Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FRG1B	0	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	G	A	rs145412486	by1000genomes	TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr20:29628236G>A	ENST00000278882.3	+	6	618	c.238G>A	c.(238-240)Gct>Act	p.A80T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A80T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A85T														p.A80P(8)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGGAAAATGGCTTTGTTGGC	0.363000													5	82					0	0	1	0	0
MST1L	0	broad.mit.edu	37	1	17085006	17085006	+	RNA	SNP	C	C	T	rs147678325	by1000genomes	TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr1:17085006C>T	ENST00000455405.2	-	0	182																											CGGATGGCCCCCAGCCACGCG	0.607000													7	43					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537905	55537905	+	Missense_Mutation	SNP	A	A	C			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr8:55537905A>C	ENST00000220676.1	+	4	1611	c.1463A>C	c.(1462-1464)gAa>gCa	p.E488A		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	488					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TATAGTGAAGAAAGGGAAAGT	0.363000													16	28					0	0	1	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254037	39254037	+	Silent	SNP	G	G	A	rs141299737	by1000genomes	TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr17:39254037G>A	ENST00000333822.4	-	1	356	c.300C>T	c.(298-300)tgC>tgT	p.C100C		NM_031960.2	NP_114166.1	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4-8	100	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament				endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)	11						agctggggcggcagcagctgg	0.662000													3	16					0	0	1	0	0
GPAT2	150763	broad.mit.edu	37	2	96689180	96689180	+	Silent	SNP	G	G	A			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr2:96689180G>A	ENST00000434632.1	-	19	2364	c.1905C>T	c.(1903-1905)ggC>ggT	p.G635G	GPAT2_ENST00000359548.4_Silent_p.G635G|GPAT2_ENST00000453542.1_Silent_p.G564G|GPAT2_ENST00000377137.3_Intron			Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2, mitochondrial	635					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(5)|skin(3)	16						CTGGCCGGGAGCCTGGGGTCT	0.567000													6	38					0	0	1	0	0
L3HYPDH	112849	broad.mit.edu	37	14	59942682	59942682	+	Missense_Mutation	SNP	C	C	T			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr14:59942682C>T	ENST00000247194.4	-	4	957	c.844G>A	c.(844-846)Gcc>Acc	p.A282T	L3HYPDH_ENST00000487285.1_Missense_Mutation_p.A111T	NM_144581.1	NP_653182.1			L-3-hydroxyproline dehydratase (trans-)																		TACTGTAAGGCAATTCGGGCT	0.458000													19	25					0	0	1	0	0
PSG3	5671	broad.mit.edu	37	19	43237164	43237164	+	Missense_Mutation	SNP	C	C	T			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr19:43237164C>T	ENST00000327495.5	-	3	665	c.481G>A	c.(481-483)Gac>Aac	p.D161N	PSG3_ENST00000595140.1_Missense_Mutation_p.D161N	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	161	Ig-like C2-type 1.				defense response|female pregnancy	extracellular region		p.D161N(1)		central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				GCCTCCATGTCCTCCCTGGGG	0.537000													4	126					0	0	1	0	0
IL36B	27177	broad.mit.edu	37	2	113783764	113783764	+	Missense_Mutation	SNP	G	G	T			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr2:113783764G>T	ENST00000259213.4	-	5	414	c.307C>A	c.(307-309)Cta>Ata	p.L103I		NM_014438.3	NP_055253.2	Q9NZH7	IL36B_HUMAN	interleukin 36, beta	103					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			kidney(1)|ovary(1)|pancreas(1)	3						attccaactagtttccagcaa	0.463000													18	29					8.34094e-07	8.7918e-07	1	1	0
CDH23	64072	broad.mit.edu	37	10	73558936	73558936	+	Missense_Mutation	SNP	T	T	C			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr10:73558936T>C	ENST00000224721.6	+	50	7143	c.7138T>C	c.(7138-7140)Tca>Cca	p.S2380P	CDH23_ENST00000475158.1_3'UTR|CDH23_ENST00000398788.3_Missense_Mutation_p.S135P	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	2375	Cadherin 22.		P -> L (in dbSNP:rs4747195).		calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CGTGAGGGCCTCAGACAACGG	0.572000													15	18					0	0	1	0	0
HIPK4	147746	broad.mit.edu	37	19	40890039	40890039	+	Missense_Mutation	SNP	T	T	G			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr19:40890039T>G	ENST00000291823.2	-	2	757	c.473A>C	c.(472-474)gAc>gCc	p.D158A		NM_144685.3	NP_653286.2	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	158	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	20			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			GGATCCGAAGTCAATCACCTG	0.637000													15	26					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117696254	117696254	+	Missense_Mutation	SNP	C	C	T			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr12:117696254C>T	ENST00000317775.6	-	16	3164	c.2479G>A	c.(2479-2481)Ggc>Agc	p.G827S	NOS1_ENST00000338101.4_Missense_Mutation_p.G827S|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	827	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AAAGCACAGCCGAATTTCTGG	0.507000													11	17					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73558937	73558937	+	Nonsense_Mutation	SNP	C	C	A			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr10:73558937C>A	ENST00000224721.6	+	50	7144	c.7139C>A	c.(7138-7140)tCa>tAa	p.S2380*	CDH23_ENST00000475158.1_3'UTR|CDH23_ENST00000398788.3_Nonsense_Mutation_p.S135*	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	2375	Cadherin 22.		P -> L (in dbSNP:rs4747195).		calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GTGAGGGCCTCAGACAACGGG	0.572000													15	18					4.7546e-09	5.15082e-09	1	1	0
CEP170	9859	broad.mit.edu	37	1	243362462	243362462	+	Silent	SNP	A	A	G			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr1:243362462A>G	ENST00000366542.1	-	7	582	c.531T>C	c.(529-531)taT>taC	p.Y177Y	CEP170_ENST00000366544.1_Silent_p.Y177Y|CEP170_ENST00000366543.1_Silent_p.Y177Y	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	177						centriole|microtubule|spindle				NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			ACGGCTGCCCATATAATGGAG	0.428000													3	20					0	0	1	0	0
BMPR1A	657	broad.mit.edu	37	10	88676986	88676986	+	Missense_Mutation	SNP	A	A	T			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr10:88676986A>T	ENST00000372037.3	+	9	1308	c.771A>T	c.(769-771)aaA>aaT	p.K257N		NM_004329.2	NP_004320.2	P36894	BMR1A_HUMAN	bone morphogenetic protein receptor, type IA		Protein kinase.				BMP signaling pathway|immune response|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	integral to membrane|plasma membrane	ATP binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|skin(1)|stomach(1)	24						GTGGCGAAAAAGTGGCGGTGA	0.453000			"""Mis, N, F"""			gastrointestinal polyps			Juvenile Polyposis;Hereditary Mixed Polyposis syndrome type 2				8	20					0	0	1	0	0
GPR37L1	9283	broad.mit.edu	37	1	202092723	202092723	+	Splice_Site	SNP	T	T	C			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr1:202092723T>C	ENST00000367282.5	+	1	736		c.e1+2			NM_004767.3	NP_004758.3	O60883	ETBR2_HUMAN	G protein-coupled receptor 37 like 1							integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)	18						TTCATGGAGGTGAGTGTGTGT	0.512000													17	28					0	0	1	0	0
XPC	7508	broad.mit.edu	37	3	14200281	14200281	+	Missense_Mutation	SNP	G	G	T			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr3:14200281G>T	ENST00000285021.7	-	9	1316	c.1102C>A	c.(1102-1104)Caa>Aaa	p.Q368K	XPC_ENST00000449060.2_Missense_Mutation_p.Q331K	NM_001145769.1|NM_004628.4	NP_001139241.1|NP_004619.3	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	368	Lys-rich (basic).				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GTTTCCTCTTGTTTGGTTCCT	0.517000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				16	32					3.52763e-06	3.52763e-06	1	1	0
ADAM21P1	0	broad.mit.edu	37	14	70713782	70713782	+	RNA	SNP	A	A	G	rs114580810	by1000genomes	TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr14:70713782A>G	ENST00000530196.1	-	0	736					NR_003951.1																						GTCACCAGCAAATTTTGGTTC	0.443000													4	51					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130278687	130278687	+	Missense_Mutation	SNP	G	G	T			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr11:130278687G>T	ENST00000257359.6	-	7	2605	c.1899C>A	c.(1897-1899)agC>agA	p.S633R		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	633	Cys-rich.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		CTTTGAACTCGCTCCTCCCCC	0.642000													30	72					1.74807e-11	1.94785e-11	1	1	0
ELF4	2000	broad.mit.edu	37	X	129208569	129208569	+	Missense_Mutation	SNP	A	A	C			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chrX:129208569A>C	ENST00000308167.5	-	3	613	c.234T>G	c.(232-234)agT>agG	p.S78R	ELF4_ENST00000335997.7_Missense_Mutation_p.S78R	NM_001421.3	NP_001412.1	Q99607	ELF4_HUMAN	E74-like factor 4 (ets domain transcription factor)	78					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	22						TCAGCAAAAAACTGCCTTCCA	0.517000			T	ERG	AML								23	5					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8460280	8460280	+	Splice_Site	SNP	T	T	C			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr9:8460280T>C	ENST00000537002.1	-	16	2736	c.2634A>G	c.(2632-2634)agA>agG	p.R878R	PTPRD_ENST00000381196.4_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000540109.1_Intron|PTPRD_ENST00000356435.5_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000360074.4_Intron|PTPRD_ENST00000358503.5_Intron|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000486161.1_Intron			P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1292	Fibronectin type-III 6.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TAAACACTTTTCCAAAAATAA	0.328000										TSP Lung(15;0.13)			6	7					0	0	1	0	0
ZKSCAN7	55888	broad.mit.edu	37	3	44611916	44611916	+	Silent	SNP	C	C	G			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr3:44611916C>G	ENST00000273320.3	+	6	1743	c.1314C>G	c.(1312-1314)ccC>ccG	p.P438P	RP11-944L7.4_ENST00000457331.1_RNA|RP11-944L7.5_ENST00000419137.1_Intron|ZKSCAN7_ENST00000431636.1_Intron|ZKSCAN7_ENST00000426540.1_Silent_p.P438P|ZKSCAN7_ENST00000341840.3_Intron	NM_018651.2	NP_061121.2			zinc finger with KRAB and SCAN domains 7									p.P438P(1)									GGGAAAAACCCTATGAATGCA	0.463000													8	13					0	0	1	0	0
BEST1	7439	broad.mit.edu	37	11	61730330	61730330	+	Missense_Mutation	SNP	A	A	C			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr11:61730330A>C	ENST00000449131.2	+	9	1610	c.1524A>C	c.(1522-1524)aaA>aaC	p.K508N	BEST1_ENST00000378042.3_Missense_Mutation_p.K481N|BEST1_ENST00000378043.4_Missense_Mutation_p.K568N|BEST1_ENST00000301774.9_Missense_Mutation_p.K196N|FTH1_ENST00000529191.1_Intron|BEST1_ENST00000534553.1_3'UTR|FTH1_ENST00000529631.1_Intron	NM_001139443.1	NP_001132915.1	O76090	BEST1_HUMAN	bestrophin 1	568					response to stimulus|transepithelial chloride transport|visual perception	basolateral plasma membrane|chloride channel complex|cytosol|membrane fraction	chloride channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|urinary_tract(2)	25						CTACACTCAAAGATCACATGG	0.502000													10	22					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628268	29628268	+	Missense_Mutation	SNP	A	A	T			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr20:29628268A>T	ENST00000278882.3	+	6	650	c.270A>T	c.(268-270)agA>agT	p.R90S	FRG1B_ENST00000358464.4_Missense_Mutation_p.R90S|FRG1B_ENST00000439954.2_Missense_Mutation_p.R95S																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GCTTTATTAGATGCAATGAAG	0.358000													4	73					0	0	1	0	0
NDE1	54820	broad.mit.edu	37	16	15771720	15771720	+	Silent	SNP	C	C	G			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr16:15771720C>G	ENST00000396355.1	+	5	1126	c.300C>G	c.(298-300)ctC>ctG	p.L100L	NDE1_ENST00000342673.5_Silent_p.L100L|NDE1_ENST00000396354.1_Silent_p.L100L|NDE1_ENST00000396353.2_Silent_p.L100L	NM_001143979.1	NP_001137451.1	Q9NXR1	NDE1_HUMAN	nudE neurodevelopment protein 1	100	Interaction with PAFAH1B1 (By similarity).				cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding	p.L100L(1)		endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13						AGGATGACCTCGCGCAGACCA	0.498000													10	9					0	0	1	0	0
COL17A1	1308	broad.mit.edu	37	10	105832989	105832989	+	Nonsense_Mutation	SNP	T	T	A			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr10:105832989T>A	ENST00000353479.5	-	7	684	c.394A>T	c.(394-396)Aga>Tga	p.R132*	COL17A1_ENST00000369733.3_Nonsense_Mutation_p.R132*|COL17A1_ENST00000393211.3_Nonsense_Mutation_p.R132*	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	132	Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CTCCGTCCTCTGGTTGAAGAA	0.418000													7	159					0	0	1	0	0
C20orf194	25943	broad.mit.edu	37	20	3274852	3274852	+	Missense_Mutation	SNP	C	C	T	rs149733245	by1000genomes	TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr20:3274852C>T	ENST00000252032.9	-	25	2238	c.2171G>A	c.(2170-2172)cGg>cAg	p.R724Q	C20orf194_ENST00000453730.2_Missense_Mutation_p.R462Q	NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194	724										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						AAGATGGGTCCGCATCACAGG	0.468000													4	28					0	0	1	0	0
USP12	219333	broad.mit.edu	37	13	27745742	27745742	+	Missense_Mutation	SNP	G	G	A			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr13:27745742G>A	ENST00000282344.6	-	1	291	c.35C>T	c.(34-36)tCc>tTc	p.S12F		NM_182488.3	NP_872294.2	O75317	UBP12_HUMAN	ubiquitin specific peptidase 12	12					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Lung SC(185;0.0161)		all cancers(112;0.0508)|GBM - Glioblastoma multiforme(144;0.168)|Epithelial(112;0.244)|OV - Ovarian serous cystadenocarcinoma(117;0.246)		GGTACAGATGGAGGCGAATTT	0.721000													8	7					0	0	1	0	0
ZNF713	349075	broad.mit.edu	37	7	56007346	56007346	+	Missense_Mutation	SNP	T	T	G			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr7:56007346T>G	ENST00000429591.2	+	4	978	c.940T>G	c.(940-942)Tca>Gca	p.S314A	MRPS17_ENST00000426595.1_Intron	NM_182633.1	NP_872439.1	Q8N859	ZN713_HUMAN	zinc finger protein 713	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CCGTCAGCATTCATCCTTTAC	0.403000													40	62					0	0	1	0	0
PDPR	55066	broad.mit.edu	37	16	70187414	70187414	+	Missense_Mutation	SNP	G	G	C			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr16:70187414G>C	ENST00000288050.4	+	18	3130	c.2173G>C	c.(2173-2175)Gat>Cat	p.D725H	PDPR_ENST00000568530.1_Missense_Mutation_p.D725H|PDPR_ENST00000567046.1_Missense_Mutation_p.D83H|PDPR_ENST00000542659.1_Missense_Mutation_p.D70H|PDPR_ENST00000562100.1_Intron|PDPR_ENST00000398122.3_Missense_Mutation_p.D625H	NM_017990.3	NP_060460.4	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory subunit	725					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		CTGGGGTCAGGATATAAATAA	0.478000													5	8					0	0	1	0	0
SPOP	8405	broad.mit.edu	37	17	47696450	47696450	+	Missense_Mutation	SNP	A	A	G			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr17:47696450A>G	ENST00000393331.3	-	7	843	c.373T>C	c.(373-375)Ttt>Ctt	p.F125L	SPOP_ENST00000504102.1_Missense_Mutation_p.F125L|SPOP_ENST00000347630.2_Missense_Mutation_p.F125L|SPOP_ENST00000503676.1_Missense_Mutation_p.F125L|SPOP_ENST00000393328.2_Missense_Mutation_p.F125L	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	125	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.F125V(1)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						CCTTGCACAAACCTATATGCC	0.433000										Prostate(2;0.17)			36	46					0	0	1	0	0
C19orf24	55009	broad.mit.edu	37	19	1279101	1279101	+	Missense_Mutation	SNP	C	C	T			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr19:1279101C>T	ENST00000469144.1	+	3	601	c.292C>T	c.(292-294)Ctc>Ttc	p.L98F	C19orf24_ENST00000409293.4_3'UTR			Q9BVV8	CS024_HUMAN	chromosome 19 open reading frame 24	39						cytoplasm|extracellular region part|integral to membrane							Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000332)|all_lung(49;0.000498)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGACTTGTGCCTCTCTCCTGC	0.667000													16	34					0	0	1	0	0
DAAM1	23002	broad.mit.edu	37	14	59797408	59797408	+	Splice_Site	SNP	T	T	C			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr14:59797408T>C	ENST00000395125.1	+	12	1583		c.e12+2		DAAM1_ENST00000360909.3_Splice_Site|DAAM1_ENST00000351081.1_Splice_Site	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1						actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		CTCAGCAGGGTGAGGTCTTCC	0.512000													9	10					0	0	1	0	0
PABPC3	5042	broad.mit.edu	37	13	25671849	25671849	+	Missense_Mutation	SNP	C	C	T			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr13:25671849C>T	ENST00000281589.3	+	1	1550	c.1513C>T	c.(1513-1515)Cgg>Tgg	p.R505W		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	505					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CACGGTTCCACGGTATAAATA	0.532000													21	27					0	0	1	0	0
RRP9	9136	broad.mit.edu	37	3	51972181	51972183	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr3:51972181_51972183delCTC	ENST00000232888.6	-	3	281_283	c.208_210delGAG	c.(208-210)gagdel	p.E70del		NM_004704.3	NP_004695.1	O43818	U3IP2_HUMAN	ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)	70	Glu-rich.				rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|ovary(1)|skin(1)	21				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)		TTtcctccagctcctcctcctcc	0.616													2	4	---	---	---	---					
CCT6P3	0	broad.mit.edu	37	7	64528813	64528814	+	RNA	INS	-	-	T			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr7:64528813_64528814insT	ENST00000426828.1	+	0	621					NR_033416.1																						CTTTCTGTAACTTTTTTTTTTT	0.317													3	3	---	---	---	---					
PCNXL3	399909	broad.mit.edu	37	11	65385547	65385547	+	Frame_Shift_Del	DEL	C	C	-			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr11:65385547delC	ENST00000355703.3	+	6	1253	c.714delC	c.(712-714)agcfs	p.S238fs		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	238						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CTCCCATGAGCCCCCTGCTGA	0.642													2	4	---	---	---	---					
PACS1	55690	broad.mit.edu	37	11	65838130	65838130	+	Frame_Shift_Del	DEL	C	C	-			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr11:65838130delC	ENST00000320580.4	+	1	206	c.173delC	c.(172-174)tcgfs	p.S59fs		NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	59	Ser-rich.				interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						TCGTCGTCCTCGTCCACCTCG	0.766													2	4	---	---	---	---					
LEPREL2	10536	broad.mit.edu	37	12	6946538	6946538	+	RNA	DEL	C	C	-			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr12:6946538delC	ENST00000251761.8	+	0	1593				LEPREL2_ENST00000606935.1_RNA|LEPREL2_ENST00000396725.2_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						GCCGAGACCACCCTCCCCTTG	0.627													2	4	---	---	---	---					
ZFHX3	463	broad.mit.edu	37	16	72828649	72828650	+	Frame_Shift_Ins	INS	-	-	A			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr16:72828649_72828650insA	ENST00000268489.5	-	9	8603_8604	c.7931_7932insT	c.(7930-7932)ttgfs	p.L2644fs	ZFHX3_ENST00000397992.5_Frame_Shift_Ins_p.L1730fs	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	2644					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				TGGTTGTTCTCAAACGCTTGTC	0.490													7	194	---	---	---	---					
ERBB2	2064	broad.mit.edu	37	17	37872561	37872561	+	Frame_Shift_Del	DEL	G	G	-			TCGA-VN-A88R-01A-11D-A364-08	TCGA-VN-A88R-10B-01D-A362-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d624f520-0cf2-479f-a434-493117b54ed0	f3aa6d62-dfca-43e4-8c16-a07c4a3ad3e9	g.chr17:37872561delG	ENST00000406381.2	+	15	1941	c.1431delG	c.(1429-1431)gagfs	p.E477fs	ERBB2_ENST00000578199.1_Frame_Shift_Del_p.E477fs|ERBB2_ENST00000540042.1_Frame_Shift_Del_p.E477fs|ERBB2_ENST00000584601.1_Frame_Shift_Del_p.E477fs|ERBB2_ENST00000584450.1_Frame_Shift_Del_p.E507fs|ERBB2_ENST00000269571.5_Frame_Shift_Del_p.E507fs|ERBB2_ENST00000541774.1_Frame_Shift_Del_p.E492fs|ERBB2_ENST00000445658.2_Frame_Shift_Del_p.E231fs|ERBB2_ENST00000540147.1_Frame_Shift_Del_p.E477fs	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	507					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CAGTGGGCGAGGGCCTGGCCT	0.677		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			2	4	---	---	---	---					
