Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DNMT3B	1789	broad.mit.edu	37	20	31379479	31379479	+	Missense_Mutation	SNP	G	G	A	rs145632647	byFrequency	TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr20:31379479G>A	ENST00000328111.2	+	8	1207	c.886G>A	c.(886-888)Gtc>Atc	p.V296I	DNMT3B_ENST00000443239.3_Missense_Mutation_p.V254I|DNMT3B_ENST00000348286.2_Missense_Mutation_p.V296I|DNMT3B_ENST00000375623.4_Missense_Mutation_p.V254I|DNMT3B_ENST00000456297.2_Missense_Mutation_p.V220I|DNMT3B_ENST00000344505.4_Missense_Mutation_p.V296I|DNMT3B_ENST00000201963.3_Missense_Mutation_p.V308I|DNMT3B_ENST00000353855.2_Missense_Mutation_p.V296I	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	296	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CAATAAGCTCGTCTCCTATCG	0.498000													6	38					0	0	1	0	0
POM121L9P	0	broad.mit.edu	37	22	24659512	24659512	+	RNA	SNP	A	A	G			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr22:24659512A>G	ENST00000414583.2	+	0	3037					NR_003714.1																						TGCCTGGGCCATGGAGCACTC	0.473000													3	9					0	0	1	0	0
PYCR1	5831	broad.mit.edu	37	17	79892863	79892863	+	Missense_Mutation	SNP	G	G	A	rs139869668		TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr17:79892863G>A	ENST00000337943.5	-	4	921	c.479C>T	c.(478-480)aCg>aTg	p.T160M	PYCR1_ENST00000402252.2_Missense_Mutation_p.T187M|PYCR1_ENST00000577756.1_Missense_Mutation_p.T160M|PYCR1_ENST00000329875.8_Missense_Mutation_p.T160M|PYCR1_ENST00000403172.4_Missense_Mutation_p.T160M	NM_153824.1	NP_722546.1	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1	160					cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity			endometrium(2)|kidney(1)|lung(1)|prostate(1)	5	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	TTCCACCTCCGTGCAGAAGCC	0.692000													10	26					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155449429	155449429	+	Nonsense_Mutation	SNP	G	G	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr1:155449429G>A	ENST00000368346.3	-	3	3871	c.3232C>T	c.(3232-3234)Caa>Taa	p.Q1078*	ASH1L_ENST00000392403.3_Nonsense_Mutation_p.Q1078*			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1078					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GCTGCCTGTTGAGCTGTTTGC	0.433000													8	63					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12736537	12736537	+	Silent	SNP	C	C	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chrX:12736537C>A	ENST00000380682.1	+	16	4098	c.3592C>A	c.(3592-3594)Cgg>Agg	p.R1198R		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1198					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CTTGGCCAAGCGGATGTCATC	0.582000													6	97					0.00307968	0.00307968	1	1	0
UAP1L1	91373	broad.mit.edu	37	9	139975261	139975261	+	Silent	SNP	G	G	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr9:139975261G>A	ENST00000409858.3	+	7	1331	c.1299G>A	c.(1297-1299)cgG>cgA	p.R433R	UAP1L1_ENST00000360271.3_Silent_p.R310R	NM_207309.2	NP_997192.2	Q3KQV9	UAP1L_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1	433							nucleotidyltransferase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		AGCACTACCGGTGGGCTCTGC	0.687000													10	33					0	0	1	0	0
FBXO38	81545	broad.mit.edu	37	5	147781593	147781593	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr5:147781593T>C	ENST00000340253.5	+	4	479	c.311T>C	c.(310-312)gTt>gCt	p.V104A	FBXO38_ENST00000296701.6_Missense_Mutation_p.V104A|FBXO38_ENST00000394370.3_Missense_Mutation_p.V104A|FBXO38_ENST00000513826.1_Missense_Mutation_p.V104A|FBXO38_ENST00000509699.2_3'UTR			Q6PIJ6	FBX38_HUMAN	F-box protein 38	104	Interaction with KLF7 (By similarity).					cytoplasm|nucleus			ATG4C/FBXO38(2)	NS(1)|breast(2)|endometrium(7)|kidney(5)|large_intestine(9)|lung(15)|ovary(5)|prostate(2)|skin(2)|stomach(2)|urinary_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCCAGATGTTGAACAGCTA	0.438000													20	79					0	0	1	0	0
KIAA0391	9692	broad.mit.edu	37	14	35592719	35592719	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr14:35592719G>A	ENST00000557565.1	+	2	649	c.268G>A	c.(268-270)Gct>Act	p.A90T	KIAA0391_ENST00000321130.10_Missense_Mutation_p.A90T|KIAA0391_ENST00000605870.1_Intron|KIAA0391_ENST00000603544.1_Missense_Mutation_p.A90T|KIAA0391_ENST00000604948.1_5'UTR|KIAA0391_ENST00000534898.4_Missense_Mutation_p.A90T|KIAA0391_ENST00000250377.7_5'UTR|KIAA0391_ENST00000603588.1_Intron	NM_001282234.1	NP_001269163.1	O15091	MRRP3_HUMAN	KIAA0391	90					tRNA processing	mitochondrion				central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	14	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		AGCTGGAGCAGCTAAGGAGAG	0.418000													3	41					0	0	1	0	0
BPIFB4	149954	broad.mit.edu	37	20	31673924	31673924	+	Nonsense_Mutation	SNP	C	C	T			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr20:31673924C>T	ENST00000375483.3	+	5	880	c.880C>T	c.(880-882)Cga>Tga	p.R294*		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	294						cytoplasm|extracellular region	lipid binding										GGTCATTGAGCGATGTGACAC	0.572000													23	57					0	0	1	0	0
ADCY4	196883	broad.mit.edu	37	14	24791404	24791404	+	Silent	SNP	G	G	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr14:24791404G>A	ENST00000310677.4	-	21	2567	c.2454C>T	c.(2452-2454)ttC>ttT	p.F818F	ADCY4_ENST00000554068.2_Silent_p.F818F|ADCY4_ENST00000418030.2_Silent_p.F818F	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	818					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		TCTTCCACAGGAAGTCCAGGC	0.617000													6	107					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161529848	161529848	+	Missense_Mutation	SNP	A	A	G			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr6:161529848A>G	ENST00000392142.4	+	22	4341	c.4193A>G	c.(4192-4194)aAa>aGa	p.K1398R	MAP3K4_ENST00000366919.2_Missense_Mutation_p.K1348R|MAP3K4_ENST00000366920.2_Missense_Mutation_p.K1394R|MAP3K4_ENST00000348824.7_Missense_Mutation_p.K1344R	NM_005922.2	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1398	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		GAAGGCATCAAACACCCCAAT	0.423000													7	165					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128484281	128484281	+	Silent	SNP	G	G	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr7:128484281G>A	ENST00000325888.8	+	20	3414	c.3153G>A	c.(3151-3153)ccG>ccA	p.P1051P	FLNC_ENST00000346177.6_Silent_p.P1051P	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1051					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CTGGCAGCCCGTTTGCTGTGG	0.627000													3	20					0	0	1	0	0
STK39	27347	broad.mit.edu	37	2	169038559	169038559	+	Missense_Mutation	SNP	G	G	T			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr2:169038559G>T	ENST00000355999.4	-	2	955	c.250C>A	c.(250-252)Ccc>Acc	p.P84T		NM_013233.2	NP_037365.2	Q9UEW8	STK39_HUMAN	serine threonine kinase 39	84	Protein kinase.				response to stress	cytoplasm|nucleus	ATP binding|protein binding|receptor signaling protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|skin(2)	13						TCTTGCCTGGGTTTGCATAGG	0.448000													10	55					7.48243e-07	7.62914e-07	1	1	0
HTT	3064	broad.mit.edu	37	4	3205828	3205828	+	Missense_Mutation	SNP	A	A	G			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr4:3205828A>G	ENST00000355072.5	+	42	5816	c.5671A>G	c.(5671-5673)Aga>Gga	p.R1891G		NM_002111.6	NP_002102	P42858	HD_HUMAN	huntingtin	1891					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		AATGTGCAATAGAGAAATAGT	0.468000													30	47					0	0	1	0	0
HBD	3045	broad.mit.edu	37	11	5255334	5255334	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr11:5255334C>T	ENST00000380299.3	-	2	416	c.202G>A	c.(202-204)Gtg>Atg	p.V68M	HBD_ENST00000292901.3_Missense_Mutation_p.V68M	NM_000519.3	NP_000510.1	P02042	HBD_HUMAN	hemoglobin, delta	68					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	16		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCACCTAGCACCTTCTTGCCA	0.542000													4	102					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35406946	35406946	+	Silent	SNP	C	C	T			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr8:35406946C>T	ENST00000287272.2	+	2	260	c.240C>T	c.(238-240)gcC>gcT	p.A80A	UNC5D_ENST00000404895.2_Silent_p.A80A|UNC5D_ENST00000420357.1_Silent_p.A80A|UNC5D_ENST00000416672.1_Silent_p.A80A|UNC5D_ENST00000453357.2_Silent_p.A75A			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	80	Ig-like.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CGAGGCCAGCCATGCAGATAT	0.517000													11	43					0	0	1	0	0
FEM1A	55527	broad.mit.edu	37	19	4793551	4793551	+	Missense_Mutation	SNP	A	A	G			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr19:4793551A>G	ENST00000269856.3	+	1	1824	c.1685A>G	c.(1684-1686)cAc>cGc	p.H562R	AC005523.2_ENST00000601192.1_RNA	NM_018708.2	NP_061178.1	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a (C. elegans)	562					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	17		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		CCCTCCCTGCACGTGGTCAAA	0.632000													8	36					0	0	1	0	0
ACVRL1	94	broad.mit.edu	37	12	52306277	52306277	+	Missense_Mutation	SNP	A	A	G			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr12:52306277A>G	ENST00000550683.1	+	1	162	c.61A>G	c.(61-63)Agg>Ggg	p.R21G	ACVRL1_ENST00000419526.2_Missense_Mutation_p.R21G|ACVRL1_ENST00000388922.4_Missense_Mutation_p.R7G	NM_001077401.1	NP_001070869.1	P37023	ACVL1_HUMAN	activin A receptor type II-like 1	7					blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	GGGCTCCCCCAGGAAAGGCCT	0.592000													5	26					0	0	1	0	0
SLITRK5	26050	broad.mit.edu	37	13	88330033	88330033	+	Missense_Mutation	SNP	A	A	C	rs11840163	byFrequency	TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr13:88330033A>C	ENST00000325089.6	+	2	2609	c.2390A>C	c.(2389-2391)cAg>cCg	p.Q797P	SLITRK5_ENST00000400028.3_Missense_Mutation_p.Q556P	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	797						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					cagcagcagcagccgccgccg	0.667000													3	22					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92763220	92763220	+	Nonsense_Mutation	SNP	G	G	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr7:92763220G>A	ENST00000318238.4	-	5	3281	c.2065C>T	c.(2065-2067)Cga>Tga	p.R689*	SAMD9L_ENST00000437805.1_Nonsense_Mutation_p.R689*|SAMD9L_ENST00000411955.1_Nonsense_Mutation_p.R689*	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	689										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TTGCCACCTCGATAAAAGTGT	0.333000													12	74					0	0	1	0	0
PDE7A	5150	broad.mit.edu	37	8	66701169	66701169	+	Missense_Mutation	SNP	A	A	C			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr8:66701169A>C	ENST00000379419.4	-	1	150	c.8T>G	c.(7-9)aTt>aGt	p.I3S	PDE7A_ENST00000396642.3_Intron|PDE7A_ENST00000401827.3_Intron	NM_002603.3	NP_002594.1	Q13946	PDE7A_HUMAN	phosphodiesterase 7A	0						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			large_intestine(5)|lung(3)|stomach(1)|urinary_tract(1)	10			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	GATCAATGTAATTCCCATTGG	0.418000													38	87					0	0	1	0	0
NEDD9	4739	broad.mit.edu	37	6	11213711	11213711	+	Nonsense_Mutation	SNP	G	G	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr6:11213711G>A	ENST00000379446.5	-	2	428	c.262C>T	c.(262-264)Caa>Taa	p.Q88*	RP3-510L9.1_ENST00000500636.2_RNA|NEDD9_ENST00000504387.1_Nonsense_Mutation_p.Q88*|NEDD9_ENST00000379433.5_Nonsense_Mutation_p.Q88*	NM_001271033.1|NM_006403.3	NP_001257962.1|NP_006394.1	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally down-regulated 9	88					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding			endometrium(3)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			AGCTTCTGTTGGCCAAAGGTC	0.557000													3	71					0	0	1	0	0
C1orf131	128061	broad.mit.edu	37	1	231362810	231362810	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr1:231362810C>T	ENST00000318906.2	-	4	543	c.515G>A	c.(514-516)cGt>cAt	p.R172H	C1orf131_ENST00000366649.2_Missense_Mutation_p.R172H|C1orf131_ENST00000366651.3_Missense_Mutation_p.R171H			Q8NDD1	CA131_HUMAN	chromosome 1 open reading frame 131	172										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	8	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				CACTTCTAAACGAGCCTGCGG	0.483000													4	33					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34157424	34157424	+	Silent	SNP	A	A	C			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr15:34157424A>C	ENST00000389232.4	+	104	14680	c.14610A>C	c.(14608-14610)ggA>ggC	p.G4870G	RYR3_ENST00000415757.3_Silent_p.G4865G	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	4870					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ATCAGCTTGGATAAATCTGAA	0.393000													5	28					0	0	1	0	0
SNRPN	6638	broad.mit.edu	37	15	25223426	25223426	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr15:25223426C>T	ENST00000444203.2	+	7	1697	c.658C>T	c.(658-660)Ccg>Tcg	p.P220S	SNRPN_ENST00000577565.1_Missense_Mutation_p.P216S|SNRPN_ENST00000400098.1_Missense_Mutation_p.P216S|SNURF_ENST00000551312.2_Intron|SNRPN_ENST00000400100.1_Missense_Mutation_p.P216S|SNURF_ENST00000338094.6_3'UTR|SNRPN_ENST00000400097.1_Missense_Mutation_p.P216S|SNRPN_ENST00000346403.6_Missense_Mutation_p.P216S|SNRPN_ENST00000554227.2_Missense_Mutation_p.P220S|SNRPN_ENST00000390687.4_Missense_Mutation_p.P216S			P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	216	Repeat-rich region.				RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(2)	24		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		AATAGGCATGCCGCCTCCGGG	0.562000									Prader-Willi syndrome				4	133					0	0	1	0	0
TMEM40	55287	broad.mit.edu	37	3	12785418	12785418	+	Silent	SNP	G	G	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr3:12785418G>A	ENST00000314124.7	-	4	638	c.282C>T	c.(280-282)ccC>ccT	p.P94P	TMEM40_ENST00000264728.8_Silent_p.P94P|TMEM40_ENST00000431022.2_Silent_p.P110P|TMEM40_ENST00000435218.2_Intron|TMEM40_ENST00000435575.1_Intron	NM_001284406.1|NM_018306.2	NP_001271335.1|NP_060776.2	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	94						integral to membrane				breast(1)|large_intestine(3)|lung(5)|urinary_tract(1)	10						CGTTCCCGTGGGGGTATCCAG	0.542000													3	56					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63481745	63481745	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr18:63481745C>T	ENST00000536984.2	+	4	1224	c.530C>T	c.(529-531)gCg>gTg	p.A177V	CDH7_ENST00000323011.3_Missense_Mutation_p.A177V|CDH7_ENST00000397968.2_Missense_Mutation_p.A177V			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	177	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				CAAGTGACAGCGACGGATGCT	0.438000													4	108					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73326638	73326638	+	Missense_Mutation	SNP	T	T	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr10:73326638T>A	ENST00000224721.6	+	6	589	c.584T>A	c.(583-585)aTc>aAc	p.I195N	CDH23_ENST00000398809.4_Missense_Mutation_p.I190N|CDH23_ENST00000461841.3_Missense_Mutation_p.I235N|CDH23_ENST00000398842.3_Missense_Mutation_p.I190N|CDH23_ENST00000299366.7_Missense_Mutation_p.I235N	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	190	Cadherin 2.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GTCACAGTGATCCGGGAGCTG	0.652000													5	36					0	0	1	0	0
MAOA	4128	broad.mit.edu	37	X	43590980	43590980	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chrX:43590980G>A	ENST00000338702.3	+	8	958	c.835G>A	c.(835-837)Gcc>Acc	p.A279T	MAOA_ENST00000542639.1_Missense_Mutation_p.A146T	NM_000240.3	NP_000231.1	P21397	AOFA_HUMAN	monoamine oxidase A	279					behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	18					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	GACCTTGACTGCCAAGATTCA	0.443000													17	30					0	0	1	0	0
CITED2	10370	broad.mit.edu	37	6	139694303	139694303	+	Missense_Mutation	SNP	A	A	T			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr6:139694303A>T	ENST00000367651.2	-	2	994	c.779T>A	c.(778-780)gTg>gAg	p.V260E	CITED2_ENST00000537332.1_Missense_Mutation_p.V260E|CITED2_ENST00000536159.1_Missense_Mutation_p.V260E	NM_006079.4	NP_006070.2	Q99967	CITE2_HUMAN	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	260					adrenal cortex formation|anti-apoptosis|cell proliferation|determination of left/right symmetry|heart development|liver development|negative regulation of cell migration|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell cycle|positive regulation of cell-cell adhesion|positive regulation of male gonad development|positive regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of organ formation|response to estrogen stimulus|response to fluid shear stress|response to hypoxia|sex determination	cytoplasm|nuclear chromatin|nucleus	chromatin binding|LBD domain binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)|lung(4)	5	Breast(32;0.226)			GBM - Glioblastoma multiforme(68;0.000171)|OV - Ovarian serous cystadenocarcinoma(155;0.00134)		CTGTTTGCACACGAAGTCCGT	0.488000													4	96					0	0	1	0	0
NOX3	50508	broad.mit.edu	37	6	155750120	155750120	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr6:155750120G>A	ENST00000159060.2	-	9	1055	c.953C>T	c.(952-954)gCg>gTg	p.A318V		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	318	FAD-binding FR-type.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CTGCCCTGGCGCCATTTTAAA	0.542000													9	94					0	0	1	0	0
CUL4A	8451	broad.mit.edu	37	13	113909105	113909105	+	Silent	SNP	G	G	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr13:113909105G>A	ENST00000451881.1	+	17	1800	c.1551G>A	c.(1549-1551)acG>acA	p.T517T	CUL4A_ENST00000375441.3_Silent_p.T517T|CUL4A_ENST00000375440.4_Silent_p.T617T|CUL4A_ENST00000326335.4_Silent_p.T517T	NM_001278513.1|NM_003589.2	NP_001265442.1|NP_003580.1	Q13619	CUL4A_HUMAN	cullin 4A	617					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|skin(1)	17	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			AAATGGCCACGGGGATAGGTA	0.448000													27	55					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	33					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164716358	164716358	+	Nonsense_Mutation	SNP	G	G	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr3:164716358G>A	ENST00000264382.3	-	38	4572	c.4510C>T	c.(4510-4512)Cga>Tga	p.R1504*		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1504	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTGTCCCATCGTGCATAGTTG	0.403000										HNSCC(35;0.089)			20	78					0	0	1	0	0
GPR3	2827	broad.mit.edu	37	1	27720644	27720644	+	Silent	SNP	C	C	T			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr1:27720644C>T	ENST00000374024.3	+	2	441	c.342C>T	c.(340-342)ggC>ggT	p.G114G		NM_005281.3	NP_005272.1	P46089	GPR3_HUMAN	G protein-coupled receptor 3	114					activation of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane				endometrium(3)|lung(3)|ovary(1)|skin(1)	8		Breast(348;1.53e-05)|Ovarian(437;0.0606)|all_lung(284;0.157)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;2.81e-26)|Colorectal(126;1.24e-08)|KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;4.45e-06)|Lung(427;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|LUSC - Lung squamous cell carcinoma(448;0.008)|READ - Rectum adenocarcinoma(331;0.0419)		TGCTGGTTGGCGTGCTGGCAA	0.602000													16	70					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2427341	2427341	+	Missense_Mutation	SNP	T	T	G			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr11:2427341T>G	ENST00000533060.1	-	22	3261	c.3256A>C	c.(3256-3258)Acc>Ccc	p.T1086P	TRPM5_ENST00000528453.1_Intron|TRPM5_ENST00000155858.6_Intron|TRPM5_ENST00000452833.1_Intron|AC124057.5_ENST00000433035.1_RNA			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	1083						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GAGCAGGTGGTCAGGCTGTGG	0.637000													5	23					0	0	1	0	0
NOX4	50507	broad.mit.edu	37	11	89070616	89070616	+	Splice_Site	SNP	T	T	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr11:89070616T>A	ENST00000535633.1	-	16	1752	c.1442A>T	c.(1441-1443)cAg>cTg	p.Q481L	NOX4_ENST00000343727.5_Splice_Site_p.Q481L|NOX4_ENST00000532825.1_Splice_Site_p.Q441L|NOX4_ENST00000534731.1_Splice_Site_p.Q465L|NOX4_ENST00000527956.1_Splice_Site_p.Q481L|NOX4_ENST00000531342.1_Splice_Site_p.Q158L|NOX4_ENST00000413594.2_Splice_Site_p.Q526L|NOX4_ENST00000375979.3_Splice_Site_p.Q198L|NOX4_ENST00000424319.1_Splice_Site_p.Q481L|NOX4_ENST00000525196.1_Splice_Site_p.Q269L|NOX4_ENST00000527626.1_Splice_Site_p.Q318L|NOX4_ENST00000542487.1_Splice_Site_p.Q481L|NOX4_ENST00000263317.4_Splice_Site_p.Q505L|NOX4_ENST00000528341.1_Splice_Site_p.Q480L	NM_001143836.1|NM_016931.3	NP_001137308.1|NP_058627.1	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4	505	Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				ACCACATACCTGTATCCCATC	0.408000													3	49					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48388029	48388029	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr10:48388029T>C	ENST00000224600.4	-	1	2962	c.2849A>G	c.(2848-2850)gAt>gGt	p.D950G		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	950	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GGCATAGTTATCAGCCACCAG	0.627000													20	38					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	229890709	229890709	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr2:229890709G>A	ENST00000392054.3	-	4	725	c.386C>T	c.(385-387)cCg>cTg	p.P129L	PID1_ENST00000392055.3_Missense_Mutation_p.P98L|PID1_ENST00000482518.2_Intron|PID1_ENST00000354069.6_Missense_Mutation_p.P131L|PID1_ENST00000409462.1_Missense_Mutation_p.P49L	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	131	PID.					cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		GGCATTGGCCGGAAAGACATC	0.547000													3	43					0	0	1	0	0
MALAT1	0	broad.mit.edu	37	11	65266350	65266350	+	RNA	SNP	C	C	T			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr11:65266350C>T	ENST00000534336.1	+	0	1118					NR_002819.2																						AGTTTGCATTCAAGTTCCATA	0.348000													6	56					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125262091	125262091	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr2:125262091G>A	ENST00000431078.1	+	8	1646	c.1282G>A	c.(1282-1284)Gtg>Atg	p.V428M		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	428	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		CCTGAGACTCGTGATTCAGAA	0.507000													6	45					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3240659	3240659	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chrX:3240659T>C	ENST00000217939.6	-	5	3221	c.3067A>G	c.(3067-3069)Ata>Gta	p.I1023V		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1023						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGTTCCCCTATAGTAGAATCC	0.448000													45	26					0	0	1	0	0
AC007092.1	0	broad.mit.edu	37	2	58687297	58687298	+	RNA	INS	-	-	T	rs142388743	by1000genomes	TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr2:58687297_58687298insT	ENST00000452840.1	+	0	127																											ATCTGTGTTTCTTTTTTTTTTC	0.312													2	4	---	---	---	---					
DNM1P47	0	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-V1-A8X3-01A-11D-A377-08	TCGA-V1-A8X3-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59cd7fc8-c912-417b-9d55-f0b4918823bb	e25c2cff-eb3c-4e65-8ecd-4e2bf1395062	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													2	4	---	---	---	---					
