63					0	0	1	0	0
SPG7	6687	broad.mit.edu	37	16	89617001	89617001	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:89617001C>T	ENST00000268704.2	+	13	1778	c.1763C>T	c.(1762-1764)aCg>aTg	p.T588M		NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	588					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		CTGGAGCACACGGAGGCCGTG	0.612000													46	45					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32065702	32065702	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:32065702C>T	ENST00000375244.3	-	2	475	c.274G>A	c.(274-276)Gag>Aag	p.E92K	TNXB_ENST00000375247.2_Missense_Mutation_p.E92K|TNXB_ENST00000479795.1_Missense_Mutation_p.E92K			P22105	TENX_HUMAN	tenascin XB	92					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						ACTGGGGGCTCGGTGCCTGGG	0.607000													28	17					0	0	1	0	0
GPR132	29933	broad.mit.edu	37	14	105518408	105518408	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:105518408C>T	ENST00000329797.3	-	4	977	c.66G>A	c.(64-66)ccG>ccA	p.P22P	GPR132_ENST00000392585.2_Silent_p.P13P|GPR132_ENST00000546679.1_5'UTR|GPR132_ENST00000539291.2_Silent_p.P22P	NM_013345.2	NP_037477.1	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	22					response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	18		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		GGGAGGCCCACGGGGCAGTGG	0.622000													65	70					0	0	1	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43473179	43473179	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:43473179C>A	ENST00000532038.1	-	15	1892	c.1757G>T	c.(1756-1758)cGt>cTt	p.R586L	ARHGAP27_ENST00000455881.1_Missense_Mutation_p.R467L|ARHGAP27_ENST00000528384.1_Missense_Mutation_p.R440L|ARHGAP27_ENST00000428638.1_Missense_Mutation_p.R808L|ARHGAP27_ENST00000442348.1_Missense_Mutation_p.R781L|ARHGAP27_ENST00000532891.2_Missense_Mutation_p.R786L|ARHGAP27_ENST00000376922.2_Missense_Mutation_p.R467L			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	808	PH.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					CACCAAGTCACGCACACAGCG	0.692000													10	13					0.00621372	0.00627814	1	1	0
PCDH10	57575	broad.mit.edu	37	4	134073201	134073201	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:134073201G>A	ENST00000264360.4	+	1	2732	c.1906G>A	c.(1906-1908)Ggg>Agg	p.G636R		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	636	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		CTGGCGCACCGGGGAGCTGCG	0.682000													43	67					0	0	1	0	0
OPRD1	4985	broad.mit.edu	37	1	29189255	29189255	+	Splice_Site	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:29189255C>T	ENST00000234961.2	+	3	821	c.577_splice	c.e3-1	p.D193_splice		NM_000911.3	NP_000902.3	P41143	OPRD_HUMAN	opioid receptor, delta 1	193					immune response|protein import into nucleus, translocation	integral to plasma membrane	delta-opioid receptor activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;0.000947)|all_lung(284;0.00131)|Renal(390;0.00758)|Breast(348;0.00765)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-07)|COAD - Colon adenocarcinoma(152;7.51e-06)|STAD - Stomach adenocarcinoma(196;0.00306)|BRCA - Breast invasive adenocarcinoma(304;0.0241)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)	Butorphanol(DB00611)|Codeine(DB00318)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Loperamide(DB00836)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pimozide(DB01100)|Propoxyphene(DB00647)	GCGGCCCAGACGGGGCAGTGG	0.637000													20	23					0	0	1	0	0
OGFOD3	79701	broad.mit.edu	37	17	80356186	80356186	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:80356186C>T	ENST00000313056.5	-	8	860	c.709G>A	c.(709-711)Ggc>Agc	p.G237S	OGFOD3_ENST00000329197.5_Missense_Mutation_p.G237S	NM_024648.2|NM_175902.4	NP_078924.1|NP_787098.3			2-oxoglutarate and iron-dependent oxygenase domain containing 3																		TCGAAGGAGCCGTAGGTCACC	0.572000													15	31					0	0	1	0	0
KTI12	112970	broad.mit.edu	37	1	52498467	52498467	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:52498467G>A	ENST00000371614.1	-	1	1021	c.967C>T	c.(967-969)Cgc>Tgc	p.R323C	TXNDC12_ENST00000371626.4_Intron|TXNDC12_ENST00000472624.1_Intron	NM_138417.2	NP_612426.1	Q96EK9	KTI12_HUMAN	KTI12 homolog, chromatin associated (S. cerevisiae)	323							ATP binding			central_nervous_system(2)|endometrium(1)|kidney(1)|lung(4)|ovary(1)|stomach(2)|urinary_tract(1)	12						ATAAACTGGCGACGAAGGCGA	0.537000													63	61					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21484616	21484616	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:21484616C>T	ENST00000313654.9	+	51	6814	c.6573C>T	c.(6571-6573)gaC>gaT	p.D2191D	LAMA3_ENST00000269217.6_Silent_p.D582D|LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000399516.3_Silent_p.D2135D|LAMA3_ENST00000587184.1_Silent_p.D526D	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2191	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGGCCGAGGACGCAGCCAACA	0.582000													14	17					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40574467	40574467	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr21:40574467G>T	ENST00000342449.3	-	38	4447	c.4369C>A	c.(4369-4371)Ctc>Atc	p.L1457I	BRWD1_ENST00000333229.2_Missense_Mutation_p.L1457I|BRWD1_ENST00000380800.3_Missense_Mutation_p.L1457I	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1457					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TTCGGCTTGAGGTTTCTGGCC	0.358000													12	19					3.07112e-06	3.17614e-06	1	1	0
CRNN	49860	broad.mit.edu	37	1	152384693	152384693	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:152384693T>C	ENST00000271835.3	-	2	79	c.17A>G	c.(16-18)cAa>cGa	p.Q6R	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	6					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATTAATGTTTTGCAGTAACTG	0.493000													67	87					0	0	1	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87445609	87445609	+	Missense_Mutation	SNP	A	A	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:87445609A>C	ENST00000268616.4	-	12	2524	c.2307T>G	c.(2305-2307)caT>caG	p.H769Q		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	769	His-rich.				cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GGGGCTGCtgatggtggtggt	0.667000													25	30					0	0	1	0	0
CXXC1	30827	broad.mit.edu	37	18	47811722	47811722	+	Splice_Site	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:47811722C>A	ENST00000285106.6	-	6	1354		c.e6-1		CXXC1_ENST00000412036.2_Splice_Site|CXXC1_ENST00000589940.1_Splice_Site	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1						histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						TGTACGATTCCTGTGCCGGCA	0.672000													25	42					2.44723e-14	2.62695e-14	1	1	0
GAS2L2	246176	broad.mit.edu	37	17	34074161	34074161	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:34074161G>T	ENST00000254466.6	-	5	986	c.959C>A	c.(958-960)cCt>cAt	p.P320H	GAS2L2_ENST00000587565.1_Missense_Mutation_p.P304H	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	320					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCAGTCCACAGGGGGTGGTGG	0.652000													70	98					4.79706e-38	5.40055e-38	1	1	0
MORC1	27136	broad.mit.edu	37	3	108812302	108812302	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:108812302T>C	ENST00000232603.5	-	8	752	c.670A>G	c.(670-672)Atg>Gtg	p.M224V	MORC1_ENST00000483760.1_Missense_Mutation_p.M224V	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	224					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						GCTCCAGCCATCAGTATATCT	0.423000													22	31					0	0	1	0	0
IRS1	3667	broad.mit.edu	37	2	227661891	227661891	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:227661891G>A	ENST00000305123.4	-	1	2584	c.1564C>T	c.(1564-1566)Cga>Tga	p.R522*		NM_005544.2	NP_005535.1	P35568	IRS1_HUMAN	insulin receptor substrate 1	522					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(10)|lung(33)|ovary(6)|pancreas(1)|prostate(1)|urinary_tract(2)	69		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GTTCTCTTTCGGAACCGATTA	0.577000											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	59					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52676360	52676360	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:52676360C>T	ENST00000355568.4	-	10	817	c.678G>A	c.(676-678)ccG>ccA	p.P226P		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	226	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		GAGAAAACCCCGGAGATATTG	0.423000													112	151					0	0	1	0	0
MEIOB	254528	broad.mit.edu	37	16	1891830	1891830	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:1891830C>T	ENST00000412554.2	-	11	1219	c.1025G>A	c.(1024-1026)cGa>cAa	p.R342Q	MEIOB_ENST00000470044.1_Missense_Mutation_p.R135Q|MEIOB_ENST00000452149.2_Missense_Mutation_p.R342Q|MEIOB_ENST00000325962.3_Missense_Mutation_p.R342Q|MEIOB_ENST00000397344.3_Missense_Mutation_p.R342Q|LA16c-429E7.1_ENST00000570247.1_RNA	NM_001163560.2	NP_001157032.1			meiosis specific with OB domains																		CCATCTATTTCGAACTACTTT	0.313000													13	14					0	0	1	0	0
GRXCR2	643226	broad.mit.edu	37	5	145252292	145252292	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:145252292C>T	ENST00000377976.1	-	1	239	c.240G>A	c.(238-240)ctG>ctA	p.L80L		NM_001080516.1	NP_001073985.1	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	80										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						TCTGAGCAGTCAGCTTAGGGG	0.517000													42	66					0	0	1	0	0
ROGDI	79641	broad.mit.edu	37	16	4848176	4848176	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:4848176C>T	ENST00000322048.7	-	8	919	c.541G>A	c.(541-543)Gcc>Acc	p.A181T	ROGDI_ENST00000586336.1_5'UTR	NM_024589.2	NP_078865.1	Q9GZN7	ROGDI_HUMAN	rogdi homolog (Drosophila)	181						intracellular				endometrium(2)|lung(1)|ovary(1)|skin(1)	5						AGGGCAGGGGCGAACATCCGC	0.652000													7	25					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240601375	240601375	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:240601375C>T	ENST00000319653.9	+	16	5155	c.4925C>T	c.(4924-4926)aCg>aTg	p.T1642M	FMN2_ENST00000545751.1_Missense_Mutation_p.T238M	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1642	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TTGGAGACCACGGCATATTTC	0.378000													38	77					0	0	1	0	0
KIF11	3832	broad.mit.edu	37	10	94408154	94408154	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:94408154C>T	ENST00000260731.3	+	19	2823	c.2733C>T	c.(2731-2733)tgC>tgT	p.C911C		NM_004523.3	NP_004514.2	P52732	KIF11_HUMAN	kinesin family member 11	911					blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGCTTAATTGCTTTCTGGAAC	0.299000													30	94					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69009342	69009342	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:69009342G>A	ENST00000288368.4	+	22	2736	c.2459G>A	c.(2458-2460)gGt>gAt	p.G820D	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	820					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity	p.G820A(2)		NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CTGGAATATGGTGTCGTGTAT	0.453000													121	44					0	0	1	0	0
OR51A7	119687	broad.mit.edu	37	11	4928979	4928979	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:4928979A>G	ENST00000359350.4	+	1	380	c.380A>G	c.(379-381)cAc>cGc	p.H127R	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTTGCCATTCACAATCCCTTA	0.403000													34	44					0	0	1	0	0
POLQ	10721	broad.mit.edu	37	3	121190985	121190985	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:121190985T>C	ENST00000264233.5	-	22	6698	c.6570A>G	c.(6568-6570)ttA>ttG	p.L2190L		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	2190					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		GTAAAGGATGTAATGCCTTTA	0.348000								DNA polymerases (catalytic subunits)					15	27					0	0	1	0	0
GOT1	2805	broad.mit.edu	37	10	101163312	101163312	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:101163312G>A	ENST00000370508.5	-	7	900	c.873C>T	c.(871-873)atC>atT	p.I291I	GOT1_ENST00000543866.1_Silent_p.I270I	NM_002079.2	NP_002070.1	P17174	AATC_HUMAN	glutamic-oxaloacetic transaminase 1, soluble	291					aspartate catabolic process|cellular response to insulin stimulus|gluconeogenesis|response to glucocorticoid stimulus	cytosol	L-aspartate:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)	16		Ovarian(717;0.028)|Colorectal(252;0.234)		Epithelial(162;4.76e-10)|all cancers(201;3.84e-08)	L-Aspartic Acid(DB00128)|L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TAATCCGCACGATCTTCTCCA	0.537000													93	67					0	0	1	0	0
SDAD1P1	0	broad.mit.edu	37	8	26236877	26236877	+	RNA	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:26236877C>T	ENST00000519902.1	-	0	3071																											TAGCATTCTTCTTGGAATGGA	0.343000													5	17					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508511	106508511	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:106508511C>T	ENST00000359195.3	+	2	815	c.505C>T	c.(505-507)Cac>Tac	p.H169Y	PIK3CG_ENST00000440650.2_Missense_Mutation_p.H169Y|PIK3CG_ENST00000496166.1_Missense_Mutation_p.H169Y	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	169					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						CAGCAACGTGCACGACGATGA	0.677000													30	18					0	0	1	0	0
HIST1H3C	8352	broad.mit.edu	37	6	26045754	26045754	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:26045754C>A	ENST00000540144.1	+	1	116	c.116C>A	c.(115-117)cCt>cAt	p.P39H		NM_003531.2	NP_003522.1	P68431	H31_HUMAN	histone cluster 1, H3c	39					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|skin(1)	8						GTGAAGAAACCTCATCGCTAC	0.637000													80	50					5.04879e-28	5.6549e-28	1	1	0
MRPS2	51116	broad.mit.edu	37	9	138392884	138392884	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:138392884G>A	ENST00000371785.1	+	3	293	c.84G>A	c.(82-84)aaG>aaA	p.K28K	MRPS2_ENST00000488610.1_3'UTR|MRPS2_ENST00000241600.5_Silent_p.K28K|C9orf116_ENST00000371791.1_Intron			Q9Y399	RT02_HUMAN	mitochondrial ribosomal protein S2	28					translation	mitochondrion|small ribosomal subunit	structural constituent of ribosome			large_intestine(2)|lung(1)|prostate(2)|urinary_tract(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.46e-53)|Epithelial(140;2.04e-47)|all cancers(34;1.23e-42)		TTCTCGGGAAGGCGACCCCCC	0.711000													17	25					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101768587	101768587	+	Splice_Site	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:101768587G>A	ENST00000261637.4	+	55	7307	c.7131_splice	c.e55-1	p.R2378_splice		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	2378					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						TTTTGGTAGCGCTTAAATAGA	0.398000													44	99					0	0	1	0	0
CPSF2	53981	broad.mit.edu	37	14	92604647	92604647	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:92604647C>T	ENST00000298875.4	+	7	902	c.617C>T	c.(616-618)aCa>aTa	p.T206I		NM_017437.2	NP_059133.1	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2, 100kDa	206					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	24		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		TTCAATGCTACATATGTACAG	0.333000													4	63					0	0	1	0	0
EIF4G2	1982	broad.mit.edu	37	11	10825100	10825100	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:10825100A>G	ENST00000526148.1	-	9	1250	c.740T>C	c.(739-741)aTg>aCg	p.M247T	EIF4G2_ENST00000396525.2_Missense_Mutation_p.M247T|EIF4G2_ENST00000339995.5_Missense_Mutation_p.M247T|EIF4G2_ENST00000525681.1_Missense_Mutation_p.M247T	NM_001172705.1	NP_001166176.1	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4 gamma, 2	247	MIF4G.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	43				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		ATCCTCTCCCATATCTTTGAG	0.423000													29	51					0	0	1	0	0
NAA10	8260	broad.mit.edu	37	X	153196294	153196294	+	Missense_Mutation	SNP	A	A	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:153196294A>T	ENST00000464845.1	-	7	711	c.393T>A	c.(391-393)agT>agA	p.S131R	NAA10_ENST00000370009.1_Missense_Mutation_p.S116R|NAA10_ENST00000393712.3_Missense_Mutation_p.S131R|NAA10_ENST00000370015.4_Missense_Mutation_p.S131R	NM_001256120.1|NM_003491.3	NP_001243049.1|NP_003482.1	P41227	NAA10_HUMAN	N(alpha)-acetyltransferase 10, NatA catalytic subunit	131	N-acetyltransferase.				DNA packaging|internal protein amino acid acetylation|N-terminal protein amino acid acetylation	cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(3)|ovary(1)|prostate(1)	10						GCTCCACTTCACTGATCCTGG	0.587000													64	98					0	0	1	0	0
GEM	2669	broad.mit.edu	37	8	95264399	95264399	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:95264399A>G	ENST00000297596.2	-	4	725	c.461T>C	c.(460-462)cTg>cCg	p.L154P	GEM_ENST00000396194.2_Missense_Mutation_p.L154P	NM_005261.3	NP_005252.1	P55040	GEM_HUMAN	GTP binding protein overexpressed in skeletal muscle	154					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			GTAGACAATCAGGTATGCGTC	0.517000													25	137					0	0	1	0	0
FLRT1	23769	broad.mit.edu	37	11	63884829	63884829	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:63884829C>T	ENST00000246841.3	+	2	2133	c.1090C>T	c.(1090-1092)Cgg>Tgg	p.R364W	MACROD1_ENST00000255681.6_Intron	NM_013280.4	NP_037412.2	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein 1	336					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|endometrium(3)|large_intestine(6)|lung(2)|prostate(1)|urinary_tract(1)	14						TGAGAAGGTCCGGGGCATGGC	0.657000													43	53					0	0	1	0	0
E2F8	79733	broad.mit.edu	37	11	19255993	19255993	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:19255993G>A	ENST00000527884.1	-	6	1074	c.842C>T	c.(841-843)aCg>aTg	p.T281M	RP11-428C19.4_ENST00000527978.1_RNA|E2F8_ENST00000250024.4_Missense_Mutation_p.T281M	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	281					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TATCTGAGGCGTTGACACCAA	0.403000													82	105					0	0	1	0	0
PCDHB16	0	broad.mit.edu	37	5	140564303	140564303	+	Silent	SNP	C	C	T	rs144790293	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140564303C>T	ENST00000361016.2	+	1	3324	c.2169C>T	c.(2167-2169)ggC>ggT	p.G723G		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		723					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTCGGTGGGCCGCTGCTCGA	0.662000													152	145					0	0	1	0	0
NOXO1	0	broad.mit.edu	37	16	2030447	2030447	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:2030447G>A	ENST00000354249.4	-	4	688	c.319C>T	c.(319-321)Cgc>Tgc	p.R107C	NOXO1_ENST00000566005.1_Missense_Mutation_p.R112C|NOXO1_ENST00000397280.4_Missense_Mutation_p.R113C|TBL3_ENST00000568546.1_3'UTR|NOXO1_ENST00000356120.4_Missense_Mutation_p.R108C	NM_001267721.1|NM_144603.3|NM_172167.2|NM_172168.2	NP_001254650.1|NP_653204.1|NP_751907.1|NP_751908.1	Q8NFA2	NOXO1_HUMAN	NADPH oxidase organizer 1	113	PX.				cell communication|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst	NADPH oxidase complex	enzyme binding|phosphatidylinositol binding|superoxide-generating NADPH oxidase activator activity			lung(2)	2						CGTGCCACGCGCTCTGCAGTC	0.687000													34	52					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147914501	147914501	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:147914501G>A	ENST00000361727.3	+	19	3648	c.3132G>A	c.(3130-3132)ccG>ccA	p.P1044P	CNTNAP2_ENST00000538075.1_Silent_p.P103P	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1044					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding	p.P1044P(1)		NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ACTCCCACCCGGACCTGGCAC	0.562000										HNSCC(39;0.1)			51	66					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219895832	219895832	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:219895832A>G	ENST00000341552.5	-	8	1094	c.1011T>C	c.(1009-1011)gcT>gcC	p.A337A	CCDC108_ENST00000453220.1_Silent_p.A337A|CCDC108_ENST00000410037.1_Silent_p.A272A|CCDC108_ENST00000409865.3_Silent_p.A326A|CCDC108_ENST00000441968.1_Silent_p.A337A	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	337						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTCACCCACAGCCTGCAGCT	0.677000													4	6					0	0	1	0	0
SAFB	6294	broad.mit.edu	37	19	5661692	5661692	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:5661692G>A	ENST00000292123.5	+	15	2133	c.2026G>A	c.(2026-2028)Gtg>Atg	p.V676M	SAFB_ENST00000538656.1_Missense_Mutation_p.V518M|SAFB_ENST00000454510.1_Missense_Mutation_p.V607M|SAFB_ENST00000433404.1_Missense_Mutation_p.V506M|SAFB_ENST00000592224.1_Missense_Mutation_p.V675M|SAFB_ENST00000588852.1_Missense_Mutation_p.V676M	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B	676	Arg-rich.|Glu-rich.|Interaction with POLR2A.|Interaction with SAFB2.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(1)	23				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		ACGCATGCACGTGGAGCACGA	0.711000													12	19					0	0	1	0	0
TECPR1	25851	broad.mit.edu	37	7	97846804	97846804	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:97846804G>A	ENST00000447648.2	-	26	3695	c.3396C>T	c.(3394-3396)gaC>gaT	p.D1132D	TECPR1_ENST00000379795.3_Silent_p.D1134D			Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	1132						integral to membrane	protein binding			central_nervous_system(2)|endometrium(8)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CAGAGATATGGTCCCAGCCTC	0.682000													11	11					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23914022	23914022	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:23914022A>G	ENST00000382298.3	-	10	4581	c.3993T>C	c.(3991-3993)caT>caC	p.H1331H	SACS_ENST00000382292.3_Silent_p.H1331H|SACS_ENST00000402364.1_Silent_p.H581H	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1331					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CCATGGAAATATGATCTGATG	0.338000													18	19					0	0	1	0	0
HOXD1	3231	broad.mit.edu	37	2	177053603	177053603	+	Missense_Mutation	SNP	C	C	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:177053603C>G	ENST00000331462.4	+	1	297	c.74C>G	c.(73-75)cCc>cGc	p.P25R	HOXD-AS1_ENST00000413969.1_RNA	NM_024501.1	NP_078777.1	Q9GZZ0	HXD1_HUMAN	homeobox D1	25						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.0226)		AGCTTGGCACCCAAGTTCTGC	0.706000													10	15					0	0	1	0	0
GP1BA	2811	broad.mit.edu	37	17	4836674	4836674	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:4836674G>A	ENST00000329125.5	+	2	850	c.775G>A	c.(775-777)Gtg>Atg	p.V259M		NM_000173.5	NP_000164.5	E7ES66	E7ES66_HUMAN	glycoprotein Ib (platelet), alpha polypeptide	259										central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(5)|stomach(1)|urinary_tract(1)	20						GACCTCTAACGTGGCCAGTGT	0.502000													47	62					0	0	1	0	0
AIM1	202	broad.mit.edu	37	6	107008716	107008716	+	Missense_Mutation	SNP	A	A	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:107008716A>C	ENST00000369066.3	+	17	5157	c.4670A>C	c.(4669-4671)cAg>cCg	p.Q1557P	AIM1_ENST00000535438.1_Missense_Mutation_p.Q376P	NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1557	Beta/gamma crystallin 'Greek key' 12.						sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AGAGGGCGACAGTTCCTATTG	0.403000													87	57					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147113791	147113791	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:147113791G>A	ENST00000383075.3	-	3	1048	c.536C>T	c.(535-537)cCg>cTg	p.P179L	ZIC4_ENST00000473123.1_Missense_Mutation_p.P179L|ZIC4_ENST00000491672.1_Intron|ZIC4_ENST00000525172.2_Missense_Mutation_p.P229L|ZIC4_ENST00000425731.3_Missense_Mutation_p.P217L|ZIC4_ENST00000484399.1_Missense_Mutation_p.P179L	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	179						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						TCCCTGGCGCGGACACTCCTC	0.587000													25	190					0	0	1	0	0
LGR4	55366	broad.mit.edu	37	11	27406980	27406980	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:27406980T>C	ENST00000379214.4	-	5	880	c.437A>G	c.(436-438)gAg>gGg	p.E146G	LGR4_ENST00000389858.4_Missense_Mutation_p.E122G|LGR4_ENST00000480977.2_Missense_Mutation_p.E98G	NM_018490.2	NP_060960.2	Q9BXB1	LGR4_HUMAN	leucine-rich repeat containing G protein-coupled receptor 4	146						integral to membrane|plasma membrane	protein-hormone receptor activity			NS(3)|breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(10)|ovary(1)	32						AAAACTGTCCTCGGGGACTGA	0.473000													22	28					0	0	1	0	0
TSPAN16	26526	broad.mit.edu	37	19	11409591	11409591	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:11409591C>T	ENST00000316737.1	+	3	461	c.311C>T	c.(310-312)gCt>gTt	p.A104V	TSPAN16_ENST00000590327.1_Missense_Mutation_p.A104V|TSPAN16_ENST00000592955.1_Intron	NM_012466.2	NP_036598.1	Q9UKR8	TSN16_HUMAN	tetraspanin 16	104						integral to membrane				breast(1)|endometrium(3)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(2)|stomach(1)	12						GAAGTTACAGCTGCCACAGTG	0.512000													30	69					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60059865	60059865	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:60059865T>C	ENST00000397786.2	-	16	3575	c.3499A>G	c.(3499-3501)Agg>Ggg	p.R1167G		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1167					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GAGGTAGCCCTGAGAGCTTCA	0.348000													43	55					0	0	1	0	0
TIFAB	497189	broad.mit.edu	37	5	134785404	134785404	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:134785404T>C	ENST00000537858.1	-	2	426	c.226A>G	c.(226-228)Aag>Gag	p.K76E		NM_001099221.1	NP_001092691.1	Q6ZNK6	TIFAB_HUMAN	TRAF-interacting protein with forkhead-associated domain, family member B	76	FHA.									breast(1)|endometrium(1)|liver(1)|lung(5)	8			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTCAGGGCCTTGAGGCAGAAG	0.662000													115	95					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885771	88885771	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:88885771C>T	ENST00000319675.3	-	1	525	c.429G>A	c.(427-429)ctG>ctA	p.L143L		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	143								p.L143L(1)		breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						CGAAGCACAGCAGAAGGTGGG	0.562000													110	55					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23915781	23915781	+	Missense_Mutation	SNP	C	C	T	rs143677534	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:23915781C>T	ENST00000382298.3	-	10	2822	c.2234G>A	c.(2233-2235)cGt>cAt	p.R745H	SACS_ENST00000382292.3_Missense_Mutation_p.R745H|SACS_ENST00000402364.1_5'UTR	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	745				RPCTQLQLLNPERFARLIKEV -> FLFDEDSNGKLKMVAV LITSC (in Ref. 4; BAC03486).	cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTTGATAAGACGTGCAAATCG	0.368000													20	30					0	0	1	0	0
RBMX	27316	broad.mit.edu	37	X	135960091	135960091	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:135960091G>A	ENST00000562646.1	-	4	525	c.371C>T	c.(370-372)tCa>tTa	p.S124L	RBMX_ENST00000320676.7_Missense_Mutation_p.S124L|RBMX_ENST00000431446.3_Intron|RBMX_ENST00000570135.1_Intron|RBMX_ENST00000565438.1_5'UTR			P38159	HNRPG_HUMAN	RNA binding motif protein, X-linked	124						catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|urinary_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					TCCTCCCCGTGAGGGAGGTCC	0.547000													36	52					0	0	1	0	0
MOCOS	55034	broad.mit.edu	37	18	33800116	33800116	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:33800116C>T	ENST00000261326.5	+	9	1917	c.1896C>T	c.(1894-1896)ccC>ccT	p.P632P		NM_017947.2	NP_060417.2	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	632					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|liver(1)|lung(15)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43					Pyridoxal Phosphate(DB00114)	AGCAGGAACCCCGGCTCTGCC	0.532000													25	48					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62297595	62297595	+	Missense_Mutation	SNP	C	C	T	rs139799392		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:62297595C>T	ENST00000378024.4	-	5	4568	c.4294G>A	c.(4294-4296)Gca>Aca	p.A1432T	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1432					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTTAGTTTTGCGTCTGGACCT	0.433000													111	186					0	0	1	0	0
TACC3	10460	broad.mit.edu	37	4	1729657	1729657	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:1729657C>T	ENST00000313288.4	+	4	634	c.528C>T	c.(526-528)ggC>ggT	p.G176G		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	176						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			AAGTGTCTGGCAGCCCTGAGC	0.552000													58	73					0	0	1	0	0
MYRF	745	broad.mit.edu	37	11	61537778	61537778	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:61537778G>A	ENST00000278836.5	+	5	617	c.521G>A	c.(520-522)cGc>cAc	p.R174H	TMEM258_ENST00000535042.1_Intron|MYRF_ENST00000265460.5_Missense_Mutation_p.R165H	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		GTGCCCTCCCGCCTGGAGCAT	0.677000													9	10					0	0	1	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87445612	87445612	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:87445612G>A	ENST00000268616.4	-	12	2521	c.2304C>T	c.(2302-2304)caC>caT	p.H768H		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	768	His-rich.				cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GCTGCtgatggtggtggtggt	0.667000													26	30					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119592107	119592107	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:119592107G>A	ENST00000267260.4	+	12	1839	c.1451G>A	c.(1450-1452)cGt>cAt	p.R484H		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	484	Arg-rich.|Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						GAGCGAGCGCGTCGGAGACGT	0.682000													8	20					0	0	1	0	0
FLNA	0	broad.mit.edu	37	X	153588429	153588429	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:153588429C>A	ENST00000422373.1	-	22	3982	c.3734G>T	c.(3733-3735)aGc>aTc	p.S1245I	FLNA_ENST00000369850.3_Missense_Mutation_p.S1245I|FLNA_ENST00000344736.4_Missense_Mutation_p.S1245I|FLNA_ENST00000360319.4_Missense_Mutation_p.S1245I	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	1245					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGCAGCTTGCTGGGGAAGTT	0.632000													47	58					2.56175e-15	2.76001e-15	1	1	0
RERE	473	broad.mit.edu	37	1	8416169	8416169	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:8416169G>A	ENST00000337907.3	-	22	5111	c.4477C>T	c.(4477-4479)Cca>Tca	p.P1493S	RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Missense_Mutation_p.P1493S|RERE_ENST00000377464.1_Missense_Mutation_p.P1225S|RERE_ENST00000476556.1_Missense_Mutation_p.P939S	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1493	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P1493T(1)		central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CCGAAAACTGGGTGGCGAAGC	0.617000													115	161					0	0	1	0	0
ZC3H6	376940	broad.mit.edu	37	2	113067600	113067600	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:113067600T>C	ENST00000409871.1	+	4	876	c.475T>C	c.(475-477)Tac>Cac	p.Y159H	ZC3H6_ENST00000343936.4_Missense_Mutation_p.Y159H	NM_198581.2	NP_940983.2	P61129	ZC3H6_HUMAN	zinc finger CCCH-type containing 6	159							nucleic acid binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(4)|prostate(2)	35						CTTTGGTAACTACGGTCAGGA	0.363000													10	19					0	0	1	0	0
ANXA4	307	broad.mit.edu	37	2	70035051	70035051	+	Missense_Mutation	SNP	A	A	G	rs139920396		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:70035051A>G	ENST00000394295.4	+	6	568	c.320A>G	c.(319-321)gAt>gGt	p.D107G	ANXA4_ENST00000536030.1_Missense_Mutation_p.D23G|ANXA4_ENST00000409920.1_Missense_Mutation_p.D85G	NM_001153.3	NP_001144.1	P09525	ANXA4_HUMAN	annexin A4	105					anti-apoptosis|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	11						GCCGGCACTGATGAGGGCTGC	0.552000													28	41					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68686815	68686815	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:68686815T>C	ENST00000361320.4	+	2	719	c.141T>C	c.(139-141)tgT>tgC	p.C47C	CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.1_Intron|CTNNA3_ENST00000494580.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	47	LRRNT.					integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						TGGTATATTGTGAATCTCAGA	0.423000													20	70					0	0	1	0	0
ZNF770	54989	broad.mit.edu	37	15	35273866	35273866	+	Silent	SNP	A	A	G	rs151315389	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:35273866A>G	ENST00000356321.4	-	3	2114	c.1770T>C	c.(1768-1770)ggT>ggC	p.G590G		NM_014106.3	NP_054825.2	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	590					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)	29		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		GCCCGGTGCTACCAGGAATAA	0.438000													77	95					0	0	1	0	0
ZNF207	7756	broad.mit.edu	37	17	30694992	30694992	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:30694992G>A	ENST00000394670.4	+	10	1292	c.1123G>A	c.(1123-1125)Gca>Aca	p.A375T	ZNF207_ENST00000577908.1_Missense_Mutation_p.A375T|ZNF207_ENST00000394673.2_Missense_Mutation_p.A344T|ZNF207_ENST00000342555.6_Missense_Mutation_p.A378T|ZNF207_ENST00000341711.6_Missense_Mutation_p.A276T|ZNF207_ENST00000321233.6_Missense_Mutation_p.A359T	NM_001098507.1	NP_001091977.1	O43670	ZN207_HUMAN	zinc finger protein 207	359						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|lung(3)|urinary_tract(2)	10		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			AACAACTAGTGCAACCAGTAA	0.398000													37	62					0	0	1	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105924173	105924173	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:105924173C>A	ENST00000393359.2	-	2	1012	c.586G>T	c.(586-588)Ggc>Tgc	p.G196C	TGFBRAP1_ENST00000258449.1_Missense_Mutation_p.G196C			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	196	CNH.				regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						TGGGAGACGCCTGTGCTGTAA	0.622000													94	126					1.63847e-34	1.83751e-34	1	1	0
HIF1A	3091	broad.mit.edu	37	14	62207260	62207260	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:62207260G>T	ENST00000394997.1	+	11	1842	c.1577G>T	c.(1576-1578)aGt>aTt	p.S526I	HIF1A_ENST00000539097.1_Missense_Mutation_p.S549I|HIF1A_ENST00000337138.4_Missense_Mutation_p.S525I|RP11-618G20.1_ENST00000555937.1_RNA|HIF1A_ENST00000323441.6_Missense_Mutation_p.S525I|HIF1A_ENST00000557538.1_Missense_Mutation_p.S466I|HIF1A-AS2_ENST00000554254.1_lincRNA			Q16665	HIF1A_HUMAN	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	525	ODD.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|endometrium(8)|kidney(6)|large_intestine(3)|lung(4)	23				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		TATGTGGATAGTGATATGGTC	0.328000													28	31					5.61819e-17	6.0754e-17	1	1	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72658461	72658461	+	RNA	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:72658461C>A	ENST00000425256.1	-	0	1450					NR_002164.1																						atgaatatggccaactgggtg	0.433000													50	46					3.21987e-24	3.57899e-24	1	1	0
GNAQ	2776	broad.mit.edu	37	9	80343579	80343579	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:80343579C>T	ENST00000286548.4	-	6	962	c.740G>A	c.(739-741)cGa>cAa	p.R247Q	GNAQ_ENST00000397476.3_Missense_Mutation_p.R45Q	NM_002072.3	NP_002063.2	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein), q polypeptide	247					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity			NS(1)|endometrium(3)|eye(229)|kidney(1)|large_intestine(4)|lung(6)|meninges(11)|ovary(1)|prostate(1)|skin(44)|upper_aerodigestive_tract(1)	302						TTCCTCCATTCGGTTCTGGAA	0.333000			Mis		uveal melanoma								53	85					0	0	1	0	0
LTA	4049	broad.mit.edu	37	6	31541415	31541415	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:31541415T>C	ENST00000454783.1	+	4	821	c.563T>C	c.(562-564)aTc>aCc	p.I188T	LTA_ENST00000418386.2_Missense_Mutation_p.I188T	NM_001159740.2	NP_001153212.1	P01374	TNFB_HUMAN	lymphotoxin alpha	188					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(2)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9					Etanercept(DB00005)	ACAGATGGCATCCCCCACCTA	0.522000													21	357					0	0	1	0	0
MYC	4609	broad.mit.edu	37	8	128750639	128750639	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:128750639C>T	ENST00000377970.2	+	2	686	c.176C>T	c.(175-177)gCg>gTg	p.A59V	MYC_ENST00000259523.6_Missense_Mutation_p.A44V|MYC_ENST00000524013.1_Missense_Mutation_p.A58V	NM_002467.4	NP_002458.2	P01106	MYC_HUMAN	v-myc avian myelocytomatosis viral oncogene homolog	44			P -> A (in a Burkitt lymphoma sample).		branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		CAGCCCCCGGCGCCCAGCGAG	0.637000	A59V(RAJI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|A59V(TOLEDO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	3	"""A, T"""	"""IGK@, BCL5, BCL7A , BTG1, TRA@, IGH@"""	"""Burkitt lymphoma,  amplified in other cancers, B-CLL"""						OREG0018982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	88	35					0	0	1	0	0
PTGFRN	5738	broad.mit.edu	37	1	117484351	117484351	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:117484351C>T	ENST00000393203.2	+	2	211	c.64C>T	c.(64-66)Cgt>Tgt	p.R22C		NM_020440.2	NP_065173.2	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor inhibitor	22						endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)	46	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		TTGCCGAGGGCGTGTGGTGAG	0.537000													48	57					0	0	1	0	0
SRSF5	6430	broad.mit.edu	37	14	70235387	70235387	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:70235387G>A	ENST00000553521.1	+	4	1646	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K	SRSF5_ENST00000555349.1_Missense_Mutation_p.E65K|SRSF5_ENST00000554021.1_Missense_Mutation_p.E65K|SRSF5_ENST00000556587.1_3'UTR|SRSF5_ENST00000553548.1_Missense_Mutation_p.E65K|SRSF5_ENST00000557154.1_Missense_Mutation_p.E65K|SRSF5_ENST00000394366.2_Missense_Mutation_p.E65K|SRSF5_ENST00000553635.1_Missense_Mutation_p.E62K|SRSF5_ENST00000451983.2_Missense_Mutation_p.E65K			Q13243	SRSF5_HUMAN	serine/arginine-rich splicing factor 5	65	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding			large_intestine(1)|liver(1)	2						ACTCTGTAGTGAAAGGTGAGA	0.398000													62	82					0	0	1	0	0
PIK3C3	5289	broad.mit.edu	37	18	39575909	39575909	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:39575909C>A	ENST00000262039.4	+	8	928	c.842C>A	c.(841-843)cCt>cAt	p.P281H	PIK3C3_ENST00000398870.3_Missense_Mutation_p.P218H	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	281					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						AGAAGTGGACCTTCTGACCAC	0.348000										TSP Lung(28;0.18)			37	49					4.67007e-22	5.17127e-22	1	1	0
ITGA9	3680	broad.mit.edu	37	3	37544757	37544757	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:37544757T>C	ENST00000264741.5	+	6	957	c.701T>C	c.(700-702)cTg>cCg	p.L234P	ITGA9_ENST00000422441.1_Missense_Mutation_p.L234P	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	234					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TATTTAAAACTGAACGACGAA	0.483000													35	49					0	0	1	0	0
SUCLG1	8802	broad.mit.edu	37	2	84670463	84670463	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:84670463G>A	ENST00000393868.2	-	3	473	c.263C>T	c.(262-264)cCa>cTa	p.P88L		NM_003849.3	NP_003840.2	P53597	SUCA_HUMAN	succinate-CoA ligase, alpha subunit	88					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity			kidney(4)|large_intestine(4)|lung(2)	10					Succinic acid(DB00139)	TCCTTTCCCTGGAGTGGTTCC	0.488000													5	96					0	0	1	0	0
ZBTB14	7541	broad.mit.edu	37	18	5290969	5290969	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:5290969C>T	ENST00000357006.4	-	4	1576	c.1238G>A	c.(1237-1239)aGt>aAt	p.S413N	ZBTB14_ENST00000400143.3_Missense_Mutation_p.S413N	NM_001143823.2|NM_001243704.1	NP_001137295.1|NP_001230633.1			zinc finger and BTB domain containing 14																		CTTCCTTTCACTGTGCATATT	0.532000													42	69					0	0	1	0	0
FSCN1	6624	broad.mit.edu	37	7	5645075	5645075	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:5645075C>T	ENST00000382361.3	+	5	1566	c.1452C>T	c.(1450-1452)acC>acT	p.T484T	FSCN1_ENST00000340250.6_Silent_p.T463T	NM_003088.3	NP_003079.1	Q16658	FSCN1_HUMAN	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	484					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		CGGCGGAAACCGTGGACCCCG	0.662000													5	3					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144945055	144945055	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:144945055G>A	ENST00000525985.1	-	2	2438	c.2367C>T	c.(2365-2367)ccC>ccT	p.P789P				P58107	EPIPL_HUMAN	epiplakin 1	789						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGCCCGTCTCGGGGTCACGCA	0.627000													48	142					0	0	1	0	0
ISLR2	57611	broad.mit.edu	37	15	74425609	74425609	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:74425609G>A	ENST00000361742.3	+	4	1283	c.514G>A	c.(514-516)Gcg>Acg	p.A172T	ISLR2_ENST00000435464.1_Missense_Mutation_p.A172T|ISLR2_ENST00000565159.1_Missense_Mutation_p.A172T|ISLR2_ENST00000419208.1_Missense_Mutation_p.A172T|ISLR2_ENST00000565540.1_Missense_Mutation_p.A172T|ISLR2_ENST00000561975.1_Intron|ISLR2_ENST00000445793.1_Missense_Mutation_p.A172T|ISLR2_ENST00000453268.2_Missense_Mutation_p.A172T	NM_001130136.1|NM_020851.2	NP_001123608.1|NP_065902.1	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing leucine-rich repeat 2	172					positive regulation of axon extension	cell surface|integral to membrane|plasma membrane				breast(3)|endometrium(6)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36						CGCGCTTAGCGCGCTGTCACA	0.667000													70	95					0	0	1	0	0
MSH2	4436	broad.mit.edu	37	2	47707956	47707956	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:47707956G>A	ENST00000406134.1	+	15	2642	c.2580G>A	c.(2578-2580)tcG>tcA	p.S860S	MSH2_ENST00000543555.1_Silent_p.S794S|MSH2_ENST00000461394.1_3'UTR|MSH2_ENST00000233146.2_Silent_p.S860S			P43246	MSH2_HUMAN	mutS homolog 2	860					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.0?(2)|p.?(2)		NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(5)|large_intestine(50)|lung(18)|ovary(5)|prostate(2)|skin(3)|small_intestine(1)|stomach(2)|urinary_tract(1)	112		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TTGGAGAATCGCAAGGATATG	0.383000			"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian"""	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				56	64					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137687154	137687154	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:137687154G>C	ENST00000371817.3	+	34	3206	c.2792G>C	c.(2791-2793)gGc>gCc	p.G931A		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	931	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGGAAGCCTGGCCCCAAGGTA	0.602000													43	78					0	0	1	0	0
GPR142	350383	broad.mit.edu	37	17	72368690	72368690	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:72368690C>T	ENST00000335666.4	+	4	1388	c.1340C>T	c.(1339-1341)gCg>gTg	p.A447V		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	447						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity	p.A447E(1)		central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						GGCATGGCGGCGAAGCCTGTG	0.617000													14	28					0	0	1	0	0
TRAV22	0	broad.mit.edu	37	14	22539003	22539003	+	RNA	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:22539003C>T	ENST00000390450.3	+	0	184																											CCCAGGTTTGCTGTGAGTTGG	0.488000													4	8					0	0	1	0	0
ARSD	414	broad.mit.edu	37	X	2828698	2828698	+	Splice_Site	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:2828698A>G	ENST00000381154.1	-	7	1211		c.e7+1			NM_001669.3	NP_001660.2	P51689	ARSD_HUMAN	arylsulfatase D							lysosome	arylsulfatase activity|metal ion binding			large_intestine(3)|lung(3)	6		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCCACAACTCACCTTTGTAAA	0.453000													18	236					0	0	1	0	0
CCND1	595	broad.mit.edu	37	11	69466022	69466022	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:69466022C>T	ENST00000227507.2	+	5	1087	c.860C>T	c.(859-861)cCc>cTc	p.P287L		NM_053056.2	NP_444284.1	P24385	CCND1_HUMAN	cyclin D1	287					cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding	p.P287L(1)|p.P287H(1)		NS(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|ovary(1)|urinary_tract(1)	23	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	GCTTGCACACCCACCGACGTG	0.716000			T	"""IGH@, FSTL3"""	"""CLL, B-ALL, breast"""					Multiple Myeloma(6;0.086)			10	13					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139418329	139418329	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:139418329G>A	ENST00000277541.6	-	3	318	c.243C>T	c.(241-243)ggC>ggT	p.G81G	NOTCH1_ENST00000491649.1_5'UTR	NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	81	EGF-like 2.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGTCTGCCACGCCTCTGCGGT	0.697000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			13	11					0	0	1	0	0
CLDN5	7122	broad.mit.edu	37	22	19511475	19511475	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:19511475C>T	ENST00000406028.1	-	2	1619	c.559G>A	c.(559-561)Gcg>Acg	p.A187T	CLDN5_ENST00000403084.1_Missense_Mutation_p.A187T|CLDN5_ENST00000413119.2_Missense_Mutation_p.A187T			O00501	CLD5_HUMAN	claudin 5	102					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			liver(1)|lung(2)|prostate(1)	4	Colorectal(54;0.0993)					GTGCACTGCGCGCCCGCCAGG	0.736000													8	8					0	0	1	0	0
ARHGEF26	26084	broad.mit.edu	37	3	153870684	153870684	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:153870684T>C	ENST00000356448.4	+	6	1734	c.1450T>C	c.(1450-1452)Ttc>Ctc	p.F484L	ARHGEF26_ENST00000465093.1_Missense_Mutation_p.F484L|ARHGEF26_ENST00000465817.1_Intron	NM_001251962.1	NP_001238891.1	Q96DR7	ARHGQ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 26	484	DH.				regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	23						GCACCATCTTTTCTCCAATAT	0.378000													3	13					0	0	1	0	0
ALDH1A1	216	broad.mit.edu	37	9	75543858	75543858	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:75543858C>T	ENST00000297785.3	-	4	446	c.392G>A	c.(391-393)cGc>cAc	p.R131H	ALDH1A1_ENST00000482210.1_5'UTR|ALDH1A1_ENST00000376939.1_Missense_Mutation_p.R131H	NM_000689.4	NP_000680.2	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1 family, member A1	131					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)	17					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TGCACAGTAGCGCAATGTTTT	0.428000													48	90					0	0	1	0	0
MROH6	642475	broad.mit.edu	37	8	144649983	144649983	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:144649983G>A	ENST00000398882.3	-	12	2096	c.1840C>T	c.(1840-1842)Ctg>Ttg	p.L614L	MROH6_ENST00000534459.1_5'UTR|MROH6_ENST00000533679.1_5'UTR|MROH6_ENST00000524906.1_5'UTR|MROH6_ENST00000532704.1_5'UTR	NM_001100878.1	NP_001094348.1			maestro heat-like repeat family member 6																		GCCCGGCGCAGGGGGTCCTGT	0.701000													14	45					0	0	1	0	0
GOLIM4	27333	broad.mit.edu	37	3	167754717	167754717	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:167754717A>G	ENST00000470487.1	-	8	1439	c.750T>C	c.(748-750)ccT>ccC	p.P250P	GOLIM4_ENST00000309027.4_Silent_p.P222P	NM_014498.3	NP_055313.1	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	250					transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CTGCTGGATCAGGTTTTCGAA	0.453000													53	93					0	0	1	0	0
PSMB1	5689	broad.mit.edu	37	6	170844432	170844432	+	Missense_Mutation	SNP	C	C	T	rs150833808		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:170844432C>T	ENST00000262193.6	-	6	700	c.602G>A	c.(601-603)cGg>cAg	p.R201Q	PSMB1_ENST00000462957.1_5'UTR	NM_002793.3	NP_002784.1	P20618	PSB1_HUMAN	proteasome (prosome, macropain) subunit, beta type, 1	201					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cell junction|cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.0563)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;7.5e-23)|BRCA - Breast invasive adenocarcinoma(81;4.88e-06)|GBM - Glioblastoma multiforme(31;0.00643)	Bortezomib(DB00188)	TTTCACCAGCCGCATGGCTCT	0.512000													67	49					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48686273	48686273	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:48686273G>A	ENST00000544264.1	-	19	6951	c.6671C>T	c.(6670-6672)aCt>aTt	p.T2224I	CELSR3_ENST00000164024.4_Missense_Mutation_p.T2219I			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2219					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ATAGTGGTCAGTGTGGCCAGT	0.597000													39	43					0	0	1	0	0
UCKL1	54963	broad.mit.edu	37	20	62571740	62571740	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:62571740G>A	ENST00000369908.5	-	13	1655	c.1356C>T	c.(1354-1356)cgC>cgT	p.R452R	UCKL1_ENST00000369892.3_Silent_p.R467R|UCKL1_ENST00000358711.3_3'UTR|UCKL1_ENST00000354216.6_Silent_p.R467R	NM_001193379.1	NP_001180308.1	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	467					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity			endometrium(3)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CCAGGAGCACGCGCACTGCCA	0.632000													18	42					0	0	1	0	0
SPIN1	10927	broad.mit.edu	37	9	91083304	91083304	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:91083304G>A	ENST00000375859.3	+	5	651	c.373G>A	c.(373-375)Gat>Aat	p.D125N	SPIN1_ENST00000469017.2_3'UTR|SPIN1_ENST00000541629.1_Missense_Mutation_p.D125N	NM_006717.2	NP_006708.2	Q9Y657	SPIN1_HUMAN	spindlin 1	125					cell cycle|gamete generation|multicellular organismal development	nucleus	methylated histone residue binding			endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4						TCGAATCAGCGATGCACACTT	0.413000													23	31					0	0	1	0	0
BCL2L1	598	broad.mit.edu	37	20	30253853	30253853	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:30253853C>T	ENST00000307677.4	-	3	1011	c.601G>A	c.(601-603)Gcc>Acc	p.A201T	BCL2L1_ENST00000420653.1_Missense_Mutation_p.A201T|BCL2L1_ENST00000376055.4_Missense_Mutation_p.A138T|BCL2L1_ENST00000376062.2_Missense_Mutation_p.A201T	NM_138578.1	NP_612815.1	Q07817	B2CL1_HUMAN	BCL2-like 1	201					induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			CGGCTCTCGGCTGCTGCATTG	0.557000													38	110					0	0	1	0	0
SYBU	55638	broad.mit.edu	37	8	110587865	110587865	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:110587865G>A	ENST00000399066.3	-	6	1980	c.1253C>T	c.(1252-1254)aCg>aTg	p.T418M	SYBU_ENST00000446070.2_Missense_Mutation_p.T420M|SYBU_ENST00000433638.1_Missense_Mutation_p.T421M|SYBU_ENST00000529175.1_Missense_Mutation_p.T215M|SYBU_ENST00000408908.2_Missense_Mutation_p.T421M|SYBU_ENST00000440310.1_Missense_Mutation_p.T421M|SYBU_ENST00000408889.3_Missense_Mutation_p.T302M|SYBU_ENST00000422135.1_Missense_Mutation_p.T421M|SYBU_ENST00000533895.1_Missense_Mutation_p.T420M|SYBU_ENST00000528647.1_Missense_Mutation_p.T420M|SYBU_ENST00000419099.1_Missense_Mutation_p.T420M|SYBU_ENST00000533171.1_Missense_Mutation_p.T421M|SYBU_ENST00000276646.9_Missense_Mutation_p.T421M|SYBU_ENST00000528331.1_Missense_Mutation_p.T302M|SYBU_ENST00000424158.2_Missense_Mutation_p.T426M|SYBU_ENST00000532779.1_Missense_Mutation_p.T353M|SYBU_ENST00000529690.1_Missense_Mutation_p.T291M|SYBU_ENST00000533065.1_Missense_Mutation_p.T302M	NM_001099756.1	NP_001093226.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)	421						cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						CCCTTCCCCCGTGACCTGCTC	0.522000													22	113					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203025953	203025953	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:203025953G>A	ENST00000367240.2	+	18	2746	c.2219G>A	c.(2218-2220)aGc>aAc	p.S740N	PPFIA4_ENST00000599966.1_Missense_Mutation_p.S255N|PPFIA4_ENST00000414050.2_Missense_Mutation_p.S468N|PPFIA4_ENST00000272198.6_Missense_Mutation_p.S255N|PPFIA4_ENST00000447715.2_Missense_Mutation_p.S739N|PPFIA4_ENST00000295706.4_Missense_Mutation_p.S255N			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	255					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						AGCAGCAACAGCAGCCAGGAC	0.582000													12	14					0	0	1	0	0
AGPAT9	84803	broad.mit.edu	37	4	84502845	84502845	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:84502845C>T	ENST00000395226.2	+	4	557	c.339C>T	c.(337-339)acC>acT	p.T113T	AGPAT9_ENST00000264409.4_Silent_p.T113T	NM_001256421.1	NP_001243350.1	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9	113					phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(3)	13		Hepatocellular(203;0.114)				ATGAAGTGACCCAGAGGTTTT	0.468000													59	102					0	0	1	0	0
IL17REL	400935	broad.mit.edu	37	22	50436618	50436618	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:50436618G>A	ENST00000389983.2	-	10	986	c.722C>T	c.(721-723)cCg>cTg	p.P241L	IL17REL_ENST00000341280.5_Missense_Mutation_p.P241L	NM_001001694.2	NP_001001694.2	Q6ZVW7	I17EL_HUMAN	interleukin 17 receptor E-like	241										endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		gccggcccccggccccgggcg	0.682000													47	51					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17228506	17228506	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:17228506G>A	ENST00000261381.6	-	9	1935	c.1851C>T	c.(1849-1851)taC>taT	p.Y617Y	CTD-2576D5.4_ENST00000567344.1_RNA	NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	617					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GGTAGTTCCCGTACAGGTAAT	0.572000													84	108					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55890694	55890694	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:55890694T>C	ENST00000313472.3	+	1	846	c.846T>C	c.(844-846)atT>atC	p.I282I		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					CTATTGTGATTCCCATGCTGA	0.368000													46	69					0	0	1	0	0
PLEKHA8	84725	broad.mit.edu	37	7	30085829	30085829	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:30085829A>G	ENST00000449726.1	+	3	511	c.161A>G	c.(160-162)cAt>cGt	p.H54R	PLEKHA8_ENST00000396257.2_Missense_Mutation_p.H54R|PLEKHA8_ENST00000396259.1_Missense_Mutation_p.H54R|PLEKHA8_ENST00000258679.7_Missense_Mutation_p.H54R|PLEKHA8_ENST00000483799.1_3'UTR	NM_001197027.1	NP_001183956.1	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8	54	PH.				protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	17						CTCCCAGTTCATTCTGTAGAT	0.512000													49	80					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7623913	7623913	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:7623913G>A	ENST00000221249.6	+	31	3892	c.3461G>A	c.(3460-3462)cGc>cAc	p.R1154H	PNPLA6_ENST00000600737.1_Missense_Mutation_p.R1192H|PNPLA6_ENST00000545201.2_Missense_Mutation_p.R1127H|PNPLA6_ENST00000414982.3_Missense_Mutation_p.R1202H|PNPLA6_ENST00000450331.3_Missense_Mutation_p.R1154H	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	1193					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						ATCCAGTCCCGCCTGGCCTAC	0.607000													31	40					0	0	1	0	0
LIN9	286826	broad.mit.edu	37	1	226453981	226453981	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:226453981C>A	ENST00000328205.5	-	9	1462	c.917G>T	c.(916-918)cGg>cTg	p.R306L	LIN9_ENST00000481685.1_Missense_Mutation_p.R271L|LIN9_ENST00000366801.1_Missense_Mutation_p.R255L	NM_173083.3	NP_775106.2	Q5TKA1	LIN9_HUMAN	lin-9 homolog (C. elegans)	290					cell cycle|DNA replication	nucleoplasm				breast(3)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		TCGAGAAGGCCGCTGTTTTTG	0.338000													15	11					0.000308642	0.000313286	1	1	0
NFAT5	10725	broad.mit.edu	37	16	69726657	69726657	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:69726657C>T	ENST00000349945.1	+	14	4199	c.2647C>T	c.(2647-2649)Cct>Tct	p.P883S	NFAT5_ENST00000393742.2_Missense_Mutation_p.P883S|NFAT5_ENST00000567239.1_Missense_Mutation_p.P976S|NFAT5_ENST00000354436.2_Missense_Mutation_p.P959S|NFAT5_ENST00000566899.1_Missense_Mutation_p.P883S|NFAT5_ENST00000432919.1_Missense_Mutation_p.P977S	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	959	Poly-Gln.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						TTCTTCTCCTCCTGCAGTTTC	0.448000													38	54					0	0	1	0	0
LRRC8A	56262	broad.mit.edu	37	9	131670971	131670971	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:131670971C>T	ENST00000259324.5	+	3	2051	c.1528C>T	c.(1528-1530)Ctg>Ttg	p.L510L	LRRC8A_ENST00000372600.4_Silent_p.L510L|LRRC8A_ENST00000372599.3_Silent_p.L510L	NM_001127244.1	NP_001120716.1	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member A	510					pre-B cell differentiation	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						GGAGATCCCGCTGTGGATCTA	0.612000													24	28					0	0	1	0	0
PITPNM1	9600	broad.mit.edu	37	11	67261432	67261432	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:67261432G>A	ENST00000356404.3	-	20	3194	c.2969C>T	c.(2968-2970)gCg>gTg	p.A990V	PITPNM1_ENST00000534749.1_Missense_Mutation_p.A990V|PITPNM1_ENST00000436757.2_Missense_Mutation_p.A989V|PITPNM1_ENST00000526450.1_5'UTR	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	990					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						AATGCCCAGCGCGCGTTCTGG	0.682000													28	21					0	0	1	0	0
PTPRM	5797	broad.mit.edu	37	18	8114820	8114820	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:8114820C>T	ENST00000332175.8	+	13	3199	c.2162C>T	c.(2161-2163)aCa>aTa	p.T721I	PTPRM_ENST00000400053.4_Missense_Mutation_p.T659I|PTPRM_ENST00000444013.1_Missense_Mutation_p.T508I|PTPRM_ENST00000400060.4_Missense_Mutation_p.T721I|PTPRM_ENST00000580170.1_Missense_Mutation_p.T721I	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	721					homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				CAAGTGGCCACAAAAGGTAGG	0.299000													19	15					0	0	1	0	0
DBNL	28988	broad.mit.edu	37	7	44098476	44098476	+	Splice_Site	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:44098476G>T	ENST00000468694.1	+	9	783		c.e9-1		DBNL_ENST00000497184.1_Intron|DBNL_ENST00000452943.1_Intron|DBNL_ENST00000456905.1_Intron|DBNL_ENST00000440166.1_Intron|DBNL_ENST00000490734.2_Intron|DBNL_ENST00000448521.1_Intron|DBNL_ENST00000494774.1_Intron	NM_001122956.1	NP_001116428.1	Q9UJU6	DBNL_HUMAN	drebrin-like						activation of JUN kinase activity|cellular component disassembly involved in apoptosis|endocytosis|Rac protein signal transduction	cell cortex|cytoskeleton|cytosol|lamellipodium	actin binding|enzyme activator activity|identical protein binding			breast(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|stomach(1)	12						GCCCACTGCAGGGGTCAACAT	0.602000													22	20					8.10497e-08	8.47206e-08	1	1	0
LPAL2	0	broad.mit.edu	37	6	160905191	160905191	+	RNA	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:160905191T>C	ENST00000335388.5	-	0	936					NR_028092.1															large_intestine(1)|lung(4)	5		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		CAGGTTGCAGTACTCCCATCT	0.502000													79	49					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51217078	51217078	+	Missense_Mutation	SNP	C	C	T	rs138468869		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:51217078C>T	ENST00000293441.1	-	5	787	c.769G>A	c.(769-771)Gcc>Acc	p.A257T	SHANK1_ENST00000391814.1_Missense_Mutation_p.A257T|SHANK1_ENST00000359082.3_Missense_Mutation_p.A257T	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	257					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CAGTGTCGGGCGCATGCGGCC	0.627000													42	56					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	192053197	192053197	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:192053197C>T	ENST00000454309.2	-	3	1192	c.367G>A	c.(367-369)Gct>Act	p.A123T	FGF12_ENST00000264730.3_Missense_Mutation_p.A61T|FGF12_ENST00000445105.1_Missense_Mutation_p.A61T|FGF12_ENST00000450716.1_Missense_Mutation_p.A61T|FGF12_ENST00000430714.1_Missense_Mutation_p.A24T	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	123					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		TAGAGGCTAGCCTTCACTCCT	0.478000													15	36					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18378026	18378026	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:18378026C>T	ENST00000392413.3	-	3	539	c.324G>A	c.(322-324)acG>acA	p.T108T	KIAA1683_ENST00000600328.2_Silent_p.T108T|KIAA1683_ENST00000600359.2_Silent_p.T62T	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	108	IQ 1.					mitochondrion		p.T108T(1)		breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						CTTGGATGAGCGTGGCTGCAC	0.637000													56	70					0	0	1	0	0
CCNB3	85417	broad.mit.edu	37	X	50085296	50085296	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:50085296A>G	ENST00000376042.1	+	9	3910	c.3612A>G	c.(3610-3612)caA>caG	p.Q1204Q	CCNB3_ENST00000348603.2_Silent_p.Q100Q|CCNB3_ENST00000376038.1_Silent_p.Q100Q|CCNB3_ENST00000276014.7_Silent_p.Q1204Q			Q8WWL7	CCNB3_HUMAN	cyclin B3	1204					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					ATAAGTTACAACTCCTTGGTG	0.468000													43	62					0	0	1	0	0
MYD88	4615	broad.mit.edu	37	3	38182689	38182689	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:38182689T>C	ENST00000417037.2	+	5	1050	c.866T>C	c.(865-867)cTg>cCg	p.L289P	MYD88_ENST00000443433.2_3'UTR|MYD88_ENST00000481122.1_3'UTR|MYD88_ENST00000424893.1_Missense_Mutation_p.L236P|MYD88_ENST00000396334.3_Missense_Mutation_p.L281P|MYD88_ENST00000495303.1_3'UTR	NM_001172567.1	NP_001166038.1	Q99836	MYD88_HUMAN	myeloid differentiation primary response 88	268	TIR.				3'-UTR-mediated mRNA stabilization|anti-apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-17 production|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|regulation of inflammatory response|response to interleukin-1|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|intrinsic to membrane|plasma membrane	death receptor binding|TIR domain binding|transmembrane receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(226)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	237				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CCCAGCATCCTGAGGTTCATC	0.552000			Mis		ABC-DLBCL								61	80					0	0	1	0	0
HPS5	11234	broad.mit.edu	37	11	18301454	18301454	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:18301454C>T	ENST00000396253.3	-	22	3485	c.3023G>A	c.(3022-3024)cGg>cAg	p.R1008Q	HPS5_ENST00000537258.1_3'UTR|HPS5_ENST00000438420.2_Missense_Mutation_p.R1008Q|HPS5_ENST00000349215.3_Missense_Mutation_p.R1122Q	NM_007216.3	NP_009147.3	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5	1122						cytosol				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						CCAGAGAAACCGATCGCATTT	0.403000									Hermansky-Pudlak syndrome				20	34					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900216	151900216	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:151900216G>A	ENST00000393900.3	-	3	938	c.585C>T	c.(583-585)atC>atT	p.I195I	MAGEA12_ENST00000393869.3_Silent_p.I195I|CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000357916.4_Silent_p.I195I	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	195	MAGE.							p.I195I(1)		breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					TCTTGGGCACGATCTGATTGT	0.577000													99	136					0	0	1	0	0
SLC9A3	6550	broad.mit.edu	37	5	476346	476346	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:476346G>A	ENST00000264938.3	-	13	2047	c.2038C>T	c.(2038-2040)Ctg>Ttg	p.L680L	CTD-2228K2.7_ENST00000606319.1_RNA|SLC9A3_ENST00000514375.1_Silent_p.L671L|CTD-2228K2.7_ENST00000607286.1_RNA	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	680						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CGCTTGTACAGCTTGGCCGCC	0.647000													18	46					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767907	57767907	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:57767907G>A	ENST00000371030.2	+	1	1833	c.1833G>A	c.(1831-1833)agG>agA	p.R611R		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	611						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GCCAGAGAAGGCTGAAGATGT	0.597000													46	141					0	0	1	0	0
WWC1	23286	broad.mit.edu	37	5	167882440	167882440	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:167882440C>T	ENST00000265293.4	+	19	3240	c.2738C>T	c.(2737-2739)cCg>cTg	p.P913L	WWC1_ENST00000521089.1_Missense_Mutation_p.P913L|WWC1_ENST00000522140.1_3'UTR	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	913	Interaction with histone H3.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		GTGGGCACCCCGTCCCAGGGG	0.622000													129	105					0	0	1	0	0
TNPO2	30000	broad.mit.edu	37	19	12825886	12825886	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:12825886A>G	ENST00000425528.1	-	9	1103	c.746T>C	c.(745-747)aTc>aCc	p.I249T	TNPO2_ENST00000592287.1_Missense_Mutation_p.I249T|TNPO2_ENST00000441499.1_Missense_Mutation_p.I249T|TNPO2_ENST00000588216.1_Missense_Mutation_p.I249T|TNPO2_ENST00000356861.5_Missense_Mutation_p.I249T|TNPO2_ENST00000450764.2_Missense_Mutation_p.I249T|TNPO2_ENST00000589956.1_Intron			O14787	TNPO2_HUMAN	transportin 2	249					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CATGTGGGGGATGAGCCTGTC	0.642000													37	43					0	0	1	0	0
SNX2	6643	broad.mit.edu	37	5	122165305	122165305	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:122165305T>C	ENST00000379516.2	+	15	1630	c.1522T>C	c.(1522-1524)Tgg>Cgg	p.W508R	SNX2_ENST00000510372.1_3'UTR|SNX2_ENST00000514949.1_Missense_Mutation_p.W391R	NM_003100.2	NP_003091.2	O60749	SNX2_HUMAN	sorting nexin 2	508					cell communication|endocytosis|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)|skin(1)	19		all_cancers(142;1.14e-44)|all_lung(232;1.03e-13)|Lung NSC(810;2.5e-13)|Breast(839;0.000812)|Myeloproliferative disorder(839;0.0122)|Prostate(80;0.0235)|all_hematologic(541;0.0592)|all_neural(839;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	all cancers(49;2.13e-24)|Epithelial(69;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(64;5.6e-11)|BRCA - Breast invasive adenocarcinoma(61;0.00013)|GBM - Glioblastoma multiforme(465;0.000357)|COAD - Colon adenocarcinoma(49;0.000887)|Lung(113;0.0109)		GATAAAATACTGGGAAGCATT	0.343000													21	50					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128792	45128792	+	RNA	SNP	G	G	T	rs143713325	by1000genomes	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:45128792G>T	ENST00000575173.1	-	0	418																											AATTCAGGTTGTCAGAATGCA	0.373000													4	31					0.00024832	0.000252935	1	1	0
ARMCX2	9823	broad.mit.edu	37	X	100911796	100911796	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:100911796G>A	ENST00000328766.5	-	5	1232	c.779C>T	c.(778-780)aCc>aTc	p.T260I	ARMCX2_ENST00000330154.2_Missense_Mutation_p.T260I|ARMCX2_ENST00000356824.4_Missense_Mutation_p.T260I	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	260	Ala-rich.					integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						AGCCCCAGGGGTTGCTTTCTT	0.602000													47	102					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63547798	63547798	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:63547798G>A	ENST00000397968.2	+	12	2452	c.2026G>A	c.(2026-2028)Gtc>Atc	p.V676I	CDH7_ENST00000323011.3_Missense_Mutation_p.V676I	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	676					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				AAACCTCAACGTCATCCGAGA	0.483000													36	46					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102506038	102506038	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:102506038C>T	ENST00000360184.4	+	62	11823	c.11659C>T	c.(11659-11661)Ctg>Ttg	p.L3887L	RP11-1017G21.4_ENST00000557551.1_RNA|RP11-1017G21.4_ENST00000553701.1_RNA|RP11-1017G21.4_ENST00000557242.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3887					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TGCCATGCTGCTGGCAAGAAT	0.537000													62	67					0	0	1	0	0
ST5	6764	broad.mit.edu	37	11	8720914	8720914	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:8720914G>A	ENST00000534127.1	-	18	3129	c.2744C>T	c.(2743-2745)gCg>gTg	p.A915V	ST5_ENST00000526099.1_Missense_Mutation_p.A428V|ST5_ENST00000526757.1_Missense_Mutation_p.A495V|ST5_ENST00000534278.1_Missense_Mutation_p.A106V|ST5_ENST00000530438.1_Missense_Mutation_p.A495V|RPL27A_ENST00000531102.1_Intron|ST5_ENST00000313726.6_Missense_Mutation_p.A915V|ST5_ENST00000357665.1_Missense_Mutation_p.A915V|ST5_ENST00000530991.1_Missense_Mutation_p.A387V	NM_005418.3	NP_005409.3	P78524	ST5_HUMAN	suppression of tumorigenicity 5	915	DENN.				positive regulation of ERK1 and ERK2 cascade		protein binding			NS(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(13)|liver(1)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	39				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		GGCCACCACCGCGTGGGAGCA	0.617000													30	23					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72297544	72297544	+	RNA	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:72297544C>A	ENST00000438125.1	-	0	123							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										GAGGAGAGGTCCCATGTATCC	0.343000													16	36					4.7546e-09	5.0178e-09	1	1	0
SLC41A2	84102	broad.mit.edu	37	12	105282851	105282851	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:105282851A>G	ENST00000258538.3	-	4	967	c.840T>C	c.(838-840)tcT>tcC	p.S280S		NM_032148.3	NP_115524.3	Q96JW4	S41A2_HUMAN	solute carrier family 41 (magnesium transporter), member 2	280						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	22						CCACACTGCTAGAGCACAGAA	0.388000													45	56					0	0	1	0	0
ASIC2	40	broad.mit.edu	37	17	32483140	32483140	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:32483140G>A	ENST00000359872.6	-	1	1173	c.412C>T	c.(412-414)Cgg>Tgg	p.R138W		NM_001094.4	NP_001085.2	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	138					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding	p.R138W(1)								Amiloride(DB00594)	GCCTTCTGCCGCAGGGCCTCC	0.592000													50	73					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128843210	128843210	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:128843210G>A	ENST00000310343.9	-	21	3148	c.3149C>T	c.(3148-3150)tCc>tTc	p.S1050F	ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.S701F|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.S701F	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1050					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						TTGCTGTGCGGACTCAGCTAA	0.512000													79	114					0	0	1	0	0
SLC12A6	9990	broad.mit.edu	37	15	34546772	34546772	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:34546772C>A	ENST00000354181.3	-	9	1387	c.895G>T	c.(895-897)Gct>Tct	p.A299S	SLC12A6_ENST00000451844.2_Missense_Mutation_p.A111S|SLC12A6_ENST00000560164.1_Missense_Mutation_p.A111S|SLC12A6_ENST00000558589.1_Missense_Mutation_p.A290S|SLC12A6_ENST00000290209.5_Missense_Mutation_p.A248S|SLC12A6_ENST00000397707.2_Missense_Mutation_p.A284S|SLC12A6_ENST00000458406.2_Missense_Mutation_p.A240S|SLC12A6_ENST00000560611.1_Missense_Mutation_p.A299S|SLC12A6_ENST00000397702.2_Missense_Mutation_p.A240S|SLC12A6_ENST00000558667.1_Missense_Mutation_p.A299S			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	299					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	AAGATGGCAGCTCGGGGGACG	0.388000													31	52					1.06801e-11	1.13671e-11	1	1	0
HBP1	26959	broad.mit.edu	37	7	106826902	106826902	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:106826902C>T	ENST00000222574.4	+	5	823	c.637C>T	c.(637-639)Cac>Tac	p.H213Y	HBP1_ENST00000468410.1_Missense_Mutation_p.H213Y|HBP1_ENST00000485846.1_Missense_Mutation_p.H213Y	NM_012257.3	NP_036389.2	O60381	HBP1_HUMAN	HMG-box transcription factor 1	213	AXH.				cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			large_intestine(4)|lung(3)|prostate(1)|skin(2)	10						AACTGTCTGGCACTGTTTTTT	0.398000													53	84					0	0	1	0	0
BMP15	9210	broad.mit.edu	37	X	50659512	50659512	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:50659512T>C	ENST00000252677.3	+	2	1084	c.1084T>C	c.(1084-1086)Tat>Cat	p.Y362H		NM_005448.2	NP_005439.2	O95972	BMP15_HUMAN	bone morphogenetic protein 15	362					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(1)	26	Ovarian(276;0.236)					CCCGTATAAGTATGTTCCAAT	0.463000													45	60					0	0	1	0	0
MAGEL2	54551	broad.mit.edu	37	15	23889906	23889906	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:23889906T>C	ENST00000532292.1	-	1	1269	c.1175A>G	c.(1174-1176)gAg>gGg	p.E392G		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		ACTTGCGACCTCAGACACAAC	0.622000													24	20					0	0	1	0	0
CCDC70	83446	broad.mit.edu	37	13	52439515	52439515	+	Translation_Start_Site	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:52439515A>G	ENST00000242819.4	+	2	297	c.1A>G	c.(1-3)Atg>Gtg	p.M1V		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	1						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		GTCATCCCTCATGGCCACCCC	0.597000													31	21					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47728788	47728788	+	Splice_Site	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:47728788G>A	ENST00000371877.3	-	15	2763	c.2615_splice	c.e15-1	p.N872_splice	STIL_ENST00000396221.2_Intron|STIL_ENST00000360380.3_Intron|STIL_ENST00000337817.5_Intron|STIL_ENST00000243182.6_Intron			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	872					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				GAGAAGAGCTGCTGGGAAGGA	0.398000													11	18					0	0	1	0	0
GFPT1	2673	broad.mit.edu	37	2	69554051	69554051	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:69554051A>G	ENST00000357308.4	-	19	2228	c.2050T>C	c.(2050-2052)Tat>Cat	p.Y684H	GFPT1_ENST00000361060.4_Missense_Mutation_p.Y666H	NM_001244710.1	NP_001231639.1	Q06210	GFPT1_HUMAN	glutamine--fructose-6-phosphate transaminase 1	684	SIS 2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			endometrium(1)|large_intestine(3)|lung(5)|skin(3)	12						CTTACATCATAGCCTCTCAGC	0.433000													25	22					0	0	1	0	0
VPS52	6293	broad.mit.edu	37	6	33231322	33231322	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:33231322C>T	ENST00000445902.2	-	17	1951	c.1733G>A	c.(1732-1734)cGg>cAg	p.R578Q	VPS52_ENST00000482399.1_3'UTR|VPS52_ENST00000436044.2_Missense_Mutation_p.R453Q|VPS52_ENST00000478934.1_5'UTR	NM_022553.4	NP_072047.4	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52 homolog (S. cerevisiae)	578					protein transport	endosome membrane|Golgi apparatus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(8)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28						ATCTGCAGCCCGCTCCTAAGG	0.512000													26	35					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6703716	6703716	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:6703716C>T	ENST00000309577.6	-	15	2385	c.2222G>A	c.(2221-2223)tGg>tAg	p.W741*	CHD4_ENST00000357008.2_Nonsense_Mutation_p.W741*|CHD4_ENST00000544484.1_Nonsense_Mutation_p.W738*|CHD4_ENST00000544040.1_Nonsense_Mutation_p.W734*			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	741	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GCCCTGAGCCCAGGAGAAGCG	0.522000													43	56					0	0	1	0	0
IFNW1	3467	broad.mit.edu	37	9	21141170	21141170	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:21141170C>T	ENST00000380229.2	-	1	974	c.400G>A	c.(400-402)Ggg>Agg	p.G134R		NM_002177.1	NP_002168.1	P05000	IFNW1_HUMAN	interferon, omega 1	134					cell cycle arrest|defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|kidney(1)|lung(2)|ovary(1)	5				GBM - Glioblastoma multiforme(5;2.35e-185)|Lung(24;2.24e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CTAATTGCCCCAGCAGATTCT	0.527000													33	44					0	0	1	0	0
DBH	1621	broad.mit.edu	37	9	136508685	136508685	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:136508685C>A	ENST00000393056.2	+	4	907	c.895C>A	c.(895-897)Ctg>Atg	p.L299M		NM_000787.3	NP_000778.3	P09172	DOPO_HUMAN	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	299					hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	36				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CCGCCACGTGCTGGCCGCCTG	0.682000													33	56					6.86731e-36	7.72132e-36	1	1	0
TTYH3	80727	broad.mit.edu	37	7	2687615	2687615	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:2687615C>T	ENST00000258796.7	+	5	854	c.649C>T	c.(649-651)Ctg>Ttg	p.L217L	TTYH3_ENST00000403167.1_Silent_p.L46L|TTYH3_ENST00000407643.1_Intron|TTYH3_ENST00000477439.1_3'UTR	NM_025250.2	NP_079526.1	Q9C0H2	TTYH3_HUMAN	tweety family member 3	217						chloride channel complex|plasma membrane	chloride channel activity			kidney(1)|large_intestine(3)|lung(9)|prostate(2)|upper_aerodigestive_tract(2)	17		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		CCTGGGCCTGCTGCTGCTGGA	0.706000													7	91					0	0	1	0	0
UVSSA	57654	broad.mit.edu	37	4	1360206	1360206	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:1360206G>A	ENST00000389851.4	+	8	1722	c.1275G>A	c.(1273-1275)ttG>ttA	p.L425L	UVSSA_ENST00000511563.1_5'UTR|UVSSA_ENST00000511216.1_Silent_p.L425L|UVSSA_ENST00000507531.1_Silent_p.L425L	NM_020894.2	NP_065945.2	Q2YD98	K1530_HUMAN	UV-stimulated scaffold protein A	425																	CCGACCACTTGCGGCCTGAGT	0.637000													68	99					0	0	1	0	0
MSTO1	55154	broad.mit.edu	37	1	155717654	155717654	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:155717654T>C	ENST00000452804.2	+	7	922	c.861T>C	c.(859-861)acT>acC	p.T287T				Q9BUK6	MSTO1_HUMAN	misato 1, mitochondrial distribution and morphology regulator	260					mitochondrion distribution|protein polymerization	mitochondrial outer membrane|protein complex				breast(2)|endometrium(1)|lung(3)|skin(1)	7	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)					GAATAATAACTTGGGGCCTGC	0.532000													18	57					0	0	1	0	0
BCL3	602	broad.mit.edu	37	19	45260667	45260667	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:45260667G>A	ENST00000164227.5	+	5	1052	c.808G>A	c.(808-810)Gca>Aca	p.A270T		NM_005178.4	NP_005169.2	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	270					DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				CGACATCGACGCAGTGGTGAG	0.692000			T	IGH@	CLL								3	8					0	0	1	0	0
SLC20A2	6575	broad.mit.edu	37	8	42275398	42275398	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:42275398C>T	ENST00000342228.3	-	11	2251	c.1882G>A	c.(1882-1884)Gtg>Atg	p.V628M	SLC20A2_ENST00000520179.1_Missense_Mutation_p.V628M|SLC20A2_ENST00000520262.1_Missense_Mutation_p.V628M	NM_006749.4	NP_006740.1	Q08357	S20A2_HUMAN	solute carrier family 20 (phosphate transporter), member 2	628					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GGGACGGTCACGAACCAGGCC	0.592000													79	64					0	0	1	0	0
BMP1	649	broad.mit.edu	37	8	22034617	22034617	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:22034617G>A	ENST00000306385.5	+	5	1365	c.695G>A	c.(694-696)cGc>cAc	p.R232H	BMP1_ENST00000397816.3_Missense_Mutation_p.R232H|BMP1_ENST00000397814.3_Missense_Mutation_p.R232H|BMP1_ENST00000306349.8_Missense_Mutation_p.R232H|BMP1_ENST00000354870.5_Missense_Mutation_p.R232H	NM_006129.4	NP_006120.1	P13497	BMP1_HUMAN	bone morphogenetic protein 1	232	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GACCGGGACCGCCACGTTTCC	0.647000													7	28					0	0	1	0	0
TEX10	54881	broad.mit.edu	37	9	103108398	103108398	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:103108398G>T	ENST00000374902.4	-	4	1269	c.1093C>A	c.(1093-1095)Ctt>Att	p.L365I	TEX10_ENST00000535814.1_Missense_Mutation_p.L368I|TEX10_ENST00000537512.1_Missense_Mutation_p.L300I	NM_017746.3	NP_060216.2	Q9NXF1	TEX10_HUMAN	testis expressed 10	365						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TTCCACAGAAGGGAAATAATA	0.373000													9	39					1.76689e-08	1.85133e-08	1	1	0
KREMEN2	79412	broad.mit.edu	37	16	3016379	3016379	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:3016379G>A	ENST00000572045.1	+	4	720	c.415G>A	c.(415-417)Ggc>Agc	p.G139S	KREMEN2_ENST00000575769.1_Missense_Mutation_p.G139S|KREMEN2_ENST00000575885.1_Missense_Mutation_p.G139S|KREMEN2_ENST00000319500.6_Missense_Mutation_p.G139S|KREMEN2_ENST00000571007.1_Missense_Mutation_p.G139S|KREMEN2_ENST00000303746.5_Missense_Mutation_p.G139S	NM_172229.2	NP_757384.1	Q8NCW0	KREM2_HUMAN	kringle containing transmembrane protein 2	139	WSC.				Wnt receptor signaling pathway	integral to membrane				central_nervous_system(2)|endometrium(1)|large_intestine(1)	4						AGCCCTCAGCGGCCCCAGCGG	0.642000													60	96					0	0	1	0	0
MAPRE2	10982	broad.mit.edu	37	18	32720278	32720278	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:32720278C>T	ENST00000436190.2	+	8	1167	c.893C>T	c.(892-894)cCg>cTg	p.P298L	MAPRE2_ENST00000538170.2_Missense_Mutation_p.P257L|MAPRE2_ENST00000589699.1_Missense_Mutation_p.P267L|MAPRE2_ENST00000300249.5_Missense_Mutation_p.P310L|MAPRE2_ENST00000413393.1_Missense_Mutation_p.P267L	NM_001143827.2	NP_001137299.1	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family, member 2	310	APC-binding.|DCTN1-binding.|EB1 C-terminal.				cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	9						ACAGAAGAGCCGGAAGCAGAG	0.597000													9	16					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133923762	133923762	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:133923762T>C	ENST00000220616.4	+	19	4183	c.4143T>C	c.(4141-4143)ccT>ccC	p.P1381P	TG_ENST00000377869.1_Silent_p.P1381P	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1381					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTTCTCTTCCTGACTTACATG	0.473000													57	148					0	0	1	0	0
HJURP	55355	broad.mit.edu	37	2	234750399	234750399	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:234750399C>T	ENST00000411486.2	-	8	1092	c.1027G>A	c.(1027-1029)Gta>Ata	p.V343I	HJURP_ENST00000441687.1_Missense_Mutation_p.V258I|HJURP_ENST00000432087.1_Missense_Mutation_p.V289I	NM_018410.3	NP_060880.3	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	343					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			NS(2)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(2)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		ACATCTAATACGTTCTTGCAA	0.438000													20	23					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11725897	11725897	+	Missense_Mutation	SNP	A	A	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:11725897A>C	ENST00000262442.3	+	47	9061	c.8993A>C	c.(8992-8994)cAg>cCg	p.Q2998P	DNAH9_ENST00000454412.2_Missense_Mutation_p.Q2998P	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2998	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CGCTTCTTGCAGAACACAGAG	0.522000													68	92					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62839359	62839359	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:62839359G>A	ENST00000536311.1	+	7	1174	c.810G>A	c.(808-810)gaG>gaA	p.E270E	MYT1_ENST00000328439.1_Silent_p.E270E|MYT1_ENST00000360149.4_Intron			Q01538	MYT1_HUMAN	myelin transcription factor 1	270	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					aggaagaggaggaggaggagg	0.577000													15	21					0	0	1	0	0
PADI6	353238	broad.mit.edu	37	1	17727969	17727969	+	RNA	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:17727969G>A	ENST00000434762.2	+	0	2171							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	CTGCCCCAGCGTGGATGGCCC	0.587000													3	21					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24831988	24831988	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:24831988G>A	ENST00000376451.2	+	14	3098	c.2838G>A	c.(2836-2838)gtG>gtA	p.V946V	KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000396446.1_Intron|KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000376454.3_Silent_p.V1263V			Q5T5P2	SKT_HUMAN	KIAA1217	1263					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						AGGAAACTGTGCCTAAGGCCA	0.383000													36	29					0	0	1	0	0
ZFYVE19	84936	broad.mit.edu	37	15	41099853	41099853	+	Silent	SNP	C	C	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:41099853C>G	ENST00000355341.4	+	1	567	c.66C>G	c.(64-66)tcC>tcG	p.S22S	ZFYVE19_ENST00000564258.1_5'UTR|ZFYVE19_ENST00000570108.1_Intron|ZFYVE19_ENST00000299173.10_Silent_p.S22S|ZFYVE19_ENST00000336455.5_Intron	NM_001077268.1	NP_001070736.1	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	22							zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	9		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GGAGAGCGTCCGGATTCCCTG	0.692000													11	16					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	112998226	112998226	+	Missense_Mutation	SNP	A	A	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:112998226A>C	ENST00000495514.1	+	12	2648	c.1944A>C	c.(1942-1944)aaA>aaC	p.K648N	BOC_ENST00000273395.4_Missense_Mutation_p.K649N|BOC_ENST00000355385.3_Missense_Mutation_p.K648N			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	648	Fibronectin type-III 2.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			AGCTAAAGAAAGTGGGAGACT	0.612000													33	54					0	0	1	0	0
DHRS12	79758	broad.mit.edu	37	13	52365373	52365373	+	Silent	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:52365373C>A	ENST00000218981.1	-	3	258	c.147G>T	c.(145-147)gtG>gtT	p.V49V	DHRS12_ENST00000490949.1_5'UTR|DHRS12_ENST00000280056.2_Silent_p.V49V|DHRS12_ENST00000444610.2_Silent_p.V98V	NM_024705.2	NP_078981.1	A0PJE2	DHR12_HUMAN	dehydrogenase/reductase (SDR family) member 12	98							binding|oxidoreductase activity			cervix(1)|large_intestine(1)|lung(2)|skin(2)|urinary_tract(1)	7		Breast(56;0.00173)|Prostate(109;0.00899)|Lung NSC(96;0.0199)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.81e-08)		CAGACAAGTCCACAATGTGCA	0.299000													8	22					0.0477658	0.0479846	1	1	0
POMT1	10585	broad.mit.edu	37	9	134382768	134382768	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:134382768C>T	ENST00000423007.1	+	5	736	c.294C>T	c.(292-294)aaC>aaT	p.N98N	POMT1_ENST00000419118.2_Intron|POMT1_ENST00000402686.3_Silent_p.N98N|POMT1_ENST00000372228.3_Silent_p.N98N|POMT1_ENST00000354713.4_Silent_p.N68N|POMT1_ENST00000404875.2_5'UTR|POMT1_ENST00000341012.7_Silent_p.N44N|POMT1_ENST00000541219.1_Intron	NM_001136113.1	NP_001129585.1	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1	98					multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	31		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		ACAGTAGCAACGTGCCTGTGT	0.557000													54	80					0	0	1	0	0
SEC31A	22872	broad.mit.edu	37	4	83788042	83788042	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:83788042C>T	ENST00000432794.1	-	10	1279	c.1116G>A	c.(1114-1116)caG>caA	p.Q372Q	SEC31A_ENST00000436790.2_5'UTR|SEC31A_ENST00000508479.1_Silent_p.Q372Q|SEC31A_ENST00000311785.7_Silent_p.Q372Q|SEC31A_ENST00000513858.1_Silent_p.Q372Q|SEC31A_ENST00000505472.1_Silent_p.Q372Q|SEC31A_ENST00000509142.1_Silent_p.Q372Q|SEC31A_ENST00000508502.1_Silent_p.Q372Q|SEC31A_ENST00000505984.1_Silent_p.Q372Q|SEC31A_ENST00000264405.5_Silent_p.Q144Q|SEC31A_ENST00000448323.1_Silent_p.Q372Q|SEC31A_ENST00000443462.2_Silent_p.Q367Q|SEC31A_ENST00000395310.2_Silent_p.Q372Q|SEC31A_ENST00000355196.2_Silent_p.Q372Q|SEC31A_ENST00000348405.4_Silent_p.Q372Q|SEC31A_ENST00000500777.2_Silent_p.Q372Q|SEC31A_ENST00000326950.5_Silent_p.Q372Q			O94979	SC31A_HUMAN	SEC31 homolog A (S. cerevisiae)	372	Interaction with SEC13.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/ALK(3)|SEC31A/JAK2(4)	breast(1)	1		Hepatocellular(203;0.114)				GAGCAGTCTGCTGTGGAATTT	0.433000													70	95					0	0	1	0	0
GRAMD1A	57655	broad.mit.edu	37	19	35500223	35500223	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:35500223G>A	ENST00000599564.1	+	3	541	c.470G>A	c.(469-471)cGc>cAc	p.R157H	GRAMD1A_ENST00000598073.1_3'UTR|GRAMD1A_ENST00000317991.5_Missense_Mutation_p.R70H|GRAMD1A_ENST00000411896.2_Missense_Mutation_p.R70H|GRAMD1A_ENST00000504615.2_5'UTR|GRAMD1A_ENST00000424536.2_Missense_Mutation_p.R70H			Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A	70	GRAM.					integral to membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	19	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			AACTTCATCCGCAACAGCAAG	0.622000													36	56					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102372596	102372596	+	Splice_Site	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:102372596T>C	ENST00000369138.1	+	12	2357		c.e12+2		GRIK2_ENST00000369137.3_Intron|GRIK2_ENST00000369134.4_Splice_Site|GRIK2_ENST00000318991.6_Splice_Site|GRIK2_ENST00000421544.1_Splice_Site|GRIK2_ENST00000413795.1_Splice_Site	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2						glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TGCAGCAAGGTATACGATTCA	0.498000													16	45					0	0	1	0	0
C15orf39	56905	broad.mit.edu	37	15	75498963	75498963	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:75498963C>T	ENST00000360639.2	+	2	894	c.574C>T	c.(574-576)Cgg>Tgg	p.R192W	C15orf39_ENST00000567617.1_Missense_Mutation_p.R192W|C15orf39_ENST00000394987.4_Missense_Mutation_p.R192W			Q6ZRI6	CO039_HUMAN	chromosome 15 open reading frame 39	192										autonomic_ganglia(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16						CACCTTCTTGCGGGGGGTGCC	0.627000													48	62					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1046869	1046869	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:1046869T>C	ENST00000263094.6	+	14	1922	c.1691T>C	c.(1690-1692)cTg>cCg	p.L564P	ABCA7_ENST00000435683.2_Missense_Mutation_p.L426P|ABCA7_ENST00000433129.1_Missense_Mutation_p.L564P|ABCA7_ENST00000533574.1_Intron	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	564					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGTGACACTGACAGTGAAG	0.687000													4	2					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112824031	112824031	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:112824031G>A	ENST00000408903.3	-	1	496	c.81C>T	c.(79-81)agC>agT	p.S27S		NM_001085377.1	NP_001078846.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	555					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		TGTcgctgctgctgctgctgc	0.741000													24	10					0	0	1	0	0
CD36	948	broad.mit.edu	37	7	80276069	80276069	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:80276069C>T	ENST00000435819.1	+	6	697	c.13C>T	c.(13-15)Cgg>Tgg	p.R5W	CD36_ENST00000441109.2_3'UTR|CD36_ENST00000447544.2_Missense_Mutation_p.R5W|CD36_ENST00000544133.1_Missense_Mutation_p.R5W|CD36_ENST00000432207.1_Missense_Mutation_p.R5W|CD36_ENST00000394788.3_Missense_Mutation_p.R5W|CD36_ENST00000534394.1_Intron|CD36_ENST00000309881.7_Missense_Mutation_p.R5W|CD36_ENST00000538969.1_Missense_Mutation_p.R5W|CD36_ENST00000433696.2_Missense_Mutation_p.R5W			P16671	CD36_HUMAN	CD36 molecule (thrombospondin receptor)	5					cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|large_intestine(1)|lung(6)|ovary(1)	21						GGGCTGTGACCGGAACTGTGG	0.468000													50	53					0	0	1	0	0
SF3B1	23451	broad.mit.edu	37	2	198274672	198274672	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:198274672G>A	ENST00000335508.5	-	7	817	c.726C>T	c.(724-726)agC>agT	p.S242S		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	242	Interaction with PPP1R8.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CAGGAGTCTCGCTTCCCTTTG	0.512000			Mis		myelodysplastic syndrome								37	54					0	0	1	0	0
ZC3H11A	9877	broad.mit.edu	37	1	203819736	203819736	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:203819736C>T	ENST00000545588.1	+	15	5860	c.2033C>T	c.(2032-2034)gCt>gTt	p.A678V	ZC3H11A_ENST00000367210.1_Missense_Mutation_p.A678V|ZC3H11A_ENST00000367212.3_Missense_Mutation_p.A678V|ZC3H11A_ENST00000332127.4_Missense_Mutation_p.A678V|ZC3H11A_ENST00000367214.1_Missense_Mutation_p.A678V	NM_001271675.1	NP_001258604.1	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	678							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			ATGCACGCTGCTGTCATTGCC	0.502000													29	40					0	0	1	0	0
MIR7-3HG	0	broad.mit.edu	37	19	4770703	4770703	+	RNA	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:4770703A>G	ENST00000586721.1	+	0	509				MIR7-3_ENST00000384898.1_RNA																							GCTGTGGTCTAGTGCTGTGTG	0.532000													83	149					0	0	1	0	0
ZYX	7791	broad.mit.edu	37	7	143087016	143087016	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:143087016T>C	ENST00000322764.5	+	9	1905	c.1560T>C	c.(1558-1560)acT>acC	p.T520T	ZYX_ENST00000392910.2_Silent_p.T363T|ZYX_ENST00000449423.2_Silent_p.T433T	NM_001010972.1|NM_003461.4	NP_001010972.1|NP_003452.1	Q15942	ZYX_HUMAN	zyxin	520	LIM zinc-binding 3.				cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)	17	Melanoma(164;0.205)					GAGATGAGACTGTGCGAGTGG	0.602000													37	42					0	0	1	0	0
FOCAD	54914	broad.mit.edu	37	9	20758097	20758097	+	Missense_Mutation	SNP	C	C	A	rs143814736	by1000genomes	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:20758097C>A	ENST00000380249.1	+	8	765	c.401C>A	c.(400-402)cCt>cAt	p.P134H	FOCAD_ENST00000338382.6_Missense_Mutation_p.P134H	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	134						integral to membrane	binding										AGAAATCATCCTCATCCTTTG	0.433000													16	22					1.15088e-07	1.20157e-07	1	1	0
AGXT	189	broad.mit.edu	37	2	241808756	241808756	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:241808756C>T	ENST00000307503.3	+	2	722	c.335C>T	c.(334-336)gCc>gTc	p.A112V		NM_000030.2	NP_000021.1	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	112			A -> D (in HP1).		glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)	18		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GGGCAGCGAGCCGTGGACATC	0.647000													41	41					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39963560	39963560	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:39963560C>T	ENST00000599117.1	+	23	2513	c.2146C>T	c.(2146-2148)Ccc>Tcc	p.P716S	SUPT5H_ENST00000402194.2_Missense_Mutation_p.P712S|SUPT5H_ENST00000432763.2_Missense_Mutation_p.P716S|SUPT5H_ENST00000598725.1_Missense_Mutation_p.P716S|SUPT5H_ENST00000359191.6_Missense_Mutation_p.P712S			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	716	KOW 5.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CTCCCAGGGGCCCTACAAAGG	0.682000													23	41					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7301617	7301617	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:7301617G>A	ENST00000537408.1	+	12	2471	c.1933G>A	c.(1933-1935)Gtg>Atg	p.V645M	CLSTN3_ENST00000266546.6_Missense_Mutation_p.V633M			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	633					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						GGAGGGCTACGTGGTCGTCCT	0.587000													19	34					0	0	1	0	0
ZNF704	619279	broad.mit.edu	37	8	81553673	81553673	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:81553673G>A	ENST00000327835.3	-	9	1398	c.1167C>T	c.(1165-1167)taC>taT	p.Y389Y		NM_001033723.2	NP_001028895.1	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	389						intracellular	zinc ion binding			lung(9)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			TCTCCATCCCGTACACCTTCC	0.572000													12	64					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133541791	133541791	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:133541791T>C	ENST00000409261.1	-	14	2966	c.2593A>G	c.(2593-2595)Att>Gtt	p.I865V	NCKAP5_ENST00000317721.6_Missense_Mutation_p.I865V|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000405974.3_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	865							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TGTTTTGGAATGTGTGGATCT	0.537000													42	71					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	155041	155041	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:155041C>T	ENST00000283426.6	+	6	1026	c.976C>T	c.(976-978)Cag>Tag	p.Q326*		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	326					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		TGACAGCTGCCAGCTGACCGC	0.577000													36	39					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873408	36873408	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:36873408A>G	ENST00000429976.2	-	21	7781	c.7534T>C	c.(7534-7536)Tcg>Ccg	p.S2512P	TRANK1_ENST00000301807.6_Missense_Mutation_p.S1962P|TRANK1_ENST00000428977.2_Missense_Mutation_p.S1962P			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2512					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GCCTCACCCGAGACCACATAG	0.527000													54	74					0	0	1	0	0
COL4A6	1288	broad.mit.edu	37	X	107420159	107420159	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:107420159G>A	ENST00000334504.7	-	28	2831	c.2598C>T	c.(2596-2598)ggC>ggT	p.G866G	COL4A6_ENST00000372216.4_Silent_p.G867G|COL4A6_ENST00000545689.1_Silent_p.G866G|COL4A6_ENST00000394872.2_Silent_p.G867G|COL4A6_ENST00000538570.1_Silent_p.G866G	NM_033641.2	NP_378667.1	Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	867	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						TTCCAGGAAGGCCTTTTAGCC	0.532000									Alport syndrome with Diffuse Leiomyomatosis				89	164					0	0	1	0	0
EPS15L1	58513	broad.mit.edu	37	19	16528892	16528892	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:16528892G>A	ENST00000602009.1	-	5	1407	c.512C>T	c.(511-513)aCg>aTg	p.T171M	EPS15L1_ENST00000535753.2_Missense_Mutation_p.T325M|EPS15L1_ENST00000594975.1_Missense_Mutation_p.T325M|EPS15L1_ENST00000248070.6_Missense_Mutation_p.T325M|EPS15L1_ENST00000455140.2_Missense_Mutation_p.T325M|EPS15L1_ENST00000597937.1_Missense_Mutation_p.T325M			Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	325	EF-hand.|EH 2.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						TAACTTCCCCGTTTGCCTCGT	0.537000											OREG0025334	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	43					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103465909	103465909	+	Missense_Mutation	SNP	C	C	T	rs147856179	by1000genomes	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:103465909C>T	ENST00000361246.2	-	5	877	c.589G>A	c.(589-591)Gtg>Atg	p.V197M		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	197	Protein kinase.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TACCTGTGCACGTAATGAAGC	0.463000													41	78					0	0	1	0	0
ARL14EP	120534	broad.mit.edu	37	11	30354531	30354531	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:30354531G>A	ENST00000282032.3	+	3	760	c.545G>A	c.(544-546)gGt>gAt	p.G182D		NM_152316.1	NP_689529.1			ADP-ribosylation factor-like 14 effector protein																		GCAACCGCTGGTTCAGACAGG	0.378000													26	33					0	0	1	0	0
FAM53B	9679	broad.mit.edu	37	10	126312029	126312029	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:126312029C>T	ENST00000337318.3	-	5	1262	c.1051G>A	c.(1051-1053)Gct>Act	p.A351T	FAM53B_ENST00000392754.3_Missense_Mutation_p.A351T|RP11-12J10.3_ENST00000494792.1_Intron	NM_014661.3	NP_055476.3	Q14153	FA53B_HUMAN	family with sequence similarity 53, member B	351										cervix(1)|lung(5)|ovary(2)|pancreas(1)	9		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		GGGGTCCCAGCGGGGGTCCTG	0.706000													5	17					0	0	1	0	0
ZNF687	57592	broad.mit.edu	37	1	151261869	151261869	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:151261869C>T	ENST00000368879.2	+	5	2585	c.2487C>T	c.(2485-2487)tgC>tgT	p.C829C		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	829					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCTACAAGTGCGCCATGTGCG	0.612000													64	86					0	0	1	0	0
CNPPD1	27013	broad.mit.edu	37	2	220037432	220037432	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:220037432G>C	ENST00000409789.1	-	9	1536	c.1109C>G	c.(1108-1110)aCc>aGc	p.T370S	CNPPD1_ENST00000360507.5_Missense_Mutation_p.T370S			Q9BV87	CNPD1_HUMAN	cyclin Pas1/PHO80 domain containing 1	370	Pro-rich.				regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)	12						CAGGCCATAGGTATGGTACCA	0.617000													31	24					0	0	1	0	0
FAM71E1	112703	broad.mit.edu	37	19	50979571	50979571	+	Silent	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:50979571G>T	ENST00000600100.1	-	1	439	c.75C>A	c.(73-75)ctC>ctA	p.L25L	FAM71E1_ENST00000595790.1_Silent_p.L25L			Q6IPT2	F71E1_HUMAN	family with sequence similarity 71, member E1	25										breast(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		CGTCACACAAGAGCGGGCTCC	0.662000													17	28					3.52763e-06	3.63969e-06	1	1	0
ATP6V0A2	23545	broad.mit.edu	37	12	124228411	124228411	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:124228411A>G	ENST00000330342.3	+	10	1366	c.1118A>G	c.(1117-1119)aAc>aGc	p.N373S		NM_012463.3	NP_036595.2	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a2	373					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		ATCCGCACCAACAAATTCACC	0.453000													14	160					0	0	1	0	0
SMU1	55234	broad.mit.edu	37	9	33053232	33053232	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:33053232G>A	ENST00000397149.3	-	10	1229	c.1179C>T	c.(1177-1179)acC>acT	p.T393T	SMU1_ENST00000536631.1_Silent_p.T232T	NM_018225.2	NP_060695.2	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	393						cytoplasm|nucleus				endometrium(2)|lung(4)|ovary(2)|prostate(1)	9			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		CTGTCCCTGCGGTGCTGCCCA	0.398000													38	47					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6031488	6031488	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:6031488G>A	ENST00000409021.3	-	20	2849	c.2400C>T	c.(2398-2400)gaC>gaT	p.D800D	JAKMIP1_ENST00000409371.3_Silent_p.D615D	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	571					protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ACTCCAGTTTGTCCTCCAGTT	0.418000													5	9					0	0	1	0	0
ALOX15	246	broad.mit.edu	37	17	4534907	4534907	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:4534907A>G	ENST00000570836.1	-	15	2073	c.1977T>C	c.(1975-1977)agT>agC	p.S659S	ALOX15_ENST00000545513.1_Silent_p.S681S|ALOX15_ENST00000293761.3_Silent_p.S659S|ALOX15_ENST00000574640.1_Silent_p.S620S			P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	659	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(5)	20				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	AGATGGCCACACTGTTTTCCA	0.577000													40	59					0	0	1	0	0
PRKD3	23683	broad.mit.edu	37	2	37506904	37506904	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:37506904G>A	ENST00000379066.1	-	8	1919	c.1157C>T	c.(1156-1158)gCc>gTc	p.A386V	PRKD3_ENST00000234179.2_Missense_Mutation_p.A386V			O94806	KPCD3_HUMAN	protein kinase D3	386					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				TGTTTTAACGGCTTCTTCATC	0.408000													21	58					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142148219	142148219	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:142148219T>C	ENST00000519811.1	+	3	554	c.484T>C	c.(484-486)Tac>Cac	p.Y162H	DENND3_ENST00000518347.1_Missense_Mutation_p.Y162H|DENND3_ENST00000262585.2_Missense_Mutation_p.Y82H|DENND3_ENST00000424248.1_Missense_Mutation_p.Y82H			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	82	DENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTGGCCCAGTACTACCGGCC	0.512000													4	30					0	0	1	0	0
PCDP1	0	broad.mit.edu	37	2	120388230	120388230	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:120388230C>T	ENST00000602047.1	+	19	2070	c.958C>T	c.(958-960)Cga>Tga	p.R320*	PCDP1_ENST00000413369.3_Nonsense_Mutation_p.R606*			Q4G0U5	PCDP1_HUMAN		606						cilium	calmodulin binding					Colorectal(110;0.196)					AAAGCTTGCCCGAGCCCTAAA	0.448000													27	31					0	0	1	0	0
FBXO16	157574	broad.mit.edu	37	8	28314409	28314409	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:28314409C>T	ENST00000380254.2	-	5	529	c.381G>A	c.(379-381)caG>caA	p.Q127Q	FBXO16_ENST00000346498.2_Silent_p.Q115Q|FBXO16_ENST00000518734.1_Silent_p.Q115Q|FBXO16_ENST00000517436.1_5'UTR	NM_001258211.1|NM_172366.3	NP_001245140.1|NP_758954.1	Q8IX29	FBX16_HUMAN	F-box protein 16	127	F-box.									large_intestine(2)|ovary(1)	3		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		GCATCCAGAGCTGGTCCAGCT	0.423000													89	27					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139189663	139189663	+	Splice_Site	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:139189663C>T	ENST00000395297.1	-	11	1200	c.1029_splice	c.e11-1	p.V344_splice		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	344										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AACCTTCGGACCTGCAGAATA	0.373000										HNSCC(54;0.14)			13	26					0	0	1	0	0
ZNF280D	54816	broad.mit.edu	37	15	56970921	56970921	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:56970921G>T	ENST00000559237.1	-	10	1747	c.1064C>A	c.(1063-1065)cCc>cAc	p.P355H	ZNF280D_ENST00000396245.1_Missense_Mutation_p.P72H|ZNF280D_ENST00000559000.1_Missense_Mutation_p.P355H|ZNF280D_ENST00000267807.7_Missense_Mutation_p.P368H	NM_001002843.1	NP_001002843.1	Q6N043	Z280D_HUMAN	zinc finger protein 280D	368					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(4)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	30				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		AAATGGTGTGGGAAACTGACG	0.408000													33	48					6.84511e-11	7.26775e-11	1	1	0
CD300A	11314	broad.mit.edu	37	17	72470735	72470735	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:72470735T>C	ENST00000360141.3	+	3	732	c.444T>C	c.(442-444)ttT>ttC	p.F148F	CD300A_ENST00000392625.3_Silent_p.F35F|CD300A_ENST00000310828.5_Silent_p.F35F|CD300A_ENST00000361933.3_Intron|CD300A_ENST00000577511.1_Silent_p.F18F	NM_001256841.1|NM_007261.3	NP_001243770.1|NP_009192.2	Q9UGN4	CLM8_HUMAN	CD300a molecule	148					cell adhesion	integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(4)|urinary_tract(1)	16						CAACTGCATTTCCACCTGTAT	0.532000													49	69					0	0	1	0	0
DPY19L2P2	0	broad.mit.edu	37	7	102883486	102883486	+	RNA	SNP	C	C	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:102883486C>G	ENST00000312132.4	-	0	2623																											CCTCCCAGTTCAGTACCACTG	0.313000													3	15					0	0	1	0	0
IGF2R	3482	broad.mit.edu	37	6	160526039	160526039	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:160526039G>A	ENST00000356956.1	+	48	7547	c.7399G>A	c.(7399-7401)Gca>Aca	p.A2467T	IGF2R_ENST00000475584.1_Intron	NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	2467					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GTCCAGCTCTGCACAGCAGAA	0.597000													17	40					0	0	1	0	0
TGFBI	7045	broad.mit.edu	37	5	135392371	135392371	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:135392371T>C	ENST00000442011.2	+	12	1726	c.1565T>C	c.(1564-1566)aTc>aCc	p.I522T	TGFBI_ENST00000305126.8_Missense_Mutation_p.I522T	NM_000358.2	NP_000349.1	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	522	FAS1 4.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTAGCTGCCATCCAGTCTGCA	0.502000													28	63					0	0	1	0	0
AFP	174	broad.mit.edu	37	4	74315095	74315095	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:74315095T>C	ENST00000395792.2	+	9	1202	c.1102T>C	c.(1102-1104)Tca>Cca	p.S368P	AFP_ENST00000226359.2_Missense_Mutation_p.S368P	NM_001134.1	NP_001125.1	P02771	FETA_HUMAN	alpha-fetoprotein	368	Albumin 2.				transport		metal ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|urinary_tract(1)	22	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GCTTGCTGTCTCAGTAATTCT	0.373000									Alpha-Fetoprotein, Hereditary Persistence of				28	41					0	0	1	0	0
SLC16A2	6567	broad.mit.edu	37	X	73740968	73740968	+	Splice_Site	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:73740968A>G	ENST00000276033.5	+	2	962	c.797_splice	c.e2+1	p.S266_splice	SLC16A2_ENST00000587091.1_Splice_Site_p.S192_splice			P36021	MOT8_HUMAN	solute carrier family 16, member 2 (thyroid hormone transporter)	192						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	21					Pyruvic acid(DB00119)	CTCCTTCACCAGGTAAGGCTA	0.517000													50	56					0	0	1	0	0
TMEM102	284114	broad.mit.edu	37	17	7339922	7339922	+	Missense_Mutation	SNP	A	A	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:7339922A>C	ENST00000323206.1	+	3	897	c.624A>C	c.(622-624)aaA>aaC	p.K208N	TMEM102_ENST00000396568.1_Missense_Mutation_p.K208N|RP11-104H15.9_ENST00000570444.1_RNA|RP11-104H15.7_ENST00000575310.1_RNA	NM_178518.2	NP_848613.1	Q8N9M5	TM102_HUMAN	transmembrane protein 102	208					regulation of apoptosis|response to cytokine stimulus|signal transduction	cell surface|integral to membrane|intracellular	protein binding			kidney(1)|lung(3)|skin(1)	5		Prostate(122;0.173)				CTTTGGAAAAATCGCCTAGTG	0.552000													59	78					0	0	1	0	0
HAUS3	79441	broad.mit.edu	37	4	2242253	2242253	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:2242253C>T	ENST00000243706.4	-	2	650	c.421G>A	c.(421-423)Gaa>Aaa	p.E141K	HAUS3_ENST00000506763.1_Missense_Mutation_p.E141K|POLN_ENST00000511885.2_Intron|HAUS3_ENST00000443786.2_Missense_Mutation_p.E141K|POLN_ENST00000515357.1_Intron	NM_024511.5	NP_078787.2	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	141					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				breast(3)|endometrium(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GCTTCTTCTTCTTTAGCATTT	0.353000													26	40					0	0	1	0	0
RGS7	6000	broad.mit.edu	37	1	241033369	241033369	+	Missense_Mutation	SNP	C	C	T	rs149172715	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:241033369C>T	ENST00000366565.1	-	7	817	c.436G>A	c.(436-438)Gca>Aca	p.A146T	RGS7_ENST00000401882.1_Missense_Mutation_p.A93T|RGS7_ENST00000366563.1_Missense_Mutation_p.A146T|RGS7_ENST00000446183.2_Missense_Mutation_p.A62T|RGS7_ENST00000366562.4_Missense_Mutation_p.A146T|RGS7_ENST00000366564.1_Missense_Mutation_p.A146T|RGS7_ENST00000348120.2_Missense_Mutation_p.A93T|RGS7_ENST00000331110.7_Missense_Mutation_p.A120T|RGS7_ENST00000407727.1_Missense_Mutation_p.A146T	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	146					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TCATAGTCTGCGAGCTCCAGT	0.458000													30	44					0	0	1	0	0
CNOT10	25904	broad.mit.edu	37	3	32778914	32778914	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:32778914T>C	ENST00000328834.5	+	13	1843	c.1527T>C	c.(1525-1527)caT>caC	p.H509H	CNOT10_ENST00000331889.6_Intron|CNOT10-AS1_ENST00000475395.2_RNA|CNOT10_ENST00000538368.1_Silent_p.H281H|CNOT10_ENST00000454516.2_Silent_p.H569H	NM_015442.2	NP_056257.1	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	509				H -> Y (in Ref. 1; BAB14108).	nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(3)	23						GTAAAAGCCATGATGGAGATA	0.323000													10	25					0	0	1	0	0
RIC8A	60626	broad.mit.edu	37	11	214328	214328	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:214328A>G	ENST00000526104.1	+	10	2918	c.1574A>G	c.(1573-1575)gAc>gGc	p.D525G	RIC8A_ENST00000531541.1_3'UTR|RIC8A_ENST00000527696.1_Missense_Mutation_p.D519G|RIC8A_ENST00000325207.5_Missense_Mutation_p.D531G			Q9NPQ8	RIC8A_HUMAN	RIC8 guanine nucleotide exchange factor A	525						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)	13		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CTCTCctcggaccctgactcg	0.597000													4	10					0	0	1	0	0
CANX	821	broad.mit.edu	37	5	179146716	179146716	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:179146716C>A	ENST00000247461.4	+	9	1159	c.959C>A	c.(958-960)cCc>cAc	p.P320H	CANX_ENST00000504734.1_Missense_Mutation_p.P320H|CANX_ENST00000452673.2_Missense_Mutation_p.P320H|CANX_ENST00000415618.2_Missense_Mutation_p.P355H|CANX_ENST00000512607.2_Missense_Mutation_p.P212H	NM_001746.3	NP_001737.1	P27824	CALX_HUMAN	calnexin	320	4 X approximate repeats.|P domain (Extended arm) (By similarity).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|prostate(2)|urinary_tract(3)	22	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCCACAAAACCCGAAGGCTGG	0.423000													18	17					1.00905e-13	1.08051e-13	1	1	0
L3MBTL2	83746	broad.mit.edu	37	22	41612173	41612173	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:41612173C>A	ENST00000216237.5	+	4	585	c.427C>A	c.(427-429)Ctg>Atg	p.L143M	RP4-756G23.5_ENST00000451176.1_RNA|L3MBTL2_ENST00000489136.1_3'UTR|RP4-756G23.5_ENST00000441316.1_RNA	NM_031488.4	NP_113676.2	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2 (Drosophila)	143					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGCCAAAGTCCTGCACAAGGC	0.557000													13	25					5.50884e-06	5.67048e-06	1	1	0
BEGAIN	57596	broad.mit.edu	37	14	101004877	101004877	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:101004877G>A	ENST00000556751.1	-	5	4423	c.1019C>T	c.(1018-1020)cCg>cTg	p.P340L	BEGAIN_ENST00000443071.2_Missense_Mutation_p.P404L|BEGAIN_ENST00000355173.2_Missense_Mutation_p.P404L			Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	404						cytoplasm|membrane	protein binding			cervix(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)	14		Melanoma(154;0.212)				GGCGGTCCCCGGCTTGGCCCG	0.726000													9	8					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94486999	94486999	+	Missense_Mutation	SNP	C	C	T	rs146067291		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:94486999C>T	ENST00000375708.3	-	9	1975	c.1777G>A	c.(1777-1779)Gtg>Atg	p.V593M	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Missense_Mutation_p.V453M	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	593	Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						ACAAGGTGCACGAAGTCGGGG	0.632000													20	29					0	0	1	0	0
TMEM177	80775	broad.mit.edu	37	2	120438732	120438732	+	Silent	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:120438732G>T	ENST00000424086.1	+	2	776	c.303G>T	c.(301-303)ggG>ggT	p.G101G	TMEM177_ENST00000409951.1_Intron|TMEM177_ENST00000272521.6_Silent_p.G101G|TMEM177_ENST00000496203.1_Intron|TMEM177_ENST00000401466.1_Silent_p.G101G	NM_001105198.1	NP_001098668.1	Q53S58	TM177_HUMAN	transmembrane protein 177	101						integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	13	Colorectal(110;0.196)					TCCCTGCTGGGGCTGTGGTGG	0.562000													145	225					6.07058e-49	6.87843e-49	1	1	0
TSPAN31	0	broad.mit.edu	37	12	58139606	58139606	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:58139606G>A	ENST00000547992.1	+	2	274	c.142G>A	c.(142-144)Gga>Aga	p.G48R	TSPAN31_ENST00000553221.1_3'UTR|TSPAN31_ENST00000257910.3_Missense_Mutation_p.G48R|TSPAN31_ENST00000547472.1_Intron			Q12999	TSN31_HUMAN	tetraspanin 31	48					positive regulation of cell proliferation	integral to plasma membrane|membrane fraction				endometrium(1)|kidney(1)|lung(5)	7	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CATCATCGGCGGAGTCATTGC	0.552000													33	95					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133910007	133910007	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:133910007C>T	ENST00000220616.4	+	12	3155	c.3115C>T	c.(3115-3117)Cct>Tct	p.P1039S	TG_ENST00000377869.1_Missense_Mutation_p.P1039S	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1039	Thyroglobulin type-1 8.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AAGTTGGGAGCCTGTGCAGTG	0.597000													36	111					0	0	1	0	0
SCYL2	55681	broad.mit.edu	37	12	100709497	100709497	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:100709497G>A	ENST00000360820.2	+	9	1694	c.1257G>A	c.(1255-1257)caG>caA	p.Q419Q		NM_017988.4	NP_060458.3	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 (S. cerevisiae)	419					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(4)|lung(15)|ovary(2)|skin(1)	41						TGTTTAAGCAGCAGGAGCCAA	0.338000													17	20					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83806836	83806836	+	Splice_Site	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:83806836T>C	ENST00000349129.2	+	3	398		c.e3+2		DOPEY1_ENST00000369739.3_Splice_Site|DOPEY1_ENST00000536812.1_Splice_Site|DOPEY1_ENST00000237163.5_Splice_Site	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1						protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CTTAATAAGGTATGTCTGTAT	0.308000													117	81					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53586500	53586500	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:53586500A>G	ENST00000025008.5	-	7	1430	c.907T>C	c.(907-909)Ttt>Ctt	p.F303L	RB1CC1_ENST00000435644.2_Missense_Mutation_p.F303L|RB1CC1_ENST00000539297.1_Missense_Mutation_p.F303L|RB1CC1_ENST00000521611.1_Intron	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	303					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				ACATTAAAAAAGGGCAGATCA	0.388000													121	49					0	0	1	0	0
RP11-252A24.2	0	broad.mit.edu	37	16	74372644	74372644	+	RNA	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:74372644A>G	ENST00000429810.2	-	0	1552																											TACCCTTGTCAGGGGGAACAA	0.443000													10	48					0	0	1	0	0
ZNF329	79673	broad.mit.edu	37	19	58640477	58640477	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:58640477A>G	ENST00000598312.1	-	4	627	c.394T>C	c.(394-396)Tcc>Ccc	p.S132P	ZNF329_ENST00000358067.4_Missense_Mutation_p.S132P	NM_024620.3	NP_078896.3	Q86UD4	ZN329_HUMAN	zinc finger protein 329	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(10)|lung(5)|skin(3)|urinary_tract(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		ACTTCCATGGAATGGTTGAAG	0.423000													62	55					0	0	1	0	0
PQLC1	80148	broad.mit.edu	37	18	77703350	77703350	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:77703350C>T	ENST00000397778.2	-	3	498	c.316G>A	c.(316-318)Gcc>Acc	p.A106T	PQLC1_ENST00000590381.1_Missense_Mutation_p.A106T|PQLC1_ENST00000409073.1_Missense_Mutation_p.A23T|PQLC1_ENST00000357575.4_Missense_Mutation_p.A106T	NM_025078.4	NP_079354.2	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1	106						integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	9		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		CGGCGCCTGGCGTTGAGCTCG	0.582000													116	142					0	0	1	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65351790	65351790	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:65351790C>T	ENST00000309295.4	+	10	3437	c.3172C>T	c.(3172-3174)Cgc>Tgc	p.R1058C		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	1058	CH.									central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						CCGTGGCGTCCGCATCACCAA	0.627000													70	95					0	0	1	0	0
ATG13	9776	broad.mit.edu	37	11	46667538	46667538	+	Splice_Site	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:46667538A>G	ENST00000434074.1	+	4	958	c.270_splice	c.e4+1	p.E90_splice	ATG13_ENST00000526508.1_Splice_Site_p.E90_splice|ATG13_ENST00000530500.1_Splice_Site_p.E11_splice|ATG13_ENST00000528494.1_Splice_Site_p.E90_splice|ATG13_ENST00000451945.1_Splice_Site_p.E90_splice|ATG13_ENST00000529655.1_Splice_Site_p.E90_splice|ATG13_ENST00000524625.1_Splice_Site_p.E90_splice|ATG13_ENST00000312040.4_Splice_Site_p.E90_splice|ATG13_ENST00000359513.4_Splice_Site_p.E90_splice	NM_001205120.1	NP_001192049.1	O75143	ATG13_HUMAN	autophagy related 13	90					autophagic vacuole assembly	cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	15						AAGACTTCTGAGGTAAGGCTA	0.502000													25	31					0	0	1	0	0
ASPHD1	253982	broad.mit.edu	37	16	29912571	29912571	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:29912571G>A	ENST00000308748.5	+	1	531	c.279G>A	c.(277-279)tgG>tgA	p.W93*	ASPHD1_ENST00000483405.1_Intron	NM_181718.3	NP_859069.2	Q5U4P2	ASPH1_HUMAN	aspartate beta-hydroxylase domain containing 1	93					peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			endometrium(4)|large_intestine(2)|lung(1)|prostate(1)	8						TGTTCCTCTGGTACTGCTACC	0.682000													55	83					0	0	1	0	0
ARHGAP4	393	broad.mit.edu	37	X	153179298	153179298	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:153179298G>A	ENST00000370028.3	-	9	1245	c.1188C>T	c.(1186-1188)gaC>gaT	p.D396D	ARHGAP4_ENST00000537206.1_Silent_p.D333D|ARHGAP4_ENST00000350060.5_Silent_p.D356D|ARHGAP4_ENST00000370016.1_Silent_p.D335D|ARHGAP4_ENST00000393721.1_Silent_p.D178D	NM_001164741.1	NP_001158213.1	P98171	RHG04_HUMAN	Rho GTPase activating protein 4	356					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCAGAATCTCGTCCCGCAGCT	0.652000													23	37					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042527	75042527	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:75042527G>A	ENST00000343932.4	+	2	511	c.448G>A	c.(448-450)Gcc>Acc	p.A150T		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	150					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding	p.A150T(1)		breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CTTCTCCATCGCCTCTGACCC	0.622000													108	167					0	0	1	0	0
COX6A1	1337	broad.mit.edu	37	12	120878307	120878307	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:120878307G>A	ENST00000229379.2	+	3	334	c.297G>A	c.(295-297)gtG>gtA	p.V99V	AL021546.6_ENST00000551806.1_Intron	NM_004373.3	NP_004364.2	P12074	CX6A1_HUMAN	cytochrome c oxidase subunit VIa polypeptide 1	99					respiratory electron transport chain	mitochondrial respiratory chain complex IV	cytochrome-c oxidase activity					all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACCCTCATGTGAATCCACTTC	0.458000													19	23					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80049428	80049428	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:80049428C>T	ENST00000306749.2	-	9	1380	c.1162G>A	c.(1162-1164)Gtg>Atg	p.V388M		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	388	Beta-ketoacyl synthase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	TTGATGCCCACGTTGCCGCCA	0.682000													10	9					0	0	1	0	0
ZHX1	11244	broad.mit.edu	37	8	124266662	124266662	+	Nonsense_Mutation	SNP	T	T	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:124266662T>A	ENST00000395571.3	-	3	2142	c.1525A>T	c.(1525-1527)Aaa>Taa	p.K509*	ZHX1_ENST00000297857.2_Nonsense_Mutation_p.K509*|ZHX1-C8ORF76_ENST00000357082.4_Intron|ZHX1_ENST00000522655.1_Nonsense_Mutation_p.K509*	NM_001017926.2|NM_007222.4	NP_001017926.1|NP_009153.3	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	509	Required for interaction with NFYA.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			AACCATTTTTTAATCTCTCCT	0.348000													80	215					0	0	1	0	0
PCDHB6	0	broad.mit.edu	37	5	140531421	140531421	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140531421G>A	ENST00000231136.1	+	1	1583	c.1583G>A	c.(1582-1584)cGc>cAc	p.R528H	PCDHB6_ENST00000543635.1_Missense_Mutation_p.R392H	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		528	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCGAGTTCCGCGTGGGCGCC	0.657000													113	116					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25715915	25715915	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:25715915C>T	ENST00000520164.1	-	14	1985	c.1448G>A	c.(1447-1449)aGc>aAc	p.S483N	EBF2_ENST00000408929.3_Missense_Mutation_p.S335N|EBF2_ENST00000535548.1_Missense_Mutation_p.S214N	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	483	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GGGGACATTGCTGTAGCCATT	0.517000													38	120					0	0	1	0	0
CDK16	5127	broad.mit.edu	37	X	47085770	47085770	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:47085770C>T	ENST00000457458.2	+	9	1323	c.903C>T	c.(901-903)aaC>aaT	p.N301N	CDK16_ENST00000357227.4_Silent_p.N295N|CDK16_ENST00000518022.1_Silent_p.N295N|CDK16_ENST00000276052.6_Silent_p.N369N	NM_033018.3	NP_148978.2	Q00536	CDK16_HUMAN	cyclin-dependent kinase 16	295	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(3)	11						TGCTCATCAACGAGAGGGGAG	0.587000													17	20					0	0	1	0	0
HLA-DPA1	3113	broad.mit.edu	37	6	33037547	33037547	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:33037547C>T	ENST00000419277.1	-	3	346	c.217G>A	c.(217-219)Gtc>Atc	p.V73I	HLA-DPA1_ENST00000428995.1_Missense_Mutation_p.V73I|HLA-DPA1_ENST00000463066.1_5'UTR	NM_001242524.1|NM_001242525.1	NP_001229453.1|NP_001229454.1	P20036	DPA1_HUMAN	major histocompatibility complex, class II, DP alpha 1	73	Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			kidney(5)|large_intestine(1)|lung(6)|prostate(1)|skin(2)	15						AGATGCCAGACGGTCTCCTTC	0.458000													41	28					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33581397	33581397	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:33581397C>T	ENST00000321505.4	+	6	3247	c.3067C>T	c.(3067-3069)Cag>Tag	p.Q1023*	KIAA1549L_ENST00000389726.3_Nonsense_Mutation_p.Q1029*|KIAA1549L_ENST00000265654.5_Nonsense_Mutation_p.Q1029*					KIAA1549-like																		CCTCCTCAGCCAGCTCTCGGC	0.597000													59	99					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72666576	72666576	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:72666576C>T	ENST00000261180.4	+	1	114	c.18C>T	c.(16-18)gcC>gcT	p.A6A	TRHDE-AS1_ENST00000426250.3_RNA	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	6					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						AAGACGACGCCGCGCTTCGGG	0.662000													11	10					0	0	1	0	0
AEBP1	165	broad.mit.edu	37	7	44146234	44146234	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:44146234A>G	ENST00000223357.3	+	2	648	c.343A>G	c.(343-345)Agg>Ggg	p.R115G		NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	115	Pro-rich.				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						GGGGTCCCCCAGGCCGCCCAA	0.577000													15	5					0	0	1	0	0
PHLDA2	7262	broad.mit.edu	37	11	2950201	2950201	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:2950201C>T	ENST00000314222.4	-	1	484	c.394G>A	c.(394-396)Gcc>Acc	p.A132T		NM_003311.3	NP_003302.1	Q53GA4	PHLA2_HUMAN	pleckstrin homology-like domain, family A, member 2	132	Poly-Ala.				apoptosis	cytoplasm|membrane				central_nervous_system(1)	1		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAGGGTGCGGCGGCCGCGGCA	0.756000													6	2					0	0	1	0	0
KRTAP10-4	386672	broad.mit.edu	37	21	45994016	45994016	+	Silent	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr21:45994016C>A	ENST00000400374.3	+	1	411	c.381C>A	c.(379-381)ccC>ccA	p.P127P	TSPEAR_ENST00000323084.4_Intron	NM_198687.1	NP_941960.1	P60372	KR104_HUMAN	keratin associated protein 10-4	127	36 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(1)	18						GCTGTGTGCCCGTCTGCTGTG	0.647000													20	210					2.94398e-08	3.08099e-08	1	1	0
PLCH1	23007	broad.mit.edu	37	3	155206447	155206447	+	Splice_Site	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:155206447A>G	ENST00000460012.1	-	20	2807		c.e20+1		PLCH1_ENST00000334686.6_Splice_Site|PLCH1_ENST00000414191.1_Splice_Site|PLCH1_ENST00000447496.2_Splice_Site|PLCH1_ENST00000340059.7_Splice_Site|PLCH1_ENST00000494598.1_Splice_Site			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1						lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GCTCATACCTACCAGGCACTA	0.408000													24	28					0	0	1	0	0
KCNA3	3738	broad.mit.edu	37	1	111217016	111217016	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:111217016T>C	ENST00000369769.2	-	1	639	c.416A>G	c.(415-417)tAc>tGc	p.Y139C		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	139						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGGGTCGAAGTACCTCATGCG	0.647000													73	84					0	0	1	0	0
ALDH3B1	221	broad.mit.edu	37	11	67790205	67790205	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:67790205G>A	ENST00000539229.1	+	10	1202	c.1086G>A	c.(1084-1086)ctG>ctA	p.L362L	ALDH3B1_ENST00000316367.6_Intron|ALDH3B1_ENST00000342456.6_Silent_p.L326L|ALDH3B1_ENST00000434449.1_3'UTR|ALDH3B1_ENST00000007633.8_Silent_p.L362L	NM_001161473.1	NP_001154945.1	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3 family, member B1	364					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase									NADH(DB00157)	CCCTGGCCCTGTACGCCTTCT	0.677000													57	56					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179438269	179438269	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:179438269A>G	ENST00000589042.1	-	326	72814	c.72590T>C	c.(72589-72591)gTc>gCc	p.V24197A	TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V15257A|TTN_ENST00000342992.6_Missense_Mutation_p.V21629A|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V15324A|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V15132A|TTN_ENST00000591111.1_Missense_Mutation_p.V22556A|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22556	Ig-like 121.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACAGCCATGACACGGAATAT	0.453000													81	158					0	0	1	0	0
ZNF260	339324	broad.mit.edu	37	19	37005246	37005246	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:37005246T>C	ENST00000523638.1	-	3	2016	c.895A>G	c.(895-897)Aca>Gca	p.T299A	ZNF260_ENST00000588993.1_Missense_Mutation_p.T299A|ZNF260_ENST00000592282.1_Missense_Mutation_p.T299A|ZNF260_ENST00000593142.1_Missense_Mutation_p.T299A	NM_001166036.1|NM_001166037.1|NM_001166038.1	NP_001159508.1|NP_001159509.1|NP_001159510.1	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	299					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)	15	Esophageal squamous(110;0.162)					TTCTCTCCTGTATGAATATTG	0.353000													53	50					0	0	1	0	0
SCARB2	950	broad.mit.edu	37	4	77091020	77091020	+	Splice_Site	SNP	A	A	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:77091020A>C	ENST00000264896.2	-	8	1462	c.1113_splice	c.e8+1	p.P371_splice	SCARB2_ENST00000452464.2_Splice_Site_p.P228_splice	NM_005506.3	NP_005497.1	Q14108	SCRB2_HUMAN	scavenger receptor class B, member 2	371					cell adhesion|protein targeting to lysosome	integral to plasma membrane|lysosomal lumen|lysosomal membrane|membrane fraction	enzyme binding|receptor activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(3)|prostate(2)|skin(1)	22			Lung(101;0.196)			ATGTACTCACAGGATTAATGT	0.393000													38	61					0	0	1	0	0
FBXO45	200933	broad.mit.edu	37	3	196304421	196304421	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:196304421A>G	ENST00000311630.6	+	2	713	c.416A>G	c.(415-417)cAg>cGg	p.Q139R	FBXO45_ENST00000440469.1_5'UTR	NM_001105573.1	NP_001099043.1	P0C2W1	FBSP1_HUMAN	F-box protein 45	139	B30.2/SPRY.				nervous system development|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	cell junction|postsynaptic membrane|presynaptic membrane	protein binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	7	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;2.75e-23)|all cancers(36;2.47e-21)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00314)		CCCATTGCTCAGAGCACTGAT	0.498000													13	20					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183515755	183515755	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:183515755G>A	ENST00000305135.5	+	22	3337	c.3142G>A	c.(3142-3144)Gtc>Atc	p.V1048I		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1048					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GCAGCAGGCCGTCCTGACGAT	0.512000													29	35					0	0	1	0	0
NET1	10276	broad.mit.edu	37	10	5494824	5494824	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:5494824A>G	ENST00000355029.4	+	6	677	c.535A>G	c.(535-537)Ata>Gta	p.I179V	NET1_ENST00000380359.3_Missense_Mutation_p.I125V|NET1_ENST00000542715.1_5'UTR	NM_001047160.1	NP_001040625.1	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming 1	179	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(4)|kidney(2)|large_intestine(9)|lung(5)|prostate(2)|skin(1)	23						TTTTTAGGCAATATATGAAAT	0.323000													9	73					0	0	1	0	0
CCDC157	550631	broad.mit.edu	37	22	30771603	30771603	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:30771603A>G	ENST00000405659.1	+	10	2517	c.1808A>G	c.(1807-1809)cAa>cGa	p.Q603R	CCDC157_ENST00000338306.3_Missense_Mutation_p.Q603R|RP1-130H16.16_ENST00000332468.4_RNA			Q569K6	CC157_HUMAN	coiled-coil domain containing 157	603										central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(1)	15						GGGCGGCTCCAATCAATGCTG	0.617000													26	34					0	0	1	0	0
ZNF22	7570	broad.mit.edu	37	10	45499133	45499133	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:45499133C>T	ENST00000298299.3	+	2	910	c.317C>T	c.(316-318)aCg>aTg	p.T106M	CEP164P1_ENST00000456938.2_RNA	NM_006963.4	NP_008894.2	P17026	ZNF22_HUMAN	zinc finger protein 22	106					odontogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|plasma membrane	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|lung(2)	8		Prostate(175;0.0352)|all_neural(218;0.202)				CGGATCCATACGGGGGAAAAG	0.418000													24	60					0	0	1	0	0
FBL	2091	broad.mit.edu	37	19	40331278	40331278	+	Missense_Mutation	SNP	C	C	T	rs139541583		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:40331278C>T	ENST00000221801.3	-	2	273	c.160G>A	c.(160-162)Ggt>Agt	p.G54S		NM_001436.3	NP_001427.2	P22087	FBRL_HUMAN	fibrillarin	54	DMA/Gly-rich.				rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)	9	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		cctcctccaccgccgccgccg	0.662000													17	17					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8521547	8521547	+	Splice_Site	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:8521547C>T	ENST00000381196.4	-	17	1235		c.e17-1		PTPRD_ENST00000486161.1_Splice_Site|PTPRD_ENST00000356435.5_Splice_Site|PTPRD_ENST00000355233.5_Splice_Site|PTPRD_ENST00000397606.3_Splice_Site|PTPRD_ENST00000397611.3_Splice_Site|PTPRD_ENST00000397617.3_Splice_Site|PTPRD_ENST00000540109.1_Splice_Site|PTPRD_ENST00000360074.4_Splice_Site|PTPRD_ENST00000537002.1_Splice_Site|PTPRD_ENST00000358503.5_Splice_Site	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D						transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ACACGGCGAACTGGAACAAAA	0.438000										TSP Lung(15;0.13)			34	45					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176696631	176696631	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:176696631C>T	ENST00000439151.2	+	16	5377	c.5332C>T	c.(5332-5334)Cga>Tga	p.R1778*	NSD1_ENST00000347982.4_Nonsense_Mutation_p.R1509*|NSD1_ENST00000354179.4_Nonsense_Mutation_p.R1509*|NSD1_ENST00000361032.4_Nonsense_Mutation_p.R1675*	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1778	PWWP 2.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding	p.R1778*(2)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CTGCCATCCTCGAGCTGTTCC	0.468000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			50	34					0	0	1	0	0
CLCN4	0	broad.mit.edu	37	X	10153098	10153098	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:10153098G>A	ENST00000380833.4	+	3	417	c.26G>A	c.(25-27)gGc>gAc	p.G9D	CLCN4_ENST00000380829.1_Missense_Mutation_p.G9D|CLCN4_ENST00000421085.2_Intron	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	9						early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GCGATGAGTGGCTCTGGAAAC	0.517000													5	107					0	0	1	0	0
KCNQ4	9132	broad.mit.edu	37	1	41284281	41284281	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:41284281C>T	ENST00000347132.5	+	4	719	c.637C>T	c.(637-639)Cgc>Tgc	p.R213C	KCNQ4_ENST00000509682.2_Missense_Mutation_p.R213C	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4	213					sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			GCAGATCCTGCGCATGGTGCG	0.687000													23	25					0	0	1	0	0
RXFP2	122042	broad.mit.edu	37	13	32351561	32351561	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:32351561G>A	ENST00000298386.2	+	8	761	c.690G>A	c.(688-690)acG>acA	p.T230T	RXFP2_ENST00000380314.1_Silent_p.T230T	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	230						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		GCTTGTTTACGGGATTAAATT	0.318000													6	13					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32768513	32768513	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:32768513G>A	ENST00000421745.2	+	62	12631	c.12497G>A	c.(12496-12498)cGt>cAt	p.R4166H		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4166					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TTATTTCTTCGTCTTCCGGGC	0.483000													92	132					0	0	1	0	0
KLC4	89953	broad.mit.edu	37	6	43034148	43034148	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:43034148C>T	ENST00000394056.2	+	6	1171	c.676C>T	c.(676-678)Cgc>Tgc	p.R226C	KLC4_ENST00000394058.1_Missense_Mutation_p.R226C|KLC4_ENST00000259708.3_Missense_Mutation_p.R244C|KLC4_ENST00000347162.5_Missense_Mutation_p.R226C|KLC4_ENST00000453940.2_Missense_Mutation_p.R149C|KLC4_ENST00000458460.2_Missense_Mutation_p.R226C|KLC4_ENST00000479388.1_Missense_Mutation_p.R226C			Q9NSK0	KLC4_HUMAN	kinesin light chain 4	226						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			AGCCCAAGGTCGCTATGAGGT	0.597000													43	84					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111117897	111117897	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:111117897C>A	ENST00000360467.5	+	25	2228	c.1922C>A	c.(1921-1923)cCt>cAt	p.P641H		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	641	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GCCGGCTTACCTGGACCACCA	0.597000													35	32					1.06647e-15	1.15184e-15	1	1	0
PCDHGB7	0	broad.mit.edu	37	5	140799074	140799074	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140799074G>A	ENST00000398594.2	+	1	1648	c.1648G>A	c.(1648-1650)Gtg>Atg	p.V550M	PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA10_ENST00000398610.2_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCCTGCGCGTGTTGGTGGG	0.721000													23	71					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25675930	25675930	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:25675930C>A	ENST00000382051.3	+	11	1279	c.1229C>A	c.(1228-1230)cCc>cAc	p.P410H	SLC34A2_ENST00000504570.1_Missense_Mutation_p.P409H|SLC34A2_ENST00000503434.1_Missense_Mutation_p.P409H	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	410					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				TTCCCCTTTCCCTTTGCATGG	0.602000			T	ROS1	NSCLC								22	45					7.41877e-09	7.82003e-09	1	1	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642000													7	169					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234070428	234070428	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:234070428C>T	ENST00000359570.5	+	13	1160	c.1160C>T	c.(1159-1161)cCg>cTg	p.P387L	INPP5D_ENST00000455936.2_Missense_Mutation_p.P151L|INPP5D_ENST00000450745.1_Missense_Mutation_p.P151L|INPP5D_ENST00000538935.1_Missense_Mutation_p.P386L			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	399					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TCAGAGCAGCCGGAGCCCGAC	0.587000													13	10					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65402797	65402797	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:65402797C>T	ENST00000355703.3	+	31	5601	c.5062C>T	c.(5062-5064)Cgc>Tgc	p.R1688C		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1688						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CCCAGCATGGCGCAGCGCCAT	0.612000													12	7					0	0	1	0	0
SLC16A11	162515	broad.mit.edu	37	17	6946780	6946780	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:6946780G>A	ENST00000308009.1	-	1	462	c.125C>T	c.(124-126)gCg>gTg	p.A42V	SLC16A11_ENST00000447225.1_Missense_Mutation_p.A18V	NM_153357.1	NP_699188.1	Q8NCK7	MOT11_HUMAN	solute carrier family 16, member 11	42						integral to membrane|plasma membrane	symporter activity			endometrium(2)|kidney(2)|lung(2)|ovary(1)|skin(2)	9						GGCTGCGGCCGCCACCACCCA	0.697000													15	11					0	0	1	0	0
ABCG8	64241	broad.mit.edu	37	2	44105047	44105047	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:44105047T>C	ENST00000272286.2	+	13	2107	c.2017T>C	c.(2017-2019)Tgg>Cgg	p.W673R		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	673					cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AAGTCAAGACTGGTGATTCAC	0.562000											OREG0014582	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	32					0	0	1	0	0
DHX29	54505	broad.mit.edu	37	5	54570837	54570837	+	Splice_Site	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:54570837T>C	ENST00000251636.5	-	15	2577	c.2427_splice	c.e15-1	p.E810_splice	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	810							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TGGGATGTATTCCTAAAAGAA	0.358000													38	27					0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	79973119	79973119	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:79973119C>T	ENST00000373275.4	-	19	2400	c.2184G>A	c.(2182-2184)gcG>gcA	p.A728A	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	728										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						TTCTGCTCCACGCCATGAGAT	0.393000													56	88					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50152666	50152666	+	Silent	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:50152666G>T	ENST00000284509.6	-	28	3445	c.3304C>A	c.(3304-3306)Cgg>Agg	p.R1102R	ATP8B4_ENST00000559829.1_Silent_p.R1102R	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	1102					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TTCTGCCACCGGCGGATCTGG	0.502000													40	62					7.40236e-40	8.35505e-40	1	1	0
MAGEE1	57692	broad.mit.edu	37	X	75649801	75649801	+	Missense_Mutation	SNP	A	A	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:75649801A>C	ENST00000361470.2	+	1	1756	c.1478A>C	c.(1477-1479)cAg>cCg	p.Q493P		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	493	MAGE 1.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						CCTATGGAACAGAACGTAGCT	0.493000													38	43					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26436415	26436415	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:26436415C>T	ENST00000265944.5	+	23	2728	c.2562C>T	c.(2560-2562)gaC>gaT	p.D854D	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	854	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						TTCCTACTGACATTGTGCTAC	0.393000													34	75					0	0	1	0	0
DNAJB8	165721	broad.mit.edu	37	3	128181453	128181453	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:128181453G>A	ENST00000469083.1	-	2	3193	c.636C>T	c.(634-636)gaC>gaT	p.D212D	DNAJB8_ENST00000319153.3_Silent_p.D212D			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	212					protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		TGAGCTGCCCGTCTTCCTCCA	0.612000													90	100					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190606079	190606079	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:190606079G>C	ENST00000520309.1	+	20	3800	c.3712G>C	c.(3712-3714)Gca>Cca	p.A1238P	ANKAR_ENST00000313581.4_Missense_Mutation_p.A1238P|ANKAR_ENST00000281412.6_3'UTR|ANKAR_ENST00000438402.2_3'UTR|ANKAR_ENST00000431575.2_Missense_Mutation_p.A1167P	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1238						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			GAATTTAATAGCAAGCCTGGC	0.338000													25	42					0	0	1	0	0
IMPDH1	3614	broad.mit.edu	37	7	128037026	128037026	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:128037026G>A	ENST00000338791.6	-	11	1475	c.1125C>T	c.(1123-1125)atC>atT	p.I375I	IMPDH1_ENST00000378717.4_Silent_p.I306I|IMPDH1_ENST00000480861.1_Silent_p.I285I|IMPDH1_ENST00000470772.1_Silent_p.I289I|IMPDH1_ENST00000348127.6_Silent_p.I339I|IMPDH1_ENST00000419067.2_Silent_p.I342I|IMPDH1_ENST00000343214.4_Silent_p.I265I|IMPDH1_ENST00000496200.1_Silent_p.I265I|IMPDH1_ENST00000354269.5_Silent_p.I365I	NM_000883.3	NP_000874.2	P20839	IMDH1_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 1	290					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)	22					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	ACTTCTGTTTGATGTAATGCA	0.562000													35	57					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10555851	10555851	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:10555851G>A	ENST00000583535.1	-	4	321	c.234C>T	c.(232-234)taC>taT	p.Y78Y	MYH3_ENST00000226209.7_Silent_p.Y78Y	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	78	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity	p.Y78Y(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						GGTTCATGGCGTACACATCCT	0.468000													45	51					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16456084	16456084	+	Splice_Site	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:16456084G>A	ENST00000358432.5	-	16	2824	c.2669_splice	c.e16-1	p.R890_splice		NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	890	Mediates interaction with ARHGEF16 and ELMO2.|Negatively regulates interaction with ARHGEF16.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GGATAGACACGCtgcaacagg	0.652000													12	28					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67081776	67081776	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:67081776G>A	ENST00000284425.2	-	31	4193	c.4019C>T	c.(4018-4020)aCt>aTt	p.T1340I	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1340	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					CTCTCCAGCAGTTGGCTTTGT	0.358000													13	15					0	0	1	0	0
ASAP3	55616	broad.mit.edu	37	1	23767955	23767955	+	Silent	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:23767955G>T	ENST00000336689.3	-	9	803	c.759C>A	c.(757-759)gcC>gcA	p.A253A	ASAP3_ENST00000437606.2_Silent_p.A244A	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	253					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						CGTCCTCCTGGGCCTGATGGA	0.582000													9	20					0.0477658	0.0479846	1	1	0
EXD3	54932	broad.mit.edu	37	9	140243587	140243587	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:140243587G>A	ENST00000340951.4	-	16	2000	c.1805C>T	c.(1804-1806)gCg>gTg	p.A602V	EXD3_ENST00000342129.4_Missense_Mutation_p.A282V	NM_017820.3	NP_060290.3	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	602					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)	12						CGGTGCTGACGCTTTCTGCAG	0.667000													10	12					0	0	1	0	0
PHC3	80012	broad.mit.edu	37	3	169846643	169846643	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:169846643C>T	ENST00000494943.1	-	8	1649	c.1581G>A	c.(1579-1581)caG>caA	p.Q527Q	PHC3_ENST00000467570.1_Silent_p.Q486Q|PHC3_ENST00000495893.1_Silent_p.Q539Q			Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)	527	Gln-rich.|Pro-rich.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			GAATTTCAGGCTGCACTTGTA	0.507000													69	74					0	0	1	0	0
FGFRL1	53834	broad.mit.edu	37	4	1017702	1017702	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:1017702C>T	ENST00000398484.2	+	6	1111	c.531C>T	c.(529-531)caC>caT	p.H177H	FGFRL1_ENST00000264748.6_Silent_p.H177H|FGFRL1_ENST00000510644.1_Silent_p.H177H|FGFRL1_ENST00000504138.1_Silent_p.H177H			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	177	Ig-like C2-type 2.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CCAGCGGGCACCCTCGGCCCG	0.667000													6	8					0	0	1	0	0
PCDH12	51294	broad.mit.edu	37	5	141334689	141334689	+	Missense_Mutation	SNP	G	G	T	rs439293		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:141334689G>T	ENST00000231484.3	-	1	3938	c.2728C>A	c.(2728-2730)Ctg>Atg	p.L910M		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	910					neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCCGTCTCAGGGTTGCAGAG	0.632000													36	85					1.96642e-18	2.15299e-18	1	1	0
DPYSL2	1808	broad.mit.edu	37	8	26481666	26481666	+	Silent	SNP	C	C	T	rs113199330	by1000genomes	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:26481666C>T	ENST00000311151.5	+	4	733	c.321C>T	c.(319-321)caC>caT	p.H107H	DPYSL2_ENST00000523027.1_Silent_p.H71H|DPYSL2_ENST00000521913.1_Silent_p.H71H	NM_001386.5	NP_001377.1	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	107					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			breast(1)|endometrium(5)|large_intestine(8)|lung(3)|prostate(1)|skin(1)|stomach(1)	20		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		TAGTTGACCACGTTGTTCCTG	0.532000													16	104					0	0	1	0	0
HS6ST2	90161	broad.mit.edu	37	X	132092544	132092544	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:132092544G>A	ENST00000370836.2	-	2	502	c.87C>T	c.(85-87)cgC>cgT	p.R29R	HS6ST2_ENST00000521489.1_Silent_p.R29R	NM_147175.3	NP_671704.3	Q96MM7	H6ST2_HUMAN	heparan sulfate 6-O-sulfotransferase 2	29						integral to membrane	sulfotransferase activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(2)	9	Acute lymphoblastic leukemia(192;0.000127)					TGGAATGCCGGCGGGGACAGG	0.711000													12	13					0	0	1	0	0
SLC25A25	114789	broad.mit.edu	37	9	130860955	130860955	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:130860955G>A	ENST00000373064.5	+	1	373	c.110G>A	c.(109-111)aGt>aAt	p.S37N	SLC25A25_ENST00000373069.5_Intron|SLC25A25_ENST00000433501.1_5'UTR|SLC25A25_ENST00000432073.2_Intron|SLC25A25_ENST00000373068.2_Intron|SLC25A25_ENST00000373066.5_Intron	NM_052901.4	NP_443133.2	Q6KCM7	SCMC2_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	37					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)	10						TTCAAGCTCAGTGTCTTCATC	0.582000													66	94					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136595269	136595269	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:136595269G>A	ENST00000371872.4	-	5	988	c.731C>T	c.(730-732)aCg>aTg	p.T244M	SARDH_ENST00000439388.1_Missense_Mutation_p.T244M|SARDH_ENST00000298628.5_Missense_Mutation_p.T244M|SARDH_ENST00000371867.1_Missense_Mutation_p.T155M|SARDH_ENST00000422262.2_Missense_Mutation_p.T76M	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	244					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		AAAATCATCCGTCCACACACG	0.587000													33	55					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150840935	150840935	+	Missense_Mutation	SNP	A	A	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:150840935A>C	ENST00000370357.4	+	14	1963	c.1718A>C	c.(1717-1719)aAg>aCg	p.K573T		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	573						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					cagccactgaagcaTAATGTC	0.522000													31	39					0	0	1	0	0
L1CAM	3897	broad.mit.edu	37	X	153129471	153129471	+	Splice_Site	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:153129471G>A	ENST00000370060.1	-	26	3513	c.3322_splice	c.e26-1	p.G1108_splice	L1CAM_ENST00000543994.1_Splice_Site_p.G1110_splice|L1CAM_ENST00000538883.1_Splice_Site_p.G1110_splice|L1CAM_ENST00000361699.4_Splice_Site_p.G1108_splice|L1CAM_ENST00000370055.1_Splice_Site_p.G1103_splice|L1CAM_ENST00000370057.3_Splice_Site_p.G1108_splice|L1CAM_ENST00000361981.3_Splice_Site_p.G1103_splice	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	1108	Fibronectin type-III 5.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCTCACGCGGCCTGAGGGTG	0.637000													23	37					0	0	1	0	0
KRT76	51350	broad.mit.edu	37	12	53162616	53162616	+	Missense_Mutation	SNP	A	A	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:53162616A>T	ENST00000332411.2	-	9	1851	c.1798T>A	c.(1798-1800)Tcc>Acc	p.S600T		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	600	Tail.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CCAGAGCTGGAGCCCATTCCA	0.622000													25	47					0	0	1	0	0
OR6V1	346517	broad.mit.edu	37	7	142749858	142749858	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:142749858C>T	ENST00000418316.1	+	1	442	c.421C>T	c.(421-423)Cag>Tag	p.Q141*		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					TATGTGTGTCCAGCTGGCTGG	0.587000													6	90					0	0	1	0	0
WFS1	7466	broad.mit.edu	37	4	6302765	6302765	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:6302765G>A	ENST00000226760.1	+	8	1413	c.1243G>A	c.(1243-1245)Gtc>Atc	p.V415I	WFS1_ENST00000503569.1_Missense_Mutation_p.V415I	NM_001145853.1|NM_006005.3	NP_001139325.1|NP_005996.2	O76024	WFS1_HUMAN	Wolfram syndrome 1 (wolframin)	415			Missing (in WFS).		endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	21				Colorectal(103;0.0512)		TGTCTTCTTCGTCATCTTCTC	0.597000													78	114					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31382762	31382762	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:31382762T>C	ENST00000268296.4	+	16	2070	c.1949T>C	c.(1948-1950)gTa>gCa	p.V650A	ITGAX_ENST00000562522.1_Missense_Mutation_p.V650A	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	650					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						CAGACCCTGGTACAGTCCAAC	0.582000													41	38					0	0	1	0	0
TRIM62	55223	broad.mit.edu	37	1	33625365	33625365	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:33625365C>A	ENST00000291416.5	-	3	918	c.685G>T	c.(685-687)Gcc>Tcc	p.A229S	TRIM62_ENST00000485148.1_5'UTR|TRIM62_ENST00000543586.1_Missense_Mutation_p.A108S	NM_018207.2	NP_060677.2	Q9BVG3	TRI62_HUMAN	tripartite motif containing 62	229						intracellular	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0393)				AGGATCTGGGCTCCCTCCTGG	0.677000													42	55					3.61848e-18	3.95686e-18	1	1	0
LUZP4	51213	broad.mit.edu	37	X	114536597	114536597	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:114536597T>C	ENST00000451986.2	+	2	165	c.5T>C	c.(4-6)cTg>cCg	p.L2P	LUZP4_ENST00000371920.3_Silent_p.A44A			Q9P127	LUZP4_HUMAN	leucine zipper protein 4	0						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						GGACAAATGCTGAAGAAGAAA	0.333000													52	94					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128812	45128812	+	RNA	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:45128812C>T	ENST00000575173.1	-	0	418																											AGTCCTGTTTCTGTGTGGATT	0.373000													5	31					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162514	96162514	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:96162514G>A	ENST00000225235.4	+	1	254	c.144G>A	c.(142-144)ccG>ccA	p.P48P		NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12	48						intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CTGTGGAGCCGCCggaggagg	0.726000													4	9					0	0	1	0	0
RUSC2	9853	broad.mit.edu	37	9	35555086	35555086	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:35555086C>T	ENST00000455600.1	+	3	2613	c.2044C>T	c.(2044-2046)Cgc>Tgc	p.R682C		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	682						cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			ACCAGTCCTTCGCTACAGCAA	0.577000													71	91					0	0	1	0	0
MTSS1L	92154	broad.mit.edu	37	16	70698625	70698625	+	Missense_Mutation	SNP	C	C	A	rs139508787		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:70698625C>A	ENST00000338779.6	-	14	1621	c.1347G>T	c.(1345-1347)atG>atT	p.M449I	FLJ00418_ENST00000597002.1_De_novo_Start_InFrame	NM_138383.2	NP_612392.1	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	449					filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			breast(1)|central_nervous_system(2)|endometrium(1)|liver(1)|lung(1)|skin(1)	7						GCGTCAGCACCATGGCCAGGT	0.667000													10	19					6.40141e-05	6.54317e-05	1	1	0
LCE1B	353132	broad.mit.edu	37	1	152784988	152784988	+	Silent	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:152784988C>A	ENST00000360090.3	+	1	542	c.66C>A	c.(64-66)ccC>ccA	p.P22P		NM_178349.1	NP_848126.1	Q5T7P3	LCE1B_HUMAN	late cornified envelope 1B	22	Pro-rich.				keratinization					breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|skin(2)	18	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			agtgccctcccaagtgccTCA	0.617000													47	76					4.10826e-27	4.59559e-27	1	1	0
TCF4	6925	broad.mit.edu	37	18	52896149	52896149	+	Missense_Mutation	SNP	T	T	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:52896149T>G	ENST00000354452.3	-	18	2419	c.1808A>C	c.(1807-1809)aAg>aCg	p.K603T	TCF4_ENST00000561992.1_Missense_Mutation_p.K469T|TCF4_ENST00000561831.3_Missense_Mutation_p.K439T|TCF4_ENST00000398339.1_Missense_Mutation_p.K705T|TCF4_ENST00000537578.1_Missense_Mutation_p.K579T|TCF4_ENST00000565018.2_Missense_Mutation_p.K603T|TCF4_ENST00000540999.1_Missense_Mutation_p.K575T|TCF4_ENST00000566279.1_Missense_Mutation_p.K543T|TCF4_ENST00000537856.3_Missense_Mutation_p.K469T|TCF4_ENST00000457482.3_Missense_Mutation_p.K443T|TCF4_ENST00000567880.1_Missense_Mutation_p.K539T|TCF4_ENST00000564228.1_Missense_Mutation_p.K528T|TCF4_ENST00000568673.1_Missense_Mutation_p.K579T|TCF4_ENST00000568740.1_Missense_Mutation_p.K574T|TCF4_ENST00000356073.4_Missense_Mutation_p.K599T|TCF4_ENST00000570287.2_Missense_Mutation_p.K439T|TCF4_ENST00000564403.2_Missense_Mutation_p.K609T|TCF4_ENST00000570177.2_Missense_Mutation_p.K469T|TCF4_ENST00000544241.2_Missense_Mutation_p.K532T|TCF4_ENST00000564999.1_Missense_Mutation_p.K599T|TCF4_ENST00000566286.1_Missense_Mutation_p.K596T|TCF4_ENST00000543082.1_Missense_Mutation_p.K557T	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	599	Helix-loop-helix motif.				positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		GGTCTGGGGCTTGTCACTCTT	0.617000													35	63					0	0	1	0	0
ZFAND2B	130617	broad.mit.edu	37	2	220073024	220073024	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:220073024G>A	ENST00000409594.1	+	5	676	c.481G>A	c.(481-483)Gtc>Atc	p.V161I	ZFAND2B_ENST00000409206.1_Missense_Mutation_p.V161I|ZFAND2B_ENST00000409217.1_Missense_Mutation_p.V161I|ZFAND2B_ENST00000444522.2_Missense_Mutation_p.V161I|ZFAND2B_ENST00000409097.1_Missense_Mutation_p.V161I|ZFAND2B_ENST00000289528.5_Missense_Mutation_p.V161I|ZFAND2B_ENST00000409336.1_Missense_Mutation_p.V161I			Q8WV99	ZFN2B_HUMAN	zinc finger, AN1-type domain 2B	161						endoplasmic reticulum	protein binding|zinc ion binding			endometrium(2)|kidney(4)|lung(4)|upper_aerodigestive_tract(1)	11		Renal(207;0.0915)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TACAAGCACTGTCCCCAGCCC	0.547000													22	21					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76889125	76889125	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:76889125T>C	ENST00000373344.5	-	18	5099	c.4885A>G	c.(4885-4887)Aat>Gat	p.N1629D	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Missense_Mutation_p.N1591D	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1629	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	AAAGCAGTATTAAGAGGACAA	0.343000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						26	41					0	0	1	0	0
KIAA1644	85352	broad.mit.edu	37	22	44681537	44681537	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:44681537T>C	ENST00000381176.4	-	4	502	c.370A>G	c.(370-372)Aac>Gac	p.N124D		NM_001099294.1	NP_001092764.1	Q3SXP7	K1644_HUMAN	KIAA1644	124						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9		all_neural(38;0.0762)|Ovarian(80;0.105)|Glioma(61;0.222)				ATGTCGTAGTTCATTGCCGAG	0.557000													26	266					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49421827	49421827	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:49421827C>T	ENST00000301067.7	-	46	14479	c.14480G>A	c.(14479-14481)gGc>gAc	p.G4827D		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TGGCTCAGTGCCTGCCCGGGC	0.607000													21	27					0	0	1	0	0
MC1R	4157	broad.mit.edu	37	16	89985820	89985820	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:89985820A>G	ENST00000555427.1	+	3	2457	c.154A>G	c.(154-156)Agc>Ggc	p.S52G	MC1R_ENST00000555147.1_Missense_Mutation_p.S52G|TUBB3_ENST00000556922.1_Missense_Mutation_p.S52G					melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	11		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GGGGCTGGTGAGCTTGGTGGA	0.642000									Melanoma, Familial Clustering of				50	71					0	0	1	0	0
P2RY12	0	broad.mit.edu	37	3	151056503	151056503	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:151056503C>T	ENST00000302632.3	-	3	430	c.131G>A	c.(130-132)gGc>gAc	p.G44D	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000491549.1_Intron|MED12L_ENST00000474524.1_Intron	NM_022788.4|NM_176876.2	NP_073625.1|NP_795345.1	Q9H244	P2Y12_HUMAN	purinergic receptor P2Y, G-protein coupled, 12	44					platelet activation	integral to membrane|plasma membrane	guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	17			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)		Clopidogrel(DB00758)|Epoprostenol(DB01240)|Ticlopidine(DB00208)|Treprostinil(DB00374)	CATCGCCAGGCCATTTGTGAT	0.403000													19	36					0	0	1	0	0
NELFA	7469	broad.mit.edu	37	4	1988038	1988038	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:1988038C>T	ENST00000382882.3	-	5	1876	c.759G>A	c.(757-759)ccG>ccA	p.P253P	NELFA_ENST00000542778.1_Silent_p.P107P|NELFA_ENST00000411638.1_Silent_p.P242P	NM_005663.4	NP_005654.3			negative elongation factor complex member A																		TCCTGGAAGGCGGGATGGGGG	0.697000													10	7					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76528916	76528916	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:76528916C>T	ENST00000307431.8	+	15	2572	c.2187C>T	c.(2185-2187)tgC>tgT	p.C729C	CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Silent_p.C733C|CNTNAP4_ENST00000478060.1_Silent_p.C657C|CNTNAP4_ENST00000377504.4_Silent_p.C681C	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	730	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AGGGAAACTGCATTGATTCTC	0.378000													49	85					0	0	1	0	0
PCDHA6	0	broad.mit.edu	37	5	140208727	140208727	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140208727G>A	ENST00000529310.1	+	1	1165	c.1051G>A	c.(1051-1053)Gca>Aca	p.A351T	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.A351T|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTGAGATAGCACTGACTTC	0.488000													91	80					0	0	1	0	0
PLEKHA8P1	0	broad.mit.edu	37	12	45568424	45568424	+	RNA	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:45568424C>A	ENST00000256692.5	-	0	261					NR_037144.1															breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GACAATATTCCCCTACAGAGA	0.488000													23	22					1.85244e-09	1.95734e-09	1	1	0
SLC28A3	64078	broad.mit.edu	37	9	86900965	86900965	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:86900965C>T	ENST00000376238.4	-	13	1391	c.1342G>A	c.(1342-1344)Gcc>Acc	p.A448T	SLC28A3_ENST00000537648.1_Missense_Mutation_p.A379T|RP11-380F14.2_ENST00000419815.1_RNA	NM_001199633.1|NM_022127.2	NP_001186562.1|NP_071410.1	Q9HAS3	S28A3_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 3	448					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			endometrium(2)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						GCGATGTTGGCCACCAGGGAG	0.473000													16	19					0	0	1	0	0
SLC12A4	6560	broad.mit.edu	37	16	67985067	67985067	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:67985067C>T	ENST00000422611.2	-	8	1318	c.1279G>A	c.(1279-1281)Ggc>Agc	p.G427S	SLC12A4_ENST00000576616.1_Missense_Mutation_p.G425S|SLC12A4_ENST00000338335.3_Missense_Mutation_p.G425S|SLC12A4_ENST00000541864.2_Missense_Mutation_p.G394S|SLC12A4_ENST00000537830.2_Missense_Mutation_p.G419S|SLC12A4_ENST00000572037.1_Missense_Mutation_p.G377S|SLC12A4_ENST00000316341.3_Missense_Mutation_p.G425S	NM_001145962.1	NP_001139434.1	Q9UP95	S12A4_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 4	425					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|prostate(4)|skin(2)|urinary_tract(3)	29		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	AAGAAGATGCCGACCAGCACG	0.622000													72	108					0	0	1	0	0
TMEM106A	113277	broad.mit.edu	37	17	41369782	41369782	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:41369782G>A	ENST00000331615.3	+	9	988	c.751G>A	c.(751-753)Gca>Aca	p.A251T	TMEM106A_ENST00000536052.1_Missense_Mutation_p.A204T|TMEM106A_ENST00000541594.1_Missense_Mutation_p.A203T|TMEM106A_ENST00000588659.1_Missense_Mutation_p.A251T|LINC00854_ENST00000427995.1_RNA	NM_145041.1	NP_659478.1	Q96A25	T106A_HUMAN	transmembrane protein 106A	251						integral to membrane				NS(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11		Breast(137;0.0164)		BRCA - Breast invasive adenocarcinoma(366;0.0917)		CCGAGGAAACGCATCTGTGCC	0.577000													127	183					0	0	1	0	0
SLC15A3	51296	broad.mit.edu	37	11	60718781	60718781	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:60718781G>A	ENST00000227880.3	-	1	476	c.243C>T	c.(241-243)ggC>ggT	p.G81G		NM_016582.2	NP_057666.1	Q8IY34	S15A3_HUMAN	solute carrier family 15 (oligopeptide transporter), member 3	81					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)	17						GGTAGGAGGCGCCCAGGAATA	0.701000													4	3					0	0	1	0	0
HBS1L	10767	broad.mit.edu	37	6	135287507	135287507	+	Missense_Mutation	SNP	C	C	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:135287507C>G	ENST00000367837.5	-	17	2209	c.2003G>C	c.(2002-2004)cGt>cCt	p.R668P	HBS1L_ENST00000367826.2_Missense_Mutation_p.R626P|HBS1L_ENST00000415177.2_Missense_Mutation_p.R603P|HBS1L_ENST00000527578.1_Missense_Mutation_p.R504P|HBS1L_ENST00000367824.4_Missense_Mutation_p.R504P|HBS1L_ENST00000445176.2_Missense_Mutation_p.R392P	NM_001145158.1|NM_006620.3	NP_001138630.1|NP_006611.1	Q9Y450	HBS1L_HUMAN	HBS1-like (S. cerevisiae)	668					signal transduction		GTP binding|GTPase activity|translation elongation factor activity	p.R668P(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	20	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0046)|GBM - Glioblastoma multiforme(68;0.00702)		ACCACCGTAACGTAGCATGAA	0.378000													45	126					0	0	1	0	0
SLC39A1	27173	broad.mit.edu	37	1	153932984	153932984	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:153932984G>T	ENST00000368623.3	-	3	1324	c.565C>A	c.(565-567)Ctc>Atc	p.L189I	SLC39A1_ENST00000537590.1_Missense_Mutation_p.L87I|SLC39A1_ENST00000356205.4_Missense_Mutation_p.L189I|SLC39A1_ENST00000368621.1_Missense_Mutation_p.L189I|SLC39A1_ENST00000310483.6_Missense_Mutation_p.L189I			Q9NY26	S39A1_HUMAN	solute carrier family 39 (zinc transporter), member 1	189						endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	zinc ion transmembrane transporter activity			kidney(2)|large_intestine(2)|lung(7)|urinary_tract(1)	12	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)	Colorectal(1306;0.019)		ACGGAGTGGAGGGCCAGGGAG	0.677000													31	33					9.78306e-22	1.08194e-21	1	1	0
PPP1R16B	26051	broad.mit.edu	37	20	37546949	37546949	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:37546949T>C	ENST00000299824.1	+	11	1533	c.1344T>C	c.(1342-1344)caT>caC	p.H448H	PPP1R16B_ENST00000373331.2_Silent_p.H406H	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	448					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				GGAAGGTGCATGAGGTGCCTG	0.627000													11	349					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38651194	38651194	+	RNA	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:38651194T>C	ENST00000494540.1	+	0	341					NR_003086.1																						TTAGACCGTATATATCTAAAT	0.358000													23	49					0	0	1	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58850389	58850389	+	Silent	SNP	G	G	A	rs140941763	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:58850389G>A	ENST00000329665.4	+	3	1320	c.1173G>A	c.(1171-1173)caG>caA	p.Q391Q		NM_181846.2	NP_862829.1	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	391					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|pancreas(1)|prostate(2)	16		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		CCTTCAGCCAGAGCACGCACC	0.637000													46	64					0	0	1	0	0
PODN	127435	broad.mit.edu	37	1	53543382	53543382	+	Missense_Mutation	SNP	C	C	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:53543382C>G	ENST00000371500.3	+	9	1192	c.851C>G	c.(850-852)cCg>cGg	p.P284R	PODN_ENST00000395871.2_Missense_Mutation_p.P161R|RP11-334A14.5_ENST00000447867.1_RNA|PODN_ENST00000312553.5_Missense_Mutation_p.P303R	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	255					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AAGATCCCCCCGGGGGCCTTC	0.612000													59	142					0	0	1	0	0
SLC5A6	8884	broad.mit.edu	37	2	27423872	27423872	+	Silent	SNP	G	G	A	rs140378947		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:27423872G>A	ENST00000310574.3	-	16	2231	c.1758C>T	c.(1756-1758)taC>taT	p.Y586Y	SLC5A6_ENST00000408041.1_Silent_p.Y586Y	NM_021095.2	NP_066918.2	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6	586					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|ovary(3)|prostate(1)|skin(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	CTACCTGGCCGTAGCTCCTGC	0.592000													4	23					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124418011	124418011	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:124418011T>C	ENST00000409039.3	+	76	13101	c.13076T>C	c.(13075-13077)gTg>gCg	p.V4359A	DNAH10OS_ENST00000514254.2_Intron|CCDC92_ENST00000544798.1_Intron	NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4359					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TTCACACAAGTGACCAAGTTC	0.592000													53	52					0	0	1	0	0
ZSWIM8	23053	broad.mit.edu	37	10	75550867	75550867	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:75550867A>G	ENST00000604729.1	+	8	1373	c.1076A>G	c.(1075-1077)aAg>aGg	p.K359R	ZSWIM8_ENST00000603114.1_Missense_Mutation_p.K359R|ZSWIM8_ENST00000604524.1_Missense_Mutation_p.K359R|ZSWIM8_ENST00000605216.1_Missense_Mutation_p.K359R|ZSWIM8_ENST00000398706.2_Missense_Mutation_p.K359R					zinc finger, SWIM-type containing 8																		GAGATGTTCAAGCGGAGGGAC	0.607000													23	65					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31594934	31594934	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:31594934C>T	ENST00000376033.2	+	11	1483	c.1249C>T	c.(1249-1251)Cgg>Tgg	p.R417W	PRRC2A_ENST00000376007.4_Missense_Mutation_p.R417W	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	417	2 X type B repeats.|4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						CCCACCTCACCGGGGCCCCGC	0.652000													41	30					0	0	1	0	0
C9orf84	158401	broad.mit.edu	37	9	114543240	114543240	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:114543240G>A	ENST00000374287.3	-	4	295	c.35C>T	c.(34-36)gCa>gTa	p.A12V	C9orf84_ENST00000318737.4_Missense_Mutation_p.A12V|C9orf84_ENST00000374283.5_Missense_Mutation_p.A76V			Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84	12										breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						AAAGAAACTTGCTTTCCATTG	0.353000													31	37					0	0	1	0	0
CAPN9	10753	broad.mit.edu	37	1	230907846	230907846	+	Splice_Site	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:230907846G>A	ENST00000354537.1	+	7	957		c.e7+1		CAPN9_ENST00000366666.2_Splice_Site|CAPN9_ENST00000271971.2_Splice_Site|RP11-99J16__A.2_ENST00000412344.1_RNA	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9						digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				GGAGCGACAGGTCAGTCACCC	0.597000													37	57					0	0	1	0	0
RBM25	58517	broad.mit.edu	37	14	73577560	73577560	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:73577560C>T	ENST00000261973.7	+	15	1999	c.1714C>T	c.(1714-1716)Cgc>Tgc	p.R572C	RBM25_ENST00000532483.1_3'UTR|RBM25_ENST00000527432.1_Missense_Mutation_p.R572C	NM_021239.2	NP_067062.1	P49756	RBM25_HUMAN	RNA binding motif protein 25	572	Glu-rich.|Necessary for nuclear speckle localization.			RRRQ -> EAQE (in Ref. 8; AAC41999).	apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		GGCTGAGAGGCGCAGGCAGCC	0.388000													7	18					0	0	1	0	0
CACNB2	783	broad.mit.edu	37	10	18787305	18787305	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:18787305G>A	ENST00000396576.2	+	3	691	c.190G>A	c.(190-192)Gtt>Att	p.V64I	CACNB2_ENST00000377331.2_Missense_Mutation_p.V91I|CACNB2_ENST00000377319.3_Missense_Mutation_p.V64I|CACNB2_ENST00000377328.1_Missense_Mutation_p.V119I|CACNB2_ENST00000377329.4_Missense_Mutation_p.V65I|CACNB2_ENST00000352115.6_Missense_Mutation_p.V119I|CACNB2_ENST00000324631.7_Missense_Mutation_p.V119I|CACNB2_ENST00000377315.4_Missense_Mutation_p.V71I|CACNB2_ENST00000282343.8_Missense_Mutation_p.V91I	NM_000724.3	NP_000715.2	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2 subunit	119					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGCATTTGCGGTTCGGACAAA	0.448000													20	32					0	0	1	0	0
RASAL3	64926	broad.mit.edu	37	19	15572069	15572069	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:15572069C>A	ENST00000343625.6	-	4	584	c.504G>T	c.(502-504)gaG>gaT	p.E168D		NM_022904.1	NP_075055.1	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	168					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|skin(1)	18						GGATGCTGCCCTCGGAGCTAG	0.627000													13	21					9.31168e-06	9.57367e-06	1	1	0
FAAH2	158584	broad.mit.edu	37	X	57337042	57337042	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:57337042A>G	ENST00000374900.4	+	3	412	c.292A>G	c.(292-294)Aag>Gag	p.K98E		NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	98				K -> R (in Ref. 1; BAB71007).		integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						GGAAGCGATGAAGGAGGCTCA	0.393000										HNSCC(52;0.14)			20	30					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196922833	196922833	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:196922833G>A	ENST00000312428.6	-	2	123	c.23C>T	c.(22-24)tCg>tTg	p.S8L	DNAH7_ENST00000410072.1_Missense_Mutation_p.S8L	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	8	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TTTGCTGGCCGATTTATCCTG	0.313000													31	33					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20864412	20864412	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:20864412T>C	ENST00000381552.1	+	5	865	c.497T>C	c.(496-498)gTt>gCt	p.V166A	SLCO1C1_ENST00000545102.1_Missense_Mutation_p.V48A|SLCO1C1_ENST00000540354.1_Missense_Mutation_p.V166A|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.V166A|SLCO1C1_ENST00000266509.2_Missense_Mutation_p.V166A			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	166					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					CCAGTTTCAGTTATGGAAAAA	0.343000													24	40					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139221883	139221883	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:139221883C>A	ENST00000274710.3	+	15	2345	c.2140C>A	c.(2140-2142)Ctc>Atc	p.L714I		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	714					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATATCCACCTCCTGGCTAT	0.473000													21	52					1.10513e-12	1.18051e-12	1	1	0
ZDHHC7	55625	broad.mit.edu	37	16	85015539	85015539	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:85015539C>A	ENST00000313732.4	-	4	729	c.377G>T	c.(376-378)gGg>gTg	p.G126V	ZDHHC7_ENST00000569488.1_Intron|ZDHHC7_ENST00000564466.1_Missense_Mutation_p.G163V	NM_017740.2	NP_060210.2	Q9NXF8	ZDHC7_HUMAN	zinc finger, DHHC-type containing 7	126						integral to membrane	acyltransferase activity|protein binding|zinc ion binding			large_intestine(6)|lung(4)	10						GATGACTTCCCCGGGCTTCAG	0.527000													87	100					3.98749e-38	4.4949e-38	1	1	0
CPAMD8	27151	broad.mit.edu	37	19	17108016	17108016	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:17108016C>T	ENST00000443236.1	-	11	1172	c.1141G>A	c.(1141-1143)Gat>Aat	p.D381N	CPAMD8_ENST00000388925.4_Missense_Mutation_p.D334N	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	334						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GTGGAGTCATCGAACGCGACC	0.642000													17	25					0	0	1	0	0
NR4A1	0	broad.mit.edu	37	12	52451181	52451181	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:52451181G>A	ENST00000545748.1	+	7	2564	c.1569G>A	c.(1567-1569)gtG>gtA	p.V523V	NR4A1_ENST00000550082.1_Silent_p.V482V|NR4A1_ENST00000394825.1_Silent_p.V469V|NR4A1_ENST00000394824.2_Silent_p.V469V|NR4A1_ENST00000243050.1_Silent_p.V469V|NR4A1_ENST00000360284.3_Silent_p.V482V			P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	469					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)	16				BRCA - Breast invasive adenocarcinoma(357;0.0967)		CAGGCCTGGTGCTACACCGGC	0.602000													30	49					0	0	1	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150531877	150531877	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:150531877C>T	ENST00000271643.4	+	17	3114	c.2878C>T	c.(2878-2880)Cct>Tct	p.P960S	ADAMTSL4_ENST00000369039.5_Missense_Mutation_p.P983S|ADAMTSL4_ENST00000369038.2_Missense_Mutation_p.P960S	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	960	TSP type-1 5.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CCCCAGGCCCCCTGCCCTGCA	0.617000											OREG0013787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	53					0	0	1	0	0
TRO	7216	broad.mit.edu	37	X	54948702	54948702	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:54948702G>T	ENST00000173898.7	+	2	135	c.23G>T	c.(22-24)gGa>gTa	p.G8V	TRO_ENST00000420798.2_Intron|TRO_ENST00000375041.2_Missense_Mutation_p.G8V|TRO_ENST00000319167.8_Missense_Mutation_p.G8V|TRO_ENST00000375022.4_Missense_Mutation_p.G8V|TRO_ENST00000399736.1_Missense_Mutation_p.G8V|TRO_ENST00000484031.1_3'UTR	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	8					embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						AATGACTACGGATATAGGGTG	0.532000													8	11					1.12685e-05	1.1572e-05	1	1	0
DGKB	1607	broad.mit.edu	37	7	14217687	14217687	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:14217687G>A	ENST00000403951.2	-	24	2634	c.2215C>T	c.(2215-2217)Cgg>Tgg	p.R739W	DGKB_ENST00000258767.5_Missense_Mutation_p.R739W|DGKB_ENST00000444700.2_Missense_Mutation_p.R720W|DGKB_ENST00000399322.3_Missense_Mutation_p.R739W|DGKB_ENST00000407950.1_Missense_Mutation_p.R731W|DGKB_ENST00000406247.3_Missense_Mutation_p.R739W|DGKB_ENST00000402815.1_Missense_Mutation_p.R738W			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	739					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	TGAGCCAGCCGCCGGCCAGCA	0.507000													39	61					0	0	1	0	0
FOXG1	2290	broad.mit.edu	37	14	29237048	29237048	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:29237048C>T	ENST00000382535.3	+	2	932	c.563C>T	c.(562-564)gCg>gTg	p.A188V	FOXG1_ENST00000313071.4_Missense_Mutation_p.A188V			P55316	FOXG1_HUMAN	forkhead box G1	188					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		AGCTACAACGCGCTCATCATG	0.612000													16	29					0	0	1	0	0
MAD1L1	8379	broad.mit.edu	37	7	1976422	1976422	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:1976422G>A	ENST00000406869.1	-	17	2265	c.1708C>T	c.(1708-1710)Cga>Tga	p.R570*	MAD1L1_ENST00000402746.1_Nonsense_Mutation_p.R478*|MAD1L1_ENST00000265854.7_Nonsense_Mutation_p.R570*|MAD1L1_ENST00000399654.2_Nonsense_Mutation_p.R570*			Q9Y6D9	MD1L1_HUMAN	MAD1 mitotic arrest deficient-like 1 (yeast)	570					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(5)	36		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		CCGCGCAGTCGCTCGCACTCC	0.692000													8	11					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132306088	132306088	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:132306088G>A	ENST00000331898.7	-	6	1407	c.829C>T	c.(829-831)Cgc>Tgc	p.R277C	OPCML_ENST00000524381.1_Missense_Mutation_p.R270C|OPCML_ENST00000529038.1_5'UTR|OPCML_ENST00000541867.1_Missense_Mutation_p.R277C|OPCML_ENST00000374778.4_Missense_Mutation_p.R236C	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	277	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		GTGGACATGCGGCCTTTGTTT	0.463000													29	62					0	0	1	0	0
SNAPC4	6621	broad.mit.edu	37	9	139273254	139273254	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:139273254G>T	ENST00000298532.2	-	21	3393	c.3025C>A	c.(3025-3027)Ctg>Atg	p.L1009M		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	1009	Pro-rich.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CCGGGGCCCAGGGCAGGGGCT	0.682000													11	21					0.00010058	0.000102688	1	1	0
KLKB1	3818	broad.mit.edu	37	4	187159508	187159508	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:187159508T>C	ENST00000264690.6	+	6	774	c.587T>C	c.(586-588)cTt>cCt	p.L196P	KLKB1_ENST00000513864.1_Missense_Mutation_p.L196P	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	196					blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		CCCTGTGCCCTTTCAGAAATT	0.498000													32	45					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12246317	12246317	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:12246317C>T	ENST00000256194.4	+	13	1926	c.1638C>T	c.(1636-1638)cgC>cgT	p.R546R	MICAL2_ENST00000342902.5_Silent_p.R546R|MICAL2_ENST00000379612.3_Silent_p.R546R|MICAL2_ENST00000537344.1_Silent_p.R546R|MICAL2_ENST00000527546.1_Silent_p.R546R	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	546	CH.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		CATCCTGGCGCAGTGGGTTGG	0.637000													32	23					0	0	1	0	0
RNF186	54546	broad.mit.edu	37	1	20141295	20141295	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:20141295G>A	ENST00000375121.2	-	1	476	c.300C>T	c.(298-300)cgC>cgT	p.R100R	RP11-91K11.2_ENST00000454736.1_RNA	NM_019062.1	NP_061935.1	Q9NXI6	RN186_HUMAN	ring finger protein 186	100						integral to membrane	zinc ion binding			kidney(1)|lung(3)|urinary_tract(1)	5		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;7.77e-05)|Kidney(64;0.000162)|GBM - Glioblastoma multiforme(114;0.00036)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCTCATGGTCGCGCAGGCTGC	0.667000													33	53					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176004718	176004718	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:176004718G>A	ENST00000510636.1	+	14	1705	c.1431G>A	c.(1429-1431)agG>agA	p.R477R	CDHR2_ENST00000506348.1_Silent_p.R477R|CDHR2_ENST00000261944.5_Silent_p.R477R	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	477	Cadherin 4.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						ATGACCACAGGCCCACGTTTC	0.607000													27	59					0	0	1	0	0
OR1A1	8383	broad.mit.edu	37	17	3119791	3119791	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:3119791C>T	ENST00000304094.1	+	1	877	c.877C>T	c.(877-879)Cgg>Tgg	p.R293W		NM_014565.2	NP_055380.2	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A, member 1	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R293W(2)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	23						TCTGAGAAATCGGGACATGAA	0.468000													56	92					0	0	1	0	0
RASSF7	8045	broad.mit.edu	37	11	563280	563280	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:563280C>A	ENST00000397583.3	+	4	1347	c.914C>A	c.(913-915)cCg>cAg	p.P305Q	RASSF7_ENST00000454668.2_Missense_Mutation_p.P305Q|RASSF7_ENST00000431809.1_Missense_Mutation_p.P305Q|RASSF7_ENST00000397582.3_Missense_Mutation_p.P305Q|RASSF7_ENST00000344375.4_Missense_Mutation_p.P305Q	NM_003475.3	NP_003466.1	Q02833	RASF7_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 7	305	Pro-rich.				regulation of transcription, DNA-dependent|signal transduction	nucleus	DNA binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|skin(3)	8		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCGCTGCCACCGCCCCCACGG	0.682000													7	14					2.0095e-06	2.08067e-06	1	1	0
RNPEPL1	57140	broad.mit.edu	37	2	241517019	241517019	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:241517019T>C	ENST00000270357.3	+	11	1788	c.1195T>C	c.(1195-1197)Tca>Cca	p.S399P	RNPEPL1_ENST00000464550.1_3'UTR	NM_018226.4	NP_060696.4	Q9HAU8	RNPL1_HUMAN	arginyl aminopeptidase (aminopeptidase B)-like 1	399					leukotriene biosynthetic process|proteolysis		aminopeptidase activity|metallopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	13		all_epithelial(40;1.13e-11)|Breast(86;0.000169)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.204)|Melanoma(123;0.238)		Epithelial(32;3.05e-31)|all cancers(36;8.2e-29)|OV - Ovarian serous cystadenocarcinoma(60;8.55e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.12e-06)|Lung(119;0.00168)|Colorectal(34;0.005)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.0322)		CCTGCAGATGTCACGCATGTA	0.697000													26	31					0	0	1	0	0
RTKN2	219790	broad.mit.edu	37	10	63995969	63995969	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:63995969G>A	ENST00000373789.3	-	6	638	c.542C>T	c.(541-543)aCa>aTa	p.T181I	RTKN2_ENST00000315289.2_5'UTR|RTKN2_ENST00000395265.1_Missense_Mutation_p.T181I	NM_145307.2	NP_660350.2	Q8IZC4	RTKN2_HUMAN	rhotekin 2	181					signal transduction	intracellular				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(12;0.0297)|all_hematologic(501;0.215)					AGATTCTTCTGTACAGCAACT	0.348000													18	41					0	0	1	0	0
TIMM10B	26515	broad.mit.edu	37	11	6503065	6503065	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:6503065G>T	ENST00000254616.6	+	2	188	c.118G>T	c.(118-120)Gct>Tct	p.A40S	TIMM10B_ENST00000530751.1_Intron|TIMM10B_ENST00000472836.1_Missense_Mutation_p.A40S	NM_012192.3	NP_036324.1			translocase of inner mitochondrial membrane 10 homolog B (yeast)																		GCACCACCGAGCTCTGGACGC	0.572000													29	42					2.12542e-12	2.26763e-12	1	1	0
ALPK3	57538	broad.mit.edu	37	15	85383002	85383002	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:85383002A>G	ENST00000258888.5	+	5	1265	c.1098A>G	c.(1096-1098)tcA>tcG	p.S366S		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	366	Ig-like 1.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGTCCTGCTCAGGGGTCCTGG	0.607000													44	64					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25990452	25990452	+	Splice_Site	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:25990452T>C	ENST00000435504.4	-	8	1068	c.775_splice	c.e8+1	p.R259_splice	ASXL2_ENST00000336112.4_Splice_Site_p.R231_splice|ASXL2_ENST00000404843.1_5'UTR|ASXL2_ENST00000272341.4_5'UTR			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding	p.R259*(1)		NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCAAACTTACTGGTATGGAGT	0.373000													15	29					0	0	1	0	0
SIM1	6492	broad.mit.edu	37	6	100896035	100896035	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:100896035G>A	ENST00000369208.3	-	8	1619	c.837C>T	c.(835-837)tgC>tgT	p.C279C	SIM1_ENST00000262901.4_Silent_p.C279C			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	279	PAS 2.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		AATGGTGCGCGCAGCGCAGGT	0.622000													12	28					0	0	1	0	0
TBC1D17	79735	broad.mit.edu	37	19	50381767	50381767	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:50381767C>A	ENST00000221543.5	+	3	432	c.133C>A	c.(133-135)Ctc>Atc	p.L45I	TBC1D17_ENST00000598789.1_3'UTR|TBC1D17_ENST00000535102.2_Missense_Mutation_p.L12I	NM_024682.2	NP_078958.2	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	45						intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CAATGACGTCCTCCTGCACTG	0.537000													36	36					6.1244e-12	6.52625e-12	1	1	0
FBXW5	54461	broad.mit.edu	37	9	139836499	139836499	+	Splice_Site	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:139836499G>A	ENST00000325285.3	-	6	1174	c.1096_splice	c.e6+1	p.I365_splice	FBXW5_ENST00000483559.1_5'UTR	NM_018998.3	NP_061871.1	Q969U6	FBXW5_HUMAN	F-box and WD repeat domain containing 5	365							catalytic activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	12	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		GGGGTGTACCGATCTGGTGTG	0.662000													8	18					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105957717	105957717	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:105957717G>A	ENST00000357060.3	-	9	1290	c.1175C>T	c.(1174-1176)gCa>gTa	p.A392V	WDR96_ENST00000369720.1_Missense_Mutation_p.A323V|WDR96_ENST00000278064.2_Missense_Mutation_p.A323V|WDR96_ENST00000428666.1_Missense_Mutation_p.A393V	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	392										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						AAAGTCAATTGCCTGAAATTT	0.343000													38	27					0	0	1	0	0
CTD-3074O7.11	0	broad.mit.edu	37	11	66298469	66298469	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:66298469G>A	ENST00000419755.3	+	15	1767	c.1689G>A	c.(1687-1689)gcG>gcA	p.A563A	BBS1_ENST00000455748.2_Silent_p.A429A|BBS1_ENST00000393994.2_Silent_p.A397A|ZDHHC24_ENST00000526986.1_Intron|BBS1_ENST00000318312.7_Silent_p.A526A																							ACAACGAGGCGCTCTATTCCC	0.587000													29	43					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	17126304	17126304	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:17126304T>C	ENST00000377833.4	-	17	2332	c.2267A>G	c.(2266-2268)cAa>cGa	p.Q756R		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	756	CUB 3.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACTCTGGCATTGCAGCTCCAC	0.443000													38	41					0	0	1	0	0
NFE2L3	9603	broad.mit.edu	37	7	26192151	26192151	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:26192151C>T	ENST00000056233.3	+	1	292	c.33C>T	c.(31-33)ggC>ggT	p.G11G		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	11					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						GGTCGGCCGGCGGCGGCCTCC	0.756000													13	17					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99439573	99439573	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:99439573G>A	ENST00000397899.2	-	7	1494	c.1163C>T	c.(1162-1164)gCg>gTg	p.A388V		NM_207362.2	NP_997245.2			KIAA1211-like																		CACCTCCTCCGCCTTGTCCGT	0.751000													15	14					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111423966	111423966	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:111423966G>A	ENST00000428084.1	-	34	3743	c.3471C>T	c.(3469-3471)ggC>ggT	p.G1157G	DOCK4_ENST00000437633.1_Silent_p.G1148G|DOCK4_ENST00000494651.2_Silent_p.G31G			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1148	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TTAATGAAACGCCACTTTCCC	0.408000													6	7					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47243577	47243577	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:47243577G>T	ENST00000300404.2	+	9	1295	c.1236G>T	c.(1234-1236)gaG>gaT	p.E412D	B4GALNT2_ENST00000504681.1_Missense_Mutation_p.E326D|B4GALNT2_ENST00000393354.2_Missense_Mutation_p.E352D	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	412					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			CCAAGATTGAGGTGCTGGTGG	0.502000													31	38					5.77227e-19	6.33577e-19	1	1	0
ABL2	27	broad.mit.edu	37	1	179078368	179078368	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:179078368C>T	ENST00000502732.1	-	12	2237	c.2034G>A	c.(2032-2034)caG>caA	p.Q678Q	ABL2_ENST00000504405.1_Silent_p.Q642Q|ABL2_ENST00000344730.3_Silent_p.Q663Q|ABL2_ENST00000511413.1_Silent_p.Q678Q|ABL2_ENST00000367623.4_Silent_p.Q657Q|ABL2_ENST00000408940.3_Silent_p.Q642Q|ABL2_ENST00000507173.1_Silent_p.Q657Q|ABL2_ENST00000512653.1_Silent_p.Q663Q	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	678					axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	TCTTATGGGGCTGATTCTCCA	0.512000			T	ETV6	AML								86	179					0	0	1	0	0
ZNF785	146540	broad.mit.edu	37	16	30594122	30594122	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:30594122A>G	ENST00000395216.2	-	3	1136	c.977T>C	c.(976-978)cTc>cCc	p.L326P	AC002310.7_ENST00000492040.1_RNA|AC002310.7_ENST00000486926.1_RNA|ZNF785_ENST00000470110.1_Missense_Mutation_p.L311P	NM_152458.6	NP_689671.2	A8K8V0	ZN785_HUMAN	zinc finger protein 785	326					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	9						ACTGAGGAGGAGGGAAGAATA	0.647000													42	61					0	0	1	0	0
C11orf65	160140	broad.mit.edu	37	11	108332220	108332220	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:108332220A>G	ENST00000525729.1	-	2	136	c.67T>C	c.(67-69)Tgg>Cgg	p.W23R	C11orf65_ENST00000393084.1_Missense_Mutation_p.W23R|C11orf65_ENST00000529391.1_Missense_Mutation_p.W23R			Q8NCR3	CK065_HUMAN	chromosome 11 open reading frame 65	23										endometrium(1)|large_intestine(3)|lung(4)|ovary(2)	10		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		AAACTTTTCCAGGCCTGCTGA	0.308000													63	83					0	0	1	0	0
FAM53B	9679	broad.mit.edu	37	10	126311887	126311887	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:126311887C>A	ENST00000337318.3	-	5	1404	c.1193G>T	c.(1192-1194)cGg>cTg	p.R398L	FAM53B_ENST00000392754.3_Missense_Mutation_p.R398L|RP11-12J10.3_ENST00000494792.1_Intron	NM_014661.3	NP_055476.3	Q14153	FA53B_HUMAN	family with sequence similarity 53, member B	398										cervix(1)|lung(5)|ovary(2)|pancreas(1)	9		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		CCCGCGGTCCCGCCAGGCTGC	0.672000													65	42					2.79145e-41	3.15884e-41	1	1	0
EI24	9538	broad.mit.edu	37	11	125453541	125453541	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:125453541C>T	ENST00000278903.6	+	12	1225	c.983C>T	c.(982-984)cCg>cTg	p.P328L	EI24_ENST00000530985.1_3'UTR|STT3A-AS1_ENST00000530526.1_RNA|STT3A-AS1_ENST00000532714.1_RNA|EI24_ENST00000343678.4_3'UTR	NM_004879.3	NP_004870.3	O14681	EI24_HUMAN	etoposide induced 2.4	329					apoptosis|autophagy|induction of apoptosis|negative regulation of cell growth	endoplasmic reticulum membrane|integral to membrane|nuclear membrane				large_intestine(1)|lung(9)|ovary(1)	11	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.64e-07)|OV - Ovarian serous cystadenocarcinoma(99;0.0975)		TCACCGCATCCGTCGCCTGCC	0.547000													14	9					0	0	1	0	0
MFI2	4241	broad.mit.edu	37	3	196730857	196730857	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:196730857T>C	ENST00000296350.5	-	15	2165	c.2052A>G	c.(2050-2052)ggA>ggG	p.G684G	MFI2-AS1_ENST00000437064.1_RNA|MFI2-AS1_ENST00000415244.1_RNA|MFI2-AS1_ENST00000424769.1_RNA|MFI2-AS1_ENST00000414354.1_RNA	NM_005929.5	NP_005920.2	P08582	TRFM_HUMAN	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	684	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(1)	20	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		TGGTTTTCTCTCCGACAGGCA	0.607000													184	242					0	0	1	0	0
APOBEC3F	200316	broad.mit.edu	37	22	39441204	39441204	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:39441204G>A	ENST00000308521.5	+	3	787	c.430G>A	c.(430-432)Gtg>Atg	p.V144M	APOBEC3G_ENST00000452957.2_Intron	NM_145298.5	NP_660341.2	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F	149					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|skin(2)	16	Melanoma(58;0.04)					AGGGGCCCGCGTGAAGATTAT	0.597000													36	51					0	0	1	0	0
MANSC1	54682	broad.mit.edu	37	12	12483294	12483294	+	Silent	SNP	C	C	T	rs146158847	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:12483294C>T	ENST00000535902.1	-	4	1526	c.963G>A	c.(961-963)ccG>ccA	p.P321P	MANSC1_ENST00000545735.1_Silent_p.P240P|MANSC1_ENST00000396349.3_Silent_p.P287P			Q9H8J5	MANS1_HUMAN	MANSC domain containing 1	321	Thr-rich.					integral to membrane				breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|stomach(4)	23		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		TTTCTGTAAACGGTATGGTTT	0.458000													44	87					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57918264	57918264	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:57918264C>T	ENST00000564448.1	-	33	3602	c.3542G>A	c.(3541-3543)cGg>cAg	p.R1181Q	CNGB1_ENST00000251102.8_Missense_Mutation_p.R1187Q			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	1187					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						GGGGGGCGTCCGGGGCGCGGG	0.741000													19	35					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124382167	124382167	+	Missense_Mutation	SNP	A	A	T	rs149531312	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:124382167A>T	ENST00000287394.5	-	7	932	c.825T>A	c.(823-825)gaT>gaA	p.D275E	ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	275	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			cttcatcatcatcatcatcat	0.378000													17	18					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104898136	104898136	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:104898136A>G	ENST00000507740.1	+	2	969	c.733A>G	c.(733-735)Agg>Ggg	p.R245G	RIMS2_ENST00000436393.2_Missense_Mutation_p.R215G|RIMS2_ENST00000262231.10_Missense_Mutation_p.R245G|RIMS2_ENST00000406091.3_Missense_Mutation_p.R437G	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	468					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TCCTACCCCCAGGAGGAGTCC	0.468000										HNSCC(12;0.0054)			12	110					0	0	1	0	0
MFN1	55669	broad.mit.edu	37	3	179107816	179107816	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:179107816C>T	ENST00000471841.1	+	17	2163	c.2037C>T	c.(2035-2037)cgC>cgT	p.R679R	MFN1_ENST00000263969.5_Silent_p.R679R|MFN1_ENST00000280653.7_Silent_p.R568R	NM_033540.2	NP_284941.2	Q8IWA4	MFN1_HUMAN	mitofusin 1	679					mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(3)|prostate(1)|urinary_tract(1)	31	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			CTTTTGCTCGCCTGTGCCAAC	0.299000													10	17					0	0	1	0	0
TSTD2	158427	broad.mit.edu	37	9	100367047	100367047	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:100367047T>C	ENST00000341170.4	-	9	1596	c.1214A>G	c.(1213-1215)gAa>gGa	p.E405G	TSTD2_ENST00000375172.2_Missense_Mutation_p.E179G|TSTD2_ENST00000354801.2_Missense_Mutation_p.E145G|TSTD2_ENST00000375165.1_Missense_Mutation_p.E145G	NM_139246.4	NP_640339.4	Q5T7W7	TSTD2_HUMAN	thiosulfate sulfurtransferase (rhodanese)-like domain containing 2	405										large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	15						AGCATAGCGTTCATCAAAAAC	0.468000													49	66					0	0	1	0	0
FANCE	2178	broad.mit.edu	37	6	35424067	35424067	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:35424067C>T	ENST00000229769.2	+	2	977	c.792C>T	c.(790-792)gaC>gaT	p.D264D		NM_021922.2	NP_068741.1	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	264	Interaction with FANCC.				DNA repair	nucleoplasm	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)|skin(2)	13						CTGGCGAGGACGGTTCGAATC	0.498000			"""N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				94	222					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93106930	93106930	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:93106930G>A	ENST00000359558.2	-	6	609	c.310C>T	c.(310-312)Ccg>Tcg	p.P104S	CALCR_ENST00000421592.1_Missense_Mutation_p.P86S|CALCR_ENST00000426151.1_Missense_Mutation_p.P86S|CALCR_ENST00000394441.1_Missense_Mutation_p.P86S|CALCR_ENST00000360249.4_Missense_Mutation_p.P86S	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	86					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	ACTCCAGCCGGTGTGTCATCC	0.418000													25	32					0	0	1	0	0
PRNP	5621	broad.mit.edu	37	20	4680506	4680506	+	Missense_Mutation	SNP	T	T	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:4680506T>G	ENST00000379440.4	+	2	927	c.640T>G	c.(640-642)Tgt>Ggt	p.C214G	PRNP_ENST00000430350.2_Missense_Mutation_p.C214G	NM_000311.3|NM_001080121.1|NM_001080122.1|NM_001080123.1|NM_001271561.1|NM_183079.2	NP_000302.1|NP_001073590.1|NP_001073591.1|NP_001073592.1|NP_001258490.1|NP_898902.1	P04156	PRIO_HUMAN	prion protein	214	Interaction with GRB2, ERI3 and SYN1 (By similarity).				axon guidance|cell cycle arrest|cellular copper ion homeostasis|metabolic process|negative regulation of activated T cell proliferation|negative regulation of calcineurin-NFAT signaling pathway|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-2 production|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell receptor signaling pathway|protein homooligomerization|response to oxidative stress	anchored to membrane|endoplasmic reticulum|extrinsic to membrane|Golgi apparatus|membrane raft|nucleus|plasma membrane	copper ion binding|identical protein binding|microtubule binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	14					Tetracycline(DB00759)	TGAGCAGATGTGTATCACCCA	0.522000													67	36					0	0	1	0	0
DHX34	9704	broad.mit.edu	37	19	47856557	47856557	+	Silent	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:47856557C>A	ENST00000328771.4	+	2	619	c.270C>A	c.(268-270)atC>atA	p.I90I		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	90						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		AGCACAGCATCCCAGCGCTGG	0.587000													54	105					6.176e-18	6.71171e-18	1	1	0
HECTD4	283450	broad.mit.edu	37	12	112621993	112621993	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:112621993C>T	ENST00000550722.1	-	61	10734	c.10339G>A	c.(10339-10341)Gag>Aag	p.E3447K	HECTD4_ENST00000430131.2_Missense_Mutation_p.E3171K|HECTD4_ENST00000377560.5_Missense_Mutation_p.E3421K	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		GCTGTTACCTCCACGACTGCG	0.527000													121	165					0	0	1	0	0
WDR62	284403	broad.mit.edu	37	19	36574054	36574054	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:36574054A>G	ENST00000401500.2	+	11	1496	c.1461A>G	c.(1459-1461)acA>acG	p.T487T	WDR62_ENST00000270301.7_Silent_p.T487T	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	487					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			AGAATGGGACACCCATGGACG	0.602000													4	14					0	0	1	0	0
IFNW1	3467	broad.mit.edu	37	9	21141286	21141286	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:21141286C>T	ENST00000380229.2	-	1	858	c.284G>A	c.(283-285)cGc>cAc	p.R95H		NM_002177.1	NP_002168.1	P05000	IFNW1_HUMAN	interferon, omega 1	95			R -> S (in dbSNP:rs2230055).		cell cycle arrest|defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|kidney(1)|lung(2)|ovary(1)	5				GBM - Glioblastoma multiforme(5;2.35e-185)|Lung(24;2.24e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AGCAGAGGAGCGCTCTGTGTG	0.557000													42	64					0	0	1	0	0
GNB1L	0	broad.mit.edu	37	22	19776481	19776481	+	Silent	SNP	C	C	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:19776481C>G	ENST00000329517.6	-	8	971	c.735G>C	c.(733-735)gtG>gtC	p.V245V	GNB1L_ENST00000460402.1_5'UTR|GNB1L_ENST00000405009.1_Intron|GNB1L_ENST00000403325.1_Silent_p.V245V	NM_053004.2	NP_443730.1	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 1-like	245					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	12	Colorectal(54;0.0993)					GAGTCCCACGCACCTGTGAGA	0.642000													26	58					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113729502	113729502	+	Splice_Site	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:113729502C>T	ENST00000397030.1	+	11	1443	c.1407_splice	c.e11+1	p.T469_splice	MCF2L_ENST00000434480.2_Splice_Site_p.T442_splice|MCF2L_ENST00000442652.2_Splice_Site_p.T466_splice|MCF2L_ENST00000375597.4_Splice_Site_p.T434_splice|MCF2L_ENST00000421756.1_Splice_Site_p.T440_splice|MCF2L_ENST00000375608.3_Splice_Site_p.T466_splice|MCF2L_ENST00000375604.2_Splice_Site_p.T493_splice|MCF2L_ENST00000535094.2_Splice_Site_p.T436_splice|MCF2L_ENST00000375601.3_Splice_Site_p.T440_splice|MCF2L_ENST00000423482.2_Splice_Site_p.T434_splice			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	466					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CGCCTGGAGACGGTAGGCCGA	0.687000													11	14					0	0	1	0	0
NTN3	4917	broad.mit.edu	37	16	2522735	2522735	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:2522735G>A	ENST00000293973.1	+	2	1165	c.962G>A	c.(961-963)cGc>cAc	p.R321H		NM_006181.2	NP_006172.1	O00634	NET3_HUMAN	netrin 3	321	Laminin EGF-like 2.				axon guidance|muscle cell differentiation|positive regulation of muscle cell differentiation	proteinaceous extracellular matrix				breast(1)|central_nervous_system(2)|lung(3)|prostate(1)	7						CGCCGCTGCCGCTTCAACATG	0.692000													61	85					0	0	1	0	0
AKR1B15	441282	broad.mit.edu	37	7	134252969	134252969	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:134252969C>T	ENST00000457545.2	+	4	470	c.210C>T	c.(208-210)caC>caT	p.H70H	AKR1B15_ENST00000423958.1_Silent_p.H42H	NM_001080538.2	NP_001074007.2	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	70							oxidoreductase activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|urinary_tract(1)	18						AATATCGCCACATTGACTGTG	0.453000													40	52					0	0	1	0	0
AHDC1	27245	broad.mit.edu	37	1	27877512	27877512	+	Missense_Mutation	SNP	C	C	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:27877512C>G	ENST00000374011.2	-	6	2083	c.1115G>C	c.(1114-1116)gGc>gCc	p.G372A	AHDC1_ENST00000482400.2_5'UTR|AHDC1_ENST00000247087.5_Missense_Mutation_p.G372A	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	372	Pro-rich.						DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		CCCGGGGGGGCCGTGCGGTGA	0.697000													11	15					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10078753	10078753	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:10078753A>G	ENST00000264828.3	-	60	4402	c.4317T>C	c.(4315-4317)ggT>ggC	p.G1439G		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1439	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GACCAGGGGGACCCTAGGAAA	0.582000													37	52					0	0	1	0	0
ZNF408	79797	broad.mit.edu	37	11	46724534	46724534	+	Splice_Site	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:46724534C>T	ENST00000311764.2	+	4	623	c.392_splice	c.e4-1	p.S131_splice		NM_001184751.1|NM_024741.2	NP_001171680.1|NP_079017.1	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TGCTTTGCAGCTTGGTACAAC	0.577000													30	39					0	0	1	0	0
TOB2	10766	broad.mit.edu	37	22	41833282	41833282	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:41833282C>T	ENST00000327492.3	-	2	774	c.68G>A	c.(67-69)cGc>cAc	p.R23H		NM_016272.3	NP_057356.1	Q14106	TOB2_HUMAN	transducer of ERBB2, 2	23					female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10						GTCTGCCCGGCGCCGGGGCAG	0.542000													39	38					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128471558	128471558	+	Silent	SNP	C	C	T	rs151283651		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:128471558C>T	ENST00000322313.4	-	18	3065	c.2907G>A	c.(2905-2907)ccG>ccA	p.P969P		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	969					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TCTCTGACATCGGGCCCATGT	0.612000													14	39					0	0	1	0	0
SSX5	6758	broad.mit.edu	37	X	48047159	48047159	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:48047159T>C	ENST00000311798.1	-	8	650	c.598A>G	c.(598-600)Agg>Ggg	p.R200G	SSX5_ENST00000347757.1_Missense_Mutation_p.R159G|SSX5_ENST00000376923.1_Missense_Mutation_p.R159G	NM_021015.3	NP_066295.3	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|skin(1)	18						TGTTTCCCCCTTTTGGGTCCT	0.478000													129	202					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20335435	20335435	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:20335435C>T	ENST00000302555.5	-	3	387	c.238G>A	c.(238-240)Gca>Aca	p.A80T	GP2_ENST00000381360.5_Intron|GP2_ENST00000341642.5_Intron|GP2_ENST00000381362.4_Missense_Mutation_p.A80T			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	80						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						TGGGACCCTGCTGAGTTCTCT	0.572000													37	45					0	0	1	0	0
GLP2R	9340	broad.mit.edu	37	17	9763352	9763352	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:9763352A>G	ENST00000262441.5	+	7	1372	c.859A>G	c.(859-861)Acg>Gcg	p.T287A	GLP2R_ENST00000574745.1_Missense_Mutation_p.T107A	NM_004246.1	NP_004237.1	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor	287					G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				endometrium(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	44					Glucagon recombinant(DB00040)	CTACCTCCACACGCTGCTGGA	0.572000													11	25					0	0	1	0	0
PDE4D	5144	broad.mit.edu	37	5	58476445	58476445	+	Missense_Mutation	SNP	A	A	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:58476445A>T	ENST00000340635.6	-	5	959	c.784T>A	c.(784-786)Tcc>Acc	p.S262T	PDE4D_ENST00000546160.1_Missense_Mutation_p.S201T|PDE4D_ENST00000507116.1_Missense_Mutation_p.S198T|PDE4D_ENST00000405755.2_Missense_Mutation_p.S140T|PDE4D_ENST00000360047.5_Missense_Mutation_p.S126T|PDE4D_ENST00000502575.1_Missense_Mutation_p.S198T|PDE4D_ENST00000503947.1_5'UTR|PDE4D_ENST00000503258.1_Missense_Mutation_p.S132T|PDE4D_ENST00000502484.2_Missense_Mutation_p.S201T	NM_001104631.1	NP_001098101.1	Q08499	PDE4D_HUMAN	phosphodiesterase 4D, cAMP-specific	262					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|pancreas(1)	15		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	TTGTTGATGGATGGTTGGTTG	0.398000													11	19					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63525089	63525089	+	Missense_Mutation	SNP	T	T	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:63525089T>G	ENST00000536984.2	+	8	1967	c.1273T>G	c.(1273-1275)Ttc>Gtc	p.F425V	CDH7_ENST00000397968.2_Missense_Mutation_p.F425V|CDH7_ENST00000323011.3_Missense_Mutation_p.F425V			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	425	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				GGAGAGATACTTCAATATTGA	0.388000													5	109					0	0	1	0	0
SCRN3	79634	broad.mit.edu	37	2	175292598	175292598	+	Missense_Mutation	SNP	A	A	G	rs76634317		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:175292598A>G	ENST00000272732.6	+	8	1332	c.1250A>G	c.(1249-1251)aAt>aGt	p.N417S	SCRN3_ENST00000409673.3_Missense_Mutation_p.N410S|SCRN3_ENST00000548921.1_3'UTR	NM_001193528.1|NM_024583.4	NP_001180457.1|NP_078859.2	Q0VDG4	SCRN3_HUMAN	secernin 3	417					proteolysis		dipeptidase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|urinary_tract(3)	13			OV - Ovarian serous cystadenocarcinoma(117;0.229)			TATCAGTCAAATTTATCAGTC	0.323000													13	21					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24905856	24905856	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:24905856G>T	ENST00000405141.1	+	9	1102	c.391G>T	c.(391-393)Ggg>Tgg	p.G131W	NCOA1_ENST00000348332.3_Missense_Mutation_p.G131W|NCOA1_ENST00000407230.1_5'UTR|NCOA1_ENST00000406961.1_Missense_Mutation_p.G131W|NCOA1_ENST00000288599.5_Missense_Mutation_p.G131W|NCOA1_ENST00000538539.1_Missense_Mutation_p.G131W|NCOA1_ENST00000395856.3_Missense_Mutation_p.G131W			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	131	PAS.							p.G131W(1)	PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAACTGTGAAGGGAGAATTGT	0.368000			T	PAX3	alveolar rhadomyosarcoma								18	41					2.37509e-13	2.54019e-13	1	1	0
FGFR2	2263	broad.mit.edu	37	10	123325123	123325123	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:123325123C>T	ENST00000358487.5	-	3	477	c.205G>A	c.(205-207)Gtg>Atg	p.V69M	FGFR2_ENST00000369056.1_Missense_Mutation_p.V69M|FGFR2_ENST00000369061.4_Missense_Mutation_p.V69M|FGFR2_ENST00000369059.1_Intron|FGFR2_ENST00000457416.2_Missense_Mutation_p.V69M|FGFR2_ENST00000490349.1_5'UTR|FGFR2_ENST00000359354.2_Missense_Mutation_p.V69M|FGFR2_ENST00000356226.4_Intron|FGFR2_ENST00000360144.3_Intron|FGFR2_ENST00000351936.6_Missense_Mutation_p.V69M|FGFR2_ENST00000346997.2_Missense_Mutation_p.V69M|FGFR2_ENST00000357555.5_Intron|FGFR2_ENST00000369060.4_Missense_Mutation_p.V69M	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	69	Ig-like C2-type 1.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CAACTGATCACGGCGGCATCT	0.552000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				81	157					0	0	1	0	0
RPS6KL1	83694	broad.mit.edu	37	14	75388084	75388084	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:75388084G>A	ENST00000555647.1	-	3	448	c.161C>T	c.(160-162)gCc>gTc	p.A54V	RPS6KL1_ENST00000557413.1_Missense_Mutation_p.A54V|RPS6KL1_ENST00000554900.1_Intron|RPS6KL1_ENST00000354625.2_Missense_Mutation_p.A54V|RPS6KL1_ENST00000358328.4_Missense_Mutation_p.A54V			Q9Y6S9	RPKL1_HUMAN	ribosomal protein S6 kinase-like 1	54						ribosome	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(234;0.00658)		GATCTGCGTGGCCGCATCCAC	0.592000													36	65					0	0	1	0	0
SEMG1	6406	broad.mit.edu	37	20	43837242	43837242	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:43837242A>G	ENST00000372781.3	+	2	1361	c.1304A>G	c.(1303-1305)gAt>gGt	p.D435G	SEMG1_ENST00000244069.6_Missense_Mutation_p.D375G	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				GGGGGATTGGATATTGTAATT	0.403000													121	90					0	0	1	0	0
MYO6	4646	broad.mit.edu	37	6	76624710	76624710	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:76624710T>C	ENST00000369981.3	+	35	4121	c.3842T>C	c.(3841-3843)cTg>cCg	p.L1281P	MYO6_ENST00000369985.4_Missense_Mutation_p.L1257P|MYO6_ENST00000369975.1_Missense_Mutation_p.L1248P|MYO6_ENST00000369977.3_Missense_Mutation_p.L1280P			Q9UM54	MYO6_HUMAN	myosin VI	1289					actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		ACAGCCATGCTGCAGAGTCTG	0.512000													22	13					0	0	1	0	0
RHBDF2	79651	broad.mit.edu	37	17	74469406	74469406	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:74469406A>G	ENST00000591885.1	-	16	2287	c.1737T>C	c.(1735-1737)tgT>tgC	p.C579C	RHBDF2_ENST00000389760.4_Silent_p.C579C|RHBDF2_ENST00000313080.4_Silent_p.C608C			Q6PJF5	RHDF2_HUMAN	rhomboid 5 homolog 2 (Drosophila)	608					negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(4)|skin(1)	27						TGGTGATCTCACAGCTAAGGG	0.597000													17	13					0	0	1	0	0
DYRK1B	9149	broad.mit.edu	37	19	40316673	40316673	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:40316673C>T	ENST00000593685.1	-	11	2040	c.1572G>A	c.(1570-1572)aaG>aaA	p.K524K	DYRK1B_ENST00000430012.2_Silent_p.K484K|DYRK1B_ENST00000597639.1_Silent_p.K496K|DYRK1B_ENST00000348817.3_Silent_p.K496K|DYRK1B_ENST00000323039.5_Silent_p.K524K			Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	524					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(7)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	24	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			CTTGATGTGTCTTGTGGGGCA	0.642000													29	51					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	59					0	0	1	0	0
RXFP3	51289	broad.mit.edu	37	5	33937225	33937225	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:33937225C>T	ENST00000330120.3	+	1	735	c.380C>T	c.(379-381)aCg>aTg	p.T127M		NM_016568.3	NP_057652.1	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	127						integral to plasma membrane	N-formyl peptide receptor activity			endometrium(4)|large_intestine(9)|lung(24)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)	42						CTGGCGCTGACGGACTTTCAG	0.572000													54	89					0	0	1	0	0
MTERFD2	130916	broad.mit.edu	37	2	242036781	242036781	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:242036781A>G	ENST00000391980.2	-	3	640	c.582T>C	c.(580-582)atT>atC	p.I194I	MTERFD2_ENST00000407095.3_Silent_p.I194I|MTERFD2_ENST00000495694.1_Intron|MTERFD2_ENST00000406593.1_Silent_p.I6I	NM_182501.3	NP_872307.2	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	194										endometrium(3)|large_intestine(6)|lung(5)|ovary(1)|skin(2)|urinary_tract(3)	20		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		CAGTGTCGTTAATGTCCTGCT	0.463000													23	26					0	0	1	0	0
PNMA2	10687	broad.mit.edu	37	8	26365217	26365217	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:26365217C>T	ENST00000522362.2	-	3	1949	c.1055G>A	c.(1054-1056)cGa>cAa	p.R352Q		NM_007257.5	NP_009188.1	Q9UL42	PNMA2_HUMAN	paraneoplastic Ma antigen 2	352					apoptosis	nucleolus	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)	11		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		ATAGCCATCTCGTTCCTCTGG	0.522000													55	212					0	0	1	0	0
DOLK	22845	broad.mit.edu	37	9	131709514	131709514	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:131709514C>A	ENST00000372586.3	-	1	384	c.69G>T	c.(67-69)gaG>gaT	p.E23D	RP11-101E3.5_ENST00000482796.1_Intron	NM_014908.3	NP_055723.1	Q9UPQ8	DOLK_HUMAN	dolichol kinase	23					dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity			breast(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	11						CTACTGCCGCCTCTGCCAGCA	0.662000													52	50					4.33383e-22	4.80502e-22	1	1	0
FAM66D	0	broad.mit.edu	37	8	11985834	11985834	+	RNA	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:11985834G>A	ENST00000434078.2	+	0	608					NR_027425.1																						ACCCGGTGACGACGAGAACAG	0.483000													6	51					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79058095	79058095	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:79058095G>A	ENST00000388820.4	-	19	4368	c.4158C>T	c.(4156-4158)caC>caT	p.H1386H		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1386					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CAGGGACTCTGTGGCTGTTGG	0.682000													42	61					0	0	1	0	0
KHSRP	8570	broad.mit.edu	37	19	6417016	6417016	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:6417016G>A	ENST00000398148.3	-	12	1256	c.1164C>T	c.(1162-1164)gaC>gaT	p.D388D		NM_003685.2	NP_003676.2	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	388	Gly-rich.				mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|liver(1)|lung(6)|skin(1)|soft_tissue(1)	17						TCTGGAGGAGGTCGTTGATGA	0.642000													9	103					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69472531	69472531	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:69472531C>T	ENST00000303714.4	+	18	1931	c.1609C>T	c.(1609-1611)Cct>Tct	p.P537S		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	537	Pro-rich.				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						cccgtccccaccttccaccct	0.706000									Familial Infantile Hemangioma				3	6					0	0	1	0	0
IGKV4-1	0	broad.mit.edu	37	2	89185510	89185510	+	RNA	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:89185510G>A	ENST00000390243.2	+	0	379																											AACCAGGACAGCCTCCTAAGC	0.532000													28	30					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28387443	28387443	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:28387443A>G	ENST00000261609.7	-	76	11749	c.11641T>C	c.(11641-11643)Tcc>Ccc	p.S3881P		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	3881					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCAACACGGGAGGCCATGCAG	0.527000													19	28					0	0	1	0	0
HCLS1	3059	broad.mit.edu	37	3	121351302	121351302	+	Missense_Mutation	SNP	C	C	T	rs149387044		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:121351302C>T	ENST00000314583.3	-	12	1208	c.1117G>A	c.(1117-1119)Gag>Aag	p.E373K	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Missense_Mutation_p.E336K	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	373					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		TTctcaggctcgggctcaggc	0.607000													102	144					0	0	1	0	0
CETN2	1069	broad.mit.edu	37	X	151997817	151997817	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:151997817G>A	ENST00000370277.3	-	3	233	c.167C>T	c.(166-168)gCa>gTa	p.A56V	CETN2_ENST00000493482.1_5'UTR	NM_004344.1	NP_004335.1	P41208	CETN2_HUMAN	centrin, EF-hand protein, 2	56	EF-hand 1.				cell division|centriole replication|G2/M transition of mitotic cell cycle|mitosis|nucleotide-excision repair|regulation of cytokinesis	centriole|cytosol|XPC complex	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(1)|lung(4)|prostate(1)|skin(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					GGCCCTCATTGCCACCTATAA	0.393000								Direct reversal of damage;Nucleotide excision repair (NER)					15	41					0	0	1	0	0
FZD3	7976	broad.mit.edu	37	8	28384902	28384902	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:28384902A>G	ENST00000240093.3	+	5	1103	c.625A>G	c.(625-627)Att>Gtt	p.I209V	FZD3_ENST00000537916.1_Missense_Mutation_p.I209V	NM_017412.3	NP_059108.1	Q9NPG1	FZD3_HUMAN	frizzled family receptor 3	209					canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(15)|ovary(1)|prostate(1)|skin(1)	41		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		CATAGGATTGATTTCAATCAT	0.363000													34	155					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13399755	13399755	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:13399755C>T	ENST00000254508.5	-	16	2377	c.2295G>A	c.(2293-2295)atG>atA	p.M765I		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	765					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					GCGGACAGGACATGTCCAGCT	0.657000													30	99					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152281526	152281526	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:152281526C>T	ENST00000368799.1	-	3	5871	c.5836G>A	c.(5836-5838)Gct>Act	p.A1946T	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1946	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTCCCAAGCAGATCCAAGA	0.567000									Ichthyosis				173	304					0	0	1	0	0
SLC39A9	55334	broad.mit.edu	37	14	69925096	69925096	+	Missense_Mutation	SNP	T	T	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:69925096T>A	ENST00000031146.4	+	6	1190	c.512T>A	c.(511-513)cTt>cAt	p.L171H	SLC39A9_ENST00000556605.1_Intron|SLC39A9_ENST00000336643.5_Missense_Mutation_p.L237H|SLC39A9_ENST00000555245.1_3'UTR|SLC39A9_ENST00000557046.1_Missense_Mutation_p.L214H			Q9NUM3	S39A9_HUMAN	solute carrier family 39, member 9	237					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|skin(1)|stomach(1)	14				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		AAAGAAGCCCTTTCAGAGGTG	0.468000													90	87					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79552204	79552204	+	Silent	SNP	C	C	T	rs148200124		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:79552204C>T	ENST00000372391.2	-	32	5759	c.5754G>A	c.(5752-5754)ccG>ccA	p.P1918P	RP13-39P12.3_ENST00000434097.2_RNA|DLG5_ENST00000372388.2_Silent_p.P1578P	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1918					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TCTCCTAGAGCGGGCAGGCTG	0.532000													69	148					0	0	1	0	0
OR2A14	135941	broad.mit.edu	37	7	143826815	143826815	+	Missense_Mutation	SNP	T	T	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:143826815T>A	ENST00000408899.2	+	1	665	c.610T>A	c.(610-612)Ttc>Atc	p.F204I		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					AGCCTGCGTGTTCATCCTGGT	0.567000													121	139					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75182877	75182877	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:75182877C>T	ENST00000336926.6	-	22	2196	c.2170G>A	c.(2170-2172)Gcc>Acc	p.A724T	HIP1_ENST00000434438.2_Missense_Mutation_p.A724T	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	724					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						TGCTTACAGGCCTCGGTCAGT	0.562000			T	PDGFRB	CMML								23	38					0	0	1	0	0
DAB2	1601	broad.mit.edu	37	5	39383336	39383336	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:39383336T>C	ENST00000320816.6	-	10	1192	c.725A>G	c.(724-726)gAa>gGa	p.E242G	DAB2_ENST00000339788.6_Intron|DAB2_ENST00000545653.1_Missense_Mutation_p.E221G|DAB2_ENST00000509337.1_Missense_Mutation_p.E221G	NM_001343.3	NP_001334.2	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	242					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			GGTGTCGATTTCAGAGTTTAG	0.383000													49	70					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186953726	186953726	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:186953726C>T	ENST00000296280.6	-	11	2158	c.1933G>A	c.(1933-1935)Gag>Aag	p.E645K	MASP1_ENST00000337774.5_Intron|MASP1_ENST00000495249.1_5'UTR|MASP1_ENST00000392472.2_Missense_Mutation_p.E532K	NM_139125.3	NP_624302.1	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	627	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		AACATGTTCTCCGTGACGCTG	0.547000													23	34					0	0	1	0	0
GPRC5A	0	broad.mit.edu	37	12	13061187	13061187	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:13061187G>A	ENST00000014914.5	+	2	894	c.4G>A	c.(4-6)Gct>Act	p.A2T	GPRC5A_ENST00000542056.1_Intron	NM_003979.3	NP_003970.1	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5, member A	2						cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	18		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	GTCCAGAATGGCTACAACAGT	0.473000													23	25					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149509511	149509511	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:149509511G>A	ENST00000261799.4	-	10	1857	c.1388C>T	c.(1387-1389)cCc>cTc	p.P463L		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	463	Ig-like C2-type 5.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CAGCAGCGTGGGCGGCAGCTC	0.612000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""						OREG0016927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	56	90					0	0	1	0	0
SEC24B	10427	broad.mit.edu	37	4	110384778	110384778	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:110384778G>A	ENST00000265175.5	+	2	910	c.855G>A	c.(853-855)gcG>gcA	p.A285A	SEC24B_ENST00000399100.2_Silent_p.A285A|SEC24B_ENST00000504968.2_Silent_p.A316A	NM_006323.2	NP_006314.2	O95487	SC24B_HUMAN	SEC24 family member B	285					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TGGCTGTAGCGAACAACAACC	0.413000													30	57					0	0	1	0	0
PRADC1	84279	broad.mit.edu	37	2	73455661	73455661	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:73455661C>A	ENST00000258083.2	-	5	555	c.488G>T	c.(487-489)tGg>tTg	p.W163L	PRADC1_ENST00000480093.1_5'UTR	NM_032319.1	NP_115695.1	Q9BSG0	PADC1_HUMAN	protease-associated domain containing 1	163	PA.					extracellular region				endometrium(1)|large_intestine(1)|lung(2)	4						AATGATGGCCCATGGCAGCCC	0.562000													20	30					1.28384e-07	1.3388e-07	1	1	0
DMRTC2	63946	broad.mit.edu	37	19	42351810	42351810	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:42351810C>T	ENST00000269945.3	+	3	282	c.231C>T	c.(229-231)cgC>cgT	p.R77R	DMRTC2_ENST00000602098.1_3'UTR|DMRTC2_ENST00000596827.1_Silent_p.R77R	NM_001040283.1	NP_001035373.1	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	77					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	10						TTAGGGAGCGCCGCAGGGTCA	0.602000													13	26					0	0	1	0	0
KLHL31	401265	broad.mit.edu	37	6	53517031	53517031	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:53517031C>T	ENST00000370905.3	-	3	1410	c.1270G>A	c.(1270-1272)Gcg>Acg	p.A424T	KLHL31_ENST00000407079.1_Missense_Mutation_p.A424T	NM_001003760.4	NP_001003760.2	Q9H511	KLH31_HUMAN	kelch-like family member 31	424					regulation of transcription, DNA-dependent|transcription, DNA-dependent					autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					CGGCCGCCCGCGGCGTACACG	0.647000													41	109					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94650983	94650983	+	Missense_Mutation	SNP	G	G	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:94650983G>C	ENST00000260526.6	-	17	2017	c.1835C>G	c.(1834-1836)aCa>aGa	p.T612R	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	612					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity	p.T612I(1)		NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		AAACTTGTGTGTGAGAGCTGC	0.373000													24	37					0	0	1	0	0
CATSPER4	378807	broad.mit.edu	37	1	26527326	26527326	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:26527326C>T	ENST00000456354.2	+	8	1060	c.993C>T	c.(991-993)ggC>ggT	p.G331G		NM_198137.1	NP_937770.1	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	331					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		CCCAGACAGGCGCAGAGGAAG	0.627000													25	51					0	0	1	0	0
MBOAT7	79143	broad.mit.edu	37	19	54684567	54684567	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:54684567G>A	ENST00000245615.1	-	6	1257	c.777C>T	c.(775-777)gcC>gcT	p.A259A	MBOAT7_ENST00000338624.6_Silent_p.A186A|MBOAT7_ENST00000391754.1_Silent_p.A259A|MBOAT7_ENST00000431666.2_Silent_p.A186A	NM_024298.3	NP_077274.3	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	259					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCCCAAAGCCGGCGGCAATGC	0.711000											OREG0003644	type=REGULATORY REGION|Gene=AK123290|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	6	8					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136566315	136566315	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:136566315G>A	ENST00000264162.2	-	8	3612	c.3602C>T	c.(3601-3603)gCc>gTc	p.A1201V		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1201	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAAGACGTCGGCCGTCGCCCT	0.557000													96	115					0	0	1	0	0
TRIM3	10612	broad.mit.edu	37	11	6478961	6478961	+	Silent	SNP	C	C	T	rs116462813	by1000genomes	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:6478961C>T	ENST00000525074.1	-	4	874	c.480G>A	c.(478-480)gcG>gcA	p.A160A	TRIM3_ENST00000536344.1_Silent_p.A41A|TRIM3_ENST00000537602.1_Silent_p.A160A|TRIM3_ENST00000529058.1_5'UTR|TRIM3_ENST00000345851.3_Silent_p.A160A|TRIM3_ENST00000359518.3_Silent_p.A160A	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	160					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTGCAGGGCCGCCTTGTGCT	0.687000													39	61					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55497518	55497518	+	Splice_Site	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:55497518G>T	ENST00000543010.1	+	8	2344		c.e8-1		NLRP2_ENST00000537859.1_Splice_Site|NLRP2_ENST00000427260.2_Splice_Site|NLRP2_ENST00000339757.7_Splice_Site|NLRP2_ENST00000391721.4_Splice_Site|NLRP2_ENST00000538819.1_Splice_Site|NLRP2_ENST00000263437.6_Splice_Site|NLRP2_ENST00000448584.2_Splice_Site	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2						apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CTTTTCCCTAGGTTCAAAAAC	0.423000													15	27					1.05317e-09	1.1155e-09	1	1	0
CHODL	140578	broad.mit.edu	37	21	19629084	19629084	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr21:19629084G>A	ENST00000299295.2	+	2	729	c.338G>A	c.(337-339)gGt>gAt	p.G113D	CHODL_ENST00000400127.1_Missense_Mutation_p.G72D|CHODL_ENST00000400131.1_Missense_Mutation_p.G72D|CHODL_ENST00000400135.1_Missense_Mutation_p.G72D|CHODL_ENST00000543733.1_Missense_Mutation_p.G94D|CHODL_ENST00000338326.3_Missense_Mutation_p.G72D|CHODL_ENST00000400128.1_Missense_Mutation_p.G72D	NM_001204175.1|NM_024944.2	NP_001191104.1|NP_079220.2	Q9H9P2	CHODL_HUMAN	chondrolectin	113	C-type lectin.				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			kidney(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		CAAACATCTGGTGCCTGCCCA	0.507000													45	61					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112786408	112786408	+	Silent	SNP	C	C	T	rs140956730		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:112786408C>T	ENST00000295408.4	+	19	3224	c.2967C>T	c.(2965-2967)gaC>gaT	p.D989D	MERTK_ENST00000409780.1_Silent_p.D813D|MERTK_ENST00000421804.2_Silent_p.D989D			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	989					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						TGTTTGCTGACGACTCCTCAG	0.502000													25	29					0	0	1	0	0
MGAT5	4249	broad.mit.edu	37	2	135119889	135119889	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:135119889G>A	ENST00000409645.1	+	11	1542	c.1290G>A	c.(1288-1290)caG>caA	p.Q430Q	MGAT5_ENST00000281923.2_Silent_p.Q430Q			Q09328	MGT5A_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	430					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|pancreas(1)|skin(3)	36				BRCA - Breast invasive adenocarcinoma(221;0.0964)		TGGTTGAGCAGCACCTGAACT	0.458000													86	119					0	0	1	0	0
SPATA13	221178	broad.mit.edu	37	13	24860369	24860369	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:24860369C>T	ENST00000424834.2	+	8	2792	c.2319C>T	c.(2317-2319)aaC>aaT	p.N773N	SPATA13_ENST00000382095.4_Silent_p.N148N|SPATA13_ENST00000409126.1_Silent_p.N70N|SPATA13_ENST00000399949.2_Silent_p.N70N|SPATA13_ENST00000382108.3_Silent_p.N773N|SPATA13_ENST00000343003.6_Silent_p.N92N			Q96N96	SPT13_HUMAN	spermatogenesis associated 13	148					cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			breast(4)|endometrium(2)|large_intestine(9)|lung(4)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		GTGATGGCAACGTGGTCTGCG	0.587000													57	81					0	0	1	0	0
POMT1	10585	broad.mit.edu	37	9	134381807	134381807	+	Translation_Start_Site	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:134381807G>A	ENST00000404875.2	+	0	190				POMT1_ENST00000419118.2_De_novo_Start_OutOfFrame|POMT1_ENST00000402686.3_Missense_Mutation_p.D83N|POMT1_ENST00000372228.3_Missense_Mutation_p.D83N|POMT1_ENST00000354713.4_Missense_Mutation_p.R47Q|POMT1_ENST00000341012.7_Missense_Mutation_p.D29N|POMT1_ENST00000541219.1_De_novo_Start_InFrame|POMT1_ENST00000423007.1_Missense_Mutation_p.D83N	NM_001136114.1	NP_001129586.1	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1						multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	31		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		AGGAGGATTCGATGGCAATTT	0.348000													83	122					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	99145154	99145154	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:99145154G>A	ENST00000547776.2	-	25	3650	c.3651C>T	c.(3649-3651)cgC>cgT	p.R1217R	ANKS1B_ENST00000550693.2_Silent_p.R407R|ANKS1B_ENST00000549493.2_Silent_p.R467R|ANKS1B_ENST00000547446.1_Silent_p.R352R|ANKS1B_ENST00000549025.2_Silent_p.R315R|ANKS1B_ENST00000341752.7_Silent_p.R223R|ANKS1B_ENST00000549558.2_Silent_p.R383R|ANKS1B_ENST00000329257.7_Silent_p.R1217R|ANKS1B_ENST00000547010.1_Silent_p.R733R|ANKS1B_ENST00000333732.7_Silent_p.R247R|ANKS1B_ENST00000546568.1_Silent_p.R383R|ANKS1B_ENST00000546960.1_Silent_p.R443R|ANKS1B_ENST00000332712.7_Silent_p.R407R	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	1217						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GAATGCTAACGCGGGGCTTGG	0.498000													18	32					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215853543	215853543	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:215853543C>T	ENST00000366943.2	-	62	12628	c.12242G>A	c.(12241-12243)cGg>cAg	p.R4081Q	USH2A_ENST00000307340.3_Missense_Mutation_p.R4081Q			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4081	Fibronectin type-III 26.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TAGCAATGCCCGGCCATTCTC	0.408000										HNSCC(13;0.011)			47	74					0	0	1	0	0
S1PR2	9294	broad.mit.edu	37	19	10335188	10335188	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:10335188C>T	ENST00000590320.1	-	2	504	c.394G>A	c.(394-396)Gtg>Atg	p.V132M		NM_004230.3	NP_004221.3	O95136	S1PR2_HUMAN	sphingosine-1-phosphate receptor 2	132					activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						GCAATGGCCACGTGGCGCTCA	0.637000													29	43					0	0	1	0	0
PRKAR2A	5576	broad.mit.edu	37	3	48802450	48802450	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:48802450C>T	ENST00000265563.8	-	8	1109	c.860G>A	c.(859-861)cGc>cAc	p.R287H	PRKAR2A_ENST00000296446.8_Missense_Mutation_p.R287H|PRKAR2A_ENST00000454963.1_Missense_Mutation_p.R287H	NM_004157.2	NP_004148.1	P13861	KAP2_HUMAN	protein kinase, cAMP-dependent, regulatory, type II, alpha	287					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|membrane fraction	cAMP binding|cAMP-dependent protein kinase regulator activity		SLC26A6/PRKAR2A(2)	breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000176)|Kidney(197;0.00246)|KIRC - Kidney renal clear cell carcinoma(197;0.00261)		AGTGATTATGCGTTCTCCATC	0.408000													12	22					0	0	1	0	0
DHX57	90957	broad.mit.edu	37	2	39088332	39088332	+	Missense_Mutation	SNP	A	A	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:39088332A>T	ENST00000295373.6	-	5	1346	c.1220T>A	c.(1219-1221)gTc>gAc	p.V407D	DHX57_ENST00000479345.2_5'UTR	NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	407							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				AGAATATACGACAGGTTCCGA	0.403000													53	69					0	0	1	0	0
BMP1	649	broad.mit.edu	37	8	22035142	22035142	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:22035142T>C	ENST00000354870.5	+	6	1059	c.793T>C	c.(793-795)Tgt>Cgt	p.C265R	BMP1_ENST00000397816.3_Intron|BMP1_ENST00000306385.5_Intron|BMP1_ENST00000397814.3_Intron|BMP1_ENST00000306349.8_Intron			P13497	BMP1_HUMAN	bone morphogenetic protein 1	0	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		TTCCTTCCCATGTTCCCTTGA	0.612000													138	326					0	0	1	0	0
ZFP36L2	678	broad.mit.edu	37	2	43451501	43451501	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:43451501C>T	ENST00000282388.3	-	2	1735	c.1442G>A	c.(1441-1443)cGc>cAc	p.R481H	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	481					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				TGGCAGGCGGCGGCCAGGGTC	0.667000													7	9					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43627119	43627119	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:43627119G>A	ENST00000332857.6	-	4	1596	c.1568C>T	c.(1567-1569)gCa>gTa	p.A523V		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		ATTCTGCGATGCAGGGCAAGC	0.502000													150	208					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18364029	18364029	+	Missense_Mutation	SNP	A	A	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:18364029A>T	ENST00000429452.1	-	17	2634	c.2282T>A	c.(2281-2283)gTg>gAg	p.V761E	MICAL3_ENST00000383094.3_Intron|MICAL3_ENST00000444520.1_Intron|MICAL3_ENST00000585038.1_Missense_Mutation_p.V761E|MICAL3_ENST00000441493.2_Intron|MICAL3_ENST00000400561.2_Intron|MICAL3_ENST00000414725.2_Intron|MICAL3_ENST00000207726.7_Intron	NM_001136004.1	NP_001129476.1	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1248						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		CAGGGTGATCACTTTTTTGGG	0.542000													81	98					0	0	1	0	0
DSCC1	79075	broad.mit.edu	37	8	120850597	120850597	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:120850597C>T	ENST00000313655.4	-	8	1189	c.975G>A	c.(973-975)ctG>ctA	p.L325L		NM_024094.2	NP_076999.2	Q9BVC3	DCC1_HUMAN	DNA replication and sister chromatid cohesion 1	325					DNA replication|maintenance of mitotic sister chromatid cohesion|post-translational protein acetylation|regulation of DNA replication	chromatin|chromosome, centromeric region|nucleoplasm	DNA binding|protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|pancreas(1)	9	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CATCTACTTTCAGCAAAAATA	0.368000													45	150					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151123932	151123932	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:151123932C>T	ENST00000370325.1	-	8	1098	c.1045G>A	c.(1045-1047)Gtc>Atc	p.V349I	GABRE_ENST00000483564.1_5'UTR|GABRE_ENST00000370328.3_Missense_Mutation_p.V349I			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	349					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCAGAAGACGAAGCAGATG	0.488000													57	60					0	0	1	0	0
C7orf25	79020	broad.mit.edu	37	7	42949408	42949408	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:42949408C>T	ENST00000350427.4	-	2	1367	c.1092G>A	c.(1090-1092)acG>acA	p.T364T	C7orf25_ENST00000447342.1_Silent_p.T364T|C7orf25_ENST00000431882.2_Silent_p.T422T|C7orf25_ENST00000438029.1_Silent_p.T364T|PSMA2_ENST00000442788.1_3'UTR			Q9BPX7	CG025_HUMAN	chromosome 7 open reading frame 25	364										endometrium(6)|kidney(1)|large_intestine(7)|lung(2)|skin(1)	17						GGGTGTCTCCCGTCCCAAAAA	0.433000													41	37					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8448900	8448900	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:8448900C>T	ENST00000360416.3	-	13	1435	c.1297G>A	c.(1297-1299)Gca>Aca	p.A433T	MYH10_ENST00000379980.4_Missense_Mutation_p.A439T|MYH10_ENST00000396239.1_Missense_Mutation_p.A423T|MYH10_ENST00000269243.4_Missense_Mutation_p.A423T	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	423	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						TTTGCCAATGCTTCTACTGCA	0.398000													20	26					0	0	1	0	0
CLCC1	23155	broad.mit.edu	37	1	109493059	109493059	+	Translation_Start_Site	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:109493059T>C	ENST00000356970.2	-	2	108	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	CLCC1_ENST00000415331.1_Start_Codon_SNP_p.M1V|AKNAD1_ENST00000357393.4_Intron|CLCC1_ENST00000369970.3_Start_Codon_SNP_p.M1V|CLCC1_ENST00000369971.2_Splice_Site_p.M1_splice|CLCC1_ENST00000348264.2_Start_Codon_SNP_p.M1V|CLCC1_ENST00000302500.4_Start_Codon_SNP_p.M1V|CLCC1_ENST00000369976.1_Start_Codon_SNP_p.M1V|CLCC1_ENST00000369968.2_Start_Codon_SNP_p.M1V|CLCC1_ENST00000369969.2_Start_Codon_SNP_p.M1V			Q96S66	CLCC1_HUMAN	chloride channel CLIC-like 1	1						endoplasmic reticulum|Golgi apparatus|integral to membrane|nucleus				autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|liver(1)|skin(1)	14		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		GAACACAGCATCCTGTATAAG	0.299000													14	18					0	0	1	0	0
DTX3L	151636	broad.mit.edu	37	3	122289431	122289431	+	Missense_Mutation	SNP	G	G	A	rs142707005		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:122289431G>A	ENST00000296161.4	+	4	2254	c.2065G>A	c.(2065-2067)Gtg>Atg	p.V689M	DTX3L_ENST00000383661.3_Missense_Mutation_p.V177M	NM_138287.3	NP_612144.1	Q8TDB6	DTX3L_HUMAN	deltex 3-like (Drosophila)	689					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0459)		GATTTTTACAGTGGGGTACTC	0.433000													34	57					0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39883622	39883622	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:39883622C>T	ENST00000341184.6	+	2	485	c.270C>T	c.(268-270)gcC>gcT	p.A90A		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	90					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					GCAAGGCGGCCGAGGAGCTCC	0.701000													36	57					0	0	1	0	0
FAM214B	80256	broad.mit.edu	37	9	35105812	35105812	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:35105812C>T	ENST00000378561.1	-	7	4385	c.1330G>A	c.(1330-1332)Gtg>Atg	p.V444M	FAM214B_ENST00000488109.2_Missense_Mutation_p.V444M|FAM214B_ENST00000378566.1_Missense_Mutation_p.V139M|FAM214B_ENST00000603301.1_Missense_Mutation_p.V444M|FAM214B_ENST00000322813.5_Missense_Mutation_p.V444M|FAM214B_ENST00000605244.1_Missense_Mutation_p.V444M|FAM214B_ENST00000378557.1_Missense_Mutation_p.V444M|FAM214B_ENST00000378554.2_Intron			Q7L5A3	K1539_HUMAN	family with sequence similarity 214, member B	444						nucleus											TCAAAGGTCACAAGGAACATC	0.547000													24	42					0	0	1	0	0
GSR	2936	broad.mit.edu	37	8	30560725	30560725	+	Silent	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:30560725G>T	ENST00000221130.5	-	5	615	c.525C>A	c.(523-525)gcC>gcA	p.A175A	GSR_ENST00000546342.1_Silent_p.A175A|GSR_ENST00000541648.1_Silent_p.A175A|GSR_ENST00000537535.1_Silent_p.A175A|GSR_ENST00000414019.1_Silent_p.A132A	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	175					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	CACTCGTGAAGGCTGCATGGC	0.483000													13	198					4.3838e-07	4.56061e-07	1	1	0
C16orf59	80178	broad.mit.edu	37	16	2511156	2511156	+	Missense_Mutation	SNP	T	T	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:2511156T>G	ENST00000569496.1	+	4	595	c.536T>G	c.(535-537)cTc>cGc	p.L179R	C16orf59_ENST00000361837.4_Missense_Mutation_p.L179R|C16orf59_ENST00000563531.1_Missense_Mutation_p.L179R|C16orf59_ENST00000483320.1_Missense_Mutation_p.L12R			Q7L2K0	CP059_HUMAN	chromosome 16 open reading frame 59	179										lung(1)|skin(1)|urinary_tract(1)	3		Ovarian(90;0.17)				GGGGCGGGCCTCAGGGACCAG	0.677000													14	24					0	0	1	0	0
RAC3	5881	broad.mit.edu	37	17	79991680	79991680	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:79991680C>T	ENST00000306897.4	+	6	692	c.554C>T	c.(553-555)cCg>cTg	p.P185L		NM_005052.2	NP_005043.1	P60763	RAC3_HUMAN	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	185					actin cytoskeleton organization|cell projection assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endomembrane system|filamentous actin|growth cone|lamellipodium|neuronal cell body|plasma membrane	GTP binding|GTPase activity|protein binding			NS(1)|kidney(1)|skin(1)	3	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GTGAAGAAGCCGGGGAAGAAG	0.652000													17	7					0	0	1	0	0
TMEM176B	28959	broad.mit.edu	37	7	150490215	150490215	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:150490215C>T	ENST00000447204.2	-	5	933	c.561G>A	c.(559-561)tgG>tgA	p.W187*	TMEM176B_ENST00000492607.1_Nonsense_Mutation_p.W187*|TMEM176B_ENST00000434545.1_Nonsense_Mutation_p.W187*|TMEM176B_ENST00000429904.2_Nonsense_Mutation_p.W187*|TMEM176B_ENST00000326442.5_Nonsense_Mutation_p.W187*|TMEM176B_ENST00000450753.2_Nonsense_Mutation_p.W150*	NM_014020.3	NP_054739.3	Q3YBM2	T176B_HUMAN	transmembrane protein 176B	187					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				cervix(1)|large_intestine(4)|lung(10)|ovary(1)|skin(3)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTCCTTCTGCCATTGGTTCT	0.527000													27	58					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5204938	5204938	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:5204938C>T	ENST00000334314.3	-	2	215	c.139G>A	c.(139-141)Gta>Ata	p.V47I						aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						CGGAAGCCTACGTCAATAGCC	0.473000													72	81					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153864220	153864220	+	Missense_Mutation	SNP	T	T	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:153864220T>G	ENST00000511601.1	+	2	199	c.11T>G	c.(10-12)aTg>aGg	p.M4R	FHDC1_ENST00000260008.3_Missense_Mutation_p.M4R			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	4					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					ATGCATGTTATGAATTGTGTC	0.448000													37	32					0	0	1	0	0
CTCF	10664	broad.mit.edu	37	16	67650654	67650654	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:67650654G>A	ENST00000264010.4	+	5	1403	c.959G>A	c.(958-960)cGt>cAt	p.R320H	CTCF_ENST00000401394.1_5'UTR	NM_006565.3	NP_006556.1	P49711	CTCF_HUMAN	CCCTC-binding factor (zinc finger protein)	320					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			breast(6)|central_nervous_system(2)|cervix(1)|endometrium(34)|haematopoietic_and_lymphoid_tissue(7)|kidney(3)|large_intestine(9)|liver(1)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	79		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		CTAGGTACTCGTCCTCACAAG	0.488000													104	124					0	0	1	0	0
AK8	158067	broad.mit.edu	37	9	135702409	135702409	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:135702409C>T	ENST00000298545.3	-	8	1110	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	AK8_ENST00000477396.1_5'UTR	NM_152572.2	NP_689785.1	Q96MA6	KAD8_HUMAN	adenylate kinase 8	197						cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity	p.E197K(2)		NS(1)|kidney(2)|large_intestine(4)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(2)	23						ATTTCAGATTCGGGTGGCCAG	0.542000													105	145					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12334194	12334194	+	Missense_Mutation	SNP	G	G	A	rs148238873		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:12334194G>A	ENST00000261349.4	-	6	1232	c.1156C>T	c.(1156-1158)Cgt>Tgt	p.R386C	LRP6_ENST00000543091.1_Missense_Mutation_p.R386C	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	386	Beta-propeller 2.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				ATAAATGAACGGCGTATGGCC	0.463000													65	94					0	0	1	0	0
KRTAP13-4	284827	broad.mit.edu	37	21	31802764	31802764	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr21:31802764G>T	ENST00000334068.2	+	1	193	c.171G>T	c.(169-171)gaG>gaT	p.E57D		NM_181600.1	NP_853631.1	Q3LI77	KR134_HUMAN	keratin associated protein 13-4	57	4 X 10 AA approximate repeats.					intermediate filament				NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	15						CCTGCTGGGAGCCCGCCAGCT	0.617000													40	38					1.96642e-18	2.15299e-18	1	1	0
MC2R	0	broad.mit.edu	37	18	13885199	13885199	+	Missense_Mutation	SNP	C	C	T	rs104894661		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:13885199C>T	ENST00000327606.3	-	2	499	c.319G>A	c.(319-321)Gac>Aac	p.D107N		NM_000529.2	NP_000520.1	Q01718	ACTHR_HUMAN	melanocortin 2 receptor (adrenocorticotropic hormone)	107			D -> N (in GCCD1).		G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(8)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30					Corticotropin(DB01285)|Cosyntropin(DB01284)	AACAGGGAGTCGATGATGTCA	0.498000													21	38					0	0	1	0	0
SLC6A8	6535	broad.mit.edu	37	X	152960290	152960290	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:152960290C>T	ENST00000253122.5	+	12	2189	c.1713C>T	c.(1711-1713)tgC>tgT	p.C571C	SLC6A8_ENST00000430077.2_Silent_p.C456C|SLC6A8_ENST00000485324.1_3'UTR	NM_001142805.1|NM_005629.3	NP_001136277.1|NP_005620.1	P48029	SC6A8_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 8	571					creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	13	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	CCATGCTGTGCGTGCCGCTGC	0.662000													11	19					0	0	1	0	0
SLC16A10	117247	broad.mit.edu	37	6	111409147	111409147	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:111409147C>T	ENST00000368851.5	+	1	367	c.192C>T	c.(190-192)ccC>ccT	p.P64P		NM_018593.4	NP_061063.2	Q8TF71	MOT10_HUMAN	solute carrier family 16 (aromatic amino acid transporter), member 10	64					aromatic amino acid transport|cellular nitrogen compound metabolic process|ion transport	basolateral plasma membrane|integral to membrane	amino acid transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(2)	12		all_cancers(87;0.00172)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0313)|Colorectal(196;0.0466)		OV - Ovarian serous cystadenocarcinoma(136;0.0703)|Epithelial(106;0.12)|all cancers(137;0.132)		CCCCCGAACCCCCCGAGGGCG	0.731000													16	35					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18499635	18499635	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:18499635A>G	ENST00000433979.1	+	11	1606	c.1490A>G	c.(1489-1491)tAc>tGc	p.Y497C	PIK3C2G_ENST00000535651.1_Missense_Mutation_p.Y497C|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.Y497C|PIK3C2G_ENST00000266497.5_Missense_Mutation_p.Y497C	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	497					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				ATCAATGTCTACTGTAACAGC	0.423000													21	46					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29449848	29449848	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:29449848T>C	ENST00000389048.3	-	18	3913	c.3007A>G	c.(3007-3009)Aag>Gag	p.K1003E	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1003					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CAGATGACCTTGTGGCTTTCA	0.557000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				58	143					0	0	1	0	0
RFC5	5985	broad.mit.edu	37	12	118463610	118463610	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:118463610C>T	ENST00000392542.2	+	8	1110	c.577C>T	c.(577-579)Cgt>Tgt	p.R193C	RFC5_ENST00000229043.3_Missense_Mutation_p.R129C|RFC5_ENST00000454402.2_Missense_Mutation_p.R214C	NM_181578.3	NP_853556.2	P40937	RFC5_HUMAN	replication factor C (activator 1) 5, 36.5kDa	214					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme binding			NS(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGGAGACATGCGTAGGGCTCT	0.423000													38	55					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1265997	1265997	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:1265997G>A	ENST00000447027.1	+	31	7954	c.7896G>A	c.(7894-7896)acG>acA	p.T2632T	MUC5B_ENST00000529681.1_Silent_p.T2629T|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2629	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding	p.T2608T(1)|p.T2629T(1)		cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CGGCACGCACGCTTCCAGTGT	0.637000													57	79					0	0	1	0	0
E4F1	1877	broad.mit.edu	37	16	2282537	2282537	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:2282537C>T	ENST00000301727.4	+	5	738	c.690C>T	c.(688-690)cgC>cgT	p.R230R	E4F1_ENST00000564139.1_Silent_p.R230R|E4F1_ENST00000565090.1_Silent_p.R230R	NM_004424.3	NP_004415.2	Q66K89	E4F1_HUMAN	E4F transcription factor 1	230	Mediates dimerization, DNA-binding, transcription repression of CCNA2 and interaction with HMGA2.				cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						CCTCCTTCCGCACCAAGGGCT	0.692000													12	29					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41000844	41000844	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:41000844C>T	ENST00000352632.3	+	6	714	c.628C>T	c.(628-630)Cgg>Tgg	p.R210W	SPTBN4_ENST00000595535.1_Missense_Mutation_p.R210W|SPTBN4_ENST00000598249.1_Missense_Mutation_p.R210W|SPTBN4_ENST00000344104.3_Missense_Mutation_p.R210W|SPTBN4_ENST00000338932.3_Missense_Mutation_p.R210W			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	210	Actin-binding.|CH 2.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CACCAGCTGGCGGGATGGCTT	0.582000													20	36					0	0	1	0	0
ZNF571	51276	broad.mit.edu	37	19	38056224	38056224	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:38056224C>A	ENST00000328550.2	-	4	1205	c.1106G>T	c.(1105-1107)gGg>gTg	p.G369V	ZNF571-AS1_ENST00000586013.1_RNA|ZNF571_ENST00000358744.3_Missense_Mutation_p.G369V|ZNF571-AS1_ENST00000592392.1_RNA|ZNF571-AS1_ENST00000585578.1_RNA|ZNF571-AS1_ENST00000587121.1_RNA|ZNF571_ENST00000593133.1_Missense_Mutation_p.G369V|ZNF571-AS1_ENST00000591430.1_RNA|ZNF571-AS1_ENST00000589750.1_RNA|ZNF571_ENST00000590751.1_Intron|ZNF540_ENST00000592533.1_Intron|ZNF571-AS1_ENST00000590838.1_RNA|ZNF571-AS1_ENST00000586139.1_RNA|ZNF571_ENST00000451802.2_Missense_Mutation_p.G369V|ZNF571-AS1_ENST00000589802.1_RNA			Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	25			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAAGGTCTTCCCGCATTCTTT	0.393000													15	30					2.31682e-05	2.37644e-05	1	1	0
KIAA0895L	653319	broad.mit.edu	37	16	67212216	67212216	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:67212216G>A	ENST00000290881.7	-	6	1965	c.1039C>T	c.(1039-1041)Cgc>Tgc	p.R347C	KIAA0895L_ENST00000563831.2_5'UTR|KIAA0895L_ENST00000561679.1_Missense_Mutation_p.R192C|KIAA0895L_ENST00000561621.1_Missense_Mutation_p.R347C|KIAA0895L_ENST00000563902.1_Missense_Mutation_p.R347C			Q68EN5	K895L_HUMAN	KIAA0895-like	347										breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|skin(1)	17						AAGGACATGCGCGCGGCGCGG	0.682000													13	8					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101437381	101437381	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:101437381A>G	ENST00000392979.3	+	12	1475	c.1114A>G	c.(1114-1116)Atg>Gtg	p.M372V	ANO4_ENST00000392977.3_Missense_Mutation_p.M407V|ANO4_ENST00000299222.9_5'UTR	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	407						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						CTGTCCATTCATGAGGCTGTC	0.393000										HNSCC(74;0.22)			22	43					0	0	1	0	0
ARX	170302	broad.mit.edu	37	X	25031207	25031207	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:25031207G>T	ENST00000379044.4	-	2	1115	c.905C>A	c.(904-906)gCt>gAt	p.A302D		NM_139058.2	NP_620689.1	Q96QS3	ARX_HUMAN	aristaless related homeobox	302						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(2)|lung(1)	4						CTTGCCCTCAGCGTCTTCCGG	0.697000													5	7					0.0215528	0.0217012	1	1	0
LAMA5	3911	broad.mit.edu	37	20	60927343	60927343	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:60927343G>A	ENST00000252999.3	-	4	708	c.642C>T	c.(640-642)atC>atT	p.I214I	LAMA5_ENST00000370692.3_Silent_p.I214I|LAMA5_ENST00000370677.3_Silent_p.I214I	NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	214	Laminin N-terminal.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGGTGGTGCAGATGGCCGCGT	0.697000													19	54					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45810891	45810891	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr21:45810891G>A	ENST00000397928.1	+	10	1868	c.1423G>A	c.(1423-1425)Gat>Aat	p.D475N	TRPM2_ENST00000300481.9_Missense_Mutation_p.D475N|TRPM2_ENST00000397932.2_Missense_Mutation_p.D475N|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Missense_Mutation_p.D475N	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	475						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GATCTTCATGGATGAGTGGCA	0.582000													58	57					0	0	1	0	0
HTRA4	203100	broad.mit.edu	37	8	38835513	38835513	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:38835513T>C	ENST00000302495.4	+	4	913	c.813T>C	c.(811-813)ctT>ctC	p.L271L		NM_153692.3	NP_710159.1	P83105	HTRA4_HUMAN	HtrA serine peptidase 4	271	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	11		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			CATCTGACCTTCGGGCTGGAG	0.517000													52	168					0	0	1	0	0
ADH4	127	broad.mit.edu	37	4	100045604	100045604	+	Missense_Mutation	SNP	G	G	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:100045604G>T	ENST00000508393.1	-	10	1354	c.1189C>A	c.(1189-1191)Ctc>Atc	p.L397I	RP11-696N14.1_ENST00000500358.2_RNA|ADH4_ENST00000265512.7_Missense_Mutation_p.L378I|ADH4_ENST00000505590.1_Missense_Mutation_p.L397I|ADH4_ENST00000423445.1_Missense_Mutation_p.L397I			P08319	ADH4_HUMAN	alcohol dehydrogenase 4 (class II), pi polypeptide	378					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			NS(1)|cervix(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)|skin(2)	18				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	CAAAAGATGAGGATTGTTCGG	0.323000													3	8					0.00909568	0.00916886	1	1	0
NOTCH3	4854	broad.mit.edu	37	19	15295220	15295220	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:15295220C>T	ENST00000263388.2	-	16	2527	c.2452G>A	c.(2452-2454)Gca>Aca	p.A818T		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	818	EGF-like 21; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.A818S(2)		breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CCACAGGGTGCGGGGCCAGCA	0.612000													23	50					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832912	61832912	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:61832912C>A	ENST00000280772.1	-	37	7918	c.7727G>T	c.(7726-7728)aGg>aTg	p.R2576M	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2576					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CCTGTCCACCCTATCTTCATA	0.423000													37	104					6.53348e-20	7.20737e-20	1	1	0
LRRC1	55227	broad.mit.edu	37	6	53787465	53787465	+	Silent	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:53787465A>G	ENST00000370888.1	+	14	1726	c.1449A>G	c.(1447-1449)ccA>ccG	p.P483P		NM_018214.4	NP_060684.4	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	483						cytoplasm|membrane				cervix(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		CTCCACACCCAGGGGAGTTAA	0.413000													76	217					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70156526	70156526	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:70156526C>A	ENST00000335568.5	+	5	1309	c.1307C>A	c.(1306-1308)cCt>cAt	p.P436H	UGT2B28_ENST00000511240.1_Intron	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	436					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	ATTAATGATCCTTCGTGAGTA	0.398000													48	68					4.86159e-25	5.41756e-25	1	1	0
CANT1	124583	broad.mit.edu	37	17	76989847	76989847	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:76989847C>T	ENST00000302345.2	-	4	1485	c.991G>A	c.(991-993)Gct>Act	p.A331T	CANT1_ENST00000591773.1_Missense_Mutation_p.A331T|CANT1_ENST00000392446.5_Missense_Mutation_p.A331T	NM_001159773.1|NM_138793.3	NP_001153245.1|NP_620148.1	Q8WVQ1	CANT1_HUMAN	calcium activated nucleotidase 1	331					positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to membrane	calcium ion binding|nucleoside-diphosphatase activity|signal transducer activity		CANT1/ETV4(3)	cervix(1)|endometrium(1)|large_intestine(2)|lung(10)|prostate(1)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(99;0.0362)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			TGGCTCACAGCGATGTCGCCG	0.657000			T	ETV4	prostate								28	39					0	0	1	0	0
KLF16	83855	broad.mit.edu	37	19	1854672	1854672	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:1854672G>A	ENST00000250916.4	-	2	615	c.545C>T	c.(544-546)aCg>aTg	p.T182M	KLF16_ENST00000592313.1_5'UTR	NM_031918.3	NP_114124.1	Q9BXK1	KLF16_HUMAN	Kruppel-like factor 16	182						nucleus	DNA binding|zinc ion binding			lung(1)	1		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTCTCGCCCGTGTGCGTCCG	0.687000													34	44					0	0	1	0	0
RTEL1	51750	broad.mit.edu	37	20	62328274	62328274	+	Missense_Mutation	SNP	T	T	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:62328274T>A	ENST00000318100.4	+	36	4888	c.4061T>A	c.(4060-4062)gTg>gAg	p.V1354E	TNFRSF6B_ENST00000369996.1_Missense_Mutation_p.C52S|RTEL1-TNFRSF6B_ENST00000482936.1_Missense_Mutation_p.V1354E			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	0					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GTGCGCCCAGTGCCCCCCAGG	0.701000													32	22					0	0	1	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133958682	133958682	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:133958682G>A	ENST00000298622.4	+	11	1812	c.1674G>A	c.(1672-1674)gcG>gcA	p.A558A	JAKMIP3_ENST00000477275.1_3'UTR	NM_001105521.2	NP_001098991.1			Janus kinase and microtubule interacting protein 3											breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	31		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AGGCCCTGGCGGAGCAGGGGC	0.607000													11	29					0	0	1	0	0
GFOD2	81577	broad.mit.edu	37	16	67709560	67709560	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:67709560C>T	ENST00000268797.7	-	3	1001	c.656G>A	c.(655-657)aGc>aAc	p.S219N	GFOD2_ENST00000602377.1_5'UTR	NM_030819.3	NP_110446.3	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain containing 2	219						proteinaceous extracellular matrix	binding|oxidoreductase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		GAAGTCATCGCTAGTGACGTG	0.577000													31	29					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12693029	12693029	+	Splice_Site	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:12693029T>C	ENST00000380682.1	+	5	974		c.e5+2			NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4						positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CCTTACCCTGTAAGTGTTCTG	0.393000													5	114					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167095958	167095958	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:167095958C>A	ENST00000361200.2	+	6	1756	c.1590C>A	c.(1588-1590)ttC>ttA	p.F530L	DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Missense_Mutation_p.F530L|DUSP27_ENST00000271385.5_Missense_Mutation_p.F530L			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	530					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CCAGTTCCTTCTACAACTTCT	0.542000													47	60					2.24722e-20	2.48213e-20	1	1	0
FGFR2	2263	broad.mit.edu	37	10	123279677	123279677	+	Missense_Mutation	SNP	G	G	C	rs121918498		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:123279677G>C	ENST00000358487.5	-	7	1027	c.755C>G	c.(754-756)tCg>tGg	p.S252W	FGFR2_ENST00000369056.1_Missense_Mutation_p.S252W|FGFR2_ENST00000369061.4_Intron|FGFR2_ENST00000369059.1_Missense_Mutation_p.S137W|FGFR2_ENST00000478859.1_Missense_Mutation_p.S24W|FGFR2_ENST00000457416.2_Missense_Mutation_p.S252W|FGFR2_ENST00000490349.1_5'UTR|FGFR2_ENST00000356226.4_Missense_Mutation_p.S137W|FGFR2_ENST00000360144.3_Missense_Mutation_p.S163W|FGFR2_ENST00000351936.6_Missense_Mutation_p.S252W|FGFR2_ENST00000346997.2_Missense_Mutation_p.S252W|FGFR2_ENST00000357555.5_Missense_Mutation_p.S163W|FGFR2_ENST00000369060.4_Missense_Mutation_p.S252W	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	252			S -> F (in APRS; requires 2 nucleotide substitutions).|S -> L (in CS).|S -> W (in APRS and PS; common mutation).|SP -> FS (in PS).		angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding	p.S252W(68)|p.S163W(13)		breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CCGGTGAGGCGATCGCTCTGG	0.557000	S252W(MFE280_ENDOMETRIUM)	5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				12	27					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138522791	138522791	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:138522791C>T	ENST00000440172.1	-	20	5713	c.5665G>A	c.(5665-5667)Ggc>Agc	p.G1889S	KIAA1549_ENST00000422774.1_Missense_Mutation_p.G1905S|TMEM213_ENST00000413208.1_3'UTR|KIAA1549_ENST00000242365.4_Missense_Mutation_p.G1839S	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1905						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						AGCCCAGGGCCCTGCAGTCCC	0.622000			O	BRAF	pilocytic astrocytoma								13	11					0	0	1	0	0
NUDT5	11164	broad.mit.edu	37	10	12214859	12214859	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:12214859C>T	ENST00000491614.1	-	7	787	c.392G>A	c.(391-393)tGt>tAt	p.C131Y	NUDT5_ENST00000537776.1_Missense_Mutation_p.C131Y|NUDT5_ENST00000378940.3_Missense_Mutation_p.C131Y|NUDT5_ENST00000378927.3_Missense_Mutation_p.C131Y|NUDT5_ENST00000378937.3_Missense_Mutation_p.C144Y|NUDT5_ENST00000378952.3_5'UTR			Q9UKK9	NUDT5_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 5	131	Nudix hydrolase.				D-ribose catabolic process|ribonucleoside diphosphate catabolic process	intracellular	ADP-ribose diphosphatase activity|magnesium ion binding			breast(1)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)	8		Renal(717;0.228)				TGGGTCCATACAGACCGCTGT	0.507000													17	25					0	0	1	0	0
MSX2	4488	broad.mit.edu	37	5	174151740	174151740	+	Silent	SNP	G	G	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:174151740G>C	ENST00000239243.6	+	1	205	c.78G>C	c.(76-78)ccG>ccC	p.P26P	MSX2_ENST00000507785.1_Silent_p.P26P	NM_002449.4	NP_002440.2	P35548	MSX2_HUMAN	msh homeobox 2	26					cranial suture morphogenesis|negative regulation of transcription, DNA-dependent|osteoblast differentiation	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	10	Renal(175;0.000159)|Lung NSC(126;0.0196)|all_lung(126;0.0303)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GACCAGGCCCGGGGCCTGGGG	0.682000													5	20					0	0	1	0	0
GMEB2	26205	broad.mit.edu	37	20	62236098	62236098	+	Missense_Mutation	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:62236098A>G	ENST00000266068.1	-	2	705	c.227T>C	c.(226-228)tTa>tCa	p.L76S	GMEB2_ENST00000370077.1_Missense_Mutation_p.L76S|GMEB2_ENST00000370069.1_Missense_Mutation_p.L25S			Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding protein 2	76					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	18	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			CTTCCTACCTAACACGGCTTC	0.572000													23	128					0	0	1	0	0
RBCK1	10616	broad.mit.edu	37	20	398171	398171	+	Splice_Site	SNP	C	C	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:398171C>G	ENST00000356286.5	+	3	874	c.167_splice	c.e3-1	p.L57_splice	RBCK1_ENST00000353660.3_Splice_Site_p.L15_splice|RBCK1_ENST00000382181.2_5'UTR	NM_031229.2	NP_112506.2	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing 1	57	Interaction with IRF3.|Interaction with TAB2.|Ubiquitin-like.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|lung(4)	5		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				TCTCTGCAGGCTGTGGGTGAG	0.592000													17	58					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62201882	62201882	+	Missense_Mutation	SNP	C	C	T	rs138005803		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:62201882C>T	ENST00000467148.1	-	3	614	c.545G>A	c.(544-546)aGc>aAc	p.S182N	HELZ2_ENST00000479540.1_5'UTR	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		AAACGTCCAGCTGTACTGGGT	0.627000													49	32					0	0	1	0	0
DRD5	0	broad.mit.edu	37	4	9784646	9784646	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:9784646C>T	ENST00000304374.2	+	1	1389	c.993C>T	c.(991-993)gcC>gcT	p.A331A		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	331					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GCCCTCCGGCCGGCTTCCCCT	0.592000													84	84					0	0	1	0	0
FAM160A2	84067	broad.mit.edu	37	11	6238902	6238902	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:6238902C>T	ENST00000265978.4	-	9	2314	c.1956G>A	c.(1954-1956)gtG>gtA	p.V652V	FAM160A2_ENST00000524416.1_Silent_p.V638V|FAM160A2_ENST00000449352.2_Silent_p.V638V	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	638					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ATGATCCTGGCACTCCATTGA	0.672000													18	33					0	0	1	0	0
ATF4P4	0	broad.mit.edu	37	11	113660947	113660947	+	RNA	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:113660947C>T	ENST00000393544.2	+	0	995																											TAAGCCATGGCGCTTCTCAGG	0.592000													5	11					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82837257	82837257	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:82837257T>C	ENST00000265077.3	+	8	9000	c.8435T>C	c.(8434-8436)tTa>tCa	p.L2812S	VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Intron|VCAN_ENST00000342785.4_Intron|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000343200.5_Missense_Mutation_p.L1825S	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2812	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GATACAACATTAGCAGTTTCA	0.458000													88	77					0	0	1	0	0
BUB1B	701	broad.mit.edu	37	15	40502378	40502378	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:40502378G>A	ENST00000287598.6	+	18	2547	c.2352G>A	c.(2350-2352)gcG>gcA	p.A784A	BUB1B_ENST00000412359.3_Silent_p.A798A	NM_001211.5	NP_001202.4	O60566	BUB1B_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase B	784	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(1)|stomach(2)|urinary_tract(2)	36		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TCTGGGTGGCGCCAAGAAACT	0.338000			"""Mis, N, F, S"""			rhabdomyosarcoma			Mosaic Variegated Aneuploidy Syndrome				36	37					0	0	1	0	0
NLRX1	79671	broad.mit.edu	37	11	119044561	119044561	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:119044561C>T	ENST00000409109.1	+	5	1190	c.603C>T	c.(601-603)gaC>gaT	p.D201D	NLRX1_ENST00000292199.2_Silent_p.D201D|NLRX1_ENST00000409991.1_Silent_p.D201D|NLRX1_ENST00000525863.1_Silent_p.D201D|NLRX1_ENST00000409265.4_Silent_p.D201D			Q86UT6	NLRX1_HUMAN	NLR family member X1	201	NACHT.|Required for interaction with MAVS.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CCTGTGAGGACCTGTCATCCC	0.647000													26	45					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35624439	35624439	+	Silent	SNP	T	T	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:35624439T>A	ENST00000400445.3	+	6	1413	c.879T>A	c.(877-879)gcT>gcA	p.A293A	NBEA_ENST00000379939.2_Silent_p.A293A|NBEA_ENST00000310336.4_Silent_p.A293A|NBEA_ENST00000540320.1_Silent_p.A293A	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	293						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GTTACTCTGCTCATTTTGTTG	0.353000													8	8					0	0	1	0	0
RNF39	80352	broad.mit.edu	37	6	30039052	30039052	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:30039052C>T	ENST00000244360.6	-	4	1196	c.1099G>A	c.(1099-1101)Gtg>Atg	p.V367M	RNF39_ENST00000376751.3_Intron	NM_025236.3	NP_079512.2	Q9H2S5	RNF39_HUMAN	ring finger protein 39	367	B30.2/SPRY.					cytoplasm	zinc ion binding										TCCAGGTCCACGCGAATGCGC	0.751000													4	15					0	0	1	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117779388	117779388	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:117779388G>A	ENST00000528626.1	-	8	1189	c.1116C>T	c.(1114-1116)acC>acT	p.T372T	TMPRSS13_ENST00000526090.1_Silent_p.T407T|TMPRSS13_ENST00000524993.1_Silent_p.T407T|TMPRSS13_ENST00000445164.2_Silent_p.T407T|TMPRSS13_ENST00000430170.2_Silent_p.T407T	NM_001206789.1	NP_001193718.1	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	402	Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		CCTCCTCATCGGTGTAATTGC	0.617000													11	5					0	0	1	0	0
GPR78	27201	broad.mit.edu	37	4	8588799	8588799	+	Silent	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:8588799C>A	ENST00000382487.4	+	3	1218	c.801C>A	c.(799-801)ccC>ccA	p.P267P	GPR78_ENST00000509216.1_3'UTR	NM_080819.4	NP_543009.2	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	267					activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|kidney(4)|large_intestine(1)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26						AGCTCGTGCCCTTCGTCACCG	0.652000													24	36					5.45024e-15	5.86486e-15	1	1	0
MAP1S	55201	broad.mit.edu	37	19	17836817	17836817	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:17836817C>T	ENST00000324096.4	+	5	775	c.624C>T	c.(622-624)tgC>tgT	p.C208C	MAP1S_ENST00000597681.1_Intron|MAP1S_ENST00000544059.2_Silent_p.C182C	NM_018174.4	NP_060644.4	Q66K74	MAP1S_HUMAN	microtubule-associated protein 1S	208	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	25						AGGGCCTGTGCGAATTCCTGG	0.716000													13	15					0	0	1	0	0
LPCAT3	10162	broad.mit.edu	37	12	7090985	7090985	+	Silent	SNP	A	A	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:7090985A>T	ENST00000261407.4	-	4	532	c.447T>A	c.(445-447)acT>acA	p.T149T	U47924.19_ENST00000564245.1_RNA	NM_005768.5	NP_005759.4	Q6P1A2	MBOA5_HUMAN	lysophosphatidylcholine acyltransferase 3	149					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	17						TCAGCTTCAAAGTCAGAACAC	0.522000													5	81					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125397363	125397363	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:125397363G>A	ENST00000536769.1	-	1	2531	c.955C>T	c.(955-957)Ctc>Ttc	p.L319F	UBC_ENST00000339647.5_Missense_Mutation_p.L319F|UBC_ENST00000546120.1_Missense_Mutation_p.L243F|UBC_ENST00000538617.1_Intron			P0CG48	UBC_HUMAN	ubiquitin C	319	Ubiquitin-like 5.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		TCCACTTCGAGAGTGATGGTC	0.517000													70	189					0	0	1	0	0
NR2F1	7025	broad.mit.edu	37	5	92929320	92929320	+	Silent	SNP	G	G	A	rs142689077	by1000genomes	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:92929320G>A	ENST00000327111.3	+	3	2731	c.1044G>A	c.(1042-1044)tcG>tcA	p.S348S	NR2F1_ENST00000506162.1_3'UTR	NM_005654.4	NP_005645.1	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	348					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|large_intestine(6)|lung(2)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	21		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		AGGAGAAGTCGCAGTGCGCAC	0.647000													69	110					0	0	1	0	0
EIF4ENIF1	56478	broad.mit.edu	37	22	31836101	31836101	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:31836101T>C	ENST00000397525.1	-	19	2946	c.2723A>G	c.(2722-2724)cAt>cGt	p.H908R	EIF4ENIF1_ENST00000382180.2_Missense_Mutation_p.H563R|EIF4ENIF1_ENST00000397523.1_Missense_Mutation_p.H884R|EIF4ENIF1_ENST00000344710.5_Missense_Mutation_p.H734R|EIF4ENIF1_ENST00000330125.5_Missense_Mutation_p.H908R	NM_001164501.1	NP_001157973.1	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E nuclear import factor 1	908						nucleus	protein binding|protein transporter activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GCCTGGAGGATGCAGAACTGT	0.512000													44	60					0	0	1	0	0
CD37	0	broad.mit.edu	37	19	49841230	49841230	+	Missense_Mutation	SNP	G	G	A	rs147415665		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:49841230G>A	ENST00000535669.2	+	5	505	c.391G>A	c.(391-393)Ggc>Agc	p.G131S	CTC-301O7.4_ENST00000358234.4_lincRNA|CD37_ENST00000598095.1_Missense_Mutation_p.G63S|CD37_ENST00000323906.4_Missense_Mutation_p.G131S|CD37_ENST00000426897.2_Missense_Mutation_p.G63S|CD37_ENST00000596426.1_3'UTR			P11049	CD37_HUMAN	CD37 molecule	131						integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)	11		all_lung(116;2.81e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00088)|GBM - Glioblastoma multiforme(486;0.0443)		CCAAAAGTACGGCACCAACCC	0.642000													22	33					0	0	1	0	0
ANKRD27	84079	broad.mit.edu	37	19	33095253	33095253	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:33095253G>A	ENST00000306065.4	-	25	2729	c.2571C>T	c.(2569-2571)ttC>ttT	p.F857F		NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	857					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity	p.F857F(1)		breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					GCTCTACCACGAAGACGTGCT	0.557000													23	25					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56249561	56249561	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:56249561G>A	ENST00000332836.2	-	1	207	c.180C>T	c.(178-180)gaC>gaT	p.D60D		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	60	DAPIN.					cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		GGTAATGTTTGTCCAGCAGCT	0.468000													248	323					0	0	1	0	0
POU3F2	5454	broad.mit.edu	37	6	99283719	99283719	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:99283719C>T	ENST00000328345.5	+	1	1140	c.970C>T	c.(970-972)Ctg>Ttg	p.L324L		NM_005604.3	NP_005595.2	P20265	PO3F2_HUMAN	POU class 3 homeobox 2	324	POU-specific.				positive regulation of cell proliferation		identical protein binding|sequence-specific DNA binding transcription factor activity	p.L324L(1)		endometrium(2)|large_intestine(3)|lung(5)	10		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0355)		CATGTGCAAGCTGAAGCCTTT	0.587000													237	163					0	0	1	0	0
TAF8	129685	broad.mit.edu	37	6	42036324	42036324	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:42036324C>T	ENST00000372977.3	+	7	777	c.759C>T	c.(757-759)aaC>aaT	p.N253N	TAF8_ENST00000456846.2_Silent_p.N253N|TAF8_ENST00000465926.1_Silent_p.N177N|TAF8_ENST00000494547.1_Silent_p.N253N|TAF8_ENST00000372982.4_Silent_p.N253N	NM_138572.2	NP_612639.2	Q7Z7C8	TAF8_HUMAN	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa	253					cell differentiation|maintenance of protein location in nucleus|positive regulation of transcription, DNA-dependent|regulation of fat cell differentiation|transcription, DNA-dependent	perinuclear region of cytoplasm|transcription factor TFIID complex	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	6	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00179)			ACACAGAGAACCTTGCTCTTC	0.532000													80	212					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	120386010	120386010	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:120386010C>T	ENST00000331113.4	+	5	2609	c.1644C>T	c.(1642-1644)agC>agT	p.S548S		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	548					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					TATCAGGAAGCCATCAAGGTA	0.443000													23	52					0	0	1	0	0
HLA-DMB	3109	broad.mit.edu	37	6	32904929	32904929	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:32904929T>C	ENST00000416244.2	-	3	836	c.642A>G	c.(640-642)ggA>ggG	p.G214G	HLA-DMB_ENST00000418107.2_Intron			P28068	DMB_HUMAN	major histocompatibility complex, class II, DM beta	0	Connecting peptide (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13						CCTAATTCCATCCATCTGCCA	0.507000													5	98					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57428472	57428472	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:57428472C>T	ENST00000371100.4	+	1	704	c.152C>T	c.(151-153)aCc>aTc	p.T51I	GNAS_ENST00000371098.2_Intron|GNAS_ENST00000371099.2_Missense_Mutation_p.T51I|GNAS_ENST00000371102.4_Missense_Mutation_p.T51I|GNAS_ENST00000371075.3_Intron|GNAS_ENST00000313949.7_Intron|GNAS_ENST00000603534.1_Intron|GNAS_ENST00000464624.2_3'UTR	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	0					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GAGATGGAGACCGAACCGCCT	0.652000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			16	4					0	0	1	0	0
SLC25A53	401612	broad.mit.edu	37	X	103349203	103349203	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:103349203C>A	ENST00000357421.4	-	2	918	c.738G>T	c.(736-738)caG>caT	p.Q246H		NM_001012755.3	NP_001012773.2	Q5H9E4	MCAR6_HUMAN	solute carrier family 25, member 53	246					transport	integral to membrane|mitochondrial inner membrane											TTGGCATGTTCTGCCATCCAA	0.527000													24	48					1.22574e-08	1.28894e-08	1	1	0
ATP1A4	480	broad.mit.edu	37	1	160141103	160141103	+	Silent	SNP	G	G	A	rs142215427		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:160141103G>A	ENST00000368081.4	+	11	2025	c.1554G>A	c.(1552-1554)ccG>ccA	p.P518P		NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	518					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGGGTGCTCCGGAGAGGATCT	0.502000													56	62					0	0	1	0	0
JAK3	3718	broad.mit.edu	37	19	17955064	17955064	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:17955064C>T	ENST00000458235.1	-	2	262	c.163G>A	c.(163-165)Gtg>Atg	p.V55M	JAK3_ENST00000534444.1_Missense_Mutation_p.V55M|JAK3_ENST00000527670.1_Missense_Mutation_p.V55M|JAK3_ENST00000526008.1_5'UTR	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	55	FERM.|Interaction with cytokine/interferon/growth hormone receptors (By similarity).				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.V55L(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						GCAGCCTGCACGCACAGGTCC	0.657000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								8	11					0	0	1	0	0
ADCY3	109	broad.mit.edu	37	2	25050931	25050931	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:25050931C>T	ENST00000260600.5	-	13	3123	c.2272G>A	c.(2272-2274)Gcc>Acc	p.A758T	ADCY3_ENST00000450524.1_5'UTR|ADCY3_ENST00000405392.1_Intron	NM_004036.3	NP_004027.2	O60266	ADCY3_HUMAN	adenylate cyclase 3	758					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			NS(1)|breast(5)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(4)|skin(2)	44	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					GACAGCACGGCCACATAGTTG	0.597000											OREG0014498	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	27					0	0	1	0	0
HK2	3099	broad.mit.edu	37	2	75113749	75113749	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:75113749C>T	ENST00000290573.2	+	15	2768	c.2168C>T	c.(2167-2169)aCa>aTa	p.T723I	HK2_ENST00000409174.1_Missense_Mutation_p.T695I	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	723	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						GACTTCCGCACAGAATTTGAT	0.562000													54	80					0	0	1	0	0
SPACA3	124912	broad.mit.edu	37	17	31323957	31323957	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:31323957G>A	ENST00000580599.1	+	4	642	c.233G>A	c.(232-234)aGc>aAc	p.S78N	SPACA3_ENST00000394637.2_3'UTR|SPACA3_ENST00000269053.3_Missense_Mutation_p.S147N|SPACA3_ENST00000394638.1_Missense_Mutation_p.S44N			Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	147					cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			breast(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	18			BRCA - Breast invasive adenocarcinoma(9;0.193)			CAGATCAACAGCCGGAGGTGG	0.607000													61	72					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	183994375	183994375	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:183994375C>T	ENST00000357474.5	+	2	265	c.146C>T	c.(145-147)cCt>cTt	p.P49L	ECE2_ENST00000359140.4_Intron|ECE2_ENST00000404464.3_Intron|EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000402825.3_Intron			O60344	ECE2_HUMAN	endothelin converting enzyme 2	0	Methyltransferase-like region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGGGCTTCCCCTTTCTCACCA	0.687000													7	17					0	0	1	0	0
OAF	220323	broad.mit.edu	37	11	120097673	120097673	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:120097673G>A	ENST00000328965.4	+	3	1028	c.515G>A	c.(514-516)cGc>cAc	p.R172H	OAF_ENST00000531220.1_Missense_Mutation_p.R56H	NM_178507.2	NP_848602.1	Q86UD1	OAF_HUMAN	OAF homolog (Drosophila)	172										kidney(1)|lung(5)	6		Breast(109;0.00663)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)		ATCTACACCCGCCAGGAGGAT	0.647000													27	24					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960123	73960123	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:73960123G>A	ENST00000373468.1	-	3	4920	c.4269C>T	c.(4267-4269)cgC>cgT	p.R1423R	KIAA2022_ENST00000055682.5_Silent_p.R1423R			Q5QGS0	K2022_HUMAN	KIAA2022	1423					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						AGAAGGTAGAGCGAGAGTCCT	0.443000													59	73					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48801143	48801143	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:48801143G>A	ENST00000314191.2	-	35	4402	c.4346C>T	c.(4345-4347)gCt>gTt	p.A1449V	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.A1449V	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	1450					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AGACACAACAGCAGCCAGCCT	0.448000								Non-homologous end-joining					7	15					0	0	1	0	0
TBC1D3P5	0	broad.mit.edu	37	17	25748146	25748146	+	RNA	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:25748146G>A	ENST00000586223.1	+	0	533					NR_033892.1																						GGAACTGCCCGGTCAGAGCCC	0.627000													11	11					0	0	1	0	0
ESX1	80712	broad.mit.edu	37	X	103495020	103495020	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:103495020C>T	ENST00000372588.4	-	4	1193	c.1110G>A	c.(1108-1110)ccG>ccA	p.P370P		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	370	15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.P370P(1)		endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						GCGCCATGGGCGGCCCGGGTG	0.697000													27	37					0	0	1	0	0
CTRB1	1504	broad.mit.edu	37	16	75258615	75258615	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:75258615G>A	ENST00000361017.4	+	7	651	c.643G>A	c.(643-645)Ggc>Agc	p.G215S		NM_001906.4	NP_001897.4			chymotrypsinogen B1											central_nervous_system(1)|lung(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.166)		CGACTCTGGCGGCCCCCTGGT	0.662000													28	40					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116356773	116356773	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:116356773T>C	ENST00000374140.2	+	23	3353	c.3144T>C	c.(3142-3144)ccT>ccC	p.P1048P	RGS3_ENST00000462403.1_Silent_p.P161P|RGS3_ENST00000350696.5_Silent_p.P1048P|RGS3_ENST00000394646.3_Silent_p.P441P|RGS3_ENST00000374134.3_Silent_p.P369P|RGS3_ENST00000462143.1_Silent_p.P369P|RGS3_ENST00000343817.5_Silent_p.P767P|RGS3_ENST00000342620.5_Silent_p.P18P	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	1048					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						CTGGAGCCCCTCCCGCGGGCA	0.587000													35	70					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108165727	108165727	+	Missense_Mutation	SNP	T	T	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:108165727T>G	ENST00000278616.4	+	32	5235	c.4850T>G	c.(4849-4851)cTt>cGt	p.L1617R	ATM_ENST00000452508.2_Missense_Mutation_p.L1617R	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1617					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.E1612_Q1620>*(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CTAAAGGATCTTCGAAGACAA	0.358000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			45	69					0	0	1	0	0
PTBP2	58155	broad.mit.edu	37	1	97235320	97235320	+	Silent	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:97235320T>C	ENST00000236228.6	+	4	259	c.177T>C	c.(175-177)cgT>cgC	p.R59R	PTBP2_ENST00000426398.2_Silent_p.R59R|PTBP2_ENST00000541987.1_Silent_p.R28R|PTBP2_ENST00000370197.1_Silent_p.R59R|PTBP2_ENST00000394184.3_Silent_p.R70R|PTBP2_ENST00000482253.1_3'UTR|PTBP2_ENST00000370198.1_Silent_p.R59R	NM_021190.2	NP_067013.1	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	59	RRM 1.						nucleotide binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|skin(1)	26		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		CTCCTTCTCGTGTACTTCATA	0.343000													45	72					0	0	1	0	0
AHI1	54806	broad.mit.edu	37	6	135811796	135811796	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:135811796T>C	ENST00000367800.4	-	3	316	c.100A>G	c.(100-102)Aag>Gag	p.K34E	AHI1_ENST00000367798.2_Missense_Mutation_p.K34E|AHI1_ENST00000534469.1_Missense_Mutation_p.K34E|AHI1_ENST00000457866.2_Missense_Mutation_p.K34E|AHI1_ENST00000327035.6_Missense_Mutation_p.K34E|AHI1_ENST00000488690.2_Missense_Mutation_p.K34E|AHI1_ENST00000528103.1_Missense_Mutation_p.K34E	NM_001134830.1	NP_001128302.1	Q8N157	AHI1_HUMAN	Abelson helper integration site 1	34						adherens junction|cilium|microtubule basal body				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)	37	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		AGTTTTTTCTTCAGTTTTTTC	0.348000													39	96					0	0	1	0	0
ATP6V0D2	245972	broad.mit.edu	37	8	87165043	87165043	+	Splice_Site	SNP	A	A	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:87165043A>G	ENST00000285393.3	+	8	1033		c.e8-1		CTD-3118D11.2_ENST00000522679.1_RNA	NM_152565.1	NP_689778.1	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(9)|prostate(1)	27						TTCTTTCCTCAGGTACAAATG	0.358000													106	68					0	0	1	0	0
GTDC2	0	broad.mit.edu	37	3	43122426	43122426	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:43122426G>A	ENST00000344697.2	-	2	843	c.498C>T	c.(496-498)caC>caT	p.H166H	GTDC2_ENST00000441964.1_Silent_p.H166H	NM_032806.4	NP_116195.2																					CATGAAAGACGTGCATGAGGT	0.642000													42	62					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144997961	144997961	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:144997961G>A	ENST00000322810.4	-	31	6716	c.6547C>T	c.(6547-6549)Cgg>Tgg	p.R2183W	PLEC_ENST00000356346.3_Missense_Mutation_p.R2032W|PLEC_ENST00000354589.3_Missense_Mutation_p.R2046W|PLEC_ENST00000398774.2_Missense_Mutation_p.R2014W|PLEC_ENST00000436759.2_Missense_Mutation_p.R2073W|PLEC_ENST00000527096.1_Missense_Mutation_p.R2069W|PLEC_ENST00000357649.2_Missense_Mutation_p.R2050W|PLEC_ENST00000345136.3_Missense_Mutation_p.R2046W|PLEC_ENST00000354958.2_Missense_Mutation_p.R2024W	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2183	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GCCTGCAGCCGCTTCTGGGCG	0.701000													5	19					0	0	1	0	0
LZTFL1	54585	broad.mit.edu	37	3	45879420	45879420	+	Splice_Site	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:45879420T>C	ENST00000296135.6	-	2	301	c.128_splice	c.e2+1	p.R43_splice	LZTFL1_ENST00000536047.1_Splice_Site_p.R26_splice|LZTFL1_ENST00000539217.1_Intron|LZTFL1_ENST00000490463.1_5'UTR	NM_001276378.1|NM_020347.2	NP_001263307.1|NP_065080.1	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	43										endometrium(1)|large_intestine(2)|lung(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	8				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		CTCTGATACCTGCTCTCCTTG	0.438000													37	45					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49176478	49176478	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:49176478T>C	ENST00000307885.4	-	1	1434	c.740A>G	c.(739-741)tAc>tGc	p.Y247C	ADCY6_ENST00000550422.1_Missense_Mutation_p.Y247C|ADCY6_ENST00000357869.3_Missense_Mutation_p.Y247C	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	247					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						GTAGGCGATGTAGACAAAGAA	0.662000													5	13					0	0	1	0	0
UBE2G1	7326	broad.mit.edu	37	17	4200057	4200057	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:4200057G>A	ENST00000396981.2	-	3	367	c.202C>T	c.(202-204)Cga>Tga	p.R68*	UBE2G1_ENST00000572484.1_5'UTR	NM_003342.4	NP_003333.1	P62253	UB2G1_HUMAN	ubiquitin-conjugating enzyme E2G 1	68					protein K48-linked ubiquitination|protein K63-linked ubiquitination|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity	p.R68R(1)		large_intestine(2)|lung(4)|skin(1)	7						TTAGGAGGTCGGAGGGGATAA	0.353000													101	170					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48284175	48284175	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:48284175T>C	ENST00000435803.1	+	11	1289	c.1265T>C	c.(1264-1266)tTa>tCa	p.L422S		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	422					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GCCCTCAGATTACAGCATCTG	0.393000													12	23					0	0	1	0	0
EDIL3	10085	broad.mit.edu	37	5	83239262	83239262	+	Silent	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:83239262C>A	ENST00000296591.5	-	11	1837	c.1419G>T	c.(1417-1419)ctG>ctT	p.L473L	EDIL3_ENST00000380138.3_Silent_p.L463L	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	473	F5/8 type C 2.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		TGCAGCCCAGCAGCTCTGACC	0.483000													25	50					4.4004e-07	4.57246e-07	1	1	0
IFIT1	3434	broad.mit.edu	37	10	91163163	91163163	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:91163163G>A	ENST00000546318.1	+	2	2325	c.1038G>A	c.(1036-1038)atG>atA	p.M346I	IFIT1_ENST00000371804.3_Missense_Mutation_p.M377I|LIPA_ENST00000371837.1_Intron	NM_001270928.1|NM_001270929.1|NM_001270930.1	NP_001257857.1|NP_001257858.1|NP_001257859.1	P09914	IFIT1_HUMAN	interferon-induced protein with tetratricopeptide repeats 1	377					cellular response to exogenous dsRNA|intracellular transport of viral proteins in host cell|negative regulation of defense response to virus by host|negative regulation of helicase activity|negative regulation of protein binding|negative regulation of viral genome replication|positive regulation of viral genome replication|response to virus|type I interferon-mediated signaling pathway	cytoplasm	protein binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)	15						AAGAAACAATGCAAGACATAC	0.338000													48	25					0	0	1	0	0
CROT	54677	broad.mit.edu	37	7	86990793	86990793	+	Missense_Mutation	SNP	T	T	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:86990793T>C	ENST00000331536.3	+	5	513	c.328T>C	c.(328-330)Ttt>Ctt	p.F110L	CROT_ENST00000419147.2_Missense_Mutation_p.F138L|CROT_ENST00000442291.1_Missense_Mutation_p.F110L	NM_021151.3	NP_066974.2	Q9UKG9	OCTC_HUMAN	carnitine O-octanoyltransferase	110					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TGCAGCTCATTTTGAACACTA	0.418000													43	67					0	0	1	0	0
KLHL25	64410	broad.mit.edu	37	15	86312497	86312497	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:86312497C>T	ENST00000337975.5	-	2	819	c.545G>A	c.(544-546)aGc>aAc	p.S182N	KLHL25_ENST00000559131.1_Intron|KLHL25_ENST00000536947.1_Missense_Mutation_p.S182N	NM_022480.3	NP_071925.2	Q9H0H3	ENC2_HUMAN	kelch-like family member 25	182						cytoplasm				breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	25						GAAGTCCTCGCTCTGCCTCAC	0.617000													30	36					0	0	1	0	0
MYF6	4618	broad.mit.edu	37	12	81102659	81102659	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:81102659C>T	ENST00000228641.3	+	3	871	c.649C>T	c.(649-651)Cga>Tga	p.R217*		NM_002469.2	NP_002460.1	P23409	MYF6_HUMAN	myogenic factor 6 (herculin)	217					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|skin(1)	26						GAGTAGCCTTCGATGCCTTTC	0.527000													58	51					0	0	1	0	0
TMEM143	55260	broad.mit.edu	37	19	48848477	48848477	+	Silent	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:48848477C>T	ENST00000293261.3	-	4	820	c.504G>A	c.(502-504)ccG>ccA	p.P168P	TMEM143_ENST00000377431.2_Intron|TMEM143_ENST00000435956.3_Silent_p.P133P|TMEM143_ENST00000436660.2_Intron|TMEM143_ENST00000541566.1_Silent_p.P58P	NM_018273.2	NP_060743.2	Q96AN5	TM143_HUMAN	transmembrane protein 143	168						integral to membrane|mitochondrion				endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	14		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		CCTCAGACAGCGGGGAGAAGT	0.622000													67	96					0	0	1	0	0
PIF1	80119	broad.mit.edu	37	15	65110488	65110488	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:65110488C>A	ENST00000268043.4	-	10	1590	c.1496G>T	c.(1495-1497)gGg>gTg	p.G499V	PIF1_ENST00000559239.1_Missense_Mutation_p.G499V|PIF1_ENST00000333425.6_Missense_Mutation_p.G499V			Q9H611	PIF1_HUMAN	PIF1 5'-to-3' DNA helicase	499	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding			kidney(1)|lung(1)	2						AACTACCACCCCTCGGGCACC	0.612000													24	49					1.77063e-15	1.91002e-15	1	1	0
KDM4B	23030	broad.mit.edu	37	19	5131092	5131092	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:5131092G>A	ENST00000159111.4	+	12	1539	c.1321G>A	c.(1321-1323)Ggg>Agg	p.G441R	KDM4B_ENST00000536461.1_Missense_Mutation_p.G475R	NM_015015.2	NP_055830.1	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	441					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						CACAGAGGACGGGAGGGGCAA	0.652000													6	8					0	0	1	0	0
OLFM2	93145	broad.mit.edu	37	19	9964925	9964925	+	Silent	SNP	G	G	A	rs139281596	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:9964925G>A	ENST00000264833.4	-	6	1487	c.1302C>T	c.(1300-1302)aaC>aaT	p.N434N	OLFM2_ENST00000590841.1_Silent_p.N356N	NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	434	Olfactomedin-like.					extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						CCTGGTGGCCGTTGTTCCAGG	0.602000													52	61					0	0	1	0	0
EVA1B	55194	broad.mit.edu	37	1	36788049	36788049	+	Silent	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:36788049C>A	ENST00000270824.1	-	3	636	c.345G>T	c.(343-345)tcG>tcT	p.S115S	EVA1B_ENST00000490466.1_5'UTR|SH3D21_ENST00000474766.1_3'UTR	NM_018166.1	NP_060636.1			eva-1 homolog B (C. elegans)																		GCTCCTCCGCCGACGTGAAGA	0.731000													21	25					2.41591e-17	2.61575e-17	1	1	0
DGKI	9162	broad.mit.edu	37	7	137339501	137339501	+	Translation_Start_Site	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:137339501C>A	ENST00000453654.1	-	0	354				DGKI_ENST00000424189.2_Nonsense_Mutation_p.G239*|DGKI_ENST00000288490.5_Nonsense_Mutation_p.G239*|DGKI_ENST00000446122.1_Nonsense_Mutation_p.G239*			O75912	DGKI_HUMAN	diacylglycerol kinase, iota						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						CTTGAGCCTCCTTCTCGAAAT	0.338000													21	36					1.66031e-10	1.76069e-10	1	1	0
RIMBP2	23504	broad.mit.edu	37	12	130926863	130926863	+	Missense_Mutation	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:130926863G>A	ENST00000261655.4	-	8	1146	c.983C>T	c.(982-984)aCg>aTg	p.T328M	RIMBP2_ENST00000536002.1_Missense_Mutation_p.T236M|RIMBP2_ENST00000535703.1_Missense_Mutation_p.T236M	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	328	Fibronectin type-III 1.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GCTGCTCACCGTTCCCCATCC	0.562000													54	67					0	0	1	0	0
CLGN	1047	broad.mit.edu	37	4	141334145	141334145	+	Missense_Mutation	SNP	C	C	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:141334145C>A	ENST00000325617.5	-	2	528	c.88G>T	c.(88-90)Gac>Tac	p.D30Y	CLGN_ENST00000414773.1_Missense_Mutation_p.D30Y|CLGN_ENST00000537281.1_Missense_Mutation_p.D30Y	NM_004362.2	NP_004353.1	O14967	CLGN_HUMAN	calmegin	30					protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding	p.D30N(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(5)|ovary(2)|prostate(3)|skin(4)|urinary_tract(1)	25	all_hematologic(180;0.162)					TCTTCAAAGTCTTCCGTCTCA	0.328000													11	31					1.58986e-06	1.64812e-06	1	1	0
ZCWPW1	55063	broad.mit.edu	37	7	99998670	99998670	+	Silent	SNP	G	G	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:99998670G>A	ENST00000398027.2	-	18	2161	c.1914C>T	c.(1912-1914)ggC>ggT	p.G638G	ZCWPW1_ENST00000360951.4_3'UTR|ZCWPW1_ENST00000490721.1_Silent_p.G467G|ZCWPW1_ENST00000324725.6_Silent_p.G467G	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	638							zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGAAGTCCTCGCCATCACTGT	0.597000													15	31					0	0	1	0	0
C7	730	broad.mit.edu	37	5	40964971	40964971	+	Nonsense_Mutation	SNP	T	T	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:40964971T>A	ENST00000313164.9	+	14	2237	c.1878T>A	c.(1876-1878)tgT>tgA	p.C626*		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	626	Sushi 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				AAATGCATTGTCAGAGTGAGT	0.398000													59	98					0	0	1	0	0
FLT3LG	0	broad.mit.edu	37	19	49982287	49982287	+	Missense_Mutation	SNP	A	A	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:49982287A>T	ENST00000595510.1	+	5	519	c.218A>T	c.(217-219)gAg>gTg	p.E73V	CTD-3148I10.9_ENST00000599536.1_Intron|FLT3LG_ENST00000204637.2_Missense_Mutation_p.E73V|FLT3LG_ENST00000600429.1_Missense_Mutation_p.E155V|FLT3LG_ENST00000344019.3_Missense_Mutation_p.E155V|FLT3LG_ENST00000595815.1_3'UTR|FLT3LG_ENST00000596435.1_Missense_Mutation_p.E137V|FLT3LG_ENST00000597551.1_Missense_Mutation_p.E155V|FLT3LG_ENST00000594009.1_Missense_Mutation_p.E155V			P49771	FLT3L_HUMAN	fms-related tyrosine kinase 3 ligand	155					positive regulation of cell proliferation|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity			large_intestine(2)|lung(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	10		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00154)|GBM - Glioblastoma multiforme(486;0.0246)		CGGTGCCTGGAGCTGCAGTGT	0.647000													8	11					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33630351	33630351	+	Missense_Mutation	SNP	C	C	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:33630351C>T	ENST00000374316.5	+	9	1818	c.758C>T	c.(757-759)aCg>aTg	p.T253M	ITPR3_ENST00000605930.1_Missense_Mutation_p.T253M			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	253	MIR 3.				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						AAGTTCCTGACGTGTGACGAG	0.632000													25	18					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71491650	71491650	+	Silent	SNP	C	C	T	rs143726902	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:71491650C>T	ENST00000265382.3	+	6	563	c.258C>T	c.(256-258)taC>taT	p.Y86Y	PIP5K1B_ENST00000541509.1_Silent_p.Y86Y	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	86	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		TTAAGACATACGCTCCATTAG	0.373000													28	36					0	0	1	0	0
RPL22	6146	broad.mit.edu	37	1	6257785	6257785	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:6257785delT	ENST00000234875.4	-	2	82	c.44delA	c.(43-45)agfs	p.K16fs	RPL22_ENST00000484532.1_5'UTR|RPL22_ENST00000497965.1_5'UTR	NM_000983.3	NP_000974.1	P35268	RL22_HUMAN	ribosomal protein L22	16					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	heparin binding|RNA binding|structural constituent of ribosome	p.K15fs*5(1)		kidney(1)|large_intestine(2)|lung(2)|skin(1)	6	Ovarian(185;0.0634)	all_cancers(23;2.78e-38)|all_epithelial(116;8.88e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.53e-38)|GBM - Glioblastoma multiforme(13;3.33e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.8e-19)|Colorectal(212;6.8e-08)|COAD - Colon adenocarcinoma(227;8.04e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		AACTTGCTTCTTTTTTTTGCC	0.398			T	RUNX1	"""AML, CML"""								16	22	---	---	---	---					
ERRFI1	54206	broad.mit.edu	37	1	8074168	8074169	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:8074168_8074169delAG	ENST00000377482.5	-	4	713_714	c.490_491delCT	c.(490-492)gfs	p.L164fs	ERRFI1_ENST00000474874.1_Intron|ERRFI1_ENST00000469499.1_3'UTR|ERRFI1_ENST00000467067.1_3'UTR	NM_018948.3	NP_061821.1	Q9UJM3	ERRFI_HUMAN	ERBB receptor feedback inhibitor 1	164					lung alveolus development|lung epithelium development|lung vasculature development|negative regulation of epidermal growth factor receptor activity|negative regulation of protein autophosphorylation|regulation of keratinocyte differentiation|response to stress|skin morphogenesis	cytoplasm|extrinsic to internal side of plasma membrane|nucleus	protein kinase binding|Rho GTPase activator activity			breast(1)|endometrium(2)|large_intestine(3)|liver(3)|lung(3)|ovary(1)|prostate(1)|skin(2)	16	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.33e-70)|GBM - Glioblastoma multiforme(8;8.05e-37)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;6.9e-06)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		TGTGTCATCCAGAGAGAGGGCT	0.475													53	70	---	---	---	---					
SPSB1	80176	broad.mit.edu	37	1	9416315	9416315	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:9416315delC	ENST00000328089.6	+	2	706	c.365delC	c.(364-366)gcfs	p.A122fs	SPSB1_ENST00000377399.2_Frame_Shift_Del_p.A122fs|SPSB1_ENST00000357898.3_Frame_Shift_Del_p.A122fs	NM_025106.3	NP_079382.2	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box containing 1	122	B30.2/SPRY.				intracellular signal transduction	cytoplasm				breast(1)|endometrium(3)|kidney(2)|lung(5)|prostate(2)	13	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		ACGGCAGACGCCCCCCTGCAC	0.657													40	63	---	---	---	---					
DNAJC16	23341	broad.mit.edu	37	1	15873320	15873321	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:15873320_15873321delAT	ENST00000375847.3	+	6	982_983	c.818_819delAT	c.(817-819)cfs	p.H273fs	DNAJC16_ENST00000375838.1_Frame_Shift_Del_p.H273fs|DNAJC16_ENST00000375849.1_Frame_Shift_Del_p.H273fs	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	273					cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AATAAGCCTCATGTCCTTCTGT	0.327													43	83	---	---	---	---					
SZT2	23334	broad.mit.edu	37	1	43909340	43909340	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:43909340delC	ENST00000562955.1	+	61	8527	c.8527delC	c.(8527-8529)ccfs	p.P2844fs	SZT2_ENST00000372442.1_Frame_Shift_Del_p.P2002fs	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2901						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GGATGTGTCGCCCCCGGGAGC	0.577													60	115	---	---	---	---					
CYP4Z2P	0	broad.mit.edu	37	1	47365870	47365870	+	RNA	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:47365870delT	ENST00000505841.1	-	0	180					NR_002788.2																						atatgtgctgttttttttaAT	0.398													11	15	---	---	---	---					
C8A	731	broad.mit.edu	37	1	57373743	57373743	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:57373743delG	ENST00000361249.3	+	9	1433	c.1337delG	c.(1336-1338)tgfs	p.W446fs		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	446	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						TACCGTTCCTGGGGGAGGTCA	0.483													41	43	---	---	---	---					
DAB1	1600	broad.mit.edu	37	1	57537235	57537235	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:57537235delT	ENST00000371236.2	-	6	781	c.518delA	c.(517-519)agfs	p.K173fs	DAB1_ENST00000371230.1_Frame_Shift_Del_p.K173fs|DAB1_ENST00000371234.4_Frame_Shift_Del_p.K173fs|DAB1_ENST00000420954.2_Frame_Shift_Del_p.K173fs|DAB1_ENST00000371231.1_Frame_Shift_Del_p.K173fs|DAB1_ENST00000414851.2_Frame_Shift_Del_p.K173fs|DAB1_ENST00000439789.2_Intron|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	173	PID.				cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						CTTTTGTGCCTTTTTTTCTAA	0.393													18	44	---	---	---	---					
NEXN	91624	broad.mit.edu	37	1	78408251	78408251	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:78408251delA	ENST00000330010.8	+	12	1870	c.1573delA	c.(1573-1575)aafs	p.K525fs	NEXN_ENST00000457030.1_Frame_Shift_Del_p.K575fs|NEXN_ENST00000334785.7_Frame_Shift_Del_p.K589fs|NEXN_ENST00000480732.1_3'UTR	NM_001172309.1	NP_001165780.1	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	589	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				Colorectal(170;0.114)		GAAGCCTCTTAAAAACACATC	0.438													33	57	---	---	---	---					
HFM1	164045	broad.mit.edu	37	1	91845795	91845796	+	Splice_Site	INS	-	-	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:91845795_91845796insA	ENST00000370425.3	-	8	972		c.e8-2		HFM1_ENST00000370424.3_Splice_Site|HFM1_ENST00000294696.5_Splice_Site	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)								ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GTAAAGAAGCTAAAAAATAAAA	0.282													22	49	---	---	---	---					
RP11-343N15.1	0	broad.mit.edu	37	1	121116648	121116648	+	RNA	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:121116648delA	ENST00000437515.1	-	0	329																											GCCCCCCTTTAAAAAAAAAGG	0.398													7	55	---	---	---	---					
PI4KB	5298	broad.mit.edu	37	1	151265430	151265432	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:151265430_151265432delCTC	ENST00000368875.2	-	13	2963_2965	c.2383_2385delGAG	c.(2383-2385)del	p.E795del	PI4KB_ENST00000368873.1_In_Frame_Del_p.E783del|PI4KB_ENST00000271657.5_In_Frame_Del_p.E795del|PI4KB_ENST00000368874.4_In_Frame_Del_p.E768del|PI4KB_ENST00000529142.1_In_Frame_Del_p.E451del|PI4KB_ENST00000368872.1_In_Frame_Del_p.E768del	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	783					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GCTGCAGCTGCTCCTCAGTCATG	0.542													38	55	---	---	---	---					
TCHH	7062	broad.mit.edu	37	1	152082957	152082959	+	In_Frame_Del	DEL	CTC	CTC	-	rs143222885	by1000genomes	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:152082957_152082959delCTC	ENST00000368804.1	-	2	2733_2735	c.2734_2736delGAG	c.(2734-2736)del	p.E912del		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	912	10 X 30 AA tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCTCTGTAGCTCCTCCTCCTCC	0.586													7	286	---	---	---	---					
CRTC2	200186	broad.mit.edu	37	1	153923897	153923898	+	Frame_Shift_Ins	INS	-	-	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:153923897_153923898insG	ENST00000368633.1	-	11	1369_1370	c.1242_1243insC	c.(1240-1245)cccttafs	p.PL414fs	CRTC2_ENST00000368630.3_Frame_Shift_Ins_p.PL94fs	NM_181715.2	NP_859066.1	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	414					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			NS(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	27	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCAGGGTAAGAGGGGGCGCCCA	0.673													10	18	---	---	---	---					
NES	10763	broad.mit.edu	37	1	156642804	156642804	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:156642804delG	ENST00000368223.3	-	4	1308	c.1176delC	c.(1174-1176)ccfs	p.P392fs		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	392	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCTGAGGTGTGGGGGGGATGG	0.597													126	205	---	---	---	---					
ARV1	64801	broad.mit.edu	37	1	231131567	231131567	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr1:231131567delA	ENST00000310256.2	+	4	567	c.510delA	c.(508-510)gcfs	p.A170fs	ARV1_ENST00000366658.2_Frame_Shift_Del_p.A130fs|ARV1_ENST00000497753.1_3'UTR	NM_022786.1	NP_073623.1	Q9H2C2	ARV1_HUMAN	ARV1 homolog (S. cerevisiae)	170					sphingolipid metabolic process	integral to membrane				breast(3)|large_intestine(2)|lung(2)	7	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)		COAD - Colon adenocarcinoma(196;0.211)|Colorectal(1306;0.233)		CCATGACGGCAAAAAAAAAGC	0.383													33	43	---	---	---	---					
ROCK2	9475	broad.mit.edu	37	2	11332603	11332603	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:11332603delT	ENST00000315872.6	-	31	4371	c.3923delA	c.(3922-3924)agfs	p.K1308fs	ROCK2_ENST00000401753.1_Frame_Shift_Del_p.K1065fs	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	1308	PH.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		AATCTCCTCCTTTTTGTCCAT	0.388													34	64	---	---	---	---					
RAD51AP2	729475	broad.mit.edu	37	2	17698825	17698825	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:17698825delT	ENST00000399080.2	-	1	881	c.858delA	c.(856-858)aafs	p.K286fs		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	286										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CATATGCCTCTTTTTTGTCAT	0.353													17	31	---	---	---	---					
ZFP36L2	678	broad.mit.edu	37	2	43452260	43452260	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:43452260delC	ENST00000282388.3	-	2	976	c.683delG	c.(682-684)gcfs	p.G228fs	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	228					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				CCCGGAggcgccccccgacgg	0.706													16	31	---	---	---	---					
ASPRV1	151516	broad.mit.edu	37	2	70188284	70188284	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:70188284delG	ENST00000320256.4	-	1	1113	c.537delC	c.(535-537)ccfs	p.P179fs		NM_152792.2	NP_690005.2	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1	179					protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity	p.P179P(1)		endometrium(3)|large_intestine(4)|lung(6)|ovary(1)	14						GCAGGTGGCTGGGGGCAGCCC	0.587													51	48	---	---	---	---					
C2orf42	54980	broad.mit.edu	37	2	70392681	70392682	+	Frame_Shift_Ins	INS	-	-	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:70392681_70392682insT	ENST00000264434.2	-	7	1609_1610	c.1230_1231insA	c.(1228-1233)aaggctfs	p.A411fs	C2orf42_ENST00000420306.1_Frame_Shift_Ins_p.A411fs	NM_017880.1	NP_060350.1	Q9NWW7	CB042_HUMAN	chromosome 2 open reading frame 42	411										endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	12						TTGGGGAGCCGTTTTTTTGCAC	0.406													29	57	---	---	---	---					
FBXO41	150726	broad.mit.edu	37	2	73490910	73490910	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:73490910delC	ENST00000521871.1	-	8	2386	c.1971delG	c.(1969-1971)ggfs	p.G657fs	FBXO41_ENST00000295133.5_Frame_Shift_Del_p.G718fs|FBXO41_ENST00000520530.2_Frame_Shift_Del_p.G657fs			Q8TF61	FBX41_HUMAN	F-box protein 41	657						intracellular	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)	13						TCAGCAGGTTCCCCCCAGCTG	0.637													13	102	---	---	---	---					
FER1L5	90342	broad.mit.edu	37	2	97363350	97363350	+	RNA	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:97363350delG	ENST00000457909.1	+	0	3637							A0AVI2	FR1L5_HUMAN	fer-1-like 5 (C. elegans)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(9)|large_intestine(9)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	38						GCAGGGAGGTGGGGGGCTGCC	0.547													16	20	---	---	---	---					
SEPT10	151011	broad.mit.edu	37	2	110301827	110301828	+	Frame_Shift_Ins	INS	-	-	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:110301827_110301828insT	ENST00000356688.4	-	12	1821_1822	c.1506_1507insA	c.(1504-1509)aatagafs	p.NR502fs	SEPT10_ENST00000437928.1_3'UTR|SEPT10_ENST00000334001.6_3'UTR|SEPT10_ENST00000397714.2_3'UTR|SEPT10_ENST00000397712.2_3'UTR			Q9P0V9	SEP10_HUMAN	septin 10	0					cell cycle|cell division	septin complex	GTP binding			breast(2)|endometrium(3)|large_intestine(4)|lung(8)|prostate(1)	18						CACACTTCTAGTTTTTTTTTAA	0.317													20	28	---	---	---	---					
NCKAP5	344148	broad.mit.edu	37	2	133543031	133543031	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:133543031delG	ENST00000409261.1	-	14	1726	c.1353delC	c.(1351-1353)ccfs	p.P451fs	NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000317721.6_Frame_Shift_Del_p.P451fs	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	451							protein binding	p.C452fs*21(1)		NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CTGTTTTGCAGGGGGGATACT	0.463													24	21	---	---	---	---					
R3HDM1	23518	broad.mit.edu	37	2	136409480	136409482	+	In_Frame_Del	DEL	CCT	CCT	-	rs139457585		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:136409480_136409482delCCT	ENST00000264160.4	+	17	2171_2173	c.1801_1803delCCT	c.(1801-1803)del	p.P605del	R3HDM1_ENST00000329971.3_In_Frame_Del_p.P476del|R3HDM1_ENST00000409606.1_In_Frame_Del_p.P606del|R3HDM1_ENST00000410054.1_In_Frame_Del_p.P550del|R3HDM1_ENST00000409478.1_In_Frame_Del_p.P477del	NM_015361.2	NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1	605	Poly-Pro.						nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		accaccaccacctcctcctcctc	0.586													38	71	---	---	---	---					
LRP1B	53353	broad.mit.edu	37	2	141819647	141819648	+	Frame_Shift_Ins	INS	-	-	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:141819647_141819648insT	ENST00000389484.3	-	8	2179_2180	c.1208_1209insA	c.(1207-1209)aagfs	p.K403fs		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	403					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGTGTGTCTATTTTTTCCTTG	0.391										TSP Lung(27;0.18)			35	78	---	---	---	---					
GRB14	2888	broad.mit.edu	37	2	165350964	165350964	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:165350964delT	ENST00000263915.3	-	13	1991	c.1453delA	c.(1453-1455)tafs	p.I485fs	GRB14_ENST00000543549.1_Frame_Shift_Del_p.I398fs|GRB14_ENST00000497306.1_Intron	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	485	SH2.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						AAGTGCTTTATTTTTTGTCCA	0.333													26	48	---	---	---	---					
DFNB59	494513	broad.mit.edu	37	2	179325760	179325760	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:179325760delT	ENST00000409117.3	+	7	1174	c.818delT	c.(817-819)ctfs	p.L273fs	DFNB59_ENST00000375129.4_Frame_Shift_Del_p.L273fs	NM_001042702.3	NP_001036167.1	Q0ZLH3	PJVK_HUMAN	deafness, autosomal recessive 59	273					sensory perception of sound			p.L273P(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			TTGGATGATCTTTTTTCTGAC	0.348													20	153	---	---	---	---					
CALCRL	10203	broad.mit.edu	37	2	188250275	188250275	+	Frame_Shift_Del	DEL	A	A	-	rs13391909	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:188250275delA	ENST00000409998.1	-	5	829	c.48delT	c.(46-48)ttfs	p.F16fs	CALCRL_ENST00000392370.3_Frame_Shift_Del_p.F16fs|AC007319.1_ENST00000412276.1_RNA|AC007319.1_ENST00000453517.1_RNA|CALCRL_ENST00000410068.1_Frame_Shift_Del_p.F16fs			Q16602	CALRL_HUMAN	calcitonin receptor-like	16			F -> L (in dbSNP:rs13391909).			integral to plasma membrane				endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			TGCTTACCATAAAAAAAGGCA	0.274													10	12	---	---	---	---					
DNAH7	56171	broad.mit.edu	37	2	196788373	196788374	+	Frame_Shift_Ins	INS	-	-	T	rs34468832		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:196788373_196788374insT	ENST00000312428.6	-	23	3870_3871	c.3770_3771insA	c.(3769-3771)aatfs	p.N1257fs		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1257	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CATCGCTAATATTTTTTTTTAC	0.421													21	46	---	---	---	---					
BZW1	9689	broad.mit.edu	37	2	201683505	201683505	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:201683505delA	ENST00000409600.1	+	9	1302	c.847delA	c.(847-849)aafs	p.K284fs	BZW1_ENST00000452790.2_Frame_Shift_Del_p.K316fs|BZW1_ENST00000409226.1_Frame_Shift_Del_p.K288fs	NM_001207067.1|NM_014670.3	NP_001193996.1|NP_055485.2	Q7L1Q6	BZW1_HUMAN	basic leucine zipper and W2 domains 1	284	W2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	protein binding			breast(1)|kidney(2)|large_intestine(1)|lung(2)	6						GGAGGAGATGAAAAAAAACAA	0.368													20	43	---	---	---	---					
ORC2	4999	broad.mit.edu	37	2	201785020	201785021	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:201785020_201785021delAG	ENST00000234296.2	-	15	1639_1640	c.1390_1391delCT	c.(1390-1392)tfs	p.L465fs		NM_006190.4	NP_006181.1	Q13416	ORC2_HUMAN	origin recognition complex, subunit 2	465					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	20						CTTTACCAGAAGAGAGTTCTCA	0.426													31	60	---	---	---	---					
GPR1	2825	broad.mit.edu	37	2	207041592	207041592	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:207041592delA	ENST00000407325.2	-	3	742	c.380delT	c.(379-381)tcfs	p.F127fs	GPR1_ENST00000437420.1_Frame_Shift_Del_p.F127fs	NM_001098199.1|NM_001261452.1|NM_001261453.1|NM_001261454.1|NM_001261455.1|NM_005279.3	NP_001091669.1|NP_001248381.1|NP_001248382.1|NP_001248383.1|NP_001248384.1|NP_005270.2	P46091	GPR1_HUMAN	G protein-coupled receptor 1	127						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	18		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		CACTGTCAGGAAAAAAACACT	0.458													55	67	---	---	---	---					
SP110	3431	broad.mit.edu	37	2	231072718	231072718	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr2:231072718delT	ENST00000258381.6	-	8	963	c.886delA	c.(886-888)gcfs	p.S296fs	SP110_ENST00000486146.2_5'UTR|SP110_ENST00000338556.3_Frame_Shift_Del_p.S48fs|SP110_ENST00000258382.5_Frame_Shift_Del_p.S296fs|SP110_ENST00000358662.4_Frame_Shift_Del_p.S296fs|SP110_ENST00000540870.1_Frame_Shift_Del_p.S302fs|SP110_ENST00000392048.3_Frame_Shift_Del_p.S296fs	NM_080424.2	NP_536349.2	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	296					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		CCTGGGAGGCTTTTTTTCTTA	0.393													3	6	---	---	---	---					
CNTN6	27255	broad.mit.edu	37	3	1371501	1371501	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:1371501delA	ENST00000446702.2	+	11	1873	c.1246delA	c.(1246-1248)aafs	p.K418fs	CNTN6_ENST00000350110.2_Frame_Shift_Del_p.K418fs|CNTN6_ENST00000539053.1_Frame_Shift_Del_p.K346fs			Q9UQ52	CNTN6_HUMAN	contactin 6	418	Ig-like C2-type 5.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane		p.K418fs*63(1)		breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AAGTCCAGTTAAAAAAAAGTC	0.393													24	45	---	---	---	---					
SEMA3B	7869	broad.mit.edu	37	3	50311871	50311871	+	RNA	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:50311871delC	ENST00000418948.1	+	0	1449							Q13214	SEM3B_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B						axon guidance|cell-cell signaling	endoplasmic reticulum|extracellular region|membrane	receptor activity			central_nervous_system(2)|kidney(1)|lung(2)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CGCGGAACCACCCCCTCATGT	0.587											OREG0015583	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	97	120	---	---	---	---					
COL8A1	1295	broad.mit.edu	37	3	99513775	99513775	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:99513775delC	ENST00000261037.3	+	5	1410	c.1030delC	c.(1030-1032)ccfs	p.P345fs	COL8A1_ENST00000273342.4_Frame_Shift_Del_p.P345fs	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	345	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GCTACCAGGACCCCCAGGCCT	0.622													23	36	---	---	---	---					
CCDC80	151887	broad.mit.edu	37	3	112357095	112357095	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:112357095delT	ENST00000206423.3	-	2	2611	c.1658delA	c.(1657-1659)agfs	p.K553fs	CCDC80_ENST00000439685.2_Frame_Shift_Del_p.K553fs	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	553	Lys-rich.									breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						attcttcatcttttttttctt	0.398													12	29	---	---	---	---					
MCM2	4171	broad.mit.edu	37	3	127323896	127323896	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:127323896delC	ENST00000265056.7	+	4	814	c.570delC	c.(568-570)ggfs	p.G190fs		NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	190	Interaction with MYST2 (By similarity).				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						GCATGGCGGGCCCCCGGCTGG	0.622													38	97	---	---	---	---					
IFT122	55764	broad.mit.edu	37	3	129207227	129207227	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:129207227delA	ENST00000296266.3	+	17	2324	c.2132delA	c.(2131-2133)gafs	p.E711fs	IFT122_ENST00000431818.2_Frame_Shift_Del_p.E510fs|IFT122_ENST00000440957.2_Frame_Shift_Del_p.E451fs|IFT122_ENST00000349441.2_Frame_Shift_Del_p.E549fs|IFT122_ENST00000348417.2_Frame_Shift_Del_p.E660fs|IFT122_ENST00000347300.2_Frame_Shift_Del_p.E601fs|IFT122_ENST00000504021.1_Frame_Shift_Del_p.E554fs|IFT122_ENST00000507564.1_Frame_Shift_Del_p.E652fs	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	660					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						TTAGATTTTGAAACAGCAAAG	0.522													29	48	---	---	---	---					
ASTE1	28990	broad.mit.edu	37	3	130743461	130743461	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:130743461delG	ENST00000264992.3	-	3	1131	c.690delC	c.(688-690)ccfs	p.P230fs	ASTE1_ENST00000514044.1_Frame_Shift_Del_p.P230fs	NM_014065.2	NP_054784.2	Q2TB18	ASTE1_HUMAN	asteroid homolog 1 (Drosophila)	230					DNA repair		nuclease activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)	22						TCTCCATGATGGGTAGATTAA	0.448													28	92	---	---	---	---					
SLC35G2	80723	broad.mit.edu	37	3	136573486	136573486	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:136573486delA	ENST00000446465.2	+	2	812	c.184delA	c.(184-186)aafs	p.K64fs	RP11-85F14.5_ENST00000474250.1_RNA|SLC35G2_ENST00000393079.3_Frame_Shift_Del_p.K64fs|RP11-85F14.5_ENST00000470236.1_RNA|RP11-85F14.5_ENST00000461864.1_RNA	NM_025246.2	NP_079522.2	Q8TBE7	TMM22_HUMAN	solute carrier family 35, member G2	64						Golgi apparatus|integral to membrane											GAGTGAAATGAAAAAAAAAGG	0.413													7	173	---	---	---	---					
GRK7	131890	broad.mit.edu	37	3	141499234	141499234	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:141499234delA	ENST00000264952.2	+	2	768	c.631delA	c.(631-633)aafs	p.K211fs		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	211	Protein kinase.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CGTCCAGGTGAAAAACACTGG	0.458													17	25	---	---	---	---					
LINC00969	0	broad.mit.edu	37	3	195392917	195392917	+	RNA	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr3:195392917delT	ENST00000445430.1	+	0	647																											CTTCTTGCCCTTTTTTTTTCT	0.418													5	4	---	---	---	---					
FRAS1	80144	broad.mit.edu	37	4	79238582	79238583	+	Frame_Shift_Ins	INS	-	-	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:79238582_79238583insC	ENST00000264895.6	+	17	2320_2321	c.1880_1881insC	c.(1879-1881)accfs	p.T627fs	FRAS1_ENST00000264899.6_Frame_Shift_Ins_p.T627fs|FRAS1_ENST00000325942.6_Frame_Shift_Ins_p.T627fs	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	627					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						ACAGCCTGCAGCCCCCCCAAGG	0.574													47	59	---	---	---	---					
INTS12	57117	broad.mit.edu	37	4	106604358	106604360	+	In_Frame_Del	DEL	TGT	TGT	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:106604358_106604360delTGT	ENST00000451321.2	-	7	1398_1400	c.919_921delACA	c.(919-921)del	p.T307del	INTS12_ENST00000394735.1_In_Frame_Del_p.T307del|INTS12_ENST00000340139.5_In_Frame_Del_p.T307del	NM_001142471.1	NP_001135943.1	Q96CB8	INT12_HUMAN	integrator complex subunit 12	307	Ser-rich.				snRNA processing	integrator complex	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		TCAATTTTGCTGTTGAAGGACCA	0.458													42	67	---	---	---	---					
LRBA	987	broad.mit.edu	37	4	151749479	151749479	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:151749479delT	ENST00000535741.1	-	30	5497	c.5024delA	c.(5023-5025)acfs	p.N1675fs	LRBA_ENST00000507224.1_Frame_Shift_Del_p.N1675fs|LRBA_ENST00000510413.1_Frame_Shift_Del_p.N1675fs|LRBA_ENST00000357115.3_Frame_Shift_Del_p.N1675fs			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1675						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					CACATTGACGTTTTTTGAAAC	0.448													30	67	---	---	---	---					
FBXO8	26269	broad.mit.edu	37	4	175160263	175160263	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr4:175160263delA	ENST00000393674.2	-	5	1516	c.654delT	c.(652-654)ttfs	p.F218fs	FBXO8_ENST00000503293.1_Frame_Shift_Del_p.F177fs	NM_012180.2	NP_036312.2	Q9NRD0	FBX8_HUMAN	F-box protein 8	218	SEC7.				regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|urinary_tract(1)	14		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		GGATATGACGAAAAAATTCTC	0.388													24	35	---	---	---	---					
SREK1IP1	285672	broad.mit.edu	37	5	64023941	64023941	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:64023941delT	ENST00000513458.4	-	4	438	c.271delA	c.(271-273)ggfs	p.R91fs		NM_173829.3	NP_776190.1	Q8N9Q2	SR1IP_HUMAN	SREK1-interacting protein 1	91	Lys-rich.				mRNA processing|RNA splicing		nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|ovary(1)	6						TACCttttccttttttttttc	0.264													6	1	---	---	---	---					
SLCO4C1	353189	broad.mit.edu	37	5	101627312	101627313	+	Splice_Site	INS	-	-	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:101627312_101627313insA	ENST00000310954.6	-	2	642		c.e2-2			NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1						cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		CTACAATACCTAAAAAACAGAA	0.312													18	28	---	---	---	---					
WDR55	54853	broad.mit.edu	37	5	140049102	140049102	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140049102delA	ENST00000358337.5	+	7	1252	c.1015delA	c.(1015-1017)aafs	p.K341fs	WDR55_ENST00000520764.1_3'UTR	NM_017706.4	NP_060176.2	Q9H6Y2	WDR55_HUMAN	WD repeat domain 55	341					rRNA processing	cytoplasm|nucleolus		p.K341fs*8(1)		NS(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)	9			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGTCGGCGCAAAAAAAAGGG	0.592													19	20	---	---	---	---					
PCDHB14	0	broad.mit.edu	37	5	140604308	140604309	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr5:140604308_140604309delAG	ENST00000239449.4	+	1	1231_1232	c.1231_1232delAG	c.(1231-1233)afs	p.R411fs	PCDHB14_ENST00000515856.2_Frame_Shift_Del_p.R258fs	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		411	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCACTGGACAGAGAGAGCCAA	0.470													105	115	---	---	---	---					
TUBB2B	347733	broad.mit.edu	37	6	3225652	3225653	+	Frame_Shift_Ins	INS	-	-	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:3225652_3225653insC	ENST00000259818.7	-	4	861_862	c.670_671insG	c.(670-672)cctfs	p.P224fs	TUBB2B_ENST00000473006.1_5'UTR	NM_178012.4	NP_821080.1	Q9BVA1	TBB2B_HUMAN	tubulin, beta 2B class IIb	224					'de novo' posttranslational protein folding|microtubule-based movement|neuron migration|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			kidney(2)|large_intestine(5)|lung(1)|prostate(1)|skin(1)	10	Ovarian(93;0.0386)	all_hematologic(90;0.108)				GTGGTTGAGGTCCCCGTAGGTG	0.614													44	53	---	---	---	---					
RREB1	6239	broad.mit.edu	37	6	7247181	7247181	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:7247181delC	ENST00000379938.2	+	12	5035	c.4498delC	c.(4498-4500)ccfs	p.P1501fs	RREB1_ENST00000349384.6_Frame_Shift_Del_p.P1446fs|RREB1_ENST00000334984.6_Intron|RREB1_ENST00000379933.3_Frame_Shift_Del_p.P1446fs	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	1446					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				GGAGGAGAAGCCCCCCGAGAC	0.746													11	3	---	---	---	---					
DSP	1832	broad.mit.edu	37	6	7583793	7583793	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:7583793delT	ENST00000379802.3	+	24	6639	c.6298delT	c.(6298-6300)ttfs	p.F2100fs	DSP_ENST00000418664.2_Frame_Shift_Del_p.F1501fs	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2100	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGATGATCCATTTTCAGGCAA	0.468													225	156	---	---	---	---					
C6orf10	10665	broad.mit.edu	37	6	32261771	32261772	+	Frame_Shift_Ins	INS	-	-	T	rs560505	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:32261771_32261772insT	ENST00000375015.4	-	26	875_876	c.675_676insA	c.(673-678)aacttgfs	p.N225fs	C6orf10_ENST00000533191.1_Frame_Shift_Ins_p.N224fs|C6orf10_ENST00000442822.2_Frame_Shift_Ins_p.N217fs|C6orf10_ENST00000375007.4_Frame_Shift_Ins_p.N224fs|C6orf10_ENST00000447241.2_Frame_Shift_Ins_p.N226fs|C6orf10_ENST00000527965.1_Frame_Shift_Ins_p.N210fs			Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	226						integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						TTGGAACAAGATTTTTTTGCAA	0.337													61	58	---	---	---	---					
PHIP	55023	broad.mit.edu	37	6	79711725	79711726	+	Frame_Shift_Ins	INS	-	-	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:79711725_79711726insA	ENST00000275034.4	-	17	1936_1937	c.1769_1770insT	c.(1768-1770)tgtfs	p.C590fs		NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	590					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		CAACATCAACCAAAAAAGGGGG	0.426													38	95	---	---	---	---					
ZNF292	23036	broad.mit.edu	37	6	87970974	87970974	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:87970974delA	ENST00000369577.3	+	8	7670	c.7627delA	c.(7627-7629)aafs	p.K2544fs	ZNF292_ENST00000339907.4_Frame_Shift_Del_p.K2539fs	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	2544					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		CTCACAAAATAAAAAAAGGAA	0.358													37	40	---	---	---	---					
EZR	7430	broad.mit.edu	37	6	159188477	159188477	+	Frame_Shift_Del	DEL	G	G	-	rs139613796		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr6:159188477delG	ENST00000367075.3	-	13	1580	c.1412delC	c.(1411-1413)cgfs	p.P476fs	EZR_ENST00000337147.7_Frame_Shift_Del_p.P476fs|EZR_ENST00000392177.4_Frame_Shift_Del_p.P444fs	NM_001111077.1	NP_001104547.1	P15311	EZRI_HUMAN	ezrin	476	Interaction with SCYL3.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding		EZR/ROS1(4)	breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	15		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TGGTGGGGGCGGGGGTGCTGT	0.597			T	ROS1	NSCLC								100	84	---	---	---	---					
ANLN	54443	broad.mit.edu	37	7	36461586	36461588	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:36461586_36461588delCTT	ENST00000265748.2	+	13	2505_2507	c.2284_2286delCTT	c.(2284-2286)del	p.L764del	ANLN_ENST00000396068.2_In_Frame_Del_p.L727del	NM_018685.2	NP_061155.2	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	764	Localization to the cleavage furrow.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			breast(2)|endometrium(5)|kidney(5)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(2)	45						AGCAGAAAGACTTCTTCTAATTG	0.379													37	53	---	---	---	---					
DPY19L2P2	0	broad.mit.edu	37	7	102852609	102852609	+	RNA	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:102852609delT	ENST00000312132.4	-	0	3344																											TAAAAATACCTTTTTAAAGAT	0.259													3	3	---	---	---	---					
RP11-274B21.1	0	broad.mit.edu	37	7	128249447	128249447	+	RNA	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:128249447delT	ENST00000605862.1	+	0	665																											GAGCAAGTGCTTTTTTTTCCC	0.408													8	11	---	---	---	---					
BRAF	673	broad.mit.edu	37	7	140482927	140482927	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:140482927delG	ENST00000288602.6	-	10	1268	c.1208delC	c.(1207-1209)ctfs	p.P403fs		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	403					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TAATGAGGCAGGGGGGGTAGC	0.428		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				15	33	---	---	---	---					
CHPF2	54480	broad.mit.edu	37	7	150935414	150935415	+	Frame_Shift_Ins	INS	-	-	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:150935414_150935415insG	ENST00000035307.2	+	4	3479_3480	c.1966_1967insG	c.(1966-1968)gggfs	p.G656fs	CHPF2_ENST00000495645.1_Frame_Shift_Ins_p.G648fs	NM_019015.1	NP_061888.1	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	656	Gly/Pro-rich.					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(4)|prostate(1)|skin(3)	17						TGACCCCTCCCGGGGGGCTCCT	0.678													16	20	---	---	---	---					
KMT2C	58508	broad.mit.edu	37	7	151873588	151873588	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr7:151873588delA	ENST00000355193.2	-	38	9168	c.8950delT	c.(8950-8952)ctfs	p.S2984fs	KMT2C_ENST00000262189.6_Frame_Shift_Del_p.S2984fs					lysine (K)-specific methyltransferase 2C																		ACACCCTGAGAAAAAACATGG	0.473													30	27	---	---	---	---					
MCPH1	79648	broad.mit.edu	37	8	6289099	6289099	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:6289099delA	ENST00000344683.5	+	4	389	c.313delA	c.(313-315)aafs	p.K107fs	MCPH1_ENST00000522905.1_Frame_Shift_Del_p.K107fs|MCPH1_ENST00000519480.1_Frame_Shift_Del_p.K107fs	NM_024596.3	NP_078872.2	Q8NEM0	MCPH1_HUMAN	microcephalin 1	107						microtubule organizing center			AGPAT5/MCPH1(2)	central_nervous_system(1)|large_intestine(4)|skin(1)	6		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		AAGCCTAATTAAAAAAAAAGT	0.274													103	67	---	---	---	---					
SPAG11B	10407	broad.mit.edu	37	8	7308689	7308690	+	Frame_Shift_Ins	INS	-	-	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:7308689_7308690insG	ENST00000297498.2	-	3	412_413	c.246_247insC	c.(244-249)cccattfs	p.I83fs	SPAG11B_ENST00000458665.1_Intron|SPAG11B_ENST00000398462.2_Intron|SPAG11B_ENST00000359758.5_Intron|SPAG11B_ENST00000528168.1_Frame_Shift_Ins_p.I30fs|SPAG11B_ENST00000361111.2_Intron	NM_016512.3	NP_057596.1	Q08648	SG11B_HUMAN	sperm associated antigen 11B	83					spermatogenesis	extracellular region				large_intestine(2)|lung(3)|urinary_tract(1)	6				COAD - Colon adenocarcinoma(149;0.0162)|READ - Rectum adenocarcinoma(644;0.236)		ATCCTAAATGAGGGTCCTCGAG	0.460													80	65	---	---	---	---					
PSD3	23362	broad.mit.edu	37	8	18729144	18729145	+	Frame_Shift_Ins	INS	-	-	TC			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:18729144_18729145insTC	ENST00000440756.2	-	3	1331_1332	c.1229_1230insGA	c.(1228-1230)gagfs	p.E410fs	PSD3_ENST00000523619.1_Frame_Shift_Ins_p.E345fs|PSD3_ENST00000327040.8_Frame_Shift_Ins_p.E410fs			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	410					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ACCTTTCCCTGTCTCTCTCTGG	0.450													77	64	---	---	---	---					
RP11-380I10.4	0	broad.mit.edu	37	8	28158143	28158144	+	RNA	INS	-	-	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:28158143_28158144insA	ENST00000521731.1	-	0	230																											GGACAACAACTAAAAAAAAAGA	0.322													7	19	---	---	---	---					
GSR	2936	broad.mit.edu	37	8	30539472	30539473	+	Frame_Shift_Ins	INS	-	-	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:30539472_30539473insG	ENST00000221130.5	-	11	1349_1350	c.1259_1260insC	c.(1258-1260)catfs	p.H420fs	GSR_ENST00000537535.1_Frame_Shift_Ins_p.H338fs|GSR_ENST00000546342.1_Frame_Shift_Ins_p.H391fs|GSR_ENST00000541648.1_Frame_Shift_Ins_p.H367fs|GSR_ENST00000414019.1_Frame_Shift_Ins_p.H377fs	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	420					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	CTGTCCCAATAGGGGGGTGGCT	0.441													26	126	---	---	---	---					
ADAM32	203102	broad.mit.edu	37	8	39068767	39068767	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:39068767delA	ENST00000379907.4	+	12	1284	c.1157delA	c.(1156-1158)cafs	p.Q386fs	ADAM32_ENST00000437682.2_Intron|ADAM32_ENST00000519315.1_Intron	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	386					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			CCACAAATGCAAAAAAAATCT	0.383													10	31	---	---	---	---					
AP3M2	10947	broad.mit.edu	37	8	42022614	42022614	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:42022614delG	ENST00000518421.1	+	6	900	c.609delG	c.(607-609)cafs	p.Q203fs	AP3M2_ENST00000174653.3_Frame_Shift_Del_p.Q203fs|AP3M2_ENST00000396926.3_Frame_Shift_Del_p.Q203fs|AP3M2_ENST00000520685.1_Intron|AP3M2_ENST00000517922.1_Frame_Shift_Del_p.Q203fs	NM_001134296.1	NP_001127768.1	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	203	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus				endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|prostate(1)|stomach(1)	17	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			CTGAGATCCAGGGGGTGATTG	0.443													19	89	---	---	---	---					
PRKDC	5591	broad.mit.edu	37	8	48701554	48701555	+	Frame_Shift_Ins	INS	-	-	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:48701554_48701555insT	ENST00000314191.2	-	77	10867_10868	c.10811_10812insA	c.(10810-10812)aatfs	p.N3604fs	PRKDC_ENST00000338368.3_Frame_Shift_Ins_p.N3604fs|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	3605					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TTTTTTCAATGTTTTTTTTATT	0.401								Non-homologous end-joining					22	121	---	---	---	---					
SOX17	64321	broad.mit.edu	37	8	55371765	55371766	+	Frame_Shift_Ins	INS	-	-	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:55371765_55371766insG	ENST00000297316.4	+	2	659_660	c.455_456insG	c.(454-456)gggfs	p.G152fs		NM_022454.3	NP_071899.1	Q9H6I2	SOX17_HUMAN	SRY (sex determining region Y)-box 17	152					angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)	18		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			AAGCGGGTGGAGGGCGGCTTCC	0.743													21	7	---	---	---	---					
CHD7	55636	broad.mit.edu	37	8	61778453	61778454	+	Frame_Shift_Ins	INS	-	-	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:61778453_61778454insG	ENST00000423902.2	+	38	9434_9435	c.8955_8956insG	c.(8953-8958)gaggggfs	p.EG2985fs	CHD7_ENST00000524602.1_Frame_Shift_Ins_p.EG936fs	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2985					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			ACTCACTTGATGGGGGGGATGA	0.446													18	16	---	---	---	---					
NCOA2	10499	broad.mit.edu	37	8	71056964	71056964	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:71056964delT	ENST00000452400.2	-	13	2906	c.2725delA	c.(2725-2727)gtfs	p.S909fs	NCOA2_ENST00000267974.4_Intron	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	909					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GAGTAGGGACTACTGTTTCTG	0.468			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								43	102	---	---	---	---					
ZFPM2	23414	broad.mit.edu	37	8	106815052	106815052	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:106815052delA	ENST00000407775.2	+	8	2992	c.2742delA	c.(2740-2742)atfs	p.I914fs	ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000520492.1_Frame_Shift_Del_p.I782fs|ZFPM2_ENST00000517361.1_Frame_Shift_Del_p.I782fs|ZFPM2_ENST00000378472.4_Frame_Shift_Del_p.I645fs|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000521622.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	914					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GAAGCATAATAAAATGTGAGA	0.453													42	20	---	---	---	---					
SNTB1	6641	broad.mit.edu	37	8	121561041	121561041	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:121561041delA	ENST00000395601.3	-	6	1708	c.1294delT	c.(1294-1296)gcfs	p.C432fs	SNTB1_ENST00000517992.1_Frame_Shift_Del_p.C432fs	NM_021021.3	NP_066301.1	Q13884	SNTB1_HUMAN	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	432	PH 2.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(6)	24	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			GAATTGTGGCAACCCTGTACT	0.507													8	112	---	---	---	---					
SQLE	6713	broad.mit.edu	37	8	126011893	126011893	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:126011893delC	ENST00000265896.5	+	1	1146	c.248delC	c.(247-249)tcfs	p.S83fs	SQLE_ENST00000523430.1_Intron	NM_003129.3	NP_003120.2	Q14534	ERG1_HUMAN	squalene epoxidase	83					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome	flavin adenine dinucleotide binding|squalene monooxygenase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	14	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)		Butenafine(DB01091)|Naftifine(DB00735)|Terbinafine(DB00857)	TGGGCCAAATCCCCCCCTGAA	0.547													38	31	---	---	---	---					
EPPK1	83481	broad.mit.edu	37	8	144947314	144947314	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:144947314delG	ENST00000525985.1	-	2	179	c.108delC	c.(106-108)ccfs	p.P36fs				P58107	EPIPL_HUMAN	epiplakin 1	36						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCTGGGGCCTGGGGGGCGTGC	0.697													38	123	---	---	---	---					
ARHGAP39	80728	broad.mit.edu	37	8	145773375	145773375	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr8:145773375delG	ENST00000276826.5	-	4	1296	c.1095delC	c.(1093-1095)ccfs	p.P365fs	ARHGAP39_ENST00000377307.2_Frame_Shift_Del_p.P365fs|ARHGAP39_ENST00000540274.1_Frame_Shift_Del_p.P365fs			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	365	Pro-rich.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						GGCAGGGCGAGGGGGGGCCCT	0.701													20	51	---	---	---	---					
TYRP1	7306	broad.mit.edu	37	9	12702411	12702414	+	Frame_Shift_Del	DEL	ACAA	ACAA	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:12702411_12702414delACAA	ENST00000388918.5	+	5	1183_1186	c.1054_1057delACAA	c.(1054-1059)acfs	p.TN352fs	TYRP1_ENST00000381137.2_Frame_Shift_Del_p.TN62fs|TYRP1_ENST00000381136.2_Frame_Shift_Del_p.TN62fs|RP11-3L8.3_ENST00000417638.1_RNA	NM_000550.2	NP_000541.1	P17643	TYRP1_HUMAN	tyrosinase-related protein 1	352					melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity	p.N353fs*31(2)		NS(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|stomach(1)	22		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		TTCCAACTCTACAAACAGTTTCCG	0.387									Oculocutaneous Albinism				14	24	---	---	---	---					
ADAMTSL1	92949	broad.mit.edu	37	9	18829843	18829843	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:18829843delC	ENST00000380548.4	+	23	4456	c.4117delC	c.(4117-4119)ccfs	p.P1374fs	ADAMTSL1_ENST00000380545.5_Frame_Shift_Del_p.P75fs	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1374						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		TCTCACAGATCCCCCCCAAGT	0.567													36	51	---	---	---	---					
NFX1	0	broad.mit.edu	37	9	33294897	33294897	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:33294897delA	ENST00000379540.3	+	2	567	c.505delA	c.(505-507)aafs	p.K170fs	NFX1_ENST00000318524.6_Frame_Shift_Del_p.K170fs|NFX1_ENST00000379521.4_Frame_Shift_Del_p.K170fs	NM_002504.4	NP_002495.2	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	170					inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		AGCAAAACCCAAAAAAGCAAC	0.483													31	64	---	---	---	---					
ALDH1A1	216	broad.mit.edu	37	9	75545849	75545849	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:75545849delC	ENST00000297785.3	-	3	312	c.258delG	c.(256-258)ggfs	p.G86fs	ALDH1A1_ENST00000482210.1_5'UTR|ALDH1A1_ENST00000376939.1_Frame_Shift_Del_p.G86fs	NM_000689.4	NP_000680.2	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1 family, member A1	86					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)	17					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	ATAATAGTCGCCCCCTCTCGG	0.498													58	88	---	---	---	---					
SPATA31D1	389763	broad.mit.edu	37	9	84607691	84607692	+	Frame_Shift_Ins	INS	-	-	G	rs34942699		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:84607691_84607692insG	ENST00000344803.2	+	4	2353_2354	c.2306_2307insG	c.(2305-2307)gggfs	p.G769fs		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		ATGGAGAATGTGGGGAATTATC	0.480													48	48	---	---	---	---					
UGCG	7357	broad.mit.edu	37	9	114695179	114695180	+	Frame_Shift_Ins	INS	-	-	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:114695179_114695180insT	ENST00000374279.3	+	9	1537_1538	c.1087_1088insT	c.(1087-1089)tttfs	p.F363fs		NM_003358.1	NP_003349.1	Q16739	CEGT_HUMAN	UDP-glucose ceramide glucosyltransferase	363					epidermis development|glucosylceramide biosynthetic process	Golgi membrane|integral to membrane|membrane fraction	ceramide glucosyltransferase activity	p.I363V(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|ovary(1)|urinary_tract(1)	12				OV - Ovarian serous cystadenocarcinoma(323;0.0433)	Miglustat(DB00419)	GACAATATACATTTTTTTGTCT	0.401													19	119	---	---	---	---					
VAV2	7410	broad.mit.edu	37	9	136633624	136633626	+	In_Frame_Del	DEL	CAC	CAC	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:136633624_136633626delCAC	ENST00000371851.1	-	27	2822_2824	c.2497_2499delGTG	c.(2497-2499)del	p.V833del	VAV2_ENST00000406606.3_In_Frame_Del_p.V804del|VAV2_ENST00000371850.3_In_Frame_Del_p.V843del			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	843	SH3 2.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		TGTAGATCCTCACCACGTCACCC	0.650													36	83	---	---	---	---					
QSOX2	169714	broad.mit.edu	37	9	139107074	139107074	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:139107074delG	ENST00000358701.5	-	10	1323	c.1286delC	c.(1285-1287)cgfs	p.P429fs		NM_181701.3	NP_859052.3	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2	429	ERV/ALR sulfhydryl oxidase.				cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		GAGAGAACACGGGTAACCCCT	0.458													17	43	---	---	---	---					
NPDC1	56654	broad.mit.edu	37	9	139935633	139935633	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr9:139935633delC	ENST00000371600.3	-	2	1172	c.500delG	c.(499-501)gcfs	p.G167fs	NPDC1_ENST00000371601.4_Frame_Shift_Del_p.G89fs|NPDC1_ENST00000488145.1_5'UTR			Q9NQX5	NPDC1_HUMAN	neural proliferation, differentiation and control, 1	89	Pro/Ser/Thr-rich.					integral to membrane				NS(1)|large_intestine(1)|lung(1)|prostate(1)|urinary_tract(1)	5	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		CTGGGGCCGGCCCCCGCCTGG	0.687													4	3	---	---	---	---					
LARP4B	23185	broad.mit.edu	37	10	890939	890939	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:890939delT	ENST00000316157.3	-	5	527	c.487delA	c.(487-489)cafs	p.T163fs		NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	163	HTH La-type RNA-binding.						nucleotide binding|RNA binding	p.T163P(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						AATTCCAATGTTTTTTTAAGT	0.353													52	64	---	---	---	---					
RBM17	84991	broad.mit.edu	37	10	6139070	6139070	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:6139070delA	ENST00000446108.1	+	2	686	c.42delA	c.(40-42)tcfs	p.S14fs	RBM17_ENST00000379888.4_Frame_Shift_Del_p.S14fs	NM_001145547.1	NP_001139019.1	Q96I25	SPF45_HUMAN	RNA binding motif protein 17	14					mRNA processing|RNA splicing	spliceosomal complex	nucleotide binding|protein binding|RNA binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	19						CCAGTGACTCAAAAACAGAAG	0.463													54	127	---	---	---	---					
KIAA1217	56243	broad.mit.edu	37	10	24832391	24832391	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:24832391delG	ENST00000376451.2	+	14	3501	c.3241delG	c.(3241-3243)ggfs	p.G1081fs	KIAA1217_ENST00000376454.3_Frame_Shift_Del_p.G1398fs|KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000396446.1_Intron|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000458595.1_Intron			Q5T5P2	SKT_HUMAN	KIAA1217	1398					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						TCTTTCCAGTGGGGAGGTGCA	0.458													41	54	---	---	---	---					
ARHGAP21	57584	broad.mit.edu	37	10	24874838	24874838	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:24874838delT	ENST00000396432.2	-	26	4866	c.4380delA	c.(4378-4380)aafs	p.K1460fs		NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1459					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						TCTCACTTTCTTTTTTGGACT	0.393													70	129	---	---	---	---					
GPR158	57512	broad.mit.edu	37	10	25861746	25861746	+	Frame_Shift_Del	DEL	G	G	-	rs138208272		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:25861746delG	ENST00000376351.3	+	7	2042	c.1683delG	c.(1681-1683)cafs	p.Q561fs		NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	561						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						TTATTGGCCAGGGGAAAACAT	0.453													24	41	---	---	---	---					
PTCHD3	374308	broad.mit.edu	37	10	27702951	27702951	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:27702951delG	ENST00000438700.3	-	1	346	c.229delC	c.(229-231)ggfs	p.R77fs		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	77					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						ATCGACGGCCGGGGGGGTGCA	0.716													7	99	---	---	---	---					
GLUD1P2	0	broad.mit.edu	37	10	48980053	48980053	+	RNA	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:48980053delA	ENST00000594520.1	+	0	864																											aaaattatacaaaaaaaaaaG	0.443													4	5	---	---	---	---					
ANK3	288	broad.mit.edu	37	10	61831290	61831290	+	Frame_Shift_Del	DEL	T	T	-	rs28932171	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:61831290delT	ENST00000280772.1	-	37	9540	c.9349delA	c.(9349-9351)tcfs	p.I3118fs	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3118					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGACTTATGATTTTTTTTACA	0.403													78	187	---	---	---	---					
C10orf54	64115	broad.mit.edu	37	10	73511467	73511467	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:73511467delG	ENST00000394957.3	-	6	914	c.856delC	c.(856-858)tgfs	p.L286fs	CDH23_ENST00000224721.6_Intron	NM_022153.1	NP_071436.1	Q9H7M9	GI24_HUMAN	chromosome 10 open reading frame 54	286						integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	9						GGAGGAGACAGGGGGGTGCTG	0.617													29	72	---	---	---	---					
MYOZ1	58529	broad.mit.edu	37	10	75393728	75393728	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:75393728delT	ENST00000359322.4	-	5	962	c.598delA	c.(598-600)tgfs	p.M200fs		NM_021245.3	NP_067068.1	Q9NP98	MYOZ1_HUMAN	myozenin 1	200					myofibril assembly	nucleus|pseudopodium	FATZ binding			central_nervous_system(1)|large_intestine(5)|lung(2)|ovary(2)|skin(2)	12	Prostate(51;0.0112)					CCAAGTTCCATTTTTTGCTGG	0.517													47	141	---	---	---	---					
PTEN	5728	broad.mit.edu	37	10	89717674	89717675	+	Frame_Shift_Ins	INS	-	-	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:89717674_89717675insC	ENST00000371953.3	+	7	2056_2057	c.699_700insC	c.(697-702)cggggafs	p.RG233fs	PTEN_ENST00000472832.1_3'UTR	NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	233	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.R55fs*1(5)|p.R234fs*11(3)|p.N212fs*1(2)|p.Y27fs*1(2)|p.R234fs*24(1)|p.G165_*404del(1)|p.?(1)|p.R234fs*10(1)|p.R233fs*10(1)|p.R234fs*27(1)|p.R234W(1)|p.R234fs*23(1)|p.R233fs*12(1)|p.R233fs*20(1)|p.R234fs*3(1)|p.R234fs*26(1)|p.R234fs*4(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GACCCACACGACGGGAAGACAA	0.416		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			43	112	---	---	---	---					
TM9SF3	56889	broad.mit.edu	37	10	98336475	98336475	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:98336475delT	ENST00000371142.4	-	2	430	c.214delA	c.(214-216)gtfs	p.S72fs		NM_020123.3	NP_064508.3	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3	72						integral to membrane	binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)	15		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		TGACTGATACTTTTTTTTGAC	0.363													66	141	---	---	---	---					
SORCS3	22986	broad.mit.edu	37	10	106976790	106976790	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:106976790delG	ENST00000369701.3	+	19	2871	c.2644delG	c.(2644-2646)tgfs	p.V882fs	SORCS3_ENST00000369699.4_Frame_Shift_Del_p.V168fs	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	882	PKD.					integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CATCAAGCACGTGTATAAGAG	0.517													32	76	---	---	---	---					
ADRA2A	150	broad.mit.edu	37	10	112837856	112837856	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:112837856delG	ENST00000280155.2	+	1	1067	c.102delG	c.(100-102)ccfs	p.P34fs		NM_000681.3	NP_000672.3	P08913	ADA2A_HUMAN	adrenoceptor alpha 2A	19					actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding	p.G22fs*>430(1)		breast(1)|cervix(3)|endometrium(6)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	CCGAggcgccggggggcggcg	0.726													5	10	---	---	---	---					
TCF7L2	6934	broad.mit.edu	37	10	114900983	114900984	+	Frame_Shift_Ins	INS	-	-	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:114900983_114900984insC	ENST00000355995.4	+	6	1100_1101	c.593_594insC	c.(592-594)cccfs	p.P198fs	TCF7L2_ENST00000349937.2_Frame_Shift_Ins_p.P198fs|TCF7L2_ENST00000543371.1_Frame_Shift_Ins_p.P198fs|TCF7L2_ENST00000352065.5_Frame_Shift_Ins_p.P175fs|TCF7L2_ENST00000542695.1_5'UTR|TCF7L2_ENST00000355717.4_Frame_Shift_Ins_p.P222fs|TCF7L2_ENST00000536810.1_Frame_Shift_Ins_p.P198fs|TCF7L2_ENST00000538897.1_Frame_Shift_Ins_p.P198fs|TCF7L2_ENST00000369395.1_Frame_Shift_Ins_p.P223fs|TCF7L2_ENST00000534894.1_Frame_Shift_Ins_p.P198fs|TCF7L2_ENST00000369397.4_Frame_Shift_Ins_p.P175fs|TCF7L2_ENST00000545257.1_Frame_Shift_Ins_p.P198fs			Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 (T-cell specific, HMG-box)	198	Pro-rich.				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding		VTI1A/TCF7L2(8)	central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(24)|liver(2)|lung(8)|ovary(1)|skin(1)	41		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		CACCATGTCCACCCCCTCACGC	0.569			T	VTI1A	colorectal								43	140	---	---	---	---					
ATRNL1	26033	broad.mit.edu	37	10	117226764	117226765	+	Splice_Site	INS	-	-	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:117226764_117226765insA	ENST00000355044.3	+	23	3622		c.e23+2		ATRNL1_ENST00000423111.2_Splice_Site|ATRNL1_ENST00000303745.7_Intron	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1							integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GTTCAACAGGTAAAAAAATGTT	0.287													14	37	---	---	---	---					
RAB11FIP2	22841	broad.mit.edu	37	10	119768725	119768725	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:119768725delG	ENST00000355624.3	-	5	1762	c.1323delC	c.(1321-1323)ccfs	p.P441fs	RAB11FIP2_ENST00000476207.1_5'UTR|RAB11FIP2_ENST00000369199.3_Frame_Shift_Del_p.P461fs	NM_014904.2	NP_055719.1	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2 (class I)	441	FIP-RBD.				protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(8)	19		Colorectal(252;0.235)		all cancers(201;0.0238)		TGGCATCAAAGGGGTTGCTGT	0.428													11	155	---	---	---	---					
PWWP2B	170394	broad.mit.edu	37	10	134218255	134218255	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr10:134218255delC	ENST00000305233.5	+	2	310	c.251delC	c.(250-252)tcfs	p.S84fs	PWWP2B_ENST00000368609.4_Frame_Shift_Del_p.S84fs	NM_138499.3	NP_612508.3	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2B	84										central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|urinary_tract(1)	9		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		GGGTCCAGCTCCCCCCCTCCT	0.746													7	123	---	---	---	---					
LRP4	4038	broad.mit.edu	37	11	46912011	46912011	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:46912011delG	ENST00000378623.1	-	14	1974	c.1732delC	c.(1732-1734)gtfs	p.R578fs		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	578					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		GCCTCAATACGGGGGGTGTTG	0.542											OREG0020948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	35	---	---	---	---					
PACSIN3	29763	broad.mit.edu	37	11	47200457	47200457	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:47200457delG	ENST00000539589.1	-	9	1367	c.1025delC	c.(1024-1026)cgfs	p.P342fs	PACSIN3_ENST00000298838.6_Frame_Shift_Del_p.P342fs	NM_001184975.1	NP_001171904.1	Q9UKS6	PACN3_HUMAN	protein kinase C and casein kinase substrate in neurons 3	342					endocytosis|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis	cytoplasm|plasma membrane	cytoskeletal protein binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)	11						TGGGGACCCCGGGGACTGGGG	0.602													28	62	---	---	---	---					
OR4C6	219432	broad.mit.edu	37	11	55432816	55432816	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:55432816delT	ENST00000314259.3	+	1	203	c.174delT	c.(172-174)tafs	p.Y58fs		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						CACCTATGTATTTTTTTCTTA	0.423													57	92	---	---	---	---					
DTX4	23220	broad.mit.edu	37	11	58958609	58958609	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:58958609delA	ENST00000227451.3	+	5	1286	c.1182delA	c.(1180-1182)ctfs	p.L394fs	DTX4_ENST00000532982.1_Frame_Shift_Del_p.L288fs|DTX4_ENST00000531902.1_3'UTR	NM_015177.1	NP_055992.1	Q9Y2E6	DTX4_HUMAN	deltex homolog 4 (Drosophila)	394					Notch signaling pathway	cytoplasm	zinc ion binding	p.K290fs*34(1)		central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	20		all_epithelial(135;0.125)				AGGAAGTGCTAAAAAAATATC	0.502													5	5	---	---	---	---					
INPPL1	3636	broad.mit.edu	37	11	71948748	71948748	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:71948748delC	ENST00000541756.1	+	26	3664	c.2734delC	c.(2734-2736)ccfs	p.P913fs	INPPL1_ENST00000298229.2_Frame_Shift_Del_p.P1155fs|INPPL1_ENST00000538751.1_Frame_Shift_Del_p.P913fs			O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1155					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						GGAGCTGCAGCCCCCCCGGGG	0.697													12	35	---	---	---	---					
INPPL1	3636	broad.mit.edu	37	11	71948755	71948755	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:71948755delG	ENST00000541756.1	+	26	3671	c.2741delG	c.(2740-2742)cgfs	p.R914fs	INPPL1_ENST00000298229.2_Frame_Shift_Del_p.R1156fs|INPPL1_ENST00000538751.1_Frame_Shift_Del_p.R914fs			O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1156					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						CAGCCCCCCCGGGGACTGCCC	0.697													16	29	---	---	---	---					
XRRA1	143570	broad.mit.edu	37	11	74554923	74554923	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:74554923delG	ENST00000340360.6	-	18	2432	c.2101delC	c.(2101-2103)ggfs	p.R701fs	XRRA1_ENST00000321448.8_Frame_Shift_Del_p.R426fs|XRRA1_ENST00000527087.1_Intron	NM_182969.2	NP_892014.1	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	701					response to X-ray	cytoplasm|nucleus				breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(3)	20						GTAATGTTCCGGGGATCCCGC	0.557													11	14	---	---	---	---					
FOLH1B	219595	broad.mit.edu	37	11	89403521	89403522	+	RNA	INS	-	-	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:89403521_89403522insT	ENST00000532352.1	+	0	908							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						GTTTTGTTTTGTTTTTTTTCAA	0.332													9	20	---	---	---	---					
CEP57	9702	broad.mit.edu	37	11	95552024	95552026	+	In_Frame_Del	DEL	GAA	GAA	-	rs142615007		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:95552024_95552026delGAA	ENST00000325542.5	+	6	893_895	c.655_657delGAA	c.(655-657)del	p.E221del	CEP57_ENST00000537677.1_In_Frame_Del_p.E194del|CEP57_ENST00000325486.5_In_Frame_Del_p.E221del|CEP57_ENST00000541150.1_In_Frame_Del_p.E212del|CEP57_ENST00000538658.1_In_Frame_Del_p.E221del	NM_001243776.1|NM_014679.4	NP_001230705.1|NP_055494.2	Q86XR8	CEP57_HUMAN	centrosomal protein 57kDa	221	centrosome localization domain (CLD) (By similarity).				fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AAAACTCCATGAAGAAGAACAGG	0.345									Mosaic Variegated Aneuploidy Syndrome				23	37	---	---	---	---					
TECTA	7007	broad.mit.edu	37	11	120983885	120983885	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr11:120983885delC	ENST00000392793.1	+	5	862	c.591delC	c.(589-591)gafs	p.D197fs	TECTA_ENST00000264037.2_Frame_Shift_Del_p.D197fs			O75443	TECTA_HUMAN	tectorin alpha	197	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GTGGCGGCGACCCCCTGACAG	0.582											OREG0021430	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	75	---	---	---	---					
CACNA1C	775	broad.mit.edu	37	12	2614074	2614074	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:2614074delT	ENST00000399655.1	+	8	1445	c.1180delT	c.(1180-1182)ttfs	p.F395fs	CACNA1C_ENST00000399621.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399595.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399591.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399638.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000402845.3_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399617.1_Intron|CACNA1C_ENST00000480911.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000347598.4_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399644.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399601.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399603.1_Intron|CACNA1C_ENST00000399629.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399641.1_Intron|CACNA1C_ENST00000491104.1_Intron|CACNA1C_ENST00000399597.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000335762.5_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000327702.7_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000344100.3_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000406454.3_Intron|CACNA1C_ENST00000399634.1_Intron|CACNA1C_ENST00000399649.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399606.1_Frame_Shift_Del_p.F395fs|CACNA1C_ENST00000399637.1_Frame_Shift_Del_p.F395fs	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	395					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CATAGGGTCATTTTTTGTACT	0.403													18	26	---	---	---	---					
PLEKHA5	54477	broad.mit.edu	37	12	19427544	19427545	+	Frame_Shift_Ins	INS	-	-	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:19427544_19427545insA	ENST00000538714.1	+	10	926_927	c.922_923insA	c.(922-924)aaafs	p.K308fs	PLEKHA5_ENST00000317589.4_Frame_Shift_Ins_p.K308fs|PLEKHA5_ENST00000355397.3_Frame_Shift_Ins_p.K308fs|PLEKHA5_ENST00000299275.6_Frame_Shift_Ins_p.K308fs|PLEKHA5_ENST00000543806.1_Frame_Shift_Ins_p.K200fs|PLEKHA5_ENST00000510738.2_3'UTR|PLEKHA5_ENST00000424268.1_Frame_Shift_Ins_p.K200fs|PLEKHA5_ENST00000429027.2_Frame_Shift_Ins_p.K314fs|PLEKHA5_ENST00000359180.3_Frame_Shift_Ins_p.K308fs|PLEKHA5_ENST00000309364.4_Frame_Shift_Ins_p.K308fs|PLEKHA5_ENST00000539256.1_Frame_Shift_Ins_p.K66fs	NM_001143821.2	NP_001137293.2	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A member 5	308							1-phosphatidylinositol binding|protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					CCAAAACAATCAAAAAAACAAG	0.327													23	29	---	---	---	---					
KIF21A	55605	broad.mit.edu	37	12	39745622	39745623	+	Frame_Shift_Ins	INS	-	-	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:39745622_39745623insT	ENST00000395670.3	-	11	2048_2049	c.1629_1630insA	c.(1627-1632)aaatttfs	p.F544fs	KIF21A_ENST00000541463.2_Frame_Shift_Ins_p.F544fs|KIF21A_ENST00000544797.2_Frame_Shift_Ins_p.F544fs|KIF21A_ENST00000361961.3_Frame_Shift_Ins_p.F544fs|KIF21A_ENST00000361418.5_Frame_Shift_Ins_p.F544fs			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	544					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				TTCTCTAAATCTTTTTTTGCTA	0.337													32	44	---	---	---	---					
HDAC7	51564	broad.mit.edu	37	12	48181527	48181527	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:48181527delG	ENST00000080059.7	-	21	2420	c.2421delC	c.(2419-2421)ccfs	p.P807fs	HDAC7_ENST00000354334.3_Frame_Shift_Del_p.P770fs|HDAC7_ENST00000427332.2_Frame_Shift_Del_p.P768fs|HDAC7_ENST00000380610.4_Frame_Shift_Del_p.P824fs|HDAC7_ENST00000552960.1_Frame_Shift_Del_p.P790fs	NM_015401.3	NP_056216.2	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7	768	Histone deacetylase.				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25				GBM - Glioblastoma multiforme(48;0.137)		GATCCCCCATGGGGGGGTCCA	0.622													11	9	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49434073	49434074	+	Frame_Shift_Ins	INS	-	-	C	rs10747559	by1000genomes	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:49434073_49434074insC	ENST00000301067.7	-	31	7478_7479	c.7479_7480insG	c.(7477-7482)ggtcccfs	p.P2494fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GCTGCTGGGAACCCCCCAGCCC	0.653													25	64	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49440431	49440431	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:49440431delG	ENST00000301067.7	-	15	4378	c.4379delC	c.(4378-4380)cafs	p.P1460fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGTGAGCAGTGGGGGGTCCAG	0.562													52	123	---	---	---	---					
RNF41	10193	broad.mit.edu	37	12	56600292	56600293	+	Frame_Shift_Ins	INS	-	-	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:56600292_56600293insC	ENST00000345093.4	-	7	1261_1262	c.892_893insG	c.(892-894)tgafs	p.*298fs	RNF41_ENST00000394013.2_Frame_Shift_Ins_p.*227fs|RNF41_ENST00000552656.1_Frame_Shift_Ins_p.*298fs	NM_005785.3|NM_194359.2	NP_005776.1|NP_919340.1	Q9H4P4	RNF41_HUMAN	ring finger protein 41	298					apoptosis|induction of apoptosis|protein polyubiquitination|regulation of reactive oxygen species metabolic process		protein binding|protein tag|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|large_intestine(2)|lung(1)|skin(2)|urinary_tract(1)	11						CACCATGTCATCCCCCATGTGC	0.515											OREG0021921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	128	143	---	---	---	---					
MDM1	56890	broad.mit.edu	37	12	68724964	68724964	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:68724964delT	ENST00000303145.7	-	2	142	c.56delA	c.(55-57)agfs	p.K19fs	MDM1_ENST00000393543.3_Frame_Shift_Del_p.K19fs|MDM1_ENST00000411698.2_Frame_Shift_Del_p.K19fs|MDM1_ENST00000430606.2_Frame_Shift_Del_p.K19fs|MDM1_ENST00000540418.1_5'UTR|MDM1_ENST00000545724.1_5'UTR	NM_017440.4	NP_059136.2	Q8TC05	MDM1_HUMAN	Mdm1 nuclear protein homolog (mouse)	19						nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(7)	33			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		CAAATAAGACTTTTTCCACAG	0.423													56	82	---	---	---	---					
SUDS3	64426	broad.mit.edu	37	12	118814517	118814522	+	In_Frame_Del	DEL	GGCCCC	GGCCCC	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:118814517_118814522delGGCCCC	ENST00000543473.1	+	1	333_338	c.21_26delGGCCCC	c.(19-27)ctg>ct	p.LAP7del	SUDS3_ENST00000397564.2_In_Frame_Del_p.LAP7del	NM_022491.2	NP_071936.2	Q9H7L9	SDS3_HUMAN	suppressor of defective silencing 3 homolog (S. cerevisiae)	7					chromatin modification|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	Sin3 complex	histone deacetylase binding			breast(1)|lung(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGGGGCTGCTGGCCCCGGCCCCGGCC	0.743													5	9	---	---	---	---					
P2RX2	0	broad.mit.edu	37	12	133196264	133196264	+	Splice_Site	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr12:133196264delG	ENST00000389110.3	+	3	346		c.e3-1		P2RX2_ENST00000348800.5_Splice_Site|P2RX2_ENST00000350048.5_Intron|P2RX2_ENST00000343948.4_Splice_Site|P2RX2_ENST00000352418.4_Intron|P2RX2_ENST00000351222.4_Intron|P2RX2_ENST00000449132.2_Intron	NM_170682.2|NM_170683.2|NM_174873.1	NP_733782.1|NP_733783.1|NP_777362.1	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 2						positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity			NS(1)|breast(1)|kidney(2)|large_intestine(2)|liver(2)|lung(8)|ovary(1)|prostate(3)	20	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)		TCTGAGCCCAGGGGGGCAGCG	0.756													25	33	---	---	---	---					
POSTN	10631	broad.mit.edu	37	13	38144790	38144790	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:38144790delT	ENST00000379747.4	-	19	2313	c.2196delA	c.(2194-2196)aafs	p.K732fs	POSTN_ENST00000379749.4_Frame_Shift_Del_p.K732fs|POSTN_ENST00000379743.4_Frame_Shift_Del_p.K705fs|POSTN_ENST00000379742.4_Frame_Shift_Del_p.K675fs|POSTN_ENST00000497145.1_5'UTR|POSTN_ENST00000541481.1_Intron|POSTN_ENST00000541179.1_Frame_Shift_Del_p.K705fs	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	732					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TTTTGGTGTATTTTTTAATAA	0.343													32	63	---	---	---	---					
ZC3H13	23091	broad.mit.edu	37	13	46543691	46543691	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:46543691delT	ENST00000242848.4	-	14	3336	c.2988delA	c.(2986-2988)aafs	p.K996fs	ZC3H13_ENST00000282007.3_Frame_Shift_Del_p.K996fs|ZC3H13_ENST00000378921.2_5'UTR			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	996	Lys-rich.						nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TTTTCTGTCCTTTTTTTGGTG	0.333													8	73	---	---	---	---					
MYCBP2	23077	broad.mit.edu	37	13	77844149	77844149	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:77844149delT	ENST00000407578.2	-	7	1504	c.1238delA	c.(1237-1239)agfs	p.K413fs	MYCBP2_ENST00000544440.2_Frame_Shift_Del_p.K375fs|MYCBP2_ENST00000357337.6_Frame_Shift_Del_p.K375fs|MYCBP2_ENST00000360084.5_5'UTR	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	375					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TAACCAAGACTTTTTTTCTTT	0.289													60	99	---	---	---	---					
RP11-811P12.3	0	broad.mit.edu	37	13	103054139	103054139	+	RNA	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:103054139delC	ENST00000418923.2	-	0	331																											AATGATTTATCCCCCCTCGAT	0.418													2	4	---	---	---	---					
ERCC5	2073	broad.mit.edu	37	13	103524612	103524612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr13:103524612delA	ENST00000355739.4	+	13	4166	c.2743delA	c.(2743-2745)aafs	p.K917fs	BIVM-ERCC5_ENST00000602836.1_Frame_Shift_Del_p.1340fs|ERCC5_ENST00000375954.1_Frame_Shift_Del_p.K150fs	NM_000123.3	NP_000114.2			excision repair cross-complementing rodent repair deficiency, complementation group 5											breast(3)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	51	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CACCAAAGTGAAAAAAAAATT	0.428			"""Mis, N, F"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				32	35	---	---	---	---					
OR4K13	390433	broad.mit.edu	37	14	20502375	20502375	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:20502375delA	ENST00000315693.2	-	1	544	c.543delT	c.(541-543)ctfs	p.L181fs		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	181					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TCACAAGGGGAAGGTCACAGA	0.483													29	71	---	---	---	---					
TRAV12-3	0	broad.mit.edu	37	14	22433683	22433684	+	RNA	INS	-	-	T			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:22433683_22433684insT	ENST00000390442.3	+	0	4_5																											GTTTGTTATTATTTTTTTTTCG	0.351													16	22	---	---	---	---					
RP11-159L20.2	0	broad.mit.edu	37	14	31291082	31291082	+	RNA	DEL	A	A	-	rs111525555		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:31291082delA	ENST00000554665.1	-	0	208																											AATTAAAAAGAAAAAAAAAAC	0.313													8	4	---	---	---	---					
NKX2-1	7080	broad.mit.edu	37	14	36987157	36987157	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:36987157delC	ENST00000518149.1	-	3	1047	c.442delG	c.(442-444)acfs	p.D148fs	RP11-896J10.3_ENST00000521945.1_RNA|NKX2-1_ENST00000498187.2_Frame_Shift_Del_p.D148fs|NKX2-1_ENST00000354822.5_Frame_Shift_Del_p.D178fs|NKX2-1_ENST00000522719.2_Frame_Shift_Del_p.D148fs			P43699	NKX21_HUMAN	NK2 homeobox 1	148					epithelial tube branching involved in lung morphogenesis|globus pallidus development|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|thyroid gland development		protein binding|transcription regulatory region DNA binding			large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(2)	7	all_cancers(3;4.47e-51)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.165)		Lung(8;1.8e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.014)|all cancers(34;0.0366)|LUSC - Lung squamous cell carcinoma(13;0.132)	GBM - Glioblastoma multiforme(112;0.0171)		TTGCTCACGTCCCCCAGCGAG	0.687			A		NSCLC								13	26	---	---	---	---					
SNAPC1	6617	broad.mit.edu	37	14	62242911	62242911	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:62242911delT	ENST00000216294.4	+	5	737	c.633delT	c.(631-633)gafs	p.D211fs	RP11-618G20.1_ENST00000555937.1_RNA	NM_003082.3	NP_003073.1	Q16533	SNPC1_HUMAN	small nuclear RNA activating complex, polypeptide 1, 43kDa	211	SNAPC4-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding	p.D214fs*1(2)		endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)	13				OV - Ovarian serous cystadenocarcinoma(108;0.0639)|BRCA - Breast invasive adenocarcinoma(234;0.186)		TAAAGGATGATTTTTTTGACA	0.358													19	32	---	---	---	---					
SIPA1L1	26037	broad.mit.edu	37	14	72054754	72054755	+	Frame_Shift_Ins	INS	-	-	C	rs12884638	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:72054754_72054755insC	ENST00000555818.1	+	2	513_514	c.165_166insC	c.(163-168)ggccccfs	p.GP55fs	SIPA1L1_ENST00000381232.3_Frame_Shift_Ins_p.GP55fs|SIPA1L1_ENST00000358550.2_Frame_Shift_Ins_p.GP55fs	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	55					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CTCCTGTAGGACCCCCCCGAAG	0.535													56	90	---	---	---	---					
ELMSAN1	91748	broad.mit.edu	37	14	74205773	74205773	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:74205773delG	ENST00000286523.5	-	2	1721	c.939delC	c.(937-939)ccfs	p.P313fs	ELMSAN1_ENST00000394071.2_Frame_Shift_Del_p.P313fs	NM_194278.3	NP_919254.2			ELM2 and Myb/SANT-like domain containing 1																		TATCTGGGTTGGGGGGGAAGG	0.662													16	20	---	---	---	---					
YLPM1	56252	broad.mit.edu	37	14	75248388	75248388	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:75248388delC	ENST00000325680.7	+	4	1766	c.1642delC	c.(1642-1644)ccfs	p.P549fs	YLPM1_ENST00000238571.3_Intron|YLPM1_ENST00000552421.1_Frame_Shift_Del_p.P549fs	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	356					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		ACCAGTGATGCCCCCTGCCCT	0.577													26	357	---	---	---	---					
CDC42BPB	9578	broad.mit.edu	37	14	103447224	103447224	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:103447224delA	ENST00000361246.2	-	8	1314	c.1026delT	c.(1024-1026)ttfs	p.F342fs		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	342	Protein kinase.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity	p.E343fs*1(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TTAGACCTTCAAAAAACGCAT	0.458													45	78	---	---	---	---					
EXOC3L4	91828	broad.mit.edu	37	14	103573972	103573973	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:103573972_103573973delCT	ENST00000380069.3	+	9	1782_1783	c.1706_1707delCT	c.(1705-1707)afs	p.T569fs		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	569										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						GCCCAGGAGACTCTGCAGGAGG	0.703													8	14	---	---	---	---					
KIF26A	26153	broad.mit.edu	37	14	104642560	104642560	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr14:104642560delC	ENST00000315264.7	+	11	3396	c.3018delC	c.(3016-3018)ggfs	p.G1006fs	KIF26A_ENST00000423312.2_Frame_Shift_Del_p.G1145fs			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1145					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		ACCCTGGGGGCCCCCCTGCCC	0.711													10	15	---	---	---	---					
RP11-566K19.6	0	broad.mit.edu	37	15	23114116	23114116	+	RNA	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:23114116delA	ENST00000557922.1	-	0	243					NR_040057.1																						TACATACCCTAAAAAAAAGCC	0.363													3	6	---	---	---	---					
HERC2P2	0	broad.mit.edu	37	15	23331163	23331163	+	RNA	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:23331163delA	ENST00000560464.1	-	0	908																											AATAAATACTAAAAAAAAAAA	0.368													4	2	---	---	---	---					
SNHG14	0	broad.mit.edu	37	15	25310193	25310193	+	RNA	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:25310193delA	ENST00000549804.2	+	0	538				SNHG14_ENST00000551077.1_RNA|SNORD116-6_ENST00000384711.1_RNA																							TGAGTCCTCCAAAAAAAACAT	0.473													43	74	---	---	---	---					
ARHGAP11A	9824	broad.mit.edu	37	15	32916446	32916446	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:32916446delT	ENST00000361627.3	+	4	1092	c.370delT	c.(370-372)ttfs	p.F125fs	ARHGAP11A_ENST00000565905.1_5'UTR|ARHGAP11A_ENST00000543522.1_5'UTR|ARHGAP11A_ENST00000567348.1_Frame_Shift_Del_p.F125fs|ARHGAP11A_ENST00000563864.1_Frame_Shift_Del_p.F125fs	NM_014783.3	NP_055598.1	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A	125	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TCTTAAGCAGTTTTTTAGGGA	0.398													22	19	---	---	---	---					
EMC7	56851	broad.mit.edu	37	15	34393991	34393993	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:34393991_34393993delAGC	ENST00000256545.4	-	1	156_158	c.48_50delGCT	c.(46-51)cta>ct	p.LL16del	EMC7_ENST00000532113.1_5'UTR	NM_020154.2	NP_064539.1			ER membrane protein complex subunit 7																		ATCCCCCGATAGCAGCAGCAGCA	0.665													9	294	---	---	---	---					
RASGRP1	10125	broad.mit.edu	37	15	38795505	38795505	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:38795505delT	ENST00000310803.5	-	11	1573	c.1396delA	c.(1396-1398)ccfs	p.T466fs	RASGRP1_ENST00000450598.2_Intron|RASGRP1_ENST00000558164.1_Intron|RP11-102L12.2_ENST00000560231.1_RNA|RASGRP1_ENST00000559830.1_Intron|RASGRP1_ENST00000561180.1_Frame_Shift_Del_p.T517fs|RASGRP1_ENST00000539159.1_Frame_Shift_Del_p.T418fs	NM_001128602.1|NM_005739.3	NP_001122074.1|NP_005730.2	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	466					cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TTGCTAATGGTTTTTGGATCA	0.443													12	16	---	---	---	---					
VPS13C	54832	broad.mit.edu	37	15	62174867	62174868	+	Frame_Shift_Ins	INS	-	-	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:62174867_62174868insA	ENST00000261517.5	-	69	9624_9625	c.9551_9552insT	c.(9550-9552)ttcfs	p.F3184fs	VPS13C_ENST00000249837.3_Frame_Shift_Ins_p.F3141fs|VPS13C_ENST00000395898.3_Frame_Shift_Ins_p.F3141fs|VPS13C_ENST00000395896.4_Frame_Shift_Ins_p.F3184fs	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	3184					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						GAATTCCTGATAAAAAGTCTCG	0.371													35	49	---	---	---	---					
USP3	9960	broad.mit.edu	37	15	63829242	63829242	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:63829242delA	ENST00000268049.7	+	4	429	c.105delA	c.(103-105)gcfs	p.A35fs	USP3_ENST00000540797.1_Intron|USP3_ENST00000539772.1_Intron|USP3_ENST00000536001.1_Frame_Shift_Del_p.A57fs|USP3_ENST00000380324.3_Frame_Shift_Del_p.A57fs|USP3_ENST00000558285.1_Frame_Shift_Del_p.A40fs			Q9Y6I4	UBP3_HUMAN	ubiquitin specific peptidase 3	57					DNA repair|histone deubiquitination|mitotic cell cycle|regulation of protein stability|ubiquitin-dependent protein catabolic process	nuclear chromatin	histone binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			endometrium(3)|large_intestine(7)|lung(4)	14				GBM - Glioblastoma multiforme(80;0.0187)		ATGGCCATGCAAAAAAACATT	0.299													10	18	---	---	---	---					
MTFMT	123263	broad.mit.edu	37	15	65312544	65312544	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:65312544delC	ENST00000220058.4	-	5	725	c.712delG	c.(712-714)cgfs	p.A238fs		NM_139242.3	NP_640335.2	Q96DP5	FMT_HUMAN	mitochondrial methionyl-tRNA formyltransferase	238						mitochondrion	methionyl-tRNA formyltransferase activity|methyltransferase activity			endometrium(1)|large_intestine(3)|lung(3)|ovary(3)	10					Tetrahydrofolic acid(DB00116)	CCGTAAGTCGCCCCCTCCATT	0.408													19	35	---	---	---	---					
CALML4	91860	broad.mit.edu	37	15	68486389	68486389	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:68486389delA	ENST00000448060.2	-	4	525	c.414delT	c.(412-414)ttfs	p.F138fs	CALML4_ENST00000395465.3_3'UTR|RP11-315D16.2_ENST00000562767.1_3'UTR|CALML4_ENST00000467889.1_Frame_Shift_Del_p.F185fs|CALML4_ENST00000540479.1_Frame_Shift_Del_p.F109fs	NM_001031733.2	NP_001026903.2	Q96GE6	CALL4_HUMAN	calmodulin-like 4	185	EF-hand 3.						calcium ion binding			large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	4						TCTTGTGGATAAATTCATCAT	0.403													40	40	---	---	---	---					
UACA	55075	broad.mit.edu	37	15	70959372	70959372	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr15:70959372delT	ENST00000322954.6	-	16	3836	c.3651delA	c.(3649-3651)aafs	p.K1217fs	UACA_ENST00000539319.1_Frame_Shift_Del_p.K1108fs|UACA_ENST00000379983.2_Frame_Shift_Del_p.K1204fs|UACA_ENST00000560441.1_Frame_Shift_Del_p.K1202fs	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	1217						cytoskeleton|extracellular region				breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						TAGTCTCTAATTTTTTTAATG	0.348													33	68	---	---	---	---					
C16orf62	57020	broad.mit.edu	37	16	19710892	19710894	+	In_Frame_Del	DEL	CAA	CAA	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:19710892_19710894delCAA	ENST00000438132.3	+	30	3030_3032	c.2982_2984delCAA	c.(2980-2985)cgc>cg	p.RN994del	C16orf62_ENST00000543152.1_In_Frame_Del_p.RN654del|C16orf62_ENST00000542263.1_In_Frame_Del_p.RN901del|C16orf62_ENST00000448695.1_In_Frame_Del_p.RN755del|C16orf62_ENST00000417362.2_In_Frame_Del_p.RN812del|C16orf62_ENST00000251143.5_In_Frame_Del_p.RN905del	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	905						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						GGGACCTACGCAACAACAAGCTC	0.596													36	70	---	---	---	---					
RRN3P1	0	broad.mit.edu	37	16	21811980	21811980	+	RNA	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:21811980delT	ENST00000546471.1	-	0	1831																											TGCTATACTCTTTTTAAAGCA	0.303													14	21	---	---	---	---					
ERN2	10595	broad.mit.edu	37	16	23711986	23711986	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:23711986delG	ENST00000256797.4	-	13	1711	c.1543delC	c.(1543-1545)tgfs	p.L515fs	ERN2_ENST00000457008.2_Frame_Shift_Del_p.L415fs	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	467					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GCAGGTGCCAGGGGGGTCTCC	0.627													38	64	---	---	---	---					
GTF3C1	2975	broad.mit.edu	37	16	27475772	27475772	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:27475772delG	ENST00000356183.4	-	34	5756	c.5741delC	c.(5740-5742)cafs	p.P1914fs	GTF3C1_ENST00000561623.1_Frame_Shift_Del_p.P1914fs	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1914						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						TTCAAGAGCTGGGGGTGGAGA	0.652													88	169	---	---	---	---					
CD2BP2	10421	broad.mit.edu	37	16	30364763	30364763	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:30364763delG	ENST00000305596.3	-	5	909	c.734delC	c.(733-735)cafs	p.P246fs	CD2BP2_ENST00000569466.1_Frame_Shift_Del_p.P246fs	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	246					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						CAGGGAGGGTGGGGGTGTGGG	0.612													35	75	---	---	---	---					
LINC00922	0	broad.mit.edu	37	16	65397265	65397266	+	RNA	INS	-	-	A			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:65397265_65397266insA	ENST00000569736.1	-	0	486				RP11-256I9.3_ENST00000562656.1_lincRNA	NR_027755.1																						TAACTTCAGACAAAAAAATATA	0.436													11	3	---	---	---	---					
PDPR	55066	broad.mit.edu	37	16	70190614	70190614	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:70190614delG	ENST00000288050.4	+	19	3429	c.2472delG	c.(2470-2472)acfs	p.T824fs	PDPR_ENST00000398122.3_Frame_Shift_Del_p.T724fs|PDPR_ENST00000568530.1_Frame_Shift_Del_p.T824fs|RP11-296I10.3_ENST00000566989.1_RNA|PDPR_ENST00000542659.1_Frame_Shift_Del_p.T169fs|PDPR_ENST00000567046.1_Frame_Shift_Del_p.T182fs|PDPR_ENST00000562100.1_3'UTR	NM_017990.3	NP_060460.4	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory subunit	824					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		CTGAGGACACGGGGGAAGAGC	0.557													26	122	---	---	---	---					
AARS	16	broad.mit.edu	37	16	70288530	70288530	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:70288530delA	ENST00000261772.8	-	17	2537	c.2394delT	c.(2392-2394)ctfs	p.L798fs		NM_001605.2	NP_001596.2	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	798					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(3)|cervix(2)|endometrium(5)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	CTACCTCTCCAAGGTCAGCGA	0.547													21	43	---	---	---	---					
GSE1	23199	broad.mit.edu	37	16	85682261	85682261	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:85682261delC	ENST00000253458.7	+	3	506	c.330delC	c.(328-330)gtfs	p.V110fs	GSE1_ENST00000405402.2_Frame_Shift_Del_p.V6fs|GSE1_ENST00000393243.1_Frame_Shift_Del_p.V37fs	NM_014615.2	NP_055430.1			Gse1 coiled-coil protein																		CTATCATCGTCCCCCCTGGGG	0.677													78	104	---	---	---	---					
KLHDC4	54758	broad.mit.edu	37	16	87788830	87788830	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:87788830delG	ENST00000270583.5	-	4	397	c.339delC	c.(337-339)ccfs	p.P113fs	KLHDC4_ENST00000347925.5_Frame_Shift_Del_p.P113fs|KLHDC4_ENST00000353170.5_Frame_Shift_Del_p.P56fs	NM_017566.3	NP_060036.2	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	113										breast(2)|endometrium(3)|lung(10)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	21				BRCA - Breast invasive adenocarcinoma(80;0.0283)		GAGGTGGACTGGGGATGTCAA	0.512													33	48	---	---	---	---					
SPG7	6687	broad.mit.edu	37	16	89598886	89598886	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr16:89598886delG	ENST00000268704.2	+	9	1181	c.1166delG	c.(1165-1167)ctfs	p.R389fs	SPG7_ENST00000341316.2_Frame_Shift_Del_p.R389fs	NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	389					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		GGCGCTGCCCGTGTGCGGAGC	0.582													57	103	---	---	---	---					
CAMTA2	23125	broad.mit.edu	37	17	4875738	4875738	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:4875738delG	ENST00000361571.5	-	15	3005	c.2594delC	c.(2593-2595)ctfs	p.P865fs	CAMTA2_ENST00000358183.4_Frame_Shift_Del_p.P866fs|CAMTA2_ENST00000414043.3_Frame_Shift_Del_p.P889fs|CAMTA2_ENST00000381311.5_Frame_Shift_Del_p.P868fs|CAMTA2_ENST00000348066.3_Frame_Shift_Del_p.P866fs|CAMTA2_ENST00000572543.1_Frame_Shift_Del_p.P871fs	NM_001171168.1	NP_001164639.1	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	866					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						CAGAGGTGCAGGGGGGGGACT	0.612													20	23	---	---	---	---					
ELAC2	60528	broad.mit.edu	37	17	12897743	12897744	+	Splice_Site	DEL	TG	TG	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:12897743_12897744delTG	ENST00000338034.4	-	22	2345_2346	c.2108_splice	c.e22+1	p.HS702_splice	ELAC2_ENST00000426905.3_Splice_Site_p.HS662_splice|ELAC2_ENST00000395962.2_Splice_Site_p.HS683_splice	NM_018127.6|NM_173717.1	NP_060597.4|NP_776065.1	Q9BQ52	RNZ2_HUMAN	elaC ribonuclease Z 2	702					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|skin(1)	23						CTTTGCTACCTGTGTGTCTTTT	0.564													157	289	---	---	---	---					
RAI1	10743	broad.mit.edu	37	17	17698653	17698653	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:17698653delC	ENST00000353383.1	+	3	2860	c.2391delC	c.(2389-2391)gafs	p.D797fs	RAI1_ENST00000261641.6_Frame_Shift_Del_p.D797fs	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	797						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		AGGAGGAGGACCCCCCTGGGG	0.667													21	34	---	---	---	---					
RP11-160E2.17	0	broad.mit.edu	37	17	18988562	18988563	+	RNA	DEL	TT	TT	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:18988562_18988563delTT	ENST00000442355.2	+	0	272																											CTGATGTGTGTTTTTTTTTTTA	0.277													4	9	---	---	---	---					
NLK	51701	broad.mit.edu	37	17	26519194	26519195	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:26519194_26519195delCT	ENST00000407008.3	+	10	2202_2203	c.1484_1485delCT	c.(1483-1485)cfs	p.P495fs		NM_016231.4	NP_057315.3	Q9UBE8	NLK_HUMAN	nemo-like kinase	495					intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(1)	14	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		AACAGAGTGCCTCTCTGCATCA	0.376													10	12	---	---	---	---					
TAF15	8148	broad.mit.edu	37	17	34171886	34171886	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:34171886delG	ENST00000588240.1	+	15	1698	c.1583delG	c.(1582-1584)cgfs	p.R528fs	TAF15_ENST00000311979.3_Frame_Shift_Del_p.R525fs|TAF15_ENST00000592237.1_Frame_Shift_Del_p.G334fs	NM_003487.3|NM_139215.2	NP_003478.1|NP_631961.1	Q92804	RBP56_HUMAN	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	528	21 X approximate tandem repeats of D-R- [S,G](0,3)-G-G-Y-G-G.|Arg/Gly-rich.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	lung(1)|ovary(1)|skin(2)|stomach(1)	5		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		gACAGAAGCCGGGGGGGCTAT	0.612			T	"""TEC, CHN1, ZNF384"""	"""extraskeletal myxoid chondrosarcomas, ALL"""								44	63	---	---	---	---					
KRT222	125113	broad.mit.edu	37	17	38818272	38818272	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:38818272delT	ENST00000476049.1	-	2	162	c.121delA	c.(121-123)tgfs	p.M41fs	KRT222_ENST00000394052.3_Frame_Shift_Del_p.M41fs			Q8N1A0	KT222_HUMAN	keratin 222	41						intermediate filament	structural molecule activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(2)|skin(1)	15						TCTTTGTCCATTTTTTTGCTT	0.428													65	97	---	---	---	---					
HOXB1	3211	broad.mit.edu	37	17	46607839	46607839	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:46607839delG	ENST00000239174.6	-	1	520	c.428delC	c.(427-429)ctfs	p.P143fs	HOXB1_ENST00000577092.1_Frame_Shift_Del_p.P143fs	NM_002144.3	NP_002135.2	P14653	HXB1_HUMAN	homeobox B1	143						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GTTCCCATAAGGGGGATGCTG	0.617													27	53	---	---	---	---					
COIL	8161	broad.mit.edu	37	17	55028016	55028016	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:55028016delT	ENST00000240316.4	-	2	621	c.587delA	c.(586-588)agfs	p.K196fs		NM_004645.2	NP_004636.1	P38432	COIL_HUMAN	coilin	196	Lys-rich (basic).					Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					ATTCTTAGCCTTTTTTTTATA	0.393													48	79	---	---	---	---					
DNAH17	8632	broad.mit.edu	37	17	76425217	76425217	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr17:76425217delG	ENST00000389840.5	-	76	12496	c.12372delC	c.(12370-12372)ccfs	p.P4124fs	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Frame_Shift_Del_p.P4125fs					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AGTCCAGGTTGGGGGGGATCT	0.582													42	132	---	---	---	---					
EPG5	57724	broad.mit.edu	37	18	43459143	43459143	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:43459143delA	ENST00000282041.5	-	33	5738	c.5704delT	c.(5704-5706)atfs	p.Y1902fs	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	1902					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						CGAAGCTTATAAAAAAAGTCT	0.343													54	61	---	---	---	---					
RTTN	25914	broad.mit.edu	37	18	67697249	67697249	+	Splice_Site	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr18:67697249delT	ENST00000255674.6	-	42	6030	c.5745_splice	c.e42+1	p.K1915_splice	RTTN_ENST00000579986.1_5'UTR|RTTN_ENST00000454359.1_3'UTR	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	1915							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				GAATGTTACCTTTTTTTTCAA	0.398													57	70	---	---	---	---					
TICAM1	148022	broad.mit.edu	37	19	4816465	4816465	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:4816465delG	ENST00000248244.5	-	2	2154	c.1925delC	c.(1924-1926)cafs	p.P644fs		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	644	Pro-rich.|Sufficient to induce apoptosis.			Missing (in Ref. 6; AAO85488).	apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity	p.P643fs*>71(1)		NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GGAGGGCGGTGGGGGGGTGCC	0.731													20	24	---	---	---	---					
SAFB2	9667	broad.mit.edu	37	19	5587282	5587282	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:5587282delG	ENST00000252542.4	-	21	3098	c.2834delC	c.(2833-2835)cgfs	p.P945fs		NM_014649.2	NP_055464.1	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	945	Interacts with SAFB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding	p.P945fs*>9(1)		endometrium(3)|kidney(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		gtgggggtacggggggggatg	0.657													9	18	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9062393	9062394	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:9062393_9062394delTG	ENST00000397910.4	-	3	25255_25256	c.25052_25053delCA	c.(25051-25053)afs	p.T8351fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8353	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGTCACTGCTGTGTGTGTGGA	0.485													57	88	---	---	---	---					
ZNF433	163059	broad.mit.edu	37	19	12127235	12127235	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:12127235delT	ENST00000419886.2	-	5	633	c.342delA	c.(340-342)aafs	p.K114fs	CTD-2006C1.2_ENST00000406892.2_RNA|ZNF433_ENST00000344980.6_Frame_Shift_Del_p.K149fs|CTD-2006C1.2_ENST00000476474.1_RNA|CTD-2006C1.2_ENST00000495324.1_RNA			Q8N7K0	ZN433_HUMAN	zinc finger protein 433	149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(1)|prostate(1)|skin(1)	14						AGTTGAAAGGTTTTTTACAGT	0.368													61	89	---	---	---	---					
CPAMD8	27151	broad.mit.edu	37	19	17039883	17039884	+	Frame_Shift_Ins	INS	-	-	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:17039883_17039884insC	ENST00000443236.1	-	24	3184_3185	c.3153_3154insG	c.(3151-3156)ggatcafs	p.S1052fs		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1005						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity	p.H1052fs*30(1)		breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GTGTTCTGATGCCCCCCCAGGA	0.584													21	27	---	---	---	---					
ELL	8178	broad.mit.edu	37	19	18569071	18569073	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:18569071_18569073delCTT	ENST00000262809.4	-	6	882_884	c.811_813delAAG	c.(811-813)del	p.K271del		NM_006532.3	NP_006523.1	P55199	ELL_HUMAN	elongation factor RNA polymerase II	271					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(5)|prostate(1)	19				GBM - Glioblastoma multiforme(1328;7.81e-07)		CAGGCCAGTCCTTCTGCACATCC	0.601			T	MLL	AL								30	50	---	---	---	---					
WBP7	0	broad.mit.edu	37	19	36229400	36229400	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:36229400delC	ENST00000420124.1	+	37	8090	c.8090delC	c.(8089-8091)gcfs	p.A2697fs	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000222270.7_Frame_Shift_Del_p.A2697fs																							ATCGAGGATGCCAGCAACAAG	0.617													22	28	---	---	---	---					
PAK4	0	broad.mit.edu	37	19	39664268	39664269	+	Frame_Shift_Ins	INS	-	-	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:39664268_39664269insC	ENST00000599386.1	+	4	438_439	c.257_258insC	c.(256-258)accfs	p.T86fs	PAK4_ENST00000321944.4_Frame_Shift_Ins_p.T149fs|PAK4_ENST00000358301.3_Frame_Shift_Ins_p.T239fs|PAK4_ENST00000599470.1_Frame_Shift_Ins_p.T86fs|PAK4_ENST00000593690.1_Frame_Shift_Ins_p.T239fs|PAK4_ENST00000360442.3_Frame_Shift_Ins_p.T239fs|PAK4_ENST00000435673.2_Frame_Shift_Ins_p.T239fs	NM_001014835.1	NP_001014835.1	O96013	PAK4_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 4	239	Linker.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	13	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			GGCCTGGCCATCCCCCAGTCCT	0.703													19	17	---	---	---	---					
DMPK	1760	broad.mit.edu	37	19	46283185	46283185	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:46283185delG	ENST00000600757.1	-	1	820	c.133delC	c.(133-135)ttfs	p.L45fs	DMPK_ENST00000291270.4_Intron|DMPK_ENST00000458663.2_Intron|DMPK_ENST00000447742.2_Intron|DMPK_ENST00000354227.5_Intron|AC011530.4_ENST00000593999.1_Intron|DMPK_ENST00000343373.4_Frame_Shift_Del_p.L45fs			Q09013	DMPK_HUMAN	dystrophia myotonica-protein kinase	45					regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(5)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)|urinary_tract(2)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		CTGGAGACAAGGGGGAAAGCC	0.612													14	24	---	---	---	---					
ARHGAP35	2909	broad.mit.edu	37	19	47424741	47424741	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:47424741delT	ENST00000404338.3	+	1	2809	c.2809delT	c.(2809-2811)ttfs	p.F938fs		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	938					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										CTTTCACCCATTTTTTAAAGA	0.453													77	118	---	---	---	---					
RASIP1	54922	broad.mit.edu	37	19	49232773	49232773	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:49232773delC	ENST00000222145.4	-	5	1458	c.1254delG	c.(1252-1254)ggfs	p.G418fs		NM_017805.2	NP_060275.2	Q5U651	RAIN_HUMAN	Ras interacting protein 1	418					signal transduction	Golgi stack|perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	21		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GAGCCGGGGACCCCCCGCGGC	0.657													9	6	---	---	---	---					
IL4I1	259307	broad.mit.edu	37	19	50393104	50393104	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:50393104delC	ENST00000595948.1	-	10	2213	c.1593delG	c.(1591-1593)ggfs	p.G531fs	IL4I1_ENST00000391826.2_Frame_Shift_Del_p.G509fs|IL4I1_ENST00000341114.3_Frame_Shift_Del_p.G531fs	NM_001258018.1	NP_001244947.1	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1	509						lysosome	L-amino-acid oxidase activity			endometrium(3)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	16		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		CCGATGCAGGCCCCTTCCGGC	0.687													31	33	---	---	---	---					
SHANK1	50944	broad.mit.edu	37	19	51192558	51192559	+	Frame_Shift_Ins	INS	-	-	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:51192558_51192559insG	ENST00000391813.1	-	1	102_103	c.103_104insC	c.(103-105)tttfs	p.F35fs	SHANK1_ENST00000293441.1_Intron|SHANK1_ENST00000391814.1_Intron|SHANK1_ENST00000359082.3_Intron			Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1218					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GCAGGAGAAATGGGGGGGTGGT	0.589													17	47	---	---	---	---					
CTD-2245F17.3	0	broad.mit.edu	37	19	53703989	53703990	+	RNA	INS	-	-	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:53703989_53703990insC	ENST00000597550.1	+	0	232																											TTGTTCTGTTTCCCCCtttttt	0.470													3	5	---	---	---	---					
ZSCAN18	65982	broad.mit.edu	37	19	58596656	58596656	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr19:58596656delG	ENST00000240727.6	-	7	1328	c.929delC	c.(928-930)ctfs	p.P310fs	ZSCAN18_ENST00000421612.2_Frame_Shift_Del_p.P174fs|ZSCAN18_ENST00000600404.1_Frame_Shift_Del_p.P366fs|ZSCAN18_ENST00000601144.1_Frame_Shift_Del_p.P310fs	NM_023926.4	NP_076415.3	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	310					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P310fs*119(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGCGTCCCCAGGGGGCGCCTC	0.746													25	30	---	---	---	---					
TRIB3	57761	broad.mit.edu	37	20	368784	368784	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:368784delC	ENST00000217233.3	+	2	683	c.130delC	c.(130-132)ccfs	p.P45fs	TRIB3_ENST00000422053.2_Frame_Shift_Del_p.P72fs|TRIB3_ENST00000485293.1_3'UTR	NM_021158.3	NP_066981.2	Q96RU7	TRIB3_HUMAN	tribbles pseudokinase 3	45					apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|skin(1)	21		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		GCCCAGACTGCCCCCCTGCCT	0.627													15	229	---	---	---	---					
SOGA1	140710	broad.mit.edu	37	20	35444375	35444376	+	Frame_Shift_Ins	INS	-	-	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr20:35444375_35444376insC	ENST00000237536.4	-	5	1810_1811	c.1469_1470insG	c.(1468-1470)gccfs	p.A490fs	SOGA1_ENST00000456801.2_Frame_Shift_Ins_p.A93fs|SOGA1_ENST00000357779.3_Frame_Shift_Ins_p.A252fs|SOGA1_ENST00000279034.5_Frame_Shift_Ins_p.A252fs	NM_080627.2	NP_542194.2	O94964	K0889_HUMAN	suppressor of glucose, autophagy associated 1	252										endometrium(5)|kidney(1)|lung(21)|urinary_tract(1)	28						GTGCCTCAGGACCCCCACAGCC	0.668													17	35	---	---	---	---					
SCAF4	57466	broad.mit.edu	37	21	33068894	33068896	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr21:33068894_33068896delGGA	ENST00000286835.7	-	8	1327_1329	c.945_947delTCC	c.(943-948)cca>cc	p.PP315del	SCAF4_ENST00000434667.3_In_Frame_Del_p.PP300del|SCAF4_ENST00000399804.1_In_Frame_Del_p.PP315del	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	315	Poly-Pro.					nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						TGGTGCCTGTGGAGGAGGAGGAG	0.512													20	38	---	---	---	---					
MCM3AP	8888	broad.mit.edu	37	21	47662805	47662805	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr21:47662805delA	ENST00000397708.1	-	26	5591	c.5337delT	c.(5335-5337)ttfs	p.F1779fs	MCM3AP-AS1_ENST00000455567.1_RNA|MCM3AP_ENST00000467026.1_5'UTR|MCM3AP-AS1_ENST00000414659.1_RNA|MCM3AP-AS1_ENST00000432735.1_RNA|MCM3AP-AS1_ENST00000444998.1_RNA|MCM3AP_ENST00000291688.1_Frame_Shift_Del_p.F1779fs|MCM3AP-AS1_ENST00000588753.1_RNA|MCM3AP-AS1_ENST00000591223.1_RNA|MCM3AP-AS1_ENST00000590829.1_RNA|MCM3AP-AS1_ENST00000421927.1_RNA			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1779					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding	p.K1780fs*5(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					AATCGTTTTTAAAAAAATACA	0.433													45	75	---	---	---	---					
TUBA8	51807	broad.mit.edu	37	22	18609160	18609161	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:18609160_18609161delCA	ENST00000330423.3	+	4	488_489	c.415_416delCA	c.(415-417)cfs	p.H139fs	TUBA8_ENST00000316027.6_Frame_Shift_Del_p.H73fs	NM_018943.2	NP_061816.1	Q9NY65	TBA8_HUMAN	tubulin, alpha 8	139					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	14						CCTGATTTTCCACAGTTTTGGT	0.520													65	135	---	---	---	---					
ZDHHC8	29801	broad.mit.edu	37	22	20130522	20130522	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:20130522delC	ENST00000334554.7	+	10	1510	c.1369delC	c.(1369-1371)ccfs	p.P458fs	ZDHHC8_ENST00000405930.3_Frame_Shift_Del_p.P458fs|ZDHHC8_ENST00000320602.7_Frame_Shift_Del_p.P366fs	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	458						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					TGAGGGGGGGCCCCCCACGCC	0.687													31	26	---	---	---	---					
THAP7	80764	broad.mit.edu	37	22	21354970	21354970	+	Frame_Shift_Del	DEL	C	C	-	rs426938	byFrequency	TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:21354970delC	ENST00000215742.4	-	3	517	c.343delG	c.(343-345)ctfs	p.A115fs	THAP7_ENST00000399133.2_Frame_Shift_Del_p.A115fs	NM_030573.2	NP_085050.2	Q9BT49	THAP7_HUMAN	THAP domain containing 7	115			A -> P (in dbSNP:rs426938).		negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck	C2H2 zinc finger domain binding|DNA binding|metal ion binding|protein N-terminus binding	p.A115P(1)		cervix(1)|lung(2)|prostate(3)|skin(1)|stomach(1)	8	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CTGACTTCAGCGGGGCCAGGT	0.602													85	120	---	---	---	---					
CES5AP1	0	broad.mit.edu	37	22	23712779	23712779	+	RNA	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:23712779delA	ENST00000415114.1	-	0	606																											CTTAGAGGGGAAAAAAAACCC	0.458													2	4	---	---	---	---					
GGT5	2687	broad.mit.edu	37	22	24627387	24627387	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:24627387delC	ENST00000327365.4	-	6	1282	c.866delG	c.(865-867)gtfs	p.G289fs	GGT5_ENST00000418439.2_Frame_Shift_Del_p.G212fs|GGT5_ENST00000263112.7_Frame_Shift_Del_p.G257fs|GGT5_ENST00000398292.3_Frame_Shift_Del_p.G289fs	NM_001099781.1|NM_004121.2	NP_001093251.1|NP_004112.2	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5	289					glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(3)|skin(3)	28						GAGAATGGCACCCCCTGCAGG	0.677													2	4	---	---	---	---					
EIF4ENIF1	56478	broad.mit.edu	37	22	31838994	31838994	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:31838994delT	ENST00000397525.1	-	16	2383	c.2160delA	c.(2158-2160)aafs	p.K720fs	EIF4ENIF1_ENST00000344710.5_Frame_Shift_Del_p.K546fs|EIF4ENIF1_ENST00000397523.1_Frame_Shift_Del_p.K696fs|EIF4ENIF1_ENST00000330125.5_Frame_Shift_Del_p.K720fs|EIF4ENIF1_ENST00000382180.2_Frame_Shift_Del_p.K375fs	NM_001164501.1	NP_001157973.1	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E nuclear import factor 1	720						nucleus	protein binding|protein transporter activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						CAAGAGCTGCTTTTCCAGATG	0.463													74	82	---	---	---	---					
C22orf24	25775	broad.mit.edu	37	22	32330115	32330117	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:32330115_32330117delAGA	ENST00000248984.3	-	3	636_638	c.470_472delTCT	c.(469-474)tcc>t	p.FS157del	C22orf24_ENST00000543051.1_In_Frame_Del_p.FS224del|C22orf24_ENST00000486651.1_5'UTR	NM_015372.1	NP_056187.1	Q9Y442	CV024_HUMAN	chromosome 22 open reading frame 24	157						integral to membrane				central_nervous_system(1)|urinary_tract(1)	2						CAGGACTCGGAGAAGATGTTGCT	0.571													13	21	---	---	---	---					
NPTXR	23467	broad.mit.edu	37	22	39222592	39222592	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:39222592delG	ENST00000333039.2	-	3	1134	c.1011delC	c.(1009-1011)ccfs	p.P337fs		NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	337	Pentaxin.					integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					AGTAGGAGAAGGGGGTGCCCT	0.652													68	107	---	---	---	---					
TCF20	6942	broad.mit.edu	37	22	42606139	42606139	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:42606139delA	ENST00000359486.3	-	1	5309	c.5173delT	c.(5173-5175)atfs	p.Y1725fs	TCF20_ENST00000335626.4_Frame_Shift_Del_p.Y1725fs|TCF20_ENST00000404876.1_Frame_Shift_Del_p.Y26fs	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1725					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						TCTTGGGGATAAAAAGGTCCA	0.502													59	78	---	---	---	---					
TTLL8	164714	broad.mit.edu	37	22	50488585	50488585	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:50488585delA	ENST00000266182.6	-	2	142	c.143delT	c.(142-144)tgfs	p.L48fs	TTLL8_ENST00000440475.1_Frame_Shift_Del_p.L48fs|TTLL8_ENST00000477219.1_5'UTR					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		GACCTTGGGCAAAAAGTGGAA	0.572													20	20	---	---	---	---					
ARSA	410	broad.mit.edu	37	22	51065756	51065757	+	Frame_Shift_Ins	INS	-	-	C	rs74315455		TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:51065756_51065757insC	ENST00000547307.1	-	2	701_702	c.296_297insG	c.(295-297)gctfs	p.A99fs	ARSA_ENST00000395619.3_Frame_Shift_Ins_p.A101fs|ARSA_ENST00000216124.5_Frame_Shift_Ins_p.A101fs|ARSA_ENST00000356098.5_Frame_Shift_Ins_p.A101fs|ARSA_ENST00000453344.2_Frame_Shift_Ins_p.A15fs|ARSA_ENST00000547805.1_Frame_Shift_Ins_p.A99fs|ARSA_ENST00000395621.3_Frame_Shift_Ins_p.A101fs			P15289	ARSA_HUMAN	arylsulfatase A	99			G -> D (in MLD; adult type).|G -> V (in MLD; late-infantile form).			lysosome	arylsulfatase activity|calcium ion binding|cerebroside-sulfatase activity			endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|skin(1)	9		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)	Micafungin(DB01141)	CCAGGGGCAGGCCCCCCCGGGA	0.718													8	9	---	---	---	---					
SHANK3	85358	broad.mit.edu	37	22	51159932	51159933	+	Frame_Shift_Ins	INS	-	-	G			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:51159932_51159933insG	ENST00000414786.2	+	21	3856_3857	c.3629_3630insG	c.(3628-3630)cggfs	p.R1210fs	SHANK3_ENST00000262795.3_Frame_Shift_Ins_p.R1240fs|SHANK3_ENST00000445220.2_Frame_Shift_Ins_p.R1226fs			F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1240										central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)	8		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		CCCAGCAGGCTGGGGGGGGCCG	0.718													8	8	---	---	---	---					
ACR	49	broad.mit.edu	37	22	51178329	51178330	+	Frame_Shift_Ins	INS	-	-	C			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chr22:51178329_51178330insC	ENST00000216139.5	+	3	529_530	c.489_490insC	c.(487-492)ctcccafs	p.LP163fs	ACR_ENST00000529621.1_Frame_Shift_Ins_p.LP163fs	NM_001097.2	NP_001088.2	P10323	ACRO_HUMAN	acrosin	163	Peptidase S1.				acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		CGGGCTGCCTGCCCCACTTTAA	0.579													68	93	---	---	---	---					
SLC25A6	293	broad.mit.edu	37	X	1508427	1508427	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:1508427delC	ENST00000381401.5	-	2	1019	c.305delG	c.(304-306)gcfs	p.G102fs	SLC25A6_ENST00000475167.1_5'UTR	NM_001636.3	NP_001627.2	P12236	ADT3_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	102					active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|upper_aerodigestive_tract(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	CTTGTCCACGCCCCCCAGGAA	0.607													101	189	---	---	---	---					
ARSE	415	broad.mit.edu	37	X	2854881	2854883	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:2854881_2854883delAGA	ENST00000545496.1	-	11	1677_1679	c.1386_1388delTCT	c.(1384-1389)ctg>ct	p.LL462del	ARSE_ENST00000540563.1_In_Frame_Del_p.LL392del|ARSE_ENST00000381134.3_In_Frame_Del_p.LL437del			P51690	ARSE_HUMAN	arylsulfatase E (chondrodysplasia punctata 1)	437					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GAGCAAGGGCAGAAGGTCTTGGC	0.562													20	25	---	---	---	---					
RBM10	8241	broad.mit.edu	37	X	47030467	47030469	+	In_Frame_Del	DEL	GGC	GGC	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:47030467_47030469delGGC	ENST00000377604.3	+	4	984_986	c.242_244delGGC	c.(241-246)agg>a	p.RR83del	RBM10_ENST00000329236.7_Intron|RBM10_ENST00000468791.1_3'UTR|RBM10_ENST00000345781.6_Intron	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	83	Poly-Arg.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding	p.R85delR(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						ACTCAGCGTAGGCGGCGGCGGCG	0.680													26	40	---	---	---	---					
GATA1	2623	broad.mit.edu	37	X	48652397	48652397	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:48652397delC	ENST00000376670.3	+	6	1179	c.1068delC	c.(1066-1068)ggfs	p.G356fs	GATA1_ENST00000376665.3_Intron	NM_002049.3	NP_002040.1	P15976	GATA1_HUMAN	GATA binding protein 1 (globin transcription factor 1)	356					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(259)|large_intestine(8)|lung(9)|prostate(1)	283						TGACACTGGGCCCCCCAGGTA	0.647			"""Mis, F"""		megakaryoblastic leukemia of Downs Syndrome								7	15	---	---	---	---					
TSPYL2	64061	broad.mit.edu	37	X	53111865	53111865	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:53111865delG	ENST00000375442.4	+	1	317	c.185delG	c.(184-186)agfs	p.R62fs		NM_022117.3	NP_071400.1	Q9H2G4	TSYL2_HUMAN	TSPY-like 2	62	Pro-rich.				cell cycle|chromatin modification|negative regulation of cell cycle|negative regulation of cell growth|negative regulation of DNA replication|nucleosome assembly|regulation of protein kinase activity|regulation of signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|rDNA binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)	19						GCCGATATGAGGGGGGTGGGA	0.726													6	11	---	---	---	---					
TSIX	0	broad.mit.edu	37	X	73045718	73045718	+	RNA	DEL	A	A	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:73045718delA	ENST00000604411.1	+	0	33679				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						AAACAGGAAGAAAAAAATCAA	0.368													16	31	---	---	---	---					
FRMD7	90167	broad.mit.edu	37	X	131212901	131212903	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-N7-A4Y0-01A-12D-A28R-08	TCGA-N7-A4Y0-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffa10f6e-3a4a-42c5-af29-409d32d734f1	14126835-cedc-4c9b-bbb9-8dc9cc5be73e	g.chrX:131212901_131212903delTCC	ENST00000298542.4	-	12	1317_1319	c.1142_1144delGGA	c.(1141-1146)aat>a	p.RN381del	FRMD7_ENST00000370879.1_In_Frame_Del_p.RN261del|FRMD7_ENST00000464296.1_In_Frame_Del_p.RN366del	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	381					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					aatgcagaattcctcctcctact	0.498													12	298	---	---	---	---					
