Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LSP1	4046	broad.mit.edu	37	11	1901362	1901362	+	Missense_Mutation	SNP	C	C	A	rs150172209		TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr11:1901362C>A	ENST00000381775.1	+	3	591	c.483C>A	c.(481-483)caC>caA	p.H161Q	LSP1_ENST00000406638.2_5'UTR|LSP1_ENST00000405957.2_5'UTR|LSP1_ENST00000311604.3_Missense_Mutation_p.H33Q	NM_001242932.1	NP_001229861.1	P33241	LSP1_HUMAN	lymphocyte-specific protein 1	33					cellular component movement|cellular defense response	actin cytoskeleton|Golgi apparatus|plasma membrane	actin binding|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|Lung(200;0.0729)|LUSC - Lung squamous cell carcinoma(625;0.0856)		AGGCCGTCCACGAGCAATGCC	0.647000													8	34					0.000157383	0.000165968	1	1	0
BTN2A3P	0	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													5	145					0	0	1	0	0
TBCD	6904	broad.mit.edu	37	17	80739569	80739569	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr17:80739569T>C	ENST00000355528.4	+	7	873	c.743T>C	c.(742-744)aTc>aCc	p.I248T	TBCD_ENST00000397466.2_5'UTR|TBCD_ENST00000539345.2_Missense_Mutation_p.I248T	NM_005993.4	NP_005984.3	Q9BTW9	TBCD_HUMAN	tubulin folding cofactor D	248					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity					Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			CAGGGGGTCATCACCATGGAT	0.587000											OREG0024827	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	66					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32526716	32526716	+	Missense_Mutation	SNP	C	C	T	rs77092908	byFrequency	TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr21:32526716C>T	ENST00000286827.3	-	18	3491	c.3020G>A	c.(3019-3021)cGc>cAc	p.R1007H	TIAM1_ENST00000541036.1_Missense_Mutation_p.R947H	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1007					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						ATGCAAACTGCGGCAAAATGC	0.577000													4	105					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16946532	16946532	+	RNA	SNP	G	G	C			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:16946532G>C	ENST00000412962.1	-	0	1000																											AGGGGGCCAGGACTGGACGCG	0.682000													4	17					0	0	1	0	0
PTRH1	138428	broad.mit.edu	37	9	130477855	130477855	+	Silent	SNP	A	A	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr9:130477855A>G	ENST00000419060.1	-	2	1520	c.64T>C	c.(64-66)Ttg>Ctg	p.L22L	C9orf117_ENST00000464092.1_3'UTR|C9orf117_ENST00000373293.5_3'UTR|PTRH1_ENST00000543175.1_Silent_p.L22L|PTRH1_ENST00000423807.1_Silent_p.L22L			Q86Y79	PTH_HUMAN	peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)	22					translation		aminoacyl-tRNA hydrolase activity|protein binding			NS(1)	1						CGAGGCTCCAAAACACATCGG	0.677000													14	24					0	0	1	0	0
GUSBP11	0	broad.mit.edu	37	22	23980782	23980782	+	RNA	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr22:23980782G>A	ENST00000455485.1	-	0	3707				KB-1572G7.3_ENST00000390329.3_RNA|AP000347.4_ENST00000430707.2_RNA																							GCAGCTCCAGGCCCCTGTGGG	0.567000													9	17					0	0	1	0	0
SGIP1	84251	broad.mit.edu	37	1	67154846	67154846	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:67154846C>T	ENST00000371037.4	+	16	1408	c.1331C>T	c.(1330-1332)gCt>gTt	p.A444V	SGIP1_ENST00000237247.6_Missense_Mutation_p.A475V|SGIP1_ENST00000371039.1_Missense_Mutation_p.A245V|SGIP1_ENST00000371035.3_Missense_Mutation_p.A234V|SGIP1_ENST00000371036.3_Missense_Mutation_p.A244V	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	444	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						TCATCCCCTGCTCGACCAGCC	0.537000													8	382					0	0	1	0	0
RBM39	9584	broad.mit.edu	37	20	34312500	34312500	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr20:34312500C>T	ENST00000361162.6	-	8	1063	c.679G>A	c.(679-681)Gca>Aca	p.A227T	RBM39_ENST00000528062.3_Missense_Mutation_p.A205T|RBM39_ENST00000253363.6_Missense_Mutation_p.A227T|RBM39_ENST00000407261.4_Missense_Mutation_p.A70T	NM_004902.3|NM_184234.2	NP_004893.1|NP_909122.1	Q14498	RBM39_HUMAN	RNA binding motif protein 39	227	RRM 1.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding	p.A227T(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					ACCTGTGATGCCTGTACTATG	0.433000													20	58					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50168708	50168708	+	Missense_Mutation	SNP	G	G	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr15:50168708G>T	ENST00000284509.6	-	25	2935	c.2794C>A	c.(2794-2796)Cag>Aag	p.Q932K	ATP8B4_ENST00000559829.1_Missense_Mutation_p.Q932K	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	932					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		ACGCTGTTCTGGTCACTCACA	0.423000													12	39					1.05317e-09	1.19772e-09	1	1	0
SH2D3C	10044	broad.mit.edu	37	9	130506867	130506867	+	Silent	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr9:130506867C>T	ENST00000314830.8	-	7	1889	c.1776G>A	c.(1774-1776)cgG>cgA	p.R592R	SH2D3C_ENST00000420366.1_Silent_p.R434R|SH2D3C_ENST00000373276.3_Silent_p.R524R|SH2D3C_ENST00000373277.4_Silent_p.R435R|SH2D3C_ENST00000429553.1_Silent_p.R238R|SH2D3C_ENST00000471939.1_5'UTR|SH2D3C_ENST00000373274.3_Silent_p.R432R	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	592	Ras-GEF.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TGGTGACATGCCGGGCCAGCG	0.632000													4	129					0	0	1	0	0
HOXD4	3233	broad.mit.edu	37	2	177016758	177016758	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr2:177016758G>A	ENST00000306324.3	+	1	809	c.397G>A	c.(397-399)Gtc>Atc	p.V133I	HOXD3_ENST00000468418.3_5'UTR	NM_014621.2	NP_055436.2	P09016	HXD4_HUMAN	homeobox D4	133						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00765)|Epithelial(96;0.105)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		GCCGGCCGTGGTCTACCCCTG	0.672000													6	45					0	0	1	0	0
C9orf96	169436	broad.mit.edu	37	9	136256483	136256483	+	Missense_Mutation	SNP	T	T	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr9:136256483T>G	ENST00000371957.3	+	7	601	c.494T>G	c.(493-495)cTc>cGc	p.L165R	C9orf96_ENST00000371955.1_5'UTR	NM_153710.3	NP_714921.4	Q8NE28	SGK71_HUMAN	chromosome 9 open reading frame 96	165	Protein kinase.						ATP binding|protein kinase activity			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|stomach(2)	25				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		AACATCATCCTCATCAGCAGT	0.552000													17	335					0	0	1	0	0
KRT27	342574	broad.mit.edu	37	17	38933946	38933946	+	Silent	SNP	A	A	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr17:38933946A>G	ENST00000301656.3	-	6	1051	c.1011T>C	c.(1009-1011)agT>agC	p.S337S	KRT27_ENST00000540723.1_5'UTR	NM_181537.3	NP_853515.2	Q7Z3Y8	K1C27_HUMAN	keratin 27	337	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity	p.S337R(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				CACAGTAGTTACTCTCGGTCT	0.527000													36	156					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211438054	211438054	+	Silent	SNP	A	A	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr2:211438054A>T	ENST00000233072.5	+	2	355	c.159A>T	c.(157-159)ggA>ggT	p.G53G	CPS1_ENST00000430249.2_Silent_p.G59G	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	53	Anthranilate phosphoribosyltransferase homolog.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TGGAAGATGGAACTAAGATGA	0.418000													35	67					0	0	1	0	0
WNT3A	89780	broad.mit.edu	37	1	228238397	228238397	+	Silent	SNP	C	C	T	rs151253698		TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:228238397C>T	ENST00000284523.1	+	3	432	c.354C>T	c.(352-354)gcC>gcT	p.A118A	WNT3A_ENST00000366753.2_Silent_p.A118A	NM_033131.3	NP_149122.1	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family, member 3A	118					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		Prostate(94;0.0405)				TTGCCTCAGCCGGTGTGGCCT	0.622000													18	15					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55496573	55496573	+	Missense_Mutation	SNP	T	T	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr19:55496573T>G	ENST00000543010.1	+	7	2332	c.2189T>G	c.(2188-2190)cTc>cGc	p.L730R	NLRP2_ENST00000263437.6_Missense_Mutation_p.L727R|NLRP2_ENST00000448584.2_Missense_Mutation_p.L730R|NLRP2_ENST00000391721.4_Missense_Mutation_p.L706R|NLRP2_ENST00000538819.1_Missense_Mutation_p.L706R|NLRP2_ENST00000537859.1_Missense_Mutation_p.L708R|NLRP2_ENST00000427260.2_Missense_Mutation_p.L707R|NLRP2_ENST00000339757.7_Missense_Mutation_p.L708R	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	730					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		ACCTGTCATCTCCAGAGAGTG	0.403000													6	83					0	0	1	0	0
OR4P4	81300	broad.mit.edu	37	11	55406191	55406191	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr11:55406191C>T	ENST00000314612.2	+	1	358	c.358C>T	c.(358-360)Cgc>Tgc	p.R120C		NM_001004124.1	NP_001004124.1	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P, member 4	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						GGCCTATGACCGCTATGTGGC	0.403000													21	60					0	0	1	0	0
PCDHGA2	0	broad.mit.edu	37	5	140719242	140719242	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr5:140719242C>T	ENST00000394576.2	+	1	704	c.704C>T	c.(703-705)gCg>gTg	p.A235V	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1												p.A235V(2)		breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCCTGGATGCGAACGACAAT	0.592000													4	81					0	0	1	0	0
OGG1	4968	broad.mit.edu	37	3	9798825	9798825	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr3:9798825G>A	ENST00000302003.7	+	7	1389	c.1046G>A	c.(1045-1047)cGg>cAg	p.R349Q	OGG1_ENST00000339511.5_3'UTR|OGG1_ENST00000302036.7_Intron|OGG1_ENST00000344629.7_Silent_p.P343P|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000449570.2_Intron|OGG1_ENST00000302008.8_Intron|OGG1_ENST00000349503.5_Intron	NM_002542.5|NM_016820.3	NP_002533.1|NP_058213.1	O15527	OGG1_HUMAN	8-oxoguanine DNA glycosylase	43					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					CCAAAGGGCCGGAAGGCTAGA	0.602000								Base excision repair (BER), DNA glycosylases					4	128					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43056985	43056985	+	Silent	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr20:43056985C>T	ENST00000316099.4	+	9	1229	c.1140C>T	c.(1138-1140)agC>agT	p.S380S	HNF4A_ENST00000457232.1_Silent_p.S358S|HNF4A_ENST00000415691.2_Silent_p.S380S|HNF4A_ENST00000316673.4_Silent_p.S358S	NM_000457.4|NM_001258355.1|NM_178849.2	NP_000448.3|NP_001245284.1|NP_849180.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha						blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GGTCCCCCAGCGATGCACCCC	0.592000													21	71					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133928258	133928258	+	Silent	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr9:133928258C>T	ENST00000361069.4	+	11	1978	c.1845C>T	c.(1843-1845)gaC>gaT	p.D615D	LAMC3_ENST00000480883.1_Intron	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	615	Laminin IV type A.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CCTCCGAGGACGTGGCCCCTC	0.697000											OREG0019556	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	63					0	0	1	0	0
OR2T1	26696	broad.mit.edu	37	1	248569715	248569715	+	Silent	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:248569715G>A	ENST00000366474.1	+	1	420	c.420G>A	c.(418-420)agG>agA	p.R140R		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGGATCAAAGGACCATTTCCT	0.478000													15	144					0	0	1	0	0
SIRT5	23408	broad.mit.edu	37	6	13592062	13592062	+	Silent	SNP	C	C	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr6:13592062C>A	ENST00000606117.1	+	5	707	c.411C>A	c.(409-411)gtC>gtA	p.V137V	SIRT5_ENST00000379262.4_Silent_p.V137V|SIRT5_ENST00000397350.2_Silent_p.V29V|SIRT5_ENST00000359782.3_Silent_p.V137V	NM_012241.4	NP_036373.1	Q9NXA8	SIRT5_HUMAN	sirtuin 5	137	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	11	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	GAGTCGTGGTCATCACCCAGA	0.652000													13	46					1.33834e-09	1.49276e-09	1	1	0
LIG4	3981	broad.mit.edu	37	13	108862482	108862482	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr13:108862482G>A	ENST00000356922.4	-	2	1407	c.1135C>T	c.(1135-1137)Cat>Tat	p.H379Y	LIG4_ENST00000442234.1_Missense_Mutation_p.H379Y|LIG4_ENST00000405925.1_Missense_Mutation_p.H379Y	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	379					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					AGAGTCTCATGCCCTAGCTTT	0.328000								Non-homologous end-joining					7	55					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21689987	21689987	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr20:21689987C>T	ENST00000398485.2	+	4	1241	c.1187C>T	c.(1186-1188)gCg>gTg	p.A396V	PAX1_ENST00000460221.1_3'UTR|PAX1_ENST00000444366.2_Missense_Mutation_p.A372V	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	396					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						TGGCCGCCTGCGCAAGGTCCT	0.736000													5	17					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113321171	113321171	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr12:113321171G>A	ENST00000389385.4	+	16	1897	c.1400G>A	c.(1399-1401)gGc>gAc	p.G467D	RPH3A_ENST00000549913.2_3'UTR|RPH3A_ENST00000415485.3_Missense_Mutation_p.G467D|RPH3A_ENST00000543106.2_Missense_Mutation_p.G467D|RPH3A_ENST00000551052.1_Missense_Mutation_p.G463D|RPH3A_ENST00000548866.1_Missense_Mutation_p.G418D|RPH3A_ENST00000447659.2_Missense_Mutation_p.G418D|RPH3A_ENST00000420983.2_Missense_Mutation_p.G467D	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	467	C2 1.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GTGTATCACGGCATCACCGAT	0.562000													3	26					0	0	1	0	0
FOXN2	3344	broad.mit.edu	37	2	48573435	48573435	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr2:48573435T>C	ENST00000340553.3	+	3	343	c.82T>C	c.(82-84)Tac>Cac	p.Y28H		NM_002158.3	NP_002149.2	P32314	FOXN2_HUMAN	forkhead box N2	28					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			AAGCCAGATTTACAAAATGGG	0.463000													38	86					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41836190	41836190	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr8:41836190G>A	ENST00000396930.3	-	7	1556	c.1013C>T	c.(1012-1014)cCa>cTa	p.P338L	KAT6A_ENST00000406337.1_Missense_Mutation_p.P338L|KAT6A_ENST00000265713.2_Missense_Mutation_p.P338L|KAT6A_ENST00000485568.1_Missense_Mutation_p.P338L	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	338	Interaction with RUNX1-1.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding	p.P338Q(1)									CCTGTTTTTTGGACGTCCTAT	0.403000													61	163					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158449735	158449735	+	Missense_Mutation	SNP	C	C	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:158449735C>A	ENST00000368152.1	+	1	68	c.68C>A	c.(67-69)gCa>gAa	p.A23E	RP11-144L1.4_ENST00000419738.1_RNA|RP11-144L1.4_ENST00000426251.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					CAGATCTTGGCAGAAAACCTC	0.423000													12	112					7.03913e-09	7.7032e-09	1	1	0
TRIM67	440730	broad.mit.edu	37	1	231299652	231299652	+	Missense_Mutation	SNP	A	A	C			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:231299652A>C	ENST00000444294.3	+	1	1795	c.937A>C	c.(937-939)Atg>Ctg	p.M313L	TRIM67_ENST00000366652.2_Missense_Mutation_p.M313L|TRIM67_ENST00000449018.3_Missense_Mutation_p.M251L|TRIM67_ENST00000366653.5_Missense_Mutation_p.M313L	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	313						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GAACTACAGCATGTACTGCGT	0.672000													3	6					0	0	1	0	0
RASSF4	83937	broad.mit.edu	37	10	45467247	45467247	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr10:45467247C>T	ENST00000340258.5	+	3	202	c.89C>T	c.(88-90)aCc>aTc	p.T30I	RASSF4_ENST00000472561.1_3'UTR|RASSF4_ENST00000334940.6_Intron|C10orf10_ENST00000496638.1_Intron|RASSF4_ENST00000374417.2_Missense_Mutation_p.T30I	NM_032023.3	NP_114412.2	Q9H2L5	RASF4_HUMAN	Ras association (RalGDS/AF-6) domain family member 4						cell cycle|signal transduction		protein binding			NS(1)|endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						CTGCTGAAAACCTACAACTGC	0.562000													8	51					0	0	1	0	0
UBIAD1	29914	broad.mit.edu	37	1	11345718	11345718	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:11345718G>A	ENST00000376810.5	+	2	873	c.547G>A	c.(547-549)Gtg>Atg	p.V183M	UBIAD1_ENST00000376804.2_Intron	NM_013319.2	NP_037451.1	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	183					menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity	p.V183M(1)		endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(3)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		ATTCAAGTACGTGGCTCTGGG	0.552000													4	54					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183521930	183521930	+	Silent	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr3:183521930C>T	ENST00000305135.5	+	27	3933	c.3738C>T	c.(3736-3738)gaC>gaT	p.D1246D		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1246					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TGAGGAATGACGGGGACTCCA	0.617000													4	156					0	0	1	0	0
FCRL2	79368	broad.mit.edu	37	1	157737056	157737056	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:157737056G>A	ENST00000361516.3	-	6	1175	c.1127C>T	c.(1126-1128)gCc>gTc	p.A376V	FCRL2_ENST00000469986.1_Missense_Mutation_p.A123V|FCRL2_ENST00000368181.4_Intron|FCRL2_ENST00000392274.3_Missense_Mutation_p.A376V	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	376	Ig-like C2-type 4.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			ACTGCACTGGGCCCCCAGGCC	0.572000													21	60					0	0	1	0	0
SENP6	26054	broad.mit.edu	37	6	76373050	76373050	+	Silent	SNP	A	A	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr6:76373050A>G	ENST00000370014.3	+	9	1429	c.810A>G	c.(808-810)ttA>ttG	p.L270L	SENP6_ENST00000447266.2_Silent_p.L270L|SENP6_ENST00000327284.8_Silent_p.L263L|SENP6_ENST00000370010.2_Silent_p.L263L	NM_001100409.1	NP_001093879.1	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6	270					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(105;0.189)				ACACAGGATTAACAACCAAGA	0.343000													15	66					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128812	45128812	+	RNA	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr17:45128812C>T	ENST00000575173.1	-	0	418																											AGTCCTGTTTCTGTGTGGATT	0.373000													4	25					0	0	1	0	0
ARAP1	116985	broad.mit.edu	37	11	72418283	72418283	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr11:72418283C>T	ENST00000359373.5	-	12	2511	c.1660G>A	c.(1660-1662)Ggg>Agg	p.G554R	ARAP1_ENST00000429686.1_Missense_Mutation_p.G309R|ARAP1_ENST00000426523.1_Missense_Mutation_p.G309R|ARAP1_ENST00000334211.8_Missense_Mutation_p.G309R|ARAP1_ENST00000455638.2_Missense_Mutation_p.G554R|ARAP1_ENST00000393609.3_Missense_Mutation_p.G554R|ARAP1_ENST00000393605.3_Missense_Mutation_p.G314R			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	554	Arf-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						TGAGGAGCCCCGCAGTCAGCA	0.642000													4	6					0	0	1	0	0
TNIP1	10318	broad.mit.edu	37	5	150415234	150415234	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr5:150415234C>T	ENST00000389378.2	-	14	2018	c.1430G>A	c.(1429-1431)cGc>cAc	p.R477H	TNIP1_ENST00000523338.1_Missense_Mutation_p.R477H|TNIP1_ENST00000524280.1_Missense_Mutation_p.R477H|TNIP1_ENST00000315050.7_Missense_Mutation_p.R477H|TNIP1_ENST00000521591.1_Missense_Mutation_p.R477H|TNIP1_ENST00000518977.1_Missense_Mutation_p.R477H|TNIP1_ENST00000523200.1_Missense_Mutation_p.R477H|TNIP1_ENST00000520931.1_Missense_Mutation_p.R424H|TNIP1_ENST00000522226.1_Missense_Mutation_p.R477H|TNIP1_ENST00000521423.1_Intron	NM_001252385.1|NM_001252393.1|NM_001258454.1|NM_006058.4	NP_001239314.1|NP_001239322.1|NP_001245383.1|NP_006049.3	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	477					defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(5)|ovary(2)|prostate(2)|skin(3)	23		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACGATCACTGCGCTCCCTCTG	0.577000													4	84					0	0	1	0	0
KPNA6	23633	broad.mit.edu	37	1	32622470	32622470	+	Missense_Mutation	SNP	A	A	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:32622470A>T	ENST00000373625.3	+	3	248	c.155A>T	c.(154-156)aAt>aTt	p.N52I	KPNA6_ENST00000537234.1_Missense_Mutation_p.N49I|KPNA6_ENST00000469790.1_3'UTR|KPNA6_ENST00000545542.1_Missense_Mutation_p.N57I	NM_012316.4	NP_036448.1	O60684	IMA7_HUMAN	karyopherin alpha 6 (importin alpha 7)	52	IBB.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			large_intestine(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				AAACGGAGAAATGTGGAGCTG	0.413000													12	68					0	0	1	0	0
DEFB110	245913	broad.mit.edu	37	6	49986788	49986788	+	Silent	SNP	T	T	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr6:49986788T>G	ENST00000371148.2	-	2	151	c.106A>C	c.(106-108)Aga>Cga	p.R36R	DEFB110_ENST00000393660.2_Intron	NM_001037497.1	NP_001032586.1	Q30KQ9	DB110_HUMAN	defensin, beta 110 locus	36					defense response to bacterium	extracellular region				endometrium(1)|lung(1)|ovary(1)	3	Lung NSC(77;0.042)					TTACCTATTCTGCACTCTCTC	0.393000													18	47					0	0	1	0	0
DSN1	79980	broad.mit.edu	37	20	35383221	35383221	+	Silent	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr20:35383221C>T	ENST00000426836.1	-	10	1278	c.906G>A	c.(904-906)ctG>ctA	p.L302L	DSN1_ENST00000373740.3_Silent_p.L230L|DSN1_ENST00000473615.1_5'UTR|DSN1_ENST00000373750.4_Silent_p.L302L|DSN1_ENST00000373734.4_Silent_p.L195L|DSN1_ENST00000448110.2_Silent_p.L286L|DSN1_ENST00000373745.3_Silent_p.L302L	NM_001145316.1	NP_001138788.1	Q9H410	DSN1_HUMAN	DSN1, MIS12 kinetochore complex component	302					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				TAAAGGCCTGCAGCTGTTTCA	0.473000													12	49					0	0	1	0	0
EOMES	8320	broad.mit.edu	37	3	27761814	27761814	+	Missense_Mutation	SNP	C	C	A			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr3:27761814C>A	ENST00000295743.4	-	2	1087	c.884G>T	c.(883-885)cGc>cTc	p.R295L	EOMES_ENST00000537516.1_5'UTR|EOMES_ENST00000461503.1_5'UTR|EOMES_ENST00000449599.1_Missense_Mutation_p.R295L			O95936	EOMES_HUMAN	eomesodermin	295					CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)	21						AGGAAACATGCGCCTGTGCAA	0.532000													12	124					0.000151284	0.000162491	1	1	0
DKFZP761J1410	0	broad.mit.edu	37	19	11470257	11470257	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr19:11470257C>T	ENST00000251473.5	+	4	492	c.116C>T	c.(115-117)aCg>aTg	p.T39M	DKFZP761J1410_ENST00000586431.1_3'UTR|DKFZP761J1410_ENST00000591608.1_Intron	NM_001170635.1|NM_022737.2	NP_001164106.1|NP_073574.2																					CTGGAGTTCACGGACACCTTC	0.622000													13	59					0	0	1	0	0
YY1AP1	55249	broad.mit.edu	37	1	155646464	155646464	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr1:155646464T>C	ENST00000368340.5	-	4	721	c.613A>G	c.(613-615)Atg>Gtg	p.M205V	YY1AP1_ENST00000359205.5_Missense_Mutation_p.M56V|YY1AP1_ENST00000361831.5_Missense_Mutation_p.M56V|YY1AP1_ENST00000405763.3_Missense_Mutation_p.M205V|YY1AP1_ENST00000476093.1_5'UTR|YY1AP1_ENST00000311573.5_Missense_Mutation_p.M56V|YY1AP1_ENST00000295566.4_Missense_Mutation_p.M133V|YY1AP1_ENST00000347088.5_Missense_Mutation_p.M67V|YY1AP1_ENST00000404643.1_Missense_Mutation_p.M67V|YY1AP1_ENST00000438245.2_Missense_Mutation_p.M67V|MSTO1_ENST00000538143.1_Intron|YY1AP1_ENST00000368339.5_Missense_Mutation_p.M205V|YY1AP1_ENST00000368330.2_Missense_Mutation_p.M67V|YY1AP1_ENST00000355499.4_Missense_Mutation_p.M67V|YY1AP1_ENST00000407221.1_Missense_Mutation_p.M56V|MSTO1_ENST00000452804.2_Intron	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					GGTTTCTTCATCTTCAGCTGT	0.443000													16	74					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97808401	97808401	+	Missense_Mutation	SNP	T	T	G			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr2:97808401T>G	ENST00000420699.2	+	7	1068	c.824T>G	c.(823-825)tTg>tGg	p.L275W	ANKRD36_ENST00000461153.2_Missense_Mutation_p.L275W	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	275										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						CAACCAGCCTTGAAGGTAATT	0.303000													3	29					0	0	1	0	0
OR8K1	390157	broad.mit.edu	37	11	56114074	56114074	+	Missense_Mutation	SNP	G	G	T			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr11:56114074G>T	ENST00000279783.2	+	1	654	c.560G>T	c.(559-561)tGt>tTt	p.C187F		NM_001002907.1	NP_001002907.1	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K, member 1	187					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					TACTGTGACTGTATCCCTCTG	0.353000										HNSCC(65;0.19)			4	90					1	1	1	1	0
OR4C11	219429	broad.mit.edu	37	11	55370956	55370956	+	Frame_Shift_Del	DEL	C	C	-	rs140139106		TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr11:55370956delC	ENST00000302231.4	-	1	918	c.894delG	c.(892-894)aagfs	p.K298fs		NM_001004700.2	NP_001004700.2	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C, member 11	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						CATGCCATAACTTTCTCATGG	0.363													11	45	---	---	---	---					
CELF6	60677	broad.mit.edu	37	15	72582049	72582049	+	Frame_Shift_Del	DEL	C	C	-			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chr15:72582049delC	ENST00000287202.5	-	6	920	c.666delG	c.(664-666)cggfs	p.R222fs	RP11-106M3.2_ENST00000379915.4_RNA|RP11-106M3.3_ENST00000570175.1_RNA|CELF6_ENST00000567083.1_Frame_Shift_Del_p.R222fs|CELF6_ENST00000569547.1_Frame_Shift_Del_p.R222fs|CELF6_ENST00000569311.1_5'UTR|CELF6_ENST00000395258.2_Frame_Shift_Del_p.R109fs|CELF6_ENST00000539635.1_Frame_Shift_Del_p.R83fs|CELF6_ENST00000543764.2_Frame_Shift_Del_p.R107fs	NM_052840.4	NP_443072.3	Q96J87	CELF6_HUMAN	CUGBP, Elav-like family member 6	222					mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(2)	13						TCTGCTGCATCCGCCGCAGCG	0.751													2	4	---	---	---	---					
RP13-228J13.1	0	broad.mit.edu	37	X	154578866	154578866	+	RNA	DEL	T	T	-			TCGA-QU-A6IO-01A-11D-A31L-08	TCGA-QU-A6IO-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1610fca4-8d42-4e49-8bac-0e2f2d6bd7c4	3667be24-0cb9-4641-85f0-8d65e011d511	g.chrX:154578866delT	ENST00000412436.1	-	0	98				RP13-228J13.5_ENST00000453508.1_RNA|RP13-228J13.1_ENST00000444722.1_RNA																							TTTCTCTCTGTTTTTTTTTTT	0.418													5	6	---	---	---	---					
