Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PTPDC1	138639	broad.mit.edu	37	9	96860386	96860386	+	Nonsense_Mutation	SNP	C	C	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr9:96860386C>G	ENST00000375360.3	+	7	1716	c.1376C>G	c.(1375-1377)tCa>tGa	p.S459*	PTPDC1_ENST00000288976.3_Nonsense_Mutation_p.S511*	NM_001253830.1|NM_177995.2	NP_001240759.1|NP_818931.1	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	459							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	32						TGGAGTCAGTCAAAGTTTGGA	0.473000													7	29					0	0	1	0	0
USP11	8237	broad.mit.edu	37	X	47099251	47099251	+	Silent	SNP	G	G	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chrX:47099251G>A	ENST00000377107.2	+	4	834	c.480G>A	c.(478-480)cgG>cgA	p.R160R	USP11_ENST00000218348.3_Silent_p.R203R			P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	203	DUSP.			A -> R (in Ref. 3; BAC20463).	protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|ovary(3)|pancreas(1)|stomach(1)	40						TGCTTGTCCGGCACAATGATT	0.498000													3	46					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197008543	197008543	+	Splice_Site	SNP	T	T	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr1:197008543T>A	ENST00000367412.1	-	12	1996		c.e12-2			NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide						blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						GACAGAGTGCTTGAGGGGAAA	0.303000													4	151					0	0	1	0	0
TRIM49C	642612	broad.mit.edu	37	11	89774252	89774252	+	Missense_Mutation	SNP	G	G	A	rs145791878	by1000genomes	TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr11:89774252G>A	ENST00000448984.1	+	8	1222	c.893G>A	c.(892-894)aGt>aAt	p.S298N	TRIM49C_ENST00000432771.1_Intron	NM_001195234.1	NP_001182163.1	P0CI26	T49L2_HUMAN	tripartite motif containing 49C	298	B30.2/SPRY.					intracellular	zinc ion binding	p.S298N(4)		endometrium(3)|kidney(1)|lung(4)	8						GAAGCCAACAGTGATATCTTT	0.323000													4	37					0	0	1	0	0
PPAP2A	8611	broad.mit.edu	37	5	54786858	54786858	+	Missense_Mutation	SNP	T	T	C			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr5:54786858T>C	ENST00000264775.5	-	2	482	c.143A>G	c.(142-144)tAt>tGt	p.Y48C	PPAP2A_ENST00000515132.1_Intron|PPAP2A_ENST00000307259.8_Intron	NM_176895.1	NP_795714.1	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A	47					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			breast(2)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)	9		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				ATGGTACGGATAGTTGATGCT	0.443000													3	38					0	0	1	0	0
CHAF1A	10036	broad.mit.edu	37	19	4433394	4433394	+	Missense_Mutation	SNP	C	C	T	rs139033845		TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr19:4433394C>T	ENST00000301280.5	+	13	2632	c.2531C>T	c.(2530-2532)tCg>tTg	p.S844L		NM_005483.2	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	844	Binds to p60.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		TATGTGACATCGGTGCCCTCG	0.657000								Chromatin Structure					26	39					0	0	1	0	0
ENTPD4	9583	broad.mit.edu	37	8	23301996	23301996	+	Missense_Mutation	SNP	G	G	T			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr8:23301996G>T	ENST00000358689.4	-	5	771	c.536C>A	c.(535-537)aCg>aAg	p.T179K	ENTPD4_ENST00000417069.2_Missense_Mutation_p.T179K|ENTPD4_ENST00000356206.6_Missense_Mutation_p.T179K	NM_001128930.2|NM_004901.4	NP_001122402.1|NP_004892.1	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	179					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	25		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		CATTCCAGCCGTGCAGAGAAT	0.532000													17	15					2.94398e-08	2.98665e-08	1	1	0
TIMD4	91937	broad.mit.edu	37	5	156381616	156381616	+	Silent	SNP	G	G	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr5:156381616G>A	ENST00000274532.2	-	2	266	c.210C>T	c.(208-210)cgC>cgT	p.R70R	TIMD4_ENST00000407087.3_Silent_p.R70R	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	70	Ig-like V-type.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTCCATCAGTGCGGATGAGCG	0.527000													14	32					0	0	1	0	0
BEND7	222389	broad.mit.edu	37	10	13489309	13489309	+	Silent	SNP	C	C	T			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr10:13489309C>T	ENST00000341083.3	-	8	1334	c.1038G>A	c.(1036-1038)gcG>gcA	p.A346A	BEND7_ENST00000378605.3_Silent_p.A358A|BEND7_ENST00000486542.1_5'UTR|BEND7_ENST00000396900.2_Silent_p.A397A|BEND7_ENST00000396898.2_Silent_p.A410A	NM_152751.2	NP_689964.2	Q8N7W2	BEND7_HUMAN	BEN domain containing 7	397	BEN.						protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|stomach(1)	17						CATCACTGTCCGCGATCTCTG	0.388000													32	62					0	0	1	0	0
AKT2	208	broad.mit.edu	37	19	40745988	40745988	+	Silent	SNP	G	G	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr19:40745988G>A	ENST00000392038.2	-	7	901	c.603C>T	c.(601-603)agC>agT	p.S201S	AKT2_ENST00000311278.6_Silent_p.S201S|AKT2_ENST00000579047.1_Silent_p.S139S|AKT2_ENST00000424901.1_Silent_p.S201S	NM_001243027.1|NM_001243028.1|NM_001626.4	NP_001229956.1|NP_001229957.1|NP_001617.1	P31751	AKT2_HUMAN	v-akt murine thymoma viral oncogene homolog 2	201	Protein kinase.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|kidney(3)|large_intestine(9)|lung(10)|prostate(2)|skin(1)	27			Lung(22;0.000499)			GGAGGACCCGGCTCTCGGTGA	0.632000			A		"""ovarian, pancreatic """								7	169					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66502033	66502033	+	Silent	SNP	T	T	C			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr3:66502033T>C	ENST00000383703.3	-	3	918	c.315A>G	c.(313-315)acA>acG	p.T105T	LRIG1_ENST00000273261.3_Silent_p.T105T			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	105						integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		ATGGTACCGCTGTCAACTCAT	0.443000													41	50					0	0	1	0	0
TRAV26-1	0	broad.mit.edu	37	14	22592021	22592021	+	RNA	SNP	A	A	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr14:22592021A>G	ENST00000390455.3	+	0	315																											AAGAGCTGCAAACCTGCCTTG	0.458000													14	78					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36261976	36261976	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr6:36261976G>A	ENST00000394571.2	+	4	514	c.514G>A	c.(514-516)Gat>Aat	p.D172N	PNPLA1_ENST00000388715.3_Missense_Mutation_p.D77N|PNPLA1_ENST00000312917.5_Missense_Mutation_p.D86N	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	172	Patatin.				lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						GAGGTACATCGATGGGGGCTT	0.617000													20	29					0	0	1	0	0
DPYSL4	10570	broad.mit.edu	37	10	134016313	134016313	+	Missense_Mutation	SNP	T	T	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr10:134016313T>G	ENST00000338492.4	+	12	1609	c.1445T>G	c.(1444-1446)aTc>aGc	p.I482S	DPYSL4_ENST00000368629.1_Intron|DPYSL4_ENST00000368627.1_Intron	NM_006426.2	NP_006417.2	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	482					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		TACAAGAGGATCAAAGCTCGC	0.632000													22	45					0	0	1	0	0
POM121L9P	0	broad.mit.edu	37	22	24659593	24659593	+	RNA	SNP	C	C	T			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr22:24659593C>T	ENST00000414583.2	+	0	3118					NR_003714.1																						TCACTGACATCGAAGGCTGCC	0.632000													4	22					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	161030498	161030498	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr2:161030498G>A	ENST00000283249.2	-	5	983	c.746C>T	c.(745-747)gCt>gTt	p.A249V	ITGB6_ENST00000409872.1_Missense_Mutation_p.A249V|ITGB6_ENST00000485635.1_5'UTR|ITGB6_ENST00000428609.2_Missense_Mutation_p.A207V|ITGB6_ENST00000409967.2_Missense_Mutation_p.A249V	NM_001282353.1|NM_001282354.1|NM_001282388.1	NP_001269282.1|NP_001269283.1|NP_001269317.1	P18564	ITB6_HUMAN	integrin, beta 6	249	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						ACACACAGCAGCTTGCATAAT	0.333000													8	50					0	0	1	0	0
SPAG6	9576	broad.mit.edu	37	10	22657474	22657474	+	Missense_Mutation	SNP	T	T	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr10:22657474T>G	ENST00000376603.2	+	4	709	c.567T>G	c.(565-567)caT>caG	p.H189Q	SPAG6_ENST00000313311.6_Missense_Mutation_p.H113Q|RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000538630.1_Missense_Mutation_p.H88Q|SPAG6_ENST00000376601.1_Intron|SPAG6_ENST00000376624.3_Missense_Mutation_p.H113Q			O75602	SPAG6_HUMAN	sperm associated antigen 6	113					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						TTGGTAAACATTCTCCCCAGC	0.458000													30	42					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51383369	51383369	+	Silent	SNP	G	G	C			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr14:51383369G>C	ENST00000216392.7	-	9	1415	c.1083C>G	c.(1081-1083)ccC>ccG	p.P361P	PYGL_ENST00000544180.2_Silent_p.P327P|PYGL_ENST00000532462.1_Silent_p.P361P	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	361					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	CCTTGGACCAGGGCAGTTTTT	0.453000													11	32					0	0	1	0	0
POM121L9P	0	broad.mit.edu	37	22	24659591	24659591	+	RNA	SNP	A	A	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr22:24659591A>G	ENST00000414583.2	+	0	3116					NR_003714.1																						ACTCACTGACATCGAAGGCTG	0.632000													4	23					0	0	1	0	0
OVCH1	341350	broad.mit.edu	37	12	29649132	29649132	+	Missense_Mutation	SNP	C	C	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr12:29649132C>A	ENST00000318184.5	-	3	262	c.263G>T	c.(262-264)tGc>tTc	p.C88F		NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	88	Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GCTGTCCAGGCAGTGTGCTGC	0.463000													3	2					0.00024832	0.00024832	1	1	0
SIRPB1	10326	broad.mit.edu	37	20	1592193	1592193	+	Silent	SNP	C	C	T			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr20:1592193C>T	ENST00000279477.7	-	2	307	c.243G>A	c.(241-243)caG>caA	p.Q81Q	SIRPB1_ENST00000381603.3_Intron|SIRPB1_ENST00000381596.1_5'UTR|SIRPB1_ENST00000568365.1_Silent_p.Q81Q|SIRPB1_ENST00000381605.4_Intron|RP4-576H24.4_ENST00000564763.1_Intron	NM_001135844.2	NP_001129316.1	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	81	Ig-like V-type.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						GGCCTTCTTTCTGATTGTAGA	0.522000													4	96					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977359	29977359	+	RNA	SNP	G	G	A	rs3831361	by1000genomes	TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr6:29977359G>A	ENST00000376797.3	-	0	731				HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA																							ATTTGTTCATGCCTTCCCTTT	0.453000													11	41					0	0	1	0	0
SYTL1	84958	broad.mit.edu	37	1	27675577	27675577	+	Missense_Mutation	SNP	G	G	C			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr1:27675577G>C	ENST00000543823.1	+	5	928	c.466G>C	c.(466-468)Gat>Cat	p.D156H	SYTL1_ENST00000318074.5_Intron|SYTL1_ENST00000490170.1_3'UTR			Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	156					exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			NS(1)|large_intestine(4)|lung(5)|ovary(1)|urinary_tract(1)	12		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TCAGGGACCTGATTTCCCATC	0.592000													27	39					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237787069	237787069	+	Missense_Mutation	SNP	A	A	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr1:237787069A>G	ENST00000366574.2	+	39	6238	c.5921A>G	c.(5920-5922)aAt>aGt	p.N1974S	RYR2_ENST00000360064.6_Missense_Mutation_p.N1972S|RYR2_ENST00000542537.1_Missense_Mutation_p.N1958S	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1974	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTCAGATCAATATGCTTCTC	0.408000													11	12					0	0	1	0	0
ZNF445	353274	broad.mit.edu	37	3	44488286	44488286	+	Silent	SNP	G	G	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr3:44488286G>A	ENST00000425708.2	-	7	3218	c.2877C>T	c.(2875-2877)tgC>tgT	p.C959C	ZNF445_ENST00000396077.2_Silent_p.C959C			P59923	ZN445_HUMAN	zinc finger protein 445	959					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|skin(3)	31				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		AGCTCTGGCTGCAAGCTTCTT	0.483000													4	98					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7576851	7576851	+	Splice_Site	SNP	A	A	C			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr17:7576851A>C	ENST00000420246.2	-	9	1126		c.e9+1		TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000359597.4_Splice_Site|TP53_ENST00000413465.2_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(12)|p.0?(8)|p.I332fs*49(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AAGACTTAGTACCTGAAGGGT	0.463000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	13					0	0	1	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276861	71276861	+	Silent	SNP	T	T	C	rs36179995		TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr11:71276861T>C	ENST00000398531.1	+	1	253	c.228T>C	c.(226-228)tcT>tcC	p.S76S	KRTAP5-10_ENST00000376536.4_Intron	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	76	7 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						ACTGTGGCTCTTGTGGGGGCT	0.677000													5	232					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977358	29977358	+	RNA	SNP	T	T	C	rs146982767	by1000genomes	TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr6:29977358T>C	ENST00000376797.3	-	0	731				HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA																							GATTTGTTCATGCCTTCCCTT	0.448000													11	43					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11098827	11098827	+	RNA	SNP	C	C	T	rs79274499	by1000genomes	TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr21:11098827C>T	ENST00000470054.1	-	0	98									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ccatccagagcgagacgagcc	0.637000													6	47					0	0	1	0	0
PCDHB1	0	broad.mit.edu	37	5	140431178	140431178	+	Silent	SNP	C	C	T			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr5:140431178C>T	ENST00000306549.3	+	1	200	c.123C>T	c.(121-123)agC>agT	p.S41S		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		41	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATGGAGAGCGGCTCGTTTG	0.542000													8	28					0	0	1	0	0
RBM14	10432	broad.mit.edu	37	11	66392698	66392698	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr11:66392698G>A	ENST00000310137.4	+	2	1490	c.1351G>A	c.(1351-1353)Gca>Aca	p.A451T	RBM14_ENST00000409738.4_Intron|RBM14-RBM4_ENST00000412278.2_Intron|RBM4_ENST00000503028.2_Intron|RBM14_ENST00000393979.3_Intron|RBM14-RBM4_ENST00000500635.2_Intron|RBM4_ENST00000514361.3_Intron|RBM14-RBM4_ENST00000511114.1_Intron	NM_006328.3	NP_006319.1	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	451	Ala-rich.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity		RBM14/PACS1(2)	breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						AGCCTACGCCGCACAAGCCAC	0.617000													4	203					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164272621	164272621	+	Missense_Mutation	SNP	C	C	T			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr4:164272621C>T	ENST00000515560.1	+	4	2718	c.1196C>T	c.(1195-1197)tCa>tTa	p.S399L	NPY5R_ENST00000506953.1_Missense_Mutation_p.S399L|NPY5R_ENST00000338566.3_Missense_Mutation_p.S399L			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	399					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				AATCTTATTTCAAATAGGCAT	0.343000													12	64					0	0	1	0	0
ECD	11319	broad.mit.edu	37	10	74916082	74916082	+	Missense_Mutation	SNP	T	T	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr10:74916082T>G	ENST00000372979.4	-	5	747	c.541A>C	c.(541-543)Ata>Cta	p.I181L	ECD_ENST00000454759.2_Missense_Mutation_p.I181L|ECD_ENST00000430082.2_Missense_Mutation_p.I181L	NM_007265.2	NP_009196.1	O95905	SGT1_HUMAN	ecdysoneless homolog (Drosophila)	181					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(51;0.0119)					GAAGCAAGTATTTTTTCTGAA	0.403000													11	72					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211476889	211476889	+	Missense_Mutation	SNP	C	C	T			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr2:211476889C>T	ENST00000233072.5	+	20	2636	c.2440C>T	c.(2440-2442)Cgg>Tgg	p.R814W	CPS1_ENST00000430249.2_Missense_Mutation_p.R820W|CPS1_ENST00000451903.2_Missense_Mutation_p.R363W	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	814					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GAAAGCTTTACGGATGTGCCA	0.398000													11	113					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								4	64					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207758094	207758094	+	Missense_Mutation	SNP	C	C	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr1:207758094C>A	ENST00000367049.4	+	33	5403	c.5403C>A	c.(5401-5403)gaC>gaA	p.D1801E	CR1_ENST00000367052.1_Missense_Mutation_p.D1351E|RP11-78B10.2_ENST00000596003.1_RNA|CR1_ENST00000367051.1_Missense_Mutation_p.D1351E|RP11-78B10.2_ENST00000597497.1_RNA|CR1_ENST00000367053.1_Missense_Mutation_p.D1351E|CR1_ENST00000400960.2_Missense_Mutation_p.D1351E	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1351	Sushi 28.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						ACACATGTGACCCCCACCCAG	0.507000													40	58					2.05212e-20	2.17649e-20	1	1	0
GPX7	2882	broad.mit.edu	37	1	53072580	53072580	+	Silent	SNP	C	C	T			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr1:53072580C>T	ENST00000361314.4	+	2	401	c.363C>T	c.(361-363)acC>acT	p.T121T	GPX7_ENST00000459779.1_3'UTR	NM_015696.4	NP_056511.2	Q96SL4	GPX7_HUMAN	glutathione peroxidase 7	121					response to oxidative stress	extracellular region	glutathione peroxidase activity			breast(1)|kidney(1)|lung(4)|upper_aerodigestive_tract(1)	7					Glutathione(DB00143)	TTGCAGTCACCGGTACTGGTG	0.567000													9	120					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72131766	72131766	+	Nonsense_Mutation	SNP	G	G	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr9:72131766G>A	ENST00000265381.4	-	2	583	c.361C>T	c.(361-363)Cag>Tag	p.Q121*		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	121					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						GGCCGGTACTGCACAGCATAG	0.731000													11	11					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64968481	64968481	+	Missense_Mutation	SNP	C	C	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr10:64968481C>G	ENST00000399262.2	-	10	3166	c.2948G>C	c.(2947-2949)aGg>aCg	p.R983T	JMJD1C_ENST00000399251.1_Missense_Mutation_p.R764T|JMJD1C_ENST00000542921.1_Missense_Mutation_p.R801T|JMJD1C_ENST00000402544.1_Missense_Mutation_p.R764T	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	983					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					AGTCTGTGACCTATTTAGATC	0.393000													33	45					0	0	1	0	0
SRGAP2	23380	broad.mit.edu	37	1	206610382	206610382	+	Silent	SNP	C	C	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr1:206610382C>G	ENST00000414007.1	+	11	1203	c.1203C>G	c.(1201-1203)gcC>gcG	p.A401A	SRGAP2_ENST00000419187.2_5'UTR			O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	541					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(1)|breast(1)|kidney(1)|lung(1)	4	Breast(84;0.137)					TCAAAAATGCCTTTGAGAGAG	0.453000													6	93					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39003004	39003004	+	Missense_Mutation	SNP	C	C	T	rs2915960	byFrequency	TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr19:39003004C>T	ENST00000355481.4	+	63	9484	c.9353C>T	c.(9352-9354)gCg>gTg	p.A3118V	RYR1_ENST00000360985.3_Missense_Mutation_p.A3118V|RYR1_ENST00000359596.3_Missense_Mutation_p.A3118V	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3118			A -> V (in dbSNP:rs2915960).		muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GTGTCGCAGGCGCGCACCCAG	0.637000													7	36					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160771695	160771695	+	Silent	SNP	G	G	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr1:160771695G>A	ENST00000368039.2	+	3	571	c.570G>A	c.(568-570)gtG>gtA	p.V190V	LY9_ENST00000368037.5_Intron|LY9_ENST00000392203.4_Intron|LY9_ENST00000368041.2_Intron|LY9_ENST00000263285.6_Intron|LY9_ENST00000368040.1_Intron|LY9_ENST00000471816.1_Intron|LY9_ENST00000341032.4_Intron	NM_001033667.2	NP_001028839.1	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	0	Ig-like C2-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GTGTGAGCGTGCGGGAGGGCT	0.687000													10	79					0	0	1	0	0
SFRP2	6423	broad.mit.edu	37	4	154709764	154709764	+	Missense_Mutation	SNP	T	T	C			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr4:154709764T>C	ENST00000274063.4	-	1	508	c.224A>G	c.(223-225)cAg>cGg	p.Q75R		NM_003013.2	NP_003004.1	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2	75	FZ.				brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	16	all_hematologic(180;0.093)	Renal(120;0.117)				AGCGCCGGCCTGCTCCAGCAC	0.632000													21	75					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11098920	11098920	+	RNA	SNP	A	A	G	rs78230864		TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr21:11098920A>G	ENST00000470054.1	-	0	5									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gggagataccagagaccctaa	0.572000													3	12					0	0	1	0	0
MEIS2	4212	broad.mit.edu	37	15	37388558	37388558	+	Missense_Mutation	SNP	C	C	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr15:37388558C>G	ENST00000338564.5	-	4	765	c.319G>C	c.(319-321)Gga>Cga	p.G107R	MEIS2_ENST00000561208.1_Missense_Mutation_p.G107R|MEIS2_ENST00000444725.1_Missense_Mutation_p.G107R|MEIS2_ENST00000397620.2_Missense_Mutation_p.G19R|MEIS2_ENST00000219869.9_Intron|MEIS2_ENST00000557796.2_Missense_Mutation_p.G94R|MEIS2_ENST00000382766.2_Missense_Mutation_p.G107R|MEIS2_ENST00000397624.3_Missense_Mutation_p.G19R|MEIS2_ENST00000424352.2_Missense_Mutation_p.G107R|MEIS2_ENST00000559085.1_Missense_Mutation_p.G94R|MEIS2_ENST00000559561.1_Missense_Mutation_p.G107R|MEIS2_ENST00000340545.5_Missense_Mutation_p.G94R	NM_001220482.1	NP_001207411.1	O14770	MEIS2_HUMAN	Meis homeobox 2	107					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	36		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		CCAGCCACTCCAGGTTCCCGG	0.612000													8	33					0	0	1	0	0
SPDEF	25803	broad.mit.edu	37	6	34506164	34506164	+	Missense_Mutation	SNP	C	C	T	rs145642998	byFrequency	TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr6:34506164C>T	ENST00000374037.3	-	6	1309	c.895G>A	c.(895-897)Gcc>Acc	p.A299T	SPDEF_ENST00000544425.1_Missense_Mutation_p.A283T	NM_012391.2	NP_036523.1	O95238	SPDEF_HUMAN	SAM pointed domain containing ETS transcription factor	299					negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)	15						TAGTTCATGGCGGGACGGTTC	0.592000													4	167					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11098863	11098863	+	RNA	SNP	A	A	G	rs75318310	by1000genomes	TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr21:11098863A>G	ENST00000470054.1	-	0	62									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ccagcctccaactcccccttc	0.627000													3	15					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39264479	39264479	+	Missense_Mutation	SNP	C	C	T			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr13:39264479C>T	ENST00000280481.7	+	1	3214	c.2998C>T	c.(2998-3000)Cca>Tca	p.P1000S		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1000					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CAATGGCATTCCAGCAGAGCA	0.438000													4	88					0	0	1	0	0
AUTS2	26053	broad.mit.edu	37	7	70228266	70228266	+	Nonsense_Mutation	SNP	C	C	T			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr7:70228266C>T	ENST00000342771.4	+	7	1474	c.1153C>T	c.(1153-1155)Cag>Tag	p.Q385*	AUTS2_ENST00000406775.2_Nonsense_Mutation_p.Q385*	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	385	Ser-rich.									breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CCCCTCTGCTCAGAGCCTCTC	0.612000													21	36					0	0	1	0	0
C1orf159	54991	broad.mit.edu	37	1	1021259	1021259	+	Splice_Site	SNP	T	T	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr1:1021259T>G	ENST00000448924.1	-	8	983	c.552A>C	c.(550-552)aaA>aaC	p.K184N	C1orf159_ENST00000379320.1_Splice_Site_p.K148N|C1orf159_ENST00000437760.1_Splice_Site_p.K148N|C1orf159_ENST00000421241.2_Splice_Site_p.K148N|C1orf159_ENST00000482816.1_5'UTR|C1orf159_ENST00000379339.1_Splice_Site_p.K184N|C1orf159_ENST00000294576.5_Splice_Site_p.K148N|C1orf159_ENST00000379319.1_Splice_Site_p.K148N			Q96HA4	CA159_HUMAN	chromosome 1 open reading frame 159	184						integral to membrane						all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.96e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.77e-22)|Colorectal(212;6.51e-05)|COAD - Colon adenocarcinoma(227;0.000214)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		GGGAGATACCTTTGTTTCTTC	0.612000													4	23					0	0	1	0	0
SSTR4	6754	broad.mit.edu	37	20	23016216	23016216	+	Silent	SNP	G	G	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr20:23016216G>A	ENST00000255008.3	+	1	160	c.96G>A	c.(94-96)gcG>gcA	p.A32A	RP4-753D10.3_ENST00000440921.1_RNA	NM_001052.2	NP_001043.2	P31391	SSR4_HUMAN	somatostatin receptor 4	32					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CGGCGGAGGCGGAGGAGGCGG	0.751000													5	42					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64526848	64526848	+	Missense_Mutation	SNP	C	C	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr3:64526848C>A	ENST00000498707.1	-	36	5786	c.5444G>T	c.(5443-5445)tGt>tTt	p.C1815F	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.C1787F	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1815	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		ATCCTTCCGACATTGGCAGTC	0.453000													36	47					2.91434e-09	3.00005e-09	1	1	0
LRP12	29967	broad.mit.edu	37	8	105509980	105509980	+	Missense_Mutation	SNP	T	T	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr8:105509980T>G	ENST00000276654.5	-	5	908	c.800A>C	c.(799-801)tAt>tCt	p.Y267S	LRP12_ENST00000424843.2_Missense_Mutation_p.Y248S	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	267	CUB 2.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AAAAGTACCATAAAAATATTT	0.403000													17	35					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16962337	16962337	+	Missense_Mutation	SNP	C	C	T			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr19:16962337C>T	ENST00000379803.1	+	6	855	c.841C>T	c.(841-843)Ccc>Tcc	p.P281S	SIN3B_ENST00000596802.1_Missense_Mutation_p.P281S|SIN3B_ENST00000248054.5_Missense_Mutation_p.P281S	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	281					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						CGTGTCTGCACCCGCCAAGGT	0.677000													13	31					0	0	1	0	0
RRN3P2	0	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													7	54					0	0	1	0	0
DNM1P46	0	broad.mit.edu	37	15	100331760	100331760	+	RNA	SNP	G	G	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr15:100331760G>A	ENST00000341853.1	-	0	2431					NR_003260.1																						CCCCACAGGAGATAGAGGAGG	0.627000													12	21					0	0	1	0	0
RAB6C	84084	broad.mit.edu	37	2	130738003	130738003	+	Silent	SNP	A	A	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr2:130738003A>G	ENST00000410061.2	+	1	769	c.315A>G	c.(313-315)acA>acG	p.T105T	AC079776.7_ENST00000412425.1_RNA	NM_032144.2	NP_115520.2	Q9H0N0	RAB6C_HUMAN	RAB6C, member RAS oncogene family	105					protein transport|response to drug|small GTPase mediated signal transduction		GTP binding|GTPase activity			large_intestine(2)|lung(1)|skin(1)|urinary_tract(1)	5	Colorectal(110;0.1)					AGCAAACTACAAAGTGGATTG	0.428000													6	121					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185146622	185146622	+	Missense_Mutation	SNP	C	C	T			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr3:185146622C>T	ENST00000265026.3	+	2	587	c.253C>T	c.(253-255)Ctt>Ttt	p.L85F	MAP3K13_ENST00000535426.1_Intron|MAP3K13_ENST00000446828.1_Intron|MAP3K13_ENST00000443863.1_Intron|MAP3K13_ENST00000424227.1_Missense_Mutation_p.L85F	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	85					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			GAACAGCGTTCTTCAGCTAAG	0.532000													15	22					0	0	1	0	0
POM121L9P	0	broad.mit.edu	37	22	24659578	24659578	+	RNA	SNP	A	A	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr22:24659578A>G	ENST00000414583.2	+	0	3103					NR_003714.1																						TGCGCAGGCCAACACTCACTG	0.617000													4	19					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139151265	139151265	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr8:139151265G>A	ENST00000395297.1	-	18	4035	c.3865C>T	c.(3865-3867)Cgc>Tgc	p.R1289C		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1289								p.R1289G(2)		NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AAACATTTGCGCAAATCAGCA	0.438000										HNSCC(54;0.14)			18	30					0	0	1	0	0
EPT1	85465	broad.mit.edu	37	2	26609300	26609300	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr2:26609300G>A	ENST00000260585.7	+	9	1110	c.991G>A	c.(991-993)Gtc>Atc	p.V331I		NM_033505.2	NP_277040.1	Q9C0D9	EPT1_HUMAN	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)	331					phospholipid biosynthetic process	integral to membrane	ethanolaminephosphotransferase activity|metal ion binding										CTTCTTGGTTGTCTTAGTGGT	0.423000													22	44					0	0	1	0	0
SCN2B	6327	broad.mit.edu	37	11	118037790	118037790	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr11:118037790G>A	ENST00000278947.5	-	4	701	c.460C>T	c.(460-462)Cgg>Tgg	p.R154W		NM_004588.4	NP_004579.1	O60939	SCN2B_HUMAN	sodium channel, voltage-gated, type II, beta subunit	154	Ig-like C2-type.				synaptic transmission	voltage-gated sodium channel complex	voltage-gated sodium channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)	7	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.19e-05)|Epithelial(105;0.00117)		GTGGAGTCCCGCTCAGGGGGC	0.622000													9	26					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76022274	76022274	+	Missense_Mutation	SNP	C	C	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr6:76022274C>A	ENST00000393004.2	-	5	3495	c.3274G>T	c.(3274-3276)Gtc>Ttc	p.V1092F	FILIP1_ENST00000370020.1_Missense_Mutation_p.V993F|FILIP1_ENST00000237172.7_Missense_Mutation_p.V1092F|FILIP1_ENST00000498523.1_5'UTR			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	1092										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						ACTGGTCGGACAGTAATAACT	0.498000													30	79					7.26314e-15	7.58836e-15	1	1	0
SMC2	10592	broad.mit.edu	37	9	106882359	106882359	+	Missense_Mutation	SNP	A	A	G			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr9:106882359A>G	ENST00000286398.7	+	16	2336	c.2048A>G	c.(2047-2049)gAt>gGt	p.D683G	SMC2_ENST00000374787.3_Missense_Mutation_p.D683G|SMC2_ENST00000303219.8_Missense_Mutation_p.D683G|SMC2_ENST00000374793.3_Missense_Mutation_p.D683G	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	683					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						GAACTCAAAGATGTTCAGGAT	0.413000													8	110					0	0	1	0	0
OR6K2	81448	broad.mit.edu	37	1	158669502	158669503	+	Frame_Shift_Ins	INS	-	-	A			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr1:158669502_158669503insA	ENST00000359610.2	-	1	983_984	c.940_941insT	c.(940-942)tccfs	p.S314fs		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	314					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					TGGTCTTACGGAAAAAAATATC	0.371													14	42	---	---	---	---					
ANKRD28	23243	broad.mit.edu	37	3	15731729	15731729	+	Splice_Site	DEL	T	T	-			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr3:15731729delT	ENST00000399451.2	-	18	2039		c.e18-2		ANKRD28_ENST00000383777.1_Splice_Site|ANKRD28_ENST00000497037.1_Splice_Site	NM_001195098.1|NM_001195099.1|NM_015199.3	NP_001182027.1|NP_001182028.1|NP_056014.2	O15084	ANR28_HUMAN	ankyrin repeat domain 28							nucleoplasm	protein binding			breast(2)|endometrium(1)|large_intestine(2)|prostate(1)	6						ATGATAGGCCTAGAAATAAAT	0.313													2	4	---	---	---	---					
SLC51A	200931	broad.mit.edu	37	3	195955100	195955102	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr3:195955100_195955102delCTG	ENST00000296327.5	+	5	686_688	c.477_479delCTG	c.(475-480)ccctgc>ccc	p.C164del		NM_152672.5	NP_689885.4			solute carrier family 51, alpha subunit																		ACACAGGCCCctgctgctgctgc	0.665													7	147	---	---	---	---					
RSPH3	83861	broad.mit.edu	37	6	159420666	159420667	+	Frame_Shift_Ins	INS	-	-	T			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr6:159420666_159420667insT	ENST00000252655.1	-	1	531_532	c.342_343insA	c.(340-345)ttacatfs	p.H115fs	RSPH3_ENST00000297262.3_Frame_Shift_Ins_p.H115fs|RSPH3_ENST00000367069.2_5'UTR|RP1-111C20.4_ENST00000607391.1_RNA|RSPH3_ENST00000449822.1_5'UTR	NM_031924.4	NP_114130.3	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog (Chlamydomonas)	115										endometrium(3)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|skin(1)|stomach(7)	23		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		CCGGAGAGATGTAAGTAGTGCC	0.634													33	56	---	---	---	---					
PNLIPRP2	5408	broad.mit.edu	37	10	118396278	118396279	+	RNA	INS	-	-	T	rs11197776	by1000genomes	TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr10:118396278_118396279insT	ENST00000537242.1	+	0	962				PNLIPRP2_ENST00000298771.7_RNA|PNLIPRP2_ENST00000433618.4_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		ACAAATTATGGTTTTTTTTTTC	0.426													3	5	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49431090	49431105	+	Frame_Shift_Del	DEL	ACCATAGCCATGGATG	ACCATAGCCATGGATG	-	rs80149580	by1000genomes	TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr12:49431090_49431105delACCATAGCCATGGATG	ENST00000301067.7	-	34	10033_10048	c.10034_10049delCATCCATGGCTATGGT	c.(10033-10050)ccatccatggctatggtgfs	p.PSMAMV3345fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D									p.M3079T(1)									TTGATTGGACACCATAGCCATGGATGGAGCCAGGCG	0.616													9	17	---	---	---	---					
CCDC105	126402	broad.mit.edu	37	19	15121816	15121816	+	Frame_Shift_Del	DEL	A	A	-			TCGA-KC-A7FA-01A-21D-A33T-08	TCGA-KC-A7FA-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b63f37c1-b80c-44ba-9d98-1e621ee926d9	a792ba94-7862-4a44-9d3f-fbc56914f409	g.chr19:15121816delA	ENST00000292574.3	+	1	261	c.179delA	c.(178-180)cacfs	p.H61fs		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	61					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						AACGTGGCCCACCACCTCGGC	0.701													2	4	---	---	---	---					
