Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DNM1P47	0	broad.mit.edu	37	15	102296140	102296140	+	RNA	SNP	C	C	T			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr15:102296140C>T	ENST00000561463.1	+	0	4186																											GTCCAACCTGCACTCGCGTGG	0.602000													6	4					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5154617	5154617	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr12:5154617G>A	ENST00000252321.3	+	1	1533	c.1304G>A	c.(1303-1305)gGg>gAg	p.G435E		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	435						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						AGGGAGCTGGGGCTGCTCATC	0.592000													11	23					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71126310	71126310	+	Splice_Site	SNP	G	G	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr8:71126310G>A	ENST00000452400.2	-	4	268	c.87C>T	c.(85-87)agC>agT	p.S29S		NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	29					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			TCCTTTTGGGGCTTAAAAGAA	0.274000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								7	36					0	0	1	0	0
CLASP1	23332	broad.mit.edu	37	2	122144788	122144788	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr2:122144788G>A	ENST00000263710.4	-	32	3673	c.3284C>T	c.(3283-3285)aCg>aTg	p.T1095M	CLASP1_ENST00000541859.1_Missense_Mutation_p.T851M|CLASP1_ENST00000409078.3_Missense_Mutation_p.T1067M|CLASP1_ENST00000397587.3_Missense_Mutation_p.T1074M|CLASP1_ENST00000455322.2_Missense_Mutation_p.T1090M|CLASP1_ENST00000545861.1_Missense_Mutation_p.T841M|CLASP1_ENST00000541377.1_Missense_Mutation_p.T1073M	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	1095					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					CCGGCCAATCGTATTGCTTGG	0.522000													11	5					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2694691	2694691	+	Splice_Site	SNP	C	C	T			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr18:2694691C>T	ENST00000320876.6	+	8	1378	c.1040C>T	c.(1039-1041)gCg>gTg	p.A347V	SMCHD1_ENST00000261598.8_Splice_Site_p.A347V|RP11-703M24.5_ENST00000583546.1_RNA	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	347					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						CGACAGTTAGCGTAAGTAATT	0.358000													12	11					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237957207	237957207	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr1:237957207G>A	ENST00000366574.2	+	95	14140	c.13823G>A	c.(13822-13824)cGg>cAg	p.R4608Q	RYR2_ENST00000360064.6_Missense_Mutation_p.R4614Q|RYR2_ENST00000542537.1_Missense_Mutation_p.R4592Q	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4608					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAAGTGGCACGGAAATTGGAA	0.358000													15	17					0	0	1	0	0
DFNA5	1687	broad.mit.edu	37	7	24742404	24742404	+	Missense_Mutation	SNP	T	T	C			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr7:24742404T>C	ENST00000545231.1	-	11	1890	c.740A>G	c.(739-741)cAg>cGg	p.Q247R	DFNA5_ENST00000409775.3_Missense_Mutation_p.Q411R|DFNA5_ENST00000419307.1_Missense_Mutation_p.Q247R|DFNA5_ENST00000342947.3_Missense_Mutation_p.Q411R|DFNA5_ENST00000409970.1_Missense_Mutation_p.Q247R			O60443	DFNA5_HUMAN	deafness, autosomal dominant 5	411					sensory perception of sound					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(3)|stomach(1)	19						GGGAATGATCTGGAGTTTGCA	0.507000													11	73					0	0	1	0	0
PCDHAC2	0	broad.mit.edu	37	5	140347665	140347665	+	Silent	SNP	G	G	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr5:140347665G>A	ENST00000289269.5	+	1	1846	c.1314G>A	c.(1312-1314)acG>acA	p.T438T	PCDHA3_ENST00000522353.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHAC1_ENST00000253807.2_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		438	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAACATCACGGTGACAGCCA	0.552000													8	96					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146480607	146480607	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr6:146480607G>A	ENST00000392299.2	+	3	1294	c.824G>A	c.(823-825)cGc>cAc	p.R275H	GRM1_ENST00000492807.2_Missense_Mutation_p.R275H|GRM1_ENST00000355289.4_Missense_Mutation_p.R275H|GRM1_ENST00000282753.1_Missense_Mutation_p.R275H|GRM1_ENST00000507907.1_Missense_Mutation_p.R275H|GRM1_ENST00000361719.2_Missense_Mutation_p.R275H			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	275					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.R275H(1)		NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CGACTCTTGCGCAAACTCCGA	0.577000													22	25					0	0	1	0	0
MRPS24	64951	broad.mit.edu	37	7	43906439	43906439	+	Silent	SNP	G	G	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr7:43906439G>A	ENST00000317534.5	-	4	424	c.363C>T	c.(361-363)gcC>gcT	p.A121A	MRPS24_ENST00000467084.1_5'UTR|URGCP-MRPS24_ENST00000603700.1_3'UTR	NM_032014.2	NP_114403.1	Q96EL2	RT24_HUMAN	mitochondrial ribosomal protein S24	121					translation	mitochondrial large ribosomal subunit|mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	5						TCAGGACCACGGCACAGATCT	0.527000													3	52					0	0	1	0	0
SLC19A2	10560	broad.mit.edu	37	1	169439315	169439315	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr1:169439315G>A	ENST00000236137.5	-	3	1153	c.917C>T	c.(916-918)aCc>aTc	p.T306I	SLC19A2_ENST00000367804.4_Missense_Mutation_p.T105I	NM_006996.2	NP_008927.1	O60779	S19A2_HUMAN	solute carrier family 19 (thiamine transporter), member 2	306					thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|folic acid transporter activity|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	11	all_hematologic(923;0.208)					ATAGCCACAGGTAGAGAGGGC	0.507000													25	28					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63055788	63055788	+	Missense_Mutation	SNP	G	G	T			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr15:63055788G>T	ENST00000561311.1	+	39	5218	c.4988G>T	c.(4987-4989)tGt>tTt	p.C1663F	TLN2_ENST00000472902.1_Missense_Mutation_p.C56F|TLN2_ENST00000306829.6_Missense_Mutation_p.C1663F			Q9Y4G6	TLN2_HUMAN	talin 2	1663					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						CAGAGGGAGTGTGATTACTCC	0.622000													15	20					2.48551e-13	2.83071e-13	1	1	0
BRI3BP	140707	broad.mit.edu	37	12	125509710	125509710	+	Missense_Mutation	SNP	G	G	A	rs145269757		TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr12:125509710G>A	ENST00000341446.8	+	3	581	c.490G>A	c.(490-492)Gtc>Atc	p.V164I		NM_080626.5	NP_542193.3	Q8WY22	BRI3B_HUMAN	BRI3 binding protein	164						integral to membrane|mitochondrial outer membrane				large_intestine(1)|lung(8)|ovary(1)	10	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.35e-05)|Epithelial(86;0.000426)|all cancers(50;0.00576)		CGTGCGGGTCGTCCTGTTTTC	0.607000													10	83					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	53990499	53990499	+	Missense_Mutation	SNP	C	C	T			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr1:53990499C>T	ENST00000312233.2	-	5	1585	c.1019G>A	c.(1018-1020)cGc>cAc	p.R340H		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	340					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						GACGTGCTTGCGGAGGGAGCT	0.637000													15	78					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143081568	143081568	+	Missense_Mutation	SNP	C	C	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr6:143081568C>A	ENST00000367603.2	-	9	6599	c.5857G>T	c.(5857-5859)Gta>Tta	p.V1953L	HIVEP2_ENST00000367604.1_Missense_Mutation_p.V1953L|HIVEP2_ENST00000012134.2_Missense_Mutation_p.V1953L	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1953					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		CCGTGGGGTACGGCGCCAACA	0.478000													26	49					2.41591e-17	2.83007e-17	1	1	0
PDE1C	5137	broad.mit.edu	37	7	32109962	32109962	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr7:32109962G>A	ENST00000396184.3	-	2	248	c.44C>T	c.(43-45)tCt>tTt	p.S15F	PDE1C_ENST00000396191.1_Missense_Mutation_p.S15F|PDE1C_ENST00000396193.1_Intron|PDE1C_ENST00000396182.2_Missense_Mutation_p.S15F|PDE1C_ENST00000321453.7_Missense_Mutation_p.S15F	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	15					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			GTATTTCAGAGAGTTGCTCTC	0.527000													36	57					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390342	197390342	+	Missense_Mutation	SNP	G	G	T			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr1:197390342G>T	ENST00000367400.3	+	6	1519	c.1384G>T	c.(1384-1386)Gat>Tat	p.D462Y	CRB1_ENST00000367399.2_Missense_Mutation_p.D350Y|CRB1_ENST00000535699.1_Missense_Mutation_p.D393Y|CRB1_ENST00000476483.1_3'UTR|CRB1_ENST00000538660.1_Missense_Mutation_p.D462Y|CRB1_ENST00000544212.1_5'UTR|CRB1_ENST00000367397.1_5'UTR|CRB1_ENST00000543483.1_Missense_Mutation_p.D161Y	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	462	EGF-like 11.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TCACTTCCAAGATGGCCAGCA	0.483000													30	44					3.57733e-08	3.96407e-08	1	1	0
BCORL1	63035	broad.mit.edu	37	X	129149433	129149433	+	Silent	SNP	C	C	T			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chrX:129149433C>T	ENST00000540052.1	+	3	2729	c.2685C>T	c.(2683-2685)ttC>ttT	p.F895F	BCORL1_ENST00000359304.2_Silent_p.F895F|BCORL1_ENST00000218147.7_Silent_p.F895F|BCORL1_ENST00000303743.5_Silent_p.F895F	NM_021946.4	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	895					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus		p.S894fs*26(1)		breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GGGGCTCCTTCGTTCCAGAGC	0.562000													4	16					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39782157	39782157	+	Missense_Mutation	SNP	C	C	G			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr1:39782157C>G	ENST00000564288.1	+	28	4321	c.3544C>G	c.(3544-3546)Ctg>Gtg	p.L1182V	MACF1_ENST00000372915.3_Missense_Mutation_p.L1187V|MACF1_ENST00000539005.1_Missense_Mutation_p.L1187V|MACF1_ENST00000545844.1_Missense_Mutation_p.L1187V|MACF1_ENST00000361689.2_Missense_Mutation_p.L1187V|MACF1_ENST00000567887.1_Missense_Mutation_p.L1219V|MACF1_ENST00000317713.7_Missense_Mutation_p.L1187V|MACF1_ENST00000476350.1_3'UTR			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	1187					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGAAGTAGTACTGGCAGATCT	0.438000													30	113					0	0	1	0	0
LARS	51520	broad.mit.edu	37	5	145547808	145547808	+	Missense_Mutation	SNP	T	T	G			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr5:145547808T>G	ENST00000394434.2	-	5	481	c.315A>C	c.(313-315)aaA>aaC	p.K105N	LARS_ENST00000510191.1_Missense_Mutation_p.K51N|LARS_ENST00000511505.1_Intron|LARS_ENST00000545646.1_Intron|LARS_ENST00000274562.9_Missense_Mutation_p.K78N	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	105					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CTATTTCTCTTTTCAACTTAT	0.338000													23	63					0	0	1	0	0
L3MBTL2	83746	broad.mit.edu	37	22	41620063	41620063	+	Missense_Mutation	SNP	C	C	T			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr22:41620063C>T	ENST00000216237.5	+	9	1140	c.982C>T	c.(982-984)Cgg>Tgg	p.R328W		NM_031488.4	NP_113676.2	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2 (Drosophila)	328					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GCAGGGCATGCGGCTGGAAGT	0.597000													4	58					0	0	1	0	0
OR5AR1	219493	broad.mit.edu	37	11	56431734	56431734	+	Silent	SNP	C	C	T			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr11:56431734C>T	ENST00000302969.2	+	1	597	c.573C>T	c.(571-573)gaC>gaT	p.D191D		NM_001004730.1	NP_001004730.1	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR, member 1 (gene/pseudogene)	191					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(12)|prostate(1)|skin(3)|stomach(1)	26						CTTGCTCAGACACCTACATCA	0.458000													12	123					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97779509	97779509	+	Silent	SNP	C	C	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr2:97779509C>A	ENST00000420699.2	+	1	277	c.33C>A	c.(31-33)acC>acA	p.T11T	ANKRD36_ENST00000461153.2_Silent_p.T11T	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	11										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						GGTGGCCCACCCTCATGGAGC	0.552000													6	108					0.0215528	0.0220916	1	1	0
WDR47	22911	broad.mit.edu	37	1	109553736	109553736	+	Missense_Mutation	SNP	C	C	T			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr1:109553736C>T	ENST00000357672.3	-	4	1223	c.848G>A	c.(847-849)cGc>cAc	p.R283H	WDR47_ENST00000369962.3_Missense_Mutation_p.R311H|WDR47_ENST00000361054.3_Missense_Mutation_p.R283H|WDR47_ENST00000400794.3_Missense_Mutation_p.R318H|WDR47_ENST00000369965.4_Missense_Mutation_p.R311H			O94967	WDR47_HUMAN	WD repeat domain 47	311										breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		ATTCAGAGAGCGGGTCATATA	0.453000													5	300					0	0	1	0	0
TENC1	23371	broad.mit.edu	37	12	53452948	53452948	+	Missense_Mutation	SNP	C	C	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr12:53452948C>A	ENST00000314250.6	+	18	1813	c.1523C>A	c.(1522-1524)tCt>tAt	p.S508Y	TENC1_ENST00000314276.3_Missense_Mutation_p.S518Y|TENC1_ENST00000552570.1_Missense_Mutation_p.S508Y|TENC1_ENST00000379902.3_Missense_Mutation_p.S384Y|TENC1_ENST00000451358.1_Missense_Mutation_p.S508Y|TENC1_ENST00000549700.1_Missense_Mutation_p.S508Y|TENC1_ENST00000546602.1_Missense_Mutation_p.S508Y	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	508	Pro-rich.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						CCCATGCTCTCTGTCAGCAGC	0.701000													3	40					0.115264	0.115264	1	1	0
GPR179	440435	broad.mit.edu	37	17	36499576	36499576	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr17:36499576G>A	ENST00000342292.4	-	1	117	c.97C>T	c.(97-99)Cgc>Tgc	p.R33C		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	33						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GGCAGAGAGCGGATGGGCCGT	0.652000													12	27					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306846	54306846	+	Silent	SNP	G	G	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr15:54306846G>A	ENST00000545554.1	+	1	1746	c.1746G>A	c.(1744-1746)tcG>tcA	p.S582S	UNC13C_ENST00000260323.11_Silent_p.S582S|UNC13C_ENST00000537900.1_Silent_p.S582S			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	582					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGTCATCTTCGGACCGGGAGC	0.453000													17	29					0	0	1	0	0
SEMA7A	8482	broad.mit.edu	37	15	74703021	74703021	+	Missense_Mutation	SNP	C	C	T			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr15:74703021C>T	ENST00000261918.4	-	14	2493	c.1945G>A	c.(1945-1947)Gcc>Acc	p.A649T	SEMA7A_ENST00000542748.1_Missense_Mutation_p.A484T|SEMA7A_ENST00000543145.2_Missense_Mutation_p.A635T	NM_003612.3	NP_003603.1	O75326	SEM7A_HUMAN	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	649					axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	30						CAGAGGGAGGCGGCCAGGGCA	0.687000													34	29					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113942610	113942610	+	Missense_Mutation	SNP	G	G	T			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr2:113942610G>T	ENST00000441564.3	+	3	1302	c.1133G>T	c.(1132-1134)gGa>gTa	p.G378V	PSD4_ENST00000245796.6_Missense_Mutation_p.G378V			Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4						regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ggatgtgtcggatctgatctt	0.537000													82	93					1.59627e-33	1.92491e-33	1	1	0
SSTR4	6754	broad.mit.edu	37	20	23016627	23016627	+	Silent	SNP	C	C	T			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr20:23016627C>T	ENST00000255008.3	+	1	571	c.507C>T	c.(505-507)ggC>ggT	p.G169G	RP4-753D10.3_ENST00000440921.1_RNA	NM_001052.2	NP_001043.2	P31391	SSR4_HUMAN	somatostatin receptor 4	169					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TCAACCTGGGCGTGTGGCTGG	0.697000													29	38					0	0	1	0	0
F10	2159	broad.mit.edu	37	13	113798308	113798308	+	Missense_Mutation	SNP	G	G	A	rs144711550	byFrequency	TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr13:113798308G>A	ENST00000375559.3	+	6	684	c.646G>A	c.(646-648)Gac>Aac	p.D216N	F10_ENST00000409306.1_Missense_Mutation_p.D216N|F10_ENST00000375551.3_Missense_Mutation_p.D216N	NM_000504.3	NP_000495.1	P00742	FA10_HUMAN	coagulation factor X	216					blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(4)|lung(10)|pancreas(1)|stomach(1)	18	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAACCCCTTCGACCTGCTTGA	0.632000													9	36					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51868974	51868974	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr12:51868974G>A	ENST00000453097.2	+	16	2373	c.2156G>A	c.(2155-2157)cGt>cAt	p.R719H	SLC4A8_ENST00000514353.3_Missense_Mutation_p.R666H|SLC4A8_ENST00000358657.3_Missense_Mutation_p.R746H|SLC4A8_ENST00000394856.1_Missense_Mutation_p.R666H	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	719					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		AAGACGAGCCGTTATTTCCCA	0.428000													7	79					0	0	1	0	0
DDX21	9188	broad.mit.edu	37	10	70728789	70728789	+	Missense_Mutation	SNP	T	T	C			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr10:70728789T>C	ENST00000354185.4	+	7	1246	c.1148T>C	c.(1147-1149)tTt>tCt	p.F383S		NM_001256910.1|NM_004728.3	NP_001243839.1|NP_004719.2	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 21	383	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	20						CATTGGGTATTTAATGTTGCC	0.358000													3	93					0	0	1	0	0
MCAM	4162	broad.mit.edu	37	11	119182607	119182607	+	Missense_Mutation	SNP	C	C	T			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr11:119182607C>T	ENST00000392814.1	-	5	1772	c.1043G>A	c.(1042-1044)cGg>cAg	p.R348Q	MCAM_ENST00000264036.4_Missense_Mutation_p.R399Q			P43121	MUC18_HUMAN	melanoma cell adhesion molecule	399	Ig-like C2-type 2.				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|skin(1)	22		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		TCCTGCCTCCCGTTTCAGGTC	0.602000													4	107					0	0	1	0	0
UBXN4	23190	broad.mit.edu	37	2	136537785	136537785	+	Frame_Shift_Del	DEL	T	T	-			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr2:136537785delT	ENST00000272638.9	+	12	1529	c.1218delT	c.(1216-1218)tctfs	p.S408fs	UBXN4_ENST00000490163.1_3'UTR	NM_014607.3	NP_055422.1	Q92575	UBXN4_HUMAN	UBX domain protein 4	408					response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	24						TTGTACACTCTTCCAGCGGAG	0.428													33	79	---	---	---	---					
THBS4	7060	broad.mit.edu	37	5	79372774	79372776	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr5:79372774_79372776delTGA	ENST00000350881.2	+	16	2179_2181	c.1989_1991delTGA	c.(1987-1992)tgtgat>tgt	p.D668del	CTD-2201I18.1_ENST00000514042.1_RNA|CTD-2201I18.1_ENST00000503007.1_RNA|THBS4_ENST00000511733.1_In_Frame_Del_p.D577del	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	668					endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		GTGACGAGTGTGATGATGATGAT	0.562													8	266	---	---	---	---					
SNAP91	9892	broad.mit.edu	37	6	84350856	84350856	+	Frame_Shift_Del	DEL	T	T	-			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr6:84350856delT	ENST00000428679.2	-	8	1317	c.724delA	c.(724-726)actfs	p.T242fs	SNAP91_ENST00000520302.1_Frame_Shift_Del_p.T242fs|SNAP91_ENST00000521485.1_Frame_Shift_Del_p.T242fs|SNAP91_ENST00000437520.1_Frame_Shift_Del_p.T242fs|SNAP91_ENST00000369694.2_Frame_Shift_Del_p.T242fs|SNAP91_ENST00000520213.1_Frame_Shift_Del_p.T242fs|SNAP91_ENST00000439399.2_Frame_Shift_Del_p.T242fs|SNAP91_ENST00000521743.1_Frame_Shift_Del_p.T242fs|SNAP91_ENST00000195649.6_Frame_Shift_Del_p.T242fs			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	242					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		GTCATTCTAGTTAGAAATCGT	0.289													2	4	---	---	---	---					
SKIDA1	387640	broad.mit.edu	37	10	21805466	21805467	+	In_Frame_Ins	INS	-	-	CCTCCT	rs138084841	by1000genomes	TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr10:21805466_21805467insCCTCCT	ENST00000449193.2	-	4	3537_3538	c.1285_1286insAGGAGG	c.(1285-1287)ggg>gAGGAGGgg	p.428_429insEE	SKIDA1_ENST00000444772.3_In_Frame_Ins_p.349_350insEE	NM_207371.3	NP_997254.3			SKI/DACH domain containing 1									p.E428_G429insEE(2)									CCCGCTGCccccctcctcctcc	0.619													2	4	---	---	---	---					
NRGN	4900	broad.mit.edu	37	11	124615605	124615605	+	Frame_Shift_Del	DEL	C	C	-			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr11:124615605delC	ENST00000284292.6	+	2	461	c.222delC	c.(220-222)ggcfs	p.G74fs	RP11-677M14.2_ENST00000531241.1_RNA|NRGN_ENST00000412681.2_Frame_Shift_Del_p.G74fs	NM_001126181.1|NM_006176.2	NP_001119653.1|NP_006167.1	Q92686	NEUG_HUMAN	neurogranin (protein kinase C substrate, RC3)		Collagen-like.				nervous system development|signal transduction		calmodulin binding					all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		cgggcggcggccccAGCGGAG	0.761													2	4	---	---	---	---					
LRRIQ1	84125	broad.mit.edu	37	12	85466829	85466830	+	Frame_Shift_Ins	INS	-	-	A			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr12:85466829_85466830insA	ENST00000393217.2	+	11	2901_2902	c.2840_2841insA	c.(2839-2844)acaaaafs	p.TK947fs		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	947										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		ACCTCACTTACAAAAAATTCAG	0.371													39	56	---	---	---	---					
TPTE2P1	0	broad.mit.edu	37	13	25527490	25527491	+	RNA	INS	-	-	AAAAAG			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr13:25527490_25527491insAAAAAG	ENST00000429698.1	-	0	282																											AGGAAGGTTCTAAAAAAAATTT	0.252													4	4	---	---	---	---					
hsa-mir-6080	0	broad.mit.edu	37	17	62750914	62750914	+	RNA	DEL	T	T	-			TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chr17:62750914delT	ENST00000400873.3	-	0	1841					NR_026899.1																						CTGATTATGCttttttttttg	0.433													3	4	---	---	---	---					
NUDT11	0	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	TCCTCGAGGCAGCC	-	rs78182391		TCGA-M7-A71Z-01A-12D-A32B-08	TCGA-M7-A71Z-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4906782-9697-4813-942b-94c2b8463d5c	fa6e02fd-442a-4a16-8d8d-d85944432531	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	ENST00000375992.3	-	0	139_152					NM_018159.3	NP_060629.2	Q96G61	NUD11_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.?(5)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	9	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.692										HNSCC(48;0.14)			5	5	---	---	---	---					
