Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CDK5R2	8941	broad.mit.edu	37	2	219825271	219825271	+	Silent	SNP	C	C	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr2:219825271C>T	ENST00000302625.4	+	1	895	c.729C>T	c.(727-729)tgC>tgT	p.C243C	AC097468.7_ENST00000429343.1_RNA	NM_003936.4	NP_003927.1	Q13319	CD5R2_HUMAN	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	243					regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase 5 holoenzyme complex	cyclin-dependent protein kinase 5 activator activity			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	8		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACCTGCTGTGCCGCGAGTCGC	0.662000													5	227					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63477082	63477082	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr18:63477082A>G	ENST00000536984.2	+	3	1047	c.353A>G	c.(352-354)tAc>tGc	p.Y118C	CDH7_ENST00000323011.3_Missense_Mutation_p.Y118C|CDH7_ENST00000397968.2_Missense_Mutation_p.Y118C			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	118	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				CAGGCCTACTACACGCTCCGA	0.502000													3	73					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625947	29625947	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr20:29625947T>C	ENST00000278882.3	+	5	571	c.191T>C	c.(190-192)aTt>aCt	p.I64T	FRG1B_ENST00000358464.4_Missense_Mutation_p.I64T|FRG1B_ENST00000439954.2_Missense_Mutation_p.I69T														p.I64T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TCAGATGCAATTGGACCAAGA	0.343000													5	104					0	0	1	0	0
GOT2	2806	broad.mit.edu	37	16	58743428	58743428	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr16:58743428G>A	ENST00000245206.5	-	9	1191	c.1063C>T	c.(1063-1065)Cgg>Tgg	p.R355W	GOT2_ENST00000434819.2_Missense_Mutation_p.R312W	NM_002080.2	NP_002071.2	P00505	AATM_HUMAN	glutamic-oxaloacetic transaminase 2, mitochondrial	355					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding	p.R355W(2)|p.R355G(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|prostate(2)|skin(1)	22					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AGTTGAGTCCGCATGCCAATG	0.507000													5	324					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228466419	228466419	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr1:228466419C>T	ENST00000570156.2	+	31	8250	c.8176C>T	c.(8176-8178)Cgg>Tgg	p.R2726W	OBSCN_ENST00000359599.6_Missense_Mutation_p.R1144W|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000422127.1_Missense_Mutation_p.R2297W|OBSCN_ENST00000284548.11_Missense_Mutation_p.R2297W|OBSCN_ENST00000366707.4_5'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1724	Ig-like 26.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCGCCCGCTGCGGGACAAGAT	0.662000													5	79					0	0	1	0	0
PET112	5188	broad.mit.edu	37	4	152592397	152592397	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr4:152592397G>A	ENST00000263985.6	-	13	1643	c.1603C>T	c.(1603-1605)Cgg>Tgg	p.R535W	PET112_ENST00000507592.1_5'UTR|PET112_ENST00000515812.1_Missense_Mutation_p.R494W	NM_004564.2	NP_004555.1	O75879	GATB_HUMAN	PET112 homolog (yeast)	535						mitochondrion	ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|translation factor activity, nucleic acid binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	23					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GTCGCTTTCCGGACCAACCCA	0.448000													7	120					0	0	1	0	0
RNF135	84282	broad.mit.edu	37	17	29325769	29325769	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr17:29325769C>T	ENST00000328381.5	+	5	1732	c.859C>T	c.(859-861)Cca>Tca	p.P287S	RNF135_ENST00000324689.4_3'UTR|RNF135_ENST00000535306.2_3'UTR|RNF135_ENST00000443677.2_3'UTR	NM_032322.3	NP_115698.3	Q8IUD6	RN135_HUMAN	ring finger protein 135	287	B30.2/SPRY.				innate immune response|negative regulation of type I interferon production|positive regulation of interferon-beta production|regulation of innate immune response	cytosol	protein binding|ribonucleoprotein binding|ubiquitin-protein ligase activity|zinc ion binding	p.?(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(1)|skin(2)|urinary_tract(1)	10		all_cancers(10;8.65e-08)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Myeloproliferative disorder(56;0.0255)				GTCTCACCGCCCACAACCCTA	0.522000													6	87					0	0	1	0	0
MRPS10	55173	broad.mit.edu	37	6	42176031	42176031	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr6:42176031G>A	ENST00000053468.3	-	7	617	c.602C>T	c.(601-603)tCa>tTa	p.S201L		NM_018141.3	NP_060611.2	P82664	RT10_HUMAN	mitochondrial ribosomal protein S10	201					translation	actin cytoskeleton|mitochondrion|ribosome	structural constituent of ribosome			endometrium(1)|lung(1)	2	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00528)			GAGGCTTTATGACTTGCTTTC	0.393000													10	324					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30100144	30100144	+	Silent	SNP	G	G	A			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr14:30100144G>A	ENST00000331968.5	-	10	1705	c.1476C>T	c.(1474-1476)ttC>ttT	p.F492F	PRKD1_ENST00000415220.2_Silent_p.F500F	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	492	PH.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TAGTGATTTCGAAACAATGAG	0.398000													6	88					0	0	1	0	0
PCDHA7	0	broad.mit.edu	37	5	140215658	140215658	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr5:140215658G>T	ENST00000525929.1	+	1	1690	c.1690G>T	c.(1690-1692)Gca>Tca	p.A564S	PCDHA7_ENST00000378125.3_Missense_Mutation_p.A564S|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACGCGCCGGCACTGCTGGC	0.687000													19	184					1.56452e-12	1.56452e-12	1	1	0
FSCN3	29999	broad.mit.edu	37	7	127235472	127235472	+	Missense_Mutation	SNP	C	C	T	rs146886586		TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr7:127235472C>T	ENST00000265825.5	+	2	475	c.256C>T	c.(256-258)Cgc>Tgc	p.R86C	FSCN3_ENST00000478328.1_3'UTR|FSCN3_ENST00000420086.2_5'UTR	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	86						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						GTGTTATGGCCGCCCAAGGAC	0.562000													8	72					0	0	1	0	0
R3HDM1	23518	broad.mit.edu	37	2	136481598	136481598	+	Silent	SNP	C	C	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr2:136481598C>T	ENST00000264160.4	+	26	3406	c.3036C>T	c.(3034-3036)ggC>ggT	p.G1012G	R3HDM1_ENST00000410054.1_Silent_p.G957G|R3HDM1_ENST00000409478.1_Silent_p.G884G|R3HDM1_ENST00000329971.3_Silent_p.G883G|R3HDM1_ENST00000409606.1_Silent_p.G1013G	NM_001282798.1|NM_015361.2	NP_001269727.1|NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1	1012							nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		TTAAAATTGGCGCCAAGATCC	0.517000													4	110					0	0	1	0	0
OR8K1	390157	broad.mit.edu	37	11	56113902	56113902	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr11:56113902G>A	ENST00000279783.2	+	1	482	c.388G>A	c.(388-390)Gta>Ata	p.V130I		NM_001002907.1	NP_001002907.1	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K, member 1	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V130I(1)		large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					TGATCGCTACGTAGCCATCTG	0.413000										HNSCC(65;0.19)			10	196					0	0	1	0	0
KRT16P2	0	broad.mit.edu	37	17	16734855	16734855	+	RNA	SNP	C	C	T	rs688852	by1000genomes	TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr17:16734855C>T	ENST00000579062.1	-	0	460																		p.R183Q(1)									CACAGTCTGCCGCAGGGCCAG	0.632000													3	47					0	0	1	0	0
IGLV2-8	0	broad.mit.edu	37	22	23165593	23165593	+	RNA	SNP	C	C	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr22:23165593C>T	ENST00000390317.2	+	0	326																											AACTATGTCTCCTGGTACCAA	0.572000													5	433					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000330386.6_Silent_p.Q2644Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													4	73					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155561701	155561701	+	Translation_Start_Site	SNP	A	A	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr6:155561701A>T	ENST00000275246.7	+	0	492				TIAM2_ENST00000528391.2_Missense_Mutation_p.N405I|TIAM2_ENST00000367174.2_Missense_Mutation_p.N445I|TIAM2_ENST00000318981.5_Missense_Mutation_p.N1069I|TIAM2_ENST00000456877.2_Missense_Mutation_p.N381I|TIAM2_ENST00000529824.2_Missense_Mutation_p.N1069I|TIAM2_ENST00000360366.4_Missense_Mutation_p.N1093I|TIAM2_ENST00000456144.1_Missense_Mutation_p.N1069I|TIAM2_ENST00000461783.3_Missense_Mutation_p.N1069I	NM_001010927.2	NP_001010927	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2						apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGGAGTTTTAACGACAGTCAG	0.582000													5	53					0	0	1	0	0
EGR3	1960	broad.mit.edu	37	8	22548994	22548994	+	Splice_Site	SNP	C	C	G			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr8:22548994C>G	ENST00000317216.2	-	2	513	c.156G>C	c.(154-156)gaG>gaC	p.E52D	RP11-459E5.1_ENST00000523627.1_RNA|EGR3_ENST00000522910.1_Splice_Site_p.E14D|EGR3_ENST00000519492.1_Splice_Site_p.R70T|EGR3_ENST00000524088.1_5'UTR	NM_001199881.1|NM_004430.2	NP_001186810.1|NP_004421.2	Q06889	EGR3_HUMAN	early growth response 3	52					circadian rhythm|muscle organ development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		Prostate(55;0.0421)|Breast(100;0.102)		Colorectal(74;0.0145)|BRCA - Breast invasive adenocarcinoma(99;0.053)|COAD - Colon adenocarcinoma(73;0.0608)		CCATTACATTCTCTGCGGAGA	0.667000													5	103					0	0	1	0	0
POM121L9P	0	broad.mit.edu	37	22	24659593	24659593	+	RNA	SNP	C	C	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr22:24659593C>T	ENST00000414583.2	+	0	3118					NR_003714.1																						TCACTGACATCGAAGGCTGCC	0.632000													5	25					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414346	20414346	+	Silent	SNP	G	G	A			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr9:20414346G>A	ENST00000380338.4	-	5	784	c.498C>T	c.(496-498)agC>agT	p.S166S	MLLT3_ENST00000429426.2_Silent_p.S163S|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	166	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S166S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.527000			T	MLL	ALL								4	52					0	0	1	0	0
KIF3C	3797	broad.mit.edu	37	2	26203359	26203359	+	Silent	SNP	C	C	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr2:26203359C>T	ENST00000264712.3	-	1	2007	c.1428G>A	c.(1426-1428)caG>caA	p.Q476Q	KIF3C_ENST00000405914.1_Silent_p.Q476Q	NM_002254.6	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	476					blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCGGTCATCCTGGATGGCTG	0.617000													6	123					0	0	1	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18807930	18807930	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr1:18807930A>G	ENST00000400664.1	+	1	507	c.455A>G	c.(454-456)aAc>aGc	p.N152S		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	152						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GTTGGCAGTAACCCTGACCCT	0.647000													4	71					0	0	1	0	0
POM121L9P	0	broad.mit.edu	37	22	24659591	24659591	+	RNA	SNP	A	A	G			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr22:24659591A>G	ENST00000414583.2	+	0	3116					NR_003714.1																						ACTCACTGACATCGAAGGCTG	0.632000													5	25					0	0	1	0	0
MDM1	56890	broad.mit.edu	37	12	68710032	68710032	+	Splice_Site	SNP	A	A	G			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr12:68710032A>G	ENST00000303145.7	-	8	1093	c.1007T>C	c.(1006-1008)gTt>gCt	p.V336A	MDM1_ENST00000540418.1_Splice_Site_p.V56A|MDM1_ENST00000411698.2_Splice_Site_p.V301A	NM_017440.4	NP_059136.2	Q8TC05	MDM1_HUMAN	Mdm1 nuclear protein homolog (mouse)	336						nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(7)	33			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		GAGTTCTTTAACCTATTCAGG	0.403000													3	36					0	0	1	0	0
ERMARD	55780	broad.mit.edu	37	6	170162587	170162587	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr6:170162587C>T	ENST00000588451.1	+	9	1055	c.542C>T	c.(541-543)gCc>gTc	p.A181V	ERMARD_ENST00000366772.2_Missense_Mutation_p.A307V|ERMARD_ENST00000392095.4_Missense_Mutation_p.A181V|ERMARD_ENST00000366773.3_Missense_Mutation_p.A307V|ERMARD_ENST00000418781.3_Missense_Mutation_p.A307V					ER membrane-associated RNA degradation	307																	AATGTTTTTGCCACACTTAAC	0.383000													4	134					0	0	1	0	0
ZNF783	100289678	broad.mit.edu	37	7	148979001	148979001	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr7:148979001G>A	ENST00000434415.1	+	6	1371	c.1208G>A	c.(1207-1209)gGc>gAc	p.G403D	ZNF783_ENST00000489518.1_Intron	NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	403					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			GTGGTACCCGGCCCTGTCATC	0.746000													3	18					0	0	1	0	0
KLK8	11202	broad.mit.edu	37	19	51499377	51499377	+	Missense_Mutation	SNP	C	C	T	rs56296296	byFrequency	TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr19:51499377C>T	ENST00000600767.1	-	7	1210	c.721G>A	c.(721-723)Gtc>Atc	p.V241I	KLK8_ENST00000598195.1_5'UTR|CTB-147C22.9_ENST00000594512.1_RNA|KLK8_ENST00000391806.2_Missense_Mutation_p.V286I|KLK8_ENST00000593490.1_3'UTR|KLK8_ENST00000320838.5_3'UTR|KLK8_ENST00000347619.4_Missense_Mutation_p.V100I|KLK8_ENST00000291726.7_Missense_Mutation_p.V241I			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	241	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity	p.V286I(1)		central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		TTGGTATAGACGCCAGGTTTG	0.542000													4	174					0	0	1	0	0
PRRC2B	84726	broad.mit.edu	37	9	134366823	134366823	+	Silent	SNP	A	A	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr9:134366823A>T	ENST00000357304.4	+	28	6292	c.6237A>T	c.(6235-6237)ccA>ccT	p.P2079P	PRRC2B_ENST00000372249.1_Silent_p.P176P|PRRC2B_ENST00000465931.1_3'UTR|PRRC2B_ENST00000458550.1_Silent_p.P1385P|PRRC2B_ENST00000405995.1_Silent_p.P1385P	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	2079							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						TGACCATGCCACTGCCTCGGT	0.612000													12	105					0	0	1	0	0
BMS1P20	0	broad.mit.edu	37	22	22663087	22663087	+	RNA	SNP	A	A	G	rs1054158		TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr22:22663087A>G	ENST00000426066.1	+	0	526					NR_027293.1																						GCTGCCACATAAGTTGTCCTT	0.303000													5	36					0	0	1	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr10:51093329C>T	ENST00000402038.3	-	4	294	c.295G>A	c.(295-297)Gca>Aca	p.A99T		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity	p.A584T(1)		endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													4	52					0	0	1	0	0
HM13	81502	broad.mit.edu	37	20	30115327	30115327	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr20:30115327C>T	ENST00000335574.5	+	2	348	c.224C>T	c.(223-225)gCc>gTc	p.A75V	HM13_ENST00000340852.5_Missense_Mutation_p.A75V|HM13_ENST00000398174.3_Missense_Mutation_p.A75V|HM13_ENST00000376127.3_Missense_Mutation_p.A75V	NM_178580.1	NP_848695.1	Q8TCT9	HM13_HUMAN	histocompatibility (minor) 13	75					membrane protein proteolysis	cell surface|endoplasmic reticulum membrane|integral to membrane|plasma membrane	aspartic-type endopeptidase activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	12	all_cancers(5;3.44e-05)|Lung NSC(7;4.38e-06)|all_lung(7;7.65e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		all cancers(5;0.000479)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			AGCCGGGATGCCGCCCGCTTC	0.502000													4	163					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871043	170871043	+	Silent	SNP	G	G	A			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr6:170871043G>A	ENST00000392092.2	+	3	498	c.219G>A	c.(217-219)caG>caA	p.Q73Q	TBP_ENST00000540980.1_Silent_p.Q53Q|TBP_ENST00000230354.6_Silent_p.Q73Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	73	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q73Q(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcaacagcaacagcagc	0.562000													5	50					0	0	1	0	0
MUC1	4582	broad.mit.edu	37	1	155161799	155161799	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr1:155161799T>G	ENST00000368395.1	-	2	405	c.334A>C	c.(334-336)Acc>Ccc	p.T112P	MUC1_ENST00000368396.4_Intron|MUC1_ENST00000338684.5_Intron|MUC1_ENST00000438413.1_Intron|MUC1_ENST00000368393.3_Intron|MUC1_ENST00000337604.5_Intron|MUC1_ENST00000462215.1_Intron|MUC1_ENST00000343256.5_Intron|MUC1_ENST00000457295.2_Intron|MUC1_ENST00000368398.3_Intron|MUC1_ENST00000368392.3_Intron|MUC1_ENST00000368389.2_Intron|MUC1_ENST00000368390.3_Intron|MUC1_ENST00000342482.4_Intron	NM_001204285.1|NM_001204286.1	NP_001191214.1|NP_001191215.1	P15941	MUC1_HUMAN	mucin 1, cell surface associated	892						apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|skin(2)	10	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCTGGCGGGGTGGTGGAGCCC	0.711000			T	IGH@	B-NHL								8	19					0	0	1	0	0
SETDB1	9869	broad.mit.edu	37	1	150936826	150936826	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr1:150936826G>C	ENST00000271640.5	+	22	4052	c.3862G>C	c.(3862-3864)Gga>Cga	p.G1288R	SETDB1_ENST00000368969.4_Missense_Mutation_p.G1287R|CERS2_ENST00000561294.1_Silent_p.S367S	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	1288	Post-SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGAATGCAGAGGACGTCTTCT	0.522000													6	23					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123383037	123383037	+	Silent	SNP	C	C	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr3:123383037C>T	ENST00000360772.3	-	24	4278	c.3900G>A	c.(3898-3900)gcG>gcA	p.A1300A	MYLK_ENST00000354792.5_Silent_p.A100A|MYLK_ENST00000346322.5_Silent_p.A1231A|MYLK_ENST00000475616.1_Silent_p.A1300A|MYLK_ENST00000359169.1_Silent_p.A1300A|MYLK_ENST00000360304.3_Silent_p.A1300A			Q15746	MYLK_HUMAN	myosin light chain kinase	1300	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Ig-like C2-type 8.			A -> G (in Ref. 1; CAA59685).	aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GCTCCTGGCGCGCGGCCAGGA	0.627000													23	216					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													5	58					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2142146	2142146	+	Silent	SNP	C	C	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr16:2142146C>T	ENST00000262304.4	-	40	11521	c.11313G>A	c.(11311-11313)tcG>tcA	p.S3771S	PKD1_ENST00000423118.1_Silent_p.S3770S|RP11-304L19.1_ENST00000570072.1_RNA	NM_001009944.2	NP_001009944	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	3771					calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						CTCCTGCGGCCGAGCACGTGT	0.647000													7	32					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38627374	38627374	+	Silent	SNP	G	G	A			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr3:38627374G>A	ENST00000413689.1	-	16	2788	c.2595C>T	c.(2593-2595)taC>taT	p.Y865Y	SCN5A_ENST00000450102.2_Silent_p.Y865Y|SCN5A_ENST00000449557.2_Silent_p.Y865Y|SCN5A_ENST00000333535.4_Silent_p.Y865Y|SCN5A_ENST00000451551.2_Silent_p.Y865Y|SCN5A_ENST00000423572.2_Silent_p.Y865Y|SCN5A_ENST00000414099.2_Silent_p.Y865Y|SCN5A_ENST00000455624.2_Silent_p.Y865Y|SCN5A_ENST00000443581.1_Silent_p.Y865Y|SCN5A_ENST00000425664.1_Silent_p.Y865Y	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	865					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TCAGCTCCGAGTAGTTCTTGC	0.562000													9	127					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593025	96593025	+	Missense_Mutation	SNP	C	C	T	rs75189823	by1000genomes	TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr2:96593025C>T	ENST00000456556.1	-	28	1960	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N						ankyrin repeat domain 36C									p.D626N(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCTTTCTCATCACTTGTAGCC	0.318000													5	51					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													5	60					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871082	170871082	+	Silent	SNP	G	G	A			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr6:170871082G>A	ENST00000392092.2	+	3	537	c.258G>A	c.(256-258)caG>caA	p.Q86Q	TBP_ENST00000540980.1_Silent_p.Q66Q|TBP_ENST00000230354.6_Silent_p.Q86Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	86	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q86Q(2)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.612000													5	46					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75104854	75104854	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr10:75104854A>G	ENST00000401621.2	-	6	698	c.578T>C	c.(577-579)aTg>aCg	p.M193T	TTC18_ENST00000355577.3_5'UTR|TTC18_ENST00000394865.1_Missense_Mutation_p.M193T|TTC18_ENST00000340329.3_Missense_Mutation_p.M193T|TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000310715.3_Missense_Mutation_p.M193T			Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	193							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					CAGACCGACCATGTAGTTCTG	0.488000													22	247					0	0	1	0	0
CD200R1L	344807	broad.mit.edu	37	3	112546303	112546303	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr3:112546303G>A	ENST00000488794.1	-	5	867	c.278C>T	c.(277-279)cCg>cTg	p.P93L	CD200R1L_ENST00000398214.1_Missense_Mutation_p.P114L|CD200R1L_ENST00000448932.1_Missense_Mutation_p.P93L			Q6Q8B3	MO2R2_HUMAN	CD200 receptor 1-like	114	Ig-like V-type.					integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|urinary_tract(2)	19						GGTGTCCACCGGACGAATCTG	0.453000													5	81					0	0	1	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61288286	61288286	+	Silent	SNP	C	C	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr20:61288286C>T	ENST00000217159.1	+	2	685	c.480C>T	c.(478-480)gtC>gtT	p.V160V	SLCO4A1_ENST00000370507.1_Silent_p.V160V	NM_016354.3	NP_057438.3	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family, member 4A1	160					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(3)|prostate(2)	21	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			TCACCTTCGTCAGCTACTTCG	0.667000													9	73					0	0	1	0	0
SF3B1	23451	broad.mit.edu	37	2	198265579	198265579	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr2:198265579C>T	ENST00000335508.6	-	18	2669	c.2578G>A	c.(2578-2580)Gaa>Aaa	p.E860K		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa						nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGTTCGGCTTCATCTTTCAGA	0.363000			Mis		myelodysplastic syndrome								14	67					0	0	1	0	0
TMEM52	339456	broad.mit.edu	37	1	1850628	1850636	+	In_Frame_Del	DEL	AGCGGCAGG	AGCGGCAGG	-			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr1:1850628_1850636delAGCGGCAGG	ENST00000310991.3	-	1	76_84	c.69_77delCCTGCCGCT	c.(67-78)ctcctgccgctg>ctg	p.23_26LLPL>L		NM_178545.3	NP_848640.1	Q8NDY8	TMM52_HUMAN	transmembrane protein 52	23						integral to membrane				NS(1)|prostate(1)|stomach(1)	3	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CACCTgcggcagcggcaggagcggcagga	0.766													2	4	---	---	---	---					
AC018890.6	0	broad.mit.edu	37	2	175585079	175585079	+	RNA	DEL	A	A	-			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr2:175585079delA	ENST00000442996.1	+	0	217																											TTTCATTCTCAAAAAAAAAAA	0.368											OREG0015078	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	9	---	---	---	---					
SAMD9L	219285	broad.mit.edu	37	7	92760915	92760916	+	Frame_Shift_Ins	INS	-	-	T			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr7:92760915_92760916insT	ENST00000318238.4	-	5	5585_5586	c.4369_4370insA	c.(4369-4371)agafs	p.R1457fs	SAMD9L_ENST00000411955.1_Frame_Shift_Ins_p.R1457fs|SAMD9L_ENST00000437805.1_Frame_Shift_Ins_p.R1457fs	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1457										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CCTGAAGGATCTATTTAAGGAT	0.436													9	173	---	---	---	---					
CALD1	800	broad.mit.edu	37	7	134618474	134618476	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-G9-6347-01A-11D-A31L-08	TCGA-G9-6347-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470a25cd-eea8-4ca6-b91c-86e36397135a	b63236ea-caa8-44c1-ba56-d36c6c394c23	g.chr7:134618474_134618476delGGA	ENST00000361675.2	+	5	1183_1185	c.954_956delGGA	c.(952-957)agggag>agg	p.E321del	CALD1_ENST00000417172.1_Intron|CALD1_ENST00000422748.1_Intron|CALD1_ENST00000361388.2_Intron|CALD1_ENST00000495522.1_Intron|CALD1_ENST00000424922.1_Intron|CALD1_ENST00000361901.2_Intron|CALD1_ENST00000543443.1_Intron|CALD1_ENST00000393118.2_Intron			Q05682	CALD1_HUMAN	caldesmon 1	321	3 X 14 AA tandem repeats of E-E-E-K-R-A- A-E-E-R-Q-R-I-K.				cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(15)|lung(10)	43						aaaggatgagggaggaagagaaa	0.483													3	5	---	---	---	---					
