Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TMEM201	199953	broad.mit.edu	37	1	9661177	9661177	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:9661177C>T	ENST00000340305.5	+	5	630	c.621C>T	c.(619-621)gcC>gcT	p.A207A	TMEM201_ENST00000377376.4_Silent_p.A207A|TMEM201_ENST00000340381.6_Silent_p.A207A	NM_001010866.3	NP_001010866.1	Q5SNT2	TM201_HUMAN	transmembrane protein 201	207						integral to membrane|nuclear inner membrane				lung(3)|upper_aerodigestive_tract(1)	4	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)		TCTCCTCCGCCGTGAAGTCCC	0.652000													37	121					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98581955	98581955	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:98581955G>A	ENST00000359863.4	+	60	9483	c.9274G>A	c.(9274-9276)Gtc>Atc	p.V3092I	TRRAP_ENST00000446306.3_Missense_Mutation_p.V3063I|TRRAP_ENST00000355540.3_Missense_Mutation_p.V3063I	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3092	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GCTGGCAGGCGTCATGGGCAA	0.498000													54	126					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121957767	121957767	+	Silent	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr4:121957767G>A	ENST00000379692.4	-	4	1885	c.1359C>T	c.(1357-1359)atC>atT	p.I453I		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	453	Fibronectin type-III 2.									breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						CAAAGGCTTTGATTCTTGTGT	0.448000													64	61					0	0	1	0	0
HTR3E	285242	broad.mit.edu	37	3	183818194	183818194	+	Missense_Mutation	SNP	C	C	T	rs142990158	byFrequency	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:183818194C>T	ENST00000335304.2	+	1	228	c.34C>T	c.(34-36)Cgc>Tgc	p.R12C	HTR3E_ENST00000440596.2_Missense_Mutation_p.R12C|HTR3E_ENST00000415389.2_Intron|HTR3E-AS1_ENST00000431427.1_RNA|HTR3E_ENST00000436361.2_Missense_Mutation_p.R12C|HTR3E_ENST00000425359.2_Intron	NM_182589.2|NM_198314.2	NP_872395.2|NP_938056.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	0						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GGCGACCCCACGCCCTGCCTT	0.478000													50	58					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577534	7577534	+	Missense_Mutation	SNP	C	C	A	rs28934571		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:7577534C>A	ENST00000420246.2	-	7	879	c.747G>T	c.(745-747)agG>agT	p.R249S	TP53_ENST00000455263.2_Missense_Mutation_p.R249S|TP53_ENST00000413465.2_Missense_Mutation_p.R249S|TP53_ENST00000445888.2_Missense_Mutation_p.R249S|TP53_ENST00000269305.4_Missense_Mutation_p.R249S|TP53_ENST00000359597.4_Missense_Mutation_p.R249S	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	249	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> I (in a sporadic cancer; somatic mutation).|R -> K (in sporadic cancers; somatic mutation).|R -> M (in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in sporadic cancers; somatic mutation; dbSNP:rs28934571).|R -> T (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|RP -> SS (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R249S(348)|p.0?(8)|p.R249R(5)|p.?(5)|p.M246_P250delMNRRP(2)|p.R248_P250delRRP(1)|p.R249_P250delRP(1)|p.R249_P250insR(1)|p.R249_P250>SS(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*14(1)|p.R249_T256delRPILTIIT(1)|p.P250fs*14(1)|p.R249_I251delRPI(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGAGGATGGGCCTCCGGTTCA	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	1					7.33628e-21	8.0564e-21	1	1	0
ATP5H	10476	broad.mit.edu	37	17	73036197	73036197	+	Missense_Mutation	SNP	T	T	C			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:73036197T>C	ENST00000301587.4	-	4	328	c.281A>G	c.(280-282)gAa>gGa	p.E94G	KCTD2_ENST00000581589.1_Intron|ATP5H_ENST00000344546.4_Intron|KCTD2_ENST00000584767.1_Intron	NM_006356.2	NP_006347.1	O75947	ATP5H_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d	94					ATP catabolic process|respiratory electron transport chain	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity			lung(1)|skin(1)	2	all_lung(278;0.226)					ATCTTCTTTTTCTTCGGCATC	0.408000													124	80					0	0	1	0	0
PTEN	5728	broad.mit.edu	37	10	89717672	89717672	+	Nonsense_Mutation	SNP	C	C	T	rs121909219		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr10:89717672C>T	ENST00000371953.3	+	7	2054	c.697C>T	c.(697-699)Cga>Tga	p.R233*	PTEN_ENST00000472832.1_3'UTR	NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	233	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R233*(77)|p.0?(37)|p.R55fs*1(5)|p.R233fs*10(3)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.?(1)|p.R233fs*12(1)|p.R233fs*20(1)|p.R233fs*25(1)|p.R233fs*23(1)|p.R233R(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGGACCCACACGACGGGAAGA	0.423000	R233*(HEC59_ENDOMETRIUM)|R233*(JHUEM1_ENDOMETRIUM)|R233*(NCIH1155_LUNG)|R233*(SF295_CENTRAL_NERVOUS_SYSTEM)|R233*(SW1783_CENTRAL_NERVOUS_SYSTEM)	31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			40	1					0	0	1	0	0
PRKD2	25865	broad.mit.edu	37	19	47207822	47207822	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:47207822G>A	ENST00000433867.1	-	5	1073	c.596C>T	c.(595-597)aCg>aTg	p.T199M	PRKD2_ENST00000595515.1_Missense_Mutation_p.T199M|PRKD2_ENST00000600194.1_Missense_Mutation_p.T42M|PRKD2_ENST00000601806.1_Missense_Mutation_p.T42M|PRKD2_ENST00000291281.4_Missense_Mutation_p.T199M	NM_001079880.1|NM_001079881.1|NM_016457.4	NP_001073349.1|NP_001073350.1|NP_057541.2	Q9BZL6	KPCD2_HUMAN	protein kinase D2	199					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	41		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		GGCCAGAGACGTGGATGACAG	0.667000											OREG0025578	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	79					0	0	1	0	0
FGB	2244	broad.mit.edu	37	4	155487137	155487137	+	Missense_Mutation	SNP	G	G	A	rs121909620		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr4:155487137G>A	ENST00000302068.4	+	2	355	c.292G>A	c.(292-294)Gct>Act	p.A98T	FGB_ENST00000509493.1_Intron|FGB_ENST00000502545.1_3'UTR	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain	98			A -> T (in Naples and Milano-2; associated with defective thrombin binding and thrombophilia).|Missing (in New York-1).		platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	CTGTCTTCACGCTGACCCAGA	0.537000													26	25					0	0	1	0	0
FAM5C	0	broad.mit.edu	37	1	190067975	190067975	+	Silent	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:190067975G>A	ENST00000367462.3	-	8	1705	c.1474C>T	c.(1474-1476)Ctg>Ttg	p.L492L	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Silent_p.L390L	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		492						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					AGATCTTGCAGGTCAGTTTCA	0.512000													29	136					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23891485	23891485	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:23891485C>T	ENST00000355349.3	-	25	3311	c.3149G>A	c.(3148-3150)cGa>cAa	p.R1050Q		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1050					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CCGCTTCGCTCGCTCCAGGTC	0.577000													25	23					0	0	1	0	0
NCF2	4688	broad.mit.edu	37	1	183532665	183532665	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:183532665G>A	ENST00000413720.1	-	11	1221	c.947C>T	c.(946-948)aCg>aTg	p.T316M	NCF2_ENST00000367535.3_Missense_Mutation_p.T361M|NCF2_ENST00000469280.1_5'UTR|NCF2_ENST00000418089.1_Missense_Mutation_p.T280M|NCF2_ENST00000367536.1_Missense_Mutation_p.T361M	NM_001190794.1	NP_001177723.1	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	361					cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30						CATGACTACCGTGTACTTGTA	0.547000													69	85					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17292083	17292083	+	Silent	SNP	G	G	A	rs149300797		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:17292083G>A	ENST00000261381.6	-	5	1359	c.1275C>T	c.(1273-1275)gcC>gcT	p.A425A		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	425					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TGGGGTAGTCGGCCGCACTCA	0.622000													11	66					0	0	1	0	0
BCAT2	587	broad.mit.edu	37	19	49303509	49303509	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:49303509G>A	ENST00000402551.1	-	5	846	c.226C>T	c.(226-228)Cgc>Tgc	p.R76C	BCAT2_ENST00000545387.2_Missense_Mutation_p.R24C|BCAT2_ENST00000598162.1_Missense_Mutation_p.R116C|BCAT2_ENST00000597011.1_Missense_Mutation_p.R76C|BCAT2_ENST00000316273.6_Missense_Mutation_p.R116C|BCAT2_ENST00000599246.1_Missense_Mutation_p.R24C			O15382	BCAT2_HUMAN	branched chain amino-acid transaminase 2, mitochondrial	116						mitochondrial matrix	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	12		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.000366)|Epithelial(262;0.0195)|GBM - Glioblastoma multiforme(486;0.0224)	L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|Pyridoxal Phosphate(DB00114)	CGGAAGAGGCGCACCTGCTGG	0.657000													19	99					0	0	1	0	0
COPB1	1315	broad.mit.edu	37	11	14481798	14481798	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr11:14481798G>A	ENST00000249923.3	-	20	2902	c.2602C>T	c.(2602-2604)Cac>Tac	p.H868Y	COPB1_ENST00000439561.2_Missense_Mutation_p.H868Y	NM_016451.4	NP_057535.1	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	868					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						TTTAATATGTGCTGTAAGTAG	0.358000													14	0					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													4	35					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107417136	107417136	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:107417136C>T	ENST00000340010.5	-	14	1714	c.1530G>A	c.(1528-1530)acG>acA	p.T510T	SLC26A3_ENST00000422236.2_Silent_p.T475T	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	510					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TATTAGCCAGCGTGCTGCATT	0.333000													5	71					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23530753	23530753	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:23530753G>A	ENST00000262710.1	-	17	3679	c.3352C>T	c.(3352-3354)Cac>Tac	p.H1118Y	ACIN1_ENST00000397341.3_Missense_Mutation_p.H360Y|ACIN1_ENST00000605057.1_Missense_Mutation_p.H1060Y|ACIN1_ENST00000457657.1_Missense_Mutation_p.H1078Y|ACIN1_ENST00000557515.1_Missense_Mutation_p.H359Y|ACIN1_ENST00000338631.6_Missense_Mutation_p.H391Y|ACIN1_ENST00000357481.2_Missense_Mutation_p.H360Y|ACIN1_ENST00000555053.1_Missense_Mutation_p.H1105Y	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1118	Pro-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GGTGGGGGGTGCAGGGGCCGT	0.662000													6	6					0	0	1	0	0
DIEXF	27042	broad.mit.edu	37	1	210014237	210014237	+	Missense_Mutation	SNP	C	C	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:210014237C>A	ENST00000491415.2	+	8	1379	c.1322C>A	c.(1321-1323)cCg>cAg	p.P441Q		NM_014388.6	NP_055203.4	Q68CQ4	DIEXF_HUMAN	digestive organ expansion factor homolog (zebrafish)	441					multicellular organismal development	nucleus				breast(6)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(15)|large_intestine(7)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(2)	53						CTCTATGCCCCGTTTTACTCC	0.468000													36	40					9.8876e-21	1.0792e-20	1	1	0
INSRR	3645	broad.mit.edu	37	1	156823762	156823762	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:156823762C>T	ENST00000368195.3	-	2	815	c.419G>A	c.(418-420)cGt>cAt	p.R140H	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	140					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTTCTCCACACGCACAGCCCC	0.627000													19	22					0	0	1	0	0
PTBP2	58155	broad.mit.edu	37	1	97217025	97217025	+	Silent	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:97217025G>A	ENST00000236228.6	+	3	166	c.84G>A	c.(82-84)ccG>ccA	p.P28P	PTBP2_ENST00000482253.1_Intron|PTBP2_ENST00000426398.2_Silent_p.P28P|PTBP2_ENST00000394184.3_Silent_p.P39P|PTBP2_ENST00000541987.1_5'UTR|PTBP2_ENST00000370198.1_Silent_p.P28P|PTBP2_ENST00000370197.1_Silent_p.P28P	NM_021190.2	NP_067013.1	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	28							nucleotide binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|skin(1)	26		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		TCAGTAGTCCGAACTCTAATA	0.348000													75	76					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31040264	31040264	+	Silent	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:31040264G>A	ENST00000355537.3	+	4	3885	c.3738G>A	c.(3736-3738)gcG>gcA	p.A1246A		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.A1246A(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					ACCCCTTGGCGGGCCTGCCAA	0.632000													36	20					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1582969	1582969	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:1582969G>A	ENST00000572621.1	-	8	1488	c.1223C>T	c.(1222-1224)cCg>cTg	p.P408L	PRPF8_ENST00000304992.6_Missense_Mutation_p.P408L			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	408						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GAAGGGCCGCGGGGCCCAGAG	0.572000													97	5					0	0	1	0	0
KYNU	8942	broad.mit.edu	37	2	143718291	143718291	+	Silent	SNP	T	T	C			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:143718291T>C	ENST00000264170.4	+	8	939	c.681T>C	c.(679-681)acT>acC	p.T227T	KYNU_ENST00000409512.1_Silent_p.T227T|KYNU_ENST00000375773.2_Silent_p.T227T	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase	227					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	ATTTTTACACTGGACAGCACT	0.428000													14	56					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91714219	91714219	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:91714219G>A	ENST00000359028.2	+	35	9034	c.8809G>A	c.(8809-8811)Gaa>Aaa	p.E2937K	AKAP9_ENST00000358100.2_Intron|AKAP9_ENST00000356239.3_Missense_Mutation_p.E2933K			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2937					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGAAGAAAGTGAAAGTGCAAC	0.368000			T	BRAF	papillary thyroid								51	106					0	0	1	0	0
CYP1B1	1545	broad.mit.edu	37	2	38301893	38301893	+	Silent	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:38301893G>A	ENST00000260630.3	-	2	1040	c.639C>T	c.(637-639)cgC>cgT	p.R213R	CYP1B1_ENST00000494864.1_Intron|CYP1B1_ENST00000407341.1_Silent_p.R213R	NM_000104.3	NP_000095.2	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B, polypeptide 1	213					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	13		all_hematologic(82;0.21)			Estrone(DB00655)	CGTGGCTGTAGCGGCAGCCGA	0.701000													4	14					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	10981913	10981913	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:10981913G>A	ENST00000304623.8	-	21	3578	c.3389C>T	c.(3388-3390)gCg>gTg	p.A1130V	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Missense_Mutation_p.A793V|CTNND2_ENST00000511377.1_Missense_Mutation_p.A1039V|CTNND2_ENST00000359640.2_Missense_Mutation_p.A1072V|CTNND2_ENST00000458100.2_Missense_Mutation_p.A697V	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1130					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TTCAGCGGGCGCACCATAAGA	0.343000													21	57					0	0	1	0	0
MALSU1	115416	broad.mit.edu	37	7	23347508	23347508	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:23347508C>T	ENST00000466681.1	+	3	610	c.457C>T	c.(457-459)Cgt>Tgt	p.R153C		NM_138446.1	NP_612455.1	Q96EH3	CG030_HUMAN	mitochondrial assembly of ribosomal large subunit 1	153						mitochondrion											GAAATGTAAACGTGACCCTCA	0.428000													16	111					0	0	1	0	0
FANCC	2176	broad.mit.edu	37	9	97912337	97912337	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr9:97912337C>T	ENST00000289081.3	-	7	808	c.554G>A	c.(553-555)cGa>cAa	p.R185Q	FANCC_ENST00000375305.1_Missense_Mutation_p.R185Q	NM_000136.2	NP_000127.2	Q00597	FANCC_HUMAN	Fanconi anemia, complementation group C	185					protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)|skin(1)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(62;0.138)				GACACAAACTCGTGACAGGGA	0.473000			"""D, Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				9	8					0	0	1	0	0
HAGHL	84264	broad.mit.edu	37	16	778930	778930	+	Missense_Mutation	SNP	G	G	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:778930G>T	ENST00000341413.4	+	7	916	c.635G>T	c.(634-636)gGg>gTg	p.G212V	HAGHL_ENST00000564537.1_3'UTR|HAGHL_ENST00000549114.1_3'UTR|HAGHL_ENST00000564545.1_3'UTR|HAGHL_ENST00000561546.1_Intron|HAGHL_ENST00000389703.3_Intron			Q6PII5	HAGHL_HUMAN	hydroxyacylglutathione hydrolase-like	212							hydrolase activity|metal ion binding			lung(3)	3		Hepatocellular(780;0.00335)				AAGAGGGTGGGGGGGGAGGGA	0.652000													4	2					0.000602214	0.000615979	1	1	0
PAPPA2	60676	broad.mit.edu	37	1	176709279	176709279	+	Silent	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:176709279G>A	ENST00000367662.3	+	14	5262	c.4098G>A	c.(4096-4098)tcG>tcA	p.S1366S		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1366					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.S1366S(1)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TTGGTCTTTCGGCTCCCAGTA	0.507000													33	32					0	0	1	0	0
PCDHB5	0	broad.mit.edu	37	5	140515250	140515250	+	Missense_Mutation	SNP	T	T	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:140515250T>A	ENST00000231134.5	+	1	451	c.234T>A	c.(232-234)gaT>gaA	p.D78E		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		78	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCAGCTTGATATAAAGACCG	0.502000													37	59					0	0	1	0	0
TMF1	7110	broad.mit.edu	37	3	69093748	69093748	+	Splice_Site	SNP	T	T	C			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:69093748T>C	ENST00000543976.1	-	3	1603		c.e3-2		CTD-2013N24.2_ENST00000596523.1_RNA|CTD-2013N24.2_ENST00000597950.1_RNA|CTD-2013N24.2_ENST00000598783.1_RNA|CTD-2013N24.2_ENST00000595925.1_RNA|TMF1_ENST00000398559.2_Splice_Site|CTD-2013N24.2_ENST00000596274.1_RNA|CTD-2013N24.2_ENST00000482368.2_RNA|CTD-2013N24.2_ENST00000596732.1_RNA|CTD-2013N24.2_ENST00000601735.1_RNA	NM_007114.2	NP_009045.2	P82094	TMF1_HUMAN	TATA element modulatory factor 1						regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		TTCAACTGTCTGGATAAGGCG	0.348000													6	19					0	0	1	0	0
PCDHA6	0	broad.mit.edu	37	5	140209479	140209479	+	Silent	SNP	A	A	G			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:140209479A>G	ENST00000529310.1	+	1	1917	c.1803A>G	c.(1801-1803)tcA>tcG	p.S601S	PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCCGACTCAGGCTACAACG	0.662000													5	215					0	0	1	0	0
RASEF	158158	broad.mit.edu	37	9	85615415	85615415	+	Missense_Mutation	SNP	T	T	C			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr9:85615415T>C	ENST00000376447.3	-	11	1768	c.1508A>G	c.(1507-1509)cAa>cGa	p.Q503R		NM_152573.2	NP_689786.2	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	503					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(4)|liver(1)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						AACAGACCCTTGGGGCTTCCA	0.443000													4	22					0	0	1	0	0
TFAM	7019	broad.mit.edu	37	10	60154714	60154714	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr10:60154714C>T	ENST00000487519.1	+	7	1147	c.621C>T	c.(619-621)gaC>gaT	p.D207D	TFAM_ENST00000373899.3_3'UTR|TFAM_ENST00000373895.3_Silent_p.D175D	NM_003201.1	NP_003192.1	Q00059	TFAM_HUMAN	transcription factor A, mitochondrial	207					DNA-dependent DNA replication|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase I promoter|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	mitochondrial light strand promoter sense binding|protein binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7						CTAAAGAGGACGAAACTCGTT	0.289000													3	1					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1083268	1083268	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr11:1083268G>A	ENST00000441003.2	+	16	2195	c.2168G>A	c.(2167-2169)cGc>cAc	p.R723H	MUC2_ENST00000359061.5_Missense_Mutation_p.R723H	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	723						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	TGTTACCACCGCGGTCTCTAC	0.682000													6	11					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158923254	158923254	+	Silent	SNP	T	T	C			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr6:158923254T>C	ENST00000367097.3	+	13	3916	c.2559T>C	c.(2557-2559)ccT>ccC	p.P853P	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	853					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CCCCGCCCCCTCTGCCGCCCC	0.652000													3	8					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135000063	135000063	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr10:135000063G>A	ENST00000304613.3	+	6	1232	c.1211G>A	c.(1210-1212)gGg>gAg	p.G404E	KNDC1_ENST00000368572.2_Missense_Mutation_p.G404E|KNDC1_ENST00000368571.2_Missense_Mutation_p.G339E			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	404					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CCCAGCCAGGGGCCAGCAGAG	0.662000													38	2					0	0	1	0	0
CD14	929	broad.mit.edu	37	5	140011859	140011859	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:140011859G>A	ENST00000302014.6	-	2	1339	c.710C>T	c.(709-711)cCc>cTc	p.P237L	CD14_ENST00000401743.2_Missense_Mutation_p.P237L	NM_000591.3	NP_000582.1	P08571	CD14_HUMAN	CD14 molecule	237					apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity			endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGCCTGTGGGCGTCTCCAT	0.657000													22	76					0	0	1	0	0
PAPD7	11044	broad.mit.edu	37	5	6742670	6742670	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:6742670C>T	ENST00000230859.6	+	5	455	c.326C>T	c.(325-327)aCg>aTg	p.T109M		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	109					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						AACATGGAGACGGGCGTCCGG	0.468000													26	22					0	0	1	0	0
DYNAP	284254	broad.mit.edu	37	18	52265364	52265364	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr18:52265364C>T	ENST00000321600.1	+	3	667	c.621C>T	c.(619-621)acC>acT	p.T207T	DYNAP_ENST00000585973.1_Silent_p.T155T	NM_173629.1	NP_775900.1			dynactin associated protein																		TTGCACCTACCGATCATTTAT	0.428000													35	44					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61981956	61981956	+	Silent	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr20:61981956G>A	ENST00000370263.4	-	5	1028	c.807C>T	c.(805-807)tcC>tcT	p.S269S	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	269					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CGCCACACTCGGAGGGCAGGT	0.602000													20	83					0	0	1	0	0
TYMS	7298	broad.mit.edu	37	18	672902	672902	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr18:672902C>T	ENST00000323274.10	+	7	986	c.847C>T	c.(847-849)Cga>Tga	p.R283*	TYMS_ENST00000323250.5_Nonsense_Mutation_p.R200*|TYMS_ENST00000323224.7_Nonsense_Mutation_p.R249*|ENOSF1_ENST00000383578.3_3'UTR|TYMS_ENST00000581920.1_3'UTR|ENOSF1_ENST00000319815.6_3'UTR	NM_001071.2	NP_001062.1	P04818	TYSY_HUMAN	thymidylate synthetase	283					DNA repair|DNA replication|phosphatidylinositol-mediated signaling|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to organophosphorus	cytosol	thymidylate synthase activity	p.R283*(1)		endometrium(1)|large_intestine(3)|lung(2)|urinary_tract(2)	8					Capecitabine(DB01101)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Gemcitabine(DB00441)|Leucovorin(DB00650)|Pemetrexed(DB00642)|Raltitrexed(DB00293)|Trifluridine(DB00432)	CAGGATTCTTCGAAAAGTTGA	0.393000													36	37					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133225985	133225985	+	Silent	SNP	G	G	A	rs116482376	by1000genomes	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr12:133225985G>A	ENST00000320574.5	-	31	3955	c.3912C>T	c.(3910-3912)ccC>ccT	p.P1304P	POLE_ENST00000535270.1_Silent_p.P1277P	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1304					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GGATGGCCCCGGGCCTGAGCA	0.662000								DNA polymerases (catalytic subunits)					34	38					0	0	1	0	0
CXCL16	58191	broad.mit.edu	37	17	4638656	4638656	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:4638656C>T	ENST00000293778.6	-	4	928	c.506G>A	c.(505-507)cGc>cAc	p.R169H	CXCL16_ENST00000574412.1_Missense_Mutation_p.R169H|CXCL16_ENST00000576153.1_5'UTR	NM_022059.2	NP_071342.2	Q9H2A7	CXL16_HUMAN	chemokine (C-X-C motif) ligand 16	150					lymphocyte chemotaxis|positive regulation of cell growth|positive regulation of cell migration|receptor-mediated endocytosis|response to interferon-gamma|response to tumor necrosis factor	extracellular space|integral to membrane|plasma membrane	chemokine activity|low-density lipoprotein receptor activity|scavenger receptor activity			large_intestine(2)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5						GAGGGTGGGGCGCTGAGTGGA	0.597000													3	24					0	0	1	0	0
ADAM9	8754	broad.mit.edu	37	8	38865443	38865443	+	Missense_Mutation	SNP	A	A	G			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr8:38865443A>G	ENST00000487273.2	+	2	214	c.136A>G	c.(136-138)Ata>Gta	p.I46V	ADAM9_ENST00000481513.1_Missense_Mutation_p.I46V|ADAM9_ENST00000466936.1_Missense_Mutation_p.I46V	NM_003816.2	NP_003807.1	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9	46				Missing (in Ref. 2; no nucleotide entry).	activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			TTATGAAATTATAACTCCTTG	0.318000													20	21					0	0	1	0	0
SLC20A2	6575	broad.mit.edu	37	8	42275340	42275340	+	Missense_Mutation	SNP	C	C	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr8:42275340C>A	ENST00000342228.3	-	11	2309	c.1940G>T	c.(1939-1941)gGg>gTg	p.G647V	SLC20A2_ENST00000520179.1_Missense_Mutation_p.G647V|SLC20A2_ENST00000520262.1_Missense_Mutation_p.G647V	NM_006749.4	NP_006740.1	Q08357	S20A2_HUMAN	solute carrier family 20 (phosphate transporter), member 2	647					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TGGAAGGATCCCATACATGAG	0.552000													14	56					1.49906e-05	1.56007e-05	1	1	0
UAP1L1	91373	broad.mit.edu	37	9	139972957	139972957	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr9:139972957C>T	ENST00000409858.3	+	3	530	c.498C>T	c.(496-498)taC>taT	p.Y166Y	UAP1L1_ENST00000476184.1_3'UTR|UAP1L1_ENST00000360271.3_Silent_p.Y43Y	NM_207309.2	NP_997192.2	Q3KQV9	UAP1L_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1	166							nucleotidyltransferase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		CTTGCAGGTACGTCATGACCA	0.667000													13	18					0	0	1	0	0
SRCIN1	80725	broad.mit.edu	37	17	36707584	36707584	+	Silent	SNP	G	G	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:36707584G>T	ENST00000264659.7	-	15	2993	c.2769C>A	c.(2767-2769)acC>acA	p.T923T	SRCIN1_ENST00000578925.1_Silent_p.T957T|SRCIN1_ENST00000398579.4_5'UTR	NM_025248.2	NP_079524.2	Q9C0H9	SRCN1_HUMAN	SRC kinase signaling inhibitor 1	795					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	19						CACTGTACTGGGTCAGGGCTG	0.617000													20	20					1.96292e-10	2.07907e-10	1	1	0
ZNF71	58491	broad.mit.edu	37	19	57133398	57133398	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:57133398G>A	ENST00000328070.6	+	3	977	c.743G>A	c.(742-744)gGc>gAc	p.G248D		NM_021216.4	NP_067039.1	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	248						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GGGGACTGCGGCAAGGCCTTC	0.662000													44	86					0	0	1	0	0
DNAJC14	85406	broad.mit.edu	37	12	56221932	56221932	+	Missense_Mutation	SNP	A	A	G			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr12:56221932A>G	ENST00000357606.3	-	3	800	c.511T>C	c.(511-513)Tat>Cat	p.Y171H	DNAJC14_ENST00000317287.5_Missense_Mutation_p.Y171H|DNAJC14_ENST00000317269.3_Missense_Mutation_p.Y171H			Q6Y2X3	DJC14_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 14	171					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			breast(2)|kidney(1)|large_intestine(8)|lung(7)|ovary(3)|prostate(1)|skin(1)	23						TCATCATCATATTCCTCTTCC	0.502000													40	42					0	0	1	0	0
SIL1	64374	broad.mit.edu	37	5	138456752	138456752	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:138456752C>T	ENST00000394817.2	-	3	355	c.216G>A	c.(214-216)ccG>ccA	p.P72P	SIL1_ENST00000265195.5_Silent_p.P72P|SIL1_ENST00000509534.1_Silent_p.P79P	NM_022464.4	NP_071909.1	Q9H173	SIL1_HUMAN	SIL1 nucleotide exchange factor	72	Interaction with HSPA5 and localization to the endoplasmic reticulum (By similarity).				intracellular protein transport|protein folding|transmembrane transport	endoplasmic reticulum lumen	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			ACTCATGCGTCGGGTGGAACA	0.547000									Marinesco-Sjgren syndrome				81	50					0	0	1	0	0
MECP2	4204	broad.mit.edu	37	X	153296733	153296733	+	Missense_Mutation	SNP	T	T	C			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:153296733T>C	ENST00000407218.1	-	5	622	c.437A>G	c.(436-438)cAg>cGg	p.Q146R	MECP2_ENST00000303391.6_Silent_p.P182P|MECP2_ENST00000453960.2_Silent_p.P194P			P51608	MECP2_HUMAN	methyl CpG binding protein 2 (Rett syndrome)	63	MBD.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity			breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|prostate(2)|urinary_tract(1)	23	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGCCAGTTCCTGGAGCTTTGG	0.602000													5	213					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43544969	43544969	+	Missense_Mutation	SNP	C	C	T	rs144575810	byFrequency	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr15:43544969C>T	ENST00000220420.5	-	6	857	c.850G>A	c.(850-852)Gtc>Atc	p.V284I	TGM5_ENST00000349114.4_Missense_Mutation_p.V202I	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	284					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	GTGCACATGACGGCAGCAAAG	0.587000													102	2					0	0	1	0	0
KIF4A	24137	broad.mit.edu	37	X	69607079	69607079	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:69607079C>T	ENST00000374403.3	+	20	2246	c.2164C>T	c.(2164-2166)Cgg>Tgg	p.R722W	KIF4A_ENST00000374388.3_Missense_Mutation_p.R722W	NM_012310.4	NP_036442.3	O95239	KIF4A_HUMAN	kinesin family member 4A	722	Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			breast(6)|endometrium(9)|kidney(3)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	51						CCAGAAACAACGGGAGGTTGC	0.438000													3	6					0	0	1	0	0
WDHD1	11169	broad.mit.edu	37	14	55429738	55429738	+	Silent	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:55429738G>A	ENST00000360586.3	-	19	2528	c.2463C>T	c.(2461-2463)gcC>gcT	p.A821A	WDHD1_ENST00000420358.2_Silent_p.A698A|WDHD1_ENST00000421192.1_Silent_p.A698A|WDHD1_ENST00000359167.4_Silent_p.A339A	NM_007086.3	NP_009017.1	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	821						cytoplasm|nucleoplasm	DNA binding			breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(2)	42						CTGTCAATTCGGCTGCCTTCT	0.383000													12	13					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28651725	28651725	+	Silent	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr18:28651725G>A	ENST00000280904.6	-	13	2414	c.1971C>T	c.(1969-1971)ggC>ggT	p.G657G	DSC2_ENST00000251081.6_Silent_p.G657G	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	657	Cadherin 5.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CACTAGACATGCCAAGTCTAT	0.413000													14	16					0	0	1	0	0
ATL3	25923	broad.mit.edu	37	11	63438805	63438805	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr11:63438805C>T	ENST00000332645.4	-	2	158	c.159G>A	c.(157-159)atG>atA	p.M53I	ATL3_ENST00000535789.1_5'UTR|ATL3_ENST00000538786.1_Intron|ATL3_ENST00000398868.3_Start_Codon_SNP_p.M1I			Q6DD88	ATLA3_HUMAN	atlastin GTPase 3	1					endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	11						GAGGGGACAACATGGAGCCTC	0.687000													3	17					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65134211	65134211	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:65134211C>T	ENST00000358691.5	-	22	2955	c.2789G>A	c.(2788-2790)cGt>cAt	p.R930H	HELZ_ENST00000580168.1_Missense_Mutation_p.R931H	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CTCTTCTACACGTTCCACCAC	0.368000													48	2					0	0	1	0	0
AIM1L	55057	broad.mit.edu	37	1	26669268	26669268	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:26669268C>T	ENST00000527815.1	-	4	608	c.559G>A	c.(559-561)Ggc>Agc	p.G187S	AIM1L_ENST00000308182.5_Missense_Mutation_p.G16S	NM_001039775.3	NP_001034864.2	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	16	Beta/gamma crystallin 'Greek key' 4.						sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|pancreas(1)|skin(2)	12		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		CTTAGGGAGCCGATGCCTTGG	0.597000													105	112					0	0	1	0	0
PABPC3	5042	broad.mit.edu	37	13	25670421	25670421	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr13:25670421G>A	ENST00000281589.3	+	1	122	c.85G>A	c.(85-87)Gag>Aag	p.E29K		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	29	RRM 1.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GATGCTCTACGAGAAGTTCAG	0.627000													55	55					0	0	1	0	0
SH3BP4	23677	broad.mit.edu	37	2	235950972	235950972	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:235950972C>T	ENST00000409212.1	+	4	2066	c.1559C>T	c.(1558-1560)gCc>gTc	p.A520V	SH3BP4_ENST00000344528.4_Missense_Mutation_p.A520V|SH3BP4_ENST00000392011.2_Missense_Mutation_p.A520V			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	520					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GCCCCGGTGGCCCTGCAGCTG	0.567000													12	47					0	0	1	0	0
ERMP1	79956	broad.mit.edu	37	9	5787228	5787228	+	Silent	SNP	A	A	G			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr9:5787228A>G	ENST00000339450.5	-	15	2720	c.2631T>C	c.(2629-2631)ccT>ccC	p.P877P	ERMP1_ENST00000543230.1_3'UTR|ERMP1_ENST00000214893.5_5'UTR|ERMP1_ENST00000381506.3_3'UTR	NM_024896.2	NP_079172.2	Q7Z2K6	ERMP1_HUMAN	endoplasmic reticulum metallopeptidase 1	877					proteolysis	endoplasmic reticulum membrane|integral to membrane	metal ion binding|metallopeptidase activity			endometrium(2)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|skin(1)	20		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00115)|Lung(218;0.111)		CATCCAGTTGAGGGGATCTCT	0.473000													20	26					0	0	1	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1817236	1817236	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:1817236C>T	ENST00000250894.4	+	26	3329	c.3172C>T	c.(3172-3174)Cgc>Tgc	p.R1058C	MAPK8IP3_ENST00000356010.5_Missense_Mutation_p.R1052C	NM_015133.3	NP_055948.2	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting protein 3	1058					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	42						TGTGTACGACCGCGTGTGGTG	0.627000													46	122					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128812	45128812	+	RNA	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:45128812C>T	ENST00000575173.1	-	0	418																											AGTCCTGTTTCTGTGTGGATT	0.373000													5	24					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158900985	158900985	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr6:158900985C>T	ENST00000367097.3	+	7	2586	c.1229C>T	c.(1228-1230)aCt>aTt	p.T410I	TULP4_ENST00000367094.2_Missense_Mutation_p.T410I	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	410	SOCS box.				intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		TACCTCTCCACTGCCTTCATC	0.637000													11	31					0	0	1	0	0
SSU72	29101	broad.mit.edu	37	1	1500071	1500071	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:1500071C>T	ENST00000359060.4	-	2	332	c.306G>A	c.(304-306)gcG>gcA	p.A102A	SSU72_ENST00000291386.3_Intron			Q9NP77	SSU72_HUMAN	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	0					mRNA processing	cytoplasm|nucleus	phosphoprotein phosphatase activity			large_intestine(2)|lung(5)	7	all_cancers(77;0.00125)|all_epithelial(69;0.000703)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.03e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.04e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.72e-23)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;0.000188)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|BRCA - Breast invasive adenocarcinoma(365;0.00837)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		CAGGGTGACACGCCTCCTGTG	0.562000													53	59					0	0	1	0	0
ATAD3C	219293	broad.mit.edu	37	1	1391260	1391260	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:1391260C>T	ENST00000378785.2	+	6	1523	c.528C>T	c.(526-528)taC>taT	p.Y176Y		NM_001039211.2	NP_001034300.2	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	176							ATP binding|nucleoside-triphosphatase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|lung(4)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TCCTGCTGTACGGGCCACCAG	0.627000													19	31					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3900479	3900479	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:3900479G>A	ENST00000262367.5	-	2	1426	c.617C>T	c.(616-618)gCg>gTg	p.A206V	CREBBP_ENST00000382070.3_Missense_Mutation_p.A206V	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	206					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CATGACTTGCGCCTGCCCTTG	0.552000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						27	48					0	0	1	0	0
DLST	1743	broad.mit.edu	37	14	75359578	75359578	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:75359578G>A	ENST00000334220.4	+	8	545	c.484G>A	c.(484-486)Gca>Aca	p.A162T	DLST_ENST00000555190.1_3'UTR|DLST_ENST00000334212.6_Missense_Mutation_p.A76T	NM_001933.4	NP_001924.2	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	162					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(234;0.00698)		TCCTGCTGCTGCAGCCCCAAA	0.572000													26	39					0	0	1	0	0
MT-RNR2	0	broad.mit.edu	37	MT	2492	2492	+	RNA	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrM:2492G>A	ENST00000387347.2	+	0	822					NR_039705.1																						AAACCTTACCCCGCCTGTTTA	0.468000													15	12					0	0	1	0	0
CHD1	1105	broad.mit.edu	37	5	98192247	98192247	+	Missense_Mutation	SNP	T	T	C			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:98192247T>C	ENST00000284049.3	-	35	5119	c.4970A>G	c.(4969-4971)gAt>gGt	p.D1657G		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1657					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	ATACCTATAATCCCTGGAAGA	0.458000													12	27					0	0	1	0	0
DIS3	22894	broad.mit.edu	37	13	73346315	73346315	+	Silent	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr13:73346315G>A	ENST00000377767.4	-	10	1585	c.1485C>T	c.(1483-1485)ctC>ctT	p.L495L	DIS3_ENST00000545453.1_Silent_p.L333L|DIS3_ENST00000377780.4_Silent_p.L465L	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	495					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		TTCCATTTTCGAGTTCTCGAC	0.363000										Multiple Myeloma(4;0.011)			19	20					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40368843	40368843	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:40368843C>T	ENST00000221347.6	-	28	12512	c.12505G>A	c.(12505-12507)Gtg>Atg	p.V4169M		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4169	VWFD 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCGTCGGCCACGGAGACAGGC	0.617000													28	320					0	0	1	0	0
PTPN18	26469	broad.mit.edu	37	2	131116491	131116491	+	Missense_Mutation	SNP	G	G	A	rs11892325	byFrequency	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:131116491G>A	ENST00000175756.5	+	2	246	c.145G>A	c.(145-147)Gtg>Atg	p.V49M	PTPN18_ENST00000347849.3_Intron|PTPN18_ENST00000420717.1_3'UTR	NM_014369.3	NP_055184.2	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	49	Tyrosine-protein phosphatase.					cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)	15	Colorectal(110;0.1)					GTGCTCCACCGTGGCCGGCAG	0.627000													44	68					0	0	1	0	0
STPG1	90529	broad.mit.edu	37	1	24727829	24727829	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:24727829C>T	ENST00000374409.1	-	2	304	c.50G>A	c.(49-51)cGt>cAt	p.R17H	STPG1_ENST00000468303.1_5'UTR|STPG1_ENST00000337248.4_Missense_Mutation_p.R17H|STPG1_ENST00000003583.8_Missense_Mutation_p.V10M|STPG1_ENST00000440416.1_Missense_Mutation_p.V10M	NM_001199012.1	NP_001185941.1			sperm-tail PG-rich repeat containing 1																		TTCACTGGCACGTCTGGGATG	0.418000													3	21					0	0	1	0	0
TMSB15B	286527	broad.mit.edu	37	X	103219162	103219162	+	Missense_Mutation	SNP	A	A	G			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:103219162A>G	ENST00000567181.1	+	2	139	c.67A>G	c.(67-69)Act>Gct	p.T23A	TMSB15B_ENST00000569577.1_Missense_Mutation_p.T23A|TMSB15B_ENST00000436583.1_Missense_Mutation_p.T23A|TMSB15B_ENST00000563257.1_Missense_Mutation_p.T23A|TMSB15B_ENST00000540220.1_Missense_Mutation_p.T23A|TMSB15B_ENST00000419165.1_Missense_Mutation_p.T23A			P0CG34	TB15A_HUMAN	thymosin beta 15B	23					actin cytoskeleton organization|sequestering of actin monomers	cytoplasm|cytoskeleton	actin binding			skin(1)	1						GAAAACTAATACTGAAGAAAA	0.353000													37	34					0	0	1	0	0
FMN1	342184	broad.mit.edu	37	15	33261469	33261469	+	Silent	SNP	G	G	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr15:33261469G>T	ENST00000334528.9	-	4	1763	c.1764C>A	c.(1762-1764)acC>acA	p.T588T	FMN1_ENST00000559047.1_Silent_p.T811T|FMN1_ENST00000561249.1_Silent_p.T713T	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	811	Mediates interaction with alpha-catenin (By similarity).|Microtubule-binding (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		GCTTGAGGAAGGTCTCTCTGT	0.473000													5	190					0.000602214	0.000615979	1	1	0
BAZ1B	9031	broad.mit.edu	37	7	72907249	72907249	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:72907249C>T	ENST00000339594.4	-	5	912	c.574G>A	c.(574-576)Gac>Aac	p.D192N	BAZ1B_ENST00000404251.1_Missense_Mutation_p.D192N	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	192	Mediates the tyrosine-protein kinase activity.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				CGTGCTCTGTCATCTAGTCAA	0.348000													23	10					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228547520	228547520	+	Silent	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:228547520G>A	ENST00000284548.11	+	81	19001	c.18927G>A	c.(18925-18927)gaG>gaA	p.E6309E	OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000366709.4_Silent_p.E3428E|OBSCN_ENST00000366707.4_Intron|OBSCN_ENST00000570156.2_Intron			Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	7132					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CGGAGGCCGAGGCCCACTCTC	0.682000													5	11					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73492436	73492436	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr17:73492436G>A	ENST00000314256.7	+	24	3521	c.3127G>A	c.(3127-3129)Gcc>Acc	p.A1043T	KIAA0195_ENST00000579208.1_Missense_Mutation_p.A694T|KIAA0195_ENST00000375248.5_Missense_Mutation_p.A1053T	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	1043					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CATCAGCATGGCCCAGGCCTC	0.617000													15	131					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31815734	31815734	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr10:31815734G>A	ENST00000446923.2	+	9	3260	c.2869G>A	c.(2869-2871)Ggg>Agg	p.G957R	ZEB1_ENST00000320985.10_Missense_Mutation_p.G973R|ZEB1_ENST00000560721.2_Missense_Mutation_p.G953R|ZEB1_ENST00000361642.5_Missense_Mutation_p.G974R|ZEB1_ENST00000542815.3_Missense_Mutation_p.G906R	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	973					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding	p.G973W(1)		NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				CTCACACTCTGGGTCTTATTC	0.443000													32	0					0	0	1	0	0
IFNLR1	163702	broad.mit.edu	37	1	24484264	24484264	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:24484264G>A	ENST00000327535.1	-	7	931	c.919C>T	c.(919-921)Cga>Tga	p.R307*	IFNLR1_ENST00000374421.3_Nonsense_Mutation_p.R278*|IFNLR1_ENST00000327575.2_3'UTR	NM_170743.3|NM_173064.2	NP_734464.1|NP_775087.1			interferon, lambda receptor 1																		GCCCTGACTCGAGGCGTCGGC	0.577000													98	95					0	0	1	0	0
HR	55806	broad.mit.edu	37	8	21986672	21986672	+	Silent	SNP	C	C	T	rs148136587		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr8:21986672C>T	ENST00000381418.4	-	2	1492	c.12G>A	c.(10-12)acG>acA	p.T4T	HR_ENST00000312841.8_Silent_p.T4T	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	4							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GGAAGCTGGGCGTACTCTCCA	0.632000													48	62					0	0	1	0	0
CLIC4	25932	broad.mit.edu	37	1	25140694	25140694	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:25140694G>A	ENST00000374379.4	+	3	489	c.292G>A	c.(292-294)Gtc>Atc	p.V98I	CLIC4_ENST00000497755.1_3'UTR	NM_013943.2	NP_039234.1	Q9Y696	CLIC4_HUMAN	chloride intracellular channel 4	98	Required for insertion into the membrane (Probable).				cellular response to calcium ion|establishment or maintenance of apical/basal cell polarity|keratinocyte differentiation|negative regulation of cell migration|regulation of cytoskeleton organization	actin cytoskeleton|apical part of cell|cell surface|cell-cell junction|centrosome|chloride channel complex|cytoplasmic vesicle membrane|cytosol|microvillus|midbody|mitochondrion|nuclear matrix|perinuclear region of cytoplasm|soluble fraction	voltage-gated chloride channel activity			large_intestine(3)|lung(2)|skin(1)	6		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000778)|all_lung(284;0.00106)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0479)|OV - Ovarian serous cystadenocarcinoma(117;1.06e-24)|Colorectal(126;1.03e-07)|COAD - Colon adenocarcinoma(152;4.93e-06)|STAD - Stomach adenocarcinoma(196;0.000418)|GBM - Glioblastoma multiforme(114;0.000451)|BRCA - Breast invasive adenocarcinoma(304;0.00215)|KIRC - Kidney renal clear cell carcinoma(1967;0.00216)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.18)		TCTTGAAGAAGTCTTATGCCC	0.403000													46	32					0	0	1	0	0
TADA1	117143	broad.mit.edu	37	1	166829507	166829507	+	Missense_Mutation	SNP	T	T	C			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:166829507T>C	ENST00000367874.4	-	6	701	c.608A>G	c.(607-609)cAt>cGt	p.H203R	TADA1_ENST00000467021.1_5'UTR	NM_053053.3	NP_444281.1	Q96BN2	TADA1_HUMAN	transcriptional adaptor 1	203					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	11						ATATTTAAAATGACCATCTCG	0.358000													23	23					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86259071	86259071	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr15:86259071C>T	ENST00000394518.2	+	20	5747	c.5652C>T	c.(5650-5652)acC>acT	p.T1884T	AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000361243.2_Silent_p.T1888T|AKAP13_ENST00000394510.2_Silent_p.T129T	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1884					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						TGGATGAAACCGCTACCACCC	0.517000													14	47					0	0	1	0	0
PASK	23178	broad.mit.edu	37	2	242078093	242078093	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:242078093C>T	ENST00000403638.3	-	5	808	c.717G>A	c.(715-717)tcG>tcA	p.S239S	PASK_ENST00000539818.1_Silent_p.S23S|PASK_ENST00000405260.1_Silent_p.S239S|PASK_ENST00000544142.1_Silent_p.S53S|PASK_ENST00000234040.4_Silent_p.S239S|PASK_ENST00000358649.4_Silent_p.S239S	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	239					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CGACCCAGGTCGAGACCCTCT	0.602000													32	50					0	0	1	0	0
TEKT4	150483	broad.mit.edu	37	2	95537621	95537621	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:95537621C>T	ENST00000295201.4	+	1	434	c.297C>T	c.(295-297)caC>caT	p.H99H	AC097374.2_ENST00000568768.1_RNA|TEKT4_ENST00000427593.2_Silent_p.H99H	NM_144705.2	NP_653306.1	Q8WW24	TEKT4_HUMAN	tektin 4	99					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	28						AGGACACGCACAGCTGGAAGT	0.687000													3	16					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76877132	76877132	+	Missense_Mutation	SNP	A	A	G			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr11:76877132A>G	ENST00000409709.3	+	15	1993	c.1721A>G	c.(1720-1722)cAt>cGt	p.H574R	MYO7A_ENST00000458637.2_Missense_Mutation_p.H574R|MYO7A_ENST00000409893.1_Missense_Mutation_p.H574R|MYO7A_ENST00000409619.2_Missense_Mutation_p.H563R	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	574	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GACACCCTGCATGGGGACATT	0.562000													10	33					0	0	1	0	0
NEUROD1	4760	broad.mit.edu	37	2	182543459	182543459	+	Silent	SNP	G	G	A	rs116321775	byFrequency	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:182543459G>A	ENST00000295108.3	-	2	586	c.129C>T	c.(127-129)ctC>ctT	p.L43L	NEUROD1_ENST00000496876.1_Intron|CERKL_ENST00000479558.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	43					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TCATGGTTTCGAGGTCGTCCT	0.582000													28	15					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1270130	1270130	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:1270130C>T	ENST00000348261.5	+	35	6446	c.6198C>T	c.(6196-6198)agC>agT	p.S2066S	CACNA1H_ENST00000358590.4_Silent_p.S2060S|CACNA1H_ENST00000565831.1_Silent_p.S2060S	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	2066					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GGCCCGCCAGCGTCCGCACTC	0.721000													16	4					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70225900	70225900	+	Missense_Mutation	SNP	C	C	T	rs150507629		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:70225900C>T	ENST00000310961.5	+	4	446	c.28C>T	c.(28-30)Cgg>Tgg	p.R10W	LRRC7_ENST00000370958.1_Missense_Mutation_p.R43W|LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000035383.5_Missense_Mutation_p.R5W			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	5						centrosome|focal adhesion|nucleolus	protein binding	p.R5W(2)|p.R43W(1)		breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						GACCACCAAACGGAAAATCAT	0.458000													21	20					0	0	1	0	0
NUDCD3	23386	broad.mit.edu	37	7	44530146	44530146	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:44530146C>T	ENST00000355451.6	-	1	333	c.54G>A	c.(52-54)caG>caA	p.Q18Q		NM_015332.3	NP_056147.2	Q8IVD9	NUDC3_HUMAN	NudC domain containing 3	18										endometrium(2)|large_intestine(1)|lung(3)|skin(1)	7						TGCCCACGTGCTGCAGGATGC	0.622000													15	6					0	0	1	0	0
TCTN1	79600	broad.mit.edu	37	12	111064170	111064170	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr12:111064170C>T	ENST00000551590.1	+	3	501	c.345C>T	c.(343-345)ggC>ggT	p.G115G	TCTN1_ENST00000551555.2_3'UTR|TCTN1_ENST00000471804.2_Silent_p.G115G|TCTN1_ENST00000397659.4_Silent_p.G115G|TCTN1_ENST00000377654.3_5'UTR|TCTN1_ENST00000550703.2_Silent_p.G115G|TCTN1_ENST00000397655.3_Silent_p.G115G			Q2MV58	TECT1_HUMAN	tectonic family member 1	115					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						ttttCAGGGGCGACAGCCAGT	0.318000													5	1					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135304341	135304341	+	Silent	SNP	T	T	C			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:135304341T>C	ENST00000285968.6	+	29	4160	c.4134T>C	c.(4132-4134)ccT>ccC	p.P1378P		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	1378					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						TCACCTCACCTCCTCCTGAAG	0.438000													7	51					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65342632	65342632	+	Silent	SNP	T	T	C			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:65342632T>C	ENST00000402939.2	-	23	3809	c.3810A>G	c.(3808-3810)agA>agG	p.R1270R	MAGI1_ENST00000330909.8_3'UTR	NM_001033057.1	NP_001028229.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	1299					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TGCTATACTCTCTGCTGCCTT	0.587000													31	83					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13177	13177	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrM:13177G>A	ENST00000361567.2	+	1	841	c.841G>A	c.(841-843)Ggc>Agc	p.G281S				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	281					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	CACTATGCTTAGGCGCTATCA	0.448000													14	32					0	0	1	0	0
PHF16	0	broad.mit.edu	37	X	46913859	46913859	+	Silent	SNP	G	G	A	rs140782937	byFrequency	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:46913859G>A	ENST00000218343.4	+	9	1570	c.1272G>A	c.(1270-1272)acG>acA	p.T424T	PHF16_ENST00000397189.1_Silent_p.T424T	NM_014735.3	NP_055550.1	Q92613	JADE3_HUMAN		424					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(2)	33						GTATGCCCACGCTAGCTGTGG	0.493000													15	68					0	0	1	0	0
EFCAB12	90288	broad.mit.edu	37	3	129127605	129127605	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:129127605C>T	ENST00000505956.1	-	6	1294	c.1132G>A	c.(1132-1134)Ggg>Agg	p.G378R	EFCAB12_ENST00000326085.3_Missense_Mutation_p.G378R	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		CTCATATCCCCGTGGATGGTG	0.582000													3	11					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56274661	56274661	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr18:56274661C>T	ENST00000361673.3	-	3	333	c.120G>A	c.(118-120)aaG>aaA	p.K40K		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	40	Ig-like 1.						ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TTACCTCTGGCTTGGGCTGAC	0.348000													16	18					0	0	1	0	0
CDHR5	53841	broad.mit.edu	37	11	619490	619490	+	Missense_Mutation	SNP	C	C	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr11:619490C>A	ENST00000358353.3	-	12	1599	c.1277G>T	c.(1276-1278)gGa>gTa	p.G426V	CDHR5_ENST00000397542.2_Missense_Mutation_p.G426V|CDHR5_ENST00000349570.7_Missense_Mutation_p.G426V			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	426	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						GTAGAAGGCTCCCGCCTGTGC	0.607000													45	2					6.18754e-15	6.67211e-15	1	1	0
RRN3P2	0	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													4	31					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	48953760	48953760	+	Nonsense_Mutation	SNP	C	C	T	rs121913302		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr13:48953760C>T	ENST00000267163.4	+	14	1501	c.1363C>T	c.(1363-1365)Cga>Tga	p.R455*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	455	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(8)|p.R455*(7)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTGTATTACCGAGTAATGGA	0.358000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			2	0					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24885925	24885925	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:24885925C>T	ENST00000382554.3	+	9	5288	c.4970C>T	c.(4969-4971)aCg>aTg	p.T1657M		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1657	Integrase catalytic.				DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TACACACACACGGCTGTGGCC	0.602000													22	22					0	0	1	0	0
AIP	9049	broad.mit.edu	37	11	67254583	67254583	+	Missense_Mutation	SNP	A	A	G			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr11:67254583A>G	ENST00000279146.3	+	2	324	c.206A>G	c.(205-207)aAg>aGg	p.K69R		NM_003977.2	NP_003968.2	O00170	AIP_HUMAN	aryl hydrocarbon receptor interacting protein	69	PPIase FKBP-type.				protein maturation by protein folding|protein targeting to mitochondrion	nucleus	signal transducer activity|transcription coactivator activity|transcription factor binding|unfolded protein binding			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(2)	7						AAGAAGTTCAAGCTGCCTGTG	0.592000									Familial Isolated Pituitary Adenoma				70	102					0	0	1	0	0
SORCS2	57537	broad.mit.edu	37	4	7725501	7725501	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr4:7725501C>T	ENST00000507866.2	+	19	2611	c.2502C>T	c.(2500-2502)acC>acT	p.T834T	SORCS2_ENST00000329016.9_Silent_p.T662T	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	834	PKD.					integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						TTACACTGACCGGGGAGCCCA	0.612000													32	4					0	0	1	0	0
METTL14	57721	broad.mit.edu	37	4	119621741	119621741	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr4:119621741C>T	ENST00000388822.4	+	8	849	c.682C>T	c.(682-684)Cga>Tga	p.R228*	METTL14_ENST00000506780.1_Nonsense_Mutation_p.R190*			Q9HCE5	MTL14_HUMAN	methyltransferase like 14	228						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|stomach(1)	16						TGCAGCACCTCGATCATTTAT	0.338000													24	31					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154157053	154157053	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:154157053C>T	ENST00000360256.4	-	14	5212	c.5012G>A	c.(5011-5013)cGt>cAt	p.R1671H		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1671					acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AAGAGTAGTACGAGTTATTTC	0.408000													42	43					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86122535	86122535	+	Silent	SNP	G	G	A	rs140888795		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr15:86122535G>A	ENST00000394518.2	+	7	1331	c.1236G>A	c.(1234-1236)acG>acA	p.T412T	RP11-815J21.2_ENST00000561409.1_RNA|AKAP13_ENST00000361243.2_Silent_p.T412T	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	412					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						TAAAGGGCACGGAAGGCCTTT	0.512000													42	44					0	0	1	0	0
SLC24A2	25769	broad.mit.edu	37	9	19786016	19786016	+	Silent	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr9:19786016G>A	ENST00000341998.2	-	1	910	c.849C>T	c.(847-849)aaC>aaT	p.N283N	SLC24A2_ENST00000286344.3_Silent_p.N283N	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	283					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		CTACTTGGACGTTGAATTTCA	0.408000													37	54					0	0	1	0	0
ZNF574	64763	broad.mit.edu	37	19	42584536	42584536	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:42584536G>A	ENST00000600245.1	+	2	2433	c.1778G>A	c.(1777-1779)cGc>cAc	p.R593H	ZNF574_ENST00000222339.7_Missense_Mutation_p.R683H|ZNF574_ENST00000359044.4_Missense_Mutation_p.R593H			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	593					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				CGTCCTTACCGCCTGCTCATG	0.612000													41	86					0	0	1	0	0
SLC25A27	9481	broad.mit.edu	37	6	46623609	46623609	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr6:46623609C>T	ENST00000371347.5	+	2	388	c.136C>T	c.(136-138)Cga>Tga	p.R46*	SLC25A27_ENST00000452689.2_5'UTR|SLC25A27_ENST00000411689.2_Nonsense_Mutation_p.R46*	NM_001204051.1|NM_004277.4	NP_001190980.1|NP_004268.3	O95847	UCP4_HUMAN	solute carrier family 25, member 27	46					generation of precursor metabolites and energy|transport	integral to membrane|mitochondrial inner membrane				central_nervous_system(1)|kidney(1)|lung(4)|prostate(1)|urinary_tract(1)	8			Lung(136;0.192)			CACAAAAACTCGACTCCAAAT	0.458000													31	32					0	0	1	0	0
KLC1	3831	broad.mit.edu	37	14	104124027	104124027	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:104124027C>T	ENST00000389744.4	+	3	675	c.406C>T	c.(406-408)Cag>Tag	p.Q136*	KLC1_ENST00000555836.1_Nonsense_Mutation_p.Q136*|KLC1_ENST00000347839.6_Nonsense_Mutation_p.Q136*|RP11-73M18.2_ENST00000472726.2_Nonsense_Mutation_p.Q308*|KLC1_ENST00000452929.2_Nonsense_Mutation_p.Q136*|KLC1_ENST00000348520.6_Nonsense_Mutation_p.Q136*|KLC1_ENST00000553286.1_Nonsense_Mutation_p.Q136*|KLC1_ENST00000554280.1_Nonsense_Mutation_p.Q136*|KLC1_ENST00000557575.1_Nonsense_Mutation_p.Q136*|KLC1_ENST00000334553.6_Nonsense_Mutation_p.Q136*|KLC1_ENST00000445352.4_Nonsense_Mutation_p.Q136*|KLC1_ENST00000380038.3_Nonsense_Mutation_p.Q136*|KLC1_ENST00000246489.7_Nonsense_Mutation_p.Q136*|KLC1_ENST00000557450.1_Nonsense_Mutation_p.Q136*			Q07866	KLC1_HUMAN	kinesin light chain 1	136					blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding		KLC1/ALK(2)	NS(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	12		Melanoma(154;0.155)|all_epithelial(191;0.19)				GAAGAGTGAGCAGTCTGTGGC	0.507000													27	74					0	0	1	0	0
C5orf15	56951	broad.mit.edu	37	5	133292586	133292586	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:133292586C>T	ENST00000231512.3	-	3	964	c.762G>A	c.(760-762)atG>atA	p.M254I		NM_020199.2	NP_064584.1	Q8NC54	KCT2_HUMAN	chromosome 5 open reading frame 15	254						integral to membrane				endometrium(2)|large_intestine(1)|lung(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)			TCAAAGAAGGCATTGCCTCAT	0.338000													11	52					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:195505836G>C	ENST00000463781.3	-	2	13074	c.12615C>G	c.(12613-12615)caC>caG	p.H4205Q	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.H4205Q	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	968					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.H4205Q(10)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597000													3	3					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16327921	16327921	+	Missense_Mutation	SNP	C	C	A	rs142039862	by1000genomes	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr6:16327921C>A	ENST00000244769.4	-	8	1557	c.621G>T	c.(619-621)caG>caT	p.Q207H	ATXN1_ENST00000436367.1_Missense_Mutation_p.Q207H	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	207	Poly-Gln.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association	p.Q207H(2)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				gctgatgctgctgctgctgct	0.662000													3	16					1	1	1	1	0
RASSF5	83593	broad.mit.edu	37	1	206711576	206711576	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:206711576G>A	ENST00000338603.2	+	2	590	c.533G>A	c.(532-534)cGg>cAg	p.R178Q	RASSF5_ENST00000367117.3_Missense_Mutation_p.R178Q|RASSF5_ENST00000355294.4_Missense_Mutation_p.R178Q	NM_182663.2	NP_872604.1	Q8WWW0	RASF5_HUMAN	Ras association (RalGDS/AF-6) domain family member 5	178					apoptosis|intracellular signal transduction	cytoplasm|microtubule	metal ion binding|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	8	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			GGTTTATCCCGGGACAGACCC	0.567000													134	87					0	0	1	0	0
NSL1	25936	broad.mit.edu	37	1	212964879	212964879	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:212964879G>A	ENST00000366977.3	-	1	245	c.227C>T	c.(226-228)gCg>gTg	p.A76V	NSL1_ENST00000473995.1_5'UTR|NSL1_ENST00000366975.6_Missense_Mutation_p.A76V|NSL1_ENST00000422588.2_Missense_Mutation_p.A76V|NSL1_ENST00000366976.1_Missense_Mutation_p.A76V|NSL1_ENST00000366978.1_5'UTR	NM_015471.3	NP_056286.3	Q96IY1	NSL1_HUMAN	NSL1, MIS12 kinetochore complex component	76					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	9				OV - Ovarian serous cystadenocarcinoma(81;0.00597)|all cancers(67;0.00893)|GBM - Glioblastoma multiforme(131;0.0514)|Epithelial(68;0.102)		TACCCACTGCGCATCTCGCAG	0.582000													5	236					0	0	1	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935381	151935381	+	Silent	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:151935381G>A	ENST00000393902.3	-	3	1353	c.786C>T	c.(784-786)ccC>ccT	p.P262P	MAGEA3_ENST00000370278.3_Silent_p.P262P			P43357	MAGA3_HUMAN	melanoma antigen family A, 3	262	MAGE.									endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	15	Acute lymphoblastic leukemia(192;6.56e-05)					GATCACTGCCGGGGACCTGCC	0.527000													59	179					0	0	1	0	0
GJB3	2707	broad.mit.edu	37	1	35250835	35250835	+	Missense_Mutation	SNP	A	A	G			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:35250835A>G	ENST00000373366.2	+	2	1087	c.472A>G	c.(472-474)Atg>Gtg	p.M158V	RP1-34M23.5_ENST00000542839.1_RNA|GJB3_ENST00000373362.3_Missense_Mutation_p.M158V	NM_024009.2	NP_076872.1	O75712	CXB3_HUMAN	gap junction protein, beta 3, 31kDa	158					cell communication	connexon complex|integral to membrane	gap junction channel activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(2)|prostate(3)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				TGGCTTCAATATGCCGCGCCT	0.552000													69	60					0	0	1	0	0
TUBB1	81027	broad.mit.edu	37	20	57599552	57599552	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr20:57599552C>T	ENST00000217133.1	+	4	1339	c.1070C>T	c.(1069-1071)cCg>cTg	p.P357L		NM_030773.3	NP_110400.1	Q9H4B7	TBB1_HUMAN	tubulin, beta 1 class VI	357					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|skin(2)	16	all_lung(29;0.00711)		Colorectal(105;0.109)		Colchicine(DB01394)|Docetaxel(DB01248)|Paclitaxel(DB01229)|Vindesine(DB00309)	TGCGACATCCCGCCCCGGGGG	0.552000													32	48					0	0	1	0	0
GNB1	2782	broad.mit.edu	37	1	1747258	1747258	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:1747258G>A	ENST00000378609.4	-	5	471	c.140C>T	c.(139-141)aCg>aTg	p.T47M		NM_002074.3	NP_002065.1	P62873	GBB1_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 1	47					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	12	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		TGTCCTCCTCGTGCGCATTTG	0.488000													11	29					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22928123	22928123	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:22928123C>T	ENST00000166244.3	+	17	2979	c.2907C>T	c.(2905-2907)gaC>gaT	p.D969D		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	969	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TTCACAGGGACGTGCGCGCCC	0.697000													5	10					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23080502	23080502	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:23080502C>T	ENST00000219689.7	-	16	2923	c.2924G>A	c.(2923-2925)cGc>cAc	p.R975H	USP31_ENST00000567975.1_Missense_Mutation_p.R268H	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	975	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity	p.R975H(1)		breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		CGGGGGCAGGCGGTCCCCTTG	0.517000													40	52					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65270419	65270419	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:65270419C>T	ENST00000389722.3	-	3	433	c.380G>A	c.(379-381)cGt>cAt	p.R127H	SPTB_ENST00000556626.1_Missense_Mutation_p.R127H|SPTB_ENST00000542895.1_Missense_Mutation_p.R127H|SPTB_ENST00000389720.3_Missense_Mutation_p.R127H|SPTB_ENST00000389721.5_Missense_Mutation_p.R127H	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	127	Actin-binding.|CH 1.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CAGGTGTACACGCTGCTCCTT	0.607000													13	43					0	0	1	0	0
FAM179B	23116	broad.mit.edu	37	14	45481246	45481246	+	Missense_Mutation	SNP	T	T	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:45481246T>A	ENST00000361462.2	+	7	3389	c.3206T>A	c.(3205-3207)aTt>aAt	p.I1069N	KLHL28_ENST00000553817.1_Intron|FAM179B_ENST00000361577.3_Missense_Mutation_p.I1069N|FAM179B_ENST00000382233.2_Missense_Mutation_p.N991K			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	1069	Ser-rich.						binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						AAGAAAAAAATTTCTCATATT	0.294000													4	44					0	0	1	0	0
BNC2	54796	broad.mit.edu	37	9	16419174	16419174	+	Missense_Mutation	SNP	T	T	C			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr9:16419174T>C	ENST00000380672.4	-	7	3170	c.3113A>G	c.(3112-3114)aAc>aGc	p.N1038S	BNC2_ENST00000380667.2_Missense_Mutation_p.N971S|BNC2_ENST00000545497.1_Missense_Mutation_p.N943S	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	1038					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		GTGGCAAATGTTGCACATGAT	0.512000													22	29					0	0	1	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276918	71276918	+	Silent	SNP	C	C	T	rs36179995		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr11:71276918C>T	ENST00000398531.1	+	1	310	c.285C>T	c.(283-285)ggC>ggT	p.G95G	KRTAP5-10_ENST00000376536.4_Intron	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	95	7 X 4 AA repeats of C-C-X-P.					keratin filament		p.G95G(1)		endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						GGGGCTGTGGCTCCTGTGGGG	0.687000													7	93					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43043173	43043173	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr20:43043173C>T	ENST00000316099.3	+	5	608	c.519C>T	c.(517-519)aaC>aaT	p.N173N	HNF4A_ENST00000415691.1_Silent_p.N173N|HNF4A_ENST00000443598.2_Silent_p.N173N|HNF4A_ENST00000457232.1_Silent_p.N151N	NM_000457.4|NM_001258355.1	NP_000448.3|NP_001245284.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	173					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CCGGGATCAACGGCGACATTC	0.582000													25	47					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145075040	145075040	+	Missense_Mutation	SNP	C	C	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:145075040C>A	ENST00000369345.4	-	2	468	c.254G>T	c.(253-255)gGc>gTc	p.G85V	PDE4DIP_ENST00000530740.1_Intron|PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000369348.3_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTCCATCCAGCCATCAGGCAG	0.502000			T	PDGFRB	MPD								6	47					0.00116845	0.00118836	1	1	0
FOXA2	3170	broad.mit.edu	37	20	22563241	22563241	+	Missense_Mutation	SNP	G	G	C			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr20:22563241G>C	ENST00000419308.2	-	2	823	c.621C>G	c.(619-621)atC>atG	p.I207M	FOXA2_ENST00000377115.4_Missense_Mutation_p.I207M|FOXA2_ENST00000319993.4_Missense_Mutation_p.I213M	NM_021784.4	NP_068556.2	Q9Y261	FOXA2_HUMAN	forkhead box A2	207					cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|urinary_tract(1)	22	Lung NSC(19;0.188)					GCGAGTGGCGGATGGAGTTCT	0.617000													61	30					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871064	170871064	+	Silent	SNP	G	G	A	rs112748399		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr6:170871064G>A	ENST00000392092.2	+	3	519	c.240G>A	c.(238-240)caG>caA	p.Q80Q	TBP_ENST00000230354.6_Silent_p.Q80Q|TBP_ENST00000540980.1_Silent_p.Q60Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	80	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.577000													6	51					0	0	1	0	0
MED12	9968	broad.mit.edu	37	X	70344032	70344032	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:70344032C>T	ENST00000333646.6	+	13	1967	c.1768C>T	c.(1768-1770)Cgg>Tgg	p.R590W	MED12_ENST00000374080.3_Missense_Mutation_p.R590W|MED12_ENST00000374102.1_Missense_Mutation_p.R590W	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	590					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					TGAGAGTGAGCGGGTGGAATT	0.473000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						22	29					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43574783	43574783	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr15:43574783C>T	ENST00000452443.2	-	8	1044	c.1040G>A	c.(1039-1041)cGg>cAg	p.R347Q		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	347					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	GAGATCTTTCCGGATCATCCA	0.552000													3	2					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183721107	183721107	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr4:183721107G>A	ENST00000511685.1	+	28	7826	c.7703G>A	c.(7702-7704)cGc>cAc	p.R2568H	TENM3_ENST00000406950.2_Missense_Mutation_p.R2568H					teneurin transmembrane protein 3																		ACCAGCGGCCGCAAGGCGCTG	0.642000													15	0					0	0	1	0	0
ZNF83	55769	broad.mit.edu	37	19	53116462	53116462	+	Silent	SNP	A	A	G			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:53116462A>G	ENST00000597597.1	-	2	3609	c.1356T>C	c.(1354-1356)acT>acC	p.T452T	ZNF83_ENST00000601257.1_Intron|ZNF83_ENST00000600714.1_Intron|ZNF83_ENST00000544146.1_Silent_p.T452T|ZNF83_ENST00000541777.2_Silent_p.T452T|ZNF83_ENST00000536937.1_Silent_p.T452T|ZNF83_ENST00000545872.1_Silent_p.T452T|ZNF83_ENST00000301096.3_Silent_p.T452T|ZNF83_ENST00000391789.4_Silent_p.T424T			P51522	ZNF83_HUMAN	zinc finger protein 83	452						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		GTTTCTCTCCAGTGTGAATTT	0.388000													41	211					0	0	1	0	0
APAF1	317	broad.mit.edu	37	12	99053108	99053108	+	Missense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr12:99053108C>T	ENST00000357310.1	+	5	1274	c.697C>T	c.(697-699)Cgc>Tgc	p.R233C	APAF1_ENST00000359972.2_Missense_Mutation_p.R222C|APAF1_ENST00000333991.1_Missense_Mutation_p.R233C|APAF1_ENST00000549007.1_Missense_Mutation_p.R233C|APAF1_ENST00000339433.3_Missense_Mutation_p.R233C|APAF1_ENST00000550527.1_Missense_Mutation_p.R222C|APAF1_ENST00000547045.1_Missense_Mutation_p.R233C|APAF1_ENST00000552268.1_Missense_Mutation_p.R233C|APAF1_ENST00000551964.1_Missense_Mutation_p.R233C	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	233	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	TCTGATGCTTCGCAAACACCC	0.453000													12	10					0	0	1	0	0
PADI1	29943	broad.mit.edu	37	1	17570624	17570624	+	Silent	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:17570624C>T	ENST00000375471.4	+	16	1970	c.1878C>T	c.(1876-1878)caC>caT	p.H626H	PADI1_ENST00000536552.1_Silent_p.H97H|PADI1_ENST00000537499.1_Silent_p.H183H|PADI1_ENST00000460293.1_3'UTR|PADI1_ENST00000413717.2_Silent_p.H141H	NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	626					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	TGGGCCTGCACTGCATCTTCA	0.597000													39	38					0	0	1	0	0
LRRC43	254050	broad.mit.edu	37	12	122672355	122672355	+	Silent	SNP	C	C	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr12:122672355C>A	ENST00000339777.4	+	4	658	c.630C>A	c.(628-630)ccC>ccA	p.P210P	LRRC43_ENST00000425921.1_Silent_p.P25P	NM_152759.4	NP_689972.3	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43	210										NS(1)|endometrium(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(2)	19	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		TTCTAGGCCCCTTGGAAAGTC	0.562000													25	12					1.55811e-20	1.69031e-20	1	1	0
ZNF804B	219578	broad.mit.edu	37	7	88963258	88963258	+	Missense_Mutation	SNP	A	A	G			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:88963258A>G	ENST00000333190.4	+	4	1571	c.962A>G	c.(961-963)cAt>cGt	p.H321R		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	321						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			ATTGGCATTCATGCTTCATTC	0.328000										HNSCC(36;0.09)			14	32					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58587675	58587675	+	Missense_Mutation	SNP	A	A	G			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr20:58587675A>G	ENST00000348616.4	+	18	2689	c.2389A>G	c.(2389-2391)Agc>Ggc	p.S797G	CDH26_ENST00000244049.3_Missense_Mutation_p.S89G|CDH26_ENST00000497614.1_3'UTR|CDH26_ENST00000350849.6_Missense_Mutation_p.S130G|CDH26_ENST00000244047.5_Intron	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	256					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CCCATCCCTCAGCTCTCTGGC	0.537000													65	35					0	0	1	0	0
OR2A14	135941	broad.mit.edu	37	7	143826872	143826872	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:143826872G>A	ENST00000408899.2	+	1	722	c.667G>A	c.(667-669)Gcc>Acc	p.A223T		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	223					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					CATCCTGGCCGCCATCTTGAG	0.607000													5	296					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187509884	187509884	+	Silent	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr4:187509884G>A	ENST00000441802.2	-	27	13838	c.13629C>T	c.(13627-13629)acC>acT	p.T4543T		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4543					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AGCAGGAGGCGGTGGAGGCGT	0.597000										HNSCC(5;0.00058)			14	1					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51254739	51254739	+	Missense_Mutation	SNP	C	C	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:51254739C>A	ENST00000404971.1	-	2	2012	c.673G>T	c.(673-675)Ggc>Tgc	p.G225C	NRXN1_ENST00000405472.3_Missense_Mutation_p.G225C|NRXN1_ENST00000401669.2_Missense_Mutation_p.G225C|NRXN1_ENST00000402717.3_Missense_Mutation_p.G225C|NRXN1_ENST00000406859.3_Missense_Mutation_p.G225C|NRXN1_ENST00000405581.1_Missense_Mutation_p.G225C|NRXN1_ENST00000406316.2_Missense_Mutation_p.G225C	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	225	EGF-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CACACCCCGCCCTCGCCCTCC	0.716000													7	8					0.00198382	0.00200623	1	1	0
LPP	4026	broad.mit.edu	37	3	188590444	188590444	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:188590444C>T	ENST00000312675.4	+	10	1849	c.1603C>T	c.(1603-1605)Cga>Tga	p.R535*	LPP_ENST00000543006.1_Nonsense_Mutation_p.R535*	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	535	LIM zinc-binding 3.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		ATTTGCCCCGCGATGTTCTGT	0.527000			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								46	2					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38139340	38139340	+	Missense_Mutation	SNP	G	G	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:38139340G>A	ENST00000308059.6	+	18	2692	c.2671G>A	c.(2671-2673)Gcc>Acc	p.A891T	DLEC1_ENST00000452631.2_Missense_Mutation_p.A891T|DLEC1_ENST00000346219.3_Missense_Mutation_p.A891T			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	891					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CCAGCTCCCAGCCACATGGCG	0.597000													37	0					0	0	1	0	0
RMDN2	151393	broad.mit.edu	37	2	38178932	38178932	+	Missense_Mutation	SNP	A	A	G			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:38178932A>G	ENST00000407257.1	+	2	721	c.574A>G	c.(574-576)Aca>Gca	p.T192A	RMDN2_ENST00000402091.3_Missense_Mutation_p.T192A|RMDN2_ENST00000354545.2_Intron|RMDN2_ENST00000417700.2_Intron|RMDN2-AS1_ENST00000414365.2_RNA|RMDN2_ENST00000406384.1_Intron|RMDN2_ENST00000234195.3_Missense_Mutation_p.T192A					regulator of microtubule dynamics 2																		GAATTTTGAAACAAACACTAC	0.333000													39	39					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176721178	176721178	+	Missense_Mutation	SNP	C	C	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr5:176721178C>A	ENST00000439151.2	+	23	6854	c.6809C>A	c.(6808-6810)gCa>gAa	p.A2270E	NSD1_ENST00000347982.4_Missense_Mutation_p.A2001E|NSD1_ENST00000361032.4_Missense_Mutation_p.A2167E|NSD1_ENST00000354179.4_Missense_Mutation_p.A2001E	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2270	Pro-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AAAGCTCTGGCAGGGACTTGT	0.532000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			104	109					1.53058e-52	1.7017e-52	1	1	0
ANK3	288	broad.mit.edu	37	10	61829384	61829384	+	Missense_Mutation	SNP	C	C	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr10:61829384C>A	ENST00000280772.1	-	37	11446	c.11255G>T	c.(11254-11256)tGt>tTt	p.C3752F	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3752					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TAATCCCTGACAACTGGTCAT	0.398000													54	6					1.46156e-29	1.61493e-29	1	1	0
ZBTB40	9923	broad.mit.edu	37	1	22838561	22838563	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:22838561_22838563delAAG	ENST00000404138.1	+	12	2906_2908	c.2395_2397delAAG	c.(2395-2397)del	p.K803del	ZBTB40_ENST00000374651.4_In_Frame_Del_p.K691del|ZBTB40_ENST00000375647.4_In_Frame_Del_p.K803del	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	803					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		CGATGCCCCCAAGAAGAAGAAGA	0.517													12	114	---	---	---	---					
LRRC41	10489	broad.mit.edu	37	1	46751419	46751421	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:46751419_46751421delAGA	ENST00000343304.6	-	4	1393_1395	c.1108_1110delTCT	c.(1108-1110)del	p.S370del	LRRC41_ENST00000472710.1_5'UTR	NM_006369.4	NP_006360.3	Q15345	LRC41_HUMAN	leucine rich repeat containing 41	370										breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					ATGAGGATGTAGAAGAAGAGGCA	0.606													26	122	---	---	---	---					
FPGT-TNNI3K	0	broad.mit.edu	37	1	74797186	74797186	+	Frame_Shift_Del	DEL	T	T	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr1:74797186delT	ENST00000370895.1	+	8	835	c.800delT	c.(799-801)gtfs	p.V267fs	TNNI3K_ENST00000370891.2_Frame_Shift_Del_p.V267fs|FPGT-TNNI3K_ENST00000557284.1_Frame_Shift_Del_p.V267fs|FPGT-TNNI3K_ENST00000370899.3_Frame_Shift_Del_p.V267fs|TNNI3K_ENST00000326637.3_Frame_Shift_Del_p.V166fs			Q59H18	TNI3K_HUMAN		166						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										CAAGATGCAGTTTTTTTCACT	0.398													12	13	---	---	---	---					
LHCGR	3973	broad.mit.edu	37	2	48925846	48925846	+	Frame_Shift_Del	DEL	T	T	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:48925846delT	ENST00000294954.7	-	9	795	c.774delA	c.(772-774)aafs	p.K258fs	LHCGR_ENST00000405626.1_Frame_Shift_Del_p.K258fs|LHCGR_ENST00000403273.1_Frame_Shift_Del_p.K258fs|STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000401907.1_Frame_Shift_Del_p.K258fs|LHCGR_ENST00000344775.3_Intron	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	258					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	TTGATGGCAATTTTTTTAGAG	0.453													14	42	---	---	---	---					
CCDC74B-AS1	0	broad.mit.edu	37	2	130893080	130893081	+	RNA	INS	-	-	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr2:130893080_130893081insA	ENST00000427638.1	+	0	541_542					NR_033903.1																						gactccatctcaaaaaaaaaaa	0.564													2	4	---	---	---	---					
RP11-553L6.2	0	broad.mit.edu	37	3	113951739	113951739	+	RNA	DEL	C	C	-	rs75864387		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:113951739delC	ENST00000493033.1	+	0	160				RP11-553L6.2_ENST00000481773.1_RNA																							CTGCCCCCTGCCCCCCCCCCA	0.652													2	4	---	---	---	---					
KALRN	8997	broad.mit.edu	37	3	124157839	124157840	+	Frame_Shift_Ins	INS	-	-	C			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr3:124157839_124157840insC	ENST00000360013.3	+	18	3274_3275	c.3147_3148insC	c.(3145-3150)atccctfs	p.IP1049fs	KALRN_ENST00000240874.3_Frame_Shift_Ins_p.IP1049fs|KALRN_ENST00000460856.1_Frame_Shift_Ins_p.IP1040fs	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1049					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						ACCATGTCATTCCCCTCATCAG	0.525													24	27	---	---	---	---					
SULT1B1	27284	broad.mit.edu	37	4	70620807	70620807	+	Frame_Shift_Del	DEL	T	T	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr4:70620807delT	ENST00000310613.2	-	2	426	c.129delA	c.(127-129)atfs	p.I43fs		NM_014465.3	NP_055280.2	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member 1	43					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol				breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(14)|prostate(1)|upper_aerodigestive_tract(1)	24						GATAAGTGGCTATCACAATGT	0.408													64	49	---	---	---	---					
ANKIB1	54467	broad.mit.edu	37	7	91936913	91936914	+	Frame_Shift_Ins	INS	-	-	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:91936913_91936914insA	ENST00000265742.3	+	3	805_806	c.429_430insA	c.(427-432)aaaaaafs	p.KK143fs		NM_019004.1	NP_061877.1	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	143							protein binding|zinc ion binding	p.N146fs*12(2)		cervix(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(19)|skin(1)	41	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CTGTTGATAACAAAAAAAACAC	0.361													17	46	---	---	---	---					
MDFIC	29969	broad.mit.edu	37	7	114562639	114562641	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr7:114562639_114562641delGAG	ENST00000257724.3	+	1	431_433	c.168_170delGAG	c.(166-171)aag>aa	p.KR56del	MDFIC_ENST00000448022.1_5'UTR|MDFIC_ENST00000393486.1_5'UTR			Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing	0					activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleolus|nucleus	cyclin binding|Tat protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	8						CGGGGCggaagaggaggaggagg	0.709											OREG0003787	type=REGULATORY REGION|Gene=MDFIC|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	2	4	---	---	---	---					
AF121898.3	0	broad.mit.edu	37	8	88608731	88608731	+	RNA	DEL	T	T	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr8:88608731delT	ENST00000517711.1	-	0	232				AF121898.3_ENST00000518494.1_RNA|AF121898.3_ENST00000440763.2_RNA																							aatttttgtatttttagtaga	0.547													2	4	---	---	---	---					
RANBP6	26953	broad.mit.edu	37	9	6012690	6012690	+	Frame_Shift_Del	DEL	T	T	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr9:6012690delT	ENST00000259569.5	-	1	2928	c.2918delA	c.(2917-2919)atfs	p.N973fs		NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	973					protein transport	cytoplasm|nucleus	binding	p.N973fs*12(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		AGCAATGACATTTTTTTTGGT	0.358													9	64	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68398095	68398095	+	RNA	DEL	C	C	-	rs74487823		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr9:68398095delC	ENST00000417843.2	-	0	2660																											CCATGCTTAGCTTGGGTTTCT	0.353													4	6	---	---	---	---					
ARHGAP12	94134	broad.mit.edu	37	10	32197365	32197366	+	Frame_Shift_Ins	INS	-	-	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr10:32197365_32197366insA	ENST00000375250.5	-	3	659_660	c.418_419insT	c.(418-420)taafs	p.*140fs	ARHGAP12_ENST00000311380.4_Frame_Shift_Ins_p.*140fs|ARHGAP12_ENST00000396144.4_Frame_Shift_Ins_p.*140fs|ARHGAP12_ENST00000344936.2_Frame_Shift_Ins_p.*140fs|ARHGAP12_ENST00000375245.4_Frame_Shift_Ins_p.*140fs	NM_001270696.1	NP_001257625.1	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	140					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(11)|lung(10)|skin(1)|urinary_tract(2)	31		Prostate(175;0.0199)				ACCTTGATTATAACTGGGTCCA	0.421													57	4	---	---	---	---					
USP15	9958	broad.mit.edu	37	12	62786091	62786091	+	Frame_Shift_Del	DEL	A	A	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr12:62786091delA	ENST00000280377.5	+	18	2402	c.2344delA	c.(2344-2346)aafs	p.K783fs	USP15_ENST00000393654.3_Frame_Shift_Del_p.K758fs|USP15_ENST00000353364.3_Frame_Shift_Del_p.K754fs	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	783					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		TAAACCTCCTAAAAAACCCTT	0.303													13	0	---	---	---	---					
RHOF	54509	broad.mit.edu	37	12	122231493	122231494	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr12:122231493_122231494delCC	ENST00000267205.2	-	1	674_675	c.46_47delGG	c.(46-48)cfs	p.G16fs	RP11-347I19.3_ENST00000545544.1_RNA	NM_019034.2	NP_061907.2	Q9HBH0	RHOF_HUMAN	ras homolog family member F (in filopodia)	16					actin filament organization|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity			large_intestine(1)|lung(1)|ovary(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;4.38e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.223)		CTCCTTCCTGCCCGGACCGGGG	0.733													2	4	---	---	---	---					
LATS2	26524	broad.mit.edu	37	13	21562146	21562147	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr13:21562146_21562147delCT	ENST00000382592.4	-	4	2177_2178	c.1772_1773delAG	c.(1771-1773)gfs	p.E591fs	LATS2_ENST00000542899.1_Frame_Shift_Del_p.E591fs	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	591					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		TGATGCGTGACTCTCTCTTCTC	0.515													89	105	---	---	---	---					
RP11-146E13.4	0	broad.mit.edu	37	14	19858136	19858136	+	RNA	DEL	G	G	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:19858136delG	ENST00000548109.1	+	0	72																											gctcaatgttggggcaaagtg	0.413													2	4	---	---	---	---					
RP11-349A22.5	0	broad.mit.edu	37	14	58752231	58752231	+	RNA	DEL	T	T	-	rs74576640		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:58752231delT	ENST00000554360.1	-	0	414				RP11-349A22.5_ENST00000553657.1_RNA|RP11-349A22.5_ENST00000556400.1_RNA|RP11-349A22.5_ENST00000556002.1_RNA|RP11-349A22.5_ENST00000555707.1_RNA|RP11-349A22.5_ENST00000555275.1_RNA|RP11-349A22.5_ENST00000554378.1_RNA|RP11-349A22.5_ENST00000557660.1_RNA	NR_029434.1																						GTACAGTGTCTTTTTTTGTAT	0.353													5	10	---	---	---	---					
EXOC3L4	91828	broad.mit.edu	37	14	103568742	103568742	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:103568742delC	ENST00000380069.3	+	2	758	c.682delC	c.(682-684)ccfs	p.P229fs		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	229										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						CCACCCTTCTCCCCCCGACGA	0.771													4	5	---	---	---	---					
TMEM121	80757	broad.mit.edu	37	14	105996050	105996052	+	In_Frame_Del	DEL	GCC	GCC	-	rs5811180		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr14:105996050_105996052delGCC	ENST00000392519.2	+	2	1043_1045	c.879_881delGCC	c.(877-882)gtg>gt	p.VP293del	TMEM121_ENST00000431372.1_In_Frame_Del_p.VP293del	NM_025268.2	NP_079544.1	Q9BTD3	TM121_HUMAN	transmembrane protein 121	293	Pro-rich.					integral to membrane				endometrium(2)|lung(1)	3		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.0959)|all cancers(159;0.235)		GCAACTCGGTgccgccgccgccg	0.768													4	3	---	---	---	---					
LTK	4058	broad.mit.edu	37	15	41796335	41796336	+	Frame_Shift_Ins	INS	-	-	G			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr15:41796335_41796336insG	ENST00000263800.6	-	20	2549_2550	c.2453_2454insC	c.(2452-2454)ccafs	p.P818fs	LTK_ENST00000355166.5_Frame_Shift_Ins_p.P757fs|LTK_ENST00000561619.1_Frame_Shift_Ins_p.P516fs|LTK_ENST00000453182.2_Frame_Shift_Ins_p.P688fs	NM_002344.5	NP_002335.2	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase	818					apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		CCTGGGGCTGTGGGGGTCTTAG	0.604										TSP Lung(18;0.14)			20	20	---	---	---	---					
PTX4	390667	broad.mit.edu	37	16	1536186	1536186	+	Frame_Shift_Del	DEL	G	G	-	rs148668779		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:1536186delG	ENST00000447419.2	-	3	1216	c.1191delC	c.(1189-1191)ccfs	p.P397fs	PTX4_ENST00000440447.2_3'UTR|PTX4_ENST00000293922.1_Frame_Shift_Del_p.P392fs			Q96A99	PTX4_HUMAN	pentraxin 4, long	397	Pentaxin.					extracellular region	metal ion binding	p.G393fs*57(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17						GGGACCCTCCGGGGGGGATCT	0.667													30	47	---	---	---	---					
RP11-439I14.2	0	broad.mit.edu	37	16	64770704	64770705	+	RNA	INS	-	-	CCAGTGATGGTCACCT	rs140029302	by1000genomes	TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr16:64770704_64770705insCCAGTGATGGTCACCT	ENST00000564293.1	+	0	453_454																											TGTCACCACTGCCACCTTGTTC	0.371													3	2	---	---	---	---					
SMARCA4	6597	broad.mit.edu	37	19	11141533	11141534	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:11141533_11141534delTG	ENST00000358026.2	+	25	3794_3795	c.3510_3511delTG	c.(3508-3513)actgfs	p.TV1170fs	SMARCA4_ENST00000590574.1_Frame_Shift_Del_p.TV1170fs|SMARCA4_ENST00000541122.2_Frame_Shift_Del_p.TV1170fs|SMARCA4_ENST00000429416.3_Frame_Shift_Del_p.TV1170fs|SMARCA4_ENST00000444061.3_Frame_Shift_Del_p.TV1170fs|SMARCA4_ENST00000450717.3_Frame_Shift_Del_p.TV1170fs|SMARCA4_ENST00000589677.1_Frame_Shift_Del_p.TV1170fs|SMARCA4_ENST00000344626.4_Frame_Shift_Del_p.TV1170fs|SMARCA4_ENST00000413806.3_Frame_Shift_Del_p.TV1170fs	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1170	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CGGCAGACACTGTGATCATTTT	0.599			"""F, N, Mis"""		NSCLC								9	1	---	---	---	---					
MYBPC2	4606	broad.mit.edu	37	19	50963425	50963425	+	Frame_Shift_Del	DEL	A	A	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:50963425delA	ENST00000357701.5	+	24	2971	c.2920delA	c.(2920-2922)aafs	p.K975fs		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	975	Fibronectin type-III 3.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GAAAGCAGACAAAAAAACCAT	0.592													7	23	---	---	---	---					
FPR3	2359	broad.mit.edu	37	19	52327267	52327267	+	Frame_Shift_Del	DEL	A	A	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr19:52327267delA	ENST00000339223.4	+	2	445	c.266delA	c.(265-267)gafs	p.E89fs	FPR3_ENST00000595991.1_Frame_Shift_Del_p.E89fs	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	89					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						GCCATGAGAGAAAAATGGCCT	0.458													56	231	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11066363	11066363	+	RNA	DEL	T	T	-	rs151040810		TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr21:11066363delT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		agaggttaaatttccttgttc	0.294													3	6	---	---	---	---					
PFKL	5211	broad.mit.edu	37	21	45733884	45733885	+	Frame_Shift_Ins	INS	-	-	TG			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr21:45733884_45733885insTG	ENST00000403390.1	+	8	868_869	c.868_869insTG	c.(868-870)gtgfs	p.V290fs	PFKL_ENST00000496824.1_3'UTR|PFKL_ENST00000349048.4_Frame_Shift_Ins_p.V243fs			P17858	K6PL_HUMAN	phosphofructokinase, liver	243					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		GGAGAACTTCATGTGTGAGAGG	0.668													15	10	---	---	---	---					
MICAL3	57553	broad.mit.edu	37	22	18324556	18324556	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chr22:18324556delC	ENST00000414725.2	-	20	2916	c.2917delG	c.(2917-2919)ccfs	p.A973fs	MICAL3_ENST00000383094.3_Frame_Shift_Del_p.A945fs|MICAL3_ENST00000444520.1_Intron|MICAL3_ENST00000400561.2_Intron|MICAL3_ENST00000441493.2_Intron|MICAL3_ENST00000207726.7_Frame_Shift_Del_p.A973fs			Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	0	Glu-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		ggccgtgtggcgggtGGGCGC	0.662													2	4	---	---	---	---					
YY2	404281	broad.mit.edu	37	X	21875706	21875707	+	Frame_Shift_Ins	INS	-	-	A			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:21875706_21875707insA	ENST00000429584.2	+	1	1602_1603	c.1104_1105insA	c.(1102-1107)acaaaafs	p.TK368fs	MBTPS2_ENST00000365779.2_Intron|MBTPS2_ENST00000379484.5_Intron|MBTPS2_ENST00000465888.1_3'UTR	NM_206923.3	NP_996806.2	O15391	TYY2_HUMAN	YY2 transcription factor	368	Mediates transcriptional repression.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(2)	19						ATGTGAAGACCAAAAACAACCC	0.470													117	165	---	---	---	---					
AMOT	154796	broad.mit.edu	37	X	112035202	112035202	+	Frame_Shift_Del	DEL	T	T	-			TCGA-NA-A4R1-01A-11D-A28R-08	TCGA-NA-A4R1-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7b5cd9f8-2ef3-4705-871d-9ca861e99a17	dd776c35-4bb8-48e6-a6d6-66963175fafa	g.chrX:112035202delT	ENST00000371959.3	-	6	1783	c.1784delA	c.(1783-1785)agfs	p.K596fs	AMOT_ENST00000371958.1_Frame_Shift_Del_p.K364fs|AMOT_ENST00000304758.1_Frame_Shift_Del_p.K187fs|AMOT_ENST00000524145.1_Frame_Shift_Del_p.K596fs|AMOT_ENST00000371962.1_Frame_Shift_Del_p.K364fs	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	596					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						CACTTGCTTCTTTTTCAGCTG	0.473													18	68	---	---	---	---					
