Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-114H24.7	0	broad.mit.edu	37	15	78211517	78211517	+	RNA	SNP	C	C	G			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr15:78211517C>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TTGCTCAGGACACTCAAGGCC	0.557000													4	161					0	0	1	0	0
KIF12	113220	broad.mit.edu	37	9	116858369	116858369	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr9:116858369A>G	ENST00000374118.3	-	6	680	c.443T>C	c.(442-444)cTt>cCt	p.L148P	KIF12_ENST00000473174.1_Intron	NM_138424.1	NP_612433.1	Q96FN5	KIF12_HUMAN	kinesin family member 12	281	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	17						GTTAGCCTCAAGCATCAGCTC	0.627000													6	116					0	0	1	0	0
C9orf3	84909	broad.mit.edu	37	9	97843033	97843033	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr9:97843033A>G	ENST00000375315.2	+	14	2290	c.2290A>G	c.(2290-2292)Agt>Ggt	p.S764G	C9orf3_ENST00000433691.2_Missense_Mutation_p.S105G|C9orf3_ENST00000425634.2_Missense_Mutation_p.S126G|C9orf3_ENST00000297979.5_Missense_Mutation_p.S665G	NM_001193329.1	NP_001180258.1	Q8N6M6	AMPO_HUMAN	chromosome 9 open reading frame 3	764					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		AGCCTACAAAAGTGTGGAGAG	0.512000													24	65					0	0	1	0	0
ELK3	2004	broad.mit.edu	37	12	96641092	96641092	+	Silent	SNP	C	C	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr12:96641092C>T	ENST00000228741.3	+	3	908	c.582C>T	c.(580-582)gtC>gtT	p.V194V	ELK3_ENST00000552142.1_Intron	NM_005230.2	NP_005221.2	P41970	ELK3_HUMAN	ELK3, ETS-domain protein (SRF accessory protein 2)	194					negative regulation of transcription, DNA-dependent|signal transduction	mitochondrion	protein binding|purine-rich negative regulatory element binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(5)|ovary(2)|prostate(1)|stomach(2)	20	all_cancers(2;0.00173)					ACAAGCACGTCACCAGGCCGG	0.607000													7	76					0	0	1	0	0
GLRA1	2741	broad.mit.edu	37	5	151239422	151239422	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr5:151239422C>T	ENST00000274576.4	-	4	692	c.400G>A	c.(400-402)Gcc>Acc	p.A134T	GLRA1_ENST00000471351.2_5'UTR|GLRA1_ENST00000455880.2_Missense_Mutation_p.A134T|GLRA1_ENST00000545569.1_Missense_Mutation_p.A51T	NM_000171.3|NM_001146040.1	NP_000162.2|NP_001139512.1	P23415	GLRA1_HUMAN	glycine receptor, alpha 1	134					muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	23		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TGGAAGTGGGCCCCCTTCTCG	0.522000													25	64					0	0	1	0	0
SLC4A2	6522	broad.mit.edu	37	7	150761318	150761318	+	Silent	SNP	G	G	A	rs142515597	byFrequency	TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr7:150761318G>A	ENST00000485713.1	+	3	1121	c.81G>A	c.(79-81)acG>acA	p.T27T	SLC4A2_ENST00000392826.2_Silent_p.T18T|SLC4A2_ENST00000461735.1_Silent_p.T13T|SLC4A2_ENST00000310317.5_Intron|SLC4A2_ENST00000413384.2_Silent_p.T27T	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	27	Pro-rich.				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCCCTGGGACGCCTGGGTTCC	0.622000													20	58					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18745235	18745235	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr2:18745235G>A	ENST00000304081.4	-	9	1580	c.1480C>T	c.(1480-1482)Cgc>Tgc	p.R494C	NT5C1B_ENST00000359846.2_Missense_Mutation_p.R554C|NT5C1B_ENST00000600945.1_Missense_Mutation_p.R554C|NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.R554C	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				AGACCCCAGCGTCGAAGGGTC	0.522000													16	63					0	0	1	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12836145	12836145	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr1:12836145C>G	ENST00000357726.4	+	2	774	c.747C>G	c.(745-747)gaC>gaG	p.D249E		NM_001080830.1	NP_001074299.1	O95522	PRA12_HUMAN	PRAME family member 12	249										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|urinary_tract(1)	23	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTCCCCTAGACAGGAAGGAGC	0.498000													22	105					0	0	1	0	0
USP3	9960	broad.mit.edu	37	15	63852135	63852135	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr15:63852135A>G	ENST00000268049.7	+	8	871	c.547A>G	c.(547-549)Aca>Gca	p.T183A	USP3_ENST00000536001.1_Intron|USP3_ENST00000539772.1_Intron|USP3_ENST00000540797.1_Missense_Mutation_p.T161A|USP3-AS1_ENST00000560350.1_RNA|USP3-AS1_ENST00000559357.1_RNA|USP3-AS1_ENST00000559861.1_RNA|USP3_ENST00000559711.1_Missense_Mutation_p.T116A|USP3_ENST00000558285.1_Missense_Mutation_p.T188A|USP3_ENST00000380324.3_Missense_Mutation_p.T205A			Q9Y6I4	UBP3_HUMAN	ubiquitin specific peptidase 3	205					DNA repair|histone deubiquitination|mitotic cell cycle|regulation of protein stability|ubiquitin-dependent protein catabolic process	nuclear chromatin	histone binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			endometrium(3)|large_intestine(7)|lung(4)	14				GBM - Glioblastoma multiforme(80;0.0187)		AGGAAGGCGGACATACCACAC	0.413000													5	22					0	0	1	0	0
ZNF101	94039	broad.mit.edu	37	19	19790542	19790542	+	Silent	SNP	T	T	C			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr19:19790542T>C	ENST00000592502.1	+	4	854	c.744T>C	c.(742-744)acT>acC	p.T248T	ZNF101_ENST00000415784.2_Silent_p.T128T|ZNF101_ENST00000444249.2_3'UTR			Q8IZC7	ZN101_HUMAN	zinc finger protein 101	248					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)	17						GAACTCACACTGGAGAAAAAC	0.383000													6	23					0	0	1	0	0
CAT	847	broad.mit.edu	37	11	34474685	34474685	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr11:34474685A>G	ENST00000241052.4	+	5	618	c.529A>G	c.(529-531)Aag>Gag	p.K177E		NM_001752.3	NP_001743.1	P04040	CATA_HUMAN	catalase	177					hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			breast(1)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|stomach(1)|urinary_tract(3)	26		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)	gacacatctgaaggatccgga	0.398000													7	23					0	0	1	0	0
ZNF326	284695	broad.mit.edu	37	1	90473286	90473286	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr1:90473286A>G	ENST00000370447.3	+	5	446	c.325A>G	c.(325-327)Aca>Gca	p.T109A	ZNF326_ENST00000340281.4_Missense_Mutation_p.T198A|ZNF326_ENST00000455342.2_Intron			Q5BKZ1	ZN326_HUMAN	zinc finger protein 326		Gly-rich.|Mediates transcriptional activation (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(7)|ovary(1)	25		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		AGGACCATCAACAGGCAGAGG	0.463000													7	51					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99725896	99725896	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr2:99725896G>A	ENST00000393483.3	-	6	851	c.7C>T	c.(7-9)Cga>Tga	p.R3*	TSGA10_ENST00000478090.1_5'UTR|TSGA10_ENST00000539964.1_Nonsense_Mutation_p.R3*|TSGA10_ENST00000355053.4_Nonsense_Mutation_p.R3*|TSGA10_ENST00000410001.1_Nonsense_Mutation_p.R3*|TSGA10_ENST00000542655.1_Nonsense_Mutation_p.R3*	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	3					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						GACCTACTTCGCATCATCTTT	0.393000													9	52					0	0	1	0	0
PDXDC2P	0	broad.mit.edu	37	16	70010646	70010646	+	RNA	SNP	G	G	A	rs149870591	by1000genomes	TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr16:70010646G>A	ENST00000531894.1	-	0	3748					NR_003610.1																						CTGTAGGGCCGAAGAAGGGAA	0.478000													4	65					0	0	1	0	0
SYTL1	84958	broad.mit.edu	37	1	27674032	27674032	+	Silent	SNP	G	G	A			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr1:27674032G>A	ENST00000543823.1	+	2	774	c.312G>A	c.(310-312)gcG>gcA	p.A104A	SYTL1_ENST00000318074.5_Silent_p.A104A			Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	104					exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			NS(1)|large_intestine(4)|lung(5)|ovary(1)|urinary_tract(1)	12		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TTGTCCGAGCGTCTATGCGCA	0.632000													19	53					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60448832	60448832	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr20:60448832C>T	ENST00000360469.5	+	7	1014	c.926C>T	c.(925-927)aCg>aTg	p.T309M	CDH4_ENST00000543233.1_Missense_Mutation_p.T235M	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	309	Cadherin 2.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GACAGCACCACGGCCAACGGG	0.602000													26	73					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102482730	102482730	+	Silent	SNP	C	C	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr14:102482730C>T	ENST00000360184.4	+	37	7682	c.7518C>T	c.(7516-7518)agC>agT	p.S2506S		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2506					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CTGGAGACAGCCGGCTAAAAA	0.418000													4	56					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43906957	43906957	+	Missense_Mutation	SNP	A	A	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr1:43906957A>T	ENST00000562955.1	+	52	7246	c.7246A>T	c.(7246-7248)Act>Tct	p.T2416S	SZT2_ENST00000372442.1_Missense_Mutation_p.T1574S	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2473						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GCCAGAAGACACTCGGGGCCG	0.552000													39	131					0	0	1	0	0
FAM183B	340286	broad.mit.edu	37	7	38725370	38725370	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr7:38725370G>A	ENST00000409072.3	-	2	1170	c.236C>T	c.(235-237)aCg>aTg	p.T79M						family with sequence similarity 183, member B											endometrium(1)|lung(7)	8						GTACTTCTTCGTTGGCCCCTG	0.547000													42	115					0	0	1	0	0
ANAPC5	51433	broad.mit.edu	37	12	121766164	121766164	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr12:121766164A>G	ENST00000261819.3	-	10	1380	c.1259T>C	c.(1258-1260)aTc>aCc	p.I420T	ANAPC5_ENST00000541887.1_Missense_Mutation_p.I407T|ANAPC5_ENST00000344395.4_Missense_Mutation_p.I308T|ANAPC5_ENST00000441917.2_Missense_Mutation_p.I308T|ANAPC5_ENST00000535482.1_Missense_Mutation_p.I86T|ANAPC5_ENST00000544314.1_5'UTR	NM_016237.4	NP_057321.2	Q9UJX4	APC5_HUMAN	anaphase promoting complex subunit 5	420					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			breast(6)|endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|prostate(1)|skin(3)	31	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TGCGATGCTGATATCGATGAG	0.547000													11	36					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427759	3427759	+	RNA	SNP	C	C	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr11:3427759C>T	ENST00000529482.1	+	0	876																											TGTCTGCACACGTCCTGCAGT	0.612000													4	46					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31372440	31372440	+	Silent	SNP	G	G	A			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr16:31372440G>A	ENST00000268296.4	+	9	1039	c.918G>A	c.(916-918)tcG>tcA	p.S306S	ITGAX_ENST00000562522.1_Silent_p.S306S	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	306	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						ACATTGCATCGAAGCCCTCCC	0.363000													30	104					0	0	1	0	0
NELFB	25920	broad.mit.edu	37	9	140161398	140161398	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr9:140161398G>C	ENST00000343053.4	+	9	1435	c.1098G>C	c.(1096-1098)gaG>gaC	p.E366D		NM_015456.3	NP_056271.2			negative elongation factor complex member B																		CCTCGTAGGAGGTAGAGCTCA	0.642000													8	35					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20828569	20828569	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr19:20828569C>A	ENST00000601440.1	-	3	293	c.147G>T	c.(145-147)aaG>aaT	p.K49N	CTC-513N18.7_ENST00000595094.1_lincRNA|ZNF626_ENST00000291750.6_Missense_Mutation_p.K49N	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	49	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						TCAGGTCTGGCTTAGAAACAG	0.378000													10	37					1.5842e-08	1.60935e-08	1	1	0
P2RX5-TAX1BP3	0	broad.mit.edu	37	17	3593952	3593952	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr17:3593952G>A	ENST00000550383.1	-	4	571	c.383C>T	c.(382-384)gCg>gTg	p.A128V	P2RX5_ENST00000225328.5_Missense_Mutation_p.A128V|P2RX5_ENST00000552050.1_Missense_Mutation_p.A68V|P2RX5_ENST00000345901.3_Missense_Mutation_p.A104V|P2RX5_ENST00000547178.1_Missense_Mutation_p.A128V|P2RX5_ENST00000552276.1_Missense_Mutation_p.A128V|P2RX5_ENST00000435558.1_Missense_Mutation_p.A128V|P2RX5_ENST00000551178.1_Missense_Mutation_p.A104V																							CTTGGAGCACGCGCCATCAGG	0.637000													14	39					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108863658	108863658	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr2:108863658A>G	ENST00000376700.1	+	1	8	c.8A>G	c.(7-9)aAg>aGg	p.K3R	SULT1C3_ENST00000329106.2_Missense_Mutation_p.K3R			Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	3						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						CCAATGGCGAAGATTGAGAAA	0.358000													13	63					0	0	1	0	0
SWI5	375757	broad.mit.edu	37	9	131038453	131038453	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr9:131038453G>A	ENST00000320188.5	+	1	29	c.29G>A	c.(28-30)tGg>tAg	p.W10*	SWI5_ENST00000495313.1_Intron	NM_001040011.1	NP_001035100.1	Q1ZZU3	SWI5_HUMAN	SWI5 recombination repair homolog (yeast)						double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding	p.W10L(1)									AGGGACCTGTGGCGTCACAAC	0.642000													25	100					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167655091	167655091	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr5:167655091G>C	ENST00000519204.1	+	24	5231	c.5113G>C	c.(5113-5115)Gaa>Caa	p.E1705Q	TENM2_ENST00000518659.1_Missense_Mutation_p.E1826Q|TENM2_ENST00000520394.1_Missense_Mutation_p.E1587Q|TENM2_ENST00000403607.2_Missense_Mutation_p.E1650Q|TENM2_ENST00000545108.1_Missense_Mutation_p.E1825Q					teneurin transmembrane protein 2																		CCTAAGAAAGGAACAGATTAA	0.517000													3	21					0	0	1	0	0
RAB4B-EGLN2	0	broad.mit.edu	37	19	41289852	41289852	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr19:41289852C>T	ENST00000594136.1	+	5	407	c.302C>T	c.(301-303)gCc>gTc	p.A101V	RAB4B_ENST00000357052.2_Missense_Mutation_p.A101V|RAB4B-EGLN2_ENST00000601949.1_Intron|RAB4B_ENST00000602069.1_3'UTR|RAB4B_ENST00000594800.1_Missense_Mutation_p.A101V|MIA-RAB4B_ENST00000600729.1_3'UTR																							TCACTGGCTGCCTGGCTGACG	0.642000													15	36					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	G	C			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr11:3427765G>C	ENST00000529482.1	+	0	882																											CACACGTCCTGCAGTGGCCTG	0.602000													4	46					0	0	1	0	0
GCC2	9648	broad.mit.edu	37	2	109086210	109086210	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr2:109086210G>T	ENST00000309863.6	+	6	1139	c.425G>T	c.(424-426)cGt>cTt	p.R142L	GCC2_ENST00000485546.1_3'UTR	NM_181453.3	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	142					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						ATGGCAGTACGTTCCAAATAC	0.338000													22	52					4.35082e-09	4.49117e-09	1	1	0
ILVBL	10994	broad.mit.edu	37	19	15234004	15234004	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr19:15234004C>A	ENST00000263383.3	-	4	527	c.388G>T	c.(388-390)Gtg>Ttg	p.V130L	ILVBL_ENST00000534378.1_Missense_Mutation_p.V23L|ILVBL_ENST00000531635.1_5'UTR	NM_006844.3	NP_006835.2	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	130						integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			NS(3)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)	26						ACCGCAGTCACCGTGTTGGTG	0.627000													25	103					7.38237e-10	7.87453e-10	1	1	0
TJAP1	93643	broad.mit.edu	37	6	43473228	43473228	+	Missense_Mutation	SNP	G	G	A	rs142853495		TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr6:43473228G>A	ENST00000372444.2	+	11	1712	c.1279G>A	c.(1279-1281)Gat>Aat	p.D427N	TJAP1_ENST00000259751.1_Missense_Mutation_p.D427N|TJAP1_ENST00000438588.2_Missense_Mutation_p.D437N|TJAP1_ENST00000372452.1_Missense_Mutation_p.D427N|TJAP1_ENST00000372445.5_Missense_Mutation_p.D437N|TJAP1_ENST00000483640.1_3'UTR|TJAP1_ENST00000372449.1_Missense_Mutation_p.D437N|TJAP1_ENST00000436109.2_Missense_Mutation_p.D427N	NM_001146018.1	NP_001139490.1	Q5JTD0	TJAP1_HUMAN	tight junction associated protein 1 (peripheral)	437						Golgi apparatus|tight junction	protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|urinary_tract(2)	21	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0122)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CTTTGGACGCGATGCCCTCCC	0.622000													18	58					0	0	1	0	0
PBXIP1	57326	broad.mit.edu	37	1	154924328	154924328	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr1:154924328G>A	ENST00000368463.3	-	3	192	c.121C>T	c.(121-123)Cct>Tct	p.P41S	PBXIP1_ENST00000368460.3_Missense_Mutation_p.P41S|PBXIP1_ENST00000368465.1_Missense_Mutation_p.P12S|PBXIP1_ENST00000542459.1_Intron|PBXIP1_ENST00000498553.1_Intron|PBXIP1_ENST00000539880.1_Intron	NM_020524.2	NP_065385.2	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein 1	41					cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			breast(1)|kidney(2)|large_intestine(6)|lung(13)|prostate(1)|urinary_tract(1)	24	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGGCTGTGAGGGGCCTGCAGG	0.582000													39	190					0	0	1	0	0
SKIDA1	387640	broad.mit.edu	37	10	21805058	21805058	+	Missense_Mutation	SNP	T	T	A			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr10:21805058T>A	ENST00000449193.2	-	4	3946	c.1694A>T	c.(1693-1695)aAg>aTg	p.K565M	SKIDA1_ENST00000444772.3_Missense_Mutation_p.K486M	NM_207371.3	NP_997254.3			SKI/DACH domain containing 1																		GTCAGTTCTCTTTACAGCATT	0.483000													20	65					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40374061	40374061	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr19:40374061T>C	ENST00000221347.6	-	26	12024	c.12017A>G	c.(12016-12018)aAc>aGc	p.N4006S		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4006	Cys-rich.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CTGCCGACAGTTGTCAATGAG	0.632000													4	11					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156641138	156641138	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr1:156641138C>T	ENST00000368223.3	-	4	2974	c.2842G>A	c.(2842-2844)Gtg>Atg	p.V948M		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	948	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CACCTCTGCACATCTGCAGAC	0.552000													5	247					0	0	1	0	0
SPOPL	339745	broad.mit.edu	37	2	139318404	139318404	+	Silent	SNP	T	T	C			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr2:139318404T>C	ENST00000280098.4	+	8	1123	c.744T>C	c.(742-744)ccT>ccC	p.P248P		NM_001001664.2	NP_001001664.1	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	248	BTB.					nucleus				breast(2)|cervix(2)|endometrium(2)|large_intestine(2)|lung(11)|skin(2)	21				BRCA - Breast invasive adenocarcinoma(221;0.0296)		ATTTAGACCCTGAAGTTTTTA	0.333000													3	52					0	0	1	0	0
HRCT1	646962	broad.mit.edu	37	9	35906559	35906559	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr9:35906559A>C	ENST00000354323.2	+	1	371	c.275A>C	c.(274-276)cAc>cCc	p.H92P		NM_001039792.1	NP_001034881.1	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	92	His-rich.					integral to membrane		p.H92P(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						caccaccaccacccccgccac	0.682000													11	19					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45695922	45695922	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr5:45695922C>T	ENST00000303230.4	-	1	331	c.274G>A	c.(274-276)Ggc>Agc	p.G92S		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	92	Involved in subunit assembly (By similarity).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TGCATGAAGCCGTACTGCCGC	0.697000													7	28					0	0	1	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104999297	104999297	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chrX:104999297G>T	ENST00000372582.1	+	10	2075	c.1319G>T	c.(1318-1320)gGa>gTa	p.G440V	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.G440V|IL1RAPL2_ENST00000485671.1_3'UTR	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	440	TIR.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AAACACTATGGATATAAACTC	0.368000													33	40					1.36161e-19	1.47701e-19	1	1	0
LRIF1	55791	broad.mit.edu	37	1	111494344	111494344	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr1:111494344C>T	ENST00000369763.4	-	2	1552	c.1162G>A	c.(1162-1164)Gat>Aat	p.D388N	RP11-96K19.2_ENST00000440689.1_RNA|LRIF1_ENST00000494675.1_Intron|LRIF1_ENST00000485275.2_Intron	NM_018372.3	NP_060842.3	Q5T3J3	LRIF1_HUMAN	ligand dependent nuclear receptor interacting factor 1	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(1)|urinary_tract(2)	28						ACTGGAGTATCAGGAGAAACA	0.373000													44	158					0	0	1	0	0
PDPK1	5170	broad.mit.edu	37	16	2636776	2636776	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr16:2636776G>A	ENST00000342085.4	+	11	1374	c.1225G>A	c.(1225-1227)Ggc>Agc	p.G409S	PDPK1_ENST00000268673.7_Missense_Mutation_p.G282S|PDPK1_ENST00000389224.3_Missense_Mutation_p.G382S|PDPK1_ENST00000441549.3_Missense_Mutation_p.G409S|PDPK1_ENST00000354836.5_Missense_Mutation_p.G385S	NM_002613.4	NP_002604.1	O15530	PDPK1_HUMAN	3-phosphoinositide dependent protein kinase-1	409					actin cytoskeleton organization|activation of protein kinase B activity|insulin receptor signaling pathway|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|peptidyl-threonine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|synaptic transmission|T cell costimulation|T cell receptor signaling pathway	cytosol|nucleoplasm|plasma membrane	3-phosphoinositide-dependent protein kinase activity|ATP binding			central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)	7		Ovarian(90;0.17)			Celecoxib(DB00482)	CCAGAGGTCAGGCAGCAACAT	0.527000													36	111					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274424	39274424	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr17:39274424G>C	ENST00000391413.2	-	1	182	c.144C>G	c.(142-144)agC>agG	p.S48R		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	48	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament		p.S48R(2)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCCTGCAGCAGCTGGACACAC	0.672000													5	71					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31802972	31802972	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr18:31802972G>T	ENST00000261592.5	-	1	543	c.246C>A	c.(244-246)taC>taA	p.Y82*	RP11-379L18.1_ENST00000587528.1_RNA|NOL4_ENST00000589544.1_Nonsense_Mutation_p.Y82*|NOL4_ENST00000269185.4_5'UTR	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	82						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						TGACAGGCACGTAGAGCACTT	0.627000													9	38					7.48243e-07	7.48243e-07	1	1	0
ZFAT	57623	broad.mit.edu	37	8	135612780	135612780	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr8:135612780T>G	ENST00000520727.1	-	8	2637	c.2338A>C	c.(2338-2340)Aaa>Caa	p.K780Q	ZFAT_ENST00000429442.2_Missense_Mutation_p.K780Q|ZFAT-AS1_ENST00000505776.1_RNA|ZFAT_ENST00000520214.1_Missense_Mutation_p.K780Q|ZFAT_ENST00000520356.1_Missense_Mutation_p.K780Q|ZFAT_ENST00000523399.1_Missense_Mutation_p.K730Q|ZFAT_ENST00000377838.3_Missense_Mutation_p.K792Q	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	792					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TTACTGTGTTTCTGAATTACG	0.438000													31	109					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40066135	40066135	+	Silent	SNP	C	C	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr22:40066135C>T	ENST00000336649.4	+	28	4305	c.4305C>T	c.(4303-4305)gtC>gtT	p.V1435V	CACNA1I_ENST00000400164.3_Silent_p.V1394V|CACNA1I_ENST00000402142.3_Silent_p.V1429V|CACNA1I_ENST00000407673.1_Silent_p.V1394V|CACNA1I_ENST00000404898.1_Silent_p.V1394V|CACNA1I_ENST00000401624.1_Silent_p.V1429V			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1429					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TTGTGGGTGTCGTGGTGGAGA	0.602000													4	265					0	0	1	0	0
TOX3	27324	broad.mit.edu	37	16	52484190	52484190	+	Splice_Site	SNP	C	C	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr16:52484190C>T	ENST00000219746.9	-	4	961	c.677G>A	c.(676-678)aGa>aAa	p.R226K	TOX3_ENST00000407228.3_Splice_Site_p.R221K	NM_001080430.2	NP_001073899.2	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	226					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity			NS(2)|endometrium(6)|kidney(1)|lung(8)|prostate(3)|stomach(3)|upper_aerodigestive_tract(1)	24						CTAACTTACTCTGTTGGCTTC	0.463000													13	41					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152279919	152279919	+	Silent	SNP	C	C	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr1:152279919C>T	ENST00000368799.1	-	3	7478	c.7443G>A	c.(7441-7443)ttG>ttA	p.L2481L	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2481	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATCTATCTACCAATTGCTCGT	0.567000									Ichthyosis				8	523					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70064192	70064192	+	Missense_Mutation	SNP	C	C	T	rs142863825		TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr6:70064192C>T	ENST00000370598.1	+	27	4348	c.3527C>T	c.(3526-3528)tCg>tTg	p.S1176L	BAI3_ENST00000546190.1_Missense_Mutation_p.S140L|BAI3_ENST00000238918.8_Missense_Mutation_p.S382L	NM_001704.2	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1176	Poly-Ser.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				TCTTCGAGTTCGTTTCCTAAT	0.393000													23	77					0	0	1	0	0
FUT2	2524	broad.mit.edu	37	19	49206416	49206416	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr19:49206416C>T	ENST00000425340.2	+	2	320	c.203C>T	c.(202-204)gCa>gTa	p.A68V	FUT2_ENST00000391876.4_Missense_Mutation_p.A68V	NM_000511.5|NM_001097638.2	NP_000502.4|NP_001091107.1	Q10981	FUT2_HUMAN	fucosyltransferase 2 (secretor status included)	68					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)	7		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		ACGATCAATGCAATAGGCCGC	0.607000													9	43					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55591182	55591182	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr10:55591182C>A	ENST00000373965.2	-	31	4510	c.4116G>T	c.(4114-4116)aaG>aaT	p.K1372N	PCDH15_ENST00000361849.3_Missense_Mutation_p.K1365N|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.K1328N|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000414778.1_Missense_Mutation_p.K1370N|PCDH15_ENST00000395430.1_Missense_Mutation_p.K1365N|PCDH15_ENST00000437009.1_Missense_Mutation_p.K1294N|PCDH15_ENST00000395433.1_Missense_Mutation_p.K1343N|PCDH15_ENST00000409834.1_Missense_Mutation_p.K976N|PCDH15_ENST00000320301.6_Missense_Mutation_p.K1365N|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395445.1_Missense_Mutation_p.K1372N|PCDH15_ENST00000395438.1_Missense_Mutation_p.K1365N	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1365					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TTTCTCCTCTCTTTTTAATGC	0.483000										HNSCC(58;0.16)			12	51					2.80697e-09	2.94502e-09	1	1	0
NUP133	55746	broad.mit.edu	37	1	229577702	229577702	+	Silent	SNP	G	G	A			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr1:229577702G>A	ENST00000261396.3	-	26	3511	c.3420C>T	c.(3418-3420)ttC>ttT	p.F1140F	NUP133_ENST00000537506.1_Silent_p.F1124F	NM_018230.2	NP_060700.2	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	1140					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|breast(7)|endometrium(1)|kidney(6)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(4)	56	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				AAACAAACTCGAAGTAAGGAT	0.363000													24	68					0	0	1	0	0
TTC1	7265	broad.mit.edu	37	5	159476556	159476556	+	Silent	SNP	T	T	C			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr5:159476556T>C	ENST00000231238.5	+	6	687	c.577T>C	c.(577-579)Ttg>Ctg	p.L193L	TTC1_ENST00000522793.1_Silent_p.L193L|TTC1_ENST00000520274.1_3'UTR	NM_001282500.1|NM_003314.1	NP_001269429.1|NP_003305.1	Q99614	TTC1_HUMAN	tetratricopeptide repeat domain 1	193					protein folding		unfolded protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(1)|prostate(1)|skin(1)	12	Renal(175;0.00196)	all_hematologic(541;0.00014)|Breast(839;0.0101)|all_neural(177;0.0281)|Medulloblastoma(196;0.0425)|Lung NSC(249;0.119)|all_lung(500;0.163)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	Epithelial(171;8.37e-05)|all cancers(165;0.000694)|OV - Ovarian serous cystadenocarcinoma(192;0.0402)		CAGGGCAATATTGAGGAGAGC	0.348000													12	30					0	0	1	0	0
RPL37	6167	broad.mit.edu	37	5	40834355	40834355	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr5:40834355G>C	ENST00000274242.5	-	3	301	c.152C>G	c.(151-153)gCc>gGc	p.A51G	RPL37_ENST00000508493.1_Missense_Mutation_p.A51G|RPL37_ENST00000504562.1_5'UTR|RPL37_ENST00000509877.1_Intron	NM_000997.4	NP_000988.1	P61927	RL37_HUMAN	ribosomal protein L37	51					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	metal ion binding|protein binding|rRNA binding|structural constituent of ribosome			lung(3)|ovary(1)	4		Breast(839;0.238)				TTTAGCCTTGGCACTCCAGTT	0.408000													15	57					0	0	1	0	0
USHBP1	83878	broad.mit.edu	37	19	17370705	17370705	+	Splice_Site	SNP	C	C	T			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr19:17370705C>T	ENST00000252597.3	-	5	942		c.e5+1		USHBP1_ENST00000431146.2_Splice_Site	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1								PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						CTCGCACTCACCTGAGTCTCC	0.542000													11	49					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81671195	81671195	+	Frame_Shift_Del	DEL	T	T	-			TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr12:81671195delT	ENST00000333447.7	-	26	3174	c.3175delA	c.(3175-3177)agafs	p.R1059fs	PPFIA2_ENST00000548586.1_Splice_Site|PPFIA2_ENST00000552948.1_Splice_Site|PPFIA2_ENST00000549396.1_Splice_Site|PPFIA2_ENST00000549325.1_Splice_Site|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000443686.3_Splice_Site|PPFIA2_ENST00000541017.1_Splice_Site|PPFIA2_ENST00000550584.2_Splice_Site|PPFIA2_ENST00000407050.4_Splice_Site|RP11-121G22.3_ENST00000549161.1_lincRNA|PPFIA2_ENST00000541570.2_Splice_Site|PPFIA2_ENST00000550359.2_Splice_Site			B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	970										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						AAACTTGTTCtttttttttta	0.333													2	4	---	---	---	---					
PNMAL2	57469	broad.mit.edu	37	19	46997016	46997017	+	In_Frame_Ins	INS	-	-	CGGCCT	rs147338403	by1000genomes	TCGA-G9-6339-01A-12D-A30X-08	TCGA-G9-6339-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6e297e93-6cfe-43b1-aeb2-1151c6fe2a8a	23a6d650-d249-4674-a652-4669df3e3d64	g.chr19:46997016_46997017insCGGCCT	ENST00000599531.1	-	1	2738_2739	c.1706_1707insAGGCCG	c.(1705-1707)cgg>cgAGGCCGg	p.569_569R>RGR	PNMAL2_ENST00000594749.1_Intron|PNMAL2_ENST00000377655.2_Intron	NM_020709.1	NP_065760.1	Q9ULN7	PNML2_HUMAN	paraneoplastic Ma antigen family-like 2	571										central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(4)	8		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		GAGTGACGCCCCGGCCTCGGCC	0.777													2	4	---	---	---	---					
