Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MUC16	94025	broad.mit.edu	37	19	9073638	9073638	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr19:9073638C>T	ENST00000397910.4	-	3	14011	c.13808G>A	c.(13807-13809)cGa>cAa	p.R4603Q		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4605	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.R4603Q(3)|p.R236Q(2)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTCTCTTTTCGTCCAGCAGT	0.502000													5	71					0	0	1	0	0
CYP1A1	1543	broad.mit.edu	37	15	75013055	75013055	+	Silent	SNP	A	A	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr15:75013055A>T	ENST00000379727.3	-	7	1512	c.1314T>A	c.(1312-1314)gcT>gcA	p.A438A	CYP1A1_ENST00000395048.2_Silent_p.A438A|CYP1A1_ENST00000395049.4_Silent_p.A409A|CYP1A1_ENST00000567032.1_Silent_p.A438A			P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 1	438					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(7)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	CCTTGTCGATAGCACCATCAG	0.527000									Endometrial Cancer, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				6	283					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6224992	6224992	+	Silent	SNP	T	T	C			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr6:6224992T>C	ENST00000264870.3	-	7	1165	c.900A>G	c.(898-900)ctA>ctG	p.L300L		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	300					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GGTATTCCAATAGAATGTCAA	0.478000													5	254					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180053141	180053141	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr5:180053141G>A	ENST00000261937.6	-	9	1306	c.1228C>T	c.(1228-1230)Cgc>Tgc	p.R410C	FLT4_ENST00000424276.2_5'UTR|FLT4_ENST00000393347.3_Missense_Mutation_p.R410C|FLT4_ENST00000502649.1_Missense_Mutation_p.R410C	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	410	Ig-like C2-type 4.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTGATGTTGCGCCTCAGGCCA	0.667000													17	197					0	0	1	0	0
CD69	969	broad.mit.edu	37	12	9913395	9913395	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr12:9913395C>T	ENST00000228434.3	-	1	102	c.22G>A	c.(22-24)Gta>Ata	p.V8I	CD69_ENST00000536709.1_Missense_Mutation_p.V8I	NM_001781.2	NP_001772.1	Q07108	CD69_HUMAN	CD69 molecule	8						integral to plasma membrane	sugar binding|transmembrane receptor activity			endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)	10						TTCTCTGCTACGAAACAATTT	0.393000													4	174					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	131976470	131976470	+	Silent	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr2:131976470C>T	ENST00000356920.5	+	1	589	c.495C>T	c.(493-495)gaC>gaT	p.D165D	POTEE_ENST00000358087.5_Silent_p.D165D|PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	165							ATP binding										GGGACACTGACGTGAACAAGA	0.592000													16	443					0	0	1	0	0
HADH	3033	broad.mit.edu	37	4	108953498	108953498	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr4:108953498G>A	ENST00000403312.1	+	7	944	c.902G>A	c.(901-903)gGt>gAt	p.G301D	HADH_ENST00000454409.2_Intron|HADH_ENST00000309522.3_Intron|HADH_ENST00000603302.1_Missense_Mutation_p.G242D|HADH_ENST00000510728.1_Intron|HADH_ENST00000505878.1_Intron	NM_001184705.2	NP_001171634.2	Q16836	HCDH_HUMAN	hydroxyacyl-CoA dehydrogenase	236					fatty acid beta-oxidation	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|NAD+ binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	15		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000168)	NADH(DB00157)	CAAACGTGTGGTGATTCTAAC	0.423000													8	358					0	0	1	0	0
AP2A2	161	broad.mit.edu	37	11	977124	977124	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr11:977124C>T	ENST00000448903.2	+	5	644	c.503C>T	c.(502-504)gCg>gTg	p.A168V	AP2A2_ENST00000534328.1_Missense_Mutation_p.A168V|AP2A2_ENST00000332231.5_Missense_Mutation_p.A168V	NM_001242837.1|NM_012305.3	NP_001229766.1|NP_036437.1	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2 subunit	168					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)	21		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		AAGCAGAGCGCGGCCCTGTGC	0.612000													4	81					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75107127	75107127	+	Missense_Mutation	SNP	C	C	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr1:75107127C>A	ENST00000326665.5	-	5	550	c.332G>T	c.(331-333)aGg>aTg	p.R111M		NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	111										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TTCAACAGACCTTCTTGTGTG	0.408000													7	105					8.12818e-05	8.50333e-05	1	1	0
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	Missense_Mutation	SNP	C	C	A	rs79307257	by1000genomes	TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr2:96593016C>A	ENST00000456556.1	-	28	1969	c.1885G>T	c.(1885-1887)Gat>Tat	p.D629Y						ankyrin repeat domain 36C									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000													4	98					0.014758	0.0149783	1	1	0
LZTS1	11178	broad.mit.edu	37	8	20107496	20107496	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr8:20107496C>T	ENST00000381569.1	-	4	1885	c.1528G>A	c.(1528-1530)Gag>Aag	p.E510K	LZTS1_ENST00000265801.6_Missense_Mutation_p.E510K|LZTS1_ENST00000522290.1_Intron			Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	510					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(2)|skin(1)|urinary_tract(1)	29				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		TCCCGCAGCTCGGCCCGCAGC	0.701000													4	154					0	0	1	0	0
TLDC2	140711	broad.mit.edu	37	20	35504580	35504580	+	Translation_Start_Site	SNP	G	G	C			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr20:35504580G>C	ENST00000217320.3	+	1	47	c.3G>C	c.(1-3)atG>atC	p.M1I	TLDC2_ENST00000602922.1_Start_Codon_SNP_p.M1I	NM_080628.1	NP_542195.1			TBC/LysM-associated domain containing 2																		ACAGGAGAATGAGAGGCCTCC	0.617000													7	284					0	0	1	0	0
TRBV5-4	0	broad.mit.edu	37	7	142168890	142168890	+	RNA	SNP	C	C	T	rs143671051	by1000genomes	TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr7:142168890C>T	ENST00000454561.2	-	0	155																											GGGCTTGGTCCTCCTGGGGAA	0.592000													4	35					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414346	20414346	+	Silent	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr9:20414346G>A	ENST00000380338.4	-	5	784	c.498C>T	c.(496-498)agC>agT	p.S166S	MLLT3_ENST00000429426.2_Silent_p.S163S|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	166	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S166S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.527000			T	MLL	ALL								4	113					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26094758	26094758	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr17:26094758C>T	ENST00000313735.6	-	18	2373	c.2140G>A	c.(2140-2142)Gac>Aac	p.D714N		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	714					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GGCTGTGAGTCCTGCACGAGC	0.557000													8	65					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50682700	50682700	+	Silent	SNP	T	T	C			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr22:50682700T>C	ENST00000439308.2	-	1	681	c.189A>G	c.(187-189)aaA>aaG	p.K63K	TUBGCP6_ENST00000248846.5_Silent_p.K63K	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	63					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TCGCTGGTAGTTTTGACATGT	0.522000													14	165					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99413924	99413924	+	Silent	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr2:99413924C>T	ENST00000397899.2	-	8	2824	c.2493G>A	c.(2491-2493)cgG>cgA	p.R831R		NM_207362.2	NP_997245.2			KIAA1211-like									p.R831R(1)									TCCGCTTCTGCCGAGTGACGG	0.612000													5	205					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176310790	176310790	+	Silent	SNP	G	G	A	rs140261586	byFrequency	TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr5:176310790G>A	ENST00000292432.5	-	15	2125	c.2034C>T	c.(2032-2034)tgC>tgT	p.C678C		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	678	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCCTATCTCGCAACGGGGGT	0.547000													6	142					0	0	1	0	0
ZNF789	285989	broad.mit.edu	37	7	99084225	99084225	+	Missense_Mutation	SNP	A	A	C			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr7:99084225A>C	ENST00000331410.5	+	5	662	c.392A>C	c.(391-393)aAg>aCg	p.K131T	ZNF789_ENST00000448667.1_3'UTR|ZNF789_ENST00000494186.1_Intron|ZNF789_ENST00000493485.1_Intron	NM_213603.2	NP_998768.2	Q5FWF6	ZN789_HUMAN	zinc finger protein 789	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)	11	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					AAGTTACATAAGTGTAAAGAA	0.368000													25	161					0	0	1	0	0
CD1D	912	broad.mit.edu	37	1	158151489	158151489	+	Silent	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr1:158151489C>T	ENST00000368171.3	+	3	805	c.306C>T	c.(304-306)ttC>ttT	p.F102F		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	102					antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					TGAAGGAATTCGCCAAAATGC	0.557000													9	133					0	0	1	0	0
FBXO42	54455	broad.mit.edu	37	1	16577790	16577790	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr1:16577790G>A	ENST00000375592.3	-	10	1745	c.1529C>T	c.(1528-1530)tCc>tTc	p.S510F		NM_018994.1	NP_061867.1	Q6P3S6	FBX42_HUMAN	F-box protein 42	510										autonomic_ganglia(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	26		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		ATTACTACTGGAAGCGGGTTT	0.483000													17	161					0	0	1	0	0
TNK1	8711	broad.mit.edu	37	17	7286330	7286330	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr17:7286330G>A	ENST00000570896.1	+	3	531	c.85G>A	c.(85-87)Gag>Aag	p.E29K	TNK1_ENST00000576812.1_Missense_Mutation_p.E29K|TNK1_ENST00000311668.2_Missense_Mutation_p.E29K			Q13470	TNK1_HUMAN	tyrosine kinase, non-receptor, 1	29					protein autophosphorylation	membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(2)|pancreas(1)	16		Prostate(122;0.157)				CATCCTTGAGGAGCTTAATGT	0.597000													6	100					0	0	1	0	0
IGHA1	0	broad.mit.edu	37	14	106173748	106173748	+	RNA	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr14:106173748G>A	ENST00000390547.2	-	0	818																											GGTACTTCTCGCGGGGCAGCT	0.662000													16	153					0	0	1	0	0
PAX9	5083	broad.mit.edu	37	14	37132662	37132662	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr14:37132662C>T	ENST00000361487.6	+	2	790	c.565C>T	c.(565-567)Ccg>Tcg	p.P189S	PAX9_ENST00000554201.1_Missense_Mutation_p.P2S|PAX9_ENST00000402703.2_Missense_Mutation_p.P189S			P55771	PAX9_HUMAN	paired box 9	189	Interaction with KDM5B.				multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(3)	12	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)		GGTGGCCATGCCGCGCACCTG	0.682000													4	117					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													4	95					0	0	1	0	0
TRA2A	29896	broad.mit.edu	37	7	23561395	23561395	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr7:23561395G>A	ENST00000297071.4	-	2	317	c.101C>T	c.(100-102)tCa>tTa	p.S34L	TRA2A_ENST00000392502.4_5'UTR|TRA2A_ENST00000538367.1_5'UTR|TRA2A_ENST00000474586.1_5'UTR	NM_013293.3	NP_037425.1	Q13595	TRA2A_HUMAN	transformer 2 alpha homolog (Drosophila)	34	Arg/Ser-rich (RS1 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	10						ACGAGATCCTGACCTGCTCTC	0.418000													4	140					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642000													5	140					0	0	1	0	0
NUP160	23279	broad.mit.edu	37	11	47857211	47857211	+	Nonsense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr11:47857211G>A	ENST00000378460.2	-	7	1139	c.1093C>T	c.(1093-1095)Cga>Tga	p.R365*	NUP160_ENST00000528071.1_Nonsense_Mutation_p.R251*|NUP160_ENST00000530326.1_Nonsense_Mutation_p.R251*	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa	365					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						ACCTGTCCTCGTTTTGGTGCA	0.448000													10	122					0	0	1	0	0
OR5AU1	390445	broad.mit.edu	37	14	21623156	21623156	+	Silent	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr14:21623156C>T	ENST00000304418.3	-	1	1066	c.1029G>A	c.(1027-1029)ttG>ttA	p.L343L		NM_001004731.1	NP_001004731.1	Q8NGC0	O5AU1_HUMAN	olfactory receptor, family 5, subfamily AU, member 1	343					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(12)|pancreas(1)	21	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		CCTTGTTTCTCAAAGAGTACA	0.463000													19	133					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128671	45128671	+	RNA	SNP	T	T	G	rs1056072	by1000genomes	TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr17:45128671T>G	ENST00000575173.1	-	0	418																											GCTCACAAAATAAGTTCCAGG	0.323000													4	141					0	0	1	0	0
TRBV5-4	0	broad.mit.edu	37	7	142168862	142168862	+	RNA	SNP	A	A	G	rs140095394	by1000genomes	TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr7:142168862A>G	ENST00000454561.2	-	0	183																											TGGGCCAGGCAGCACTGCACC	0.597000													4	41					0	0	1	0	0
ZNF417	147687	broad.mit.edu	37	19	58423500	58423500	+	Missense_Mutation	SNP	G	G	C			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr19:58423500G>C	ENST00000312026.5	-	2	255	c.91C>G	c.(91-93)Ctt>Gtt	p.L31V	CTD-2583A14.9_ENST00000602124.1_5'UTR|ZNF417_ENST00000595559.1_Missense_Mutation_p.L30V|ZNF417_ENST00000536263.1_5'UTR	NM_152475.2	NP_689688.2	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	31	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|stomach(3)|upper_aerodigestive_tract(1)	18		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		TCACTAAGAAGACACCACTCC	0.507000													9	212					0	0	1	0	0
D86994.2	0	broad.mit.edu	37	22	23006960	23006960	+	RNA	SNP	C	C	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr22:23006960C>A	ENST00000385099.1	+	0	63																											GGGCTCTGCTCCTCCTCACCC	0.627000													4	18					2.56e-06	2.76317e-06	1	1	0
FRG1B	0	broad.mit.edu	37	20	29628283	29628283	+	Silent	SNP	G	G	C			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr20:29628283G>C	ENST00000278882.3	+	6	665	c.285G>C	c.(283-285)ggG>ggC	p.G95G	FRG1B_ENST00000358464.4_Silent_p.G95G|FRG1B_ENST00000439954.2_Silent_p.G100G														p.G95G(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGAAGCAGGGGACATAGAAG	0.378000													5	232					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71649963	71649963	+	Missense_Mutation	SNP	C	C	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr2:71649963C>A	ENST00000409544.1	+	22	3949	c.3319C>A	c.(3319-3321)Cca>Aca	p.P1107T	ZNF638_ENST00000355812.3_Intron|ZNF638_ENST00000264447.4_Missense_Mutation_p.P1107T|ZNF638_ENST00000409407.1_Missense_Mutation_p.P47T	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	1107	Glu-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						GAAAAACAGTCCAATTGATGA	0.338000													4	124					0.217242	0.217242	1	1	0
PDHA2	5161	broad.mit.edu	37	4	96762205	96762205	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr4:96762205C>T	ENST00000295266.4	+	1	967	c.904C>T	c.(904-906)Cga>Tga	p.R302*		NM_005390.4	NP_005381.1	P29803	ODPAT_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 2	302					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(23)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	46		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	TTATCGTACACGAGAAGAAAT	0.423000													15	136					0	0	1	0	0
ANKRD20A8P	0	broad.mit.edu	37	2	95522772	95522772	+	RNA	SNP	T	T	C			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr2:95522772T>C	ENST00000432432.2	-	0	255					NR_040113.1													p.E49G(1)									GCGCTCCACCTCCGCGGCGTC	0.682000													4	115					0	0	1	0	0
D86994.2	0	broad.mit.edu	37	22	23006961	23006961	+	RNA	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr22:23006961C>T	ENST00000385099.1	+	0	64																											GGCTCTGCTCCTCCTCACCCT	0.627000													4	19					0	0	1	0	0
ZBTB48	3104	broad.mit.edu	37	1	6649154	6649154	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr1:6649154G>A	ENST00000377674.4	+	11	2107	c.1949G>A	c.(1948-1950)gGc>gAc	p.G650D		NM_001278647.1|NM_001278648.1|NM_005341.2	NP_001265576.1|NP_001265577.1|NP_005332.1	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48	650						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		GCCCAGGGCGGCCTGGCCTCC	0.672000													5	175					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593025	96593025	+	Missense_Mutation	SNP	C	C	T	rs75189823	by1000genomes	TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr2:96593025C>T	ENST00000456556.1	-	28	1960	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N						ankyrin repeat domain 36C									p.D626N(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCTTTCTCATCACTTGTAGCC	0.318000													4	100					0	0	1	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76074470	76074470	+	RNA	SNP	A	A	G			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr15:76074470A>G	ENST00000395215.3	+	0	649																		p.Q203R(4)									CGGTTACAGCAGACCATAAAG	0.577000													4	19					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38958369	38958369	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr19:38958369C>T	ENST00000355481.4	+	25	3429	c.3298C>T	c.(3298-3300)Cgc>Tgc	p.R1100C	RYR1_ENST00000359596.3_Missense_Mutation_p.R1100C|RYR1_ENST00000360985.3_Missense_Mutation_p.R1100C	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1100	6 X approximate repeats.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGGCGAGATGCGCGTGGGCTG	0.622000													5	191					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45645337	45645337	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr5:45645337G>A	ENST00000303230.4	-	2	856	c.799C>T	c.(799-801)Cgt>Tgt	p.R267C		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	267						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CGTAATAAACGCAAGAGACTG	0.313000													7	52					0	0	1	0	0
LRRC27	80313	broad.mit.edu	37	10	134158049	134158049	+	Nonsense_Mutation	SNP	G	G	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr10:134158049G>T	ENST00000392638.2	+	5	643	c.448G>T	c.(448-450)Gaa>Taa	p.E150*	LRRC27_ENST00000368615.3_Nonsense_Mutation_p.E150*|LRRC27_ENST00000368614.3_Nonsense_Mutation_p.E150*|LRRC27_ENST00000368612.1_Nonsense_Mutation_p.E88*|LRRC27_ENST00000344079.5_Nonsense_Mutation_p.E150*|LRRC27_ENST00000432555.2_Nonsense_Mutation_p.E23*|LRRC27_ENST00000368613.4_Nonsense_Mutation_p.E150*|LRRC27_ENST00000368610.3_Nonsense_Mutation_p.E88*|LRRC27_ENST00000356571.4_Missense_Mutation_p.G130V			Q9C0I9	LRC27_HUMAN	leucine rich repeat containing 27	150										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)	18		all_cancers(35;6.28e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;9.12e-05)|Epithelial(32;0.000116)|all cancers(32;0.000145)|BRCA - Breast invasive adenocarcinoma(275;0.218)		CTGCCCTCTGGAATTCCCTCC	0.498000													12	189					3.07112e-06	3.26306e-06	1	1	0
FAM124A	220108	broad.mit.edu	37	13	51825914	51825914	+	Silent	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr13:51825914C>T	ENST00000322475.8	+	3	546	c.411C>T	c.(409-411)caC>caT	p.H137H	FAM124A_ENST00000280057.6_Silent_p.H173H	NM_001242312.1	NP_001229241.1	Q86V42	F124A_HUMAN	family with sequence similarity 124A	137										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|skin(1)	26		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		AGCAGGTGCACGGCCGGTTCC	0.672000													4	16					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9243051	9243051	+	Missense_Mutation	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr12:9243051C>T	ENST00000318602.7	-	20	2804	c.2497G>A	c.(2497-2499)Gcc>Acc	p.A833T		NM_000014.4	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin	833					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	GCTAGGAAGGCGGGAGAGGCT	0.532000													12	137					0	0	1	0	0
SAMD1	90378	broad.mit.edu	37	19	14199510	14199510	+	Silent	SNP	C	C	T			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr19:14199510C>T	ENST00000533683.2	-	4	1400	c.1113G>A	c.(1111-1113)ccG>ccA	p.P371P		NM_138352.1	NP_612361	Q6SPF0	SAMD1_HUMAN	sterile alpha motif domain containing 1	477						cytoplasm|extracellular region				endometrium(3)	3		Renal(1328;0.00183)|Hepatocellular(1079;0.00826)		GBM - Glioblastoma multiforme(1328;0.000411)|STAD - Stomach adenocarcinoma(1328;0.00644)|Lung(535;0.199)		TCGCCTGCTCCGGGAATCCAG	0.567000													4	89					0	0	1	0	0
RP11-556I14.1	0	broad.mit.edu	37	4	105918247	105918247	+	RNA	DEL	T	T	-	rs140898060		TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr4:105918247delT	ENST00000506386.1	+	0	71																											ttttttttccttttttttttt	0.318													3	3	---	---	---	---					
CELP	0	broad.mit.edu	37	9	135962465	135962465	+	RNA	DEL	T	T	-	rs63239560		TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr9:135962465delT	ENST00000411440.2	+	0	972					NR_001275.2																						AGGATGCCCCTGTGCCCCTCA	0.677													3	5	---	---	---	---					
OR56B1	387748	broad.mit.edu	37	11	5758619	5758619	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr11:5758619delC	ENST00000317121.3	+	1	939	c.873delC	c.(871-873)atcfs	p.I291fs	TRIM5_ENST00000380027.1_Intron	NM_001005180.2	NP_001005180.1	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B, member 1	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		ACAACATCATCCCCCCTTCCC	0.403													7	585	---	---	---	---					
FOXN3	1112	broad.mit.edu	37	14	89629149	89629151	+	In_Frame_Del	DEL	GAG	GAG	-	rs139532153		TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr14:89629149_89629151delGAG	ENST00000345097.4	-	7	1196_1198	c.1080_1082delCTC	c.(1078-1083)tcctca>tca	p.360_361SS>S	FOXN3_ENST00000261302.5_In_Frame_Del_p.360_361SS>S|FOXN3_ENST00000555353.1_In_Frame_Del_p.338_339SS>S|FOXN3_ENST00000557258.1_In_Frame_Del_p.338_339SS>S	NM_001085471.1	NP_001078940.1	O00409	FOXN3_HUMAN	forkhead box N3	360					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GTCGTCGGCTGAGGAGGAGGAGG	0.650													7	84	---	---	---	---					
MT4	84560	broad.mit.edu	37	16	56602769	56602769	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr16:56602769delC	ENST00000219162.3	+	3	194	c.114delC	c.(112-114)tgcfs	p.C38fs		NM_032935.2	NP_116324	P47944	MT4_HUMAN	metallothionein 4	38						cytoplasm	copper ion binding|zinc ion binding			ovary(1)|upper_aerodigestive_tract(1)	2						GTCCCTGCTGCCCCCCGGGCT	0.597													8	485	---	---	---	---					
ANKRD24	170961	broad.mit.edu	37	19	4217746	4217746	+	Frame_Shift_Del	DEL	G	G	-			TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr19:4217746delG	ENST00000600132.1	+	18	2865	c.2589delG	c.(2587-2589)acgfs	p.T863fs	ANKRD24_ENST00000318934.4_Frame_Shift_Del_p.T863fs|ANKRD24_ENST00000262970.5_Frame_Shift_Del_p.T953fs	NM_133475.1	NP_597732.1	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	863										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		CCAGGGCCACGGGGGAGCAGC	0.791													2	4	---	---	---	---					
FRG1B	0	broad.mit.edu	37	20	29628310	29628312	+	In_Frame_Del	DEL	AGG	AGG	-	rs111939959		TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr20:29628310_29628312delAGG	ENST00000278882.3	+	6	692_694	c.312_314delAGG	c.(310-315)gcagga>gca	p.G105del	FRG1B_ENST00000358464.4_In_Frame_Del_p.G105del|FRG1B_ENST00000439954.2_In_Frame_Del_p.G110del																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTAAAACAGCAGGAGAAGAAGAA	0.355													7	218	---	---	---	---					
RP5-1043L13.1	0	broad.mit.edu	37	20	58883399	58883400	+	RNA	INS	-	-	T	rs149794923	by1000genomes	TCGA-J4-A67R-01A-21D-A30E-08	TCGA-J4-A67R-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df8a2b1-72de-4a9c-a20d-f659cefe1ed4	ecef180f-ebad-4421-8489-69ff5a12d716	g.chr20:58883399_58883400insT	ENST00000432910.1	+	0	332					NR_046099.1																						ggaccgggaaacagatgcttac	0.569													5	6	---	---	---	---					
