Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AC226119.5	0	broad.mit.edu	37	4	3954855	3954855	+	RNA	SNP	G	G	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr4:3954855G>T	ENST00000281228.8	-	0	143				FAM86EP_ENST00000313946.8_RNA																							AAAATATCCCGCCGCAGCTCA	0.493000													4	78					0.014758	0.0151464	1	1	0
MYLK	4638	broad.mit.edu	37	3	123419194	123419194	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr3:123419194C>T	ENST00000360772.3	-	19	3499	c.3121G>A	c.(3121-3123)Gcc>Acc	p.A1041T	MYLK_ENST00000360304.3_Missense_Mutation_p.A1041T|MYLK_ENST00000346322.5_Missense_Mutation_p.A972T|MYLK_ENST00000475616.1_Missense_Mutation_p.A1041T|MYLK_ENST00000359169.1_Missense_Mutation_p.A1041T			Q15746	MYLK_HUMAN	myosin light chain kinase	1041	6 X 12 AA approximate tandem repeats.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GCAGGCTTGGCGTTGCCCATT	0.552000													5	310					0	0	1	0	0
PCDHA6	0	broad.mit.edu	37	5	140209185	140209185	+	Silent	SNP	G	G	A			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr5:140209185G>A	ENST00000529310.1	+	1	1623	c.1509G>A	c.(1507-1509)gcG>gcA	p.A503A	PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Silent_p.A503A|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000530339.1_Intron	NM_018909.2|NM_031848.2|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAGCGCGCGTTGTCGAGCT	0.672000													24	125					0	0	1	0	0
C1orf159	54991	broad.mit.edu	37	1	1019513	1019513	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr1:1019513C>T	ENST00000448924.1	-	10	1261	c.830G>A	c.(829-831)cGc>cAc	p.R277H	C1orf159_ENST00000379320.1_Missense_Mutation_p.R241H|C1orf159_ENST00000421241.2_Intron|C1orf159_ENST00000482816.1_Intron|C1orf159_ENST00000379339.1_Missense_Mutation_p.R277H|C1orf159_ENST00000294576.5_Missense_Mutation_p.R241H|C1orf159_ENST00000379319.1_Intron			Q96HA4	CA159_HUMAN	chromosome 1 open reading frame 159	277	Pro-rich.					integral to membrane						all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.96e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.77e-22)|Colorectal(212;6.51e-05)|COAD - Colon adenocarcinoma(227;0.000214)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		TAAAGGGGGGCGGGCAGGGGG	0.657000													7	51					0	0	1	0	0
VPS41	27072	broad.mit.edu	37	7	38807200	38807200	+	Splice_Site	SNP	T	T	C			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr7:38807200T>C	ENST00000310301.4	-	15	1240		c.e15-2		VPS41_ENST00000395969.2_Splice_Site	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)						Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						GCCAATATCCTAGAGAAAGCC	0.368000													9	58					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167279862	167279862	+	Silent	SNP	G	G	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr2:167279862G>T	ENST00000409855.1	-	18	3060	c.2934C>A	c.(2932-2934)atC>atA	p.I978I		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	978					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						CCAGAATGAAGATATAAGTAA	0.323000													6	50					0.0215528	0.0218327	1	1	0
ZNF641	121274	broad.mit.edu	37	12	48741844	48741844	+	Silent	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr12:48741844C>T	ENST00000544117.2	-	2	780	c.72G>A	c.(70-72)ggG>ggA	p.G24G	ZNF641_ENST00000301042.3_Silent_p.G24G|ZNF641_ENST00000547026.1_Silent_p.G10G|ZNF641_ENST00000448928.3_Silent_p.G10G			Q96N77	ZN641_HUMAN	zinc finger protein 641	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	12						CCCATCCTGTCCCCAGCGCTG	0.517000													31	62					0	0	1	0	0
AP5Z1	9907	broad.mit.edu	37	7	4824597	4824597	+	Silent	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr7:4824597C>T	ENST00000348624.4	+	7	943	c.849C>T	c.(847-849)gcC>gcT	p.A283A	AP5Z1_ENST00000401897.1_Silent_p.A283A	NM_014855.2	NP_055670.1	O43299	K0415_HUMAN	adaptor-related protein complex 5, zeta 1 subunit	283					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding										CCTCCTCTGCCGGCCGCCTGC	0.667000													9	30					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183710344	183710344	+	Silent	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr4:183710344C>T	ENST00000511685.1	+	25	5526	c.5403C>T	c.(5401-5403)taC>taT	p.Y1801Y	TENM3_ENST00000406950.2_Silent_p.Y1801Y					teneurin transmembrane protein 3																		GGATCGCCTACGACACGTCTG	0.493000													4	27					0	0	1	0	0
COPB2	9276	broad.mit.edu	37	3	139077851	139077851	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr3:139077851G>A	ENST00000333188.5	-	19	2654	c.2473C>T	c.(2473-2475)Cca>Tca	p.P825S	COPB2_ENST00000507777.1_Missense_Mutation_p.P796S	NM_004766.2	NP_004757.1	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta prime)	825					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	24						GTGACAAGTGGGTATTGTTTG	0.428000													11	117					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17487978	17487978	+	Missense_Mutation	SNP	G	G	C			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr19:17487978G>C	ENST00000252590.4	-	1	181	c.120C>G	c.(118-120)atC>atG	p.I40M		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	40						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CGAGCCCCAGGATGATGAGGA	0.617000													33	75					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433371	55433371	+	Silent	SNP	G	G	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr11:55433371G>T	ENST00000314259.3	+	1	758	c.729G>T	c.(727-729)acG>acT	p.T243T		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						CCCACCTCACGGTGGTTGTAT	0.493000													71	111					1.63007e-36	1.86979e-36	1	1	0
MED12	9968	broad.mit.edu	37	X	70348523	70348523	+	Missense_Mutation	SNP	G	G	C			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chrX:70348523G>C	ENST00000333646.6	+	24	3629	c.3430G>C	c.(3430-3432)Gaa>Caa	p.E1144Q	MED12_ENST00000374102.1_Missense_Mutation_p.E1144Q|MED12_ENST00000374080.3_Missense_Mutation_p.E1144Q	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	1144					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					TTTGCTCCTGGAAGATCTGAT	0.468000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome				OREG0019857	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	14					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135428548	135428548	+	Missense_Mutation	SNP	A	A	G			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chrX:135428548A>G	ENST00000394143.1	+	6	2974	c.2683A>G	c.(2683-2685)Acc>Gcc	p.T895A	GPR112_ENST00000412101.1_Missense_Mutation_p.T690A|GPR112_ENST00000287534.4_Missense_Mutation_p.T832A|GPR112_ENST00000394141.1_Missense_Mutation_p.T690A|GPR112_ENST00000370652.1_Missense_Mutation_p.T895A	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	895					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AAAGCTAAGTACCCCATTGGA	0.398000													71	34					0	0	1	0	0
AMT	275	broad.mit.edu	37	3	49455030	49455030	+	Missense_Mutation	SNP	C	C	G			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr3:49455030C>G	ENST00000273588.3	-	9	1457	c.1155G>C	c.(1153-1155)caG>caC	p.Q385H	AMT_ENST00000476226.1_5'UTR|AMT_ENST00000395338.2_Intron|AMT_ENST00000538581.1_Missense_Mutation_p.Q329H|AMT_ENST00000458307.2_Missense_Mutation_p.Q341H|AMT_ENST00000546031.1_Missense_Mutation_p.Q288H	NM_000481.3	NP_000472.2	P48728	GCST_HUMAN	aminomethyltransferase	385					glycine catabolic process	mitochondrion	aminomethyltransferase activity|transaminase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CTACAGCCATCTGCTGCTTCC	0.572000													32	137					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92763568	92763568	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr7:92763568C>T	ENST00000318238.4	-	5	2933	c.1717G>A	c.(1717-1719)Gga>Aga	p.G573R	SAMD9L_ENST00000411955.1_Missense_Mutation_p.G573R|SAMD9L_ENST00000437805.1_Missense_Mutation_p.G573R	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	573										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TTTTCCATTCCTTTGAGAGCT	0.353000													17	51					0	0	1	0	0
POM121L9P	0	broad.mit.edu	37	22	24659741	24659741	+	RNA	SNP	G	G	A	rs144618782	by1000genomes	TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr22:24659741G>A	ENST00000414583.2	+	0	3266					NR_003714.1																						CTGTGGGAGGGGGGAATGTTC	0.622000													3	27					0	0	1	0	0
CNOT3	4849	broad.mit.edu	37	19	54646887	54646887	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr19:54646887G>A	ENST00000406403.1	+	2	1661	c.58G>A	c.(58-60)Gag>Aag	p.E20K	CNOT3_ENST00000358389.3_5'UTR|CNOT3_ENST00000221232.5_Missense_Mutation_p.E20K			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	20					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding	p.E20K(6)		endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GAAGGTGTCCGAGGGCGTGGA	0.557000													89	198					0	0	1	0	0
IPPK	64768	broad.mit.edu	37	9	95403027	95403027	+	Silent	SNP	G	G	A			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr9:95403027G>A	ENST00000287996.3	-	8	877	c.601C>T	c.(601-603)Ctg>Ttg	p.L201L		NM_022755.5	NP_073592.1	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	201					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(2)|urinary_tract(1)	15						GCCTCCTGCAGCAAACTCTTC	0.448000													4	128					0	0	1	0	0
TAB1	10454	broad.mit.edu	37	22	39826029	39826029	+	Silent	SNP	G	G	A			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr22:39826029G>A	ENST00000216160.6	+	11	1379	c.1317G>A	c.(1315-1317)ccG>ccA	p.P439P	TAB1_ENST00000331454.3_Intron	NM_006116.2	NP_006107.1	Q15750	TAB1_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 1	439					activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|urinary_tract(1)	14						GCCAAAGCCCGACCTTAACCC	0.662000													9	131					0	0	1	0	0
AC226119.5	0	broad.mit.edu	37	4	3954857	3954857	+	RNA	SNP	C	C	A	rs17410899		TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr4:3954857C>A	ENST00000281228.8	-	0	141				FAM86EP_ENST00000313946.8_RNA																							AATATCCCGCCGCAGCTCAGA	0.488000													4	78					0.000602214	0.000626303	1	1	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr1:142713773C>G	ENST00000610091.1	-	0	1885																											TCTTTTTCCACATTGTCATTT	0.284000													4	80					0	0	1	0	0
LMTK2	22853	broad.mit.edu	37	7	97784178	97784178	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr7:97784178G>A	ENST00000297293.5	+	5	852	c.559G>A	c.(559-561)Gaa>Aaa	p.E187K		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	187	Protein kinase.				early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					GAAAAATGGAGAACCTTACTA	0.418000													19	162					0	0	1	0	0
SNX29	92017	broad.mit.edu	37	16	12293501	12293501	+	Missense_Mutation	SNP	G	G	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr16:12293501G>T	ENST00000566228.1	+	14	1708	c.1639G>T	c.(1639-1641)Gct>Tct	p.A547S	SNX29_ENST00000323433.4_Missense_Mutation_p.A162S|SNX29_ENST00000306030.3_Missense_Mutation_p.A162S	NM_032167.3	NP_115543.3	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	162					cell communication		phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	7						ATATGTAGGAGCTGTCCAGAT	0.463000											OREG0006853	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=LOC92017|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	3	39					1	1	1	1	0
CES1	1066	broad.mit.edu	37	16	55846952	55846952	+	Missense_Mutation	SNP	G	G	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr16:55846952G>T	ENST00000422046.2	-	9	1227	c.946C>A	c.(946-948)Caa>Aaa	p.Q316K	CES1_ENST00000361503.4_Missense_Mutation_p.Q316K|CES1_ENST00000360526.3_Missense_Mutation_p.Q317K			P23141	EST1_HUMAN	carboxylesterase 1	316					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	AGAAGGGGTTGACTCTGGGGA	0.547000													18	98					4.96729e-08	5.30752e-08	1	1	0
FLT1	2321	broad.mit.edu	37	13	28919630	28919630	+	Silent	SNP	C	C	T	rs142392658		TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr13:28919630C>T	ENST00000282397.4	-	16	2558	c.2307G>A	c.(2305-2307)gcG>gcA	p.A769A	FLT1_ENST00000540678.1_5'UTR	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	769					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AGAAGAGAGTCGCAGCCACAC	0.398000													8	18					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141215220	141215220	+	Splice_Site	SNP	A	A	G			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr2:141215220A>G	ENST00000389484.3	-	61	10597	c.9626T>C	c.(9625-9627)gTc>gCc	p.V3209A		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3209					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGATTAGGGACTGTAATAGG	0.398000										TSP Lung(27;0.18)			10	116					0	0	1	0	0
CCKAR	886	broad.mit.edu	37	4	26484871	26484871	+	Missense_Mutation	SNP	G	G	C			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr4:26484871G>C	ENST00000295589.3	-	4	855	c.661C>G	c.(661-663)Cct>Gct	p.P221A		NM_000730.2	NP_000721.1	P32238	CCKAR_HUMAN	cholecystokinin A receptor	221					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			NS(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|pancreas(1)|skin(1)	29		Breast(46;0.0503)			Ceruletide(DB00403)	ACAATTCCAGGAATAAGAAAG	0.378000													20	115					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151970809	151970809	+	Silent	SNP	A	A	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr7:151970809A>T	ENST00000355193.2	-	7	1211	c.993T>A	c.(991-993)atT>atA	p.I331I	KMT2C_ENST00000262189.6_Silent_p.I331I					lysine (K)-specific methyltransferase 2C																		GAGCTTGGTCAATGTGTTCTG	0.393000													9	320					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr1:142713774A>G	ENST00000610091.1	-	0	1884																											CTTTTTCCACATTGTCATTTT	0.284000													4	79					0	0	1	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65194559	65194559	+	Silent	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr14:65194559C>T	ENST00000247226.7	+	2	518	c.210C>T	c.(208-210)aaC>aaT	p.N70N	PLEKHG3_ENST00000394691.1_Silent_p.N70N	NM_015549.1	NP_056364.1	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	70					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(5)|kidney(2)|large_intestine(1)|lung(14)|prostate(2)|skin(3)|urinary_tract(2)	29				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		GCTGGTTGAACGTGAAGGGGC	0.652000													7	39					0	0	1	0	0
OR3A3	8392	broad.mit.edu	37	17	3324770	3324770	+	Silent	SNP	T	T	C			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr17:3324770T>C	ENST00000291231.1	+	1	909	c.909T>C	c.(907-909)aaT>aaC	p.N303N		NM_012373.2	NP_036505.2	P47888	OR3A3_HUMAN	olfactory receptor, family 3, subfamily A, member 3	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(1)	9						GCCTCAGAAATACTGATGTTC	0.498000													25	81					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195507220	195507220	+	Missense_Mutation	SNP	G	G	A	rs74208457		TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr3:195507220G>A	ENST00000463781.3	-	2	11690	c.11231C>T	c.(11230-11232)cCt>cTt	p.P3744L	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.P3744L|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	536					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GACAGGAAGAGGGGTGACGTG	0.582000													3	6					0	0	1	0	0
RBM23	0	broad.mit.edu	37	14	23374621	23374621	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr14:23374621C>T	ENST00000359890.3	-	7	692	c.497G>A	c.(496-498)cGc>cAc	p.R166H	RBM23_ENST00000346528.5_Missense_Mutation_p.R132H|RBM23_ENST00000399922.2_Missense_Mutation_p.R150H|RBM23_ENST00000542016.2_5'UTR|RBM23_ENST00000555209.1_5'UTR	NM_001077351.1	NP_001070819.1	Q86U06	RBM23_HUMAN	RNA binding motif protein 23	166	RRM 1.				mRNA processing	nucleus	nucleotide binding|RNA binding			endometrium(3)|kidney(2)|lung(3)|prostate(1)|skin(1)	10	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.0128)		GAAAACTGTGCGGGCATCACG	0.507000													4	152					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183676360	183676360	+	Missense_Mutation	SNP	A	A	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr4:183676360A>T	ENST00000511685.1	+	22	4963	c.4840A>T	c.(4840-4842)Agt>Tgt	p.S1614C	TENM3_ENST00000406950.2_Missense_Mutation_p.S1614C|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3																		CCATGGCAATAGTGGCCTTTT	0.333000													15	34					0	0	1	0	0
DKFZP761J1410	0	broad.mit.edu	37	19	11472140	11472140	+	Silent	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr19:11472140C>T	ENST00000251473.5	+	6	1015	c.639C>T	c.(637-639)tgC>tgT	p.C213C	DKFZP761J1410_ENST00000591608.1_Silent_p.C188C	NM_001170635.1|NM_022737.2	NP_001164106.1|NP_073574.2																					CGGCCCTCTGCGCCTACGCGG	0.697000													9	65					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11576180	11576180	+	Missense_Mutation	SNP	A	A	G			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr1:11576180A>G	ENST00000294484.6	+	6	1849	c.1711A>G	c.(1711-1713)Acc>Gcc	p.T571A	PTCHD2_ENST00000389575.3_Missense_Mutation_p.T571A	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	571	SSD.				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CACCTCCCTGACCACAGCCGC	0.622000													17	74					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30132963	30132963	+	Missense_Mutation	SNP	C	C	G			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr14:30132963C>G	ENST00000331968.5	-	4	867	c.638G>C	c.(637-639)aGc>aCc	p.S213T	PRKD1_ENST00000415220.2_Missense_Mutation_p.S213T	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	213					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GCGGATGGTGCTGACCCCAGT	0.488000													26	185					0	0	1	0	0
RTP1	132112	broad.mit.edu	37	3	186917771	186917771	+	Missense_Mutation	SNP	C	C	A			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr3:186917771C>A	ENST00000312295.4	+	2	735	c.705C>A	c.(703-705)aaC>aaA	p.N235K	RP11-208N14.4_ENST00000356133.3_RNA	NM_153708.2	NP_714919.2	P59025	RTP1_HUMAN	receptor (chemosensory) transporter protein 1	235					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			breast(2)|endometrium(4)|large_intestine(5)|lung(6)|ovary(3)|skin(2)	22	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		CAGGCTGGAACTTCTGCTCTA	0.602000													35	71					2.09667e-21	2.33628e-21	1	1	0
ERO1LB	56605	broad.mit.edu	37	1	236399660	236399660	+	Silent	SNP	G	G	A			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr1:236399660G>A	ENST00000354619.5	-	7	745	c.544C>T	c.(544-546)Ctg>Ttg	p.L182L	ERO1LB_ENST00000327333.8_3'UTR	NM_019891.3	NP_063944.3	Q86YB8	ERO1B_HUMAN	ERO1-like beta (S. cerevisiae)	182					electron transport chain|protein thiol-disulfide exchange|transport	endoplasmic reticulum membrane	flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|unfolded protein binding			NS(1)|endometrium(3)|large_intestine(8)|lung(8)|skin(2)|urinary_tract(1)	23	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.123)|Acute lymphoblastic leukemia(190;0.205)|Prostate(94;0.219)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			TCTGGGTTCAGCAATAGGTCT	0.418000													29	131					0	0	1	0	0
PLAA	9373	broad.mit.edu	37	9	26905927	26905927	+	Missense_Mutation	SNP	A	A	G			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr9:26905927A>G	ENST00000397292.3	-	14	2387	c.1970T>C	c.(1969-1971)cTg>cCg	p.L657P		NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	657	PUL.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		GAGAGCAAGCAGCTGGTTTGC	0.458000													27	56					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116497321	116497321	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr2:116497321T>C	ENST00000410059.1	+	9	1184	c.704T>C	c.(703-705)cTc>cCc	p.L235P	DPP10_ENST00000393147.2_Missense_Mutation_p.L239P|DPP10_ENST00000409163.1_Missense_Mutation_p.L185P|DPP10_ENST00000488208.1_3'UTR|DPP10_ENST00000310323.8_Missense_Mutation_p.L228P	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	235					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						CTAGAGGAACTCCTGCATTCT	0.458000													35	76					0	0	1	0	0
PES1	23481	broad.mit.edu	37	22	30976074	30976074	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr22:30976074C>T	ENST00000402281.1	-	13	1709	c.718G>A	c.(718-720)Gac>Aac	p.D240N	PES1_ENST00000354694.7_Missense_Mutation_p.D379N|PES1_ENST00000402284.3_Missense_Mutation_p.D362N|PES1_ENST00000335214.6_Missense_Mutation_p.D374N|PES1_ENST00000405677.1_Missense_Mutation_p.D240N	NM_001282327.1	NP_001269256.1	O00541	PESC_HUMAN	pescadillo ribosomal biogenesis factor 1	379	Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	29						CCAGGCCGGTCGACAATCTGA	0.572000													63	143					0	0	1	0	0
ZNF140	7699	broad.mit.edu	37	12	133683237	133683237	+	Nonstop_Mutation	SNP	A	A	C			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr12:133683237A>C	ENST00000355557.2	+	5	2657	c.1374A>C	c.(1372-1374)tgA>tgC	p.*458C	ZNF140_ENST00000440550.2_3'UTR|ZNF140_ENST00000544426.1_Nonstop_Mutation_p.*355C	NM_003440.2	NP_003431.2	P52738	ZN140_HUMAN	zinc finger protein 140	0						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.114)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		AACACCAGTGAATTTACACTG	0.343000													16	36					0	0	1	0	0
AACSP1	0	broad.mit.edu	37	5	178194303	178194303	+	RNA	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr5:178194303C>T	ENST00000503486.2	-	0	1334					NR_024035.1																						ATCTGTTTGACGGCAACTTCC	0.522000													5	25					0	0	1	0	0
LMF2	91289	broad.mit.edu	37	22	50943380	50943380	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr22:50943380C>T	ENST00000216080.5	-	10	1381	c.1213G>A	c.(1213-1215)Ggg>Agg	p.G405R	LMF2_ENST00000380796.3_Intron|LMF2_ENST00000474879.2_Missense_Mutation_p.G430R			Q9BU23	LMF2_HUMAN	lipase maturation factor 2	430						endoplasmic reticulum membrane|integral to membrane				breast(1)|cervix(1)|kidney(1)|lung(4)|prostate(1)|skin(2)	10		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGAGGCGCCCGTGGGTCCCG	0.697000													10	14					0	0	1	0	0
MTL5	9633	broad.mit.edu	37	11	68480780	68480780	+	Nonsense_Mutation	SNP	G	G	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr11:68480780G>T	ENST00000255087.5	-	8	1299	c.1116C>A	c.(1114-1116)tgC>tgA	p.C372*		NM_004923.3	NP_004914.2	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific (tesmin)	372	CXC 2.				cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding	p.C372*(1)		breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	15	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			CTGACCTCCTGCAGTTGCACC	0.478000													82	196					3.14276e-30	3.55269e-30	1	1	0
UGDH	7358	broad.mit.edu	37	4	39506062	39506062	+	Missense_Mutation	SNP	A	A	G			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr4:39506062A>G	ENST00000316423.6	-	10	1580	c.1238T>C	c.(1237-1239)aTt>aCt	p.I413T	UGDH_ENST00000507089.1_Missense_Mutation_p.I316T|UGDH_ENST00000506179.1_Missense_Mutation_p.I413T|UGDH_ENST00000501493.2_Missense_Mutation_p.I346T	NM_001184701.1|NM_003359.3	NP_001171630.1|NP_003350.1	O60701	UGDH_HUMAN	UDP-glucose 6-dehydrogenase	413					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			breast(1)|central_nervous_system(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(2)	27					NADH(DB00157)	CTCAGTGCAAATAACAACAGC	0.408000													3	28					0	0	1	0	0
ZNF692	55657	broad.mit.edu	37	1	249150721	249150721	+	Missense_Mutation	SNP	C	C	G			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr1:249150721C>G	ENST00000451251.1	-	5	876	c.531G>C	c.(529-531)agG>agC	p.R177S	ZNF692_ENST00000468455.1_5'UTR|ZNF692_ENST00000366471.3_Missense_Mutation_p.R172S|ZNF692_ENST00000306601.4_Missense_Mutation_p.R172S|ZNF692_ENST00000427146.1_Missense_Mutation_p.R172S|ZNF692_ENST00000366469.5_Missense_Mutation_p.R172S	NM_001136036.2	NP_001129508.1	Q9BU19	ZN692_HUMAN	zinc finger protein 692	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)	17	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			ACCTGGGCAACCTGGCCTCTT	0.527000													9	77					0	0	1	0	0
POM121	9883	broad.mit.edu	37	7	72400574	72400574	+	Silent	SNP	T	T	G			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr7:72400574T>G	ENST00000395270.1	+	8	1446	c.405T>G	c.(403-405)gcT>gcG	p.A135A	POM121_ENST00000358357.3_Silent_p.A135A|POM121_ENST00000434423.2_Silent_p.A400A|POM121_ENST00000446813.1_Silent_p.A135A|POM121_ENST00000257622.4_Silent_p.A135A	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	400	Pore side (Potential).|Required for targeting to the nucleus and nuclear pore complex.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				TGACAGGCGCTTACGCAAGTG	0.512000													68	237					0	0	1	0	0
EMR3	84658	broad.mit.edu	37	19	14774336	14774336	+	Silent	SNP	G	G	A			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr19:14774336G>A	ENST00000253673.5	-	3	193	c.93C>T	c.(91-93)tgC>tgT	p.C31C	EMR3_ENST00000344373.4_Silent_p.C31C|EMR3_ENST00000599900.1_5'UTR|EMR3_ENST00000443157.2_Silent_p.C31C	NM_032571.3	NP_115960.2	Q9BY15	EMR3_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 3	31	EGF-like 1.				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(14)|ovary(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	50						CATTTGGGGGGCACTTAGCAC	0.488000													20	46					0	0	1	0	0
NOTUM	147111	broad.mit.edu	37	17	79914844	79914844	+	Missense_Mutation	SNP	A	A	G			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr17:79914844A>G	ENST00000409678.3	-	7	1185	c.802T>C	c.(802-804)Ttc>Ctc	p.F268L		NM_178493.5	NP_848588.3	Q6P988	NOTUM_HUMAN	notum pectinacetylesterase homolog (Drosophila)	268						extracellular region	hydrolase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	15	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			TTGTCCAGGAACCAGCCGGAG	0.667000													11	36					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126336325	126336325	+	Silent	SNP	T	T	C			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr4:126336325T>C	ENST00000394329.3	+	5	6220	c.6207T>C	c.(6205-6207)gtT>gtC	p.V2069V	FAT4_ENST00000335110.5_Silent_p.V367V	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2069	Cadherin 20.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ATACTGTTGTTTTCAAAGCTC	0.393000													4	237					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72846785	72846785	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr17:72846785G>A	ENST00000293190.5	-	5	1381	c.1235C>T	c.(1234-1236)cCc>cTc	p.P412L	GRIN2C_ENST00000347612.4_Missense_Mutation_p.P412L	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	412					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	GATGACAAAGGGCCGCTCTTC	0.632000													8	94					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43777678	43777678	+	Missense_Mutation	SNP	G	G	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr1:43777678G>T	ENST00000372476.3	+	11	1585	c.1506G>T	c.(1504-1506)gaG>gaT	p.E502D	TIE1_ENST00000433781.2_Missense_Mutation_p.E147D	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	502	Fibronectin type-III 1.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACCCCAGTGAGAACGTGACGT	0.597000													22	123					3.28513e-13	3.60901e-13	1	1	0
SBSN	374897	broad.mit.edu	37	19	36015769	36015769	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr19:36015769C>T	ENST00000452271.2	-	2	1724	c.1696G>A	c.(1696-1698)Gcc>Acc	p.A566T	SBSN_ENST00000518157.1_Missense_Mutation_p.A223T	NM_001166034.1	NP_001159506.1	Q6UWP8	SBSN_HUMAN	suprabasin	223						extracellular region				large_intestine(5)|lung(6)|ovary(1)|prostate(2)	14	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			ACCCCAGAGGCTAACGGCGTG	0.602000													5	29					0	0	1	0	0
NPIPA5	100288332	broad.mit.edu	37	16	15457735	15457735	+	Silent	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr16:15457735C>T	ENST00000360151.4	-	8	833	c.834G>A	c.(832-834)gcG>gcA	p.A278A		NM_001277325.1	NP_001264254.1			nuclear pore complex interacting protein family, member A5																		GATTATCATCCGCTGAGGGTG	0.532000													5	204					0	0	1	0	0
RP11-707M1.1	0	broad.mit.edu	37	11	49598439	49598439	+	RNA	SNP	A	A	G			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr11:49598439A>G	ENST00000527477.1	+	0	1043																											GGACCTATGTATCAGCCGTAC	0.413000													15	42					0	0	1	0	0
KRBA1	84626	broad.mit.edu	37	7	149430771	149430771	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr7:149430771C>T	ENST00000255992.10	+	18	3124	c.2725C>T	c.(2725-2727)Cgg>Tgg	p.R909W	KRBA1_ENST00000485033.2_Missense_Mutation_p.R849W|KRBA1_ENST00000479560.1_3'UTR|KRBA1_ENST00000319551.8_Missense_Mutation_p.R849W	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	910										breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GACCGCTCGCCGGGCACGTCC	0.662000													3	7					0	0	1	0	0
OR3A3	8392	broad.mit.edu	37	17	3324771	3324771	+	Missense_Mutation	SNP	A	A	C			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr17:3324771A>C	ENST00000291231.1	+	1	910	c.910A>C	c.(910-912)Act>Cct	p.T304P		NM_012373.2	NP_036505.2	P47888	OR3A3_HUMAN	olfactory receptor, family 3, subfamily A, member 3	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(1)	9						CCTCAGAAATACTGATGTTCA	0.498000													24	82					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41048475	41048475	+	Missense_Mutation	SNP	C	C	A			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr5:41048475C>A	ENST00000399564.4	-	16	2085	c.1635G>T	c.(1633-1635)ttG>ttT	p.L545F	MROH2B_ENST00000506092.2_Missense_Mutation_p.L100F	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		ATAGGTCTACCAATTTTGGGT	0.478000													21	58					1.22574e-08	1.32788e-08	1	1	0
ADAM21	8747	broad.mit.edu	37	14	70924676	70924676	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr14:70924676T>C	ENST00000603540.1	+	2	718	c.460T>C	c.(460-462)Ttt>Ctt	p.F154L	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Missense_Mutation_p.F154L	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	154					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CTCTGCCACATTTGAACACCT	0.423000													19	83					0	0	1	0	0
TRGC1	0	broad.mit.edu	37	7	38301855	38301856	+	RNA	DEL	GT	GT	-			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr7:38301855_38301856delGT	ENST00000443402.2	-	0	330					NM_001003799.1|NM_001003806.1	NP_001003799.1|NP_001003806.1																					TCAATTGTTCGTGTGTGTGTGT	0.356													13	324	---	---	---	---					
STEAP2-AS1	0	broad.mit.edu	37	7	89748927	89748928	+	RNA	INS	-	-	C	rs138239781	by1000genomes	TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr7:89748927_89748928insC	ENST00000478318.2	-	0	424				DPY19L2P4_ENST00000497063.1_RNA|RP5-1121E10.2_ENST00000471553.1_lincRNA																							GGTGCGGGCCTCCCCCTTCCCC	0.639													7	6	---	---	---	---					
XKR5	389610	broad.mit.edu	37	8	6679301	6679302	+	RNA	DEL	CA	CA	-			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr8:6679301_6679302delCA	ENST00000518724.1	-	0	958							Q6UX68	XKR5_HUMAN	XK, Kell blood group complex subunit-related family, member 5							integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		TGCATTGGTGcacacacacaca	0.401													2	4	---	---	---	---					
RP11-941H19.3	0	broad.mit.edu	37	8	81213789	81213792	+	RNA	DEL	CACA	CACA	-	rs71266069		TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr8:81213789_81213792delCACA	ENST00000522044.1	+	0	404																											CCCCCACCACcacacacacacaca	0.544													2	4	---	---	---	---					
PTEN	5728	broad.mit.edu	37	10	89692968	89692968	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr10:89692968delC	ENST00000371953.3	+	5	1809	c.452delC	c.(451-453)gccfs	p.A151fs		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	151	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(5)|p.R55fs*1(5)|p.Y27fs*1(2)|p.A151D(1)|p.F56fs*2(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GCACAAGAGGCCCTAGATTTC	0.378		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			11	75	---	---	---	---					
BUD13	84811	broad.mit.edu	37	11	116633428	116633428	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr11:116633428delT	ENST00000260210.4	-	4	900	c.877delA	c.(877-879)agafs	p.R293fs	BUD13_ENST00000375445.3_Intron	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	293										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		CTAGAGGCTCTTTCTGGGGCT	0.493													8	210	---	---	---	---					
CAPN15	6650	broad.mit.edu	37	16	602648	602648	+	Frame_Shift_Del	DEL	G	G	-			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr16:602648delG	ENST00000219611.2	+	12	3144	c.2781delG	c.(2779-2781)ccgfs	p.P928fs	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		CCCCAGAGCCGCCGGGCCACG	0.711													2	4	---	---	---	---					
GRWD1	83743	broad.mit.edu	37	19	48949711	48949712	+	Frame_Shift_Ins	INS	-	-	ACTTT			TCGA-HC-A6AL-01A-11D-A30E-08	TCGA-HC-A6AL-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	737965eb-4771-4559-b50a-0a8a12278942	093d9856-cabb-4d96-8609-b309430a7078	g.chr19:48949711_48949712insACTTT	ENST00000253237.5	+	2	490_491	c.257_258insACTTT	c.(256-261)acacttfs	p.-88fs		NM_031485.3	NP_113673.3	Q9BQ67	GRWD1_HUMAN	glutamate-rich WD repeat containing 1							nucleolus				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|stomach(1)	19		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000206)|all cancers(93;0.000207)|Epithelial(262;0.0125)|GBM - Glioblastoma multiforme(486;0.0222)		CTTCCTCTTACACTTTACTTGT	0.579													16	85	---	---	---	---					
