Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SPNS3	201305	broad.mit.edu	37	17	4349448	4349448	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr17:4349448C>T	ENST00000355530.2	+	4	788	c.508C>T	c.(508-510)Cgc>Tgc	p.R170C	SPNS3_ENST00000333476.2_Missense_Mutation_p.R43C|SPNS3_ENST00000576069.1_3'UTR	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	170					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						GAGGGACCAGCGCACCCGCGT	0.617000													4	63					0	0	1	0	0
RP11-542C16.2	0	broad.mit.edu	37	17	7217479	7217479	+	Splice_Site	SNP	C	C	T			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr17:7217479C>T	ENST00000575474.1	-	13	1809		c.e13-1		GPS2_ENST00000389167.5_Splice_Site|GPS2_ENST00000391950.3_Splice_Site|GPS2_ENST00000380728.2_Splice_Site																							GGTCAGGTCACTGGAGTGAAA	0.493000													6	42					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766817	77766817	+	Missense_Mutation	SNP	A	A	T			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr8:77766817A>T	ENST00000521891.2	+	10	8108	c.7660A>T	c.(7660-7662)Agt>Tgt	p.S2554C	ZFHX4_ENST00000518282.1_Missense_Mutation_p.S2528C|ZFHX4_ENST00000050961.6_Missense_Mutation_p.S2509C|ZFHX4_ENST00000455469.2_Missense_Mutation_p.S2509C	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2509						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACTGCTGGGCAGTTCCCTCAC	0.512000										HNSCC(33;0.089)			20	61					0	0	1	0	0
DTX4	23220	broad.mit.edu	37	11	58959580	58959580	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr11:58959580A>G	ENST00000227451.3	+	6	1335	c.1231A>G	c.(1231-1233)Atc>Gtc	p.I411V	DTX4_ENST00000531902.1_3'UTR|DTX4_ENST00000532982.1_Missense_Mutation_p.I305V	NM_015177.1	NP_055992.1	Q9Y2E6	DTX4_HUMAN	deltex homolog 4 (Drosophila)	411					Notch signaling pathway	cytoplasm	zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	20		all_epithelial(135;0.125)				GGACTGCACCATCTGTATGGA	0.582000													7	49					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74345121	74345121	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr9:74345121C>T	ENST00000377044.4	-	9	2361	c.1822G>A	c.(1822-1824)Gaa>Aaa	p.E608K	TMEM2_ENST00000377066.5_Missense_Mutation_p.E545K	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	608						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		ATACCATCTTCCAAAAAGAAA	0.403000													4	37					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50376383	50376383	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chrX:50376383A>G	ENST00000376020.2	-	4	2715	c.2690T>C	c.(2689-2691)gTc>gCc	p.V897A	SHROOM4_ENST00000460112.3_Missense_Mutation_p.V781A|SHROOM4_ENST00000289292.7_Missense_Mutation_p.V897A	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	897	Cys-rich.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					AGGATCATGGACTAGAGCTCC	0.453000													10	8					0	0	1	0	0
CD48	962	broad.mit.edu	37	1	160654876	160654876	+	Silent	SNP	G	G	A			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr1:160654876G>A	ENST00000368045.3	-	2	225	c.186C>T	c.(184-186)ttC>ttT	p.F62F	CD48_ENST00000368046.3_Silent_p.F62F			P09326	CD48_HUMAN	CD48 molecule	62	Ig-like C2-type 1.				blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|stomach(1)	10	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TCTTCTGGTCGAAAGTATAAA	0.443000													7	63					0	0	1	0	0
FAM71A	149647	broad.mit.edu	37	1	212798295	212798295	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr1:212798295G>T	ENST00000294829.3	+	1	507	c.76G>T	c.(76-78)Ggg>Tgg	p.G26W	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	26										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		CACCACCATGGGGAAACTGCA	0.483000													6	36					8.12818e-05	8.30488e-05	1	1	0
VN1R2	317701	broad.mit.edu	37	19	53762190	53762190	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr19:53762190G>A	ENST00000341702.3	+	1	646	c.562G>A	c.(562-564)Gtg>Atg	p.V188M		NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	188					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		TGTCTTCCAGGTGATCACCAT	0.473000													5	23					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38592387	38592387	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr3:38592387G>A	ENST00000413689.1	-	28	5669	c.5476C>T	c.(5476-5478)Cgt>Tgt	p.R1826C	SCN5A_ENST00000449557.2_Missense_Mutation_p.R1772C|SCN5A_ENST00000425664.1_Missense_Mutation_p.R1808C|SCN5A_ENST00000450102.2_Missense_Mutation_p.R1772C|SCN5A_ENST00000423572.2_Missense_Mutation_p.R1825C|SCN5A_ENST00000443581.1_Missense_Mutation_p.R1825C|SCN5A_ENST00000451551.2_Missense_Mutation_p.R1772C|SCN5A_ENST00000414099.2_Missense_Mutation_p.R1808C|SCN5A_ENST00000333535.4_Missense_Mutation_p.R1826C|SCN5A_ENST00000455624.2_Missense_Mutation_p.R1793C	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1826			R -> C (found in patients with atrial fibrillation).|R -> H (in LQT3; sodium current characterized by slower decay and a 2- to 3-fold increase in late sodium current).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TTGGCGATACGGAGTGGCTCA	0.507000													4	60					0	0	1	0	0
APBB3	10307	broad.mit.edu	37	5	139938336	139938336	+	Missense_Mutation	SNP	C	C	T	rs138766975		TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr5:139938336C>T	ENST00000357560.4	-	13	1738	c.1295G>A	c.(1294-1296)cGc>cAc	p.R432H	APBB3_ENST00000356738.2_Missense_Mutation_p.R437H|APBB3_ENST00000508496.2_Missense_Mutation_p.R209H|APBB3_ENST00000412920.3_Missense_Mutation_p.R430H|APBB3_ENST00000354402.5_Missense_Mutation_p.R439H|APBB3_ENST00000358580.5_3'UTR	NM_006051.3|NM_133173.2	NP_006042.3|NP_573419.2	O95704	APBB3_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 3	432	PID 2.					actin cytoskeleton|cytoplasm				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCCGCAGGCGGGCACGGGC	0.662000													4	63					0	0	1	0	0
PRKAR1B	5575	broad.mit.edu	37	7	716868	716868	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr7:716868C>G	ENST00000406797.1	-	4	612	c.438G>C	c.(436-438)agG>agC	p.R146S	PRKAR1B_ENST00000403562.1_Missense_Mutation_p.R146S|PRKAR1B_ENST00000544935.1_Missense_Mutation_p.R146S|PRKAR1B_ENST00000360274.4_Missense_Mutation_p.R146S|PRKAR1B_ENST00000537384.1_Missense_Mutation_p.R146S	NM_001164761.1	NP_001158233.1	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, beta	146					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity			endometrium(4)|large_intestine(1)|liver(1)|lung(10)|prostate(1)	17		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		CTGCCTACCTCCTCTCGTTGT	0.642000													13	106					0	0	1	0	0
GMPR2	51292	broad.mit.edu	37	14	24702732	24702732	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr14:24702732C>A	ENST00000557854.1	+	2	466	c.189C>A	c.(187-189)taC>taA	p.Y63*	GMPR2_ENST00000420554.2_Nonsense_Mutation_p.Y63*|GMPR2_ENST00000559104.1_Nonsense_Mutation_p.Y63*|GMPR2_ENST00000559836.1_Nonsense_Mutation_p.Y45*|GMPR2_ENST00000559910.1_Nonsense_Mutation_p.Y45*|GMPR2_ENST00000355299.4_Nonsense_Mutation_p.Y45*|GMPR2_ENST00000456667.3_Nonsense_Mutation_p.Y45*|GMPR2_ENST00000348719.7_Nonsense_Mutation_p.Y45*|GMPR2_ENST00000399440.2_Nonsense_Mutation_p.Y45*	NM_001283022.1	NP_001269951.1	Q9P2T1	GMPR2_HUMAN	guanosine monophosphate reductase 2	45					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage	cytosol	GMP reductase activity|metal ion binding			large_intestine(4)|lung(3)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	12				GBM - Glioblastoma multiforme(265;0.0181)		AGCAGACATACTCTGGGGTTC	0.448000													14	50					4.14922e-12	4.43212e-12	1	1	0
PLEKHG1	57480	broad.mit.edu	37	6	151055000	151055000	+	Silent	SNP	G	G	A	rs145506185	byFrequency	TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr6:151055000G>A	ENST00000367328.1	+	3	495	c.183G>A	c.(181-183)ccG>ccA	p.P61P	PLEKHG1_ENST00000358517.2_Silent_p.P61P	NM_001029884.1	NP_001025055.1	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	61					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		CTGCCAGGCCGTTTTCCAGCA	0.572000													13	50					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72973925	72973925	+	Silent	SNP	C	C	T			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr8:72973925C>T	ENST00000262209.4	-	7	1086	c.879G>A	c.(877-879)tcG>tcA	p.S293S		NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	293						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	CAGAATAGGACGATATCATCA	0.423000													9	58					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100350361	100350361	+	RNA	SNP	T	T	C			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr7:100350361T>C	ENST00000542585.1	+	0	2781				ZAN_ENST00000546213.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACGGAAAAACTCACCATCCCC	0.502000													4	97					0	0	1	0	0
RARB	5915	broad.mit.edu	37	3	25502755	25502755	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr3:25502755G>A	ENST00000330688.4	+	2	650	c.229G>A	c.(229-231)Gtg>Atg	p.V77M	RARB_ENST00000404969.1_Missense_Mutation_p.V84M|RARB_ENST00000462272.1_3'UTR|RARB_ENST00000437042.2_5'UTR|RARB_ENST00000458646.1_5'UTR	NM_000965.3	NP_000956.2	P10826	RARB_HUMAN	retinoic acid receptor, beta	84	Modulating.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|kidney(1)|large_intestine(10)|lung(11)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	28					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	TCCCCCTCGAGTGTACAAACC	0.527000													6	61					0	0	1	0	0
TBC1D19	55296	broad.mit.edu	37	4	26622268	26622268	+	Silent	SNP	T	T	A			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr4:26622268T>A	ENST00000264866.4	+	4	530	c.252T>A	c.(250-252)ccT>ccA	p.P84P	TBC1D19_ENST00000511789.1_Intron|TBC1D19_ENST00000515568.1_3'UTR	NM_018317.2	NP_060787.2	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19	84						intracellular	Rab GTPase activator activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	17		Breast(46;0.0503)				CTGCACCTCCTGAACATCTTA	0.368000													6	56					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180359822	180359822	+	Silent	SNP	C	C	T			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr3:180359822C>T	ENST00000273654.4	-	19	2704	c.2085G>A	c.(2083-2085)gcG>gcA	p.A695A	CCDC39_ENST00000442201.2_Silent_p.A611A			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	611					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TTATTTGTGACGCAAGCATTG	0.348000													6	63					0	0	1	0	0
TAAR6	319100	broad.mit.edu	37	6	132891858	132891858	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr6:132891858C>T	ENST00000275198.1	+	1	398	c.398C>T	c.(397-399)gCg>gTg	p.A133V		NM_175067.1	NP_778237.1	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	133						plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(19)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		AGGTACATTGCGGTTACTGAC	0.488000													94	209					0	0	1	0	0
RUNX2	860	broad.mit.edu	37	6	45390445	45390445	+	Silent	SNP	A	A	G			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr6:45390445A>G	ENST00000371438.1	+	2	532	c.174A>G	c.(172-174)caA>caG	p.Q58Q	RUNX2_ENST00000576263.1_Silent_p.Q58Q|RUNX2_ENST00000371436.6_Silent_p.Q58Q|RUNX2_ENST00000541979.1_Silent_p.Q126Q|RUNX2_ENST00000352853.5_Silent_p.Q126Q|RUNX2_ENST00000465038.2_Silent_p.Q58Q|RUNX2_ENST00000359524.5_Silent_p.Q44Q|RUNX2_ENST00000371432.3_Silent_p.Q44Q	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	58	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						agcagcagcaacagcagcagc	0.731000													3	58					0	0	1	0	0
QARS	5859	broad.mit.edu	37	3	49136843	49136843	+	Silent	SNP	G	G	A			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr3:49136843G>A	ENST00000306125.6	-	17	1885	c.1548C>T	c.(1546-1548)ctC>ctT	p.L516L	QARS_ENST00000414533.1_Silent_p.L505L			P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	516					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	TGAGTGTAAAGAGCCGTGGGT	0.567000													9	73					0	0	1	0	0
SEPN1	57190	broad.mit.edu	37	1	26142184	26142184	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr1:26142184G>A	ENST00000361547.2	+	13	1803	c.1748G>A	c.(1747-1749)cGt>cAt	p.R583H	SEPN1_ENST00000374315.1_Missense_Mutation_p.R549H|SEPN1_ENST00000354177.4_Missense_Mutation_p.R549H|RP1-317E23.6_ENST00000527604.1_Intron|SEPN1_ENST00000494537.1_3'UTR	NM_020451.2	NP_065184.2	Q9NZV5	SELN_HUMAN	selenoprotein N, 1	583						endoplasmic reticulum membrane|extracellular region	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		GGACTCCGGCGTGGCCTGCCC	0.607000													4	133					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77642776	77642776	+	Missense_Mutation	SNP	T	T	A			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr13:77642776T>A	ENST00000407578.2	-	70	12361	c.12095A>T	c.(12094-12096)tAt>tTt	p.Y4032F	MYCBP2_ENST00000544440.2_Missense_Mutation_p.Y3994F|MYCBP2_ENST00000357337.6_Missense_Mutation_p.Y3994F	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	3994					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTGAGCCAGATATTGCCGGCC	0.498000													7	31					0	0	1	0	0
EXOC1	55763	broad.mit.edu	37	4	56768605	56768605	+	Silent	SNP	A	A	G			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr4:56768605A>G	ENST00000381295.2	+	18	2781	c.2433A>G	c.(2431-2433)aaA>aaG	p.K811K	EXOC1_ENST00000346134.7_Silent_p.K811K|EXOC1_ENST00000349598.6_Silent_p.K796K	NM_001024924.1	NP_001020095.1	Q9NV70	EXOC1_HUMAN	exocyst complex component 1	811					exocytosis|protein transport	exocyst	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	35	Glioma(25;0.08)|all_neural(26;0.101)					AACTTCGTAAAGTCATTAAGG	0.388000													4	59					0	0	1	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76073188	76073188	+	RNA	SNP	C	C	T			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr15:76073188C>T	ENST00000395215.3	+	0	477																											CCATACTAAACGTGCTGCCCG	0.507000													7	110					0	0	1	0	0
EEF1A2	1917	broad.mit.edu	37	20	62126425	62126425	+	Silent	SNP	C	C	T	rs143957818		TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr20:62126425C>T	ENST00000217182.3	-	4	519	c.354G>A	c.(352-354)gcG>gcA	p.A118A	EEF1A2_ENST00000298049.7_Silent_p.A118A	NM_001958.3	NP_001949.1	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha 2	118						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(14)|stomach(1)	20	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CGCCCACGCCCGCCGCCACGA	0.711000													18	117					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138033555	138033555	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr2:138033555C>T	ENST00000409968.1	+	12	2637	c.2459C>T	c.(2458-2460)aCg>aTg	p.T820M	THSD7B_ENST00000413152.2_Missense_Mutation_p.T789M|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000272643.3_Missense_Mutation_p.T820M					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		CAGGGAATAACGGGCAGCAGT	0.403000													10	31					0	0	1	0	0
FAM169B	283777	broad.mit.edu	37	15	98995217	98995217	+	Silent	SNP	G	G	A	rs61734134		TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr15:98995217G>A	ENST00000558256.1	-	5	456	c.207C>T	c.(205-207)acC>acT	p.T69T	FAM169B_ENST00000332908.4_Silent_p.T69T	NM_182562.2	NP_872368.2	Q8N8A8	F169B_HUMAN	family with sequence similarity 169, member B	69										large_intestine(3)|lung(3)|urinary_tract(1)	7						AGCATGCACCGGTGCCATCAC	0.587000													3	35					0	0	1	0	0
SH3TC2	79628	broad.mit.edu	37	5	148406714	148406714	+	Missense_Mutation	SNP	G	G	A	rs147490172		TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr5:148406714G>A	ENST00000538184.1	-	7	2110	c.1222C>T	c.(1222-1224)Cgg>Tgg	p.R408W	SH3TC2_ENST00000515425.1_Missense_Mutation_p.R861W|SH3TC2_ENST00000394358.2_Missense_Mutation_p.R746W|SH3TC2_ENST00000512049.1_Missense_Mutation_p.R854W			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	861							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCAAGGCCCGAAGATAGCTC	0.567000													5	227					0	0	1	0	0
AC010547.9	0	broad.mit.edu	37	16	71512203	71512203	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr16:71512203T>C	ENST00000561908.1	-	5	704	c.202A>G	c.(202-204)Aga>Gga	p.R68G	ZNF19_ENST00000565637.1_Missense_Mutation_p.R26G|ZNF19_ENST00000288177.5_Missense_Mutation_p.R68G|ZNF19_ENST00000565100.2_5'UTR|ZNF19_ENST00000567225.1_Missense_Mutation_p.R68G|ZNF19_ENST00000564230.1_Missense_Mutation_p.R68G																							ATGTCCCCTCTCTCCAAAAGT	0.488000													7	20					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1584460	1584460	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chrX:1584460G>A	ENST00000381297.4	-	2	1202	c.992C>T	c.(991-993)aCg>aTg	p.T331M		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	331						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCGCACGGACGTGGTCCTGGC	0.701000			T	CRLF2	"""B-ALL, Downs associated ALL"""								9	113					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433550	55433550	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr11:55433550G>T	ENST00000314259.3	+	1	937	c.908G>T	c.(907-909)tGg>tTg	p.W303L		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TGGATGAAATGGGAGGCTTTG	0.418000													5	41					4.096e-09	4.27804e-09	1	1	0
HTR1E	3354	broad.mit.edu	37	6	87725911	87725911	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr6:87725911C>T	ENST00000305344.5	+	2	1562	c.859C>T	c.(859-861)Cgg>Tgg	p.R287W		NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled						G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	CACCAGGGAACGGAAGGCAGC	0.502000													12	149					0	0	1	0	0
C16orf58	64755	broad.mit.edu	37	16	31508234	31508234	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr16:31508234G>A	ENST00000327237.2	-	6	677	c.638C>T	c.(637-639)gCc>gTc	p.A213V	C16orf58_ENST00000430477.2_Missense_Mutation_p.A71V|C16orf58_ENST00000567994.1_Missense_Mutation_p.A168V|C16orf58_ENST00000570164.1_Missense_Mutation_p.A213V			Q96GQ5	CP058_HUMAN	chromosome 16 open reading frame 58	213						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)	14						CACGGTCAGGGCAGCCCGAGT	0.632000													6	6					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49691395	49691395	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr3:49691395C>A	ENST00000296452.4	+	5	4520	c.4406C>A	c.(4405-4407)gCa>gAa	p.A1469E		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	1469					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCTTCCCGGGCATATTCCTAC	0.632000													4	95					0.00198382	0.00198382	1	1	0
SCD	6319	broad.mit.edu	37	10	102112212	102112212	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr10:102112212C>G	ENST00000370355.2	+	3	781	c.400C>G	c.(400-402)Cta>Gta	p.L134V		NM_005063.4	NP_005054.3	O00767	ACOD_HUMAN	stearoyl-CoA desaturase (delta-9-desaturase)	134					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			endometrium(1)|large_intestine(3)|lung(5)	9		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		TCGGCTGCCCCTACGGCTCTT	0.517000													21	173					0	0	1	0	0
NUP107	57122	broad.mit.edu	37	12	69103089	69103089	+	Splice_Site	SNP	G	G	A			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr12:69103089G>A	ENST00000229179.4	+	9	1133	c.801G>A	c.(799-801)caG>caA	p.Q267Q	NUP107_ENST00000539906.1_Splice_Site_p.Q238Q|NUP107_ENST00000378905.2_Splice_Site_p.Q116Q	NM_020401.2	NP_065134.1	P57740	NU107_HUMAN	nucleoporin 107kDa	267					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding		NUP107/LGR5(2)	breast(3)|endometrium(4)|kidney(4)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(2)	39	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			GACAAAGTCAGGTATGACTAG	0.299000													6	59					0	0	1	0	0
FAM21C	253725	broad.mit.edu	37	10	46238880	46238880	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr10:46238880A>G	ENST00000336378.4	+	6	689	c.571A>G	c.(571-573)Aag>Gag	p.K191E	FAM21C_ENST00000359860.4_Missense_Mutation_p.K135E|FAM21C_ENST00000374362.2_Missense_Mutation_p.K191E|FAM21C_ENST00000540872.1_Missense_Mutation_p.K191E|FAM21C_ENST00000537517.1_Missense_Mutation_p.K191E	NM_015262.2	NP_056077.2	A8K5W5	A8K5W5_HUMAN	family with sequence similarity 21, member C	191										central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28						CATTGGGTCAAAGCTGTTCAT	0.348000													11	87					0	0	1	0	0
PADI6	353238	broad.mit.edu	37	1	17721722	17721723	+	RNA	DEL	GA	GA	-	rs58784721		TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr1:17721722_17721723delGA	ENST00000434762.2	+	0	1545							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	tttgttttttgagagtcttgct	0.485													2	4	---	---	---	---					
MUC6	4588	broad.mit.edu	37	11	1030952	1030952	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr11:1030952delG	ENST00000421673.2	-	6	729	c.679delC	c.(679-681)cagfs	p.Q227fs		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	227	VWFD 1.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CTTACGTGCTGGGCCTGCCGG	0.667													2	4	---	---	---	---					
HMGN2P46	0	broad.mit.edu	37	15	45848231	45848231	+	RNA	DEL	T	T	-			TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr15:45848231delT	ENST00000409454.1	+	0	1226																											TTTGTTTAGCTTTTTTTTTTT	0.323													5	6	---	---	---	---					
PKD1L2	114780	broad.mit.edu	37	16	81241347	81241351	+	RNA	DEL	TCTTT	TCTTT	-	rs72082520		TCGA-G9-6354-01A-11D-A30X-08	TCGA-G9-6354-10A-01D-A30X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aea8eed7-1e59-4888-b285-e5aa3d73cbd9	eba48f21-c778-4331-97c5-e28b88cc0627	g.chr16:81241347_81241351delTCTTT	ENST00000337114.4	-	0	760				PKD1L2_ENST00000525539.1_RNA	NM_001076780.1	NP_001070248.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TTTATGTGGGTCttttttttttttt	0.405													3	5	---	---	---	---					
