Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TINAGL1	64129	broad.mit.edu	37	1	32050623	32050623	+	Silent	SNP	C	C	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr1:32050623C>T	ENST00000271064.7	+	7	919	c.843C>T	c.(841-843)ttC>ttT	p.F281F	TINAGL1_ENST00000537531.1_3'UTR|TINAGL1_ENST00000457433.2_Silent_p.F250F|TINAGL1_ENST00000481165.1_3'UTR	NM_001204415.1|NM_022164.2	NP_001191344.1|NP_071447.1	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	281					endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity			breast(2)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		CCTGGTGGTTCCTGCGTCGCC	0.637000													20	73					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48428731	48428731	+	Silent	SNP	T	T	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr7:48428731T>A	ENST00000435803.1	+	37	11592	c.11568T>A	c.(11566-11568)gcT>gcA	p.A3856A		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	3856	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GCCACAAGGCTGTGGTCCAAG	0.552000													41	54					0	0	1	0	0
BPI	671	broad.mit.edu	37	20	36952275	36952275	+	Nonsense_Mutation	SNP	G	G	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr20:36952275G>T	ENST00000262865.4	+	8	861	c.772G>T	c.(772-774)Gag>Tag	p.E258*	CTD-2308N23.2_ENST00000437016.1_RNA|BPI_ENST00000489102.1_Intron	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	258					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				CCCCCAGGGGGAGTTTTACAG	0.498000													5	51					0.000602214	0.000634476	1	1	0
CEP104	9731	broad.mit.edu	37	1	3756209	3756209	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr1:3756209G>A	ENST00000378230.3	-	7	1022	c.698C>T	c.(697-699)gCc>gTc	p.A233V		NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	233						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						TAGTTTCTTGGCATAATCATA	0.353000													34	64					0	0	1	0	0
PCDHA4	0	broad.mit.edu	37	5	140187069	140187069	+	Silent	SNP	C	C	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr5:140187069C>T	ENST00000530339.1	+	1	297	c.297C>T	c.(295-297)agC>agT	p.S99S	PCDHA4_ENST00000356878.4_Silent_p.S99S|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Silent_p.S99S	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGGCGGAGCGCGGAGTGCA	0.592000													8	141					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134660767	134660767	+	Missense_Mutation	SNP	G	G	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr10:134660767G>T	ENST00000368586.5	-	42	6111	c.6011C>A	c.(6010-6012)gCc>gAc	p.A2004D	TTC40_ENST00000263170.5_Missense_Mutation_p.A165D	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	165										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						GGACTTTGTGGCACCCTCTTC	0.657000													24	121					1.85244e-09	2.14302e-09	1	1	0
ZNF99	7652	broad.mit.edu	37	19	22939830	22939830	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr19:22939830T>C	ENST00000397104.3	-	6	2500	c.2501A>G	c.(2500-2502)gAa>gGa	p.E834G						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTTGCCACATTCTTCACATTT	0.358000													10	55					0	0	1	0	0
IGHV1OR21-1	0	broad.mit.edu	37	21	10862829	10862829	+	RNA	SNP	A	A	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr21:10862829A>T	ENST00000559480.1	+	0	125																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						GTCTCCTGCAAGGCTTCTGGA	0.587000													48	326					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14513764	14513764	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr18:14513764C>T	ENST00000358970.5	-	10	1429	c.1430G>A	c.(1429-1431)cGg>cAg	p.R477Q		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	477								p.R477Q(12)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AAGTTGTTTCCGGGTATCATT	0.358000													3	42					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103488378	103488378	+	Missense_Mutation	SNP	A	A	G			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr1:103488378A>G	ENST00000358392.2	-	8	1518	c.1201T>C	c.(1201-1203)Tat>Cat	p.Y401H	COL11A1_ENST00000370096.3_Missense_Mutation_p.Y389H|COL11A1_ENST00000512756.1_Intron|COL11A1_ENST00000353414.4_Missense_Mutation_p.Y350H	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	389	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTATCTTCATATTCTTTATAT	0.363000													5	65					0	0	1	0	0
MCM3	4172	broad.mit.edu	37	6	52148178	52148178	+	Silent	SNP	T	T	C			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr6:52148178T>C	ENST00000596288.1	-	2	267	c.240A>G	c.(238-240)aaA>aaG	p.K80K	MCM3_ENST00000229854.7_Silent_p.K35K|MCM3_ENST00000419835.2_Intron	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	35					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					GCTCCCGAACTTTGCTCTGAT	0.448000													5	79					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43937680	43937680	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr2:43937680G>A	ENST00000282406.4	+	14	2377	c.2267G>A	c.(2266-2268)aGt>aAt	p.S756N		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	756	PH 1.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GCATCCTGTAGTATTTTAAGA	0.299000													5	57					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935519	30935519	+	Silent	SNP	C	C	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr19:30935519C>T	ENST00000355537.3	+	2	1197	c.1050C>T	c.(1048-1050)tgC>tgT	p.C350C		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GCGAGGTGTGCGGTCAGGTGT	0.657000													10	210					0	0	1	0	0
WDR66	144406	broad.mit.edu	37	12	122441613	122441613	+	Silent	SNP	C	C	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr12:122441613C>T	ENST00000288912.4	+	22	4247	c.3393C>T	c.(3391-3393)ttC>ttT	p.F1131F		NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	1131							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		CAGAAATATTCGCGACTGAAA	0.408000													19	31					0	0	1	0	0
ZNF337	26152	broad.mit.edu	37	20	25666234	25666234	+	Missense_Mutation	SNP	T	T	G			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr20:25666234T>G	ENST00000376436.1	-	3	758	c.219A>C	c.(217-219)gaA>gaC	p.E73D	ZNF337_ENST00000538750.1_Intron|ZNF337_ENST00000481610.1_5'UTR|ZNF337_ENST00000252979.5_Missense_Mutation_p.E73D					zinc finger protein 337											breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GTCTTCTCTCTTCTCCCCAGG	0.572000													86	142					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48428693	48428693	+	Silent	SNP	C	C	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr7:48428693C>T	ENST00000435803.1	+	37	11554	c.11530C>T	c.(11530-11532)Ctg>Ttg	p.L3844L		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	3844	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GGGAGTCACCCTGGTGTCTGT	0.517000													42	58					0	0	1	0	0
RUNX2	860	broad.mit.edu	37	6	45390466	45390466	+	Silent	SNP	A	A	G			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr6:45390466A>G	ENST00000371438.1	+	2	553	c.195A>G	c.(193-195)caA>caG	p.Q65Q	RUNX2_ENST00000576263.1_Silent_p.Q65Q|RUNX2_ENST00000352853.5_Silent_p.Q133Q|RUNX2_ENST00000371436.6_Silent_p.Q65Q|RUNX2_ENST00000541979.1_Silent_p.Q133Q|RUNX2_ENST00000359524.5_Silent_p.Q51Q|RUNX2_ENST00000371432.3_Silent_p.Q51Q|RUNX2_ENST00000465038.2_Silent_p.Q65Q	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	65	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						agcagcagcaacagcagcagc	0.731000													3	47					0	0	1	0	0
TRPC1	7220	broad.mit.edu	37	3	142499733	142499733	+	Silent	SNP	A	A	C			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr3:142499733A>C	ENST00000273482.6	+	5	1111	c.720A>C	c.(718-720)gcA>gcC	p.A240A	TRPC1_ENST00000476941.1_Silent_p.A274A	NM_003304.4	NP_003295.1	P48995	TRPC1_HUMAN	transient receptor potential cation channel, subfamily C, member 1	274					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(2)|stomach(3)|urinary_tract(1)	37						ATTTACTTGCACAAGCCCGGA	0.378000													4	55					0	0	1	0	0
OASL	8638	broad.mit.edu	37	12	121471396	121471396	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr12:121471396C>T	ENST00000257570.5	-	2	619	c.349G>A	c.(349-351)Gac>Aac	p.D117N	OASL_ENST00000339275.5_Missense_Mutation_p.D117N	NM_003733.3	NP_003724.1	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like	117					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			NS(1)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCCAGCAGGTCCTGGCTTTGC	0.582000													7	124					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													7	56					0	0	1	0	0
FAM161A	84140	broad.mit.edu	37	2	62066623	62066623	+	Missense_Mutation	SNP	G	G	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr2:62066623G>T	ENST00000404929.1	-	3	1527	c.1516C>A	c.(1516-1518)Cct>Act	p.P506T	FAM161A_ENST00000405894.3_Missense_Mutation_p.P506T	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	506					response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						CAAGGCACAGGGTTTACACCT	0.473000													10	71					2.80697e-09	3.18484e-09	1	1	0
DPPA2	151871	broad.mit.edu	37	3	109027103	109027103	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr3:109027103C>T	ENST00000478945.1	-	6	680	c.434G>A	c.(433-435)cGa>cAa	p.R145Q		NM_138815.3	NP_620170.3	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	145						nucleus	nucleic acid binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CCTCGAACATCGCTGTAATCT	0.438000													19	38					0	0	1	0	0
GPR108	56927	broad.mit.edu	37	19	6734270	6734270	+	Silent	SNP	G	G	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr19:6734270G>A	ENST00000264080.7	-	5	449	c.423C>T	c.(421-423)ccC>ccT	p.P141P	GPR108_ENST00000430424.4_5'UTR	NM_001080452.1	NP_001073921.1	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108	141						integral to membrane				breast(2)|cervix(1)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	13						GGAGGAGCCCGGGAAAGATAA	0.642000											OREG0025092	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	41					0	0	1	0	0
GPATCH4	54865	broad.mit.edu	37	1	156565530	156565530	+	Missense_Mutation	SNP	C	C	G			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr1:156565530C>G	ENST00000368232.4	-	8	720	c.588G>C	c.(586-588)caG>caC	p.Q196H	GPATCH4_ENST00000438976.2_Missense_Mutation_p.Q201H|GPATCH4_ENST00000497287.1_5'UTR	NM_015590.3|NM_182679.2	NP_056405.2|NP_872620.1	Q5T3I0	GPTC4_HUMAN	G patch domain containing 4	196						intracellular	nucleic acid binding			autonomic_ganglia(1)|breast(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(3)|stomach(1)	17	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGCTCTCTGACTGCAGTTGAG	0.537000													29	47					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092295	151092295	+	Silent	SNP	A	A	G			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chrX:151092295A>G	ENST00000360243.2	+	3	426	c.159A>G	c.(157-159)gaA>gaG	p.E53E	MAGEA4_ENST00000393921.1_Silent_p.E53E|MAGEA4_ENST00000276344.2_Silent_p.E53E|MAGEA4_ENST00000370340.3_Silent_p.E53E|MAGEA4_ENST00000370335.1_Silent_p.E53E|MAGEA4_ENST00000393920.1_Silent_p.E53E|MAGEA4_ENST00000370337.4_Silent_p.E53E	NM_001011550.1	NP_001011550.1	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	53				E -> K (in Ref. 3; BAA06841).			protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					CCCTGGAGGAAGTGCCTGCTG	0.622000													34	44					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50682160	50682160	+	Silent	SNP	C	C	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr22:50682160C>A	ENST00000439308.2	-	1	1221	c.729G>T	c.(727-729)ggG>ggT	p.G243G	TUBGCP6_ENST00000248846.5_Silent_p.G243G	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	243					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TAATAGCCAGCCCAGAGAGGT	0.527000													8	52					0.307466	0.307466	1	1	0
MYH1	4619	broad.mit.edu	37	17	10408221	10408221	+	Missense_Mutation	SNP	T	T	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr17:10408221T>A	ENST00000226207.5	-	22	2691	c.2597A>T	c.(2596-2598)gAg>gTg	p.E866V	RP11-799N11.1_ENST00000399342.2_RNA|CTC-297N7.11_ENST00000587182.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	866						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CTTAGCCAGCTCTTCTTTGGT	0.423000													5	111					0	0	1	0	0
ABCC4	10257	broad.mit.edu	37	13	95899954	95899954	+	Missense_Mutation	SNP	T	T	G			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr13:95899954T>G	ENST00000376887.4	-	2	242	c.128A>C	c.(127-129)gAt>gCt	p.D43A	ABCC4_ENST00000431522.1_Missense_Mutation_p.D43A|ABCC4_ENST00000538287.1_3'UTR|ABCC4_ENST00000412704.1_Missense_Mutation_p.D43A|ABCC4_ENST00000536256.1_Missense_Mutation_p.D43A	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	43					platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	TGAATACATATCATCTTCCTC	0.458000													21	47					0	0	1	0	0
ADRA2A	150	broad.mit.edu	37	10	112837941	112837941	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr10:112837941G>A	ENST00000280155.2	+	1	1152	c.187G>A	c.(187-189)Gtg>Atg	p.V63M		NM_000681.3	NP_000672.3	P08913	ADA2A_HUMAN	adrenoceptor alpha 2A	48					actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding			breast(1)|cervix(3)|endometrium(6)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	GCTGCTCACCGTGTTCGGCAA	0.697000													3	21					0	0	1	0	0
MESP2	145873	broad.mit.edu	37	15	90320476	90320476	+	Silent	SNP	G	G	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr15:90320476G>A	ENST00000341735.3	+	1	888	c.888G>A	c.(886-888)gcG>gcA	p.A296A	MESP2_ENST00000558723.1_Intron|MESP2_ENST00000560219.1_Intron	NM_001039958.1	NP_001035047.1	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog (mouse)	296					Notch signaling pathway	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			CCTGGACGGCGGCCCCAGCAA	0.627000													4	25					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155298459	155298459	+	Silent	SNP	G	G	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr4:155298459G>T	ENST00000357232.4	-	3	371	c.372C>A	c.(370-372)atC>atA	p.I124I	DCHS2_ENST00000339452.1_Silent_p.I730I	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2		Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TTTCCCTGTCGATATCTTGAG	0.403000													4	88					0.00024832	0.00026638	1	1	0
RORA	6095	broad.mit.edu	37	15	60919520	60919520	+	Silent	SNP	C	C	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr15:60919520C>T	ENST00000261523.5	-	1	142	c.54G>A	c.(52-54)ccG>ccA	p.P18P	RORA_ENST00000309157.4_Silent_p.P18P|RORA_ENST00000335670.6_Intron|RORA_ENST00000560004.1_Intron|RP11-219B17.1_ENST00000558235.1_RNA|RP11-219B17.1_ENST00000559824.1_RNA	NM_134260.2	NP_599022.1	P35398	RORA_HUMAN	RAR-related orphan receptor A	18	Modulating.		P -> S (in a colorectal cancer sample; somatic mutation).		positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	21						TGATTGACCACGGCACTCTTG	0.552000													41	68					0	0	1	0	0
KIAA0586	9786	broad.mit.edu	37	14	58917402	58917402	+	Missense_Mutation	SNP	A	A	G			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr14:58917402A>G	ENST00000423743.3	+	9	1193	c.935A>G	c.(934-936)gAa>gGa	p.E312G	KIAA0586_ENST00000261244.5_Missense_Mutation_p.E356G|KIAA0586_ENST00000354386.6_Missense_Mutation_p.E409G|KIAA0586_ENST00000538571.2_3'UTR|KIAA0586_ENST00000556134.1_Missense_Mutation_p.E341G	NM_001244191.1|NM_001244192.1	NP_001231120.1|NP_001231121.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	356										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AGGGATGATGAACTATCAAAG	0.378000													4	17					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													4	57					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123811140	123811140	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr11:123811140G>A	ENST00000307033.2	+	1	891	c.817G>A	c.(817-819)Gtg>Atg	p.V273M		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	273					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GGCCGTCTCTGTGCTATACAC	0.483000													53	85					0	0	1	0	0
TLE1	7088	broad.mit.edu	37	9	84199168	84199168	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr9:84199168T>C	ENST00000376499.3	-	20	3322	c.2258A>G	c.(2257-2259)tAc>tGc	p.Y753C		NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	753					negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						AGTGACTATGTACTTATCATC	0.418000													13	54					0	0	1	0	0
DGKA	1606	broad.mit.edu	37	12	56335369	56335369	+	Splice_Site	SNP	G	G	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr12:56335369G>A	ENST00000331886.5	+	15	1704		c.e15+1		DGKA_ENST00000394147.1_Splice_Site|DGKA_ENST00000549079.2_Splice_Site|DGKA_ENST00000551156.1_Splice_Site	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	CTGAGATAGGGTGAGCACAGG	0.473000													33	61					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	667826	667826	+	Splice_Site	SNP	G	G	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr12:667826G>T	ENST00000266383.5	+	18	2773	c.2760G>T	c.(2758-2760)gaG>gaT	p.E920D		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	920						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			AGTGGCCTGAGGGTGAGCCCT	0.567000													4	42					0.00116845	0.00118859	1	1	0
GLB1L2	89944	broad.mit.edu	37	11	134240925	134240925	+	Silent	SNP	C	C	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr11:134240925C>T	ENST00000535456.2	+	13	1427	c.1239C>T	c.(1237-1239)atC>atT	p.I413I	GLB1L2_ENST00000389881.3_Silent_p.I413I|GLB1L2_ENST00000529077.1_3'UTR|GLB1L2_ENST00000339772.7_Silent_p.I413I	NM_138342.3	NP_612351.2	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2	413					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		AAAAGCCCATCAACATGGAGA	0.572000													9	196					0	0	1	0	0
FOXA1	3169	broad.mit.edu	37	14	38061192	38061192	+	Missense_Mutation	SNP	A	A	G			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr14:38061192A>G	ENST00000250448.2	-	2	858	c.797T>C	c.(796-798)tTc>tCc	p.F266S	FOXA1_ENST00000540786.1_Missense_Mutation_p.F233S|FOXA1_ENST00000545425.2_5'UTR	NM_004496.3	NP_004487.2	P55317	FOXA1_HUMAN	forkhead box A1	266					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		CTCGCACTTGAAGCGCTTCTG	0.726000													5	21					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52601966	52601966	+	Missense_Mutation	SNP	G	G	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr20:52601966G>T	ENST00000395961.3	-	7	1166	c.1000C>A	c.(1000-1002)Caa>Aaa	p.Q334K	BCAS1_ENST00000371435.2_Missense_Mutation_p.Q334K|BCAS1_ENST00000434986.2_Missense_Mutation_p.Q92K|BCAS1_ENST00000371440.3_Missense_Mutation_p.Q379K	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	334						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CCAGCCCCTTGGGTCTCCTGG	0.502000													89	157					5.60141e-34	6.60966e-34	1	1	0
PHIP	55023	broad.mit.edu	37	6	79692791	79692791	+	Missense_Mutation	SNP	T	T	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr6:79692791T>A	ENST00000275034.4	-	23	2748	c.2581A>T	c.(2581-2583)Att>Ttt	p.I861F		NM_017934.5	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	861					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		TGCAGATTAATTCCTGCATCT	0.363000													7	82					0	0	1	0	0
MFSD2B	388931	broad.mit.edu	37	2	24247038	24247038	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr2:24247038G>A	ENST00000338315.4	+	13	1387	c.1387G>A	c.(1387-1389)Gcc>Acc	p.A463T	MFSD2B_ENST00000406420.3_Missense_Mutation_p.A463T			A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing 2B	463					transport	integral to membrane		p.A463T(1)		cervix(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	10						CCTCATTGGCGCCGTGCCCAC	0.607000													7	32					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64416297	64416297	+	Silent	SNP	G	G	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr11:64416297G>T	ENST00000265459.6	-	16	3653	c.3192C>A	c.(3190-3192)ggC>ggA	p.G1064G	NRXN2_ENST00000377551.1_Silent_p.G1064G|NRXN2_ENST00000377559.3_Silent_p.G1024G|AP001092.4_ENST00000433606.1_RNA|NRXN2_ENST00000409571.1_Silent_p.G1057G	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1064	Laminin G-like 5.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						AGGCCAGGCAGCCCTGAAAGC	0.617000													8	118					7.48243e-07	8.17525e-07	1	1	0
FOXP2	93986	broad.mit.edu	37	7	114269973	114269973	+	Silent	SNP	A	A	G	rs149757187		TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr7:114269973A>G	ENST00000393500.3	+	11	1105	c.285A>G	c.(283-285)caA>caG	p.Q95Q	FOXP2_ENST00000393491.3_Silent_p.Q78Q|FOXP2_ENST00000403559.4_Silent_p.Q187Q|FOXP2_ENST00000378237.3_Silent_p.Q170Q|FOXP2_ENST00000393494.2_Silent_p.Q170Q|AC020606.1_ENST00000580664.1_RNA|FOXP2_ENST00000350908.4_Silent_p.Q170Q|FOXP2_ENST00000390668.3_Silent_p.Q194Q|FOXP2_ENST00000393498.2_Silent_p.Q150Q|FOXP2_ENST00000393489.3_Silent_p.Q78Q|FOXP2_ENST00000408937.3_Silent_p.Q195Q|FOXP2_ENST00000360232.4_Silent_p.Q170Q			O15409	FOXP2_HUMAN	forkhead box P2	170	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q195Q(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						agcagcagcaacaacaacaac	0.502000													3	57					0	0	1	0	0
PABPC5	140886	broad.mit.edu	37	X	90691469	90691469	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chrX:90691469G>A	ENST00000312600.3	+	2	1107	c.893G>A	c.(892-894)cGg>cAg	p.R298Q	PABPC5_ENST00000373105.1_Missense_Mutation_p.R134Q	NM_080832.2	NP_543022.1	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	298						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(1)|pancreas(1)	42						GAAAAAAGTCGGCCCCCAGGG	0.453000													4	31					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113256714	113256714	+	Silent	SNP	G	G	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr8:113256714G>A	ENST00000297405.5	-	65	10555	c.10311C>T	c.(10309-10311)acC>acT	p.T3437T	CSMD3_ENST00000352409.3_Silent_p.T3367T|CSMD3_ENST00000455883.2_Silent_p.T3268T|CSMD3_ENST00000343508.3_Silent_p.T3397T	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3437	Sushi 28.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CAGGCTGACAGGTATAAATCA	0.438000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			90	45					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101592010	101592010	+	Silent	SNP	C	C	G			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr15:101592010C>G	ENST00000284395.5	+	25	3925	c.3525C>G	c.(3523-3525)ccC>ccG	p.P1175P	LRRK1_ENST00000388948.3_Silent_p.P1178P|RP11-505E24.2_ENST00000559857.1_RNA			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1178					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ACACGGACCCCAGTGAGAAAT	0.617000													4	60					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73836863	73836863	+	Silent	SNP	C	C	T			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr17:73836863C>T	ENST00000207549.4	-	8	1042	c.663G>A	c.(661-663)acG>acA	p.T221T	UNC13D_ENST00000587504.1_5'UTR|UNC13D_ENST00000412096.2_Silent_p.T221T	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	221	C2 1.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			CATGCAGATCCGTGAGCTCCC	0.592000									Familial Hemophagocytic Lymphohistiocytosis				45	138					0	0	1	0	0
EML2	24139	broad.mit.edu	37	19	46119742	46119742	+	Missense_Mutation	SNP	C	C	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr19:46119742C>A	ENST00000536630.1	-	18	2065	c.1927G>T	c.(1927-1929)Gtc>Ttc	p.V643F	EML2_ENST00000245925.3_Missense_Mutation_p.V496F|EML2_ENST00000589876.1_Missense_Mutation_p.V496F|EML2_ENST00000587152.1_Missense_Mutation_p.V697F	NM_001193269.1	NP_001180198.1	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like 2	496					sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|urinary_tract(1)	31		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		AGGCGGCTGACCTTGCGGCCG	0.672000													29	49					8.53417e-09	9.50031e-09	1	1	0
ACCSL	390110	broad.mit.edu	37	11	44069763	44069763	+	Silent	SNP	G	G	A			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr11:44069763G>A	ENST00000378832.1	+	1	233	c.177G>A	c.(175-177)agG>agA	p.R59R		NM_001031854.2	NP_001027025.2	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like	59							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(14)|ovary(5)|pancreas(1)|skin(2)	34						AGGAAAGGAGGCACACTGAGG	0.587000													4	103					0	0	1	0	0
HABP4	22927	broad.mit.edu	37	9	99212613	99212614	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr9:99212613_99212614delGA	ENST00000375249.4	+	1	127_128	c.52_53delGA	c.(52-54)gagfs	p.E18fs	HABP4_ENST00000375251.3_Frame_Shift_Del_p.E18fs	NM_014282.2	NP_055097.2	Q5JVS0	HABP4_HUMAN	hyaluronan binding protein 4	18					platelet activation|platelet degranulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|extracellular region|nucleus	protein binding			NS(1)|cervix(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	13		Acute lymphoblastic leukemia(62;0.0169)|all_hematologic(171;0.214)				CGCGATGCAGGAGAGTTTCGGC	0.733													2	4	---	---	---	---					
UNC13C	440279	broad.mit.edu	37	15	54799323	54799323	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr15:54799323delT	ENST00000545554.1	+	22	5310	c.5310delT	c.(5308-5310)aatfs	p.N1770fs	UNC13C_ENST00000260323.11_Frame_Shift_Del_p.N1770fs|UNC13C_ENST00000537900.1_Frame_Shift_Del_p.N1768fs			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1770	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AGACTATCAATAAAGTGCTGC	0.318													2	4	---	---	---	---					
ANKRD20A11P	0	broad.mit.edu	37	21	15347257	15347258	+	RNA	INS	-	-	A	rs80199214		TCGA-HC-A6AO-01A-11D-A30E-08	TCGA-HC-A6AO-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	78928ca5-e8a3-4c7c-a8ca-a0e5801870f9	300a9b2e-8abd-4a19-a4fc-b5e4b266e1df	g.chr21:15347257_15347258insA	ENST00000344693.5	-	0	736					NR_027270.1																						ACCCTGCACAGAAAAAAAGTTG	0.307													5	1	---	---	---	---					
