#version 2.4
## 
## Oncotator v1.8.0.0 | Flat File Reference hg19 | GENCODE v19 EFFECT | UniProt_AAxform 2014_12 | ClinVar 12.03.20 | ESP 6500SI-V2 | ORegAnno UCSC Track | dbSNP build 142 | CCLE_By_GP 09292010 | COSMIC v62_291112 | 1000gp3 20130502 | UniProt_AA 2014_12 | dbNSFP v2.4 | ESP 6500SI-V2 | COSMIC_FusionGenes v62_291112 | gencode_xref_refseq metadata_v19 | CCLE_By_Gene 09292010 | ACHILLES_Lineage_Results 110303 | CGC full_2012-03-15 | UniProt 2014_12 | HumanDNARepairGenes 20110905 | HGNC Sept172014 | COSMIC_Tissue 291112 | Familial_Cancer_Genes 20110905 | TUMORScape 20100104 | Ensembl ICGC MUCOPA | TCGAScape 110405 | MutSig Published Results 20110905 
Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	i_1000gp3_AA	i_1000gp3_AC	i_1000gp3_AF	i_1000gp3_AFR_AF	i_1000gp3_AMR_AF	i_1000gp3_AN	i_1000gp3_CIEND	i_1000gp3_CIPOS	i_1000gp3_CS	i_1000gp3_DP	i_1000gp3_EAS_AF	i_1000gp3_END	i_1000gp3_EUR_AF	i_1000gp3_IMPRECISE	i_1000gp3_MC	i_1000gp3_MEINFO	i_1000gp3_MEND	i_1000gp3_MLEN	i_1000gp3_MSTART	i_1000gp3_NS	i_1000gp3_SAS_AF	i_1000gp3_SVLEN	i_1000gp3_SVTYPE	i_1000gp3_TSD	i_ACHILLES_Lineage_Results_Top_Genes	i_BAM_File	i_CGC_Cancer Germline Mut	i_CGC_Cancer Molecular Genetics	i_CGC_Cancer Somatic Mut	i_CGC_Cancer Syndrome	i_CGC_Chr	i_CGC_Chr Band	i_CGC_GeneID	i_CGC_Name	i_CGC_Other Germline Mut	i_CGC_Tissue Type	i_COSMIC_n_overlapping_mutations	i_COSMIC_overlapping_mutation_descriptions	i_COSMIC_overlapping_primary_sites	i_ClinVar_ASSEMBLY	i_ClinVar_HGMD_ID	i_ClinVar_SYM	i_ClinVar_TYPE	i_ClinVar_rs	i_ESP_AA	i_ESP_AAC	i_ESP_AA_AC	i_ESP_AA_AGE	i_ESP_AA_GTC	i_ESP_AvgAAsampleReadDepth	i_ESP_AvgEAsampleReadDepth	i_ESP_AvgSampleReadDepth	i_ESP_CA	i_ESP_CDP	i_ESP_CG	i_ESP_CP	i_ESP_Chromosome	i_ESP_DBSNP	i_ESP_DP	i_ESP_EA_AC	i_ESP_EA_AGE	i_ESP_EA_GTC	i_ESP_EXOME_CHIP	i_ESP_FG	i_ESP_GL	i_ESP_GM	i_ESP_GS	i_ESP_GTC	i_ESP_GTS	i_ESP_GWAS_PUBMED	i_ESP_MAF	i_ESP_PH	i_ESP_PP	i_ESP_Position	i_ESP_TAC	i_ESP_TotalAAsamplesCovered	i_ESP_TotalEAsamplesCovered	i_ESP_TotalSamplesCovered	i_EVS_AA	i_EVS_All	i_EVS_EA	i_Ensembl_so_accession	i_Ensembl_so_term	i_Entrez_Gene_Id	i_Familial_Cancer_Genes_Reference	i_Familial_Cancer_Genes_Synonym	i_HGNC_Accession Numbers	i_HGNC_CCDS IDs	i_HGNC_Chromosome	i_HGNC_Date Modified	i_HGNC_Date Name Changed	i_HGNC_Date Symbol Changed	i_HGNC_Ensembl Gene ID	i_HGNC_Ensembl ID(supplied by Ensembl)	i_HGNC_Enzyme IDs	i_HGNC_Gene family description	i_HGNC_HGNC ID	i_HGNC_Locus Group	i_HGNC_Locus Type	i_HGNC_Name Synonyms	i_HGNC_OMIM ID(supplied by NCBI)	i_HGNC_Previous Names	i_HGNC_Previous Symbols	i_HGNC_Primary IDs	i_HGNC_Pubmed IDs	i_HGNC_Record Type	i_HGNC_RefSeq(supplied by NCBI)	i_HGNC_Secondary IDs	i_HGNC_Status	i_HGNC_Synonyms	i_HGNC_UCSC ID(supplied by UCSC)	i_HGNC_UniProt ID(supplied by UniProt)	i_HGNC_VEGA IDs	i_HGVS_coding_DNA_change	i_HGVS_genomic_change	i_HGVS_protein_change	i_Mutation_Status	i_ORegAnno_bin	i_Sequence_Source	i_Sequencer	i_Sequencing_Phase	i_UniProt_alt_uniprot_accessions	i_Variant_Classification	i_Variant_Type	i_all_domains_WU	i_amino_acid_change_WU	i_annotation_transcript	i_build	i_c_position_WU	i_ccds_id	i_chromosome_name_WU	i_dbNSFP_1000Gp1_AC	i_dbNSFP_1000Gp1_AF	i_dbNSFP_1000Gp1_AFR_AC	i_dbNSFP_1000Gp1_AFR_AF	i_dbNSFP_1000Gp1_AMR_AC	i_dbNSFP_1000Gp1_AMR_AF	i_dbNSFP_1000Gp1_ASN_AC	i_dbNSFP_1000Gp1_ASN_AF	i_dbNSFP_1000Gp1_EUR_AC	i_dbNSFP_1000Gp1_EUR_AF	i_dbNSFP_Ancestral_allele	i_dbNSFP_CADD_phred	i_dbNSFP_CADD_raw	i_dbNSFP_CADD_raw_rankscore	i_dbNSFP_ESP6500_AA_AF	i_dbNSFP_ESP6500_EA_AF	i_dbNSFP_Ensembl_geneid	i_dbNSFP_Ensembl_transcriptid	i_dbNSFP_FATHMM_pred	i_dbNSFP_FATHMM_rankscore	i_dbNSFP_FATHMM_score	i_dbNSFP_GERP++_NR	i_dbNSFP_GERP++_RS	i_dbNSFP_GERP++_RS_rankscore	i_dbNSFP_Interpro_domain	i_dbNSFP_LRT_Omega	i_dbNSFP_LRT_converted_rankscore	i_dbNSFP_LRT_pred	i_dbNSFP_LRT_score	i_dbNSFP_LR_pred	i_dbNSFP_LR_rankscore	i_dbNSFP_LR_score	i_dbNSFP_MutationAssessor_pred	i_dbNSFP_MutationAssessor_rankscore	i_dbNSFP_MutationAssessor_score	i_dbNSFP_MutationTaster_converted_rankscore	i_dbNSFP_MutationTaster_pred	i_dbNSFP_MutationTaster_score	i_dbNSFP_Polyphen2_HDIV_pred	i_dbNSFP_Polyphen2_HDIV_rankscore	i_dbNSFP_Polyphen2_HDIV_score	i_dbNSFP_Polyphen2_HVAR_pred	i_dbNSFP_Polyphen2_HVAR_rankscore	i_dbNSFP_Polyphen2_HVAR_score	i_dbNSFP_RadialSVM_pred	i_dbNSFP_RadialSVM_rankscore	i_dbNSFP_RadialSVM_score	i_dbNSFP_Reliability_index	i_dbNSFP_SIFT_converted_rankscore	i_dbNSFP_SIFT_pred	i_dbNSFP_SIFT_score	i_dbNSFP_SLR_test_statistic	i_dbNSFP_SiPhy_29way_logOdds	i_dbNSFP_SiPhy_29way_logOdds_rankscore	i_dbNSFP_SiPhy_29way_pi	i_dbNSFP_UniSNP_ids	i_dbNSFP_Uniprot_aapos	i_dbNSFP_Uniprot_acc	i_dbNSFP_Uniprot_id	i_dbNSFP_aaalt	i_dbNSFP_aapos	i_dbNSFP_aapos_FATHMM	i_dbNSFP_aapos_SIFT	i_dbNSFP_aaref	i_dbNSFP_cds_strand	i_dbNSFP_codonpos	i_dbNSFP_fold-degenerate	i_dbNSFP_genename	i_dbNSFP_hg18_pos(1-coor)	i_dbNSFP_phastCons100way_vertebrate	i_dbNSFP_phastCons100way_vertebrate_rankscore	i_dbNSFP_phastCons46way_placental	i_dbNSFP_phastCons46way_placental_rankscore	i_dbNSFP_phastCons46way_primate	i_dbNSFP_phastCons46way_primate_rankscore	i_dbNSFP_phyloP100way_vertebrate	i_dbNSFP_phyloP100way_vertebrate_rankscore	i_dbNSFP_phyloP46way_placental	i_dbNSFP_phyloP46way_placental_rankscore	i_dbNSFP_phyloP46way_primate	i_dbNSFP_phyloP46way_primate_rankscore	i_dbNSFP_refcodon	i_default_gene_name_WU	i_deletion_substructures_WU	i_domain_WU	i_ensembl_gene_id	i_entrez_gene_id	i_gc_content_full	i_gencode_transcript_name	i_gencode_transcript_status	i_gencode_transcript_tags	i_gencode_transcript_type	i_gene_name_WU	i_gene_name_source_WU	i_gene_type	i_havana_transcript	i_normal_ref_reads	i_normal_vaf	i_normal_var_reads	i_reference_WU	i_refseq_mrna_id	i_secondary_variant_classification	i_start_WU	i_stop_WU	i_strand_WU	i_transcript_error_WU	i_transcript_name_WU	i_transcript_source_WU	i_transcript_species_WU	i_transcript_status_WU	i_transcript_version_WU	i_trv_type_WU	i_tumor_ref_reads	i_tumor_vaf	i_tumors_var_reads	i_type_WU	i_ucsc_cons_WU	i_variant_WU
ATF3	467	genome.wustl.edu	37	1	212792849	212792849	+	Missense_Mutation	SNP	G	G	C			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	G	G					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chr1:212792849G>C	ENST00000341491.4	+	4	763	c.498G>C	c.(496-498)gaG>gaC	p.E166D	ATF3_ENST00000366983.1_3'UTR|ATF3_ENST00000492118.1_3'UTR|ATF3_ENST00000366987.2_Missense_Mutation_p.E166D|ATF3_ENST00000366985.1_Missense_Mutation_p.E109D	NM_001040619.2|NM_001206488.2|NM_001674.3	NP_001035709.1|NP_001193417.2|NP_001665.1	P18847	ATF3_HUMAN	activating transcription factor 3	166					activation of signaling protein activity involved in unfolded protein response (GO:0006987)|cellular protein metabolic process (GO:0044267)|endoplasmic reticulum unfolded protein response (GO:0030968)|gluconeogenesis (GO:0006094)|positive regulation of cell proliferation (GO:0008284)|positive regulation of transcription from RNA polymerase II promoter (GO:0045944)|skeletal muscle cell differentiation (GO:0035914)	nucleolus (GO:0005730)|nucleoplasm (GO:0005654)|nucleus (GO:0005634)	identical protein binding (GO:0042802)|RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription (GO:0001078)|RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228)|sequence-specific DNA binding transcription factor activity (GO:0003700)|transcription corepressor activity (GO:0003714)			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	6				OV - Ovarian serous cystadenocarcinoma(81;0.00628)|all cancers(67;0.0097)|GBM - Glioblastoma multiforme(131;0.0388)|Epithelial(68;0.0933)	Pseudoephedrine(DB00852)	CAGAAGATGAGAGAAACCTCT	0.473																																						dbGAP											0													70.0	65.0	66.0					1																	212792849		2203	4300	6503	-	-	-	SO:0001583	missense	0			L19871	CCDS1506.1, CCDS41464.1, CCDS55688.1, CCDS58059.1	1q32.3	2013-01-10			ENSG00000162772	ENSG00000162772		"""basic leucine zipper proteins"""	785	protein-coding gene	gene with protein product		603148				7515060	Standard	NM_001674		Approved		uc021pit.1	P18847	OTTHUMG00000036747	ENST00000341491.4:c.498G>C	1.37:g.212792849G>C	ENSP00000344352:p.Glu166Asp	Somatic		WXS	Illumina GAIIx	Phase_IV	Q5VTZ2|Q6ICQ9|Q7Z566|Q8WYM6	Missense_Mutation	SNP	pfam_bZIP_1,pfam_bZIP_2,superfamily_Euk_TF_DNA-bd,smart_bZIP,pfscan_bZIP,prints_Leuzip_Fos	p.E166D	ENST00000341491.4	37	c.498	CCDS1506.1	1	.	.	.	.	.	.	.	.	.	.	G	21.0	4.082017	0.76528	.	.	ENSG00000162772	ENST00000366981;ENST00000366987;ENST00000341491;ENST00000366985	T;T;T;T	0.66815	0.25;0.31;0.31;-0.23	6.17	2.29	0.28610	.	0.000000	0.85682	D	0.000000	T	0.68393	0.2996	L	0.32530	0.975	0.80722	D	1	D	0.63880	0.993	D	0.70016	0.967	T	0.64655	-0.6356	10	0.42905	T	0.14	-2.1661	8.8099	0.34961	0.4219:0.0:0.5781:0.0	.	166	P18847	ATF3_HUMAN	D	166;166;166;109	ENSP00000355948:E166D;ENSP00000355954:E166D;ENSP00000344352:E166D;ENSP00000355952:E109D	ENSP00000344352:E166D	E	+	3	2	ATF3	210859472	1.000000	0.71417	1.000000	0.80357	0.998000	0.95712	2.807000	0.47955	0.491000	0.27793	0.655000	0.94253	GAG	ATF3	-	NULL	ENSG00000162772		0.473	ATF3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	ATF3	HGNC	protein_coding	OTTHUMT00000089296.1	100	0.00	0	G	NM_001674		212792849	212792849	+1	no_errors	ENST00000341491	ensembl	human	known	69_37n	missense	152	11.63	20	SNP	1.000	C
BCORL1	63035	genome.wustl.edu	37	X	129189983	129189983	+	Missense_Mutation	SNP	G	G	A			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	G	G					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chrX:129189983G>A	ENST00000218147.7	+	13	5205	c.5008G>A	c.(5008-5010)Gag>Aag	p.E1670K	BCORL1_ENST00000359304.2_Missense_Mutation_p.E1540K|BCORL1_ENST00000303743.5_Missense_Mutation_p.E1744K|BCORL1_ENST00000540052.1_Missense_Mutation_p.E1670K			Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1670					chromatin modification (GO:0016568)|regulation of transcription, DNA-templated (GO:0006355)|transcription, DNA-templated (GO:0006351)	cytoplasm (GO:0005737)|nucleus (GO:0005634)|plasma membrane (GO:0005886)				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GACCCCTGCCGAGAGGCCTGG	0.627																																						dbGAP											0													63.0	63.0	63.0					X																	129189983		2203	4300	6503	-	-	-	SO:0001583	missense	0			AL136450	CCDS14616.1	Xq25-q26.1	2014-09-17	2010-06-10		ENSG00000085185	ENSG00000085185		"""Ankyrin repeat domain containing"""	25657	protein-coding gene	gene with protein product		300688	"""chromosome X open reading frame 10"", ""BCL6 co-repressor-like 1"""	CXorf10			Standard	NM_021946		Approved	FLJ11362	uc022cdu.1	Q5H9F3	OTTHUMG00000022379	ENST00000218147.7:c.5008G>A	X.37:g.129189983G>A	ENSP00000218147:p.Glu1670Lys	Somatic		WXS	Illumina GAIIx	Phase_IV	B5MDQ8|Q5H9F2|Q5H9F4|Q6ZVE0|Q8TEN3|Q9Y528	Missense_Mutation	SNP	pfam_Ankyrin_rpt,superfamily_Ankyrin_rpt-contain_dom,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom	p.E1744K	ENST00000218147.7	37	c.5230	CCDS14616.1	X	.	.	.	.	.	.	.	.	.	.	g	19.33	3.806693	0.70682	.	.	ENSG00000085185	ENST00000218147;ENST00000303743;ENST00000359304;ENST00000540052;ENST00000456822	T;T;T;T;T	0.39592	1.07;1.37;1.07;1.07;1.43	4.57	4.57	0.56435	.	0.000000	0.34959	N	0.003555	T	0.52853	0.1760	L	0.38175	1.15	0.53005	D	0.999965	D;P	0.89917	1.0;0.939	D;P	0.79108	0.992;0.452	T	0.44544	-0.9321	10	0.21014	T	0.42	-20.7382	16.6738	0.85273	0.0:0.0:1.0:0.0	.	1744;1670	Q5H9F3-3;Q5H9F3	.;BCORL_HUMAN	K	1670;1744;1540;1670;1344	ENSP00000218147:E1670K;ENSP00000307541:E1744K;ENSP00000352253:E1540K;ENSP00000437775:E1670K;ENSP00000399483:E1344K	ENSP00000218147:E1670K	E	+	1	0	BCORL1	129017664	1.000000	0.71417	0.900000	0.35374	0.617000	0.37484	5.530000	0.67141	2.109000	0.64355	0.509000	0.49947	GAG	BCORL1	-	NULL	ENSG00000085185		0.627	BCORL1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	BCORL1	HGNC	protein_coding	OTTHUMT00000058223.1	67	0.00	0	G	NM_021946		129189983	129189983	+1	no_errors	ENST00000303743	ensembl	human	known	69_37n	missense	53	25.35	18	SNP	0.999	A
CCDC24	149473	genome.wustl.edu	37	1	44458238	44458238	+	Missense_Mutation	SNP	C	C	T			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	C	C					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chr1:44458238C>T	ENST00000372318.3	+	4	517	c.346C>T	c.(346-348)Cac>Tac	p.H116Y	SLC6A9_ENST00000372307.3_Intron|SLC6A9_ENST00000372306.3_Intron|CCDC24_ENST00000479055.1_3'UTR	NM_152499.1	NP_689712.1	Q8N4L8	CCD24_HUMAN	coiled-coil domain containing 24	116										endometrium(3)|large_intestine(2)|lung(3)|stomach(1)	9	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CAGGGTCCTGCACTTTGCCTT	0.557																																						dbGAP											0													97.0	90.0	92.0					1																	44458238		2203	4300	6503	-	-	-	SO:0001583	missense	0				CCDS507.1	1p34.1	2008-02-05			ENSG00000159214	ENSG00000159214			28688	protein-coding gene	gene with protein product						12477932	Standard	NM_152499		Approved	MGC45441	uc001clj.3	Q8N4L8	OTTHUMG00000008299	ENST00000372318.3:c.346C>T	1.37:g.44458238C>T	ENSP00000361392:p.His116Tyr	Somatic		WXS	Illumina GAIIx	Phase_IV	Q6RWT2	Missense_Mutation	SNP	NULL	p.H116Y	ENST00000372318.3	37	c.346	CCDS507.1	1	.	.	.	.	.	.	.	.	.	.	C	16.55	3.153300	0.57259	.	.	ENSG00000159214	ENST00000372318	.	.	.	4.92	4.92	0.64577	.	0.435762	0.22583	N	0.058197	T	0.45357	0.1338	N	0.22421	0.69	0.80722	D	1	P;P;P	0.52316	0.952;0.775;0.775	P;B;B	0.47075	0.536;0.341;0.342	T	0.45205	-0.9277	9	0.48119	T	0.1	-18.603	13.5951	0.61984	0.0:1.0:0.0:0.0	.	80;72;116	Q8N4L8-2;Q05BG8;Q8N4L8	.;.;CCD24_HUMAN	Y	116	.	ENSP00000361392:H116Y	H	+	1	0	CCDC24	44230825	0.986000	0.35501	0.999000	0.59377	0.951000	0.60555	3.711000	0.54868	2.263000	0.75096	0.313000	0.20887	CAC	CCDC24	-	NULL	ENSG00000159214		0.557	CCDC24-001	KNOWN	basic|appris_principal|CCDS	protein_coding	CCDC24	HGNC	protein_coding	OTTHUMT00000022865.1	336	0.00	0	C	NM_152499		44458238	44458238	+1	no_errors	ENST00000372318	ensembl	human	known	69_37n	missense	304	28.30	120	SNP	0.998	T
COL24A1	255631	genome.wustl.edu	37	1	86591291	86591291	+	Missense_Mutation	SNP	C	C	T	rs200728036		TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	C	C					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chr1:86591291C>T	ENST00000370571.2	-	3	1094	c.728G>A	c.(727-729)cGc>cAc	p.R243H	COL24A1_ENST00000436319.1_Missense_Mutation_p.R243H	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	243					extracellular matrix organization (GO:0030198)|hematopoietic progenitor cell differentiation (GO:0002244)	collagen trimer (GO:0005581)|endoplasmic reticulum lumen (GO:0005788)|extracellular region (GO:0005576)|proteinaceous extracellular matrix (GO:0005578)	extracellular matrix structural constituent (GO:0005201)	p.R243H(1)		NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		GTCTGCTTGGCGACACTGCTG	0.408																																						dbGAP											1	Substitution - Missense(1)	large_intestine(1)											77.0	76.0	76.0					1																	86591291		2007	4177	6184	-	-	-	SO:0001583	missense	0			AF410793	CCDS41353.1	1p22.3-p22.2	2013-01-16			ENSG00000171502	ENSG00000171502		"""Collagens"""	20821	protein-coding gene	gene with protein product		610025					Standard	NM_152890		Approved		uc001dlj.3	Q17RW2	OTTHUMG00000010629	ENST00000370571.2:c.728G>A	1.37:g.86591291C>T	ENSP00000359603:p.Arg243His	Somatic		WXS	Illumina GAIIx	Phase_IV	C9J1X6|Q14BD7|Q59EX5|Q5VY50|Q7Z5L5	Missense_Mutation	SNP	pfam_Collagen,pfam_Fib_collagen_C,pfam_Laminin_G,superfamily_ConA-like_lec_gl,smart_Laminin_G,smart_Fib_collagen_C	p.R243H	ENST00000370571.2	37	c.728	CCDS41353.1	1	.	.	.	.	.	.	.	.	.	.	C	4.517	0.095952	0.08681	.	.	ENSG00000171502	ENST00000370571;ENST00000436319	T;T	0.17370	2.28;2.28	5.69	-6.66	0.01789	Concanavalin A-like lectin/glucanase (1);	0.742942	0.11102	N	0.599537	T	0.03011	0.0089	L	0.46157	1.445	0.18873	N	0.999989	B;B	0.25007	0.116;0.004	B;B	0.17098	0.017;0.002	T	0.28681	-1.0036	10	0.49607	T	0.09	.	1.9009	0.03267	0.4755:0.1764:0.0936:0.2546	.	243;243	F8WDM8;Q17RW2	.;COOA1_HUMAN	H	243	ENSP00000359603:R243H;ENSP00000392531:R243H	ENSP00000359603:R243H	R	-	2	0	COL24A1	86363879	0.001000	0.12720	0.006000	0.13384	0.359000	0.29487	-0.379000	0.07437	-1.898000	0.01100	-0.309000	0.09137	CGC	COL24A1	-	superfamily_ConA-like_lec_gl	ENSG00000171502		0.408	COL24A1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	COL24A1	HGNC	protein_coding	OTTHUMT00000029335.4	147	0.00	0	C	NM_152890		86591291	86591291	-1	no_errors	ENST00000370571	ensembl	human	known	69_37n	missense	103	30.41	45	SNP	0.069	T
HCFC1	3054	genome.wustl.edu	37	X	153219074	153219074	+	Missense_Mutation	SNP	G	G	A			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	G	G					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chrX:153219074G>A	ENST00000310441.7	-	18	5447	c.4481C>T	c.(4480-4482)cCg>cTg	p.P1494L	HCFC1_ENST00000369984.4_Missense_Mutation_p.P1494L|HCFC1_ENST00000354233.3_Missense_Mutation_p.P1425L	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1	1494					cell cycle (GO:0007049)|chromatin organization (GO:0006325)|histone H4-K16 acetylation (GO:0043984)|histone H4-K5 acetylation (GO:0043981)|histone H4-K8 acetylation (GO:0043982)|negative regulation of transcription from RNA polymerase II promoter (GO:0000122)|positive regulation of cell cycle (GO:0045787)|positive regulation of gene expression (GO:0010628)|protein stabilization (GO:0050821)|regulation of protein complex assembly (GO:0043254)|regulation of transcription, DNA-templated (GO:0006355)|release from viral latency (GO:0019046)|transcription from RNA polymerase II promoter (GO:0006366)	cytoplasm (GO:0005737)|histone acetyltransferase complex (GO:0000123)|membrane (GO:0016020)|mitochondrion (GO:0005739)|MLL1 complex (GO:0071339)|MLL5-L complex (GO:0070688)|neuronal cell body (GO:0043025)|nucleoplasm (GO:0005654)|nucleus (GO:0005634)|Set1C/COMPASS complex (GO:0048188)	chromatin binding (GO:0003682)|identical protein binding (GO:0042802)|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001205)|sequence-specific DNA binding transcription factor activity (GO:0003700)|transcription coactivator activity (GO:0003713)			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGAGGGGCCCGGGACCGGTGT	0.662																																						dbGAP											0													48.0	49.0	49.0					X																	153219074		2104	4206	6310	-	-	-	SO:0001583	missense	0				CCDS44020.1	Xq28	2014-06-12	2014-06-09		ENSG00000172534	ENSG00000172534			4839	protein-coding gene	gene with protein product	"""VP16-accessory protein"", ""protein phosphatase 1, regulatory subunit 89"""	300019	"""mental retardation, X-linked 3"", ""host cell factor C1 (VP16-accessory protein)"""	HFC1, MRX3		8392914, 23000143	Standard	XM_005274664		Approved	HCF-1, HCF1, CFF, VCAF, MGC70925, PPP1R89	uc004fjp.3	P51610	OTTHUMG00000024222	ENST00000310441.7:c.4481C>T	X.37:g.153219074G>A	ENSP00000309555:p.Pro1494Leu	Somatic		WXS	Illumina GAIIx	Phase_IV	Q6P4G5	Missense_Mutation	SNP	pfam_Kelch_2,pfam_Kelch_1,superfamily_Fibronectin_type3,smart_Fibronectin_type3	p.P1494L	ENST00000310441.7	37	c.4481	CCDS44020.1	X	.	.	.	.	.	.	.	.	.	.	G	22.0	4.232035	0.79688	.	.	ENSG00000172534	ENST00000310441;ENST00000369984;ENST00000354233	T;T;T	0.23552	3.19;1.9;3.19	5.94	5.94	0.96194	.	0.000000	0.85682	D	0.000000	T	0.37100	0.0991	L	0.43923	1.385	0.80722	D	1	D	0.76494	0.999	P	0.53006	0.715	T	0.06899	-1.0801	10	0.72032	D	0.01	.	17.9312	0.88998	0.0:0.0:1.0:0.0	.	1494	P51610	HCFC1_HUMAN	L	1494;1494;1425	ENSP00000309555:P1494L;ENSP00000359001:P1494L;ENSP00000346174:P1425L	ENSP00000309555:P1494L	P	-	2	0	HCFC1	152872268	1.000000	0.71417	0.402000	0.26371	0.211000	0.24417	8.795000	0.91872	2.509000	0.84616	0.529000	0.55759	CCG	HCFC1	-	NULL	ENSG00000172534		0.662	HCFC1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	HCFC1	HGNC	protein_coding	OTTHUMT00000061099.4	39	0.00	0	G	NM_005334		153219074	153219074	-1	no_errors	ENST00000310441	ensembl	human	known	69_37n	missense	31	27.91	12	SNP	0.996	A
HCN1	348980	genome.wustl.edu	37	5	45262056	45262056	+	Silent	SNP	G	G	A			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	G	G					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chr5:45262056G>A	ENST00000303230.4	-	8	2697	c.2640C>T	c.(2638-2640)gaC>gaT	p.D880D		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	880					apical protein localization (GO:0045176)|cellular response to cAMP (GO:0071320)|potassium ion transmembrane transport (GO:0071805)|potassium ion transport (GO:0006813)|regulation of membrane potential (GO:0042391)|retinal cone cell development (GO:0046549)|sodium ion transmembrane transport (GO:0035725)|synaptic transmission (GO:0007268)	axon (GO:0030424)|dendrite (GO:0030425)|integral component of membrane (GO:0016021)|integral component of plasma membrane (GO:0005887)|plasma membrane (GO:0005886)	cAMP binding (GO:0030552)|intracellular cAMP activated cation channel activity (GO:0005222)|potassium channel activity (GO:0005267)|voltage-gated potassium channel activity (GO:0005249)|voltage-gated sodium channel activity (GO:0005248)	p.D880D(1)		NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						GCTTTTCTGCGTCTGGGTCTG	0.478																																						dbGAP											1	Substitution - coding silent(1)	prostate(1)											92.0	107.0	102.0					5																	45262056		2203	4300	6503	-	-	-	SO:0001819	synonymous_variant	0			AF064876	CCDS3952.1	5p12	2011-07-05			ENSG00000164588	ENSG00000164588		"""Voltage-gated ion channels / Cyclic nucleotide-regulated channels"""	4845	protein-coding gene	gene with protein product		602780		BCNG1		9405696, 9630217, 16382102	Standard	NM_021072		Approved	BCNG-1, HAC-2	uc003jok.3	O60741	OTTHUMG00000131155	ENST00000303230.4:c.2640C>T	5.37:g.45262056G>A		Somatic		WXS	Illumina GAIIx	Phase_IV		Silent	SNP	pfam_Ion_trans_N,pfam_cNMP-bd_dom,pfam_Ion_trans_dom,superfamily_cNMP-bd-like,smart_cNMP-bd_dom,pfscan_cNMP-bd_dom,prints_K_chnl_volt-dep_EAG/ELK/ERG	p.D880	ENST00000303230.4	37	c.2640	CCDS3952.1	5																																																																																			HCN1	-	NULL	ENSG00000164588		0.478	HCN1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	HCN1	HGNC	protein_coding	OTTHUMT00000253847.1	120	0.00	0	G	NM_021072		45262056	45262056	-1	no_errors	ENST00000303230	ensembl	human	known	69_37n	silent	103	23.70	32	SNP	0.746	A
MAGEB16	139604	genome.wustl.edu	37	X	35820757	35820757	+	Silent	SNP	G	G	A			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	G	G					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chrX:35820757G>A	ENST00000399989.1	+	2	723	c.444G>A	c.(442-444)gaG>gaA	p.E148E	MAGEB16_ENST00000399992.1_Silent_p.E180E|MAGEB16_ENST00000399985.1_Silent_p.E148E|MAGEB16_ENST00000399987.1_Silent_p.E148E|MAGEB16_ENST00000399988.1_Silent_p.E148E	NM_001099921.1	NP_001093391.1	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	148	MAGE. {ECO:0000255|PROSITE- ProRule:PRU00127}.									breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						AAGATGATGAGAGCCACTTCT	0.448																																						dbGAP											0													78.0	76.0	77.0					X																	35820757		2029	4174	6203	-	-	-	SO:0001819	synonymous_variant	0				CCDS43927.1	Xp21.1	2010-05-26	2005-11-07		ENSG00000189023	ENSG00000189023			21188	protein-coding gene	gene with protein product		300762	"""melanoma antigen family B, 16 (pseudogene)"""			11454705	Standard	NM_001099921		Approved		uc010ngt.1	A2A368	OTTHUMG00000021348	ENST00000399989.1:c.444G>A	X.37:g.35820757G>A		Somatic		WXS	Illumina GAIIx	Phase_IV	A8MU30	Silent	SNP	pfam_MAGE,pfam_Melanoma_ass_antigen_N,pfscan_MAGE	p.E180	ENST00000399989.1	37	c.540	CCDS43927.1	X																																																																																			MAGEB16	-	pfam_MAGE,pfscan_MAGE	ENSG00000189023		0.448	MAGEB16-005	KNOWN	basic|appris_principal|CCDS	protein_coding	MAGEB16	HGNC	protein_coding	OTTHUMT00000251034.1	200	0.00	0	G			35820757	35820757	+1	no_errors	ENST00000399992	ensembl	human	known	69_37n	silent	105	32.26	50	SNP	0.000	A
MAGEE2	139599	genome.wustl.edu	37	X	75004102	75004102	+	Missense_Mutation	SNP	G	G	C	rs200633627		TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	G	G					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chrX:75004102G>C	ENST00000373359.2	-	1	977	c.785C>G	c.(784-786)aCa>aGa	p.T262R		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	262	MAGE 1. {ECO:0000255|PROSITE- ProRule:PRU00127}.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TTCCATCTTTGTGATTTCCCT	0.488																																						dbGAP											0													61.0	60.0	60.0					X																	75004102		2203	4300	6503	-	-	-	SO:0001583	missense	0			AF490509	CCDS14431.1	Xq13	2008-02-05			ENSG00000186675	ENSG00000186675			24935	protein-coding gene	gene with protein product		300760				11454705	Standard	NM_138703		Approved	HCA3	uc004ecj.2	Q8TD90	OTTHUMG00000021870	ENST00000373359.2:c.785C>G	X.37:g.75004102G>C	ENSP00000362457:p.Thr262Arg	Somatic		WXS	Illumina GAIIx	Phase_IV	Q5JSI5	Missense_Mutation	SNP	pfam_MAGE,pfscan_MAGE	p.T262R	ENST00000373359.2	37	c.785	CCDS14431.1	X	.	.	.	.	.	.	.	.	.	.	G	13.28	2.190827	0.38707	.	.	ENSG00000186675	ENST00000373359	T	0.05081	3.5	3.1	2.23	0.28157	.	.	.	.	.	T	0.18593	0.0446	M	0.71871	2.18	0.26777	N	0.969685	D	0.89917	1.0	D	0.72982	0.979	T	0.05162	-1.0902	9	0.66056	D	0.02	.	5.2674	0.15607	0.1633:0.0:0.8367:0.0	.	262	Q8TD90	MAGE2_HUMAN	R	262	ENSP00000362457:T262R	ENSP00000362457:T262R	T	-	2	0	MAGEE2	74920827	1.000000	0.71417	0.977000	0.42913	0.762000	0.43233	0.876000	0.28092	0.689000	0.31550	0.422000	0.28245	ACA	MAGEE2	-	pfam_MAGE,pfscan_MAGE	ENSG00000186675		0.488	MAGEE2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	MAGEE2	HGNC	protein_coding	OTTHUMT00000057288.1	115	0.00	0	G	NM_138703		75004102	75004102	-1	no_errors	ENST00000373359	ensembl	human	known	69_37n	missense	89	28.23	35	SNP	0.977	C
MPDZ	8777	genome.wustl.edu	37	9	13224396	13224396	+	Missense_Mutation	SNP	G	G	C			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	G	G					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chr9:13224396G>C	ENST00000319217.7	-	4	617	c.370C>G	c.(370-372)Cag>Gag	p.Q124E	MPDZ_ENST00000541718.1_Missense_Mutation_p.Q124E|MPDZ_ENST00000381022.2_Missense_Mutation_p.Q124E|MPDZ_ENST00000536827.1_Missense_Mutation_p.Q124E|MPDZ_ENST00000381015.4_Missense_Mutation_p.Q124E|MPDZ_ENST00000447879.1_Missense_Mutation_p.Q124E|MPDZ_ENST00000546205.1_Missense_Mutation_p.Q124E	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	124					cell adhesion (GO:0007155)|myelination (GO:0042552)|viral process (GO:0016032)	apical plasma membrane (GO:0016324)|apicolateral plasma membrane (GO:0016327)|cytoplasm (GO:0005737)|cytoplasmic vesicle (GO:0031410)|neuron projection (GO:0043005)|postsynaptic membrane (GO:0045211)|Schmidt-Lanterman incisure (GO:0043220)|tight junction (GO:0005923)	protein C-terminus binding (GO:0008022)			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		TTGATAAGCTGATCAAATTCA	0.343																																						dbGAP											0													120.0	115.0	116.0					9																	13224396		1834	4083	5917	-	-	-	SO:0001583	missense	0			AF093419	CCDS47951.1, CCDS59119.1, CCDS59120.1	9p23	2008-05-15			ENSG00000107186	ENSG00000107186			7208	protein-coding gene	gene with protein product		603785					Standard	NM_003829		Approved	MUPP1	uc003zlb.4	O75970	OTTHUMG00000021031	ENST00000319217.7:c.370C>G	9.37:g.13224396G>C	ENSP00000320006:p.Gln124Glu	Somatic		WXS	Illumina GAIIx	Phase_IV	A6NLC2|B2RTS3|B7ZMI4|O43798|Q4LE30|Q5CZ80|Q5JTX3|Q5JTX6|Q5JTX7|Q5JUC3|Q5JUC4|Q5VZ62|Q8N790	Missense_Mutation	SNP	pfam_PDZ,pfam_L27_2,superfamily_PDZ,smart_PDZ,pfscan_L27,pfscan_PDZ	p.Q124E	ENST00000319217.7	37	c.370		9	.	.	.	.	.	.	.	.	.	.	G	15.71	2.915103	0.52546	.	.	ENSG00000107186	ENST00000319217;ENST00000541718;ENST00000381022;ENST00000536827;ENST00000447879;ENST00000381015;ENST00000399902;ENST00000546205	T;T;T;T;T;T;T	0.10192	2.95;2.9;2.9;2.9;2.94;2.95;2.95	5.72	5.72	0.89469	.	0.000000	0.42682	D	0.000673	T	0.07458	0.0188	L	0.29908	0.895	0.80722	D	1	B;B;B	0.30741	0.293;0.141;0.141	B;B;B	0.23018	0.027;0.043;0.043	T	0.17319	-1.0373	10	0.07482	T	0.82	.	14.0925	0.65000	0.0717:0.0:0.9283:0.0	.	124;124;124	B7ZMI4;O75970-3;O75970-2	.;.;.	E	124	ENSP00000320006:Q124E;ENSP00000439807:Q124E;ENSP00000370410:Q124E;ENSP00000444151:Q124E;ENSP00000415208:Q124E;ENSP00000370403:Q124E;ENSP00000446358:Q124E	ENSP00000320006:Q124E	Q	-	1	0	MPDZ	13214396	1.000000	0.71417	1.000000	0.80357	0.998000	0.95712	4.246000	0.58740	2.689000	0.91719	0.655000	0.94253	CAG	MPDZ	-	superfamily_PDZ	ENSG00000107186		0.343	MPDZ-001	KNOWN	not_organism_supported|basic	protein_coding	MPDZ	HGNC	protein_coding	OTTHUMT00000055485.2	312	0.00	0	G	NM_003829		13224396	13224396	-1	no_errors	ENST00000319217	ensembl	human	known	69_37n	missense	245	29.39	102	SNP	1.000	C
OR2A1	346528	genome.wustl.edu	37	7	144015463	144015463	+	Silent	SNP	G	G	A			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	G	G					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chr7:144015463G>A	ENST00000408951.1	+	1	246	c.246G>A	c.(244-246)gcG>gcA	p.A82A	OR2A1-AS1_ENST00000486094.1_RNA|OR2A1-AS1_ENST00000496968.1_RNA|OR2A1-AS1_ENST00000487102.1_RNA|OR2A1-AS1_ENST00000476560.1_RNA|OR2A1-AS1_ENST00000493539.1_RNA|OR2A1-AS1_ENST00000467944.1_RNA|OR2A1-AS1_ENST00000489488.1_RNA|OR2A1-AS1_ENST00000478925.1_RNA|OR2A1-AS1_ENST00000488041.1_RNA|OR2A1-AS1_ENST00000475089.1_RNA|OR2A1-AS1_ENST00000463561.1_RNA|OR2A1-AS1_ENST00000461843.1_RNA|OR2A1-AS1_ENST00000478806.1_RNA	NM_001005287.1	NP_001005287.1	Q8NGT9	OR2A1_HUMAN	olfactory receptor, family 2, subfamily A, member 1	82						integral component of membrane (GO:0016021)|plasma membrane (GO:0005886)	G-protein coupled receptor activity (GO:0004930)|olfactory receptor activity (GO:0004984)			large_intestine(1)|lung(3)|skin(2)	6	Melanoma(164;0.14)					AGATGCTGGCGAACCTCCTGC	0.577																																						dbGAP											0													76.0	91.0	86.0					7																	144015463		2202	4295	6497	-	-	-	SO:0001819	synonymous_variant	0				CCDS43673.1	7q35	2013-09-20			ENSG00000221970	ENSG00000221970		"""GPCR / Class A : Olfactory receptors"""	8229	protein-coding gene	gene with protein product							Standard	NM_001005287		Approved		uc011kub.2	Q8NGT9	OTTHUMG00000158005	ENST00000408951.1:c.246G>A	7.37:g.144015463G>A		Somatic		WXS	Illumina GAIIx	Phase_IV	Q6IF44|Q96R46	Silent	SNP	pfam_7TM_GPCR_Rhodpsn,prints_Olfact_rcpt,prints_7TM_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_supfam	p.A82	ENST00000408951.1	37	c.246	CCDS43673.1	7																																																																																			OR2A1	-	pfam_7TM_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_supfam	ENSG00000221970		0.577	OR2A1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	OR2A1	HGNC	protein_coding	OTTHUMT00000349985.1	96	0.00	0	G			144015463	144015463	+1	no_errors	ENST00000408951	ensembl	human	known	69_37n	silent	112	20.00	28	SNP	0.002	A
POU2F3	25833	genome.wustl.edu	37	11	120180259	120180259	+	Silent	SNP	C	C	T			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	C	C					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chr11:120180259C>T	ENST00000543440.2	+	10	1182	c.1032C>T	c.(1030-1032)gcC>gcT	p.A344A	POU2F3_ENST00000260264.4_Silent_p.A346A	NM_014352.3	NP_055167.2	Q9UKI9	PO2F3_HUMAN	POU class 2 homeobox 3	344					epidermis development (GO:0008544)|keratinocyte differentiation (GO:0030216)|negative regulation by host of viral transcription (GO:0043922)|positive regulation of transcription from RNA polymerase II promoter (GO:0045944)|regulation of transcription from RNA polymerase II promoter (GO:0006357)|wound healing (GO:0042060)	cytoplasm (GO:0005737)|nucleus (GO:0005634)|transcription factor complex (GO:0005667)	RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077)|sequence-specific DNA binding (GO:0043565)			large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)	17		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		GCCCTGTGGCCACACCCATCA	0.567																																						dbGAP											0													100.0	74.0	83.0					11																	120180259		2203	4299	6502	-	-	-	SO:0001819	synonymous_variant	0			AF133895	CCDS8431.1, CCDS58190.1	11q23.3	2011-06-20	2007-07-13		ENSG00000137709	ENSG00000137709		"""Homeoboxes / POU class"""	19864	protein-coding gene	gene with protein product		607394	"""POU domain class 2, transcription factor 3"""			10473598	Standard	NM_014352		Approved	OCT11, PLA-1, Skn-1a, Epoc-1	uc021qrk.1	Q9UKI9	OTTHUMG00000166140	ENST00000543440.2:c.1032C>T	11.37:g.120180259C>T		Somatic		WXS	Illumina GAIIx	Phase_IV	A8K7H8|B4DY07|F5GWW6|Q3MIY3|Q9UKR7|Q9Y504	Silent	SNP	pfam_POU_specific,pfam_Homeodomain,superfamily_Lambda_DNA-bd_dom,superfamily_Homeodomain-like,smart_POU_specific,smart_Homeodomain,pfscan_Homeodomain,pfscan_POU_specific,prints_POU,prints_TF_octamer	p.A346	ENST00000543440.2	37	c.1038	CCDS8431.1	11																																																																																			POU2F3	-	NULL	ENSG00000137709		0.567	POU2F3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	POU2F3	HGNC	protein_coding	OTTHUMT00000388039.2	138	0.00	0	C			120180259	120180259	+1	no_errors	ENST00000543440	ensembl	human	known	69_37n	silent	90	31.82	42	SNP	0.731	T
PPAN	56342	genome.wustl.edu	37	19	10221623	10221623	+	Missense_Mutation	SNP	C	C	G			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	C	C					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chr19:10221623C>G	ENST00000253107.7	+	12	1310	c.1204C>G	c.(1204-1206)Ctg>Gtg	p.L402V	P2RY11_ENST00000321826.4_5'Flank|PPAN_ENST00000556468.1_Missense_Mutation_p.L402V|SNORD105B_ENST00000458770.1_RNA|PPAN-P2RY11_ENST00000393796.4_Missense_Mutation_p.L402V|PPAN_ENST00000393793.1_Missense_Mutation_p.L349V|PPAN-P2RY11_ENST00000428358.1_Missense_Mutation_p.L402V	NM_020230.5	NP_064615.3	Q9NQ55	SSF1_HUMAN	peter pan homolog (Drosophila)	402					RNA splicing (GO:0008380)	nucleus (GO:0005634)	poly(A) RNA binding (GO:0044822)			endometrium(3)|liver(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	15			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			CCCCACAGACCTGTTCCCCGA	0.642																																						dbGAP											0													50.0	55.0	53.0					19																	10221623		2203	4300	6503	-	-	-	SO:0001583	missense	0			BC033202	CCDS12225.1	19p13.2	2008-02-05	2001-11-28		ENSG00000130810	ENSG00000130810			9227	protein-coding gene	gene with protein product		607793	"""peter pan (Drosophila) homolog"""			10873382	Standard	NM_020230		Approved	SSF1, SSF2, SSF, BXDC3		Q9NQ55	OTTHUMG00000156826	ENST00000253107.7:c.1204C>G	19.37:g.10221623C>G	ENSP00000253107:p.Leu402Val	Somatic		WXS	Illumina GAIIx	Phase_IV	C9J3F9|Q9BW97|Q9H170	Missense_Mutation	SNP	pfam_Brix,pfam_7TM_GPCR_Rhodpsn,superfamily_Anticodon-bd,smart_Brix,prints_P2_purnocptor,prints_7TM_GPCR_Rhodpsn,pfscan_Brix,pfscan_GPCR_Rhodpsn_supfam	p.L402V	ENST00000253107.7	37	c.1204	CCDS12225.1	19	.	.	.	.	.	.	.	.	.	.	C	10.43	1.348982	0.24426	.	.	ENSG00000243207;ENSG00000243207;ENSG00000130810;ENSG00000130810;ENSG00000130810;ENSG00000130810	ENST00000428358;ENST00000393796;ENST00000253107;ENST00000556468;ENST00000342696;ENST00000393793	T;T;T;T;T	0.63255	1.34;-0.03;1.45;-0.03;1.46	4.9	-1.79	0.07932	.	.	.	.	.	T	0.49133	0.1539	M	0.62723	1.935	0.45852	D	0.998711	P;P;P	0.37441	0.595;0.595;0.595	B;B;B	0.31869	0.137;0.097;0.137	T	0.40794	-0.9544	9	0.59425	D	0.04	-26.6377	5.0297	0.14404	0.2713:0.2989:0.0:0.4298	.	402;402;402	C9J3F9;C9JW41;Q9NQ55	.;.;SSF1_HUMAN	V	402;402;402;402;402;349	ENSP00000411918:L402V;ENSP00000377385:L402V;ENSP00000253107:L402V;ENSP00000450710:L402V;ENSP00000377382:L349V	ENSP00000253107:L402V	L	+	1	2	PPAN;PPAN-P2RY11	10082623	0.985000	0.35326	0.965000	0.40720	0.109000	0.19521	1.453000	0.35167	-0.376000	0.07943	-0.397000	0.06425	CTG	PPAN-P2RY11	-	NULL	ENSG00000243207		0.642	PPAN-001	KNOWN	basic|appris_principal|CCDS	protein_coding	PPAN-P2RY11	HGNC	protein_coding	OTTHUMT00000316658.1	41	0.00	0	C	NM_020230		10221623	10221623	+1	no_errors	ENST00000393796	ensembl	human	known	69_37n	missense	31	38.00	19	SNP	0.996	G
PRCP	5547	genome.wustl.edu	37	11	82561013	82561013	+	Missense_Mutation	SNP	G	G	A			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	G	G					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chr11:82561013G>A	ENST00000313010.3	-	5	888	c.694C>T	c.(694-696)Cat>Tat	p.H232Y	PRCP_ENST00000393399.2_Missense_Mutation_p.H253Y|PRCP_ENST00000535099.1_Missense_Mutation_p.H127Y	NM_005040.2	NP_005031.1	P42785	PCP_HUMAN	prolylcarboxypeptidase (angiotensinase C)	232	SKS domain.				angiogenesis involved in wound healing (GO:0060055)|blood coagulation (GO:0007596)|blood coagulation, intrinsic pathway (GO:0007597)|energy homeostasis (GO:0097009)|glucose homeostasis (GO:0042593)|negative regulation of systemic arterial blood pressure (GO:0003085)|plasma kallikrein-kinin cascade (GO:0002353)|regulation of blood vessel endothelial cell migration (GO:0043535)|regulation of reactive oxygen species metabolic process (GO:2000377)|regulation of thyroid hormone mediated signaling pathway (GO:0002155)	basal part of cell (GO:0045178)|extracellular vesicular exosome (GO:0070062)|lysosome (GO:0005764)|plasma membrane (GO:0005886)	serine-type carboxypeptidase activity (GO:0004185)			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	17						TCTGAACAATGTGGACCGCTT	0.408																																						dbGAP											0													77.0	78.0	78.0					11																	82561013		2203	4300	6503	-	-	-	SO:0001583	missense	0			BC001500, BI827978, L13977	CCDS8262.1, CCDS41695.1	11q14	2005-10-04				ENSG00000137509			9344	protein-coding gene	gene with protein product		176785				8344943	Standard	NM_199418		Approved	PCP, HUMPCP	uc001ozr.3	P42785		ENST00000313010.3:c.694C>T	11.37:g.82561013G>A	ENSP00000317362:p.His232Tyr	Somatic		WXS	Illumina GAIIx	Phase_IV	A8MU24|B2R7B7|B3KRK5|B5BU34	Missense_Mutation	SNP	pfam_Peptidase_S28	p.H253Y	ENST00000313010.3	37	c.757	CCDS8262.1	11	.	.	.	.	.	.	.	.	.	.	G	12.50	1.956229	0.34565	.	.	ENSG00000137509	ENST00000313010;ENST00000393399;ENST00000535099;ENST00000531801;ENST00000534631;ENST00000527444;ENST00000531128;ENST00000534396	D;D;D;D;D;D;T;T	0.92048	-2.96;-2.96;-2.96;-2.96;-2.96;-2.96;2.57;2.57	5.34	-5.94	0.02247	.	0.681448	0.16192	N	0.225337	T	0.71459	0.3342	N	0.04636	-0.2	0.09310	N	1	B;B	0.06786	0.001;0.0	B;B	0.06405	0.001;0.002	T	0.66180	-0.5988	9	.	.	.	-0.7638	1.2812	0.02041	0.4306:0.2125:0.2164:0.1405	.	232;253	P42785;A8MU24	PCP_HUMAN;.	Y	232;253;127;127;127;127;127;127	ENSP00000317362:H232Y;ENSP00000377055:H253Y;ENSP00000442077:H127Y;ENSP00000432004:H127Y;ENSP00000431559:H127Y;ENSP00000436141:H127Y;ENSP00000431435:H127Y;ENSP00000432506:H127Y	.	H	-	1	0	PRCP	82238661	0.000000	0.05858	0.907000	0.35723	0.885000	0.51271	-0.375000	0.07475	-0.987000	0.03494	-2.132000	0.00343	CAT	PRCP	-	pfam_Peptidase_S28	ENSG00000137509		0.408	PRCP-001	KNOWN	basic|appris_principal|CCDS	protein_coding	PRCP	HGNC	protein_coding	OTTHUMT00000391792.1	126	0.00	0	G	NM_005040		82561013	82561013	-1	no_errors	ENST00000393399	ensembl	human	known	69_37n	missense	111	25.50	38	SNP	0.001	A
RUNX1	861	genome.wustl.edu	37	21	36252880	36252880	+	Missense_Mutation	SNP	A	A	G			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	A	A					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chr21:36252880A>G	ENST00000344691.4	-	2	1978	c.401T>C	c.(400-402)cTc>cCc	p.L134P	RUNX1_ENST00000486278.2_Missense_Mutation_p.L137P|RUNX1_ENST00000300305.3_Missense_Mutation_p.L161P|RUNX1_ENST00000358356.5_Missense_Mutation_p.L134P|RUNX1_ENST00000437180.1_Missense_Mutation_p.L161P|RUNX1_ENST00000325074.5_Missense_Mutation_p.L149P|RUNX1_ENST00000399240.1_Missense_Mutation_p.L134P	NM_001001890.2	NP_001001890.1	Q01196	RUNX1_HUMAN	runt-related transcription factor 1	134	Runt. {ECO:0000255|PROSITE- ProRule:PRU00399}.				behavioral response to pain (GO:0048266)|cellular response to transforming growth factor beta stimulus (GO:0071560)|central nervous system development (GO:0007417)|definitive hemopoiesis (GO:0060216)|embryonic hemopoiesis (GO:0035162)|hair follicle morphogenesis (GO:0031069)|hematopoietic stem cell proliferation (GO:0071425)|hemopoiesis (GO:0030097)|in utero embryonic development (GO:0001701)|liver development (GO:0001889)|myeloid cell differentiation (GO:0030099)|myeloid progenitor cell differentiation (GO:0002318)|negative regulation of granulocyte differentiation (GO:0030853)|peripheral nervous system neuron development (GO:0048935)|positive regulation of angiogenesis (GO:0045766)|positive regulation of granulocyte differentiation (GO:0030854)|positive regulation of progesterone secretion (GO:2000872)|positive regulation of transcription from RNA polymerase II promoter (GO:0045944)|positive regulation of transcription, DNA-templated (GO:0045893)|regulation of hair follicle cell proliferation (GO:0071336)|regulation of signal transduction (GO:0009966)|skeletal system development (GO:0001501)|transcription, DNA-templated (GO:0006351)	basement membrane (GO:0005604)|nucleus (GO:0005634)	ATP binding (GO:0005524)|calcium ion binding (GO:0005509)|DNA binding (GO:0003677)|protein heterodimerization activity (GO:0046982)|protein homodimerization activity (GO:0042803)|regulatory region DNA binding (GO:0000975)|sequence-specific DNA binding transcription factor activity (GO:0003700)|transcription factor binding (GO:0008134)	p.N159fs*49(1)		breast(5)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(428)|large_intestine(3)|lung(6)|oesophagus(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	452						GACAAACCTGAGGTCATTAAA	0.438			T	"""RPL22, MDS1, EVI1, CBFA2T3, CBFA2T1, ETV6, LAF4"""	"""AML, preB- ALL, T-ALL"""																																	dbGAP		Dom	yes		21	21q22.3	861	runt-related transcription factor 1  (AML1)		L	1	Deletion - Frameshift(1)	haematopoietic_and_lymphoid_tissue(1)											119.0	105.0	110.0					21																	36252880		2203	4300	6503	-	-	-	SO:0001583	missense	0			X79549	CCDS13639.1, CCDS42922.1, CCDS46646.1	21q22.3	2014-09-17	2008-07-29		ENSG00000159216	ENSG00000159216			10471	protein-coding gene	gene with protein product	"""aml1 oncogene"""	151385	"""acute myeloid leukemia 1"""	AML1, CBFA2		1427868, 7835892	Standard	NM_001001890		Approved	PEBP2A2, AMLCR1	uc010gmv.3	Q01196	OTTHUMG00000086299	ENST00000344691.4:c.401T>C	21.37:g.36252880A>G	ENSP00000340690:p.Leu134Pro	Somatic		WXS	Illumina GAIIx	Phase_IV	A8MV94|B2RMS4|D3DSG1|O60472|O60473|O76047|O76089|Q13081|Q13755|Q13756|Q13757|Q13758|Q13759|Q15341|Q15343|Q16122|Q16284|Q16285|Q16286|Q16346|Q16347|Q92479	Missense_Mutation	SNP	pfam_AML1/Runt_N,pfam_RunxI,superfamily_p53-like_TF_DNA-bd,pirsf_TF_Runt-rel_RUNX,pfscan_AML1/Runt_N,prints_AML1_Runt	p.L161P	ENST00000344691.4	37	c.482	CCDS42922.1	21	.	.	.	.	.	.	.	.	.	.	A	25.2	4.613395	0.87359	.	.	ENSG00000159216	ENST00000344691;ENST00000300305;ENST00000437180;ENST00000325074;ENST00000399240;ENST00000399245;ENST00000358356;ENST00000399237;ENST00000486278	D;D;D;D;D;D;D;D	0.99804	-6.83;-6.83;-6.83;-6.83;-6.83;-6.83;-6.83;-6.83	5.31	5.31	0.75309	Acute myeloid leukemia 1 (AML 1)/Runt (2);p53-like transcription factor, DNA-binding (1);p53/RUNT-type transcription factor, DNA-binding domain (1);	0.000000	0.85682	D	0.000000	D	0.99809	0.9917	M	0.91300	3.195	0.80722	D	1	D;D;D;D;D;D;D	0.89917	1.0;1.0;1.0;1.0;1.0;1.0;1.0	D;D;D;D;D;D;D	0.97110	1.0;1.0;1.0;1.0;1.0;1.0;1.0	D	0.96830	0.9610	10	0.87932	D	0	-34.4716	15.5565	0.76200	1.0:0.0:0.0:0.0	.	161;134;134;137;161;149;134	Q2TAM6;Q01196-5;Q01196-3;C9JK12;Q01196-8;Q01196-10;Q01196	.;.;.;.;.;.;RUNX1_HUMAN	P	134;161;161;149;134;137;134;149;137	ENSP00000340690:L134P;ENSP00000300305:L161P;ENSP00000409227:L161P;ENSP00000319459:L149P;ENSP00000382184:L134P;ENSP00000351123:L134P;ENSP00000382182:L149P;ENSP00000438019:L137P	ENSP00000300305:L161P	L	-	2	0	RUNX1	35174750	1.000000	0.71417	1.000000	0.80357	0.993000	0.82548	8.910000	0.92685	2.143000	0.66587	0.533000	0.62120	CTC	RUNX1	-	pfam_AML1/Runt_N,superfamily_p53-like_TF_DNA-bd,pirsf_TF_Runt-rel_RUNX,pfscan_AML1/Runt_N,prints_AML1_Runt	ENSG00000159216		0.438	RUNX1-001	KNOWN	basic|CCDS	protein_coding	RUNX1	HGNC	protein_coding	OTTHUMT00000194230.1	273	0.00	0	A			36252880	36252880	-1	no_errors	ENST00000300305	ensembl	human	known	69_37n	missense	202	26.55	73	SNP	1.000	G
TP53	7157	genome.wustl.edu	37	17	7579359	7579359	+	Frame_Shift_Del	DEL	G	G	-	rs587781371|rs587780066		TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	G	G					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chr17:7579359delG	ENST00000269305.4	-	4	517	c.328delC	c.(328-330)cgtfs	p.R110fs	TP53_ENST00000420246.2_Frame_Shift_Del_p.R110fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.R110fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.R110fs|TP53_ENST00000413465.2_Frame_Shift_Del_p.R110fs|TP53_ENST00000574684.1_5'Flank|TP53_ENST00000455263.2_Frame_Shift_Del_p.R110fs	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	110	Interaction with HIPK1. {ECO:0000250}.|Interaction with WWOX.|Required for interaction with ZNF385A.		R -> C (in sporadic cancers; somatic mutation).|R -> G (in a sporadic cancer; somatic mutation).|R -> H (in sporadic cancers; somatic mutation).|R -> L (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation; does not induce SNAI1 degradation).|R -> P (in sporadic cancers; somatic mutation; dbSNP:rs11540654). {ECO:0000269|PubMed:17224074}.|R -> S (in a sporadic cancer; somatic mutation).		apoptotic process (GO:0006915)|B cell lineage commitment (GO:0002326)|base-excision repair (GO:0006284)|blood coagulation (GO:0007596)|cell aging (GO:0007569)|cell cycle arrest (GO:0007050)|cell differentiation (GO:0030154)|cell proliferation (GO:0008283)|cellular protein localization (GO:0034613)|cellular response to DNA damage stimulus (GO:0006974)|cellular response to drug (GO:0035690)|cellular response to glucose starvation (GO:0042149)|cellular response to hypoxia (GO:0071456)|cellular response to ionizing radiation (GO:0071479)|cellular response to UV (GO:0034644)|cerebellum development (GO:0021549)|chromatin assembly (GO:0031497)|determination of adult lifespan (GO:0008340)|DNA damage response, signal transduction by p53 class mediator (GO:0030330)|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:0006977)|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (GO:0006978)|DNA strand renaturation (GO:0000733)|double-strand break repair (GO:0006302)|embryonic organ development (GO:0048568)|ER overload response (GO:0006983)|gastrulation (GO:0007369)|in utero embryonic development (GO:0001701)|intrinsic apoptotic signaling pathway (GO:0097193)|intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332)|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)|mitotic cell cycle arrest (GO:0071850)|mitotic G1 DNA damage checkpoint (GO:0031571)|multicellular organism growth (GO:0035264)|multicellular organismal development (GO:0007275)|necroptotic process (GO:0070266)|negative regulation of apoptotic process (GO:0043066)|negative regulation of cell growth (GO:0030308)|negative regulation of cell proliferation (GO:0008285)|negative regulation of DNA replication (GO:0008156)|negative regulation of fibroblast proliferation (GO:0048147)|negative regulation of helicase activity (GO:0051097)|negative regulation of macromitophagy (GO:1901525)|negative regulation of neuroblast proliferation (GO:0007406)|negative regulation of reactive oxygen species metabolic process (GO:2000378)|negative regulation of transcription from RNA polymerase II promoter (GO:0000122)|negative regulation of transcription, DNA-templated (GO:0045892)|negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)|neuron apoptotic process (GO:0051402)|Notch signaling pathway (GO:0007219)|nucleotide-excision repair (GO:0006289)|oligodendrocyte apoptotic process (GO:0097252)|oxidative stress-induced premature senescence (GO:0090403)|positive regulation of apoptotic process (GO:0043065)|positive regulation of cardiac muscle cell apoptotic process (GO:0010666)|positive regulation of cell aging (GO:0090343)|positive regulation of cell cycle arrest (GO:0071158)|positive regulation of histone deacetylation (GO:0031065)|positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)|positive regulation of mitochondrial membrane permeability (GO:0035794)|positive regulation of neuron apoptotic process (GO:0043525)|positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (GO:1900740)|positive regulation of protein oligomerization (GO:0032461)|positive regulation of reactive oxygen species metabolic process (GO:2000379)|positive regulation of release of cytochrome c from mitochondria (GO:0090200)|positive regulation of thymocyte apoptotic process (GO:0070245)|positive regulation of transcription from RNA polymerase II promoter (GO:0045944)|positive regulation of transcription, DNA-templated (GO:0045893)|protein complex assembly (GO:0006461)|protein import into nucleus, translocation (GO:0000060)|protein localization (GO:0008104)|protein tetramerization (GO:0051262)|Ras protein signal transduction (GO:0007265)|regulation of apoptotic process (GO:0042981)|regulation of mitochondrial membrane permeability (GO:0046902)|regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)|regulation of tissue remodeling (GO:0034103)|regulation of transcription, DNA-templated (GO:0006355)|release of cytochrome c from mitochondria (GO:0001836)|replicative senescence (GO:0090399)|response to antibiotic (GO:0046677)|response to gamma radiation (GO:0010332)|response to ischemia (GO:0002931)|response to salt stress (GO:0009651)|response to X-ray (GO:0010165)|rRNA transcription (GO:0009303)|somitogenesis (GO:0001756)|T cell differentiation in thymus (GO:0033077)|T cell lineage commitment (GO:0002360)|T cell proliferation involved in immune response (GO:0002309)|transforming growth factor beta receptor signaling pathway (GO:0007179)|viral process (GO:0016032)	chromatin (GO:0000785)|cytoplasm (GO:0005737)|cytosol (GO:0005829)|endoplasmic reticulum (GO:0005783)|mitochondrial matrix (GO:0005759)|mitochondrion (GO:0005739)|nuclear chromatin (GO:0000790)|nuclear matrix (GO:0016363)|nucleolus (GO:0005730)|nucleoplasm (GO:0005654)|nucleus (GO:0005634)|PML body (GO:0016605)|protein complex (GO:0043234)|replication fork (GO:0005657)	ATP binding (GO:0005524)|chaperone binding (GO:0051087)|chromatin binding (GO:0003682)|copper ion binding (GO:0005507)|damaged DNA binding (GO:0003684)|DNA binding (GO:0003677)|enzyme binding (GO:0019899)|histone acetyltransferase binding (GO:0035035)|histone deacetylase regulator activity (GO:0035033)|identical protein binding (GO:0042802)|p53 binding (GO:0002039)|protease binding (GO:0002020)|protein heterodimerization activity (GO:0046982)|protein kinase binding (GO:0019901)|protein N-terminus binding (GO:0047485)|protein phosphatase 2A binding (GO:0051721)|protein phosphatase binding (GO:0019903)|receptor tyrosine kinase binding (GO:0030971)|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077)|RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979)|RNA polymerase II transcription factor binding (GO:0001085)|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228)|sequence-specific DNA binding transcription factor activity (GO:0003700)|transcription factor binding (GO:0008134)|transcription regulatory region DNA binding (GO:0044212)|ubiquitin protein ligase binding (GO:0031625)|zinc ion binding (GO:0008270)	p.R110fs*13(9)|p.0?(8)|p.R110C(7)|p.G59fs*23(3)|p.F109_R110delFR(2)|p.V73fs*9(1)|p.F109_R110insXX(1)|p.G105_T125del21(1)|p.R110fs*18(1)|p.Y107fs*44(1)|p.R110fs*39(1)|p.Y103_G112>C(1)|p.R110S(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y107fs*38(1)|p.Y103_L111>L(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)	Acetylsalicylic acid(DB00945)	AAGCCCAGACGGAAACCGTAG	0.607		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)																											Pancreas(47;798 1329 9957 10801)	dbGAP	yes	Rec	yes	Li-Fraumeni syndrome	17	17p13	7157	tumor protein p53		"""L, E, M, O"""	41	Deletion - Frameshift(17)|Whole gene deletion(8)|Substitution - Missense(8)|Deletion - In frame(3)|Insertion - Frameshift(2)|Complex - deletion inframe(2)|Insertion - In frame(1)	breast(11)|upper_aerodigestive_tract(4)|bone(4)|large_intestine(3)|lung(3)|NS(3)|prostate(3)|central_nervous_system(2)|liver(2)|skin(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|salivary_gland(1)|oesophagus(1)											62.0	59.0	60.0					17																	7579359		2203	4300	6503	-	-	-	SO:0001589	frameshift_variant	0	Familial Cancer Database	Familial Osteogenic Sarcoma;LFS, SBLA syndrome (Sarcoma Breast Leukemia Adrenal cancer), incl.: Cancer with In Vitro Radioresistence, Familial, Li-Fraumeni-like s.;BRCAX;Familial Adrenocortical Carcinoma;	AF307851	CCDS11118.1, CCDS45605.1, CCDS45606.1, CCDS73963.1, CCDS73964.1, CCDS73965.1, CCDS73966.1, CCDS73967.1, CCDS73968.1, CCDS73969.1, CCDS73970.1, CCDS73971.1	17p13.1	2014-09-17	2008-01-16		ENSG00000141510	ENSG00000141510			11998	protein-coding gene	gene with protein product	"""Li-Fraumeni syndrome"""	191170				6396087, 3456488, 2047879	Standard	NM_001126115		Approved	p53, LFS1	uc002gij.3	P04637	OTTHUMG00000162125	ENST00000269305.4:c.328delC	17.37:g.7579359delG	ENSP00000269305:p.Arg110fs	Somatic		WXS	Illumina GAIIx	Phase_IV	Q15086|Q15087|Q15088|Q16535|Q16807|Q16808|Q16809|Q16810|Q16811|Q16848|Q2XN98|Q3LRW1|Q3LRW2|Q3LRW3|Q3LRW4|Q3LRW5|Q86UG1|Q8J016|Q99659|Q9BTM4|Q9HAQ8|Q9NP68|Q9NPJ2|Q9NZD0|Q9UBI2|Q9UQ61	Frame_Shift_Del	DEL	pfam_p53_DNA-bd,pfam_p53_tetrameristn,pfam_p53_transactivation_domain,superfamily_p53-like_TF_DNA-bd,superfamily_p53_tetrameristn,prints_p53_tumour_suppressor	p.R110fs	ENST00000269305.4	37	c.328	CCDS11118.1	17																																																																																			TP53	-	pfam_p53_DNA-bd,superfamily_p53-like_TF_DNA-bd	ENSG00000141510		0.607	TP53-001	KNOWN	basic|appris_principal|CCDS	protein_coding	TP53	HGNC	protein_coding	OTTHUMT00000367397.1	58	0.00	0	G	NM_000546		7579359	7579359	-1	no_errors	ENST00000269305	ensembl	human	known	69_37n	frame_shift_del	24	27.27	9	DEL	0.028	-
TSR2	90121	genome.wustl.edu	37	X	54470525	54470525	+	Missense_Mutation	SNP	C	C	G			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	C	C					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chrX:54470525C>G	ENST00000375151.4	+	4	370	c.349C>G	c.(349-351)Cag>Gag	p.Q117E		NM_058163.1	NP_477511.1	Q969E8	TSR2_HUMAN	TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)	117					rRNA processing (GO:0006364)					breast(1)|endometrium(3)|lung(2)	6						CTGCATCACTCAGAGAAAATG	0.507																																						dbGAP											0													117.0	94.0	102.0					X																	54470525		2203	4300	6503	-	-	-	SO:0001583	missense	0			BC007699	CCDS14358.1	Xp11.22	2008-10-01			ENSG00000158526	ENSG00000158526			25455	protein-coding gene	gene with protein product	"""WGG motif containing 1"""					9417904	Standard	NM_058163		Approved	DT1P1A10, RP1-112K5.2, WGG1	uc004dte.3	Q969E8	OTTHUMG00000021628	ENST00000375151.4:c.349C>G	X.37:g.54470525C>G	ENSP00000364293:p.Gln117Glu	Somatic		WXS	Illumina GAIIx	Phase_IV		Missense_Mutation	SNP	pfam_Pre-rRNA_process_TSR2	p.Q117E	ENST00000375151.4	37	c.349	CCDS14358.1	X	.	.	.	.	.	.	.	.	.	.	c	17.33	3.363455	0.61513	.	.	ENSG00000158526	ENST00000375151	.	.	.	6.07	6.07	0.98685	.	0.182292	0.48767	D	0.000162	T	0.42131	0.1189	L	0.29908	0.895	0.52099	D	0.999948	P	0.47302	0.893	B	0.44315	0.446	T	0.35943	-0.9768	9	0.02654	T	1	-26.2879	16.3373	0.83068	0.0:1.0:0.0:0.0	.	117	Q969E8	TSR2_HUMAN	E	117	.	ENSP00000364293:Q117E	Q	+	1	0	TSR2	54487250	0.997000	0.39634	0.916000	0.36221	0.216000	0.24613	2.589000	0.46145	2.577000	0.86979	0.597000	0.82753	CAG	TSR2	-	NULL	ENSG00000158526		0.507	TSR2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	TSR2	HGNC	protein_coding	OTTHUMT00000056802.1	206	0.00	0	C	NM_058163		54470525	54470525	+1	no_errors	ENST00000375151	ensembl	human	known	69_37n	missense	143	25.52	49	SNP	0.993	G
UNC13A	23025	genome.wustl.edu	37	19	17760329	17760329	+	Missense_Mutation	SNP	C	C	T			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	C	C					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chr19:17760329C>T	ENST00000519716.2	-	13	1506	c.1507G>A	c.(1507-1509)Gtg>Atg	p.V503M	UNC13A_ENST00000552293.1_Missense_Mutation_p.V503M|UNC13A_ENST00000551649.1_Missense_Mutation_p.V503M|UNC13A_ENST00000252773.7_Missense_Mutation_p.V503M|UNC13A_ENST00000428389.2_Missense_Mutation_p.V591M|UNC13A_ENST00000550896.1_Missense_Mutation_p.V503M	NM_001080421.2	NP_001073890.2	Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	503					beta-amyloid metabolic process (GO:0050435)|innervation (GO:0060384)|intracellular signal transduction (GO:0035556)|neuromuscular junction development (GO:0007528)|neurotransmitter secretion (GO:0007269)|positive regulation of neurotransmitter secretion (GO:0001956)|regulation of short-term neuronal synaptic plasticity (GO:0048172)|regulation of synaptic transmission, glutamatergic (GO:0051966)|synaptic transmission, glutamatergic (GO:0035249)|synaptic vesicle docking involved in exocytosis (GO:0016081)|synaptic vesicle maturation (GO:0016188)	axon (GO:0030424)|cell junction (GO:0030054)|cytoplasm (GO:0005737)|neuromuscular junction (GO:0031594)|neuron projection (GO:0043005)|presynaptic active zone (GO:0048786)|presynaptic membrane (GO:0042734)	diacylglycerol binding (GO:0019992)|metal ion binding (GO:0046872)|protein N-terminus binding (GO:0047485)|syntaxin-1 binding (GO:0017075)			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						AAGTCGCTCACGAGTGGGATA	0.582																																						dbGAP											0													157.0	160.0	159.0					19																	17760329		2117	4234	6351	-	-	-	SO:0001583	missense	0			AB028955	CCDS46013.1, CCDS46013.2	19p13.12	2008-02-05				ENSG00000130477			23150	protein-coding gene	gene with protein product		609894					Standard	NM_001080421		Approved	KIAA1032, Munc13-1	uc031rjv.1	Q9UPW8		ENST00000519716.2:c.1507G>A	19.37:g.17760329C>T	ENSP00000429562:p.Val503Met	Somatic		WXS	Illumina GAIIx	Phase_IV	E5RHY9	Missense_Mutation	SNP	pfam_Munc13_subgr_dom-2,pfam_C2_Ca-dep,pfam_Ca-dep_secretion_activator,pfam_Prot_Kinase_C-like_PE/DAG-bd,superfamily_C2_Ca/lipid-bd_dom_CaLB,smart_C2_Ca-dep,smart_Prot_Kinase_C-like_PE/DAG-bd,pfscan_C2_membr_targeting,pfscan_Prot_Kinase_C-like_PE/DAG-bd,prints_C2_dom	p.V591M	ENST00000519716.2	37	c.1771	CCDS46013.2	19	.	.	.	.	.	.	.	.	.	.	C	21.3	4.125375	0.77436	.	.	ENSG00000130477	ENST00000519716;ENST00000428389;ENST00000252773;ENST00000551649;ENST00000552293;ENST00000550896	T;T;T;T;T;T	0.67171	-0.25;-0.25;-0.25;-0.25;-0.25;-0.25	4.25	4.25	0.50352	.	0.000000	0.64402	U	0.000002	T	0.79616	0.4476	M	0.72353	2.195	0.58432	D	0.999991	D	0.89917	1.0	D	0.75020	0.985	T	0.81750	-0.0790	10	0.56958	D	0.05	-21.357	14.4629	0.67465	0.0:1.0:0.0:0.0	.	503	Q9UPW8	UN13A_HUMAN	M	503;591;503;503;503;503	ENSP00000429562:V503M;ENSP00000400409:V591M;ENSP00000252773:V503M;ENSP00000447236:V503M;ENSP00000447572:V503M;ENSP00000446831:V503M	ENSP00000252773:V503M	V	-	1	0	UNC13A	17621329	1.000000	0.71417	0.998000	0.56505	0.709000	0.40893	7.565000	0.82337	2.067000	0.61834	0.561000	0.74099	GTG	UNC13A	-	NULL	ENSG00000130477		0.582	UNC13A-001	KNOWN	basic|appris_candidate|CCDS	protein_coding	UNC13A	HGNC	protein_coding	OTTHUMT00000376169.2	282	0.00	0	C	XM_038604		17760329	17760329	-1	no_errors	ENST00000428389	ensembl	human	known	69_37n	missense	209	25.36	71	SNP	1.000	T
WWP2	11060	genome.wustl.edu	37	16	69832690	69832690	+	Missense_Mutation	SNP	G	G	A			TCGA-AR-A1AN-01A-11D-A12Q-09	TCGA-AR-A1AN-10A-01D-A12Q-09	G	G					Unknown	Untested	Somatic	Phase_I	WXS	none	1		Illumina GAIIx	9c879ced-92e8-4292-9b24-46005acab0f4	69a46a7b-70d9-4789-b6ee-9a5971644d7e	g.chr16:69832690G>A	ENST00000359154.2	+	3	277	c.176G>A	c.(175-177)cGc>cAc	p.R59H	WWP2_ENST00000356003.2_Missense_Mutation_p.R59H|WWP2_ENST00000569174.1_Missense_Mutation_p.R59H|WWP2_ENST00000448661.1_Missense_Mutation_p.R59H	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	59	C2.				cellular protein modification process (GO:0006464)|negative regulation of gene expression (GO:0010629)|negative regulation of protein transport (GO:0051224)|negative regulation of sequence-specific DNA binding transcription factor activity (GO:0043433)|negative regulation of transcription from RNA polymerase II promoter (GO:0000122)|negative regulation of transcription, DNA-templated (GO:0045892)|negative regulation of transporter activity (GO:0032410)|proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)|protein autoubiquitination (GO:0051865)|protein K63-linked ubiquitination (GO:0070534)|protein ubiquitination (GO:0016567)|protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)|regulation of ion transmembrane transport (GO:0034765)|regulation of membrane potential (GO:0042391)|regulation of potassium ion transmembrane transporter activity (GO:1901016)|viral entry into host cell (GO:0046718)	cytoplasm (GO:0005737)|extracellular vesicular exosome (GO:0070062)|membrane (GO:0016020)|nucleus (GO:0005634)|ubiquitin ligase complex (GO:0000151)	ligase activity (GO:0016874)|RNA polymerase II transcription factor binding (GO:0001085)|transcription factor binding (GO:0008134)|ubiquitin-protein transferase activity (GO:0004842)			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ACTGGGAAGCGCATTGGGAGC	0.512											OREG0023909	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)																										dbGAP											0													140.0	142.0	142.0					16																	69832690		2198	4300	6498	-	-	-	SO:0001583	missense	0			BC013645	CCDS10885.1, CCDS58475.1, CCDS58476.1, CCDS58477.1	16q22.1	2008-02-05			ENSG00000198373	ENSG00000198373			16804	protein-coding gene	gene with protein product		602308				9169421, 12167593	Standard	NM_007014		Approved	AIP2	uc002exv.2	O00308	OTTHUMG00000137573	ENST00000359154.2:c.176G>A	16.37:g.69832690G>A	ENSP00000352069:p.Arg59His	Somatic	1117	WXS	Illumina GAIIx	Phase_IV	A6NEP1|B2R706|B4DTL5|F5H213|H3BRF3|I3RSG8|Q6ZTQ5|Q96CZ2|Q9BWN6	Missense_Mutation	SNP	pfam_HECT,pfam_WW_Rsp5_WWP,superfamily_HECT,superfamily_C2_Ca/lipid-bd_dom_CaLB,superfamily_WW_Rsp5_WWP,smart_C2_Ca-dep,smart_WW_Rsp5_WWP,smart_HECT,pfscan_HECT,pfscan_WW_Rsp5_WWP	p.R59H	ENST00000359154.2	37	c.176	CCDS10885.1	16	.	.	.	.	.	.	.	.	.	.	G	24.3	4.520394	0.85495	.	.	ENSG00000198373	ENST00000359154;ENST00000448661;ENST00000356003	T;T;T	0.66815	-0.23;-0.23;-0.23	6.03	6.03	0.97812	C2 calcium-dependent membrane targeting (1);C2 calcium/lipid-binding domain, CaLB (1);	0.058793	0.64402	D	0.000001	T	0.53948	0.1828	L	0.44542	1.39	0.80722	D	1	P	0.48350	0.909	B	0.36504	0.226	T	0.55642	-0.8109	9	.	.	.	.	11.4413	0.50099	0.0814:0.0:0.9186:0.0	.	59	O00308	WWP2_HUMAN	H	59	ENSP00000352069:R59H;ENSP00000396871:R59H;ENSP00000348283:R59H	.	R	+	2	0	WWP2	68390191	1.000000	0.71417	1.000000	0.80357	0.983000	0.72400	5.766000	0.68843	2.861000	0.98227	0.655000	0.94253	CGC	WWP2	-	superfamily_C2_Ca/lipid-bd_dom_CaLB,smart_C2_Ca-dep	ENSG00000198373		0.512	WWP2-001	KNOWN	basic|appris_principal|CCDS	protein_coding	WWP2	HGNC	protein_coding	OTTHUMT00000268954.1	265	0.38	1	G	NM_007014		69832690	69832690	+1	no_errors	ENST00000356003	ensembl	human	known	69_37n	missense	129	34.18	67	SNP	1.000	A
