Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PRAMEF10	343071	broad.mit.edu	37	1	12955542	12955542	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:12955542A>C	uc001auo.2	-	2	210	c.137T>G	c.(136-138)ATG>AGG	p.M46R		NM_001039361	NP_001034450	O60809	PRA10_HUMAN	PRAME family member 10	46											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AAAACGTCTCATGCTGAAGGC	0.572													33	21					0	0	0	0
DDI2	84301	broad.mit.edu	37	1	15956910	15956910	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:15956910C>T	uc001awx.1	+	3	455	c.359C>T	c.(358-360)TCA>TTA	p.S120L	DDI2_uc001aww.2_Missense_Mutation_p.S120L|DDI2_uc009voj.1_5'UTR	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	120					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		CAGTCCCACTCATCTCCTGGA	0.542													33	15					0	0	0	0
CLCNKA	1187	broad.mit.edu	37	1	16358311	16358311	+	Missense_Mutation	SNP	A	G	G	rs139001368		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:16358311A>G	uc001axu.2	+	16	1809	c.1729A>G	c.(1729-1731)ACC>GCC	p.T577A	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Missense_Mutation_p.T577A|CLCNKA_uc010obw.1_Missense_Mutation_p.T534A|CLCNKB_uc001axw.3_Intron|CLCNKA_uc010oby.1_Intron	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	577	CBS 1.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	CACAGACGTGACCGAGTATCC	0.582													4	41					0	0	0	0
CLCNKB	1188	broad.mit.edu	37	1	16380200	16380200	+	Silent	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:16380200A>G	uc001axw.3	+	16	1769	c.1689A>G	c.(1687-1689)CCA>CCG	p.P563P	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Silent_p.P563P|CLCNKB_uc001axy.3_Silent_p.P394P	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	563	CBS 1.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		AGGACATGCCACTGGAGGAGG	0.632													15	15					0	0	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418													6	66					0	0	0	0
CROCCL1	84809	broad.mit.edu	37	1	16945358	16945358	+	RNA	SNP	G	C	C	rs945905	by1000genomes	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:16945358G>C	uc010ocf.1	-	4		c.799C>G			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						AGTAGGAGAAGAGAGAGGAAG	0.567													6	8					0	0	0	0
PABPC4	8761	broad.mit.edu	37	1	40030930	40030930	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:40030930C>A	uc010oiv.1	-	8	1991	c.1093G>T	c.(1093-1095)GTT>TTT	p.V365F	PABPC4_uc001cdl.2_Missense_Mutation_p.V365F|PABPC4_uc001cdm.2_Missense_Mutation_p.V365F	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	365	RRM 4.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GCCAGGGCAACATATAGTGGC	0.507													30	17					8.4185e-14	1.17529e-13	1	0
STIL	6491	broad.mit.edu	37	1	47717390	47717390	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:47717390G>A	uc001crc.1	-	17	3437	c.3282C>T	c.(3280-3282)AGC>AGT	p.S1094S	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Silent_p.S1048S|STIL_uc010omo.1_Silent_p.S1077S|STIL_uc001crd.1_Silent_p.S1095S|STIL_uc001cre.1_Silent_p.S1094S	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	1094					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TATGGAGAAGGCTGAATGGGT	0.373													69	42					0	0	0	0
C1orf83	127428	broad.mit.edu	37	1	54562036	54562036	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:54562036C>T	uc001cwt.1	+	5	717	c.517C>T	c.(517-519)CGG>TGG	p.R173W	C1orf83_uc001cwu.1_RNA	NM_153035	NP_694580	Q96MN5	TEAN2_HUMAN	hypothetical protein LOC127428	173	TFIIS central.				transcription, DNA-dependent	nucleus	DNA binding				0						GCCGTACCGGCGGACGGTGAG	0.512													38	20					0	0	0	0
LEPR	3953	broad.mit.edu	37	1	66081724	66081724	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:66081724C>T	uc001dci.2	+	15	2231	c.2029C>T	c.(2029-2031)CAG>TAG	p.Q677*	LEPR_uc001dcg.2_Nonsense_Mutation_p.Q677*|LEPR_uc001dch.2_Nonsense_Mutation_p.Q677*|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Nonsense_Mutation_p.Q677*|LEPR_uc001dck.2_Nonsense_Mutation_p.Q677*	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	677	Extracellular (Potential).|Fibronectin type-III 3.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GTGCAGTGTTCAGAGATATGT	0.393													15	15					0	0	0	0
C1orf173	127254	broad.mit.edu	37	1	75037100	75037100	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:75037100C>A	uc001dgg.2	-	14	4513	c.4294G>T	c.(4294-4296)GGC>TGC	p.G1432C		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1432	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCTGGAGTGCCCACCCCAGCC	0.612													58	33					2.43698e-19	3.69176e-19	1	0
AGL	178	broad.mit.edu	37	1	100327061	100327061	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:100327061T>C	uc001dsi.1	+	3	485	c.85T>C	c.(85-87)TAT>CAT	p.Y29H	AGL_uc001dsj.1_Missense_Mutation_p.Y29H|AGL_uc001dsk.1_Missense_Mutation_p.Y29H|AGL_uc001dsl.1_Missense_Mutation_p.Y29H|AGL_uc001dsm.1_Missense_Mutation_p.Y13H|AGL_uc001dsn.1_Missense_Mutation_p.Y12H	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	29	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TTATTTAGGGTATGAGCTACA	0.308													12	9					0	0	0	0
MAGI3	260425	broad.mit.edu	37	1	114216018	114216018	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:114216018G>A	uc001edk.2	+	19	3301	c.3120G>A	c.(3118-3120)GAG>GAA	p.E1040E	MAGI3_uc001edh.3_Silent_p.E1065E|MAGI3_uc001edi.3_Silent_p.E1040E|MAGI3_uc010owm.1_Silent_p.E1065E|MAGI3_uc001edj.2_Silent_p.E761E	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1065	PDZ 6.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGGGAAGGAGTACAACATGG	0.488													64	39					0	0	0	0
MTMR11	10903	broad.mit.edu	37	1	149905389	149905389	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:149905389C>T	uc001etl.3	-	10	1146	c.895G>A	c.(895-897)GAT>AAT	p.D299N	MTMR11_uc001etm.1_Missense_Mutation_p.D227N|MTMR11_uc010pbm.1_Missense_Mutation_p.D271N|MTMR11_uc010pbn.1_Missense_Mutation_p.D141N	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	299	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			AGGACAACATCTGAATGCCCA	0.547													31	105					0	0	0	0
RFX5	5993	broad.mit.edu	37	1	151315026	151315026	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:151315026G>C	uc001exv.1	-	11	1701	c.1487C>G	c.(1486-1488)TCA>TGA	p.S496*	RFX5_uc001exw.1_Nonsense_Mutation_p.S496*|RFX5_uc009wmr.1_Nonsense_Mutation_p.S496*|RFX5_uc010pcx.1_Nonsense_Mutation_p.S456*	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5	496						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGGTAACCTTGAGGACTGGGC	0.577													83	194					0	0	0	0
NUP210L	91181	broad.mit.edu	37	1	154034118	154034118	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:154034118C>T	uc001fdw.2	-	18	2659	c.2587G>A	c.(2587-2589)GGG>AGG	p.G863R	NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Missense_Mutation_p.G863R	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	863						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AGTACAGTCCCTTTTATCTGA	0.338													27	53					0	0	0	0
KIAA0907	22889	broad.mit.edu	37	1	155887393	155887393	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:155887393T>G	uc001fmi.1	-	11	1361	c.1337A>C	c.(1336-1338)CAG>CCG	p.Q446P	KIAA0907_uc001fmj.1_Missense_Mutation_p.Q446P|KIAA0907_uc009wrk.1_Missense_Mutation_p.Q303P|KIAA0907_uc009wrl.1_RNA	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	446	Pro-rich.										0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			gggctggggctggggctgggg	0.448													9	35					0	0	0	0
OR6K2	81448	broad.mit.edu	37	1	158669597	158669597	+	Missense_Mutation	SNP	C	G	G	rs141159720	byFrequency	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:158669597C>G	uc001fsu.1	-	1	846	c.846G>C	c.(844-846)TTG>TTC	p.L282F		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AGAAGGGAGACAAAACTGCAA	0.403													10	29					0	0	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161022564	161022564	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:161022564G>A	uc001fxl.2	-	7	1034	c.688C>T	c.(688-690)CGA>TGA	p.R230*	ARHGAP30_uc001fxk.2_Nonsense_Mutation_p.R230*|ARHGAP30_uc001fxm.2_Nonsense_Mutation_p.R76*|ARHGAP30_uc009wtx.2_5'UTR|ARHGAP30_uc001fxn.1_Nonsense_Mutation_p.R76*	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	230					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GGAAGCGATCGCCACCCACTC	0.607													27	39					0	0	0	0
DUSP12	11266	broad.mit.edu	37	1	161719654	161719654	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:161719654C>T	uc001gbo.2	+	1	74	c.63C>T	c.(61-63)GTC>GTT	p.V21V	DUSP12_uc001gbp.2_5'UTR	NM_007240	NP_009171	Q9UNI6	DUS12_HUMAN	dual specificity phosphatase 12	21					positive regulation of glucokinase activity	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding			breast(1)	1	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			CCAGCAGAGTCAGCTGTGCCG	0.672													4	16					0	0	0	0
C1orf114	57821	broad.mit.edu	37	1	169390813	169390813	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:169390813C>T	uc001gga.1	-	3	1024	c.856G>A	c.(856-858)GAG>AAG	p.E286K	C1orf114_uc001gfz.1_Missense_Mutation_p.E286K|C1orf114_uc009wvq.1_Missense_Mutation_p.E286K|C1orf114_uc001ggb.2_Missense_Mutation_p.E286K|C1orf114_uc001ggc.1_Missense_Mutation_p.E286K	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	286											0	all_hematologic(923;0.208)					GCCAGCGGCTCTCCTGTTGAT	0.473													53	142					0	0	0	0
PRRX1	5396	broad.mit.edu	37	1	170688866	170688866	+	Splice_Site	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:170688866G>C	uc001ghf.2	+	2	289	c.242_splice	c.e2-1	p.N81_splice	PRRX1_uc001ghe.2_Splice_Site_p.N81_splice	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTCTATTCCAGATGACCAGCT	0.408													14	19					0	0	0	0
BAT2L2	23215	broad.mit.edu	37	1	171509618	171509618	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:171509618G>T	uc010pmg.1	+	16	3273	c.3007G>T	c.(3007-3009)GAA>TAA	p.E1003*	BAT2L2_uc010pmh.1_5'UTR	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	1003							protein C-terminus binding				0						TAACAGAAGGGAAGAAGTTAA	0.413													17	16					1.02788e-11	1.39136e-11	1	0
CACNA1E	777	broad.mit.edu	37	1	181680164	181680164	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:181680164A>G	uc001gow.2	+	8	1295	c.1130A>G	c.(1129-1131)GAG>GGG	p.E377G	CACNA1E_uc009wxs.2_Missense_Mutation_p.E284G	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	377	Cytoplasmic (Potential).|Binding to the beta subunit (By similarity).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CAGCAGATTGAGCGTGAGCTG	0.577													39	98					0	0	0	0
IVNS1ABP	10625	broad.mit.edu	37	1	185276680	185276680	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:185276680G>C	uc001grl.2	-	6	1095	c.472C>G	c.(472-474)CAG>GAG	p.Q158E	IVNS1ABP_uc001grj.2_5'Flank|IVNS1ABP_uc009wyj.2_5'UTR|IVNS1ABP_uc009wyk.2_RNA	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	158	BACK.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						AAATGCTCCTGAATATAAGCA	0.363													25	70					0	0	0	0
HMCN1	83872	broad.mit.edu	37	1	185946936	185946936	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:185946936C>T	uc001grq.1	+	16	2618	c.2389C>T	c.(2389-2391)CAA>TAA	p.Q797*	HMCN1_uc001grr.1_Nonsense_Mutation_p.Q138*	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	797	Ig-like C2-type 5.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AGTTTTCATACAAGAACCTGC	0.343													49	61					0	0	0	0
PRELP	5549	broad.mit.edu	37	1	203452824	203452824	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:203452824G>A	uc001gzs.2	+	2	712	c.512G>A	c.(511-513)CGG>CAG	p.R171Q	PRELP_uc001gzt.2_Missense_Mutation_p.R171Q	NM_002725	NP_002716	P51888	PRELP_HUMAN	proline arginine-rich end leucine-rich repeat	171	LRR 4.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(1)|central_nervous_system(1)|pancreas(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.109)			GCCCTGCCCCGGAACCTGGAG	0.597													5	149					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237660034	237660034	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:237660034G>C	uc001hyl.1	+	20	2305	c.2185G>C	c.(2185-2187)GGC>CGC	p.G729R		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	729	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGGATTTGATGGCCTTCATCT	0.493													65	188					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237865319	237865319	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:237865319T>A	uc001hyl.1	+	66	9529	c.9409T>A	c.(9409-9411)TTA>ATA	p.L3137I	RYR2_uc010pxz.1_Missense_Mutation_p.L92I	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3137					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCTGACTAGCTTATATGCTTT	0.328													32	16					0	0	0	0
FMN2	56776	broad.mit.edu	37	1	240370643	240370643	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:240370643C>T	uc010pyd.1	+	5	2756	c.2531C>T	c.(2530-2532)TCT>TTT	p.S844F	FMN2_uc010pye.1_Missense_Mutation_p.S848F	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	844	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CACGAACACTCTGTTTCCTCT	0.562													73	68					0	0	0	0
RGS7	6000	broad.mit.edu	37	1	240964780	240964780	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:240964780G>C	uc001hyv.2	-	17	1718	c.1388C>G	c.(1387-1389)TCT>TGT	p.S463C	RGS7_uc010pyh.1_Intron|RGS7_uc010pyj.1_Intron|RGS7_uc001hyu.2_Intron|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Intron|RGS7_uc001hyt.2_Missense_Mutation_p.S295C	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	463					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TTTTTCAAAAGATGTTCTGCG	0.239													10	18					0	0	0	0
KIF26B	55083	broad.mit.edu	37	1	245849620	245849620	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:245849620G>T	uc001ibf.1	+	12	3775	c.3335G>T	c.(3334-3336)GGC>GTC	p.G1112V	KIF26B_uc001ibg.1_Missense_Mutation_p.G730V|KIF26B_uc001ibh.1_Missense_Mutation_p.G354V	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1112					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AAGGATTCCGGCGTGGCGTCT	0.612													56	125					3.31993e-32	5.42153e-32	1	0
OR2T1	26696	broad.mit.edu	37	1	248569514	248569514	+	Silent	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:248569514C>A	uc010pzm.1	+	1	219	c.219C>A	c.(217-219)ACC>ACA	p.T73T		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	73	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GAAAGGAAACCTCAGGTCTTA	0.423													83	73					1.20873e-29	1.9471e-29	1	0
OR2T3	343173	broad.mit.edu	37	1	248637225	248637225	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:248637225C>T	uc001iel.1	+	1	574	c.574C>T	c.(574-576)CTC>TTC	p.L192F		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCTGCTGAAGCTCTCCTGCTC	0.517													192	155					0	0	0	0
OR2T3	343173	broad.mit.edu	37	1	248637239	248637239	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:248637239C>G	uc001iel.1	+	1	588	c.588C>G	c.(586-588)GAC>GAG	p.D196E		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCTGCTCTGACGTCTCCCTCT	0.522													107	273					0	0	0	0
FAM188A	80013	broad.mit.edu	37	10	15828592	15828592	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:15828592C>A	uc001iod.1	-	13	1305	c.1084G>T	c.(1084-1086)GGC>TGC	p.G362C	FAM188A_uc001ioe.1_Missense_Mutation_p.G189C	NM_024948	NP_079224	Q9H8M7	F188A_HUMAN	chromosome 10 open reading frame 97	362					apoptosis	nucleus	calcium ion binding			ovary(1)	1						AGAAATGGGCCCAATAATATG	0.338													38	77					6.97489e-18	1.03032e-17	1	0
KIAA1217	56243	broad.mit.edu	37	10	24727394	24727394	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:24727394A>G	uc001iru.3	+	5	1235	c.832A>G	c.(832-834)AAT>GAT	p.N278D	KIAA1217_uc001irs.2_Missense_Mutation_p.N198D|KIAA1217_uc001irt.3_Missense_Mutation_p.N278D|KIAA1217_uc010qcy.1_Missense_Mutation_p.N278D|KIAA1217_uc010qcz.1_Missense_Mutation_p.N278D|KIAA1217_uc001irv.1_Missense_Mutation_p.N128D|KIAA1217_uc010qda.1_RNA	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	278					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						AAAAACTATGAATGGAGACAT	0.403													43	56					0	0	0	0
ZNF37B	100129482	broad.mit.edu	37	10	43015849	43015849	+	RNA	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:43015849G>A	uc001jab.3	-	5		c.3351C>T			ZNF37B_uc001jac.3_RNA|ZNF37B_uc001jaa.3_RNA					Homo sapiens cDNA: FLJ23327 fis, clone HEP12630, highly similar to HSZNF37 Homo sapiens ZNF37A mRNA for zinc finger protein.												0						TCTCTCCCCTGTGTGAATTCT	0.413													16	27					0	0	0	0
PPYR1	5540	broad.mit.edu	37	10	47087602	47087602	+	Silent	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:47087602C>A	uc001jee.2	+	3	1238	c.819C>A	c.(817-819)GCC>GCA	p.A273A	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Silent_p.A273A	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	273	Helical; Name=6; (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						TGGTGGTGGCCTTTGCTGTGC	0.587													20	87					3.99206e-14	5.59517e-14	1	0
LOC642826	642826	broad.mit.edu	37	10	47207813	47207813	+	RNA	SNP	T	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:47207813T>C	uc001jei.2	-	12		c.1586A>G			uc009xnf.2_Missense_Mutation_p.H132R					Homo sapiens cDNA, FLJ99065.												0						TTTACTTACATGGTTTGTACA	0.294													4	20					0	0	0	0
OGDHL	55753	broad.mit.edu	37	10	50945898	50945898	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:50945898T>A	uc001jie.2	-	20	2666	c.2524A>T	c.(2524-2526)ATC>TTC	p.I842F	OGDHL_uc009xog.2_Missense_Mutation_p.I869F|OGDHL_uc010qgt.1_Missense_Mutation_p.I785F|OGDHL_uc010qgu.1_Missense_Mutation_p.I633F	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	842					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GGTGTGAAGATAATCAGCTGG	0.617													33	50					0	0	0	0
PCDH15	65217	broad.mit.edu	37	10	56106133	56106133	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:56106133C>A	uc001jju.1	-	6	981	c.586G>T	c.(586-588)GAT>TAT	p.D196Y	PCDH15_uc010qhq.1_Missense_Mutation_p.D201Y|PCDH15_uc010qhr.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhs.1_Missense_Mutation_p.D201Y|PCDH15_uc010qht.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhu.1_Missense_Mutation_p.D196Y|PCDH15_uc001jjv.1_Missense_Mutation_p.D174Y|PCDH15_uc010qhv.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhw.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhx.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhy.1_Missense_Mutation_p.D201Y|PCDH15_uc010qhz.1_Missense_Mutation_p.D196Y|PCDH15_uc010qia.1_Missense_Mutation_p.D174Y|PCDH15_uc010qib.1_Missense_Mutation_p.D174Y|PCDH15_uc001jjw.2_Missense_Mutation_p.D196Y	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	196	Extracellular (Potential).|Cadherin 2.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACCGGATCATCTGGATTATAC	0.308										HNSCC(58;0.16)			26	59					1.66031e-10	2.21374e-10	1	0
GLUD1	2746	broad.mit.edu	37	10	88836358	88836358	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:88836358C>T	uc001keh.2	-	2	598	c.501G>A	c.(499-501)CTG>CTA	p.L167L	GLUD1_uc001keg.2_5'UTR|GLUD1_uc010qmp.1_Silent_p.L34L	NM_005271	NP_005262	P00367	DHE3_HUMAN	glutamate dehydrogenase 1 precursor	167					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding				0					L-Glutamic Acid(DB00142)|NADH(DB00157)	TGTATGTCATCAGAGAAGCCA	0.413													25	36					0	0	0	0
PKD2L1	9033	broad.mit.edu	37	10	102050202	102050202	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:102050202C>A	uc001kqx.1	-	13	2465	c.2082G>T	c.(2080-2082)GAG>GAT	p.E694D	PKD2L1_uc009xwm.1_Missense_Mutation_p.E647D	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	694	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		CTCTGGCAGCCTCTGGACCCG	0.527													8	23					0.000157383	0.000191878	1	0
WNT8B	7479	broad.mit.edu	37	10	102241771	102241771	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:102241771G>A	uc001krb.2	+	5	584	c.470G>A	c.(469-471)CGG>CAG	p.R157Q		NM_003393	NP_003384	Q93098	WNT8B_HUMAN	wingless-type MMTV integration site family,	157					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|determination of dorsal identity|endoderm development|eye development|gastrulation|hypothalamus development|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway|otic placode formation|positive regulation of gene expression|response to estradiol stimulus|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			ovary(1)|breast(1)|large_intestine(1)|skin(1)	4		Colorectal(252;0.117)		Epithelial(162;1.87e-10)|all cancers(201;1.64e-08)		CAGGATGCACGGGCAGCCATG	0.592											OREG0020440	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	48					0	0	0	0
C10orf79	80217	broad.mit.edu	37	10	105893540	105893540	+	Silent	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr10:105893540A>G	uc001kxw.2	-	35	4550	c.4434T>C	c.(4432-4434)ACT>ACC	p.T1478T	C10orf79_uc009xxq.2_Silent_p.T757T	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	1478											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TTTGTCCTTGAGTCTTTAAAA	0.318													15	31					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1263788	1263788	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:1263788C>A	uc009ycr.1	+	47	7883	c.7757C>A	c.(7756-7758)TCC>TAC	p.S2586Y	MUC5B_uc001ltb.2_Missense_Mutation_p.S1896Y	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1893	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCCACCAGCTCCACGGCCACG	0.612													45	81					1.86633e-21	2.88876e-21	1	0
OR52L1	338751	broad.mit.edu	37	11	6007529	6007529	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:6007529G>T	uc001mcd.2	-	1	687	c.632C>A	c.(631-633)ACA>AAA	p.T211K		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	211	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCGATTGACTGTGGTTTCTGA	0.493													55	99					5.22555e-25	8.19514e-25	1	0
DCHS1	8642	broad.mit.edu	37	11	6643935	6643935	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:6643935C>T	uc001mem.1	-	21	9382	c.8972G>A	c.(8971-8973)CGG>CAG	p.R2991Q		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	2991	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGTGGCTCCCGGCCCAGTTT	0.642													5	5					0	0	0	0
OR5P2	120065	broad.mit.edu	37	11	7818034	7818034	+	Silent	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:7818034A>G	uc001mfp.1	-	1	456	c.456T>C	c.(454-456)GCT>GCC	p.A152A		NM_153444	NP_703145	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TATAGGAGACAGCAATGAGAA	0.388													31	44					0	0	0	0
ST5	6764	broad.mit.edu	37	11	8737301	8737301	+	Missense_Mutation	SNP	C	T	T	rs35353984		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:8737301C>T	uc001mgt.2	-	6	1880	c.1694G>A	c.(1693-1695)CGG>CAG	p.R565Q	ST5_uc009yfr.2_Missense_Mutation_p.R145Q|ST5_uc001mgu.2_Missense_Mutation_p.R145Q|ST5_uc001mgv.2_Missense_Mutation_p.R565Q|ST5_uc010rbq.1_RNA|ST5_uc010rbp.1_Missense_Mutation_p.R78Q	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	565					positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		TCGTGGCAGCCGGTGGCTCTT	0.617													41	80					0	0	0	0
ANO5	203859	broad.mit.edu	37	11	22301128	22301128	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:22301128G>T	uc001mqi.2	+	22	2876	c.2559G>T	c.(2557-2559)ATG>ATT	p.M853I	ANO5_uc001mqj.2_Missense_Mutation_p.M852I	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	853	Helical; (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TGGCCTGGATGATACCTGATG	0.358													17	37					0.00074312	0.000899833	1	0
LRP4	4038	broad.mit.edu	37	11	46908046	46908046	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:46908046T>C	uc001ndn.3	-	17	2400	c.2254A>G	c.(2254-2256)ATC>GTC	p.I752V		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	752	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		ATTCGACGGATGTCCATCCTT	0.517													25	34					0	0	0	0
OR4X2	119764	broad.mit.edu	37	11	48267430	48267430	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:48267430A>G	uc001ngs.1	+	1	775	c.775A>G	c.(775-777)ATA>GTA	p.I259V		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	259	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CACTCTGCCCATAGACAAGAT	0.512													26	32					0	0	0	0
OR4A47	403253	broad.mit.edu	37	11	48511249	48511249	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:48511249G>T	uc010rhx.1	+	1	905	c.905G>T	c.(904-906)AGA>ATA	p.R302I		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTCTGGAGAAGAGACCTCATA	0.413													28	50					1.77063e-15	2.54171e-15	1	0
OR4C46	119749	broad.mit.edu	37	11	51515722	51515722	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:51515722G>T	uc010ric.1	+	1	441	c.441G>T	c.(439-441)TGG>TGT	p.W147C		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GAGTGGTGTGGATGGGAGGCT	0.463													75	119					1.15098e-32	1.88824e-32	1	0
OR5T3	390154	broad.mit.edu	37	11	56019812	56019812	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:56019812G>C	uc010rjd.1	+	1	137	c.137G>C	c.(136-138)GGC>GCC	p.G46A		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	46	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					ATATTGACAGGCTTCACAGAT	0.373													41	67					0	0	0	0
OR5M1	390168	broad.mit.edu	37	11	56380788	56380788	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:56380788C>T	uc001nja.1	-	1	191	c.191G>A	c.(190-192)GGC>GAC	p.G64D		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GGAGAGGTGGCCAAGGAAGAA	0.468													44	80					0	0	0	0
ACY3	91703	broad.mit.edu	37	11	67410230	67410230	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:67410230G>T	uc001omq.2	-	8	1096	c.925C>A	c.(925-927)CCC>ACC	p.P309T		NM_080658	NP_542389	Q96HD9	ACY3_HUMAN	aspartoacylase 3	309					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	GTCAGCGCGGGCATGGCAGGC	0.587													45	98					4.78724e-31	7.782e-31	1	0
LRP5	4041	broad.mit.edu	37	11	68154175	68154175	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:68154175G>A	uc001ont.2	+	6	1482	c.1407G>A	c.(1405-1407)GTG>GTA	p.V469V	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	469	LDL-receptor class B 7.|Beta-propeller 2.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						TGCACCCCGTGATGGGGTAAG	0.672													13	27					0	0	0	0
P2RY2	5029	broad.mit.edu	37	11	72946311	72946311	+	Missense_Mutation	SNP	C	G	G	rs145119561	by1000genomes	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:72946311C>G	uc001otj.2	+	3	1440	c.1107C>G	c.(1105-1107)AGC>AGG	p.S369R	P2RY2_uc001otk.2_Missense_Mutation_p.S369R|P2RY2_uc001otl.2_Missense_Mutation_p.S369R	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	369	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	CGGCTGGTAGCGAGAACACTA	0.552													47	35					0	0	0	0
RELT	84957	broad.mit.edu	37	11	73101965	73101965	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:73101965G>T	uc001otv.2	+	4	451	c.286G>T	c.(286-288)GGG>TGG	p.G96W	RELT_uc001otw.2_Missense_Mutation_p.G96W|RELT_uc009yto.1_Missense_Mutation_p.G14W|RELT_uc001otx.2_5'Flank	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	96	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						CTGCTGGCCTGGGTAAGCCAA	0.602													24	19					1.77063e-15	2.54171e-15	1	0
OR2AT4	341152	broad.mit.edu	37	11	74800246	74800246	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:74800246C>G	uc010rro.1	-	1	513	c.513G>C	c.(511-513)ATG>ATC	p.M171I		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGTTATATGCCATCTGGGAGG	0.572													25	9					0	0	0	0
MYO7A	4647	broad.mit.edu	37	11	76916513	76916513	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:76916513C>T	uc001oyb.2	+	40	5759	c.5487C>T	c.(5485-5487)AGC>AGT	p.S1829S	MYO7A_uc001oyc.2_Silent_p.S1791S|MYO7A_uc001oye.2_Intron	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	1829	MyTH4 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						GCAGGTACAGCGAGGAGCGGG	0.677													5	0					0	0	0	0
MMP13	4322	broad.mit.edu	37	11	102818711	102818711	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:102818711C>G	uc001phl.2	-	8	1148	c.1120G>C	c.(1120-1122)GGT>CGT	p.G374R		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	374	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		TTTGGAAGACCCAGTTCAGAT	0.403													21	13					0	0	0	0
GRIA4	2893	broad.mit.edu	37	11	105789531	105789531	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:105789531G>C	uc001pix.2	+	11	1809	c.1363G>C	c.(1363-1365)GCA>CCA	p.A455P	GRIA4_uc001piw.2_Missense_Mutation_p.A455P	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	455	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ATCTGAAATTGCAAAACATAT	0.353													13	5					0	0	0	0
PRB2	653247	broad.mit.edu	37	12	11546873	11546873	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:11546873G>T	uc010shk.1	-	3	174	c.139C>A	c.(139-141)CCT>ACT	p.P47T		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGACCTTGAGGTTTGTTGCCT	0.537													144	181					2.60356e-62	4.39273e-62	1	0
FAM60A	58516	broad.mit.edu	37	12	31435799	31435799	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:31435799C>T	uc010sjz.1	-	6	752	c.513G>A	c.(511-513)AAG>AAA	p.K171K	FAM60A_uc001rkd.2_Silent_p.K171K|FAM60A_uc010ska.1_Silent_p.K171K|FAM60A_uc001rke.2_Silent_p.K171K|FAM60A_uc010skb.1_RNA|FAM60A_uc001rkc.2_Silent_p.K196K	NM_021238	NP_067061	Q9NP50	FA60A_HUMAN	family with sequence similarity 60, member A	171											0	all_cancers(9;5.22e-13)|all_epithelial(9;4e-13)|all_lung(12;1.2e-11)|Lung NSC(12;2.17e-09)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0207)|Lung SC(12;0.0592)|Esophageal squamous(101;0.162)					CACAACATATCTTCTGTCTAA	0.353													17	29					0	0	0	0
ABCD2	225	broad.mit.edu	37	12	39947723	39947723	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:39947723C>G	uc001rmb.2	-	10	2640	c.2214G>C	c.(2212-2214)GAG>GAC	p.E738D		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	738					fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						ATTAAGATGTCTCATCTTCAT	0.323													4	7					0	0	0	0
RACGAP1P	83956	broad.mit.edu	37	12	45459000	45459000	+	RNA	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:45459000C>T	uc001rol.2	-	1		c.195G>A				NR_026583				Homo sapiens FKSG42 (FKSG42) mRNA, complete cds.												0						AGTCAGTCCTCTCCCACTTTT	0.448													10	17					0	0	0	0
PPFIA2	8499	broad.mit.edu	37	12	81738464	81738464	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:81738464A>T	uc001szo.1	-	19	2402	c.2241T>A	c.(2239-2241)GAT>GAA	p.D747E	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	673										ovary(3)|lung(2)|pancreas(1)	6						GTTTCCTCAGATCACTTGGCT	0.279													3	0					0	0	0	0
DUSP6	1848	broad.mit.edu	37	12	89745444	89745444	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:89745444C>T	uc001tay.2	-	1	853	c.373G>A	c.(373-375)GAG>AAG	p.E125K	DUSP6_uc001taz.2_Missense_Mutation_p.E125K	NM_001946	NP_001937	Q16828	DUS6_HUMAN	dual specificity phosphatase 6 isoform a	125	Rhodanese.				dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						CGGCAGCCCTCGTCCTTGAGC	0.687													6	2					0	0	0	0
LUM	4060	broad.mit.edu	37	12	91502199	91502199	+	Silent	SNP	G	C	C	rs144214151		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:91502199G>C	uc001tbm.2	-	2	947	c.558C>G	c.(556-558)CTC>CTG	p.L186L	LUM_uc001tbn.2_Intron	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	186	LRR 6.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						CAAGGTATTCGAGTGATTTAA	0.433													40	12					0	0	0	0
C12orf51	283450	broad.mit.edu	37	12	112622228	112622228	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:112622228G>A	uc009zwc.2	-	54	9294	c.9276C>T	c.(9274-9276)GCC>GCT	p.A3092A		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GCTCGAGGCCGGCAGGCAGCG	0.627													11	1					0	0	0	0
TBX3	6926	broad.mit.edu	37	12	115109999	115109999	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:115109999G>A	uc001tvt.1	-	8	2843	c.1879C>T	c.(1879-1881)CCC>TCC	p.P627S	TBX3_uc001tvu.1_Missense_Mutation_p.P607S	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	627	Transcription repression.			SAAASSSVHRHPF -> LRQPQLRCTAPL (in Ref. 1).	anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		TTGAGGAAGGGGTGGCGGTGC	0.682													3	2					0	0	0	0
HNF1A	6927	broad.mit.edu	37	12	121438953	121438953	+	Silent	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:121438953C>A	uc001tzg.2	+	10	1877	c.1854C>A	c.(1852-1854)ATC>ATA	p.I618I	HNF1A_uc010szn.1_Silent_p.I625I	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	618			I -> M (in MODY3).		glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ACAGCGTCATCGAGACCTTCA	0.617									Hepatic_Adenoma_Familial_Clustering_of				10	5					1.58986e-06	1.99997e-06	1	0
CDK8	1024	broad.mit.edu	37	13	26911771	26911771	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:26911771G>C	uc001uqr.1	+	2	222	c.196G>C	c.(196-198)GAA>CAA	p.E66Q	CDK8_uc001uqs.1_Missense_Mutation_p.E66Q|CDK8_uc001uqt.1_5'UTR	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	66	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		GGCATGTAGAGAAATAGCAGT	0.289													30	51					0	0	0	0
ALG5	29880	broad.mit.edu	37	13	37524134	37524134	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:37524134C>T	uc001uvy.2	-	10	987	c.920G>A	c.(919-921)CGA>CAA	p.R307Q	ALG5_uc010teq.1_Missense_Mutation_p.R277Q|ALG5_uc010ter.1_RNA	NM_013338	NP_037470	Q9Y673	ALG5_HUMAN	dolichyl-phosphate beta-glucosyltransferase	307	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate beta-glucosyltransferase activity|oligosaccharyl transferase activity				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;5.79e-07)|Epithelial(112;1.81e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00785)|BRCA - Breast invasive adenocarcinoma(63;0.0127)|GBM - Glioblastoma multiforme(144;0.0472)		ATATCGAAGTCGTATAAAAAG	0.353													16	33					0	0	0	0
FREM2	341640	broad.mit.edu	37	13	39446956	39446956	+	Silent	SNP	G	T	T	rs147947821		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:39446956G>T	uc001uwv.2	+	17	8370	c.8061G>T	c.(8059-8061)GGG>GGT	p.G2687G		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2687	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCCCCGTGGGGGTAGGAGGCT	0.488													40	64					9.8876e-21	1.51724e-20	1	0
HTR2A	3356	broad.mit.edu	37	13	47409480	47409480	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:47409480G>A	uc001vbq.2	-	3	1042	c.908C>T	c.(907-909)CCA>CTA	p.P303L	HTR2A_uc001vbr.2_Missense_Mutation_p.P203L|HTR2A_uc010acr.2_Missense_Mutation_p.P303L	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	303	Cytoplasmic (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GTAGGACCCTGGCTCCCTATG	0.517													21	29					0	0	0	0
SLC15A1	6564	broad.mit.edu	37	13	99364806	99364806	+	Silent	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:99364806A>G	uc001vno.2	-	10	833	c.756T>C	c.(754-756)AGT>AGC	p.S252S		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	252	Cytoplasmic (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	GAAATGCCTTACTCCGATGCC	0.433													37	92					0	0	0	0
DOCK9	23348	broad.mit.edu	37	13	99452600	99452600	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:99452600G>A	uc001vnt.2	-	52	5958	c.5903C>T	c.(5902-5904)TCG>TTG	p.S1968L	DOCK9_uc001vnw.2_Missense_Mutation_p.S1967L|DOCK9_uc001vnq.2_Missense_Mutation_p.S515L|DOCK9_uc001vnr.2_Missense_Mutation_p.S597L|DOCK9_uc010tin.1_Missense_Mutation_p.S586L|DOCK9_uc001vns.2_Missense_Mutation_p.S503L|DOCK9_uc010tio.1_Missense_Mutation_p.S623L|DOCK9_uc010tip.1_Missense_Mutation_p.S664L	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1968	Potential.|DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CACCTCGGCCGAGGAGCACAG	0.612													11	21					0	0	0	0
COL4A1	1282	broad.mit.edu	37	13	110814632	110814632	+	Silent	SNP	G	A	A	rs149068853		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:110814632G>A	uc001vqw.3	-	48	4529	c.4407C>T	c.(4405-4407)CAC>CAT	p.H1469H	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1469	Collagen IV NC1.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AAGAGTACCCGTGGTAAAGAA	0.512													7	373					0	0	0	0
COL4A1	1282	broad.mit.edu	37	13	110828798	110828798	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr13:110828798C>T	uc001vqw.3	-	36	3153	c.3031G>A	c.(3031-3033)GGA>AGA	p.G1011R	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1011	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCAACAGATCCTTTTGGTCCC	0.483													23	44					0	0	0	0
Unknown	0	broad.mit.edu	37	14	19856854	19856854	+	RNA	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr14:19856854C>G	uc001vvq.1	-	5		c.676G>C								Homo sapiens cDNA FLJ12852 fis, clone NT2RP2003445.																		CTCATGTCATCTACAGCACTC	0.343													7	40					0	0	0	0
OR4Q3	441669	broad.mit.edu	37	14	20216179	20216179	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr14:20216179T>A	uc010tkt.1	+	1	593	c.593T>A	c.(592-594)GTG>GAG	p.V198E		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTGGTAGAGGTGCTGGTGATA	0.493													25	36					0	0	0	0
METTL3	56339	broad.mit.edu	37	14	21969087	21969087	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr14:21969087C>T	uc001wbc.2	-	5	1176	c.1084G>A	c.(1084-1086)GAT>AAT	p.D362N	METTL3_uc001wbb.2_Missense_Mutation_p.D207N|METTL3_uc010tlw.1_RNA	NM_019852	NP_062826	Q86U44	MTA70_HUMAN	methyltransferase like 3	362					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			pancreas(1)|skin(1)	2	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		GCACTGGAATCACCTCCGACA	0.507													12	8					0	0	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65194605	65194605	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr14:65194605C>T	uc001xho.1	+	2	525	c.256C>T	c.(256-258)CCT>TCT	p.P86S	PLEKHG3_uc001xhn.1_Missense_Mutation_p.P86S|PLEKHG3_uc001xhp.2_Missense_Mutation_p.P86S|PLEKHG3_uc010aqh.1_5'Flank	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	86					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		AGCGGCAGGGCCTGCACACCA	0.637													8	4					0	0	0	0
Unknown	0	broad.mit.edu	37	15	22473030	22473030	+	RNA	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:22473030G>T	uc001yuj.1	-	2		c.241C>A								Homo sapiens IGH mRNA for immunoglobulin heavy chain VHDJ region, partial cds, clone:H6.																		TTGAGGGACGGGTTGTAGTTG	0.567													65	159					6.20203e-27	9.813e-27	1	0
CYFIP1	23191	broad.mit.edu	37	15	22956494	22956494	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:22956494G>C	uc001yus.2	+	16	1835	c.1731G>C	c.(1729-1731)AAG>AAC	p.K577N	CYFIP1_uc001yut.2_Missense_Mutation_p.K577N|CYFIP1_uc010aya.1_Missense_Mutation_p.K605N|CYFIP1_uc001yuu.2_Missense_Mutation_p.K146N	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	577					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GTGGTTCCAAGAAAACCTTGA	0.408													32	15					0	0	0	0
C15orf2	23742	broad.mit.edu	37	15	24923926	24923926	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:24923926C>G	uc001ywo.2	+	1	3386	c.2912C>G	c.(2911-2913)GCT>GGT	p.A971G		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	971					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AATGCAAGTGCTTTCCCCAAT	0.483													28	16					0	0	0	0
SNORD115-13	100033450	broad.mit.edu	37	15	25438354	25438354	+	RNA	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:25438354C>G	uc001yzf.1	+	3		c.232C>G			SNORD115-13_uc001yzh.2_5'Flank|SNORD115-14_uc001yzj.1_5'Flank					Homo sapiens clone Rt-11 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0						GTGCTGAGCCCCTGGTGCACT	0.597													46	16					0	0	0	0
RYR3	6263	broad.mit.edu	37	15	33954863	33954863	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:33954863G>C	uc001zhi.2	+	35	5202	c.5132G>C	c.(5131-5133)CGA>CCA	p.R1711P	RYR3_uc010bar.2_Missense_Mutation_p.R1711P	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1711	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCCCACATCCGAGACCCTGTA	0.562													23	18					0	0	0	0
SLC24A5	283652	broad.mit.edu	37	15	48434437	48434437	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:48434437C>T	uc001zwe.2	+	9	1465	c.1392C>T	c.(1390-1392)GAC>GAT	p.D464D	SLC24A5_uc010bel.2_Silent_p.D404D|MYEF2_uc001zwg.3_3'UTR|MYEF2_uc001zwh.3_3'UTR|MYEF2_uc001zwi.3_3'UTR|MYEF2_uc001zwj.3_3'UTR|SLC24A5_uc001zwk.2_Silent_p.D95D	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	464	Extracellular (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		GGAAACTAGACAGAAAGTTGG	0.343													40	20					0	0	0	0
FBN1	2200	broad.mit.edu	37	15	48818391	48818391	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:48818391G>A	uc001zwx.1	-	9	1252	c.924C>T	c.(922-924)GTC>GTT	p.V308V		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	308	EGF-like 5; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AGTAACTGCTGACTGTGTTTG	0.403													50	11					0	0	0	0
SGK269	79834	broad.mit.edu	37	15	77474169	77474169	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:77474169C>T	uc002bcm.2	-	3	408	c.100G>A	c.(100-102)GAG>AAG	p.E34K	SGK269_uc002bcn.2_Missense_Mutation_p.E34K	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	34					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		GGTGCCTTCTCAGGGTCTGGG	0.468													8	182					0	0	0	0
BNC1	646	broad.mit.edu	37	15	83926817	83926817	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:83926817C>T	uc002bjt.1	-	5	2450	c.2362G>A	c.(2362-2364)GAA>AAA	p.E788K	BNC1_uc010uos.1_Missense_Mutation_p.E776K	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	788					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AAATGATCTTCACTACTCTCC	0.458													36	63					0	0	0	0
AKAP13	11214	broad.mit.edu	37	15	86124699	86124699	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:86124699G>A	uc002blv.1	+	7	3570	c.3400G>A	c.(3400-3402)GTG>ATG	p.V1134M	AKAP13_uc002blt.1_Missense_Mutation_p.V1134M|AKAP13_uc002blu.1_Missense_Mutation_p.V1134M|AKAP13_uc010bne.1_5'Flank	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	1134					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						AGGTTTGCCAGTGGCTCTACA	0.507													64	19					0	0	0	0
LRRK1	79705	broad.mit.edu	37	15	101567909	101567909	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr15:101567909G>T	uc002bwr.2	+	19	2912	c.2593G>T	c.(2593-2595)GAC>TAC	p.D865Y	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	865					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CAGCCGGGACGACGACGTGCA	0.662													12	7					7.93312e-07	1.00149e-06	1	0
GRIN2A	2903	broad.mit.edu	37	16	10274094	10274094	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:10274094G>T	uc002czo.3	-	2	723	c.175C>A	c.(175-177)CAG>AAG	p.Q59K	GRIN2A_uc010uym.1_Missense_Mutation_p.Q59K|GRIN2A_uc002czr.3_Missense_Mutation_p.Q59K|GRIN2A_uc010buk.2_Missense_Mutation_p.Q59K	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	59	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCCGCCGCCTGCTCGGGGCCC	0.657													44	77					1.8453e-21	2.86867e-21	1	0
ARHGAP17	55114	broad.mit.edu	37	16	24980081	24980081	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:24980081C>A	uc002dnb.2	-	5	378	c.285G>T	c.(283-285)GAG>GAT	p.E95D	ARHGAP17_uc002dnc.2_Missense_Mutation_p.E95D|ARHGAP17_uc010vcf.1_Intron|ARHGAP17_uc002dnf.2_Missense_Mutation_p.E3D|ARHGAP17_uc002dng.1_Missense_Mutation_p.E95D	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	95	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		CTCCACACGTCTCCAGCATCT	0.507													27	38					2.41591e-17	3.55398e-17	1	0
RABEP2	79874	broad.mit.edu	37	16	28917494	28917494	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:28917494G>A	uc002drq.2	-	9	1317	c.1269C>T	c.(1267-1269)TGC>TGT	p.C423C	uc010vct.1_Intron|RABEP2_uc010vdf.1_Silent_p.C352C|RABEP2_uc010byn.2_Silent_p.C391C	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	423	Potential.				endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						CTTGCCGCGTGCAGCACAGCA	0.716													7	10					0	0	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29888756	29888756	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:29888756A>T	uc002duq.3	-	11	1985	c.1745T>A	c.(1744-1746)CTG>CAG	p.L582Q	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.L512Q|SEZ6L2_uc002dur.3_Missense_Mutation_p.L512Q|SEZ6L2_uc002dus.3_Missense_Mutation_p.L468Q|SEZ6L2_uc010vec.1_Missense_Mutation_p.L582Q|SEZ6L2_uc010ved.1_Missense_Mutation_p.L538Q	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	582	CUB 3.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CCCGTCGAACAGCGTCAGCAT	0.692													10	26					0	0	0	0
VKORC1	79001	broad.mit.edu	37	16	31105904	31105904	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:31105904G>A	uc002eas.2	-	1	373	c.147C>T	c.(145-147)ATC>ATT	p.I49I	PRSS53_uc002ear.2_5'UTR|VKORC1_uc002eat.2_Silent_p.I49I|VKORC1_uc002eau.2_Silent_p.I49I	NM_024006	NP_076869	Q9BQB6	VKOR1_HUMAN	vitamin K epoxide reductase complex, subunit 1	49	Cytoplasmic (Potential).				peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane	vitamin-K-epoxide reductase (warfarin-sensitive) activity				0					Acenocoumarol(DB01418)|Dicumarol(DB00266)|Menadione(DB00170)|Phenindione(DB00498)|Phenprocoumon(DB00946)|Warfarin(DB00682)	GCGAACAGCTGATGGCGGTGC	0.682													12	11					0	0	0	0
Unknown	0	broad.mit.edu	37	16	32190817	32190817	+	RNA	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:32190817G>T	uc010vfv.1	-	7		c.1007C>A								Homo sapiens cDNA FLJ60890 complete cds, moderately similar to HECT domain and RCC1-like domain-containing protein 2.																		TGGCAAGCTCGTTGTCTTGTG	0.498													7	31					3.09899e-07	3.96848e-07	1	0
CMTM1	113540	broad.mit.edu	37	16	66603837	66603837	+	Splice_Site	SNP	A	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:66603837A>T	uc002epi.3	+	2	205	c.82_splice	c.e2-2	p.S28_splice	CMTM1_uc002epb.3_Splice_Site|CMTM1_uc002epc.3_Splice_Site|CMTM1_uc002epd.3_Intron|CMTM1_uc002epe.3_Intron|CMTM1_uc002epf.3_Intron|CMTM1_uc002epg.3_Intron|CMTM1_uc002eph.3_Splice_Site_p.S28_splice|CMTM1_uc002epl.3_Intron|CMTM1_uc002epj.3_Intron|CMTM1_uc002epk.3_Intron|CMTM1_uc002epa.3_Intron|CMTM1_uc002epn.3_Splice_Site_p.S145_splice|CMTM1_uc002epo.3_Splice_Site|CMTM1_uc002epp.3_Splice_Site|CMTM1_uc002epq.3_Splice_Site|CMTM1_uc010cds.2_Splice_Site|CMTM1_uc002epr.3_Splice_Site_p.S145_splice|CMTM1_uc002epm.3_Splice_Site|CMTM1_uc002eps.2_5'Flank	NM_181269	NP_851786	Q8IZ96	CKLF1_HUMAN	chemokine-like factor superfamily 1 isoform 1						chemotaxis	extracellular space|integral to membrane	cytokine activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)		CTTTTATTGCAGAGTCTTATC	0.323													31	57					0	0	0	0
FUK	197258	broad.mit.edu	37	16	70499039	70499039	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:70499039C>T	uc002eyy.2	+	4	303	c.245C>T	c.(244-246)TCC>TTC	p.S82F	FUK_uc010vmb.1_Intron|FUK_uc010cft.2_Missense_Mutation_p.S114F|FUK_uc002eyz.2_Intron	NM_145059	NP_659496	Q8N0W3	FUK_HUMAN	fucokinase	82						cytoplasm	ATP binding|fucokinase activity			ovary(1)	1		Ovarian(137;0.0694)				GTGGTCACATCCGATGTCCTG	0.572													11	14					0	0	0	0
PMFBP1	83449	broad.mit.edu	37	16	72188112	72188112	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:72188112C>T	uc002fcc.3	-	4	584	c.412G>A	c.(412-414)GAG>AAG	p.E138K	PMFBP1_uc002fcd.2_Missense_Mutation_p.E138K|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_5'UTR	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	138										ovary(2)	2		Ovarian(137;0.179)				GTCTATACCTCATCTTCTTTC	0.463													42	68					0	0	0	0
IRF8	3394	broad.mit.edu	37	16	85946795	85946795	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:85946795G>T	uc002fjh.2	+	5	563	c.506G>T	c.(505-507)TGT>TTT	p.C169F	IRF8_uc010chp.2_Intron	NM_002163	NP_002154	Q02556	IRF8_HUMAN	interferon regulatory factor 8	169					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|ovary(1)	3		Prostate(104;0.0771)				CCGGAGGCCTGTCGGAGTCAG	0.617													48	88					6.17242e-35	1.01731e-34	1	0
TP53	7157	broad.mit.edu	37	17	7577557	7577557	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:7577557A>T	uc002gim.2	-	7	918	c.724T>A	c.(724-726)TGC>AGC	p.C242S	TP53_uc002gig.1_Missense_Mutation_p.C242S|TP53_uc002gih.2_Missense_Mutation_p.C242S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C110S|TP53_uc010cng.1_Missense_Mutation_p.C110S|TP53_uc002gii.1_Missense_Mutation_p.C110S|TP53_uc010cnh.1_Missense_Mutation_p.C242S|TP53_uc010cni.1_Missense_Mutation_p.C242S|TP53_uc002gij.2_Missense_Mutation_p.C242S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C149S|TP53_uc002gio.2_Missense_Mutation_p.C110S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	242	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).	Zinc.	C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C242F(63)|p.C242Y(37)|p.C242S(25)|p.C242fs*5(16)|p.C242R(11)|p.C242W(7)|p.0?(7)|p.N239_C242delNSSC(3)|p.C242*(3)|p.S241del(2)|p.C242C(2)|p.C242G(2)|p.C242fs*20(1)|p.C242fs*23(1)|p.Y236_M243delYMCNSSCM(1)|p.C242_M246>L(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_C242insX(1)|p.C238fs*21(1)|p.C242fs*98(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241_G245delSCMGG(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGCCCATGCAGGAACTGTTA	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			67	22					0	0	0	0
MYH4	4622	broad.mit.edu	37	17	10351339	10351339	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:10351339G>A	uc002gmn.2	-	34	4872	c.4761C>T	c.(4759-4761)CTC>CTT	p.L1587L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1587	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TTAGCTGATCGAGTTCTTCAT	0.418													6	155					0	0	0	0
COX10	1352	broad.mit.edu	37	17	13977709	13977709	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:13977709A>G	uc002gof.3	+	2	317	c.113A>G	c.(112-114)CAT>CGT	p.H38R	COX10_uc010vvs.1_5'UTR|COX10_uc010vvt.1_5'UTR	NM_001303	NP_001294	Q12887	COX10_HUMAN	heme A:farnesyltransferase precursor	38					heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity				0		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		AAGTTCTTACATCTTCTCAGG	0.403													63	95					0	0	0	0
LYZL6	57151	broad.mit.edu	37	17	34266465	34266465	+	Translation_Start_Site	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:34266465G>T	uc002hkj.1	-	1	46	c.-104C>A	c.(-106--102)ACCTG>ACATG		LYZL6_uc002hkk.1_Intron	NM_020426	NP_065159	O75951	LYZL6_HUMAN	lysozyme-like 6 precursor						cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGGGCAGCCAGGTTTCCTTAC	0.418													8	23					0.00307968	0.00367908	1	0
THRA	7067	broad.mit.edu	37	17	38249328	38249328	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:38249328C>A	uc002htw.2	+	10	1649	c.1166C>A	c.(1165-1167)CCG>CAG	p.P389Q	THRA_uc002htx.2_Intron|NR1D1_uc002htz.1_3'UTR|NR1D1_uc010cwq.1_RNA	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	389					negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	GAAGGCCGGCCGGGCGGGTCA	0.552													31	57					4.4194e-11	5.9595e-11	1	0
RPS6KB1	6198	broad.mit.edu	37	17	58024140	58024140	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:58024140G>C	uc002ixy.2	+	15	1672	c.1569G>C	c.(1567-1569)ATG>ATC	p.M523I	RPS6KB1_uc010ddj.1_Intron|RPS6KB1_uc010wom.1_Missense_Mutation_p.M470I|RPS6KB1_uc010won.1_Missense_Mutation_p.M500I|RPS6KB1_uc010woo.1_Missense_Mutation_p.M458I|RPS6KB1_uc002ixz.2_RNA	NM_003161	NP_003152	P23443	KS6B1_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide	523	Autoinhibitory domain.				apoptosis|G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|negative regulation of apoptosis|phosphatidylinositol-mediated signaling|positive regulation of mitotic cell cycle|positive regulation of translational initiation|TOR signaling cascade	cell junction|cytoplasm|cytosol|mitochondrial outer membrane|nucleus|nucleus|synapse|synaptosome	ATP binding|protein binding|protein kinase activity			large_intestine(1)	1	all_cancers(5;1.63e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.57e-12)|all cancers(12;6.41e-11)			ACCTGCGTATGAATCTATGAC	0.463													31	45					0	0	0	0
RECQL5	9400	broad.mit.edu	37	17	73657115	73657115	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:73657115C>G	uc010dgl.2	-	6	1062	c.906G>C	c.(904-906)CAG>CAC	p.Q302H	RECQL5_uc010dgk.2_Missense_Mutation_p.Q275H|RECQL5_uc002jpb.1_Missense_Mutation_p.Q302H|RECQL5_uc002joz.3_Missense_Mutation_p.Q302H|RECQL5_uc002jpa.3_Missense_Mutation_p.Q302H	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	302	Helicase C-terminal.				DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			TCCAGTCGTTCTGCACCAGCG	0.453								Other_identified_genes_with_known_or_suspected_DNA_repair_function					14	110					0	0	0	0
GAA	2548	broad.mit.edu	37	17	78081647	78081647	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr17:78081647G>A	uc002jxo.2	+	6	1089	c.907G>A	c.(907-909)GAC>AAC	p.D303N	GAA_uc002jxp.2_Missense_Mutation_p.D303N|GAA_uc002jxq.2_Missense_Mutation_p.D303N	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	303					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GGCGCTGGAGGACGGCGGGTC	0.677													3	25					0	0	0	0
LAMA1	284217	broad.mit.edu	37	18	7079974	7079974	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr18:7079974C>G	uc002knm.2	-	3	439	c.345G>C	c.(343-345)CAG>CAC	p.Q115H	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	115	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTCACCTACCTGTCTTAAGT	0.468													9	59					0	0	0	0
C18orf1	753	broad.mit.edu	37	18	13621229	13621229	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr18:13621229C>T	uc002ksa.2	+	5	963	c.295C>T	c.(295-297)CGC>TGC	p.R99C	C18orf1_uc002ksb.2_Missense_Mutation_p.R99C|C18orf1_uc002kse.2_Missense_Mutation_p.R62C|C18orf1_uc002ksf.2_Missense_Mutation_p.R62C|C18orf1_uc002ksg.1_Missense_Mutation_p.R22C|C18orf1_uc002ksh.1_Missense_Mutation_p.R41C|C18orf1_uc002ksi.1_Missense_Mutation_p.R41C	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	99	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		CTTCATCAACCGCCCGAACCA	0.637													102	29					0	0	0	0
HRH4	59340	broad.mit.edu	37	18	22056718	22056718	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr18:22056718A>T	uc002kvi.2	+	3	465	c.365A>T	c.(364-366)TAT>TTT	p.Y122F	HRH4_uc010xbd.1_Missense_Mutation_p.L67F|HRH4_uc010dlx.2_Intron	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	122	Cytoplasmic (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	TAGGTGTCTTATAGAACTCAA	0.378													7	42					0	0	0	0
ZNF521	25925	broad.mit.edu	37	18	22804737	22804737	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr18:22804737C>A	uc002kvk.2	-	4	3392	c.3145G>T	c.(3145-3147)GGG>TGG	p.G1049W	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.G1049W|ZNF521_uc002kvl.2_Missense_Mutation_p.G829W	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1049					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					ACTGCAGACCCATTCCCTGTC	0.522			T	PAX5	ALL								19	20					8.00594e-06	9.93071e-06	1	0
CD226	10666	broad.mit.edu	37	18	67614187	67614187	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr18:67614187G>A	uc010dqo.2	-	2	612	c.165C>T	c.(163-165)ACC>ACT	p.T55T	CD226_uc002lkm.3_Silent_p.T55T	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	55	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				AATCCTGCTGGGTCCCGATCT	0.463													21	15					0	0	0	0
SAFB2	9667	broad.mit.edu	37	19	5598876	5598876	+	Silent	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:5598876C>G	uc002mcd.2	-	13	1922	c.1710G>C	c.(1708-1710)CGG>CGC	p.R570R		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		TCACGACCGTCCGCTCCATTC	0.507													26	48					0	0	0	0
DUS3L	56931	broad.mit.edu	37	19	5786796	5786796	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:5786796C>T	uc002mdc.2	-	9	1547	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	PRR22_uc002mdb.1_5'Flank|PRR22_uc010xiv.1_5'Flank|DUS3L_uc002mdd.2_Missense_Mutation_p.E242K|DUS3L_uc010duk.2_Missense_Mutation_p.E149K	NM_020175	NP_064560	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like isoform 1	484					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding				0						TGCACGCACTCCTCGATGTAC	0.612													19	33					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9000496	9000496	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:9000496C>A	uc002mkp.2	-	54	40692	c.40488G>T	c.(40486-40488)ATG>ATT	p.M13496I	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.M313I|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13498	SEA 10.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGGGTGATGCATGTTCTCCT	0.478													33	66					9.65021e-13	1.33676e-12	1	0
ZNF560	147741	broad.mit.edu	37	19	9577562	9577562	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:9577562G>A	uc002mlp.1	-	10	2271	c.2061C>T	c.(2059-2061)AAC>AAT	p.N687N	ZNF560_uc010dwr.1_Silent_p.N581N	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	687					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						TTCCACATGCGTTACATTCAG	0.373													69	111					0	0	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10221511	10221511	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:10221511C>T	uc002mna.2	+	11	1170	c.1170C>T	c.(1168-1170)TTC>TTT	p.F390F	PPAN-P2RY11_uc010xla.1_Silent_p.F390F|P2RY11_uc002mnc.2_5'Flank|PPAN_uc002mmz.1_Silent_p.F390F|PPAN_uc002mnb.1_Silent_p.F337F	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	390					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			TCGAGTATTTCTGCCAGGCGG	0.607													67	140					0	0	0	0
KRI1	65095	broad.mit.edu	37	19	10665770	10665770	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:10665770G>C	uc002moy.1	-	18	1801	c.1792C>G	c.(1792-1794)CGA>GGA	p.R598G	KRI1_uc002mow.1_Missense_Mutation_p.R217G|KRI1_uc002mox.1_Missense_Mutation_p.R594G	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	598										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			tactcttctCGGCAGAGTGAC	0.303													25	39					0	0	0	0
ZNF878	729747	broad.mit.edu	37	19	12155285	12155285	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:12155285A>G	uc002mta.1	-	5	1072	c.1072T>C	c.(1072-1074)TAT>CAT	p.Y358H		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	311	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TTACACTCATAGGGTTTCTCT	0.403													33	74					0	0	0	0
CYP4F22	126410	broad.mit.edu	37	19	15651373	15651373	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:15651373C>T	uc002nbh.3	+	8	951	c.784C>T	c.(784-786)CGG>TGG	p.R262W		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	262						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						GGCGGATGGGCGGAGGTTCCG	0.607													29	90					0	0	0	0
UNC13A	23025	broad.mit.edu	37	19	17728564	17728564	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:17728564G>A	uc002nhd.2	-	40	4769	c.4769C>T	c.(4768-4770)ACG>ATG	p.T1590M		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1502	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						GGTGGCCTGCGTGTAGAGCGA	0.607													50	72					0	0	0	0
DYRK1B	9149	broad.mit.edu	37	19	40321360	40321360	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:40321360C>T	uc002omj.2	-	3	407	c.127G>A	c.(127-129)GCC>ACC	p.A43T	DYRK1B_uc002omi.2_Missense_Mutation_p.A43T|DYRK1B_uc002omk.2_Missense_Mutation_p.A43T|DYRK1B_uc002oml.2_Missense_Mutation_p.A43T	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	43					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			CGCAGCGGGGCTGAGGTTGCA	0.642													30	42					0	0	0	0
ZNF226	7769	broad.mit.edu	37	19	44680226	44680226	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:44680226C>T	uc002oyp.2	+	6	955	c.811C>T	c.(811-813)CAG>TAG	p.Q271*	ZNF226_uc002oyq.2_Nonsense_Mutation_p.Q154*|ZNF226_uc002oyr.2_Nonsense_Mutation_p.Q154*|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Nonsense_Mutation_p.Q271*|ZNF226_uc002oyt.2_Nonsense_Mutation_p.Q271*	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	271	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				TGATCTTCATCAGCAGTTACA	0.423													23	42					0	0	0	0
ZNF233	353355	broad.mit.edu	37	19	44778658	44778658	+	Silent	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:44778658G>T	uc002oyz.1	+	5	1972	c.1845G>T	c.(1843-1845)ACG>ACT	p.T615T	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Silent_p.T430T	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	615					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				GGATCCACACGGGAGAGAAAC	0.438													38	56					1.06647e-15	1.54335e-15	1	0
ZFP112	7771	broad.mit.edu	37	19	44832694	44832694	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:44832694C>G	uc010ejj.2	-	5	1747	c.1634G>C	c.(1633-1635)AGA>ACA	p.R545T	ZFP112_uc002ozc.3_Missense_Mutation_p.R539T|ZFP112_uc010xwy.1_Missense_Mutation_p.R562T|ZFP112_uc010xwz.1_Missense_Mutation_p.R544T	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	545	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TGTGTGGACTCTCTGATGAAC	0.423													61	101					0	0	0	0
FCAR	2204	broad.mit.edu	37	19	55396680	55396680	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:55396680C>A	uc002qhr.1	+	3	301	c.104C>A	c.(103-105)TCG>TAG	p.S35*	FCAR_uc002qhq.2_Nonsense_Mutation_p.S35*|FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Nonsense_Mutation_p.S8*|FCAR_uc010esi.1_Nonsense_Mutation_p.S8*|FCAR_uc002qhu.1_Nonsense_Mutation_p.S35*|FCAR_uc002qhv.1_Nonsense_Mutation_p.S35*|FCAR_uc002qhw.1_Nonsense_Mutation_p.S23*|FCAR_uc002qhx.1_Nonsense_Mutation_p.S23*|FCAR_uc002qhy.1_Nonsense_Mutation_p.S23*|FCAR_uc002qhz.1_Nonsense_Mutation_p.S23*|FCAR_uc002qia.1_Intron	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	35	Extracellular (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		TCTGCCAAATCGAGTCCTGTG	0.498													22	34					3.62473e-10	4.81494e-10	1	0
ZIM3	114026	broad.mit.edu	37	19	57646307	57646307	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:57646307C>T	uc002qnz.1	-	5	1784	c.1398G>A	c.(1396-1398)CAG>CAA	p.Q466Q		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	466	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAATTCTTTTCTGGTGCCTAA	0.428													49	70					0	0	0	0
ZNF776	284309	broad.mit.edu	37	19	58265188	58265188	+	Silent	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:58265188C>A	uc002qpx.2	+	3	913	c.690C>A	c.(688-690)CTC>CTA	p.L230L	ZNF587_uc002qqb.2_Intron|ZNF776_uc002qqa.2_Silent_p.L230L	NM_173632	NP_775903	Q68DI1	ZN776_HUMAN	zinc finger protein 776	230	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		AGAGACTTCTCCCTAGAGAAG	0.418													38	69					1.04594e-18	1.57112e-18	1	0
KIDINS220	57498	broad.mit.edu	37	2	8936972	8936972	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:8936972T>C	uc002qzc.2	-	11	1209	c.1027A>G	c.(1027-1029)ACC>GCC	p.T343A	KIDINS220_uc010yiv.1_Missense_Mutation_p.T109A|KIDINS220_uc002qzd.2_Missense_Mutation_p.T301A|KIDINS220_uc010yiw.1_Missense_Mutation_p.T344A	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	343	Cytoplasmic (Potential).|ANK 11.				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CTCATCTTGGTAGCCTTTATA	0.418													64	121					0	0	0	0
APOB	338	broad.mit.edu	37	2	21228818	21228818	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:21228818G>T	uc002red.2	-	26	11050	c.10922C>A	c.(10921-10923)TCT>TAT	p.S3641Y		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3641					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GAAAGACCCAGAATGAATCCG	0.463													14	26					1.5842e-08	2.05082e-08	1	0
BIRC6	57448	broad.mit.edu	37	2	32728276	32728276	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:32728276G>A	uc010ezu.2	+	49	9606	c.9472G>A	c.(9472-9474)GAA>AAA	p.E3158K		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3158					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TGACAATGCTGAAGGGATTCA	0.338													7	17					0	0	0	0
LRRTM1	347730	broad.mit.edu	37	2	80529897	80529897	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:80529897C>A	uc002sok.1	-	2	1318	c.1048G>T	c.(1048-1050)GGC>TGC	p.G350C	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	350	LRRCT.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						ACGTCCTCGCCCTGTGCGTAC	0.672										HNSCC(69;0.2)			14	20					1.5842e-08	2.05082e-08	1	0
Unknown	0	broad.mit.edu	37	2	90139424	90139424	+	RNA	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:90139424C>A	uc010fhm.2	+	18		c.2217C>A								Parts of antibodies, mostly variable regions.																		CAGAGAAAGCCCCTAAGTCCC	0.522													103	218					3.52173e-36	5.85857e-36	1	0
MITD1	129531	broad.mit.edu	37	2	99797327	99797327	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:99797327C>T	uc002szs.1	-	1	166	c.118G>A	c.(118-120)GAG>AAG	p.E40K	MRPL30_uc002szl.1_Intron|MRPL30_uc002szr.2_Intron|MRPL30_uc002szt.1_5'Flank|MRPL30_uc002szu.2_5'Flank|MRPL30_uc002szv.2_5'Flank	NM_138798	NP_620153	Q8WV92	MITD1_HUMAN	MIT, microtubule interacting and transport,	40	MIT.				protein transport	late endosome membrane				large_intestine(1)|ovary(1)	2						TCAATCCCCTCTTGGTAACAC	0.582													65	104					0	0	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143913079	143913079	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:143913079C>G	uc002tvm.3	+	2	171	c.20C>G	c.(19-21)TCT>TGT	p.S7C	ARHGAP15_uc010zbl.1_Missense_Mutation_p.S7C	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	7					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		TCTACAAATTCTGATACTTCC	0.373													11	18					0	0	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143913203	143913203	+	Silent	SNP	T	C	C	rs146989390	by1000genomes	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:143913203T>C	uc002tvm.3	+	2	295	c.144T>C	c.(142-144)GAT>GAC	p.D48D	ARHGAP15_uc010zbl.1_Silent_p.D48D	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	48					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		TCCTCACCGATGTCGGGAAGG	0.423													26	23					0	0	0	0
KCNJ3	3760	broad.mit.edu	37	2	155711512	155711512	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:155711512A>G	uc002tyv.1	+	3	1388	c.1193A>G	c.(1192-1194)AAA>AGA	p.K398R	KCNJ3_uc010zce.1_3'UTR	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	398	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	ATTACTACAAAACTACCATCT	0.388													64	98					0	0	0	0
SCN3A	6328	broad.mit.edu	37	2	165986510	165986510	+	Silent	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:165986510G>T	uc002ucx.2	-	17	3354	c.2862C>A	c.(2860-2862)GTC>GTA	p.V954V	SCN3A_uc002ucy.2_Silent_p.V905V|SCN3A_uc002ucz.2_Silent_p.V905V|SCN3A_uc002uda.1_Silent_p.V774V|SCN3A_uc002udb.1_Silent_p.V774V	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	954						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTTGGCCAGCGACCTCCATAC	0.468													188	143					3.0798e-103	5.24598e-103	1	0
NFE2L2	4780	broad.mit.edu	37	2	178098973	178098973	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:178098973C>G	uc002ulh.3	-	2	627	c.72G>C	c.(70-72)TGG>TGC	p.W24C	NFE2L2_uc002ulg.3_Missense_Mutation_p.W8C|NFE2L2_uc010zfa.1_Missense_Mutation_p.W8C|NFE2L2_uc002uli.3_Missense_Mutation_p.W8C|NFE2L2_uc010fra.2_Missense_Mutation_p.W8C|NFE2L2_uc010frb.2_Missense_Mutation_p.W8C	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	24					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TATCTTGCCTCCAAAGTATGT	0.348			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			19	20					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179465721	179465721	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:179465721C>A	uc010zfg.1	-	237	48430	c.48206G>T	c.(48205-48207)CGT>CTT	p.R16069L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R9764L|TTN_uc010zfi.1_Missense_Mutation_p.R9697L|TTN_uc010zfj.1_Missense_Mutation_p.R9572L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16996							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCACATCACGCTTATTGCA	0.488													138	102					2.82259e-58	4.73982e-58	1	0
TTN	7273	broad.mit.edu	37	2	179596593	179596593	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:179596593C>G	uc010zfg.1	-	55	13501	c.13277G>C	c.(13276-13278)TGG>TCG	p.W4426S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.W1087S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5353							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTTTGAACCAAGTGATCTC	0.428													37	139					0	0	0	0
Unknown	0	broad.mit.edu	37	2	190788606	190788606	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:190788606C>T	uc002uro.2	+	1	688	c.545C>T	c.(544-546)GCC>GTC	p.A182V						SubName: Full=cDNA FLJ54127, highly similar to Heterogeneous nuclear ribonucleoproteins C;																		GACCTTCAGGCCATTAAGAGG	0.433													7	324					0	0	0	0
CCDC150	284992	broad.mit.edu	37	2	197538986	197538986	+	Missense_Mutation	SNP	A	G	G	rs36060491		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:197538986A>G	uc002utp.1	+	10	1186	c.1051A>G	c.(1051-1053)AAA>GAA	p.K351E	CCDC150_uc010zgq.1_RNA|CCDC150_uc010zgr.1_RNA|CCDC150_uc010zgs.1_Missense_Mutation_p.K19E	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	351											0						CCAATTGACTAAAAAGTGTTC	0.338													7	9					0	0	0	0
AOX1	316	broad.mit.edu	37	2	201468754	201468754	+	Silent	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:201468754C>G	uc002uvx.2	+	8	704	c.603C>G	c.(601-603)CTC>CTG	p.L201L		NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	201					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GTCCAAAACTCTTCGCAGAAG	0.303													32	30					0	0	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170044	207170044	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:207170044G>C	uc002vbp.2	+	5	1042	c.792G>C	c.(790-792)ATG>ATC	p.M264I		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	264							nucleic acid binding|zinc ion binding			ovary(3)	3						CTTTACGCATGAATTCAGATA	0.388													30	25					0	0	0	0
C2orf67	151050	broad.mit.edu	37	2	210893657	210893657	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:210893657A>C	uc002vds.2	-	11	2516	c.2308T>G	c.(2308-2310)TAT>GAT	p.Y770D	C2orf67_uc002vdt.2_Missense_Mutation_p.Y728D	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	770										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		TCTATGTCATAAGAGCTCTCA	0.368													45	65					0	0	0	0
CPS1	1373	broad.mit.edu	37	2	211473158	211473158	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:211473158G>A	uc002vee.3	+	19	2398	c.2266G>A	c.(2266-2268)GGG>AGG	p.G756R	CPS1_uc010fur.2_Missense_Mutation_p.G762R|CPS1_uc010fus.2_Missense_Mutation_p.G305R	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	756					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CGTCGTATCCGGGAAGACATC	0.433													76	85					0	0	0	0
TNS1	7145	broad.mit.edu	37	2	218751275	218751275	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:218751275T>A	uc002vgt.2	-	11	984	c.586A>T	c.(586-588)AAC>TAC	p.N196Y	TNS1_uc002vgr.2_Missense_Mutation_p.N196Y|TNS1_uc002vgs.2_Missense_Mutation_p.N196Y|TNS1_uc010zjv.1_Missense_Mutation_p.N196Y|TNS1_uc010fvj.1_Missense_Mutation_p.N264Y|TNS1_uc010fvk.1_Missense_Mutation_p.N321Y|TNS1_uc002vgu.3_Missense_Mutation_p.N227Y|TNS1_uc010fvi.1_5'Flank	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	196	C2 tensin-type.					cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GACTCAAAGTTGGGGATGCCG	0.522											OREG0015188	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	5					0	0	0	0
HAO1	54363	broad.mit.edu	37	20	7895010	7895010	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr20:7895010C>T	uc002wmw.1	-	3	370	c.346G>A	c.(346-348)GAA>AAA	p.E116K	HAO1_uc010gbu.2_Missense_Mutation_p.E116K	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	116	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						GCCACTTCTTCAATTGAGGAG	0.532													14	36					0	0	0	0
BAGE2	85319	broad.mit.edu	37	21	11058168	11058168	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr21:11058168A>T	uc002yit.1	-	3	480	c.272T>A	c.(271-273)CTG>CAG	p.L91Q	BAGE_uc002yiw.1_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TACATCTTTCAGGAGCTTGGT	0.388													4	47					0	0	0	0
KRTAP27-1	643812	broad.mit.edu	37	21	31709388	31709388	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr21:31709388C>A	uc002ynx.1	-	1	625	c.599G>T	c.(598-600)GGT>GTT	p.G200V		NM_001077711	NP_001071179	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	200						intermediate filament				ovary(2)	2						TTGAGAACCACCAGTAACACA	0.408													14	29					0.000219431	0.000266613	1	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253706	32253706	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr21:32253706G>T	uc002yov.2	-	1	169	c.138C>A	c.(136-138)TTC>TTA	p.F46L		NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	46						keratin filament	structural molecule activity			pancreas(1)	1						AGCCAGTCTGGAAGGAACTGG	0.582													24	39					6.21321e-17	9.06518e-17	1	0
TIAM1	7074	broad.mit.edu	37	21	32554912	32554912	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr21:32554912C>T	uc002yow.1	-	16	3185	c.2713G>A	c.(2713-2715)GCC>ACC	p.A905T	TIAM1_uc011adk.1_Missense_Mutation_p.A905T|TIAM1_uc011adl.1_Missense_Mutation_p.A845T	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	905	PDZ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GAGTTCAGGGCGTCAGCAGCA	0.498													5	63					0	0	0	0
HSF2BP	11077	broad.mit.edu	37	21	45076541	45076541	+	Silent	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr21:45076541T>A	uc002zdi.2	-	3	446	c.114A>T	c.(112-114)ATA>ATT	p.I38I	RRP1B_uc002zdk.2_5'Flank|HSF2BP_uc011aey.1_Intron	NM_007031	NP_008962	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding	38					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.18)		AGAAGTCCCGTATTTGCATCA	0.393													39	51					0	0	0	0
COL6A2	1292	broad.mit.edu	37	21	47552400	47552400	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr21:47552400C>A	uc002zia.1	+	28	3076	c.2994C>A	c.(2992-2994)CAC>CAA	p.H998Q	COL6A2_uc002zib.1_Missense_Mutation_p.H404Q|COL6A2_uc002zic.1_Missense_Mutation_p.T73K|COL6A2_uc010gqe.1_RNA	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	998	Nonhelical region.|VWFA 3.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CCGTGTTCCACGAGAAGGACT	0.572													7	18					8.12818e-05	9.97805e-05	1	0
LOC96610	96610	broad.mit.edu	37	22	23241819	23241819	+	RNA	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr22:23241819C>A	uc011aim.1	+	366		c.15435C>A			uc002zws.2_Intron					Parts of antibodies, mostly variable regions.												0						GCGGAGGGACCAAGCTGACCG	0.542													39	45					6.1244e-12	8.32171e-12	1	0
MYO18B	84700	broad.mit.edu	37	22	26242186	26242187	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr22:26242186_26242187CC>AA	uc003abz.1	+	19	3738_3739	c.3488_3489CC>AA	c.(3487-3489)ACC>AAA	p.T1163K	MYO18B_uc003aca.1_Missense_Mutation_p.T1044K|MYO18B_uc010guy.1_Missense_Mutation_p.T1045K|MYO18B_uc010guz.1_Missense_Mutation_p.T1044K|MYO18B_uc011aka.1_Missense_Mutation_p.T317K|MYO18B_uc011akb.1_Missense_Mutation_p.T676K	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1163	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GTGAGGAGGACCTTTGCCAGCA	0.668													27	36					0	0	0	0
DOCK3	1795	broad.mit.edu	37	3	51400017	51400017	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:51400017G>A	uc011bds.1	+	49	5228	c.5205G>A	c.(5203-5205)TCG>TCA	p.S1735S		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1735	Ser-rich.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TTCTGTCCTCGTCCCAGGCAA	0.557													32	18					0	0	0	0
PDZRN3	23024	broad.mit.edu	37	3	73432909	73432909	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:73432909C>A	uc003dpl.1	-	10	2904	c.2808G>T	c.(2806-2808)AGG>AGT	p.R936S	PDZRN3_uc011bgh.1_Missense_Mutation_p.R593S|PDZRN3_uc010hoe.1_Missense_Mutation_p.R634S|PDZRN3_uc011bgf.1_Missense_Mutation_p.R653S|PDZRN3_uc011bgg.1_Missense_Mutation_p.R656S	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	936							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CCCGCACGGGCCTCTTGGTGA	0.667													19	13					3.99206e-14	5.59517e-14	1	0
OR5H1	26341	broad.mit.edu	37	3	97852283	97852283	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:97852283G>T	uc011bgt.1	+	1	742	c.742G>T	c.(742-744)GTC>TTC	p.V248F		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						TCTCTTCTCTGTCTCTTTATA	0.413													45	160					3.7052e-28	5.91503e-28	1	0
MORC1	27136	broad.mit.edu	37	3	108778707	108778707	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:108778707T>G	uc003dxl.2	-	12	1064	c.977A>C	c.(976-978)CAG>CCG	p.Q326P	MORC1_uc011bhn.1_Missense_Mutation_p.Q326P	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	326	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CAAAGCTCTCTGTAATACATC	0.358													7	51					0	0	0	0
PLXNA1	5361	broad.mit.edu	37	3	126736700	126736700	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:126736700G>A	uc003ejg.2	+	18	3560	c.3556G>A	c.(3556-3558)GAG>AAG	p.E1186K		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1209	Extracellular (Potential).|IPT/TIG 4.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		ACTGCTGTGCGAGGCGCCCAA	0.662													22	71					0	0	0	0
ATP2C1	27032	broad.mit.edu	37	3	130698095	130698095	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:130698095C>T	uc003enl.2	+	19	1795	c.1573C>T	c.(1573-1575)CTT>TTT	p.L525F	ATP2C1_uc011blg.1_Missense_Mutation_p.L559F|ATP2C1_uc011blh.1_Missense_Mutation_p.L520F|ATP2C1_uc011bli.1_Missense_Mutation_p.L559F|ATP2C1_uc003enk.2_Missense_Mutation_p.L509F|ATP2C1_uc003enm.2_Missense_Mutation_p.L525F|ATP2C1_uc003enn.2_Missense_Mutation_p.L509F|ATP2C1_uc003eno.2_Missense_Mutation_p.L525F|ATP2C1_uc003enp.2_Missense_Mutation_p.L525F|ATP2C1_uc003enq.2_Missense_Mutation_p.L525F|ATP2C1_uc003enr.2_Missense_Mutation_p.L525F|ATP2C1_uc003ens.2_Missense_Mutation_p.L525F|ATP2C1_uc003ent.2_Missense_Mutation_p.L525F|ATP2C1_uc003enu.2_Missense_Mutation_p.L203F	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	525	Cytoplasmic (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	TTCCTAAGTTCTTGCTTTGGC	0.373									Hailey-Hailey_disease				8	164					0	0	0	0
PLCH1	23007	broad.mit.edu	37	3	155203145	155203145	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:155203145C>T	uc011bok.1	-	22	3275	c.2998G>A	c.(2998-3000)GCA>ACA	p.A1000T	PLCH1_uc011boj.1_Missense_Mutation_p.V1000I|PLCH1_uc011bol.1_Missense_Mutation_p.A962T	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1000					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			AGCATCTTACCTAGAGAGTTT	0.423													13	50					0	0	0	0
RSRC1	51319	broad.mit.edu	37	3	157920993	157920993	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:157920993G>C	uc003fbt.2	+	4	564	c.453G>C	c.(451-453)AAG>AAC	p.K151N	RSRC1_uc011bou.1_Intron|RSRC1_uc003fbu.1_Missense_Mutation_p.K151N|RSRC1_uc003fbv.2_Intron	NM_016625	NP_057709	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	151				EK -> GE (in Ref. 3; AAF64267).	nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding				0			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			aaaaggagaaggataaaggga	0.368													9	25					0	0	0	0
SLC2A2	6514	broad.mit.edu	37	3	170716928	170716928	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:170716928G>T	uc003fhe.1	-	9	1405	c.1096C>A	c.(1096-1098)CGT>AGT	p.R366S	SLC2A2_uc003fhf.1_Missense_Mutation_p.R193S|SLC2A2_uc011bpu.1_Missense_Mutation_p.R239S	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	366	Cytoplasmic (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			AAGAGAGAACGTCGCCCTGCC	0.398													39	107					2.54651e-27	4.04713e-27	1	0
LOC220729	220729	broad.mit.edu	37	3	197348674	197348674	+	RNA	SNP	A	G	G	rs144273946	by1000genomes	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:197348674A>G	uc011bug.1	-	4		c.417T>C			LOC220729_uc003fxw.2_RNA|LOC220729_uc003fxy.2_RNA|LOC220729_uc010iao.1_Intron					Homo sapiens cDNA FLJ60865 complete cds, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1).												0						GGCTCTGTCCACCAAATGCAC	0.478													4	152					0	0	0	0
TECRL	253017	broad.mit.edu	37	4	65147243	65147243	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr4:65147243G>A	uc003hcv.2	-	10	976	c.867C>T	c.(865-867)AAC>AAT	p.N289N	TECRL_uc010ihi.2_RNA	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	289					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						ATGTGAAGGGGTTATAATTTG	0.328													19	7					0	0	0	0
NUDT9	53343	broad.mit.edu	37	4	88344060	88344060	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr4:88344060G>A	uc003hqq.2	+	1	326	c.3G>A	c.(1-3)ATG>ATA	p.M1I	NUDT9_uc003hqr.2_Intron|NUDT9_uc010ikl.2_Missense_Mutation_p.M1I	NM_024047	NP_076952	Q9BW91	NUDT9_HUMAN	nudix-type motif 9 isoform a	1						mitochondrion	ADP-ribose diphosphatase activity				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000937)		GGGCGCTCATGGCGGGACGCC	0.672													32	52					0	0	0	0
ANKRD50	57182	broad.mit.edu	37	4	125600031	125600031	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr4:125600031T>G	uc003ifg.3	-	2	808	c.542A>C	c.(541-543)AAG>ACG	p.K181T	ANKRD50_uc011cgo.1_Missense_Mutation_p.K2T|ANKRD50_uc010inw.2_Missense_Mutation_p.K181T	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	181										central_nervous_system(1)	1						CTGGGGAGGCTTCATTCCCAG	0.398													3	99					0	0	0	0
PCDH10	57575	broad.mit.edu	37	4	134072226	134072226	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr4:134072226G>C	uc003iha.2	+	1	1757	c.931G>C	c.(931-933)GAG>CAG	p.E311Q	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.E311Q	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	311	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TGGCAGACTGGAGGTAAGCGG	0.632													37	23					0	0	0	0
NPY5R	4889	broad.mit.edu	37	4	164272687	164272687	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr4:164272687A>G	uc003iqn.2	+	4	1444	c.1262A>G	c.(1261-1263)AAT>AGT	p.N421S		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	421	Helical; Name=7; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				TGTTGTCTTAATCCAATTCTA	0.328													45	20					0	0	0	0
CEP72	55722	broad.mit.edu	37	5	637653	637653	+	Missense_Mutation	SNP	C	T	T	rs143077618		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:637653C>T	uc003jbf.2	+	7	998	c.926C>T	c.(925-927)TCG>TTG	p.S309L	CEP72_uc011clz.1_RNA	NM_018140	NP_060610	Q9P209	CEP72_HUMAN	centrosomal protein 72 kDa	309					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			ACCGAGGACTCGGCCTCTTCT	0.527													28	50					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13719184	13719184	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:13719184G>T	uc003jfd.2	-	72	12348	c.12306C>A	c.(12304-12306)TGC>TGA	p.C4102*	DNAH5_uc003jfc.2_Nonsense_Mutation_p.C270*	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4102	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GTCCCAGATGGCAGTTCTGCA	0.418									Kartagener_syndrome				22	29					1.10513e-12	1.52491e-12	1	0
FBXL7	23194	broad.mit.edu	37	5	15616151	15616151	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:15616151A>G	uc003jfn.1	+	2	578	c.97A>G	c.(97-99)AAA>GAA	p.K33E		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	33					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CACGCCCACTAAAGCCCAGAA	0.453													10	25					0	0	0	0
CDH9	1007	broad.mit.edu	37	5	26885803	26885803	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:26885803G>T	uc003jgs.1	-	11	1971	c.1802C>A	c.(1801-1803)ACC>AAC	p.T601N	CDH9_uc011cnv.1_Missense_Mutation_p.T194N	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	601	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						GGCTTCTGCGGTGCAGGATTG	0.488													6	20					5.9392e-07	7.5244e-07	1	0
DAB2	1601	broad.mit.edu	37	5	39376143	39376143	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:39376143C>G	uc003jlx.2	-	13	2734	c.2203G>C	c.(2203-2205)GAG>CAG	p.E735Q	DAB2_uc003jlw.2_Missense_Mutation_p.E714Q	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	735	Required for interaction with MYO6 (By similarity).				cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			AAAGGGTTCTCAAATGCATTG	0.418													19	36					0	0	0	0
MAST4	375449	broad.mit.edu	37	5	66429471	66429471	+	Silent	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:66429471A>G	uc003jut.1	+	16	1724	c.1656A>G	c.(1654-1656)AAA>AAG	p.K552K	MAST4_uc003juu.1_Silent_p.K562K|MAST4_uc011cra.1_Silent_p.K535K|MAST4_uc003juv.2_Silent_p.K547K|MAST4_uc003juw.2_Silent_p.K547K	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	744	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		TCCTGGATAAACAGGTAAGCT	0.408													21	37					0	0	0	0
GIN1	54826	broad.mit.edu	37	5	102423676	102423676	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:102423676C>A	uc003koa.1	-	8	1577	c.1495G>T	c.(1495-1497)GAT>TAT	p.D499Y	GIN1_uc003kob.1_Missense_Mutation_p.D352Y|GIN1_uc003koc.1_3'UTR	NM_017676	NP_060146	Q9NXP7	GIN1_HUMAN	zinc finger, H2C2 domain containing	499					DNA integration		DNA binding			ovary(1)|skin(1)	2		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		GAACTATGATCGTCTATCAAT	0.318													33	53					3.80469e-20	5.81318e-20	1	0
APC	324	broad.mit.edu	37	5	112151205	112151205	+	Missense_Mutation	SNP	G	A	A	rs149154604		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:112151205G>A	uc010jby.2	+	9	1228	c.848G>A	c.(847-849)CGA>CAA	p.R283Q	APC_uc011cvt.1_Missense_Mutation_p.R265Q|APC_uc003kpz.3_Missense_Mutation_p.R283Q|APC_uc003kpy.3_Missense_Mutation_p.R283Q|APC_uc010jbz.2_5'UTR	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	283	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.R283*(7)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TCAACTACACGAATGGACCAT	0.383		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			17	31					0	0	0	0
KCNN2	3781	broad.mit.edu	37	5	113831815	113831815	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:113831815G>T	uc003kqo.2	+	8	2133	c.1676G>T	c.(1675-1677)CGG>CTG	p.R559L	KCNN2_uc003kqp.2_Missense_Mutation_p.R211L|KCNN2_uc010jcg.2_RNA|uc003kqr.1_RNA	NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	559						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		GAGCGGTCCCGGTCCTCGTCC	0.512													31	74					2.08457e-15	2.98035e-15	1	0
PCDHB15	56121	broad.mit.edu	37	5	140627413	140627413	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:140627413C>A	uc003lje.2	+	1	2267	c.2267C>A	c.(2266-2268)ACG>AAG	p.T756K		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	756	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTGTGTCTGACGGGAGGCTCT	0.517													71	120					4.98182e-18	7.42062e-18	1	0
PCDHGA2	56113	broad.mit.edu	37	5	140718609	140718609	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:140718609G>T	uc003ljk.1	+	1	256	c.71G>T	c.(70-72)TGG>TTG	p.W24L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.W24L	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	24					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGACCCTGTGGGAGGCCAGG	0.577											OREG0016854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	42					1.67942e-08	2.1662e-08	1	0
PCDHGB3	56102	broad.mit.edu	37	5	140751081	140751081	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:140751081C>A	uc003ljw.1	+	1	1120	c.1120C>A	c.(1120-1122)CTA>ATA	p.L374I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.L374I|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	374	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACACATGATCTAGATTCTGG	0.423													7	24					0.00198382	0.00238594	1	0
PCDHGA9	56107	broad.mit.edu	37	5	140784798	140784798	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:140784798C>A	uc003lkh.1	+	1	2279	c.2279C>A	c.(2278-2280)ACC>AAC	p.T760N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.T760N|PCDHGB6_uc003lki.1_5'Flank|PCDHGB6_uc003lkj.1_5'Flank	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	760	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTCCCTCACCGCTGACTCA	0.537													44	83					1.48734e-19	2.26279e-19	1	0
PCDHGB7	56099	broad.mit.edu	37	5	140797510	140797510	+	Silent	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:140797510G>T	uc003lkn.1	+	1	229	c.84G>T	c.(82-84)ACG>ACT	p.T28T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Silent_p.T28T	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	28					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTACCCCACGCTGTGTGAGC	0.527											OREG0016863	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	23					5.50884e-06	6.85715e-06	1	0
PANK3	79646	broad.mit.edu	37	5	168006280	168006280	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:168006280G>A	uc003lzz.1	-	1	309	c.9C>T	c.(7-9)ATC>ATT	p.I3I		NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3	3					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		TGGCATCTTTGATCTTCATGG	0.706													6	9					0	0	0	0
STK10	6793	broad.mit.edu	37	5	171488156	171488156	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr5:171488156C>A	uc003mbo.1	-	14	2499	c.2199G>T	c.(2197-2199)CAG>CAT	p.Q733H		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	733	Potential.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAAGGAGCTCCTGCTTCTTCA	0.617													71	140					9.12251e-31	1.47619e-30	1	0
ABT1	29777	broad.mit.edu	37	6	26597372	26597372	+	Silent	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:26597372G>T	uc003nii.2	+	1	193	c.162G>T	c.(160-162)CCG>CCT	p.P54P		NM_013375	NP_037507	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	54	RRM.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			ovary(1)	1						GCCATATCCCGCCGCGCTTCC	0.612													16	28					2.32078e-09	3.04871e-09	1	0
TRIM39	56658	broad.mit.edu	37	6	30297275	30297275	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:30297275G>A	uc010jrz.2	+	3	493	c.181G>A	c.(181-183)GAG>AAG	p.E61K	HCG18_uc003npx.2_5'Flank|HCG18_uc003npy.2_5'Flank|TRIM39_uc003npz.2_Missense_Mutation_p.E61K|TRIM39_uc003nqb.2_Missense_Mutation_p.E61K|TRIM39_uc003nqc.2_Missense_Mutation_p.E61K|TRIM39_uc010jsa.1_Missense_Mutation_p.E61K	NM_021253	NP_067076	Q9HCM9	TRI39_HUMAN	tripartite motif-containing 39 isoform 1	61	RING-type.				apoptosis	cytosol|mitochondrion	identical protein binding|zinc ion binding			ovary(3)	3						GGAGGACCTAGAGAGGGACTT	0.542													48	83					0	0	0	0
PBX2	5089	broad.mit.edu	37	6	32154610	32154610	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:32154610C>T	uc003oav.1	-	7	1364	c.1093G>A	c.(1093-1095)GAT>AAT	p.D365N	AGER_uc003oar.2_5'Flank|AGER_uc011dpm.1_5'Flank|AGER_uc011dpn.1_5'Flank|AGER_uc003oal.1_5'Flank|AGER_uc010jtv.1_5'Flank|AGER_uc011dpo.1_5'Flank|AGER_uc003oam.1_5'Flank|AGER_uc003oan.1_5'Flank|AGER_uc003oap.1_5'Flank|AGER_uc003oat.1_5'Flank|AGER_uc003oao.1_5'Flank|AGER_uc003oaq.1_5'Flank|AGER_uc010jtw.1_5'Flank|AGER_uc003oas.1_5'Flank|AGER_uc003oau.1_5'Flank|AGER_uc011dpp.1_5'Flank|AGER_uc011dpq.1_5'Flank|AGER_uc011dpr.1_5'Flank|AGER_uc011dps.1_5'Flank	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	365							transcription factor binding			ovary(1)	1						GAATAGGAATCTCCGTTGAGC	0.512													30	55					0	0	0	0
APOBEC2	10930	broad.mit.edu	37	6	41029194	41029194	+	Silent	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:41029194C>A	uc003opl.2	+	2	406	c.259C>A	c.(259-261)CGG>AGG	p.R87R	UNC5CL_uc010jxe.1_Intron|APOBEC2_uc010jxf.2_Intron	NM_006789	NP_006780	Q9Y235	ABEC2_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	87					DNA demethylation|mRNA processing		cytidine deaminase activity|RNA binding|zinc ion binding				0	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCAGGCATCTCGGGGATACCT	0.567													36	82					4.34311e-12	5.92393e-12	1	0
HCRTR2	3062	broad.mit.edu	37	6	55113511	55113511	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:55113511G>T	uc003pcl.2	+	2	613	c.298G>T	c.(298-300)GAT>TAT	p.D100Y	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Missense_Mutation_p.D35Y	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	100	Helical; Name=2; (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TTCTCTGGCTGATGTGCTCGT	0.453													56	102					6.4308e-24	1.00411e-23	1	0
COL19A1	1310	broad.mit.edu	37	6	70856592	70856592	+	Silent	SNP	A	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:70856592A>T	uc003pfc.1	+	26	1929	c.1812A>T	c.(1810-1812)CCA>CCT	p.P604P	COL19A1_uc010kam.1_Silent_p.P500P	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	604	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						CACGTGGGCCAAAGGTATACA	0.323													5	11					0	0	0	0
SPACA1	81833	broad.mit.edu	37	6	88763681	88763681	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:88763681G>C	uc003pmn.2	+	2	343	c.226G>C	c.(226-228)GTC>CTC	p.V76L		NM_030960	NP_112222	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1 precursor	76	Extracellular (Potential).					integral to membrane					0		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		TAGGAATGTCGTCAAAGAAGT	0.348													8	20					0	0	0	0
ROS1	6098	broad.mit.edu	37	6	117683782	117683782	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:117683782C>A	uc003pxp.1	-	21	3564	c.3365G>T	c.(3364-3366)TGC>TTC	p.C1122F	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1122	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GGCAATAAAGCATCTGGGACT	0.408			T	GOPC|ROS1	glioblastoma|NSCLC								12	26					0.00010058	0.000123046	1	0
ROS1	6098	broad.mit.edu	37	6	117709005	117709005	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:117709005G>A	uc003pxp.1	-	13	2151	c.1952C>T	c.(1951-1953)GCA>GTA	p.A651V	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	651	Fibronectin type-III 3.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TGGAGAACTTGCTCTCACAGA	0.488			T	GOPC|ROS1	glioblastoma|NSCLC								50	70					0	0	0	0
THEMIS	387357	broad.mit.edu	37	6	128222065	128222065	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:128222065G>T	uc003qbi.2	-	2	332	c.13C>A	c.(13-15)CTG>ATG	p.L5M	THEMIS_uc011ebt.1_Missense_Mutation_p.L5M|THEMIS_uc010kfb.2_Intron	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	5	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						AATTCTTCCAGTGATAATGCC	0.498													51	69					9.57592e-29	1.5356e-28	1	0
ENPP3	5169	broad.mit.edu	37	6	132061454	132061454	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:132061454C>T	uc003qcu.3	+	25	2738	c.2391C>T	c.(2389-2391)TGC>TGT	p.C797C	ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Silent_p.C797C	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	797	Extracellular (Potential).|Nuclease.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		CGGAAAACTGCCCTGGGTGGC	0.512													31	50					0	0	0	0
KIAA1244	57221	broad.mit.edu	37	6	138601217	138601217	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:138601217G>A	uc003qhu.2	+	14	2377	c.2377G>A	c.(2377-2379)GTG>ATG	p.V793M		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	793	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CTACCATCAGGTGCTCGACAG	0.552													28	29					0	0	0	0
PDE10A	10846	broad.mit.edu	37	6	165957010	165957010	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr6:165957010C>A	uc003qun.2	-	3	325	c.84G>T	c.(82-84)CAG>CAT	p.Q28H	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Translation_Start_Site|PDE10A_uc003quo.2_Missense_Mutation_p.Q38H	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	28					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CATCTAATACCTGGGGGTGAA	0.358													18	28					5.03518e-11	6.76425e-11	1	0
STK31	56164	broad.mit.edu	37	7	23827673	23827673	+	Silent	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:23827673A>G	uc003sws.3	+	21	2629	c.2562A>G	c.(2560-2562)TCA>TCG	p.S854S	STK31_uc003swt.3_Silent_p.S831S|STK31_uc011jze.1_Silent_p.S854S|STK31_uc010kuq.2_Silent_p.S831S|STK31_uc003swv.1_Silent_p.S20S	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	854	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TTCATGGATCACTTCATCAGA	0.353													33	93					0	0	0	0
STK31	56164	broad.mit.edu	37	7	23871841	23871841	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:23871841C>T	uc003sws.3	+	24	2983	c.2916C>T	c.(2914-2916)TTC>TTT	p.F972F	STK31_uc003swt.3_Silent_p.F949F|STK31_uc011jze.1_Silent_p.F949F|STK31_uc010kuq.2_Silent_p.F949F|STK31_uc003swv.1_Silent_p.F138F	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	972	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						CTGAATGTTTCTTGATGCCAA	0.353													68	60					0	0	0	0
BBS9	27241	broad.mit.edu	37	7	33397536	33397536	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:33397536C>A	uc003tdn.1	+	16	2135	c.1622C>A	c.(1621-1623)TCA>TAA	p.S541*	BBS9_uc003tdo.1_Nonsense_Mutation_p.S506*|BBS9_uc003tdp.1_Nonsense_Mutation_p.S536*|BBS9_uc003tdq.1_Nonsense_Mutation_p.S501*|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Nonsense_Mutation_p.S65*|BBS9_uc003tds.1_5'UTR|BBS9_uc011kao.1_Nonsense_Mutation_p.S419*	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	541					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			GGTCAGCCTTCAAAAACTGCA	0.378									Bardet-Biedl_syndrome				8	107					0.000978159	0.00118042	1	0
INHBA	3624	broad.mit.edu	37	7	41739824	41739824	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:41739824G>T	uc003thq.2	-	1	384	c.149C>A	c.(148-150)TCT>TAT	p.S50Y	LOC285954_uc003tht.3_Intron|INHBA_uc003thr.2_Missense_Mutation_p.S50Y|LOC285954_uc003ths.2_Intron	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	50					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						CTCTGGCTGAGAGTTGGGTAC	0.612										TSP Lung(11;0.080)			187	256					7.59282e-81	1.28716e-80	1	0
ZNF716	441234	broad.mit.edu	37	7	57529071	57529071	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:57529071G>T	uc011kdi.1	+	4	1016	c.904G>T	c.(904-906)GGC>TGC	p.G302C		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						TGAAGAATGTGGCAAAGCCTT	0.418													8	16					0.00307968	0.00367908	1	0
ZNF117	51351	broad.mit.edu	37	7	64452342	64452342	+	5'Flank	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:64452342C>A	uc003ttr.2	-						ZNF117_uc011kdr.1_Missense_Mutation_p.D352Y	NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				cctactgggtctgtaaaggcc	0													13	31					3.03607e-14	4.30614e-14	1	0
WBSCR17	64409	broad.mit.edu	37	7	71142291	71142291	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:71142291G>T	uc003tvy.2	+	9	1500	c.1500G>T	c.(1498-1500)CAG>CAT	p.Q500H	WBSCR17_uc003tvz.2_Missense_Mutation_p.Q199H	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	500	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GGGGACCACAGGTAGGAGCTC	0.537													61	111					1.03172e-35	1.70834e-35	1	0
PCLO	27445	broad.mit.edu	37	7	82582174	82582174	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:82582174G>T	uc003uhx.2	-	5	8384	c.8095C>A	c.(8095-8097)CCT>ACT	p.P2699T	PCLO_uc003uhv.2_Missense_Mutation_p.P2699T|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2630					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGCTCTGGAGGAATTGTTATG	0.403													18	47					3.32936e-07	4.23304e-07	1	0
ZNF804B	219578	broad.mit.edu	37	7	88847532	88847532	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:88847532G>T	uc011khi.1	+	2	710	c.172G>T	c.(172-174)GAA>TAA	p.E58*		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	58	C2H2-type.					intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CTTTTACTGTGAATTATGTGA	0.368										HNSCC(36;0.09)			26	29					1.1804e-14	1.68088e-14	1	0
CCDC132	55610	broad.mit.edu	37	7	92887685	92887685	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:92887685G>T	uc003umo.2	+	8	685	c.557G>T	c.(556-558)CGG>CTG	p.R186L	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.R156L|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Intron|CCDC132_uc003umn.2_Missense_Mutation_p.R186L	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	186											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			ACAGATGTACGGTTAAGTGAA	0.299													20	52					3.5997e-14	5.08529e-14	1	0
PPP1R9A	55607	broad.mit.edu	37	7	94791279	94791279	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:94791279G>A	uc003unp.2	+	5	2032	c.1750G>A	c.(1750-1752)GTC>ATC	p.V584I	PPP1R9A_uc010lfj.2_Missense_Mutation_p.V584I|PPP1R9A_uc011kif.1_Missense_Mutation_p.V584I|PPP1R9A_uc003unq.2_Missense_Mutation_p.V584I|PPP1R9A_uc011kig.1_Missense_Mutation_p.V584I	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	584	PDZ.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			CAAGGGCAACGTCAGGTAAAT	0.363										HNSCC(28;0.073)			5	3					0	0	0	0
TRRAP	8295	broad.mit.edu	37	7	98581764	98581764	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:98581764A>G	uc003upp.2	+	60	9292	c.9083A>G	c.(9082-9084)AAT>AGT	p.N3028S	TRRAP_uc011kis.1_Missense_Mutation_p.N2999S|TRRAP_uc003upr.2_Missense_Mutation_p.N2716S	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3028	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CCCAGTTCAAATAACGCTATG	0.448													43	62					0	0	0	0
Unknown	0	broad.mit.edu	37	7	100551864	100551864	+	RNA	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:100551864C>G	uc003uxk.1	+	1		c.1115C>G			uc003uxl.1_Silent_p.L105L					Homo sapiens MUC3B mRNA for intestinal mucin, partial cds.																		AAACTTCACTCACATCTACAA	0.438													56	515					0	0	0	0
MET	4233	broad.mit.edu	37	7	116339752	116339752	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:116339752A>G	uc003vij.2	+	2	801	c.614A>G	c.(613-615)TAT>TGT	p.Y205C	MET_uc010lkh.2_Missense_Mutation_p.Y205C|MET_uc011knc.1_Missense_Mutation_p.Y205C|MET_uc011knd.1_Missense_Mutation_p.Y205C|MET_uc011kne.1_Missense_Mutation_p.Y205C|MET_uc011knf.1_Missense_Mutation_p.Y205C|MET_uc011kng.1_Missense_Mutation_p.Y205C|MET_uc011knh.1_Missense_Mutation_p.Y205C|MET_uc011kni.1_Missense_Mutation_p.Y205C|MET_uc003vii.1_Missense_Mutation_p.Y224C|MET_uc010lkg.2_Missense_Mutation_p.Y205C|MET_uc011kmz.1_Missense_Mutation_p.Y205C|MET_uc011kna.1_Missense_Mutation_p.Y205C|MET_uc011knb.1_Missense_Mutation_p.Y205C	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	205	Extracellular (Potential).|Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AATTCTTCTTATTTCCCAGAT	0.418			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				67	89					0	0	0	0
Unknown	0	broad.mit.edu	37	7	124116548	124116548	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:124116548G>C	uc011kod.1	+	1	124	c.124G>C	c.(124-126)GTG>CTG	p.V42L		NM_001085395	NP_001078864			RecName: Full=Putative RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like protein 2;          Short=CTD phosphatase SSU72-like protein 2;          EC=3.1.3.16;																		TGAATCTCATGTGAGGCTACC	0.478													68	103					0	0	0	0
GRM8	2918	broad.mit.edu	37	7	126544151	126544151	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:126544151T>C	uc003vlr.2	-	4	1204	c.893A>G	c.(892-894)AAC>AGC	p.N298S	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.N298S|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Missense_Mutation_p.N19S	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	298	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CCCACTTTGGTTTAGTTTTTT	0.368										HNSCC(24;0.065)			42	60					0	0	0	0
MGAM	8972	broad.mit.edu	37	7	141755884	141755884	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:141755884A>C	uc003vwy.2	+	29	3622	c.3568A>C	c.(3568-3570)AGC>CGC	p.S1190R		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1190	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCTGCTGAACAGCAATGCCAT	0.512													8	3					0	0	0	0
GALNTL5	168391	broad.mit.edu	37	7	151699803	151699803	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr7:151699803T>A	uc003wkp.2	+	6	886	c.663T>A	c.(661-663)GAT>GAA	p.D221E	GALNTL5_uc003wkq.2_5'UTR|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Missense_Mutation_p.D110E	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	221	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		CCCCAGGGGATGTTCTGGTGT	0.498													25	12					0	0	0	0
MSC	9242	broad.mit.edu	37	8	72754902	72754902	+	Silent	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:72754902G>T	uc003xyx.1	-	2	933	c.615C>A	c.(613-615)ACC>ACA	p.T205T	uc011lff.1_5'Flank|uc003xyy.2_5'Flank	NM_005098	NP_005089	O60682	MUSC_HUMAN	musculin	205					transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			CGATTTAAGCGGTGGTTCCAC	0.493													200	317					3.50731e-122	6.03189e-122	1	0
PSKH2	85481	broad.mit.edu	37	8	87060915	87060915	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:87060915C>G	uc011lfy.1	-	3	934	c.934G>C	c.(934-936)GGC>CGC	p.G312R		NM_033126	NP_149117	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	312	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|lung(2)|ovary(1)	5			STAD - Stomach adenocarcinoma(118;0.129)			AGGGCCTGGCCAGCTGACATG	0.512													36	49					0	0	0	0
CDH17	1015	broad.mit.edu	37	8	95174380	95174380	+	Silent	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:95174380G>T	uc003ygh.2	-	11	1418	c.1293C>A	c.(1291-1293)ACC>ACA	p.T431T	CDH17_uc011lgo.1_Silent_p.T217T|CDH17_uc011lgp.1_Silent_p.T431T	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	431	Extracellular (Potential).|Cadherin 4.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CAAAACAAAGGGTCTTGAAAT	0.313													13	30					6.72482e-11	9.00014e-11	1	0
PGCP	10404	broad.mit.edu	37	8	97978226	97978226	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:97978226G>A	uc003yhw.2	+	5	1079	c.913G>A	c.(913-915)GGT>AGT	p.G305S	PGCP_uc010mbe.2_Missense_Mutation_p.G305S	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	305					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					GGATGATGGCGGTGGAGCCTT	0.378													3	56					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110451290	110451290	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:110451290G>A	uc003yne.2	+	32	4029	c.3925G>A	c.(3925-3927)GAA>AAA	p.E1309K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1309	Extracellular (Potential).|IPT/TIG 6.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TATCTATGTAGAAGTCAGAAA	0.398										HNSCC(38;0.096)			64	106					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110476802	110476802	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:110476802C>A	uc003yne.2	+	49	7845	c.7741C>A	c.(7741-7743)CAC>AAC	p.H2581N		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2581	Extracellular (Potential).|PbH1 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGGTGGCACTCACTTTGGCTT	0.463										HNSCC(38;0.096)			24	35					2.21704e-12	3.04735e-12	1	0
CSMD3	114788	broad.mit.edu	37	8	113246662	113246662	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:113246662G>T	uc003ynu.2	-	68	10831	c.10672C>A	c.(10672-10674)CTT>ATT	p.L3558I	CSMD3_uc003yns.2_Missense_Mutation_p.L2760I|CSMD3_uc003ynt.2_Missense_Mutation_p.L3518I|CSMD3_uc011lhx.1_Missense_Mutation_p.L3389I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3558	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACTTTAATAAGATATATGCGT	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			50	95					1.4374e-25	2.26422e-25	1	0
CSMD3	114788	broad.mit.edu	37	8	113697930	113697930	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:113697930C>A	uc003ynu.2	-	15	2346	c.2187G>T	c.(2185-2187)ATG>ATT	p.M729I	CSMD3_uc003yns.2_Missense_Mutation_p.M1I|CSMD3_uc003ynt.2_Missense_Mutation_p.M689I|CSMD3_uc011lhx.1_Missense_Mutation_p.M625I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	729	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GAACTGTTCCCATTGGTGCAG	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			27	64					1.74197e-06	2.1836e-06	1	0
ZHX2	22882	broad.mit.edu	37	8	123965602	123965602	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:123965602T>C	uc003ypk.1	+	3	2419	c.1852T>C	c.(1852-1854)TCC>CCC	p.S618P		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	618						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			CGACCAGCTCTCCGGTGCCCA	0.532													25	52					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139151251	139151251	+	Silent	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:139151251G>C	uc003yuy.2	-	18	4050	c.3879C>G	c.(3877-3879)CTC>CTG	p.L1293L	FAM135B_uc003yux.2_Silent_p.L1194L|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1293										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTAGTTGGTAGAGGAAACATT	0.438										HNSCC(54;0.14)			12	127					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139165165	139165165	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:139165165C>A	uc003yuy.2	-	13	1724	c.1553G>T	c.(1552-1554)TGT>TTT	p.C518F	FAM135B_uc003yux.2_Missense_Mutation_p.C419F|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.C80F|FAM135B_uc003yvb.2_Missense_Mutation_p.C80F	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	518										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCCAGTCCAACATTCATCTTC	0.463										HNSCC(54;0.14)			41	165					2.24893e-16	3.26784e-16	1	0
CYP11B2	1585	broad.mit.edu	37	8	143994844	143994844	+	Silent	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:143994844C>A	uc003yxk.1	-	6	981	c.978G>T	c.(976-978)ACG>ACT	p.T326T		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	326					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GCTCAAAGAGCGTCATCAGCA	0.622									Familial_Hyperaldosteronism_type_I				27	151					3.73148e-12	5.10925e-12	1	0
NAPRT1	93100	broad.mit.edu	37	8	144658323	144658323	+	Silent	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr8:144658323C>A	uc003yym.3	-	8	1057	c.1032G>T	c.(1030-1032)GTG>GTT	p.V344V	NAPRT1_uc003yyn.3_Silent_p.V344V|NAPRT1_uc011lkh.1_Silent_p.V344V|NAPRT1_uc003yyo.3_Silent_p.V344V	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	344					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CCAGCCAGGGCACCTGGAACC	0.667													20	34					7.41877e-09	9.6743e-09	1	0
DENND4C	55667	broad.mit.edu	37	9	19316463	19316463	+	Silent	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:19316463G>T	uc003znq.2	+	7	861	c.828G>T	c.(826-828)CCG>CCT	p.P276P	DENND4C_uc011lnc.1_5'UTR	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	276						integral to membrane				ovary(1)|skin(1)	2						CCAAAAAGCCGTGCAAAAATC	0.328													11	2					7.03913e-09	9.21297e-09	1	0
FAM75A6	389730	broad.mit.edu	37	9	43626706	43626706	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:43626706T>A	uc011lrb.1	-	4	2010	c.1981A>T	c.(1981-1983)AGG>TGG	p.R661W		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	661						integral to membrane					0						CACAGGTCCCTCTCTAGCTGG	0.562													71	13					0	0	0	0
PGM5	5239	broad.mit.edu	37	9	71098829	71098829	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:71098829G>T	uc004agr.2	+	9	1573	c.1344G>T	c.(1342-1344)AGG>AGT	p.R448S		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	448					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						ATATCATGAGGGACCTGGAGG	0.507													29	57					7.38237e-10	9.73379e-10	1	0
Unknown	0	broad.mit.edu	37	9	74622998	74622998	+	RNA	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:74622998G>T	uc011lsc.1	-	1		c.55C>A				NR_024392				Homo sapiens heat shock 27kDa protein-like 2 pseudogene (HSPBL2), non-coding RNA.																		GTGTATTTCCGCGTGAAGCAC	0.557													4	4					2.56e-06	3.19775e-06	1	0
IARS	3376	broad.mit.edu	37	9	95009669	95009669	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:95009669G>T	uc004art.1	-	26	3038	c.2781C>A	c.(2779-2781)TTC>TTA	p.F927L	IARS_uc004ars.1_Missense_Mutation_p.F772L|IARS_uc004aru.3_Missense_Mutation_p.F927L|IARS_uc010mqr.2_Missense_Mutation_p.F817L|IARS_uc010mqt.2_Missense_Mutation_p.F150L	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	927					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	CAGTCTTCTGGAACTGCTCCA	0.473													24	53					2.24059e-21	3.45304e-21	1	0
LOC441454	441454	broad.mit.edu	37	9	99672508	99672508	+	RNA	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:99672508G>C	uc011luq.1	+	1		c.1152G>C				NR_028350				Homo sapiens prothymosin, alpha pseudogene (LOC441454), non-coding RNA.												0						GGCTGACAAGGAGGTagatga	0.294													4	14					0	0	0	0
BAAT	570	broad.mit.edu	37	9	104133542	104133542	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:104133542G>A	uc010mtd.2	-	2	254	c.145C>T	c.(145-147)CAC>TAC	p.H49Y	BAAT_uc004bbd.3_Missense_Mutation_p.H49Y	NM_001127610	NP_001121082	Q14032	BAAT_HUMAN	bile acid Coenzyme A: amino acid	49					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			ovary(1)|lung(1)|skin(1)	3		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	GCCCTATAGTGGGCTTGAGAA	0.488													33	68					0	0	0	0
OR1N2	138882	broad.mit.edu	37	9	125315511	125315511	+	Silent	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:125315511G>C	uc011lyx.1	+	1	63	c.63G>C	c.(61-63)GTG>GTC	p.V21V		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						CAGGCAGAGTGAACCAAACCA	0.423													39	59					0	0	0	0
SDCCAG3	10807	broad.mit.edu	37	9	139301763	139301763	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:139301763G>A	uc004chi.2	-	5	858	c.653C>T	c.(652-654)CCG>CTG	p.P218L	SDCCAG3_uc004chj.2_Missense_Mutation_p.P195L|SDCCAG3_uc004chk.2_Missense_Mutation_p.P145L	NM_001039707	NP_001034796	Q96C92	SDCG3_HUMAN	serologically defined colon cancer antigen 3	218						cytoplasm					0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		CAGCTCCGACGGGGTGGAGAA	0.657													11	8					0	0	0	0
MAMDC4	158056	broad.mit.edu	37	9	139754408	139754408	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:139754408G>A	uc004cjs.2	+	26	3314	c.3264G>A	c.(3262-3264)GTG>GTA	p.V1088V	MAMDC4_uc011mej.1_Silent_p.V425V	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	1167	Helical; (Potential).				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		TGCTCCTGGTGCTGCTGGGAC	0.627													24	29					0	0	0	0
NELF	26012	broad.mit.edu	37	9	140346851	140346851	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:140346851C>G	uc004cna.2	-	12	1434	c.1202G>C	c.(1201-1203)GGA>GCA	p.G401A	C9orf167_uc011mew.1_Intron|NELF_uc011mex.1_Missense_Mutation_p.G198A|NELF_uc010nci.2_Missense_Mutation_p.G145A|NELF_uc011mey.1_RNA|NELF_uc011mez.1_Missense_Mutation_p.G378A|NELF_uc004cmz.2_Missense_Mutation_p.G399A|NELF_uc004cnc.2_Missense_Mutation_p.G376A|NELF_uc004cnb.2_Missense_Mutation_p.G371A	NM_001130969	NP_001124441	Q6X4W1	NELF_HUMAN	nasal embryonic LHRH factor isoform a	401						nucleus|plasma membrane					0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000222)|Epithelial(140;0.000888)		GATCTTGGCTCCCTTGTGGTA	0.617													59	121					0	0	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070139	141070139	+	Missense_Mutation	SNP	C	T	T	rs143443709	by1000genomes	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:141070139C>T	uc004com.2	+	3	298	c.37C>T	c.(37-39)CTC>TTC	p.L13F	TUBBP5_uc010ncq.2_Missense_Mutation_p.L127F					RecName: Full=Putative tubulin beta-4q chain;												0						CGGGCAGGTCCTCAGGCCAGA	0.667													5	88					0	0	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071110	141071110	+	Silent	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:141071110A>G	uc004com.2	+	4	774	c.513A>G	c.(511-513)CCA>CCG	p.P171P	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TGCGCTTCCCAGGCCAGCTGA	0.597													3	48					0	0	0	0
HDHD1A	8226	broad.mit.edu	37	X	7023726	7023726	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:7023726T>C	uc004crv.2	-	2	292	c.215A>G	c.(214-216)GAG>GGG	p.E72G	HDHD1A_uc011mhm.1_Missense_Mutation_p.E95G|HDHD1A_uc011mhn.1_Intron|HDHD1A_uc010ndl.2_Missense_Mutation_p.E72G|HDHD1A_uc011mho.1_Missense_Mutation_p.E72G	NM_012080	NP_036212	Q08623	HDHD1_HUMAN	haloacid dehalogenase-like hydrolase domain	72					nucleotide metabolic process		metal ion binding|phosphatase activity				0		Colorectal(8;0.0114)|Medulloblastoma(8;0.184)				CACCAGCTCCTCTTTGGACAT	0.502													16	0					0	0	0	0
CNKSR2	22866	broad.mit.edu	37	X	21627262	21627262	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:21627262C>G	uc004czx.1	+	20	2255	c.2219C>G	c.(2218-2220)TCT>TGT	p.S740C	CNKSR2_uc004czw.2_Missense_Mutation_p.S740C|CNKSR2_uc011mjn.1_Missense_Mutation_p.S691C|CNKSR2_uc011mjo.1_Missense_Mutation_p.S710C|CNKSR2_uc004czy.2_Missense_Mutation_p.S332C	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	740					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						CAGTCTCAGTCTTCTCATGAG	0.517													34	10					0	0	0	0
YY2	404281	broad.mit.edu	37	X	21869684	21869684	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:21869684A>T	uc010nfq.2	+	4	693	c.496A>T	c.(496-498)ATT>TTT	p.I166F	MBTPS2_uc004dae.2_Missense_Mutation_p.I166F|MBTPS2_uc010nfr.2_5'Flank|MBTPS2_uc004dab.2_Missense_Mutation_p.I166F	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	Error:Variant_position_missing_in_O15391_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GGCAGTTCTCATTAGTGGTGT	0.373													5	78					0	0	0	0
DMD	1756	broad.mit.edu	37	X	32328320	32328320	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:32328320G>A	uc004dda.1	-	42	6240	c.5996C>T	c.(5995-5997)ACT>ATT	p.T1999I	DMD_uc004dcw.2_Missense_Mutation_p.T655I|DMD_uc004dcx.2_Missense_Mutation_p.T658I|DMD_uc004dcz.2_Missense_Mutation_p.T1876I|DMD_uc004dcy.1_Missense_Mutation_p.T1995I|DMD_uc004ddb.1_Missense_Mutation_p.T1991I|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1999					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGTCAAATAAGTAGAAGGCAC	0.393													21	7					0	0	0	0
DMD	1756	broad.mit.edu	37	X	32404497	32404497	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:32404497G>T	uc004dda.1	-	33	4848	c.4604C>A	c.(4603-4605)ACG>AAG	p.T1535K	DMD_uc004dcw.2_Missense_Mutation_p.T191K|DMD_uc004dcx.2_Missense_Mutation_p.T194K|DMD_uc004dcz.2_Missense_Mutation_p.T1412K|DMD_uc004dcy.1_Missense_Mutation_p.T1531K|DMD_uc004ddb.1_Missense_Mutation_p.T1527K|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1535	Spectrin 10.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGGATTTTCCGTCTGCTTTTT	0.383													49	13					2.43139e-17	3.56204e-17	1	0
KDM6A	7403	broad.mit.edu	37	X	44938390	44938390	+	Splice_Site	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:44938390G>C	uc004dge.3	+	20	3314	c.2939_splice	c.e20-1	p.D980_splice	KDM6A_uc010nhk.2_Splice_Site_p.D946_splice|KDM6A_uc011mkz.1_Splice_Site_p.D1032_splice|KDM6A_uc011mla.1_Splice_Site_p.D935_splice|KDM6A_uc011mlb.1_Splice_Site_p.D987_splice|KDM6A_uc011mlc.1_Splice_Site_p.D684_splice|KDM6A_uc011mld.1_Splice_Site_p.D619_splice	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TATTCATGAAGACCTGGGACT	0.328			D|N|F|S		renal|oesophageal SCC|MM								11	1					0	0	0	0
DRP2	1821	broad.mit.edu	37	X	100494001	100494001	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:100494001C>T	uc004egz.2	+	6	839	c.470C>T	c.(469-471)CCC>CTC	p.P157L	DRP2_uc011mrh.1_Missense_Mutation_p.P79L	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	157	Spectrin 1.				central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						TCTCGGGGCCCCTACATCTAT	0.463													58	16					0	0	0	0
CAPN6	827	broad.mit.edu	37	X	110491846	110491846	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:110491846T>G	uc004epc.1	-	10	1603	c.1435A>C	c.(1435-1437)ACC>CCC	p.T479P	CAPN6_uc011msu.1_Missense_Mutation_p.T224P	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	479	Domain III.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						AACTCGCTGGTGCGACCATGC	0.502													15	4					0	0	0	0
ALG13	79868	broad.mit.edu	37	X	110924494	110924494	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:110924494C>T	uc011msy.1	+	1	82	c.48C>T	c.(46-48)CTC>CTT	p.L16L	ALG13_uc004epi.1_Silent_p.L16L|ALG13_uc011msw.1_5'UTR|ALG13_uc011msx.1_5'UTR|ALG13_uc011msz.1_5'UTR|ALG13_uc011mta.1_5'UTR|ALG13_uc011mtb.1_5'UTR			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	16					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						TTGACGACCTCATTGCGTGTG	0.632													123	30					0	0	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795413	142795413	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:142795413G>T	uc004fbz.2	-	2	1019	c.265C>A	c.(265-267)CTA>ATA	p.L89I		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	89										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GCTGAGTCTAGGCCTTCGTCC	0.488													252	73					9.62967e-114	1.64816e-113	1	0
AFF2	2334	broad.mit.edu	37	X	148072769	148072769	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrX:148072769G>T	uc004fcp.2	+	21	4322	c.3843G>T	c.(3841-3843)ATG>ATT	p.M1281I	AFF2_uc004fcq.2_Missense_Mutation_p.M1271I|AFF2_uc004fcr.2_Missense_Mutation_p.M1242I|AFF2_uc011mxb.1_Missense_Mutation_p.M1246I|AFF2_uc004fcs.2_Missense_Mutation_p.M1246I|AFF2_uc011mxc.1_Missense_Mutation_p.M922I	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1281					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					ACACGCTGATGGGGCCTCTGA	0.493													62	18					2.02796e-37	3.38945e-37	1	0
PRAMEF10	343071	broad.mit.edu	37	1	12955542	12955542	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:12955542A>C	uc001auo.2	-	2	210	c.137T>G	c.(136-138)ATG>AGG	p.M46R		NM_001039361	NP_001034450	O60809	PRA10_HUMAN	PRAME family member 10	46											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AAAACGTCTCATGCTGAAGGC	0.572													33	21					0	0	0	0
DDI2	84301	broad.mit.edu	37	1	15956910	15956910	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:15956910C>T	uc001awx.1	+	3	455	c.359C>T	c.(358-360)TCA>TTA	p.S120L	DDI2_uc001aww.2_Missense_Mutation_p.S120L|DDI2_uc009voj.1_5'UTR	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	120					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		CAGTCCCACTCATCTCCTGGA	0.542													33	15					0	0	0	0
CLCNKB	1188	broad.mit.edu	37	1	16380200	16380200	+	Silent	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:16380200A>G	uc001axw.3	+	16	1769	c.1689A>G	c.(1687-1689)CCA>CCG	p.P563P	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Silent_p.P563P|CLCNKB_uc001axy.3_Silent_p.P394P	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	563	CBS 1.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		AGGACATGCCACTGGAGGAGG	0.632													15	15					0	0	0	0
PABPC4	8761	broad.mit.edu	37	1	40030930	40030930	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:40030930C>A	uc010oiv.1	-	8	1991	c.1093G>T	c.(1093-1095)GTT>TTT	p.V365F	PABPC4_uc001cdl.2_Missense_Mutation_p.V365F|PABPC4_uc001cdm.2_Missense_Mutation_p.V365F	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	365	RRM 4.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GCCAGGGCAACATATAGTGGC	0.507													30	17					8.4185e-14	1.14439e-13	1	0
STIL	6491	broad.mit.edu	37	1	47717390	47717390	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:47717390G>A	uc001crc.1	-	17	3437	c.3282C>T	c.(3280-3282)AGC>AGT	p.S1094S	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Silent_p.S1048S|STIL_uc010omo.1_Silent_p.S1077S|STIL_uc001crd.1_Silent_p.S1095S|STIL_uc001cre.1_Silent_p.S1094S	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	1094					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TATGGAGAAGGCTGAATGGGT	0.373													69	42					0	0	0	0
C1orf83	127428	broad.mit.edu	37	1	54562036	54562036	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:54562036C>T	uc001cwt.1	+	5	717	c.517C>T	c.(517-519)CGG>TGG	p.R173W	C1orf83_uc001cwu.1_RNA	NM_153035	NP_694580	Q96MN5	TEAN2_HUMAN	hypothetical protein LOC127428	173	TFIIS central.				transcription, DNA-dependent	nucleus	DNA binding				0						GCCGTACCGGCGGACGGTGAG	0.512													38	20					0	0	0	0
LEPR	3953	broad.mit.edu	37	1	66081724	66081724	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:66081724C>T	uc001dci.2	+	15	2231	c.2029C>T	c.(2029-2031)CAG>TAG	p.Q677*	LEPR_uc001dcg.2_Nonsense_Mutation_p.Q677*|LEPR_uc001dch.2_Nonsense_Mutation_p.Q677*|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Nonsense_Mutation_p.Q677*|LEPR_uc001dck.2_Nonsense_Mutation_p.Q677*	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	677	Extracellular (Potential).|Fibronectin type-III 3.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GTGCAGTGTTCAGAGATATGT	0.393													15	15					0	0	0	0
C1orf173	127254	broad.mit.edu	37	1	75037100	75037100	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:75037100C>A	uc001dgg.2	-	14	4513	c.4294G>T	c.(4294-4296)GGC>TGC	p.G1432C		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1432	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCTGGAGTGCCCACCCCAGCC	0.612													58	33					2.43698e-19	3.59351e-19	1	0
AGL	178	broad.mit.edu	37	1	100327061	100327061	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:100327061T>C	uc001dsi.1	+	3	485	c.85T>C	c.(85-87)TAT>CAT	p.Y29H	AGL_uc001dsj.1_Missense_Mutation_p.Y29H|AGL_uc001dsk.1_Missense_Mutation_p.Y29H|AGL_uc001dsl.1_Missense_Mutation_p.Y29H|AGL_uc001dsm.1_Missense_Mutation_p.Y13H|AGL_uc001dsn.1_Missense_Mutation_p.Y12H	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	29	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TTATTTAGGGTATGAGCTACA	0.308													12	9					0	0	0	0
MAGI3	260425	broad.mit.edu	37	1	114216018	114216018	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:114216018G>A	uc001edk.2	+	19	3301	c.3120G>A	c.(3118-3120)GAG>GAA	p.E1040E	MAGI3_uc001edh.3_Silent_p.E1065E|MAGI3_uc001edi.3_Silent_p.E1040E|MAGI3_uc010owm.1_Silent_p.E1065E|MAGI3_uc001edj.2_Silent_p.E761E	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1065	PDZ 6.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGGGAAGGAGTACAACATGG	0.488													64	39					0	0	0	0
MTMR11	10903	broad.mit.edu	37	1	149905389	149905389	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:149905389C>T	uc001etl.3	-	10	1146	c.895G>A	c.(895-897)GAT>AAT	p.D299N	MTMR11_uc001etm.1_Missense_Mutation_p.D227N|MTMR11_uc010pbm.1_Missense_Mutation_p.D271N|MTMR11_uc010pbn.1_Missense_Mutation_p.D141N	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	299	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			AGGACAACATCTGAATGCCCA	0.547													31	105					0	0	0	0
RFX5	5993	broad.mit.edu	37	1	151315026	151315026	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:151315026G>C	uc001exv.1	-	11	1701	c.1487C>G	c.(1486-1488)TCA>TGA	p.S496*	RFX5_uc001exw.1_Nonsense_Mutation_p.S496*|RFX5_uc009wmr.1_Nonsense_Mutation_p.S496*|RFX5_uc010pcx.1_Nonsense_Mutation_p.S456*	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5	496						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGGTAACCTTGAGGACTGGGC	0.577													83	194					0	0	0	0
NUP210L	91181	broad.mit.edu	37	1	154034118	154034118	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:154034118C>T	uc001fdw.2	-	18	2659	c.2587G>A	c.(2587-2589)GGG>AGG	p.G863R	NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Missense_Mutation_p.G863R	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	863						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AGTACAGTCCCTTTTATCTGA	0.338													27	53					0	0	0	0
OR6K2	81448	broad.mit.edu	37	1	158669597	158669597	+	Missense_Mutation	SNP	C	G	G	rs141159720	byFrequency	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:158669597C>G	uc001fsu.1	-	1	846	c.846G>C	c.(844-846)TTG>TTC	p.L282F		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AGAAGGGAGACAAAACTGCAA	0.403													10	29					0	0	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161022564	161022564	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:161022564G>A	uc001fxl.2	-	7	1034	c.688C>T	c.(688-690)CGA>TGA	p.R230*	ARHGAP30_uc001fxk.2_Nonsense_Mutation_p.R230*|ARHGAP30_uc001fxm.2_Nonsense_Mutation_p.R76*|ARHGAP30_uc009wtx.2_5'UTR|ARHGAP30_uc001fxn.1_Nonsense_Mutation_p.R76*	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	230					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GGAAGCGATCGCCACCCACTC	0.607													27	39					0	0	0	0
DUSP12	11266	broad.mit.edu	37	1	161719654	161719654	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:161719654C>T	uc001gbo.2	+	1	74	c.63C>T	c.(61-63)GTC>GTT	p.V21V	DUSP12_uc001gbp.2_5'UTR	NM_007240	NP_009171	Q9UNI6	DUS12_HUMAN	dual specificity phosphatase 12	21					positive regulation of glucokinase activity	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding			breast(1)	1	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			CCAGCAGAGTCAGCTGTGCCG	0.672													4	16					0	0	0	0
C1orf114	57821	broad.mit.edu	37	1	169390813	169390813	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:169390813C>T	uc001gga.1	-	3	1024	c.856G>A	c.(856-858)GAG>AAG	p.E286K	C1orf114_uc001gfz.1_Missense_Mutation_p.E286K|C1orf114_uc009wvq.1_Missense_Mutation_p.E286K|C1orf114_uc001ggb.2_Missense_Mutation_p.E286K|C1orf114_uc001ggc.1_Missense_Mutation_p.E286K	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	286											0	all_hematologic(923;0.208)					GCCAGCGGCTCTCCTGTTGAT	0.473													53	142					0	0	0	0
PRRX1	5396	broad.mit.edu	37	1	170688866	170688866	+	Splice_Site	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:170688866G>C	uc001ghf.2	+	2	289	c.242_splice	c.e2-1	p.N81_splice	PRRX1_uc001ghe.2_Splice_Site_p.N81_splice	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTCTATTCCAGATGACCAGCT	0.408													14	19					0	0	0	0
BAT2L2	23215	broad.mit.edu	37	1	171509618	171509618	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:171509618G>T	uc010pmg.1	+	16	3273	c.3007G>T	c.(3007-3009)GAA>TAA	p.E1003*	BAT2L2_uc010pmh.1_5'UTR	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	1003							protein C-terminus binding				0						TAACAGAAGGGAAGAAGTTAA	0.413													17	16					1.02788e-11	1.35494e-11	1	0
CACNA1E	777	broad.mit.edu	37	1	181680164	181680164	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:181680164A>G	uc001gow.2	+	8	1295	c.1130A>G	c.(1129-1131)GAG>GGG	p.E377G	CACNA1E_uc009wxs.2_Missense_Mutation_p.E284G	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	377	Cytoplasmic (Potential).|Binding to the beta subunit (By similarity).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CAGCAGATTGAGCGTGAGCTG	0.577													39	98					0	0	0	0
IVNS1ABP	10625	broad.mit.edu	37	1	185276680	185276680	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:185276680G>C	uc001grl.2	-	6	1095	c.472C>G	c.(472-474)CAG>GAG	p.Q158E	IVNS1ABP_uc001grj.2_5'Flank|IVNS1ABP_uc009wyj.2_5'UTR|IVNS1ABP_uc009wyk.2_RNA	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	158	BACK.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						AAATGCTCCTGAATATAAGCA	0.363													25	70					0	0	0	0
HMCN1	83872	broad.mit.edu	37	1	185946936	185946936	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:185946936C>T	uc001grq.1	+	16	2618	c.2389C>T	c.(2389-2391)CAA>TAA	p.Q797*	HMCN1_uc001grr.1_Nonsense_Mutation_p.Q138*	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	797	Ig-like C2-type 5.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AGTTTTCATACAAGAACCTGC	0.343													49	61					0	0	0	0
PRELP	5549	broad.mit.edu	37	1	203452824	203452824	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:203452824G>A	uc001gzs.2	+	2	712	c.512G>A	c.(511-513)CGG>CAG	p.R171Q	PRELP_uc001gzt.2_Missense_Mutation_p.R171Q	NM_002725	NP_002716	P51888	PRELP_HUMAN	proline arginine-rich end leucine-rich repeat	171	LRR 4.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(1)|central_nervous_system(1)|pancreas(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.109)			GCCCTGCCCCGGAACCTGGAG	0.597													5	149					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237660034	237660034	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:237660034G>C	uc001hyl.1	+	20	2305	c.2185G>C	c.(2185-2187)GGC>CGC	p.G729R		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	729	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGGATTTGATGGCCTTCATCT	0.493													65	188					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237865319	237865319	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:237865319T>A	uc001hyl.1	+	66	9529	c.9409T>A	c.(9409-9411)TTA>ATA	p.L3137I	RYR2_uc010pxz.1_Missense_Mutation_p.L92I	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3137					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCTGACTAGCTTATATGCTTT	0.328													32	16					0	0	0	0
FMN2	56776	broad.mit.edu	37	1	240370643	240370643	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:240370643C>T	uc010pyd.1	+	5	2756	c.2531C>T	c.(2530-2532)TCT>TTT	p.S844F	FMN2_uc010pye.1_Missense_Mutation_p.S848F	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	844	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CACGAACACTCTGTTTCCTCT	0.562													73	68					0	0	0	0
RGS7	6000	broad.mit.edu	37	1	240964780	240964780	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:240964780G>C	uc001hyv.2	-	17	1718	c.1388C>G	c.(1387-1389)TCT>TGT	p.S463C	RGS7_uc010pyh.1_Intron|RGS7_uc010pyj.1_Intron|RGS7_uc001hyu.2_Intron|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Intron|RGS7_uc001hyt.2_Missense_Mutation_p.S295C	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	463					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TTTTTCAAAAGATGTTCTGCG	0.239													10	18					0	0	0	0
KIF26B	55083	broad.mit.edu	37	1	245849620	245849620	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:245849620G>T	uc001ibf.1	+	12	3775	c.3335G>T	c.(3334-3336)GGC>GTC	p.G1112V	KIF26B_uc001ibg.1_Missense_Mutation_p.G730V|KIF26B_uc001ibh.1_Missense_Mutation_p.G354V	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1112					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AAGGATTCCGGCGTGGCGTCT	0.612													56	125					3.31993e-32	5.2755e-32	1	0
OR2T1	26696	broad.mit.edu	37	1	248569514	248569514	+	Silent	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:248569514C>A	uc010pzm.1	+	1	219	c.219C>A	c.(217-219)ACC>ACA	p.T73T		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	73	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GAAAGGAAACCTCAGGTCTTA	0.423													83	73					1.20873e-29	1.89477e-29	1	0
OR2T3	343173	broad.mit.edu	37	1	248637225	248637225	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:248637225C>T	uc001iel.1	+	1	574	c.574C>T	c.(574-576)CTC>TTC	p.L192F		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCTGCTGAAGCTCTCCTGCTC	0.517													192	155					0	0	0	0
OR2T3	343173	broad.mit.edu	37	1	248637239	248637239	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:248637239C>G	uc001iel.1	+	1	588	c.588C>G	c.(586-588)GAC>GAG	p.D196E		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCTGCTCTGACGTCTCCCTCT	0.522													107	273					0	0	0	0
FAM188A	80013	broad.mit.edu	37	10	15828592	15828592	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr10:15828592C>A	uc001iod.1	-	13	1305	c.1084G>T	c.(1084-1086)GGC>TGC	p.G362C	FAM188A_uc001ioe.1_Missense_Mutation_p.G189C	NM_024948	NP_079224	Q9H8M7	F188A_HUMAN	chromosome 10 open reading frame 97	362					apoptosis	nucleus	calcium ion binding			ovary(1)	1						AGAAATGGGCCCAATAATATG	0.338													38	77					6.97489e-18	1.003e-17	1	0
KIAA1217	56243	broad.mit.edu	37	10	24727394	24727394	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr10:24727394A>G	uc001iru.3	+	5	1235	c.832A>G	c.(832-834)AAT>GAT	p.N278D	KIAA1217_uc001irs.2_Missense_Mutation_p.N198D|KIAA1217_uc001irt.3_Missense_Mutation_p.N278D|KIAA1217_uc010qcy.1_Missense_Mutation_p.N278D|KIAA1217_uc010qcz.1_Missense_Mutation_p.N278D|KIAA1217_uc001irv.1_Missense_Mutation_p.N128D|KIAA1217_uc010qda.1_RNA	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	278					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						AAAAACTATGAATGGAGACAT	0.403													43	56					0	0	0	0
ZNF37B	100129482	broad.mit.edu	37	10	43015849	43015849	+	RNA	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr10:43015849G>A	uc001jab.3	-	5		c.3351C>T			ZNF37B_uc001jac.3_RNA|ZNF37B_uc001jaa.3_RNA					Homo sapiens cDNA: FLJ23327 fis, clone HEP12630, highly similar to HSZNF37 Homo sapiens ZNF37A mRNA for zinc finger protein.												0						TCTCTCCCCTGTGTGAATTCT	0.413													16	27					0	0	0	0
PPYR1	5540	broad.mit.edu	37	10	47087602	47087602	+	Silent	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr10:47087602C>A	uc001jee.2	+	3	1238	c.819C>A	c.(817-819)GCC>GCA	p.A273A	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Silent_p.A273A	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	273	Helical; Name=6; (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						TGGTGGTGGCCTTTGCTGTGC	0.587													20	87					3.99206e-14	5.44798e-14	1	0
LOC642826	642826	broad.mit.edu	37	10	47207813	47207813	+	RNA	SNP	T	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr10:47207813T>C	uc001jei.2	-	12		c.1586A>G			uc009xnf.2_Missense_Mutation_p.H132R					Homo sapiens cDNA, FLJ99065.												0						TTTACTTACATGGTTTGTACA	0.294													4	20					0	0	0	0
OGDHL	55753	broad.mit.edu	37	10	50945898	50945898	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr10:50945898T>A	uc001jie.2	-	20	2666	c.2524A>T	c.(2524-2526)ATC>TTC	p.I842F	OGDHL_uc009xog.2_Missense_Mutation_p.I869F|OGDHL_uc010qgt.1_Missense_Mutation_p.I785F|OGDHL_uc010qgu.1_Missense_Mutation_p.I633F	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	842					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GGTGTGAAGATAATCAGCTGG	0.617													33	50					0	0	0	0
PCDH15	65217	broad.mit.edu	37	10	56106133	56106133	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr10:56106133C>A	uc001jju.1	-	6	981	c.586G>T	c.(586-588)GAT>TAT	p.D196Y	PCDH15_uc010qhq.1_Missense_Mutation_p.D201Y|PCDH15_uc010qhr.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhs.1_Missense_Mutation_p.D201Y|PCDH15_uc010qht.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhu.1_Missense_Mutation_p.D196Y|PCDH15_uc001jjv.1_Missense_Mutation_p.D174Y|PCDH15_uc010qhv.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhw.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhx.1_Missense_Mutation_p.D196Y|PCDH15_uc010qhy.1_Missense_Mutation_p.D201Y|PCDH15_uc010qhz.1_Missense_Mutation_p.D196Y|PCDH15_uc010qia.1_Missense_Mutation_p.D174Y|PCDH15_uc010qib.1_Missense_Mutation_p.D174Y|PCDH15_uc001jjw.2_Missense_Mutation_p.D196Y	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	196	Extracellular (Potential).|Cadherin 2.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACCGGATCATCTGGATTATAC	0.308										HNSCC(58;0.16)			26	59					1.66031e-10	2.15592e-10	1	0
CCDC6	8030	broad.mit.edu	37	10	61666054	61666054	+	Silent	SNP	A	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr10:61666054A>C	uc001jks.3	-	1	765	c.129T>G	c.(127-129)GGT>GGG	p.G43G		NM_005436	NP_005427	Q16204	CCDC6_HUMAN	coiled-coil domain containing 6	43	Poly-Gly.					cytoplasm|cytoskeleton	SH3 domain binding|structural constituent of cytoskeleton			ovary(3)|breast(1)	4				Kidney(211;0.0597)		CCGACTTCccaccgccgccgc	0.537													11	68					0	0	0	0
GLUD1	2746	broad.mit.edu	37	10	88836358	88836358	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr10:88836358C>T	uc001keh.2	-	2	598	c.501G>A	c.(499-501)CTG>CTA	p.L167L	GLUD1_uc001keg.2_5'UTR|GLUD1_uc010qmp.1_Silent_p.L34L	NM_005271	NP_005262	P00367	DHE3_HUMAN	glutamate dehydrogenase 1 precursor	167					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding				0					L-Glutamic Acid(DB00142)|NADH(DB00157)	TGTATGTCATCAGAGAAGCCA	0.413													25	36					0	0	0	0
PKD2L1	9033	broad.mit.edu	37	10	102050202	102050202	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr10:102050202C>A	uc001kqx.1	-	13	2465	c.2082G>T	c.(2080-2082)GAG>GAT	p.E694D	PKD2L1_uc009xwm.1_Missense_Mutation_p.E647D	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	694	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		CTCTGGCAGCCTCTGGACCCG	0.527													8	23					0.000157383	0.000187566	1	0
WNT8B	7479	broad.mit.edu	37	10	102241771	102241771	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr10:102241771G>A	uc001krb.2	+	5	584	c.470G>A	c.(469-471)CGG>CAG	p.R157Q		NM_003393	NP_003384	Q93098	WNT8B_HUMAN	wingless-type MMTV integration site family,	157					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|determination of dorsal identity|endoderm development|eye development|gastrulation|hypothalamus development|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway|otic placode formation|positive regulation of gene expression|response to estradiol stimulus|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			ovary(1)|breast(1)|large_intestine(1)|skin(1)	4		Colorectal(252;0.117)		Epithelial(162;1.87e-10)|all cancers(201;1.64e-08)		CAGGATGCACGGGCAGCCATG	0.592											OREG0020440	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	48					0	0	0	0
C10orf79	80217	broad.mit.edu	37	10	105893540	105893540	+	Silent	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr10:105893540A>G	uc001kxw.2	-	35	4550	c.4434T>C	c.(4432-4434)ACT>ACC	p.T1478T	C10orf79_uc009xxq.2_Silent_p.T757T	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	1478											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TTTGTCCTTGAGTCTTTAAAA	0.318													15	31					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1263788	1263788	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:1263788C>A	uc009ycr.1	+	47	7883	c.7757C>A	c.(7756-7758)TCC>TAC	p.S2586Y	MUC5B_uc001ltb.2_Missense_Mutation_p.S1896Y	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1893	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCCACCAGCTCCACGGCCACG	0.612													45	81					1.86633e-21	2.81162e-21	1	0
LOC650368	650368	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:3427765G>C	uc010qxs.1	+	9		c.758G>C			LOC650368_uc001lxx.2_RNA|LOC650368_uc001lxy.2_RNA	NR_024248				Homo sapiens cDNA FLJ41654 fis, clone FEBRA2025463, weakly  similar to Homo sapiens HMT-1 mRNA for beta-1,4 mannosyltransferase.												0						CACACGTCCTGCAGTGGCCTG	0.602													4	79					0	0	0	0
OR52L1	338751	broad.mit.edu	37	11	6007529	6007529	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:6007529G>T	uc001mcd.2	-	1	687	c.632C>A	c.(631-633)ACA>AAA	p.T211K		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	211	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCGATTGACTGTGGTTTCTGA	0.493													55	99					5.22555e-25	7.97585e-25	1	0
DCHS1	8642	broad.mit.edu	37	11	6643935	6643935	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:6643935C>T	uc001mem.1	-	21	9382	c.8972G>A	c.(8971-8973)CGG>CAG	p.R2991Q		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	2991	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGTGGCTCCCGGCCCAGTTT	0.642													5	5					0	0	0	0
OR5P2	120065	broad.mit.edu	37	11	7818034	7818034	+	Silent	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:7818034A>G	uc001mfp.1	-	1	456	c.456T>C	c.(454-456)GCT>GCC	p.A152A		NM_153444	NP_703145	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TATAGGAGACAGCAATGAGAA	0.388													31	44					0	0	0	0
ST5	6764	broad.mit.edu	37	11	8737301	8737301	+	Missense_Mutation	SNP	C	T	T	rs35353984		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:8737301C>T	uc001mgt.2	-	6	1880	c.1694G>A	c.(1693-1695)CGG>CAG	p.R565Q	ST5_uc009yfr.2_Missense_Mutation_p.R145Q|ST5_uc001mgu.2_Missense_Mutation_p.R145Q|ST5_uc001mgv.2_Missense_Mutation_p.R565Q|ST5_uc010rbq.1_RNA|ST5_uc010rbp.1_Missense_Mutation_p.R78Q	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	565					positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		TCGTGGCAGCCGGTGGCTCTT	0.617													41	80					0	0	0	0
ANO5	203859	broad.mit.edu	37	11	22301128	22301128	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:22301128G>T	uc001mqi.2	+	22	2876	c.2559G>T	c.(2557-2559)ATG>ATT	p.M853I	ANO5_uc001mqj.2_Missense_Mutation_p.M852I	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	853	Helical; (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TGGCCTGGATGATACCTGATG	0.358													17	37					0.00074312	0.000879612	1	0
LRP4	4038	broad.mit.edu	37	11	46908046	46908046	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:46908046T>C	uc001ndn.3	-	17	2400	c.2254A>G	c.(2254-2256)ATC>GTC	p.I752V		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	752	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		ATTCGACGGATGTCCATCCTT	0.517													25	34					0	0	0	0
OR4X2	119764	broad.mit.edu	37	11	48267430	48267430	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:48267430A>G	uc001ngs.1	+	1	775	c.775A>G	c.(775-777)ATA>GTA	p.I259V		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	259	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CACTCTGCCCATAGACAAGAT	0.512													26	32					0	0	0	0
OR4A47	403253	broad.mit.edu	37	11	48511249	48511249	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:48511249G>T	uc010rhx.1	+	1	905	c.905G>T	c.(904-906)AGA>ATA	p.R302I		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTCTGGAGAAGAGACCTCATA	0.413													28	50					1.77063e-15	2.47462e-15	1	0
OR4C46	119749	broad.mit.edu	37	11	51515722	51515722	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:51515722G>T	uc010ric.1	+	1	441	c.441G>T	c.(439-441)TGG>TGT	p.W147C		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GAGTGGTGTGGATGGGAGGCT	0.463													75	119					1.15098e-32	1.83734e-32	1	0
OR5T3	390154	broad.mit.edu	37	11	56019812	56019812	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:56019812G>C	uc010rjd.1	+	1	137	c.137G>C	c.(136-138)GGC>GCC	p.G46A		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	46	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					ATATTGACAGGCTTCACAGAT	0.373													41	67					0	0	0	0
OR5M1	390168	broad.mit.edu	37	11	56380788	56380788	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:56380788C>T	uc001nja.1	-	1	191	c.191G>A	c.(190-192)GGC>GAC	p.G64D		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GGAGAGGTGGCCAAGGAAGAA	0.468													44	80					0	0	0	0
ACY3	91703	broad.mit.edu	37	11	67410230	67410230	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:67410230G>T	uc001omq.2	-	8	1096	c.925C>A	c.(925-927)CCC>ACC	p.P309T		NM_080658	NP_542389	Q96HD9	ACY3_HUMAN	aspartoacylase 3	309					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	GTCAGCGCGGGCATGGCAGGC	0.587													45	98					4.78724e-31	7.57255e-31	1	0
LRP5	4041	broad.mit.edu	37	11	68154175	68154175	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:68154175G>A	uc001ont.2	+	6	1482	c.1407G>A	c.(1405-1407)GTG>GTA	p.V469V	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	469	LDL-receptor class B 7.|Beta-propeller 2.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						TGCACCCCGTGATGGGGTAAG	0.672													13	27					0	0	0	0
P2RY2	5029	broad.mit.edu	37	11	72946311	72946311	+	Missense_Mutation	SNP	C	G	G	rs145119561	by1000genomes	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:72946311C>G	uc001otj.2	+	3	1440	c.1107C>G	c.(1105-1107)AGC>AGG	p.S369R	P2RY2_uc001otk.2_Missense_Mutation_p.S369R|P2RY2_uc001otl.2_Missense_Mutation_p.S369R	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	369	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	CGGCTGGTAGCGAGAACACTA	0.552													47	35					0	0	0	0
RELT	84957	broad.mit.edu	37	11	73101965	73101965	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:73101965G>T	uc001otv.2	+	4	451	c.286G>T	c.(286-288)GGG>TGG	p.G96W	RELT_uc001otw.2_Missense_Mutation_p.G96W|RELT_uc009yto.1_Missense_Mutation_p.G14W|RELT_uc001otx.2_5'Flank	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	96	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						CTGCTGGCCTGGGTAAGCCAA	0.602													24	19					1.77063e-15	2.47462e-15	1	0
OR2AT4	341152	broad.mit.edu	37	11	74800246	74800246	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:74800246C>G	uc010rro.1	-	1	513	c.513G>C	c.(511-513)ATG>ATC	p.M171I		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGTTATATGCCATCTGGGAGG	0.572													25	9					0	0	0	0
MYO7A	4647	broad.mit.edu	37	11	76916513	76916513	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:76916513C>T	uc001oyb.2	+	40	5759	c.5487C>T	c.(5485-5487)AGC>AGT	p.S1829S	MYO7A_uc001oyc.2_Silent_p.S1791S|MYO7A_uc001oye.2_Intron	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	1829	MyTH4 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						GCAGGTACAGCGAGGAGCGGG	0.677													5	0					0	0	0	0
MMP13	4322	broad.mit.edu	37	11	102818711	102818711	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:102818711C>G	uc001phl.2	-	8	1148	c.1120G>C	c.(1120-1122)GGT>CGT	p.G374R		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	374	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		TTTGGAAGACCCAGTTCAGAT	0.403													21	13					0	0	0	0
GRIA4	2893	broad.mit.edu	37	11	105789531	105789531	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:105789531G>C	uc001pix.2	+	11	1809	c.1363G>C	c.(1363-1365)GCA>CCA	p.A455P	GRIA4_uc001piw.2_Missense_Mutation_p.A455P	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	455	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ATCTGAAATTGCAAAACATAT	0.353													13	5					0	0	0	0
LOC653113	653113	broad.mit.edu	37	12	8384474	8384474	+	RNA	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr12:8384474C>T	uc010sgk.1	-	5		c.1314G>A				NR_024254				Homo sapiens family with sequence similarity 86, member A pseudogene (LOC653113), non-coding RNA.												0						TGGCCAGAAGCTGAAATGACG	0.577													9	24					0	0	0	0
PRB2	653247	broad.mit.edu	37	12	11546873	11546873	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr12:11546873G>T	uc010shk.1	-	3	174	c.139C>A	c.(139-141)CCT>ACT	p.P47T		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGACCTTGAGGTTTGTTGCCT	0.537													144	181					2.60356e-62	4.27376e-62	1	0
FAM60A	58516	broad.mit.edu	37	12	31435799	31435799	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr12:31435799C>T	uc010sjz.1	-	6	752	c.513G>A	c.(511-513)AAG>AAA	p.K171K	FAM60A_uc001rkd.2_Silent_p.K171K|FAM60A_uc010ska.1_Silent_p.K171K|FAM60A_uc001rke.2_Silent_p.K171K|FAM60A_uc010skb.1_RNA|FAM60A_uc001rkc.2_Silent_p.K196K	NM_021238	NP_067061	Q9NP50	FA60A_HUMAN	family with sequence similarity 60, member A	171											0	all_cancers(9;5.22e-13)|all_epithelial(9;4e-13)|all_lung(12;1.2e-11)|Lung NSC(12;2.17e-09)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0207)|Lung SC(12;0.0592)|Esophageal squamous(101;0.162)					CACAACATATCTTCTGTCTAA	0.353													17	29					0	0	0	0
ABCD2	225	broad.mit.edu	37	12	39947723	39947723	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr12:39947723C>G	uc001rmb.2	-	10	2640	c.2214G>C	c.(2212-2214)GAG>GAC	p.E738D		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	738					fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						ATTAAGATGTCTCATCTTCAT	0.323													4	7					0	0	0	0
RACGAP1P	83956	broad.mit.edu	37	12	45459000	45459000	+	RNA	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr12:45459000C>T	uc001rol.2	-	1		c.195G>A				NR_026583				Homo sapiens FKSG42 (FKSG42) mRNA, complete cds.												0						AGTCAGTCCTCTCCCACTTTT	0.448													10	17					0	0	0	0
DUSP6	1848	broad.mit.edu	37	12	89745444	89745444	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr12:89745444C>T	uc001tay.2	-	1	853	c.373G>A	c.(373-375)GAG>AAG	p.E125K	DUSP6_uc001taz.2_Missense_Mutation_p.E125K	NM_001946	NP_001937	Q16828	DUS6_HUMAN	dual specificity phosphatase 6 isoform a	125	Rhodanese.				dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						CGGCAGCCCTCGTCCTTGAGC	0.687													6	2					0	0	0	0
LUM	4060	broad.mit.edu	37	12	91502199	91502199	+	Silent	SNP	G	C	C	rs144214151		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr12:91502199G>C	uc001tbm.2	-	2	947	c.558C>G	c.(556-558)CTC>CTG	p.L186L	LUM_uc001tbn.2_Intron	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	186	LRR 6.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						CAAGGTATTCGAGTGATTTAA	0.433													40	12					0	0	0	0
C12orf51	283450	broad.mit.edu	37	12	112622228	112622228	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr12:112622228G>A	uc009zwc.2	-	54	9294	c.9276C>T	c.(9274-9276)GCC>GCT	p.A3092A		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GCTCGAGGCCGGCAGGCAGCG	0.627													11	1					0	0	0	0
TBX3	6926	broad.mit.edu	37	12	115109999	115109999	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr12:115109999G>A	uc001tvt.1	-	8	2843	c.1879C>T	c.(1879-1881)CCC>TCC	p.P627S	TBX3_uc001tvu.1_Missense_Mutation_p.P607S	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	627	Transcription repression.			SAAASSSVHRHPF -> LRQPQLRCTAPL (in Ref. 1).	anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		TTGAGGAAGGGGTGGCGGTGC	0.682													3	2					0	0	0	0
HNF1A	6927	broad.mit.edu	37	12	121438953	121438953	+	Silent	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr12:121438953C>A	uc001tzg.2	+	10	1877	c.1854C>A	c.(1852-1854)ATC>ATA	p.I618I	HNF1A_uc010szn.1_Silent_p.I625I	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	618			I -> M (in MODY3).		glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ACAGCGTCATCGAGACCTTCA	0.617									Hepatic_Adenoma_Familial_Clustering_of				10	5					1.58986e-06	1.94814e-06	1	0
LOC374491	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	G	G	rs3874227	by1000genomes	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr13:25161397C>G	uc001upm.2	+	8		c.921C>G			LOC374491_uc001upn.2_RNA|LOC374491_uc001upo.2_RNA					Homo sapiens mRNA; cDNA DKFZp434J0717 (from clone DKFZp434J0717).												0						TGAAACATCTCTACAACTGGA	0.343													3	39					0	0	0	0
CDK8	1024	broad.mit.edu	37	13	26911771	26911771	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr13:26911771G>C	uc001uqr.1	+	2	222	c.196G>C	c.(196-198)GAA>CAA	p.E66Q	CDK8_uc001uqs.1_Missense_Mutation_p.E66Q|CDK8_uc001uqt.1_5'UTR	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	66	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		GGCATGTAGAGAAATAGCAGT	0.289													30	51					0	0	0	0
ALG5	29880	broad.mit.edu	37	13	37524134	37524134	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr13:37524134C>T	uc001uvy.2	-	10	987	c.920G>A	c.(919-921)CGA>CAA	p.R307Q	ALG5_uc010teq.1_Missense_Mutation_p.R277Q|ALG5_uc010ter.1_RNA	NM_013338	NP_037470	Q9Y673	ALG5_HUMAN	dolichyl-phosphate beta-glucosyltransferase	307	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate beta-glucosyltransferase activity|oligosaccharyl transferase activity				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;5.79e-07)|Epithelial(112;1.81e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00785)|BRCA - Breast invasive adenocarcinoma(63;0.0127)|GBM - Glioblastoma multiforme(144;0.0472)		ATATCGAAGTCGTATAAAAAG	0.353													16	33					0	0	0	0
FREM2	341640	broad.mit.edu	37	13	39446956	39446956	+	Silent	SNP	G	T	T	rs147947821		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr13:39446956G>T	uc001uwv.2	+	17	8370	c.8061G>T	c.(8059-8061)GGG>GGT	p.G2687G		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2687	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCCCCGTGGGGGTAGGAGGCT	0.488													40	64					9.8876e-21	1.47677e-20	1	0
HTR2A	3356	broad.mit.edu	37	13	47409480	47409480	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr13:47409480G>A	uc001vbq.2	-	3	1042	c.908C>T	c.(907-909)CCA>CTA	p.P303L	HTR2A_uc001vbr.2_Missense_Mutation_p.P203L|HTR2A_uc010acr.2_Missense_Mutation_p.P303L	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	303	Cytoplasmic (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GTAGGACCCTGGCTCCCTATG	0.517													21	29					0	0	0	0
SLC15A1	6564	broad.mit.edu	37	13	99364806	99364806	+	Silent	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr13:99364806A>G	uc001vno.2	-	10	833	c.756T>C	c.(754-756)AGT>AGC	p.S252S		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	252	Cytoplasmic (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	GAAATGCCTTACTCCGATGCC	0.433													37	92					0	0	0	0
DOCK9	23348	broad.mit.edu	37	13	99452600	99452600	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr13:99452600G>A	uc001vnt.2	-	52	5958	c.5903C>T	c.(5902-5904)TCG>TTG	p.S1968L	DOCK9_uc001vnw.2_Missense_Mutation_p.S1967L|DOCK9_uc001vnq.2_Missense_Mutation_p.S515L|DOCK9_uc001vnr.2_Missense_Mutation_p.S597L|DOCK9_uc010tin.1_Missense_Mutation_p.S586L|DOCK9_uc001vns.2_Missense_Mutation_p.S503L|DOCK9_uc010tio.1_Missense_Mutation_p.S623L|DOCK9_uc010tip.1_Missense_Mutation_p.S664L	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1968	Potential.|DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CACCTCGGCCGAGGAGCACAG	0.612													11	21					0	0	0	0
COL4A1	1282	broad.mit.edu	37	13	110814632	110814632	+	Silent	SNP	G	A	A	rs149068853		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr13:110814632G>A	uc001vqw.3	-	48	4529	c.4407C>T	c.(4405-4407)CAC>CAT	p.H1469H	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1469	Collagen IV NC1.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AAGAGTACCCGTGGTAAAGAA	0.512													7	373					0	0	0	0
COL4A1	1282	broad.mit.edu	37	13	110828798	110828798	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr13:110828798C>T	uc001vqw.3	-	36	3153	c.3031G>A	c.(3031-3033)GGA>AGA	p.G1011R	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1011	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCAACAGATCCTTTTGGTCCC	0.483													23	44					0	0	0	0
Unknown	0	broad.mit.edu	37	14	19856854	19856854	+	RNA	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr14:19856854C>G	uc001vvq.1	-	5		c.676G>C								Homo sapiens cDNA FLJ12852 fis, clone NT2RP2003445.																		CTCATGTCATCTACAGCACTC	0.343													7	40					0	0	0	0
OR4Q3	441669	broad.mit.edu	37	14	20216179	20216179	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr14:20216179T>A	uc010tkt.1	+	1	593	c.593T>A	c.(592-594)GTG>GAG	p.V198E		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTGGTAGAGGTGCTGGTGATA	0.493													25	36					0	0	0	0
METTL3	56339	broad.mit.edu	37	14	21969087	21969087	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr14:21969087C>T	uc001wbc.2	-	5	1176	c.1084G>A	c.(1084-1086)GAT>AAT	p.D362N	METTL3_uc001wbb.2_Missense_Mutation_p.D207N|METTL3_uc010tlw.1_RNA	NM_019852	NP_062826	Q86U44	MTA70_HUMAN	methyltransferase like 3	362					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			pancreas(1)|skin(1)	2	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		GCACTGGAATCACCTCCGACA	0.507													12	8					0	0	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65194605	65194605	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr14:65194605C>T	uc001xho.1	+	2	525	c.256C>T	c.(256-258)CCT>TCT	p.P86S	PLEKHG3_uc001xhn.1_Missense_Mutation_p.P86S|PLEKHG3_uc001xhp.2_Missense_Mutation_p.P86S|PLEKHG3_uc010aqh.1_5'Flank	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	86					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		AGCGGCAGGGCCTGCACACCA	0.637													8	4					0	0	0	0
OR4N4	283694	broad.mit.edu	37	15	22332432	22332432	+	Translation_Start_Site	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr15:22332432C>T	uc001yuc.1	+	3	239	c.-742C>T	c.(-744--740)AACGT>AATGT		LOC727924_uc001ytz.1_Intron|LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		AAGATTCTAACGTGACAGAAC	0.328													4	26					0	0	0	0
Unknown	0	broad.mit.edu	37	15	22473030	22473030	+	RNA	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr15:22473030G>T	uc001yuj.1	-	2		c.241C>A								Homo sapiens IGH mRNA for immunoglobulin heavy chain VHDJ region, partial cds, clone:H6.																		TTGAGGGACGGGTTGTAGTTG	0.567													65	159					6.20203e-27	9.55003e-27	1	0
CYFIP1	23191	broad.mit.edu	37	15	22956494	22956494	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr15:22956494G>C	uc001yus.2	+	16	1835	c.1731G>C	c.(1729-1731)AAG>AAC	p.K577N	CYFIP1_uc001yut.2_Missense_Mutation_p.K577N|CYFIP1_uc010aya.1_Missense_Mutation_p.K605N|CYFIP1_uc001yuu.2_Missense_Mutation_p.K146N	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	577					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GTGGTTCCAAGAAAACCTTGA	0.408													32	15					0	0	0	0
C15orf2	23742	broad.mit.edu	37	15	24923926	24923926	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr15:24923926C>G	uc001ywo.2	+	1	3386	c.2912C>G	c.(2911-2913)GCT>GGT	p.A971G		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	971					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AATGCAAGTGCTTTCCCCAAT	0.483													28	16					0	0	0	0
SNORD115-13	100033450	broad.mit.edu	37	15	25438354	25438354	+	RNA	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr15:25438354C>G	uc001yzf.1	+	3		c.232C>G			SNORD115-13_uc001yzh.2_5'Flank|SNORD115-14_uc001yzj.1_5'Flank					Homo sapiens clone Rt-11 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0						GTGCTGAGCCCCTGGTGCACT	0.597													46	16					0	0	0	0
RYR3	6263	broad.mit.edu	37	15	33954863	33954863	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr15:33954863G>C	uc001zhi.2	+	35	5202	c.5132G>C	c.(5131-5133)CGA>CCA	p.R1711P	RYR3_uc010bar.2_Missense_Mutation_p.R1711P	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1711	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCCCACATCCGAGACCCTGTA	0.562													23	18					0	0	0	0
SLC24A5	283652	broad.mit.edu	37	15	48434437	48434437	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr15:48434437C>T	uc001zwe.2	+	9	1465	c.1392C>T	c.(1390-1392)GAC>GAT	p.D464D	SLC24A5_uc010bel.2_Silent_p.D404D|MYEF2_uc001zwg.3_3'UTR|MYEF2_uc001zwh.3_3'UTR|MYEF2_uc001zwi.3_3'UTR|MYEF2_uc001zwj.3_3'UTR|SLC24A5_uc001zwk.2_Silent_p.D95D	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	464	Extracellular (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		GGAAACTAGACAGAAAGTTGG	0.343													40	20					0	0	0	0
FBN1	2200	broad.mit.edu	37	15	48818391	48818391	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr15:48818391G>A	uc001zwx.1	-	9	1252	c.924C>T	c.(922-924)GTC>GTT	p.V308V		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	308	EGF-like 5; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AGTAACTGCTGACTGTGTTTG	0.403													50	11					0	0	0	0
SGK269	79834	broad.mit.edu	37	15	77474169	77474169	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr15:77474169C>T	uc002bcm.2	-	3	408	c.100G>A	c.(100-102)GAG>AAG	p.E34K	SGK269_uc002bcn.2_Missense_Mutation_p.E34K	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	34					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		GGTGCCTTCTCAGGGTCTGGG	0.468													8	182					0	0	0	0
BNC1	646	broad.mit.edu	37	15	83926817	83926817	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr15:83926817C>T	uc002bjt.1	-	5	2450	c.2362G>A	c.(2362-2364)GAA>AAA	p.E788K	BNC1_uc010uos.1_Missense_Mutation_p.E776K	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	788					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AAATGATCTTCACTACTCTCC	0.458													36	63					0	0	0	0
AKAP13	11214	broad.mit.edu	37	15	86124699	86124699	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr15:86124699G>A	uc002blv.1	+	7	3570	c.3400G>A	c.(3400-3402)GTG>ATG	p.V1134M	AKAP13_uc002blt.1_Missense_Mutation_p.V1134M|AKAP13_uc002blu.1_Missense_Mutation_p.V1134M|AKAP13_uc010bne.1_5'Flank	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	1134					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						AGGTTTGCCAGTGGCTCTACA	0.507													64	19					0	0	0	0
LRRK1	79705	broad.mit.edu	37	15	101567909	101567909	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr15:101567909G>T	uc002bwr.2	+	19	2912	c.2593G>T	c.(2593-2595)GAC>TAC	p.D865Y	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	865					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CAGCCGGGACGACGACGTGCA	0.662													12	7					7.93312e-07	9.75522e-07	1	0
GRIN2A	2903	broad.mit.edu	37	16	10274094	10274094	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr16:10274094G>T	uc002czo.3	-	2	723	c.175C>A	c.(175-177)CAG>AAG	p.Q59K	GRIN2A_uc010uym.1_Missense_Mutation_p.Q59K|GRIN2A_uc002czr.3_Missense_Mutation_p.Q59K|GRIN2A_uc010buk.2_Missense_Mutation_p.Q59K	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	59	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCCGCCGCCTGCTCGGGGCCC	0.657													44	77					1.8453e-21	2.79201e-21	1	0
ARHGAP17	55114	broad.mit.edu	37	16	24980081	24980081	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr16:24980081C>A	uc002dnb.2	-	5	378	c.285G>T	c.(283-285)GAG>GAT	p.E95D	ARHGAP17_uc002dnc.2_Missense_Mutation_p.E95D|ARHGAP17_uc010vcf.1_Intron|ARHGAP17_uc002dnf.2_Missense_Mutation_p.E3D|ARHGAP17_uc002dng.1_Missense_Mutation_p.E95D	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	95	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		CTCCACACGTCTCCAGCATCT	0.507													27	38					2.41591e-17	3.45982e-17	1	0
RABEP2	79874	broad.mit.edu	37	16	28917494	28917494	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr16:28917494G>A	uc002drq.2	-	9	1317	c.1269C>T	c.(1267-1269)TGC>TGT	p.C423C	uc010vct.1_Intron|RABEP2_uc010vdf.1_Silent_p.C352C|RABEP2_uc010byn.2_Silent_p.C391C	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	423	Potential.				endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						CTTGCCGCGTGCAGCACAGCA	0.716													7	10					0	0	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29888756	29888756	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr16:29888756A>T	uc002duq.3	-	11	1985	c.1745T>A	c.(1744-1746)CTG>CAG	p.L582Q	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.L512Q|SEZ6L2_uc002dur.3_Missense_Mutation_p.L512Q|SEZ6L2_uc002dus.3_Missense_Mutation_p.L468Q|SEZ6L2_uc010vec.1_Missense_Mutation_p.L582Q|SEZ6L2_uc010ved.1_Missense_Mutation_p.L538Q	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	582	CUB 3.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CCCGTCGAACAGCGTCAGCAT	0.692													10	26					0	0	0	0
VKORC1	79001	broad.mit.edu	37	16	31105904	31105904	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr16:31105904G>A	uc002eas.2	-	1	373	c.147C>T	c.(145-147)ATC>ATT	p.I49I	PRSS53_uc002ear.2_5'UTR|VKORC1_uc002eat.2_Silent_p.I49I|VKORC1_uc002eau.2_Silent_p.I49I	NM_024006	NP_076869	Q9BQB6	VKOR1_HUMAN	vitamin K epoxide reductase complex, subunit 1	49	Cytoplasmic (Potential).				peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane	vitamin-K-epoxide reductase (warfarin-sensitive) activity				0					Acenocoumarol(DB01418)|Dicumarol(DB00266)|Menadione(DB00170)|Phenindione(DB00498)|Phenprocoumon(DB00946)|Warfarin(DB00682)	GCGAACAGCTGATGGCGGTGC	0.682													12	11					0	0	0	0
Unknown	0	broad.mit.edu	37	16	32190817	32190817	+	RNA	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr16:32190817G>T	uc010vfv.1	-	7		c.1007C>A								Homo sapiens cDNA FLJ60890 complete cds, moderately similar to HECT domain and RCC1-like domain-containing protein 2.																		TGGCAAGCTCGTTGTCTTGTG	0.498													7	31					3.09899e-07	3.8654e-07	1	0
CMTM1	113540	broad.mit.edu	37	16	66603837	66603837	+	Splice_Site	SNP	A	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr16:66603837A>T	uc002epi.3	+	2	205	c.82_splice	c.e2-2	p.S28_splice	CMTM1_uc002epb.3_Splice_Site|CMTM1_uc002epc.3_Splice_Site|CMTM1_uc002epd.3_Intron|CMTM1_uc002epe.3_Intron|CMTM1_uc002epf.3_Intron|CMTM1_uc002epg.3_Intron|CMTM1_uc002eph.3_Splice_Site_p.S28_splice|CMTM1_uc002epl.3_Intron|CMTM1_uc002epj.3_Intron|CMTM1_uc002epk.3_Intron|CMTM1_uc002epa.3_Intron|CMTM1_uc002epn.3_Splice_Site_p.S145_splice|CMTM1_uc002epo.3_Splice_Site|CMTM1_uc002epp.3_Splice_Site|CMTM1_uc002epq.3_Splice_Site|CMTM1_uc010cds.2_Splice_Site|CMTM1_uc002epr.3_Splice_Site_p.S145_splice|CMTM1_uc002epm.3_Splice_Site|CMTM1_uc002eps.2_5'Flank	NM_181269	NP_851786	Q8IZ96	CKLF1_HUMAN	chemokine-like factor superfamily 1 isoform 1						chemotaxis	extracellular space|integral to membrane	cytokine activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)		CTTTTATTGCAGAGTCTTATC	0.323													31	57					0	0	0	0
FUK	197258	broad.mit.edu	37	16	70499039	70499039	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr16:70499039C>T	uc002eyy.2	+	4	303	c.245C>T	c.(244-246)TCC>TTC	p.S82F	FUK_uc010vmb.1_Intron|FUK_uc010cft.2_Missense_Mutation_p.S114F|FUK_uc002eyz.2_Intron	NM_145059	NP_659496	Q8N0W3	FUK_HUMAN	fucokinase	82						cytoplasm	ATP binding|fucokinase activity			ovary(1)	1		Ovarian(137;0.0694)				GTGGTCACATCCGATGTCCTG	0.572													11	14					0	0	0	0
PMFBP1	83449	broad.mit.edu	37	16	72188112	72188112	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr16:72188112C>T	uc002fcc.3	-	4	584	c.412G>A	c.(412-414)GAG>AAG	p.E138K	PMFBP1_uc002fcd.2_Missense_Mutation_p.E138K|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_5'UTR	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	138										ovary(2)	2		Ovarian(137;0.179)				GTCTATACCTCATCTTCTTTC	0.463													42	68					0	0	0	0
IRF8	3394	broad.mit.edu	37	16	85946795	85946795	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr16:85946795G>T	uc002fjh.2	+	5	563	c.506G>T	c.(505-507)TGT>TTT	p.C169F	IRF8_uc010chp.2_Intron	NM_002163	NP_002154	Q02556	IRF8_HUMAN	interferon regulatory factor 8	169					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|ovary(1)	3		Prostate(104;0.0771)				CCGGAGGCCTGTCGGAGTCAG	0.617													48	88					6.17242e-35	9.89862e-35	1	0
TP53	7157	broad.mit.edu	37	17	7577557	7577557	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr17:7577557A>T	uc002gim.2	-	7	918	c.724T>A	c.(724-726)TGC>AGC	p.C242S	TP53_uc002gig.1_Missense_Mutation_p.C242S|TP53_uc002gih.2_Missense_Mutation_p.C242S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C110S|TP53_uc010cng.1_Missense_Mutation_p.C110S|TP53_uc002gii.1_Missense_Mutation_p.C110S|TP53_uc010cnh.1_Missense_Mutation_p.C242S|TP53_uc010cni.1_Missense_Mutation_p.C242S|TP53_uc002gij.2_Missense_Mutation_p.C242S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C149S|TP53_uc002gio.2_Missense_Mutation_p.C110S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	242	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).	Zinc.	C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C242F(63)|p.C242Y(37)|p.C242S(25)|p.C242fs*5(16)|p.C242R(11)|p.C242W(7)|p.0?(7)|p.N239_C242delNSSC(3)|p.C242*(3)|p.S241del(2)|p.C242C(2)|p.C242G(2)|p.C242fs*20(1)|p.C242fs*23(1)|p.Y236_M243delYMCNSSCM(1)|p.C242_M246>L(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_C242insX(1)|p.C238fs*21(1)|p.C242fs*98(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241_G245delSCMGG(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGCCCATGCAGGAACTGTTA	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			67	22					0	0	0	0
MYH4	4622	broad.mit.edu	37	17	10351339	10351339	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr17:10351339G>A	uc002gmn.2	-	34	4872	c.4761C>T	c.(4759-4761)CTC>CTT	p.L1587L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1587	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TTAGCTGATCGAGTTCTTCAT	0.418													6	155					0	0	0	0
COX10	1352	broad.mit.edu	37	17	13977709	13977709	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr17:13977709A>G	uc002gof.3	+	2	317	c.113A>G	c.(112-114)CAT>CGT	p.H38R	COX10_uc010vvs.1_5'UTR|COX10_uc010vvt.1_5'UTR	NM_001303	NP_001294	Q12887	COX10_HUMAN	heme A:farnesyltransferase precursor	38					heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity				0		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		AAGTTCTTACATCTTCTCAGG	0.403													63	95					0	0	0	0
LYZL6	57151	broad.mit.edu	37	17	34266465	34266465	+	Translation_Start_Site	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr17:34266465G>T	uc002hkj.1	-	1	46	c.-104C>A	c.(-106--102)ACCTG>ACATG		LYZL6_uc002hkk.1_Intron	NM_020426	NP_065159	O75951	LYZL6_HUMAN	lysozyme-like 6 precursor						cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGGGCAGCCAGGTTTCCTTAC	0.418													8	23					0.00307968	0.00360851	1	0
THRA	7067	broad.mit.edu	37	17	38249328	38249328	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr17:38249328C>A	uc002htw.2	+	10	1649	c.1166C>A	c.(1165-1167)CCG>CAG	p.P389Q	THRA_uc002htx.2_Intron|NR1D1_uc002htz.1_3'UTR|NR1D1_uc010cwq.1_RNA	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	389					negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	GAAGGCCGGCCGGGCGGGTCA	0.552													31	57					4.4194e-11	5.80359e-11	1	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39261693	39261693	+	Missense_Mutation	SNP	A	T	T	rs113059833	by1000genomes	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr17:39261693A>T	uc010wfp.1	+	1	53	c.53A>T	c.(52-54)GAC>GTC	p.D18V		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	18						keratin filament					0						TGCGGCCAAGACCTCTGTCAG	0.627													5	52					0	0	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274150	39274150	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr17:39274150T>A	uc002hvz.2	-	1	457	c.418A>T	c.(418-420)AGC>TGC	p.S140C		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	140	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ctggagatgctgcagctgggg	0.129													4	52					0	0	0	0
RPS6KB1	6198	broad.mit.edu	37	17	58024140	58024140	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr17:58024140G>C	uc002ixy.2	+	15	1672	c.1569G>C	c.(1567-1569)ATG>ATC	p.M523I	RPS6KB1_uc010ddj.1_Intron|RPS6KB1_uc010wom.1_Missense_Mutation_p.M470I|RPS6KB1_uc010won.1_Missense_Mutation_p.M500I|RPS6KB1_uc010woo.1_Missense_Mutation_p.M458I|RPS6KB1_uc002ixz.2_RNA	NM_003161	NP_003152	P23443	KS6B1_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide	523	Autoinhibitory domain.				apoptosis|G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|negative regulation of apoptosis|phosphatidylinositol-mediated signaling|positive regulation of mitotic cell cycle|positive regulation of translational initiation|TOR signaling cascade	cell junction|cytoplasm|cytosol|mitochondrial outer membrane|nucleus|nucleus|synapse|synaptosome	ATP binding|protein binding|protein kinase activity			large_intestine(1)	1	all_cancers(5;1.63e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.57e-12)|all cancers(12;6.41e-11)			ACCTGCGTATGAATCTATGAC	0.463													31	45					0	0	0	0
RECQL5	9400	broad.mit.edu	37	17	73657115	73657115	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr17:73657115C>G	uc010dgl.2	-	6	1062	c.906G>C	c.(904-906)CAG>CAC	p.Q302H	RECQL5_uc010dgk.2_Missense_Mutation_p.Q275H|RECQL5_uc002jpb.1_Missense_Mutation_p.Q302H|RECQL5_uc002joz.3_Missense_Mutation_p.Q302H|RECQL5_uc002jpa.3_Missense_Mutation_p.Q302H	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	302	Helicase C-terminal.				DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			TCCAGTCGTTCTGCACCAGCG	0.453								Other_identified_genes_with_known_or_suspected_DNA_repair_function					14	110					0	0	0	0
GAA	2548	broad.mit.edu	37	17	78081647	78081647	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr17:78081647G>A	uc002jxo.2	+	6	1089	c.907G>A	c.(907-909)GAC>AAC	p.D303N	GAA_uc002jxp.2_Missense_Mutation_p.D303N|GAA_uc002jxq.2_Missense_Mutation_p.D303N	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	303					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GGCGCTGGAGGACGGCGGGTC	0.677													3	25					0	0	0	0
LAMA1	284217	broad.mit.edu	37	18	7079974	7079974	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr18:7079974C>G	uc002knm.2	-	3	439	c.345G>C	c.(343-345)CAG>CAC	p.Q115H	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	115	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTCACCTACCTGTCTTAAGT	0.468													9	59					0	0	0	0
C18orf1	753	broad.mit.edu	37	18	13621229	13621229	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr18:13621229C>T	uc002ksa.2	+	5	963	c.295C>T	c.(295-297)CGC>TGC	p.R99C	C18orf1_uc002ksb.2_Missense_Mutation_p.R99C|C18orf1_uc002kse.2_Missense_Mutation_p.R62C|C18orf1_uc002ksf.2_Missense_Mutation_p.R62C|C18orf1_uc002ksg.1_Missense_Mutation_p.R22C|C18orf1_uc002ksh.1_Missense_Mutation_p.R41C|C18orf1_uc002ksi.1_Missense_Mutation_p.R41C	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	99	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		CTTCATCAACCGCCCGAACCA	0.637													102	29					0	0	0	0
HRH4	59340	broad.mit.edu	37	18	22056718	22056718	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr18:22056718A>T	uc002kvi.2	+	3	465	c.365A>T	c.(364-366)TAT>TTT	p.Y122F	HRH4_uc010xbd.1_Missense_Mutation_p.L67F|HRH4_uc010dlx.2_Intron	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	122	Cytoplasmic (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	TAGGTGTCTTATAGAACTCAA	0.378													7	42					0	0	0	0
ZNF521	25925	broad.mit.edu	37	18	22804737	22804737	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr18:22804737C>A	uc002kvk.2	-	4	3392	c.3145G>T	c.(3145-3147)GGG>TGG	p.G1049W	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.G1049W|ZNF521_uc002kvl.2_Missense_Mutation_p.G829W	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1049					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					ACTGCAGACCCATTCCCTGTC	0.522			T	PAX5	ALL								19	20					8.00594e-06	9.70755e-06	1	0
CD226	10666	broad.mit.edu	37	18	67614187	67614187	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr18:67614187G>A	uc010dqo.2	-	2	612	c.165C>T	c.(163-165)ACC>ACT	p.T55T	CD226_uc002lkm.3_Silent_p.T55T	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	55	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				AATCCTGCTGGGTCCCGATCT	0.463													21	15					0	0	0	0
SAFB2	9667	broad.mit.edu	37	19	5598876	5598876	+	Silent	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:5598876C>G	uc002mcd.2	-	13	1922	c.1710G>C	c.(1708-1710)CGG>CGC	p.R570R		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		TCACGACCGTCCGCTCCATTC	0.507													26	48					0	0	0	0
DUS3L	56931	broad.mit.edu	37	19	5786796	5786796	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:5786796C>T	uc002mdc.2	-	9	1547	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	PRR22_uc002mdb.1_5'Flank|PRR22_uc010xiv.1_5'Flank|DUS3L_uc002mdd.2_Missense_Mutation_p.E242K|DUS3L_uc010duk.2_Missense_Mutation_p.E149K	NM_020175	NP_064560	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like isoform 1	484					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding				0						TGCACGCACTCCTCGATGTAC	0.612													19	33					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9000496	9000496	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:9000496C>A	uc002mkp.2	-	54	40692	c.40488G>T	c.(40486-40488)ATG>ATT	p.M13496I	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.M313I|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13498	SEA 10.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGGGTGATGCATGTTCTCCT	0.478													33	66					9.65021e-13	1.30166e-12	1	0
ZNF560	147741	broad.mit.edu	37	19	9577562	9577562	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:9577562G>A	uc002mlp.1	-	10	2271	c.2061C>T	c.(2059-2061)AAC>AAT	p.N687N	ZNF560_uc010dwr.1_Silent_p.N581N	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	687					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						TTCCACATGCGTTACATTCAG	0.373													69	111					0	0	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10221511	10221511	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:10221511C>T	uc002mna.2	+	11	1170	c.1170C>T	c.(1168-1170)TTC>TTT	p.F390F	PPAN-P2RY11_uc010xla.1_Silent_p.F390F|P2RY11_uc002mnc.2_5'Flank|PPAN_uc002mmz.1_Silent_p.F390F|PPAN_uc002mnb.1_Silent_p.F337F	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	390					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			TCGAGTATTTCTGCCAGGCGG	0.607													67	140					0	0	0	0
KRI1	65095	broad.mit.edu	37	19	10665770	10665770	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:10665770G>C	uc002moy.1	-	18	1801	c.1792C>G	c.(1792-1794)CGA>GGA	p.R598G	KRI1_uc002mow.1_Missense_Mutation_p.R217G|KRI1_uc002mox.1_Missense_Mutation_p.R594G	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	598										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			tactcttctCGGCAGAGTGAC	0.303													25	39					0	0	0	0
ZNF878	729747	broad.mit.edu	37	19	12155285	12155285	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:12155285A>G	uc002mta.1	-	5	1072	c.1072T>C	c.(1072-1074)TAT>CAT	p.Y358H		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	311	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TTACACTCATAGGGTTTCTCT	0.403													33	74					0	0	0	0
CYP4F22	126410	broad.mit.edu	37	19	15651373	15651373	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:15651373C>T	uc002nbh.3	+	8	951	c.784C>T	c.(784-786)CGG>TGG	p.R262W		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	262						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						GGCGGATGGGCGGAGGTTCCG	0.607													29	90					0	0	0	0
UNC13A	23025	broad.mit.edu	37	19	17728564	17728564	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:17728564G>A	uc002nhd.2	-	40	4769	c.4769C>T	c.(4768-4770)ACG>ATG	p.T1590M		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1502	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						GGTGGCCTGCGTGTAGAGCGA	0.607													50	72					0	0	0	0
DYRK1B	9149	broad.mit.edu	37	19	40321360	40321360	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:40321360C>T	uc002omj.2	-	3	407	c.127G>A	c.(127-129)GCC>ACC	p.A43T	DYRK1B_uc002omi.2_Missense_Mutation_p.A43T|DYRK1B_uc002omk.2_Missense_Mutation_p.A43T|DYRK1B_uc002oml.2_Missense_Mutation_p.A43T	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	43					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			CGCAGCGGGGCTGAGGTTGCA	0.642													30	42					0	0	0	0
ZNF226	7769	broad.mit.edu	37	19	44680226	44680226	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:44680226C>T	uc002oyp.2	+	6	955	c.811C>T	c.(811-813)CAG>TAG	p.Q271*	ZNF226_uc002oyq.2_Nonsense_Mutation_p.Q154*|ZNF226_uc002oyr.2_Nonsense_Mutation_p.Q154*|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Nonsense_Mutation_p.Q271*|ZNF226_uc002oyt.2_Nonsense_Mutation_p.Q271*	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	271	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				TGATCTTCATCAGCAGTTACA	0.423													23	42					0	0	0	0
ZNF233	353355	broad.mit.edu	37	19	44778658	44778658	+	Silent	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:44778658G>T	uc002oyz.1	+	5	1972	c.1845G>T	c.(1843-1845)ACG>ACT	p.T615T	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Silent_p.T430T	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	615					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				GGATCCACACGGGAGAGAAAC	0.438													38	56					1.06647e-15	1.50256e-15	1	0
ZFP112	7771	broad.mit.edu	37	19	44832694	44832694	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:44832694C>G	uc010ejj.2	-	5	1747	c.1634G>C	c.(1633-1635)AGA>ACA	p.R545T	ZFP112_uc002ozc.3_Missense_Mutation_p.R539T|ZFP112_uc010xwy.1_Missense_Mutation_p.R562T|ZFP112_uc010xwz.1_Missense_Mutation_p.R544T	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	545	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TGTGTGGACTCTCTGATGAAC	0.423													61	101					0	0	0	0
FCAR	2204	broad.mit.edu	37	19	55396680	55396680	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:55396680C>A	uc002qhr.1	+	3	301	c.104C>A	c.(103-105)TCG>TAG	p.S35*	FCAR_uc002qhq.2_Nonsense_Mutation_p.S35*|FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Nonsense_Mutation_p.S8*|FCAR_uc010esi.1_Nonsense_Mutation_p.S8*|FCAR_uc002qhu.1_Nonsense_Mutation_p.S35*|FCAR_uc002qhv.1_Nonsense_Mutation_p.S35*|FCAR_uc002qhw.1_Nonsense_Mutation_p.S23*|FCAR_uc002qhx.1_Nonsense_Mutation_p.S23*|FCAR_uc002qhy.1_Nonsense_Mutation_p.S23*|FCAR_uc002qhz.1_Nonsense_Mutation_p.S23*|FCAR_uc002qia.1_Intron	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	35	Extracellular (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		TCTGCCAAATCGAGTCCTGTG	0.498													22	34					3.62473e-10	4.68924e-10	1	0
ZIM3	114026	broad.mit.edu	37	19	57646307	57646307	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:57646307C>T	uc002qnz.1	-	5	1784	c.1398G>A	c.(1396-1398)CAG>CAA	p.Q466Q		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	466	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAATTCTTTTCTGGTGCCTAA	0.428													49	70					0	0	0	0
ZNF776	284309	broad.mit.edu	37	19	58265188	58265188	+	Silent	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:58265188C>A	uc002qpx.2	+	3	913	c.690C>A	c.(688-690)CTC>CTA	p.L230L	ZNF587_uc002qqb.2_Intron|ZNF776_uc002qqa.2_Silent_p.L230L	NM_173632	NP_775903	Q68DI1	ZN776_HUMAN	zinc finger protein 776	230	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		AGAGACTTCTCCCTAGAGAAG	0.418													38	69					1.04594e-18	1.52936e-18	1	0
KIDINS220	57498	broad.mit.edu	37	2	8936972	8936972	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:8936972T>C	uc002qzc.2	-	11	1209	c.1027A>G	c.(1027-1029)ACC>GCC	p.T343A	KIDINS220_uc010yiv.1_Missense_Mutation_p.T109A|KIDINS220_uc002qzd.2_Missense_Mutation_p.T301A|KIDINS220_uc010yiw.1_Missense_Mutation_p.T344A	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	343	Cytoplasmic (Potential).|ANK 11.				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CTCATCTTGGTAGCCTTTATA	0.418													64	121					0	0	0	0
APOB	338	broad.mit.edu	37	2	21228818	21228818	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:21228818G>T	uc002red.2	-	26	11050	c.10922C>A	c.(10921-10923)TCT>TAT	p.S3641Y		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3641					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GAAAGACCCAGAATGAATCCG	0.463													14	26					1.5842e-08	1.99747e-08	1	0
BIRC6	57448	broad.mit.edu	37	2	32728276	32728276	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:32728276G>A	uc010ezu.2	+	49	9606	c.9472G>A	c.(9472-9474)GAA>AAA	p.E3158K		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3158					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TGACAATGCTGAAGGGATTCA	0.338													7	17					0	0	0	0
LRRTM1	347730	broad.mit.edu	37	2	80529897	80529897	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:80529897C>A	uc002sok.1	-	2	1318	c.1048G>T	c.(1048-1050)GGC>TGC	p.G350C	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	350	LRRCT.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						ACGTCCTCGCCCTGTGCGTAC	0.672										HNSCC(69;0.2)			14	20					1.5842e-08	1.99747e-08	1	0
Unknown	0	broad.mit.edu	37	2	90139424	90139424	+	RNA	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:90139424C>A	uc010fhm.2	+	18		c.2217C>A								Parts of antibodies, mostly variable regions.																		CAGAGAAAGCCCCTAAGTCCC	0.522													103	218					3.52173e-36	5.70028e-36	1	0
MITD1	129531	broad.mit.edu	37	2	99797327	99797327	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:99797327C>T	uc002szs.1	-	1	166	c.118G>A	c.(118-120)GAG>AAG	p.E40K	MRPL30_uc002szl.1_Intron|MRPL30_uc002szr.2_Intron|MRPL30_uc002szt.1_5'Flank|MRPL30_uc002szu.2_5'Flank|MRPL30_uc002szv.2_5'Flank	NM_138798	NP_620153	Q8WV92	MITD1_HUMAN	MIT, microtubule interacting and transport,	40	MIT.				protein transport	late endosome membrane				large_intestine(1)|ovary(1)	2						TCAATCCCCTCTTGGTAACAC	0.582													65	104					0	0	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143913079	143913079	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:143913079C>G	uc002tvm.3	+	2	171	c.20C>G	c.(19-21)TCT>TGT	p.S7C	ARHGAP15_uc010zbl.1_Missense_Mutation_p.S7C	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	7					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		TCTACAAATTCTGATACTTCC	0.373													11	18					0	0	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143913203	143913203	+	Silent	SNP	T	C	C	rs146989390	by1000genomes	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:143913203T>C	uc002tvm.3	+	2	295	c.144T>C	c.(142-144)GAT>GAC	p.D48D	ARHGAP15_uc010zbl.1_Silent_p.D48D	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	48					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		TCCTCACCGATGTCGGGAAGG	0.423													26	23					0	0	0	0
KCNJ3	3760	broad.mit.edu	37	2	155711512	155711512	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:155711512A>G	uc002tyv.1	+	3	1388	c.1193A>G	c.(1192-1194)AAA>AGA	p.K398R	KCNJ3_uc010zce.1_3'UTR	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	398	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	ATTACTACAAAACTACCATCT	0.388													64	98					0	0	0	0
SCN3A	6328	broad.mit.edu	37	2	165986510	165986510	+	Silent	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:165986510G>T	uc002ucx.2	-	17	3354	c.2862C>A	c.(2860-2862)GTC>GTA	p.V954V	SCN3A_uc002ucy.2_Silent_p.V905V|SCN3A_uc002ucz.2_Silent_p.V905V|SCN3A_uc002uda.1_Silent_p.V774V|SCN3A_uc002udb.1_Silent_p.V774V	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	954						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTTGGCCAGCGACCTCCATAC	0.468													188	143					3.0798e-103	5.10367e-103	1	0
NFE2L2	4780	broad.mit.edu	37	2	178098973	178098973	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:178098973C>G	uc002ulh.3	-	2	627	c.72G>C	c.(70-72)TGG>TGC	p.W24C	NFE2L2_uc002ulg.3_Missense_Mutation_p.W8C|NFE2L2_uc010zfa.1_Missense_Mutation_p.W8C|NFE2L2_uc002uli.3_Missense_Mutation_p.W8C|NFE2L2_uc010fra.2_Missense_Mutation_p.W8C|NFE2L2_uc010frb.2_Missense_Mutation_p.W8C	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	24					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TATCTTGCCTCCAAAGTATGT	0.348			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			19	20					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179465721	179465721	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:179465721C>A	uc010zfg.1	-	237	48430	c.48206G>T	c.(48205-48207)CGT>CTT	p.R16069L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R9764L|TTN_uc010zfi.1_Missense_Mutation_p.R9697L|TTN_uc010zfj.1_Missense_Mutation_p.R9572L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16996							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCACATCACGCTTATTGCA	0.488													138	102					2.82259e-58	4.61156e-58	1	0
TTN	7273	broad.mit.edu	37	2	179596593	179596593	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:179596593C>G	uc010zfg.1	-	55	13501	c.13277G>C	c.(13276-13278)TGG>TCG	p.W4426S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.W1087S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5353							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTTTGAACCAAGTGATCTC	0.428													37	139					0	0	0	0
Unknown	0	broad.mit.edu	37	2	190788606	190788606	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:190788606C>T	uc002uro.2	+	1	688	c.545C>T	c.(544-546)GCC>GTC	p.A182V						SubName: Full=cDNA FLJ54127, highly similar to Heterogeneous nuclear ribonucleoproteins C;																		GACCTTCAGGCCATTAAGAGG	0.433													7	324					0	0	0	0
CCDC150	284992	broad.mit.edu	37	2	197538986	197538986	+	Missense_Mutation	SNP	A	G	G	rs36060491		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:197538986A>G	uc002utp.1	+	10	1186	c.1051A>G	c.(1051-1053)AAA>GAA	p.K351E	CCDC150_uc010zgq.1_RNA|CCDC150_uc010zgr.1_RNA|CCDC150_uc010zgs.1_Missense_Mutation_p.K19E	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	351											0						CCAATTGACTAAAAAGTGTTC	0.338													7	9					0	0	0	0
AOX1	316	broad.mit.edu	37	2	201468754	201468754	+	Silent	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:201468754C>G	uc002uvx.2	+	8	704	c.603C>G	c.(601-603)CTC>CTG	p.L201L		NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	201					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GTCCAAAACTCTTCGCAGAAG	0.303													32	30					0	0	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170044	207170044	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:207170044G>C	uc002vbp.2	+	5	1042	c.792G>C	c.(790-792)ATG>ATC	p.M264I		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	264							nucleic acid binding|zinc ion binding			ovary(3)	3						CTTTACGCATGAATTCAGATA	0.388													30	25					0	0	0	0
C2orf67	151050	broad.mit.edu	37	2	210893657	210893657	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:210893657A>C	uc002vds.2	-	11	2516	c.2308T>G	c.(2308-2310)TAT>GAT	p.Y770D	C2orf67_uc002vdt.2_Missense_Mutation_p.Y728D	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	770										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		TCTATGTCATAAGAGCTCTCA	0.368													45	65					0	0	0	0
CPS1	1373	broad.mit.edu	37	2	211473158	211473158	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:211473158G>A	uc002vee.3	+	19	2398	c.2266G>A	c.(2266-2268)GGG>AGG	p.G756R	CPS1_uc010fur.2_Missense_Mutation_p.G762R|CPS1_uc010fus.2_Missense_Mutation_p.G305R	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	756					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CGTCGTATCCGGGAAGACATC	0.433													76	85					0	0	0	0
TNS1	7145	broad.mit.edu	37	2	218751275	218751275	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:218751275T>A	uc002vgt.2	-	11	984	c.586A>T	c.(586-588)AAC>TAC	p.N196Y	TNS1_uc002vgr.2_Missense_Mutation_p.N196Y|TNS1_uc002vgs.2_Missense_Mutation_p.N196Y|TNS1_uc010zjv.1_Missense_Mutation_p.N196Y|TNS1_uc010fvj.1_Missense_Mutation_p.N264Y|TNS1_uc010fvk.1_Missense_Mutation_p.N321Y|TNS1_uc002vgu.3_Missense_Mutation_p.N227Y|TNS1_uc010fvi.1_5'Flank	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	196	C2 tensin-type.					cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GACTCAAAGTTGGGGATGCCG	0.522											OREG0015188	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	5					0	0	0	0
HAO1	54363	broad.mit.edu	37	20	7895010	7895010	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr20:7895010C>T	uc002wmw.1	-	3	370	c.346G>A	c.(346-348)GAA>AAA	p.E116K	HAO1_uc010gbu.2_Missense_Mutation_p.E116K	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	116	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						GCCACTTCTTCAATTGAGGAG	0.532													14	36					0	0	0	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	A	A	rs7266938	by1000genomes	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr20:29625877G>A	uc010ztl.1	+	2	63	c.31G>A	c.(31-33)GCC>ACC	p.A11T	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GTACAGAATCGCCCTGAAATC	0.353													4	44					0	0	0	0
FRG1B	284802	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr20:29628263A>G	uc010ztl.1	+	3	207	c.175A>G	c.(175-177)ATT>GTT	p.I59V	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Missense_Mutation_p.I11V					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						TAGCTGCTTTATTAGATGCAA	0.363													3	56					0	0	0	0
KRTAP27-1	643812	broad.mit.edu	37	21	31709388	31709388	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr21:31709388C>A	uc002ynx.1	-	1	625	c.599G>T	c.(598-600)GGT>GTT	p.G200V		NM_001077711	NP_001071179	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	200						intermediate filament				ovary(2)	2						TTGAGAACCACCAGTAACACA	0.408													14	29					0.000219431	0.000260622	1	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253706	32253706	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr21:32253706G>T	uc002yov.2	-	1	169	c.138C>A	c.(136-138)TTC>TTA	p.F46L		NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	46						keratin filament	structural molecule activity			pancreas(1)	1						AGCCAGTCTGGAAGGAACTGG	0.582													24	39					6.21321e-17	8.8253e-17	1	0
TIAM1	7074	broad.mit.edu	37	21	32554912	32554912	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr21:32554912C>T	uc002yow.1	-	16	3185	c.2713G>A	c.(2713-2715)GCC>ACC	p.A905T	TIAM1_uc011adk.1_Missense_Mutation_p.A905T|TIAM1_uc011adl.1_Missense_Mutation_p.A845T	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	905	PDZ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GAGTTCAGGGCGTCAGCAGCA	0.498													5	63					0	0	0	0
HSF2BP	11077	broad.mit.edu	37	21	45076541	45076541	+	Silent	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr21:45076541T>A	uc002zdi.2	-	3	446	c.114A>T	c.(112-114)ATA>ATT	p.I38I	RRP1B_uc002zdk.2_5'Flank|HSF2BP_uc011aey.1_Intron	NM_007031	NP_008962	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding	38					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.18)		AGAAGTCCCGTATTTGCATCA	0.393													39	51					0	0	0	0
COL6A2	1292	broad.mit.edu	37	21	47552400	47552400	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr21:47552400C>A	uc002zia.1	+	28	3076	c.2994C>A	c.(2992-2994)CAC>CAA	p.H998Q	COL6A2_uc002zib.1_Missense_Mutation_p.H404Q|COL6A2_uc002zic.1_Missense_Mutation_p.T73K|COL6A2_uc010gqe.1_RNA	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	998	Nonhelical region.|VWFA 3.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CCGTGTTCCACGAGAAGGACT	0.572													7	18					8.12818e-05	9.75382e-05	1	0
LOC96610	96610	broad.mit.edu	37	22	23241819	23241819	+	RNA	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr22:23241819C>A	uc011aim.1	+	366		c.15435C>A			uc002zws.2_Intron					Parts of antibodies, mostly variable regions.												0						GCGGAGGGACCAAGCTGACCG	0.542													39	45					6.1244e-12	8.10377e-12	1	0
MYO18B	84700	broad.mit.edu	37	22	26242186	26242187	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr22:26242186_26242187CC>AA	uc003abz.1	+	19	3738_3739	c.3488_3489CC>AA	c.(3487-3489)ACC>AAA	p.T1163K	MYO18B_uc003aca.1_Missense_Mutation_p.T1044K|MYO18B_uc010guy.1_Missense_Mutation_p.T1045K|MYO18B_uc010guz.1_Missense_Mutation_p.T1044K|MYO18B_uc011aka.1_Missense_Mutation_p.T317K|MYO18B_uc011akb.1_Missense_Mutation_p.T676K	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1163	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GTGAGGAGGACCTTTGCCAGCA	0.668													27	36					0	0	0	0
DOCK3	1795	broad.mit.edu	37	3	51400017	51400017	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr3:51400017G>A	uc011bds.1	+	49	5228	c.5205G>A	c.(5203-5205)TCG>TCA	p.S1735S		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1735	Ser-rich.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TTCTGTCCTCGTCCCAGGCAA	0.557													32	18					0	0	0	0
PDZRN3	23024	broad.mit.edu	37	3	73432909	73432909	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr3:73432909C>A	uc003dpl.1	-	10	2904	c.2808G>T	c.(2806-2808)AGG>AGT	p.R936S	PDZRN3_uc011bgh.1_Missense_Mutation_p.R593S|PDZRN3_uc010hoe.1_Missense_Mutation_p.R634S|PDZRN3_uc011bgf.1_Missense_Mutation_p.R653S|PDZRN3_uc011bgg.1_Missense_Mutation_p.R656S	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	936							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CCCGCACGGGCCTCTTGGTGA	0.667													19	13					3.99206e-14	5.44798e-14	1	0
OR5H1	26341	broad.mit.edu	37	3	97852283	97852283	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr3:97852283G>T	uc011bgt.1	+	1	742	c.742G>T	c.(742-744)GTC>TTC	p.V248F		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						TCTCTTCTCTGTCTCTTTATA	0.413													45	160					3.7052e-28	5.7563e-28	1	0
MORC1	27136	broad.mit.edu	37	3	108778707	108778707	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr3:108778707T>G	uc003dxl.2	-	12	1064	c.977A>C	c.(976-978)CAG>CCG	p.Q326P	MORC1_uc011bhn.1_Missense_Mutation_p.Q326P	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	326	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CAAAGCTCTCTGTAATACATC	0.358													7	51					0	0	0	0
PLXNA1	5361	broad.mit.edu	37	3	126736700	126736700	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr3:126736700G>A	uc003ejg.2	+	18	3560	c.3556G>A	c.(3556-3558)GAG>AAG	p.E1186K		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1209	Extracellular (Potential).|IPT/TIG 4.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		ACTGCTGTGCGAGGCGCCCAA	0.662													22	71					0	0	0	0
ATP2C1	27032	broad.mit.edu	37	3	130698095	130698095	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr3:130698095C>T	uc003enl.2	+	19	1795	c.1573C>T	c.(1573-1575)CTT>TTT	p.L525F	ATP2C1_uc011blg.1_Missense_Mutation_p.L559F|ATP2C1_uc011blh.1_Missense_Mutation_p.L520F|ATP2C1_uc011bli.1_Missense_Mutation_p.L559F|ATP2C1_uc003enk.2_Missense_Mutation_p.L509F|ATP2C1_uc003enm.2_Missense_Mutation_p.L525F|ATP2C1_uc003enn.2_Missense_Mutation_p.L509F|ATP2C1_uc003eno.2_Missense_Mutation_p.L525F|ATP2C1_uc003enp.2_Missense_Mutation_p.L525F|ATP2C1_uc003enq.2_Missense_Mutation_p.L525F|ATP2C1_uc003enr.2_Missense_Mutation_p.L525F|ATP2C1_uc003ens.2_Missense_Mutation_p.L525F|ATP2C1_uc003ent.2_Missense_Mutation_p.L525F|ATP2C1_uc003enu.2_Missense_Mutation_p.L203F	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	525	Cytoplasmic (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	TTCCTAAGTTCTTGCTTTGGC	0.373									Hailey-Hailey_disease				8	164					0	0	0	0
PLCH1	23007	broad.mit.edu	37	3	155203145	155203145	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr3:155203145C>T	uc011bok.1	-	22	3275	c.2998G>A	c.(2998-3000)GCA>ACA	p.A1000T	PLCH1_uc011boj.1_Missense_Mutation_p.V1000I|PLCH1_uc011bol.1_Missense_Mutation_p.A962T	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1000					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			AGCATCTTACCTAGAGAGTTT	0.423													13	50					0	0	0	0
RSRC1	51319	broad.mit.edu	37	3	157920993	157920993	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr3:157920993G>C	uc003fbt.2	+	4	564	c.453G>C	c.(451-453)AAG>AAC	p.K151N	RSRC1_uc011bou.1_Intron|RSRC1_uc003fbu.1_Missense_Mutation_p.K151N|RSRC1_uc003fbv.2_Intron	NM_016625	NP_057709	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	151				EK -> GE (in Ref. 3; AAF64267).	nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding				0			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			aaaaggagaaggataaaggga	0.368													9	25					0	0	0	0
SLC2A2	6514	broad.mit.edu	37	3	170716928	170716928	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr3:170716928G>T	uc003fhe.1	-	9	1405	c.1096C>A	c.(1096-1098)CGT>AGT	p.R366S	SLC2A2_uc003fhf.1_Missense_Mutation_p.R193S|SLC2A2_uc011bpu.1_Missense_Mutation_p.R239S	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	366	Cytoplasmic (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			AAGAGAGAACGTCGCCCTGCC	0.398													39	107					2.54651e-27	3.9386e-27	1	0
SDHAP2	727956	broad.mit.edu	37	3	195410687	195410687	+	Missense_Mutation	SNP	T	A	A	rs6583274	by1000genomes	TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr3:195410687T>A	uc003fuw.2	+	13	1778	c.584T>A	c.(583-585)GTG>GAG	p.V195E	SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						CCCTTTGAGGTGCACTGGAGG	0.567													3	33					0	0	0	0
TECRL	253017	broad.mit.edu	37	4	65147243	65147243	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr4:65147243G>A	uc003hcv.2	-	10	976	c.867C>T	c.(865-867)AAC>AAT	p.N289N	TECRL_uc010ihi.2_RNA	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	289					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						ATGTGAAGGGGTTATAATTTG	0.328													19	7					0	0	0	0
NUDT9	53343	broad.mit.edu	37	4	88344060	88344060	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr4:88344060G>A	uc003hqq.2	+	1	326	c.3G>A	c.(1-3)ATG>ATA	p.M1I	NUDT9_uc003hqr.2_Intron|NUDT9_uc010ikl.2_Missense_Mutation_p.M1I	NM_024047	NP_076952	Q9BW91	NUDT9_HUMAN	nudix-type motif 9 isoform a	1						mitochondrion	ADP-ribose diphosphatase activity				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000937)		GGGCGCTCATGGCGGGACGCC	0.672													32	52					0	0	0	0
ANKRD50	57182	broad.mit.edu	37	4	125600031	125600031	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr4:125600031T>G	uc003ifg.3	-	2	808	c.542A>C	c.(541-543)AAG>ACG	p.K181T	ANKRD50_uc011cgo.1_Missense_Mutation_p.K2T|ANKRD50_uc010inw.2_Missense_Mutation_p.K181T	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	181										central_nervous_system(1)	1						CTGGGGAGGCTTCATTCCCAG	0.398													3	99					0	0	0	0
PCDH10	57575	broad.mit.edu	37	4	134072226	134072226	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr4:134072226G>C	uc003iha.2	+	1	1757	c.931G>C	c.(931-933)GAG>CAG	p.E311Q	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.E311Q	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	311	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TGGCAGACTGGAGGTAAGCGG	0.632													37	23					0	0	0	0
NPY5R	4889	broad.mit.edu	37	4	164272687	164272687	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr4:164272687A>G	uc003iqn.2	+	4	1444	c.1262A>G	c.(1261-1263)AAT>AGT	p.N421S		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	421	Helical; Name=7; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				TGTTGTCTTAATCCAATTCTA	0.328													45	20					0	0	0	0
CEP72	55722	broad.mit.edu	37	5	637653	637653	+	Missense_Mutation	SNP	C	T	T	rs143077618		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:637653C>T	uc003jbf.2	+	7	998	c.926C>T	c.(925-927)TCG>TTG	p.S309L	CEP72_uc011clz.1_RNA	NM_018140	NP_060610	Q9P209	CEP72_HUMAN	centrosomal protein 72 kDa	309					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			ACCGAGGACTCGGCCTCTTCT	0.527													28	50					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13719184	13719184	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:13719184G>T	uc003jfd.2	-	72	12348	c.12306C>A	c.(12304-12306)TGC>TGA	p.C4102*	DNAH5_uc003jfc.2_Nonsense_Mutation_p.C270*	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4102	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GTCCCAGATGGCAGTTCTGCA	0.418									Kartagener_syndrome				22	29					1.10513e-12	1.48489e-12	1	0
FBXL7	23194	broad.mit.edu	37	5	15616151	15616151	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:15616151A>G	uc003jfn.1	+	2	578	c.97A>G	c.(97-99)AAA>GAA	p.K33E		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	33					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CACGCCCACTAAAGCCCAGAA	0.453													10	25					0	0	0	0
CDH9	1007	broad.mit.edu	37	5	26885803	26885803	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:26885803G>T	uc003jgs.1	-	11	1971	c.1802C>A	c.(1801-1803)ACC>AAC	p.T601N	CDH9_uc011cnv.1_Missense_Mutation_p.T194N	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	601	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						GGCTTCTGCGGTGCAGGATTG	0.488													6	20					5.9392e-07	7.32923e-07	1	0
DAB2	1601	broad.mit.edu	37	5	39376143	39376143	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:39376143C>G	uc003jlx.2	-	13	2734	c.2203G>C	c.(2203-2205)GAG>CAG	p.E735Q	DAB2_uc003jlw.2_Missense_Mutation_p.E714Q	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	735	Required for interaction with MYO6 (By similarity).				cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			AAAGGGTTCTCAAATGCATTG	0.418													19	36					0	0	0	0
MAST4	375449	broad.mit.edu	37	5	66429471	66429471	+	Silent	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:66429471A>G	uc003jut.1	+	16	1724	c.1656A>G	c.(1654-1656)AAA>AAG	p.K552K	MAST4_uc003juu.1_Silent_p.K562K|MAST4_uc011cra.1_Silent_p.K535K|MAST4_uc003juv.2_Silent_p.K547K|MAST4_uc003juw.2_Silent_p.K547K	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	744	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		TCCTGGATAAACAGGTAAGCT	0.408													21	37					0	0	0	0
GIN1	54826	broad.mit.edu	37	5	102423676	102423676	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:102423676C>A	uc003koa.1	-	8	1577	c.1495G>T	c.(1495-1497)GAT>TAT	p.D499Y	GIN1_uc003kob.1_Missense_Mutation_p.D352Y|GIN1_uc003koc.1_3'UTR	NM_017676	NP_060146	Q9NXP7	GIN1_HUMAN	zinc finger, H2C2 domain containing	499					DNA integration		DNA binding			ovary(1)|skin(1)	2		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		GAACTATGATCGTCTATCAAT	0.318													33	53					3.80469e-20	5.65826e-20	1	0
APC	324	broad.mit.edu	37	5	112151205	112151205	+	Missense_Mutation	SNP	G	A	A	rs149154604		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:112151205G>A	uc010jby.2	+	9	1228	c.848G>A	c.(847-849)CGA>CAA	p.R283Q	APC_uc011cvt.1_Missense_Mutation_p.R265Q|APC_uc003kpz.3_Missense_Mutation_p.R283Q|APC_uc003kpy.3_Missense_Mutation_p.R283Q|APC_uc010jbz.2_5'UTR	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	283	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.R283*(7)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TCAACTACACGAATGGACCAT	0.383		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			17	31					0	0	0	0
KCNN2	3781	broad.mit.edu	37	5	113831815	113831815	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:113831815G>T	uc003kqo.2	+	8	2133	c.1676G>T	c.(1675-1677)CGG>CTG	p.R559L	KCNN2_uc003kqp.2_Missense_Mutation_p.R211L|KCNN2_uc010jcg.2_RNA|uc003kqr.1_RNA	NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	559						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		GAGCGGTCCCGGTCCTCGTCC	0.512													31	74					2.08457e-15	2.90172e-15	1	0
PCDHB15	56121	broad.mit.edu	37	5	140627413	140627413	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:140627413C>A	uc003lje.2	+	1	2267	c.2267C>A	c.(2266-2268)ACG>AAG	p.T756K		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	756	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTGTGTCTGACGGGAGGCTCT	0.517													71	120					4.98182e-18	7.22364e-18	1	0
PCDHGA2	56113	broad.mit.edu	37	5	140718609	140718609	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:140718609G>T	uc003ljk.1	+	1	256	c.71G>T	c.(70-72)TGG>TTG	p.W24L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.W24L	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	24					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGACCCTGTGGGAGGCCAGG	0.577											OREG0016854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	42					1.67942e-08	2.10988e-08	1	0
PCDHGB3	56102	broad.mit.edu	37	5	140751081	140751081	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:140751081C>A	uc003ljw.1	+	1	1120	c.1120C>A	c.(1120-1122)CTA>ATA	p.L374I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.L374I|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	374	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACACATGATCTAGATTCTGG	0.423													7	24					0.00198382	0.00234023	1	0
PCDHGA9	56107	broad.mit.edu	37	5	140784798	140784798	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:140784798C>A	uc003lkh.1	+	1	2279	c.2279C>A	c.(2278-2280)ACC>AAC	p.T760N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.T760N|PCDHGB6_uc003lki.1_5'Flank|PCDHGB6_uc003lkj.1_5'Flank	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	760	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTCCCTCACCGCTGACTCA	0.537													44	83					1.48734e-19	2.20252e-19	1	0
PCDHGB7	56099	broad.mit.edu	37	5	140797510	140797510	+	Silent	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:140797510G>T	uc003lkn.1	+	1	229	c.84G>T	c.(82-84)ACG>ACT	p.T28T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Silent_p.T28T	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	28					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTACCCCACGCTGTGTGAGC	0.527											OREG0016863	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	23					5.50884e-06	6.70306e-06	1	0
PANK3	79646	broad.mit.edu	37	5	168006280	168006280	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:168006280G>A	uc003lzz.1	-	1	309	c.9C>T	c.(7-9)ATC>ATT	p.I3I		NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3	3					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		TGGCATCTTTGATCTTCATGG	0.706													6	9					0	0	0	0
STK10	6793	broad.mit.edu	37	5	171488156	171488156	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr5:171488156C>A	uc003mbo.1	-	14	2499	c.2199G>T	c.(2197-2199)CAG>CAT	p.Q733H		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	733	Potential.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAAGGAGCTCCTGCTTCTTCA	0.617													71	140					9.12251e-31	1.43649e-30	1	0
ABT1	29777	broad.mit.edu	37	6	26597372	26597372	+	Silent	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr6:26597372G>T	uc003nii.2	+	1	193	c.162G>T	c.(160-162)CCG>CCT	p.P54P		NM_013375	NP_037507	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	54	RRM.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			ovary(1)	1						GCCATATCCCGCCGCGCTTCC	0.612													16	28					2.32078e-09	2.96924e-09	1	0
TRIM39	56658	broad.mit.edu	37	6	30297275	30297275	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr6:30297275G>A	uc010jrz.2	+	3	493	c.181G>A	c.(181-183)GAG>AAG	p.E61K	HCG18_uc003npx.2_5'Flank|HCG18_uc003npy.2_5'Flank|TRIM39_uc003npz.2_Missense_Mutation_p.E61K|TRIM39_uc003nqb.2_Missense_Mutation_p.E61K|TRIM39_uc003nqc.2_Missense_Mutation_p.E61K|TRIM39_uc010jsa.1_Missense_Mutation_p.E61K	NM_021253	NP_067076	Q9HCM9	TRI39_HUMAN	tripartite motif-containing 39 isoform 1	61	RING-type.				apoptosis	cytosol|mitochondrion	identical protein binding|zinc ion binding			ovary(3)	3						GGAGGACCTAGAGAGGGACTT	0.542													48	83					0	0	0	0
PBX2	5089	broad.mit.edu	37	6	32154610	32154610	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr6:32154610C>T	uc003oav.1	-	7	1364	c.1093G>A	c.(1093-1095)GAT>AAT	p.D365N	AGER_uc003oar.2_5'Flank|AGER_uc011dpm.1_5'Flank|AGER_uc011dpn.1_5'Flank|AGER_uc003oal.1_5'Flank|AGER_uc010jtv.1_5'Flank|AGER_uc011dpo.1_5'Flank|AGER_uc003oam.1_5'Flank|AGER_uc003oan.1_5'Flank|AGER_uc003oap.1_5'Flank|AGER_uc003oat.1_5'Flank|AGER_uc003oao.1_5'Flank|AGER_uc003oaq.1_5'Flank|AGER_uc010jtw.1_5'Flank|AGER_uc003oas.1_5'Flank|AGER_uc003oau.1_5'Flank|AGER_uc011dpp.1_5'Flank|AGER_uc011dpq.1_5'Flank|AGER_uc011dpr.1_5'Flank|AGER_uc011dps.1_5'Flank	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	365							transcription factor binding			ovary(1)	1						GAATAGGAATCTCCGTTGAGC	0.512													30	55					0	0	0	0
APOBEC2	10930	broad.mit.edu	37	6	41029194	41029194	+	Silent	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr6:41029194C>A	uc003opl.2	+	2	406	c.259C>A	c.(259-261)CGG>AGG	p.R87R	UNC5CL_uc010jxe.1_Intron|APOBEC2_uc010jxf.2_Intron	NM_006789	NP_006780	Q9Y235	ABEC2_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	87					DNA demethylation|mRNA processing		cytidine deaminase activity|RNA binding|zinc ion binding				0	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCAGGCATCTCGGGGATACCT	0.567													36	82					4.34311e-12	5.76871e-12	1	0
HCRTR2	3062	broad.mit.edu	37	6	55113511	55113511	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr6:55113511G>T	uc003pcl.2	+	2	613	c.298G>T	c.(298-300)GAT>TAT	p.D100Y	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Missense_Mutation_p.D35Y	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	100	Helical; Name=2; (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TTCTCTGGCTGATGTGCTCGT	0.453													56	102					6.4308e-24	9.77257e-24	1	0
COL19A1	1310	broad.mit.edu	37	6	70856592	70856592	+	Silent	SNP	A	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr6:70856592A>T	uc003pfc.1	+	26	1929	c.1812A>T	c.(1810-1812)CCA>CCT	p.P604P	COL19A1_uc010kam.1_Silent_p.P500P	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	604	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						CACGTGGGCCAAAGGTATACA	0.323													5	11					0	0	0	0
SPACA1	81833	broad.mit.edu	37	6	88763681	88763681	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr6:88763681G>C	uc003pmn.2	+	2	343	c.226G>C	c.(226-228)GTC>CTC	p.V76L		NM_030960	NP_112222	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1 precursor	76	Extracellular (Potential).					integral to membrane					0		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		TAGGAATGTCGTCAAAGAAGT	0.348													8	20					0	0	0	0
ROS1	6098	broad.mit.edu	37	6	117683782	117683782	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr6:117683782C>A	uc003pxp.1	-	21	3564	c.3365G>T	c.(3364-3366)TGC>TTC	p.C1122F	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1122	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GGCAATAAAGCATCTGGGACT	0.408			T	GOPC|ROS1	glioblastoma|NSCLC								12	26					0.00010058	0.000120281	1	0
ROS1	6098	broad.mit.edu	37	6	117709005	117709005	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr6:117709005G>A	uc003pxp.1	-	13	2151	c.1952C>T	c.(1951-1953)GCA>GTA	p.A651V	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	651	Fibronectin type-III 3.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TGGAGAACTTGCTCTCACAGA	0.488			T	GOPC|ROS1	glioblastoma|NSCLC								50	70					0	0	0	0
THEMIS	387357	broad.mit.edu	37	6	128222065	128222065	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr6:128222065G>T	uc003qbi.2	-	2	332	c.13C>A	c.(13-15)CTG>ATG	p.L5M	THEMIS_uc011ebt.1_Missense_Mutation_p.L5M|THEMIS_uc010kfb.2_Intron	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	5	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						AATTCTTCCAGTGATAATGCC	0.498													51	69					9.57592e-29	1.49436e-28	1	0
ENPP3	5169	broad.mit.edu	37	6	132061454	132061454	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr6:132061454C>T	uc003qcu.3	+	25	2738	c.2391C>T	c.(2389-2391)TGC>TGT	p.C797C	ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Silent_p.C797C	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	797	Extracellular (Potential).|Nuclease.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		CGGAAAACTGCCCTGGGTGGC	0.512													31	50					0	0	0	0
KIAA1244	57221	broad.mit.edu	37	6	138601217	138601217	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr6:138601217G>A	uc003qhu.2	+	14	2377	c.2377G>A	c.(2377-2379)GTG>ATG	p.V793M		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	793	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CTACCATCAGGTGCTCGACAG	0.552													28	29					0	0	0	0
PDE10A	10846	broad.mit.edu	37	6	165957010	165957010	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr6:165957010C>A	uc003qun.2	-	3	325	c.84G>T	c.(82-84)CAG>CAT	p.Q28H	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Translation_Start_Site|PDE10A_uc003quo.2_Missense_Mutation_p.Q38H	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	28					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CATCTAATACCTGGGGGTGAA	0.358													18	28					5.03518e-11	6.58738e-11	1	0
STK31	56164	broad.mit.edu	37	7	23827673	23827673	+	Silent	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:23827673A>G	uc003sws.3	+	21	2629	c.2562A>G	c.(2560-2562)TCA>TCG	p.S854S	STK31_uc003swt.3_Silent_p.S831S|STK31_uc011jze.1_Silent_p.S854S|STK31_uc010kuq.2_Silent_p.S831S|STK31_uc003swv.1_Silent_p.S20S	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	854	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TTCATGGATCACTTCATCAGA	0.353													33	93					0	0	0	0
STK31	56164	broad.mit.edu	37	7	23871841	23871841	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:23871841C>T	uc003sws.3	+	24	2983	c.2916C>T	c.(2914-2916)TTC>TTT	p.F972F	STK31_uc003swt.3_Silent_p.F949F|STK31_uc011jze.1_Silent_p.F949F|STK31_uc010kuq.2_Silent_p.F949F|STK31_uc003swv.1_Silent_p.F138F	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	972	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						CTGAATGTTTCTTGATGCCAA	0.353													68	60					0	0	0	0
INHBA	3624	broad.mit.edu	37	7	41739824	41739824	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:41739824G>T	uc003thq.2	-	1	384	c.149C>A	c.(148-150)TCT>TAT	p.S50Y	LOC285954_uc003tht.3_Intron|INHBA_uc003thr.2_Missense_Mutation_p.S50Y|LOC285954_uc003ths.2_Intron	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	50					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						CTCTGGCTGAGAGTTGGGTAC	0.612										TSP Lung(11;0.080)			187	256					7.59282e-81	1.25228e-80	1	0
ZNF716	441234	broad.mit.edu	37	7	57529071	57529071	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:57529071G>T	uc011kdi.1	+	4	1016	c.904G>T	c.(904-906)GGC>TGC	p.G302C		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						TGAAGAATGTGGCAAAGCCTT	0.418													8	16					0.00307968	0.00360851	1	0
ZNF117	51351	broad.mit.edu	37	7	64452342	64452342	+	5'Flank	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:64452342C>A	uc003ttr.2	-						ZNF117_uc011kdr.1_Missense_Mutation_p.D352Y	NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				cctactgggtctgtaaaggcc	0													13	31					3.03607e-14	4.19267e-14	1	0
WBSCR17	64409	broad.mit.edu	37	7	71142291	71142291	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:71142291G>T	uc003tvy.2	+	9	1500	c.1500G>T	c.(1498-1500)CAG>CAT	p.Q500H	WBSCR17_uc003tvz.2_Missense_Mutation_p.Q199H	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	500	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GGGGACCACAGGTAGGAGCTC	0.537													61	111					1.03172e-35	1.66222e-35	1	0
PCLO	27445	broad.mit.edu	37	7	82582174	82582174	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:82582174G>T	uc003uhx.2	-	5	8384	c.8095C>A	c.(8095-8097)CCT>ACT	p.P2699T	PCLO_uc003uhv.2_Missense_Mutation_p.P2699T|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2630					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGCTCTGGAGGAATTGTTATG	0.403													18	47					3.32936e-07	4.12319e-07	1	0
ZNF804B	219578	broad.mit.edu	37	7	88847532	88847532	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:88847532G>T	uc011khi.1	+	2	710	c.172G>T	c.(172-174)GAA>TAA	p.E58*		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	58	C2H2-type.					intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CTTTTACTGTGAATTATGTGA	0.368										HNSCC(36;0.09)			26	29					1.1804e-14	1.63657e-14	1	0
CCDC132	55610	broad.mit.edu	37	7	92887685	92887685	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:92887685G>T	uc003umo.2	+	8	685	c.557G>T	c.(556-558)CGG>CTG	p.R186L	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.R156L|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Intron|CCDC132_uc003umn.2_Missense_Mutation_p.R186L	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	186											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			ACAGATGTACGGTTAAGTGAA	0.299													20	52					3.5997e-14	4.95136e-14	1	0
PPP1R9A	55607	broad.mit.edu	37	7	94791279	94791279	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:94791279G>A	uc003unp.2	+	5	2032	c.1750G>A	c.(1750-1752)GTC>ATC	p.V584I	PPP1R9A_uc010lfj.2_Missense_Mutation_p.V584I|PPP1R9A_uc011kif.1_Missense_Mutation_p.V584I|PPP1R9A_uc003unq.2_Missense_Mutation_p.V584I|PPP1R9A_uc011kig.1_Missense_Mutation_p.V584I	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	584	PDZ.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			CAAGGGCAACGTCAGGTAAAT	0.363										HNSCC(28;0.073)			5	3					0	0	0	0
TRRAP	8295	broad.mit.edu	37	7	98581764	98581764	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:98581764A>G	uc003upp.2	+	60	9292	c.9083A>G	c.(9082-9084)AAT>AGT	p.N3028S	TRRAP_uc011kis.1_Missense_Mutation_p.N2999S|TRRAP_uc003upr.2_Missense_Mutation_p.N2716S	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3028	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CCCAGTTCAAATAACGCTATG	0.448													43	62					0	0	0	0
Unknown	0	broad.mit.edu	37	7	100551864	100551864	+	RNA	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:100551864C>G	uc003uxk.1	+	1		c.1115C>G			uc003uxl.1_Silent_p.L105L					Homo sapiens MUC3B mRNA for intestinal mucin, partial cds.																		AAACTTCACTCACATCTACAA	0.438													56	515					0	0	0	0
MET	4233	broad.mit.edu	37	7	116339752	116339752	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:116339752A>G	uc003vij.2	+	2	801	c.614A>G	c.(613-615)TAT>TGT	p.Y205C	MET_uc010lkh.2_Missense_Mutation_p.Y205C|MET_uc011knc.1_Missense_Mutation_p.Y205C|MET_uc011knd.1_Missense_Mutation_p.Y205C|MET_uc011kne.1_Missense_Mutation_p.Y205C|MET_uc011knf.1_Missense_Mutation_p.Y205C|MET_uc011kng.1_Missense_Mutation_p.Y205C|MET_uc011knh.1_Missense_Mutation_p.Y205C|MET_uc011kni.1_Missense_Mutation_p.Y205C|MET_uc003vii.1_Missense_Mutation_p.Y224C|MET_uc010lkg.2_Missense_Mutation_p.Y205C|MET_uc011kmz.1_Missense_Mutation_p.Y205C|MET_uc011kna.1_Missense_Mutation_p.Y205C|MET_uc011knb.1_Missense_Mutation_p.Y205C	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	205	Extracellular (Potential).|Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AATTCTTCTTATTTCCCAGAT	0.418			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				67	89					0	0	0	0
Unknown	0	broad.mit.edu	37	7	124116548	124116548	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:124116548G>C	uc011kod.1	+	1	124	c.124G>C	c.(124-126)GTG>CTG	p.V42L		NM_001085395	NP_001078864			RecName: Full=Putative RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like protein 2;          Short=CTD phosphatase SSU72-like protein 2;          EC=3.1.3.16;																		TGAATCTCATGTGAGGCTACC	0.478													68	103					0	0	0	0
GRM8	2918	broad.mit.edu	37	7	126544151	126544151	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:126544151T>C	uc003vlr.2	-	4	1204	c.893A>G	c.(892-894)AAC>AGC	p.N298S	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.N298S|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Missense_Mutation_p.N19S	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	298	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CCCACTTTGGTTTAGTTTTTT	0.368										HNSCC(24;0.065)			42	60					0	0	0	0
MGAM	8972	broad.mit.edu	37	7	141755884	141755884	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:141755884A>C	uc003vwy.2	+	29	3622	c.3568A>C	c.(3568-3570)AGC>CGC	p.S1190R		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1190	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCTGCTGAACAGCAATGCCAT	0.512													8	3					0	0	0	0
GALNTL5	168391	broad.mit.edu	37	7	151699803	151699803	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr7:151699803T>A	uc003wkp.2	+	6	886	c.663T>A	c.(661-663)GAT>GAA	p.D221E	GALNTL5_uc003wkq.2_5'UTR|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Missense_Mutation_p.D110E	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	221	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		CCCCAGGGGATGTTCTGGTGT	0.498													25	12					0	0	0	0
MSC	9242	broad.mit.edu	37	8	72754902	72754902	+	Silent	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr8:72754902G>T	uc003xyx.1	-	2	933	c.615C>A	c.(613-615)ACC>ACA	p.T205T	uc011lff.1_5'Flank|uc003xyy.2_5'Flank	NM_005098	NP_005089	O60682	MUSC_HUMAN	musculin	205					transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			CGATTTAAGCGGTGGTTCCAC	0.493													200	317					3.50731e-122	5.868e-122	1	0
PSKH2	85481	broad.mit.edu	37	8	87060915	87060915	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr8:87060915C>G	uc011lfy.1	-	3	934	c.934G>C	c.(934-936)GGC>CGC	p.G312R		NM_033126	NP_149117	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	312	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|lung(2)|ovary(1)	5			STAD - Stomach adenocarcinoma(118;0.129)			AGGGCCTGGCCAGCTGACATG	0.512													36	49					0	0	0	0
CDH17	1015	broad.mit.edu	37	8	95174380	95174380	+	Silent	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr8:95174380G>T	uc003ygh.2	-	11	1418	c.1293C>A	c.(1291-1293)ACC>ACA	p.T431T	CDH17_uc011lgo.1_Silent_p.T217T|CDH17_uc011lgp.1_Silent_p.T431T	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	431	Extracellular (Potential).|Cadherin 4.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CAAAACAAAGGGTCTTGAAAT	0.313													13	30					6.72482e-11	8.76494e-11	1	0
PGCP	10404	broad.mit.edu	37	8	97978226	97978226	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr8:97978226G>A	uc003yhw.2	+	5	1079	c.913G>A	c.(913-915)GGT>AGT	p.G305S	PGCP_uc010mbe.2_Missense_Mutation_p.G305S	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	305					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					GGATGATGGCGGTGGAGCCTT	0.378													3	56					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110451290	110451290	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr8:110451290G>A	uc003yne.2	+	32	4029	c.3925G>A	c.(3925-3927)GAA>AAA	p.E1309K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1309	Extracellular (Potential).|IPT/TIG 6.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TATCTATGTAGAAGTCAGAAA	0.398										HNSCC(38;0.096)			64	106					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110476802	110476802	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr8:110476802C>A	uc003yne.2	+	49	7845	c.7741C>A	c.(7741-7743)CAC>AAC	p.H2581N		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2581	Extracellular (Potential).|PbH1 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGGTGGCACTCACTTTGGCTT	0.463										HNSCC(38;0.096)			24	35					2.21704e-12	2.96742e-12	1	0
CSMD3	114788	broad.mit.edu	37	8	113246662	113246662	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr8:113246662G>T	uc003ynu.2	-	68	10831	c.10672C>A	c.(10672-10674)CTT>ATT	p.L3558I	CSMD3_uc003yns.2_Missense_Mutation_p.L2760I|CSMD3_uc003ynt.2_Missense_Mutation_p.L3518I|CSMD3_uc011lhx.1_Missense_Mutation_p.L3389I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3558	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACTTTAATAAGATATATGCGT	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			50	95					1.4374e-25	2.20359e-25	1	0
CSMD3	114788	broad.mit.edu	37	8	113697930	113697930	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr8:113697930C>A	uc003ynu.2	-	15	2346	c.2187G>T	c.(2185-2187)ATG>ATT	p.M729I	CSMD3_uc003yns.2_Missense_Mutation_p.M1I|CSMD3_uc003ynt.2_Missense_Mutation_p.M689I|CSMD3_uc011lhx.1_Missense_Mutation_p.M625I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	729	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GAACTGTTCCCATTGGTGCAG	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			27	64					1.74197e-06	2.12704e-06	1	0
ZHX2	22882	broad.mit.edu	37	8	123965602	123965602	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr8:123965602T>C	uc003ypk.1	+	3	2419	c.1852T>C	c.(1852-1854)TCC>CCC	p.S618P		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	618						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			CGACCAGCTCTCCGGTGCCCA	0.532													25	52					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139151251	139151251	+	Silent	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr8:139151251G>C	uc003yuy.2	-	18	4050	c.3879C>G	c.(3877-3879)CTC>CTG	p.L1293L	FAM135B_uc003yux.2_Silent_p.L1194L|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1293										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTAGTTGGTAGAGGAAACATT	0.438										HNSCC(54;0.14)			12	127					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139165165	139165165	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr8:139165165C>A	uc003yuy.2	-	13	1724	c.1553G>T	c.(1552-1554)TGT>TTT	p.C518F	FAM135B_uc003yux.2_Missense_Mutation_p.C419F|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.C80F|FAM135B_uc003yvb.2_Missense_Mutation_p.C80F	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	518										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCCAGTCCAACATTCATCTTC	0.463										HNSCC(54;0.14)			41	165					2.24893e-16	3.18142e-16	1	0
CYP11B2	1585	broad.mit.edu	37	8	143994844	143994844	+	Silent	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr8:143994844C>A	uc003yxk.1	-	6	981	c.978G>T	c.(976-978)ACG>ACT	p.T326T		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	326					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GCTCAAAGAGCGTCATCAGCA	0.622									Familial_Hyperaldosteronism_type_I				27	151					3.73148e-12	4.9753e-12	1	0
NAPRT1	93100	broad.mit.edu	37	8	144658323	144658323	+	Silent	SNP	C	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr8:144658323C>A	uc003yym.3	-	8	1057	c.1032G>T	c.(1030-1032)GTG>GTT	p.V344V	NAPRT1_uc003yyn.3_Silent_p.V344V|NAPRT1_uc011lkh.1_Silent_p.V344V|NAPRT1_uc003yyo.3_Silent_p.V344V	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	344					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CCAGCCAGGGCACCTGGAACC	0.667													20	34					7.41877e-09	9.42238e-09	1	0
DENND4C	55667	broad.mit.edu	37	9	19316463	19316463	+	Silent	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr9:19316463G>T	uc003znq.2	+	7	861	c.828G>T	c.(826-828)CCG>CCT	p.P276P	DENND4C_uc011lnc.1_5'UTR	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	276						integral to membrane				ovary(1)|skin(1)	2						CCAAAAAGCCGTGCAAAAATC	0.328													11	2					7.03913e-09	8.97295e-09	1	0
FAM75A6	389730	broad.mit.edu	37	9	43626706	43626706	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr9:43626706T>A	uc011lrb.1	-	4	2010	c.1981A>T	c.(1981-1983)AGG>TGG	p.R661W		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	661						integral to membrane					0						CACAGGTCCCTCTCTAGCTGG	0.562													71	13					0	0	0	0
PGM5	5239	broad.mit.edu	37	9	71098829	71098829	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr9:71098829G>T	uc004agr.2	+	9	1573	c.1344G>T	c.(1342-1344)AGG>AGT	p.R448S		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	448					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						ATATCATGAGGGACCTGGAGG	0.507													29	57					7.38237e-10	9.47994e-10	1	0
IARS	3376	broad.mit.edu	37	9	95009669	95009669	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr9:95009669G>T	uc004art.1	-	26	3038	c.2781C>A	c.(2779-2781)TTC>TTA	p.F927L	IARS_uc004ars.1_Missense_Mutation_p.F772L|IARS_uc004aru.3_Missense_Mutation_p.F927L|IARS_uc010mqr.2_Missense_Mutation_p.F817L|IARS_uc010mqt.2_Missense_Mutation_p.F150L	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	927					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	CAGTCTTCTGGAACTGCTCCA	0.473													24	53					2.24059e-21	3.36089e-21	1	0
LOC441454	441454	broad.mit.edu	37	9	99672508	99672508	+	RNA	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr9:99672508G>C	uc011luq.1	+	1		c.1152G>C				NR_028350				Homo sapiens prothymosin, alpha pseudogene (LOC441454), non-coding RNA.												0						GGCTGACAAGGAGGTagatga	0.294													4	14					0	0	0	0
BAAT	570	broad.mit.edu	37	9	104133542	104133542	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr9:104133542G>A	uc010mtd.2	-	2	254	c.145C>T	c.(145-147)CAC>TAC	p.H49Y	BAAT_uc004bbd.3_Missense_Mutation_p.H49Y	NM_001127610	NP_001121082	Q14032	BAAT_HUMAN	bile acid Coenzyme A: amino acid	49					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			ovary(1)|lung(1)|skin(1)	3		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	GCCCTATAGTGGGCTTGAGAA	0.488													33	68					0	0	0	0
OR1N2	138882	broad.mit.edu	37	9	125315511	125315511	+	Silent	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr9:125315511G>C	uc011lyx.1	+	1	63	c.63G>C	c.(61-63)GTG>GTC	p.V21V		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						CAGGCAGAGTGAACCAAACCA	0.423													39	59					0	0	0	0
SDCCAG3	10807	broad.mit.edu	37	9	139301763	139301763	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr9:139301763G>A	uc004chi.2	-	5	858	c.653C>T	c.(652-654)CCG>CTG	p.P218L	SDCCAG3_uc004chj.2_Missense_Mutation_p.P195L|SDCCAG3_uc004chk.2_Missense_Mutation_p.P145L	NM_001039707	NP_001034796	Q96C92	SDCG3_HUMAN	serologically defined colon cancer antigen 3	218						cytoplasm					0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		CAGCTCCGACGGGGTGGAGAA	0.657													11	8					0	0	0	0
MAMDC4	158056	broad.mit.edu	37	9	139754408	139754408	+	Silent	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr9:139754408G>A	uc004cjs.2	+	26	3314	c.3264G>A	c.(3262-3264)GTG>GTA	p.V1088V	MAMDC4_uc011mej.1_Silent_p.V425V	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	1167	Helical; (Potential).				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		TGCTCCTGGTGCTGCTGGGAC	0.627													24	29					0	0	0	0
NELF	26012	broad.mit.edu	37	9	140346851	140346851	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr9:140346851C>G	uc004cna.2	-	12	1434	c.1202G>C	c.(1201-1203)GGA>GCA	p.G401A	C9orf167_uc011mew.1_Intron|NELF_uc011mex.1_Missense_Mutation_p.G198A|NELF_uc010nci.2_Missense_Mutation_p.G145A|NELF_uc011mey.1_RNA|NELF_uc011mez.1_Missense_Mutation_p.G378A|NELF_uc004cmz.2_Missense_Mutation_p.G399A|NELF_uc004cnc.2_Missense_Mutation_p.G376A|NELF_uc004cnb.2_Missense_Mutation_p.G371A	NM_001130969	NP_001124441	Q6X4W1	NELF_HUMAN	nasal embryonic LHRH factor isoform a	401						nucleus|plasma membrane					0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000222)|Epithelial(140;0.000888)		GATCTTGGCTCCCTTGTGGTA	0.617													59	121					0	0	0	0
HDHD1A	8226	broad.mit.edu	37	X	7023726	7023726	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chrX:7023726T>C	uc004crv.2	-	2	292	c.215A>G	c.(214-216)GAG>GGG	p.E72G	HDHD1A_uc011mhm.1_Missense_Mutation_p.E95G|HDHD1A_uc011mhn.1_Intron|HDHD1A_uc010ndl.2_Missense_Mutation_p.E72G|HDHD1A_uc011mho.1_Missense_Mutation_p.E72G	NM_012080	NP_036212	Q08623	HDHD1_HUMAN	haloacid dehalogenase-like hydrolase domain	72					nucleotide metabolic process		metal ion binding|phosphatase activity				0		Colorectal(8;0.0114)|Medulloblastoma(8;0.184)				CACCAGCTCCTCTTTGGACAT	0.502													16	0					0	0	0	0
CNKSR2	22866	broad.mit.edu	37	X	21627262	21627262	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chrX:21627262C>G	uc004czx.1	+	20	2255	c.2219C>G	c.(2218-2220)TCT>TGT	p.S740C	CNKSR2_uc004czw.2_Missense_Mutation_p.S740C|CNKSR2_uc011mjn.1_Missense_Mutation_p.S691C|CNKSR2_uc011mjo.1_Missense_Mutation_p.S710C|CNKSR2_uc004czy.2_Missense_Mutation_p.S332C	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	740					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						CAGTCTCAGTCTTCTCATGAG	0.517													34	10					0	0	0	0
YY2	404281	broad.mit.edu	37	X	21869684	21869684	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chrX:21869684A>T	uc010nfq.2	+	4	693	c.496A>T	c.(496-498)ATT>TTT	p.I166F	MBTPS2_uc004dae.2_Missense_Mutation_p.I166F|MBTPS2_uc010nfr.2_5'Flank|MBTPS2_uc004dab.2_Missense_Mutation_p.I166F	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	Error:Variant_position_missing_in_O15391_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GGCAGTTCTCATTAGTGGTGT	0.373													5	78					0	0	0	0
DMD	1756	broad.mit.edu	37	X	32328320	32328320	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chrX:32328320G>A	uc004dda.1	-	42	6240	c.5996C>T	c.(5995-5997)ACT>ATT	p.T1999I	DMD_uc004dcw.2_Missense_Mutation_p.T655I|DMD_uc004dcx.2_Missense_Mutation_p.T658I|DMD_uc004dcz.2_Missense_Mutation_p.T1876I|DMD_uc004dcy.1_Missense_Mutation_p.T1995I|DMD_uc004ddb.1_Missense_Mutation_p.T1991I|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1999					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGTCAAATAAGTAGAAGGCAC	0.393													21	7					0	0	0	0
DMD	1756	broad.mit.edu	37	X	32404497	32404497	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chrX:32404497G>T	uc004dda.1	-	33	4848	c.4604C>A	c.(4603-4605)ACG>AAG	p.T1535K	DMD_uc004dcw.2_Missense_Mutation_p.T191K|DMD_uc004dcx.2_Missense_Mutation_p.T194K|DMD_uc004dcz.2_Missense_Mutation_p.T1412K|DMD_uc004dcy.1_Missense_Mutation_p.T1531K|DMD_uc004ddb.1_Missense_Mutation_p.T1527K|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1535	Spectrin 10.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGGATTTTCCGTCTGCTTTTT	0.383													49	13					2.43139e-17	3.46772e-17	1	0
KDM6A	7403	broad.mit.edu	37	X	44938390	44938390	+	Splice_Site	SNP	G	C	C			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chrX:44938390G>C	uc004dge.3	+	20	3314	c.2939_splice	c.e20-1	p.D980_splice	KDM6A_uc010nhk.2_Splice_Site_p.D946_splice|KDM6A_uc011mkz.1_Splice_Site_p.D1032_splice|KDM6A_uc011mla.1_Splice_Site_p.D935_splice|KDM6A_uc011mlb.1_Splice_Site_p.D987_splice|KDM6A_uc011mlc.1_Splice_Site_p.D684_splice|KDM6A_uc011mld.1_Splice_Site_p.D619_splice	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TATTCATGAAGACCTGGGACT	0.328			D|N|F|S		renal|oesophageal SCC|MM								11	1					0	0	0	0
DRP2	1821	broad.mit.edu	37	X	100494001	100494001	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chrX:100494001C>T	uc004egz.2	+	6	839	c.470C>T	c.(469-471)CCC>CTC	p.P157L	DRP2_uc011mrh.1_Missense_Mutation_p.P79L	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	157	Spectrin 1.				central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						TCTCGGGGCCCCTACATCTAT	0.463													58	16					0	0	0	0
CAPN6	827	broad.mit.edu	37	X	110491846	110491846	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chrX:110491846T>G	uc004epc.1	-	10	1603	c.1435A>C	c.(1435-1437)ACC>CCC	p.T479P	CAPN6_uc011msu.1_Missense_Mutation_p.T224P	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	479	Domain III.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						AACTCGCTGGTGCGACCATGC	0.502													15	4					0	0	0	0
ALG13	79868	broad.mit.edu	37	X	110924494	110924494	+	Silent	SNP	C	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chrX:110924494C>T	uc011msy.1	+	1	82	c.48C>T	c.(46-48)CTC>CTT	p.L16L	ALG13_uc004epi.1_Silent_p.L16L|ALG13_uc011msw.1_5'UTR|ALG13_uc011msx.1_5'UTR|ALG13_uc011msz.1_5'UTR|ALG13_uc011mta.1_5'UTR|ALG13_uc011mtb.1_5'UTR			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	16					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						TTGACGACCTCATTGCGTGTG	0.632													123	30					0	0	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795413	142795413	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chrX:142795413G>T	uc004fbz.2	-	2	1019	c.265C>A	c.(265-267)CTA>ATA	p.L89I		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	89										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GCTGAGTCTAGGCCTTCGTCC	0.488													252	73					9.62967e-114	1.60341e-113	1	0
AFF2	2334	broad.mit.edu	37	X	148072769	148072769	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chrX:148072769G>T	uc004fcp.2	+	21	4322	c.3843G>T	c.(3841-3843)ATG>ATT	p.M1281I	AFF2_uc004fcq.2_Missense_Mutation_p.M1271I|AFF2_uc004fcr.2_Missense_Mutation_p.M1242I|AFF2_uc011mxb.1_Missense_Mutation_p.M1246I|AFF2_uc004fcs.2_Missense_Mutation_p.M1246I|AFF2_uc011mxc.1_Missense_Mutation_p.M922I	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1281					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					ACACGCTGATGGGGCCTCTGA	0.493													62	18					2.02796e-37	3.2978e-37	1	0
TNR	7143	broad.mit.edu	37	1	175362961	175362962	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:175362961_175362962insA	uc001gkp.1	-	4	1391_1392	c.1310_1311insT	c.(1309-1311)CCCfs	p.P437fs	TNR_uc009wwu.1_Frame_Shift_Ins_p.P437fs|TNR_uc010pmz.1_3'UTR	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	437	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					AAAATGAGAAGGGCTCCCACTG	0.455													---	---	---							
CRB1	23418	broad.mit.edu	37	1	197390341	197390355	+	In_Frame_Del	DEL	AGATGGCCAGCATGG	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:197390341_197390355delAGATGGCCAGCATGG	uc001gtz.2	+	6	1518_1532	c.1383_1397delAGATGGCCAGCATGG	c.(1381-1398)CAAGATGGCCAGCATGGA>CAA	p.DGQHG462del	CRB1_uc010poz.1_In_Frame_Del_p.DGQHG393del|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_In_Frame_Del_p.DGQHG350del|CRB1_uc010ppb.1_In_Frame_Del_p.DGQHG462del|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_5'UTR|CRB1_uc001gub.1_In_Frame_Del_p.DGQHG111del	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	462_466	Extracellular (Potential).|EGF-like 11.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						CTCACTTCCAAGATGGCCAGCATGGATTCAGCTGC	0.484													---	---	---							
Unknown	0	broad.mit.edu	37	1	224052063	224052063	+	IGR	DEL	G	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr1:224052063delG								TP53BP2 (18389 upstream) : FBXO28 (249728 downstream)																							CCCCGTAGAAGGGCACAGTGT	0.622													---	---	---							
Unknown	0	broad.mit.edu	37	11	40105289	40105289	+	IGR	DEL	T	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr11:40105289delT								None (None upstream) : LRRC4C (30464 downstream)																							GGTATCTTTGTTTTGGATTTC	0.343													---	---	---							
FGF23	8074	broad.mit.edu	37	12	4479740	4479740	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr12:4479740delC	uc001qmq.1	-	3	671	c.525delG	c.(523-525)CGGfs	p.R175fs		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	175					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			GGGTGTGCCGCCGTGGTATGG	0.672													---	---	---							
ITPRIPL2	162073	broad.mit.edu	37	16	19127024	19127026	+	In_Frame_Del	DEL	TGC	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr16:19127024_19127026delTGC	uc002dfu.3	+	1	1771_1773	c.1241_1243delTGC	c.(1240-1245)GTGCTG>GTG	p.L416del	ITPRIPL2_uc002dft.2_In_Frame_Del_p.L112del	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	416	Cytoplasmic (Potential).					integral to membrane				skin(2)	2						CTGCTGGCAGTGCTGCTGCGCAA	0.655													---	---	---							
NANOS3	342977	broad.mit.edu	37	19	13988559	13988561	+	In_Frame_Del	DEL	GAG	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:13988559_13988561delGAG	uc002mxj.3	+	1	610_612	c.497_499delGAG	c.(496-501)CGAGGA>CGA	p.G171del		NM_001098622	NP_001092092	P60323	NANO3_HUMAN	nanos homolog 3	152					anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			GGCCACCGCCGAGGAGGAGGAGG	0.645													---	---	---							
HNRNPL	3191	broad.mit.edu	37	19	39330958	39330959	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr19:39330958_39330959insG	uc010xul.1	-	8	1021_1022	c.1010_1011insC	c.(1009-1011)CCAfs	p.P337fs	HNRNPL_uc010ege.1_5'UTR|HNRNPL_uc002ojj.1_5'UTR|HNRNPL_uc002ojo.1_5'Flank|HNRNPL_uc002ojk.2_5'UTR|HNRNPL_uc002ojl.2_5'UTR|HNRNPL_uc010xum.1_Frame_Shift_Ins_p.P204fs|HNRNPL_uc002ojp.1_5'UTR|HNRNPL_uc010xun.1_Frame_Shift_Ins_p.H45fs	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	337	Pro-rich.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			CGTAGTGAGGTGGGGGGGGCCC	0.668													---	---	---							
Unknown	0	broad.mit.edu	37	2	64603286	64603288	+	IGR	DEL	CAC	-	-	rs141929982		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:64603286_64603288delCAC								PELI1 (231681 upstream) : HSPC159 (78039 downstream)																							ccaccaccatcaccaccatcacc	0.000													---	---	---							
PTPRN	5798	broad.mit.edu	37	2	220164922	220164922	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr2:220164922delG	uc002vkz.2	-	9	1310	c.1221delC	c.(1219-1221)CCCfs	p.P407fs	PTPRN_uc010zlc.1_Frame_Shift_Del_p.P317fs|PTPRN_uc002vla.2_Frame_Shift_Del_p.P407fs	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	407	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GTCCAGGCATGGGGGATGTGC	0.632													---	---	---							
PIK3CA	5290	broad.mit.edu	37	3	178916938	178916940	+	In_Frame_Del	DEL	GAA	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr3:178916938_178916940delGAA	uc003fjk.2	+	2	482_484	c.325_327delGAA	c.(325-327)GAAdel	p.E110del		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	110					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E109del(2)|p.G106_R108del(1)|p.E110K(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGGCAACCGTGAAGAAAAGATCC	0.340		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---							
Unknown	0	broad.mit.edu	37	4	119428155	119428156	+	IGR	INS	-	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr4:119428155_119428156insT								PRSS12 (154233 upstream) : CEP170L (9339 downstream)																							AGCATAAAttcttttttttttt	0.183													---	---	---							
Unknown	0	broad.mit.edu	37	9	93513725	93513727	+	IGR	DEL	AAC	-	-	rs34140480		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:93513725_93513727delAAC								DIRAS2 (108617 upstream) : SYK (50285 downstream)																							AAAATAAGCAAACAACTGCCAGG	0.478													---	---	---							
SETX	23064	broad.mit.edu	37	9	135203353	135203376	+	In_Frame_Del	DEL	CGTGAATTGGGAGTTGAAGTCCTT	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chr9:135203353_135203376delCGTGAATTGGGAGTTGAAGTCCTT	uc004cbk.2	-	10	3792_3815	c.3609_3632delAAGGACTTCAACTCCCAATTCACG	c.(3607-3633)AGAAGGACTTCAACTCCCAATTCACGT>AGT	p.1203_1211RRTSTPNSR>S	SETX_uc004cbj.2_In_Frame_Del_p.822_830RRTSTPNSR>S|SETX_uc010mzt.2_In_Frame_Del_p.822_830RRTSTPNSR>S	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	1203_1211					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TCTCTGAATACGTGAATTGGGAGTTGAAGTCCTTCTATCAATAC	0.402													---	---	---							
Unknown	0	broad.mit.edu	37	Y	13500860	13500860	+	IGR	DEL	G	-	-	rs76607402		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrY:13500860delG								None (None upstream) : None (None downstream)																							TGATTTCTAAGACTTTTGAAA	0.274													---	---	---							
DAZ2	57055	broad.mit.edu	37	Y	25375814	25375815	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	509b9b7a-4866-4142-b194-be5c61237ac8	g.chrY:25375814_25375815delCA	uc004fvq.2	+	7	764_765	c.568_569delCA	c.(568-570)CAGfs	p.Q190fs	DAZ2_uc004fvr.2_Frame_Shift_Del_p.Q190fs|DAZ2_uc011nbl.1_Frame_Shift_Del_p.Q190fs|DAZ2_uc004fvv.2_Frame_Shift_Del_p.Q190fs|DAZ3_uc004fvw.2_Frame_Shift_Del_p.Q190fs|DAZ2_uc004fvt.2_Frame_Shift_Del_p.Q190fs|DAZ2_uc004fvu.2_Frame_Shift_Del_p.Q190fs|DAZ3_uc004fvs.2_Frame_Shift_Del_p.Q190fs|DAZ2_uc010nxl.1_Frame_Shift_Del_p.Q140fs|DAZ2_uc011nbk.1_Frame_Shift_Del_p.Q141fs|DAZ3_uc011nbm.1_Frame_Shift_Del_p.Q140fs	NM_020363	NP_065096	Q13117	DAZ2_HUMAN	deleted in azoospermia 2 isoform 1	190	DAZ-like 1.				cell differentiation|multicellular organismal development|single fertilization|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding				0						ATATAATTATCAGGTAATTGAA	0.356													---	---	---							
TNR	7143	broad.mit.edu	37	1	175362961	175362962	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:175362961_175362962insA	uc001gkp.1	-	4	1391_1392	c.1310_1311insT	c.(1309-1311)CCCfs	p.P437fs	TNR_uc009wwu.1_Frame_Shift_Ins_p.P437fs|TNR_uc010pmz.1_3'UTR	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	437	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					AAAATGAGAAGGGCTCCCACTG	0.455													---	---	---							
CRB1	23418	broad.mit.edu	37	1	197390341	197390355	+	In_Frame_Del	DEL	AGATGGCCAGCATGG	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:197390341_197390355delAGATGGCCAGCATGG	uc001gtz.2	+	6	1518_1532	c.1383_1397delAGATGGCCAGCATGG	c.(1381-1398)CAAGATGGCCAGCATGGA>CAA	p.DGQHG462del	CRB1_uc010poz.1_In_Frame_Del_p.DGQHG393del|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_In_Frame_Del_p.DGQHG350del|CRB1_uc010ppb.1_In_Frame_Del_p.DGQHG462del|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_5'UTR|CRB1_uc001gub.1_In_Frame_Del_p.DGQHG111del	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	462_466	Extracellular (Potential).|EGF-like 11.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						CTCACTTCCAAGATGGCCAGCATGGATTCAGCTGC	0.484													---	---	---							
Unknown	0	broad.mit.edu	37	1	224052063	224052063	+	IGR	DEL	G	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr1:224052063delG								TP53BP2 (18389 upstream) : FBXO28 (249728 downstream)																							CCCCGTAGAAGGGCACAGTGT	0.622													---	---	---							
Unknown	0	broad.mit.edu	37	10	42385340	42385362	+	IGR	DEL	GAATTATCTAATGCAATCGAATA	-	-	rs66510027		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr10:42385340_42385362delGAATTATCTAATGCAATCGAATA								None (None upstream) : LOC441666 (441953 downstream)																							gaatcgaagggaattatctaatgcaatcgaatagaattatcga	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	11	40105289	40105289	+	IGR	DEL	T	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr11:40105289delT								None (None upstream) : LRRC4C (30464 downstream)																							GGTATCTTTGTTTTGGATTTC	0.343													---	---	---							
FGF23	8074	broad.mit.edu	37	12	4479740	4479740	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr12:4479740delC	uc001qmq.1	-	3	671	c.525delG	c.(523-525)CGGfs	p.R175fs		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	175					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			GGGTGTGCCGCCGTGGTATGG	0.672													---	---	---							
Unknown	0	broad.mit.edu	37	12	68946695	68946696	+	IGR	INS	-	T	T			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr12:68946695_68946696insT								MDM1 (220534 upstream) : RAP1B (57956 downstream)																							tcaaattattcttttttTTTTT	0.178													---	---	---							
ITPRIPL2	162073	broad.mit.edu	37	16	19127024	19127026	+	In_Frame_Del	DEL	TGC	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr16:19127024_19127026delTGC	uc002dfu.3	+	1	1771_1773	c.1241_1243delTGC	c.(1240-1245)GTGCTG>GTG	p.L416del	ITPRIPL2_uc002dft.2_In_Frame_Del_p.L112del	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	416	Cytoplasmic (Potential).					integral to membrane				skin(2)	2						CTGCTGGCAGTGCTGCTGCGCAA	0.655													---	---	---							
NANOS3	342977	broad.mit.edu	37	19	13988559	13988561	+	In_Frame_Del	DEL	GAG	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:13988559_13988561delGAG	uc002mxj.3	+	1	610_612	c.497_499delGAG	c.(496-501)CGAGGA>CGA	p.G171del		NM_001098622	NP_001092092	P60323	NANO3_HUMAN	nanos homolog 3	152					anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			GGCCACCGCCGAGGAGGAGGAGG	0.645													---	---	---							
HNRNPL	3191	broad.mit.edu	37	19	39330958	39330959	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr19:39330958_39330959insG	uc010xul.1	-	8	1021_1022	c.1010_1011insC	c.(1009-1011)CCAfs	p.P337fs	HNRNPL_uc010ege.1_5'UTR|HNRNPL_uc002ojj.1_5'UTR|HNRNPL_uc002ojo.1_5'Flank|HNRNPL_uc002ojk.2_5'UTR|HNRNPL_uc002ojl.2_5'UTR|HNRNPL_uc010xum.1_Frame_Shift_Ins_p.P204fs|HNRNPL_uc002ojp.1_5'UTR|HNRNPL_uc010xun.1_Frame_Shift_Ins_p.H45fs	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	337	Pro-rich.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			CGTAGTGAGGTGGGGGGGGCCC	0.668													---	---	---							
PTPRN	5798	broad.mit.edu	37	2	220164922	220164922	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr2:220164922delG	uc002vkz.2	-	9	1310	c.1221delC	c.(1219-1221)CCCfs	p.P407fs	PTPRN_uc010zlc.1_Frame_Shift_Del_p.P317fs|PTPRN_uc002vla.2_Frame_Shift_Del_p.P407fs	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	407	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GTCCAGGCATGGGGGATGTGC	0.632													---	---	---							
PIK3CA	5290	broad.mit.edu	37	3	178916938	178916940	+	In_Frame_Del	DEL	GAA	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr3:178916938_178916940delGAA	uc003fjk.2	+	2	482_484	c.325_327delGAA	c.(325-327)GAAdel	p.E110del		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	110					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E109del(2)|p.G106_R108del(1)|p.E110K(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGGCAACCGTGAAGAAAAGATCC	0.340		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---							
SETX	23064	broad.mit.edu	37	9	135203353	135203376	+	In_Frame_Del	DEL	CGTGAATTGGGAGTTGAAGTCCTT	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chr9:135203353_135203376delCGTGAATTGGGAGTTGAAGTCCTT	uc004cbk.2	-	10	3792_3815	c.3609_3632delAAGGACTTCAACTCCCAATTCACG	c.(3607-3633)AGAAGGACTTCAACTCCCAATTCACGT>AGT	p.1203_1211RRTSTPNSR>S	SETX_uc004cbj.2_In_Frame_Del_p.822_830RRTSTPNSR>S|SETX_uc010mzt.2_In_Frame_Del_p.822_830RRTSTPNSR>S	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	1203_1211					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TCTCTGAATACGTGAATTGGGAGTTGAAGTCCTTCTATCAATAC	0.402													---	---	---							
Unknown	0	broad.mit.edu	37	Y	13500860	13500860	+	IGR	DEL	G	-	-	rs76607402		TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chrY:13500860delG								None (None upstream) : None (None downstream)																							TGATTTCTAAGACTTTTGAAA	0.274													---	---	---							
DAZ2	57055	broad.mit.edu	37	Y	25375814	25375815	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-CV-6935-01A-11D-1912-08	TCGA-CV-6935-11A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc0ebce-5ba2-4c18-b594-50b33ef6d116	2f8440cd-a99d-4f7c-9d8f-e87fe3c34c01	g.chrY:25375814_25375815delCA	uc004fvq.2	+	7	764_765	c.568_569delCA	c.(568-570)CAGfs	p.Q190fs	DAZ2_uc004fvr.2_Frame_Shift_Del_p.Q190fs|DAZ2_uc011nbl.1_Frame_Shift_Del_p.Q190fs|DAZ2_uc004fvv.2_Frame_Shift_Del_p.Q190fs|DAZ3_uc004fvw.2_Frame_Shift_Del_p.Q190fs|DAZ2_uc004fvt.2_Frame_Shift_Del_p.Q190fs|DAZ2_uc004fvu.2_Frame_Shift_Del_p.Q190fs|DAZ3_uc004fvs.2_Frame_Shift_Del_p.Q190fs|DAZ2_uc010nxl.1_Frame_Shift_Del_p.Q140fs|DAZ2_uc011nbk.1_Frame_Shift_Del_p.Q141fs|DAZ3_uc011nbm.1_Frame_Shift_Del_p.Q140fs	NM_020363	NP_065096	Q13117	DAZ2_HUMAN	deleted in azoospermia 2 isoform 1	190	DAZ-like 1.				cell differentiation|multicellular organismal development|single fertilization|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding				0						ATATAATTATCAGGTAATTGAA	0.356													---	---	---							
