Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
KAZ	23254	broad.mit.edu	37	1	14925658	14925658	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:14925658C>T	uc001avm.3	+	1	446	c.165C>T	c.(163-165)AGC>AGT	p.S55S	KAZ_uc009vog.1_Silent_p.S55S|KAZ_uc010obj.1_Silent_p.S55S	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	55					keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						ccgcggccagcgcctcggcgg	0.473		NA											3	4					0	0	0	0
IPO13	9670	broad.mit.edu	37	1	44415762	44415762	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:44415762C>T	uc001ckx.2	+	2	1553	c.758C>T	c.(757-759)TCG>TTG	p.S253L		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	253	HEAT 3.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CTGCAGGACTCGGAGCTCTTC	0.577		NA											12	27					0	0	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94342345	94342345	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:94342345G>A	uc001dqf.2	-	2	1184	c.1146C>T	c.(1144-1146)CCC>CCT	p.P382P	DNTTIP2_uc010otm.1_RNA|DNTTIP2_uc009wdo.1_Silent_p.P177P	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	382					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		TTGCTTTTATGGGGCTCTTTT	0.398		NA											139	171					0	0	0	0
DDX20	11218	broad.mit.edu	37	1	112309065	112309065	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:112309065C>T	uc001ebs.2	+	11	2376	c.2019C>T	c.(2017-2019)TAC>TAT	p.Y673Y	DDX20_uc010owf.1_Silent_p.Y435Y|DDX20_uc001ebt.2_Silent_p.Y281Y	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	673					assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATAAGTCATACTTGGAAGGCT	0.453		NA											14	43					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152276170	152276170	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:152276170G>A	uc001ezu.1	-	3	11228	c.11192C>T	c.(11191-11193)ACT>ATT	p.T3731I		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3731	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTTCCTCCAGTACTGGGCCC	0.617		NA							Ichthyosis				139	307					0	0	0	0
IVL	3713	broad.mit.edu	37	1	152883939	152883939	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:152883939C>T	uc001fau.2	+	2	1712	c.1666C>T	c.(1666-1668)CAA>TAA	p.Q556*		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	556					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCAAGACATTCAACCAGCCCT	0.388		NA											19	53					0	0	0	0
S100A2	6273	broad.mit.edu	37	1	153533987	153533987	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:153533987C>T	uc001fcb.2	-	3	560	c.222G>A	c.(220-222)GAG>GAA	p.E74E		NM_005978	NP_005969	P29034	S10A2_HUMAN	S100 calcium binding protein A2	75	EF-hand 2.|2; high affinity (Potential).				endothelial cell migration		calcium ion binding			ovary(1)	1	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAACAGCATACTCCTGGAAGT	0.527		NA											56	149					0	0	0	0
RAB13	5872	broad.mit.edu	37	1	153957221	153957221	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:153957221C>T	uc001fdt.1	-	2	255	c.161G>A	c.(160-162)GGG>GAG	p.G54E	RAB13_uc001fdu.1_Missense_Mutation_p.G54E	NM_002870	NP_002861	P51153	RAB13_HUMAN	RAB13, member RAS oncogene family	54					cell adhesion|protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	cytoplasmic vesicle membrane|tight junction	GTP binding|GTPase activity				0	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GATCTTCTTCCCCTCTATATC	0.448		NA											4	31					0	0	0	0
OR10J5	127385	broad.mit.edu	37	1	159505792	159505792	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:159505792C>G	uc010piw.1	-	1	6	c.6G>C	c.(4-6)AAG>AAC	p.K2N		NM_001004469	NP_001004469	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_hematologic(112;0.0429)					AGTTCTTTCTCTTCATTCTGC	0.348		NA											14	32					0	0	0	0
ATP1A2	477	broad.mit.edu	37	1	160109482	160109482	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:160109482C>A	uc001fvc.2	+	21	3025	c.2893C>A	c.(2893-2895)CTC>ATC	p.L965I	ATP1A2_uc001fvd.2_Missense_Mutation_p.L684I	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	965	Helical; (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GGCTGCCTTTCTCTCTTACTG	0.582		NA											18	51					6.5e-13	9.46e-13	1	0
RXRG	6258	broad.mit.edu	37	1	165378880	165378880	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:165378880C>T	uc001gda.2	-	7	1261	c.961G>A	c.(961-963)GTG>ATG	p.V321M		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	321	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CCATCCTGCACGGAAACTGAG	0.517		NA											8	21					0	0	0	0
PTPRC	5788	broad.mit.edu	37	1	198685828	198685828	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:198685828C>G	uc001gur.1	+	13	1483	c.1303C>G	c.(1303-1305)CTG>GTG	p.L435V	PTPRC_uc001gus.1_Missense_Mutation_p.L387V|PTPRC_uc001gut.1_Missense_Mutation_p.L274V|PTPRC_uc009wzf.1_Missense_Mutation_p.L323V|PTPRC_uc010ppg.1_Missense_Mutation_p.L371V	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	435	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TTGCCTCAATCTGGATAAAAA	0.303		NA											12	54					0	0	0	0
DUSP10	11221	broad.mit.edu	37	1	221913036	221913036	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:221913036G>A	uc001hmy.1	-	2	233	c.51C>T	c.(49-51)CCC>CCT	p.P17P	DUSP10_uc001hmx.1_5'Flank|DUSP10_uc001hmz.1_Intron	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	17					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		GAGGTCGGACGGGCCTAGATA	0.517		NA											33	76					0	0	0	0
KIAA1383	54627	broad.mit.edu	37	1	232941709	232941709	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr1:232941709A>G	uc001hvh.2	+	1	1072	c.940A>G	c.(940-942)ACT>GCT	p.T314A		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	172										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				GGGCGAGCGGACTGGGGACAT	0.692		NA											10	17					0	0	0	0
LYZL2	119180	broad.mit.edu	37	10	30900884	30900884	+	Nonstop_Mutation	SNP	T	T	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:30900884T>A	uc001ivk.2	-	5	598	c.585A>T	c.(583-585)TAA>TAT	p.*195Y		NM_183058	NP_898881	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	195					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Prostate(175;0.151)				CAGTTCCAGTTTAGGAAACCT	0.517		NA											81	156					0	0	0	0
ZNF438	220929	broad.mit.edu	37	10	31139092	31139092	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:31139092G>A	uc010qdz.1	-	7	677	c.242C>T	c.(241-243)GCC>GTC	p.A81V	ZNF438_uc001ivn.2_Missense_Mutation_p.A32V|ZNF438_uc010qdy.1_Missense_Mutation_p.A71V|ZNF438_uc001ivo.3_Intron|ZNF438_uc009xlg.2_Missense_Mutation_p.A81V|ZNF438_uc001ivp.3_Missense_Mutation_p.A71V|ZNF438_uc010qea.1_Missense_Mutation_p.A81V|ZNF438_uc010qeb.1_Missense_Mutation_p.A81V|ZNF438_uc010qec.1_Intron	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				CTGCATCAGGGCATAGTTCTG	0.532		NA											4	116					0	0	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508040	37508040	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:37508040G>A	uc001iza.1	+	34	3331	c.3232G>A	c.(3232-3234)GAG>AAG	p.E1078K		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1134	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TAAATACTTTGAGGACATTAA	0.338		NA											48	88					0	0	0	0
CYP2C8	1558	broad.mit.edu	37	10	96818118	96818118	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:96818118C>G	uc001kkb.2	-	5	888	c.793G>C	c.(793-795)GAT>CAT	p.D265H	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_Missense_Mutation_p.D195H|CYP2C8_uc010qob.1_Missense_Mutation_p.D179H|CYP2C8_uc010qoc.1_Missense_Mutation_p.D163H|CYP2C8_uc010qod.1_Missense_Mutation_p.D179H	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	265					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	AGGAAGCAATCGATAAAGTCC	0.358		NA											4	58					0	0	0	0
SLIT1	6585	broad.mit.edu	37	10	98770859	98770859	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:98770859C>T	uc001kmw.2	-	31	3484	c.3232G>A	c.(3232-3234)GAC>AAC	p.D1078N		NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	1078	EGF-like 4.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		CTGCAGTTGTCACCTGCATAA	0.607		NA											5	34					0	0	0	0
CCDC147	159686	broad.mit.edu	37	10	106113661	106113661	+	Silent	SNP	T	T	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:106113661T>A	uc001kyh.2	+	1	140	c.6T>A	c.(4-6)GCT>GCA	p.A2A		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	2										ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		TCAGGATGGCTGAGGTCAGGA	0.597		NA									OREG0020519	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	32					0	0	0	0
TACC2	10579	broad.mit.edu	37	10	123845099	123845099	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:123845099G>C	uc001lfv.2	+	4	3444	c.3084G>C	c.(3082-3084)TGG>TGC	p.W1028C	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.W1028C|TACC2_uc010qtv.1_Missense_Mutation_p.W1028C	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1028						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCCCACTCTGGGGCTTGAGTA	0.562		NA											12	41					0	0	0	0
FAM53B	9679	broad.mit.edu	37	10	126311927	126311927	+	Missense_Mutation	SNP	C	C	T	rs140442850	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr10:126311927C>T	uc001lhv.1	-	5	1676	c.1153G>A	c.(1153-1155)GAG>AAG	p.E385K	FAM53B_uc001lhu.1_Intron	NM_014661	NP_055476	Q14153	FA53B_HUMAN	hypothetical protein LOC9679	385										ovary(1)|pancreas(1)	2		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		CCACAATCCTCGTCCAGGGCG	0.682		NA											7	25					0	0	0	0
SIRT3	23410	broad.mit.edu	37	11	233115	233115	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:233115A>G	uc001lok.3	-	3	608	c.574T>C	c.(574-576)TTT>CTT	p.F192L	SIRT3_uc001loj.3_Missense_Mutation_p.F50L|SIRT3_uc010qvm.1_Missense_Mutation_p.F128L|SIRT3_uc010qvn.1_Missense_Mutation_p.F111L|SIRT3_uc010qvo.1_Missense_Mutation_p.F192L|SIRT3_uc010qvp.1_Missense_Mutation_p.F192L|SIRT3_uc010qvq.1_Missense_Mutation_p.F50L|SIRT3_uc009ybt.1_RNA	NM_012239	NP_036371	Q9NTG7	SIRT3_HUMAN	sirtuin 3 isoform a	192	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			urinary_tract(1)	1		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.66e-27)|Epithelial(43;2.02e-26)|OV - Ovarian serous cystadenocarcinoma(40;2.9e-21)|BRCA - Breast invasive adenocarcinoma(625;3.88e-05)|Lung(200;0.111)|LUSC - Lung squamous cell carcinoma(625;0.129)		AAAGTGAAAAAGGGCTTGGGG	0.547		NA											3	61					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1271273	1271273	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:1271273C>T	uc009ycr.1	+	51	14708	c.14582C>T	c.(14581-14583)ACG>ATG	p.T4861M	MUC5B_uc001ltb.2_Missense_Mutation_p.T4391M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4388	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACTCCGGGGACGACCTGGATC	0.662		NA											55	129					0	0	0	0
OR52H1	390067	broad.mit.edu	37	11	5566547	5566547	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:5566547G>C	uc010qzh.1	-	1	207	c.207C>G	c.(205-207)TTC>TTG	p.F69L	HBG2_uc001mak.1_Intron	NM_001005289	NP_001005289	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGAGAGAAAGAAGAACATGG	0.473		NA											19	55					0	0	0	0
OR10A2	341276	broad.mit.edu	37	11	6891450	6891450	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:6891450C>T	uc001meu.1	+	1	465	c.465C>T	c.(463-465)TTC>TTT	p.F155F		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	155	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GTTTTCCATTCTGTGGCACCA	0.537		NA											33	114					0	0	0	0
SLC1A2	6506	broad.mit.edu	37	11	35308446	35308446	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:35308446C>G	uc001mwd.2	-	8	1736	c.1144G>C	c.(1144-1146)GAT>CAT	p.D382H	SLC1A2_uc001mwe.2_Missense_Mutation_p.D373H|SLC1A2_uc010rev.1_Missense_Mutation_p.D382H	NM_004171	NP_004162	P43004	EAA2_HUMAN	excitatory amino acid transporter 2	382					D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|central_nervous_system(1)	3	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	ACACGCTTATCAATCCCCAGA	0.458		NA											39	124					0	0	0	0
MS4A2	2206	broad.mit.edu	37	11	59857261	59857261	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:59857261G>A	uc001nop.2	+	2	255	c.153G>A	c.(151-153)CTG>CTA	p.L51L	MS4A2_uc009ymu.2_Silent_p.L51L	NM_000139	NP_000130	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member	51	Cytoplasmic (Potential).				cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			ovary(1)	1		all_epithelial(135;0.245)			Omalizumab(DB00043)	ATACATGGCTGACAGTTTTGA	0.468		NA											23	44					0	0	0	0
C11orf51	25906	broad.mit.edu	37	11	71822259	71822259	+	Silent	SNP	G	G	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:71822259G>T	uc001orw.2	-	3	286	c.64C>A	c.(64-66)CGA>AGA	p.R22R	C11orf51_uc009ytc.1_Intron|C11orf51_uc001orv.2_Silent_p.R22R	NM_014042	NP_054761	P60006	CK051_HUMAN	hypothetical protein LOC25906	22						intracellular					0						ACACAGGGTCGATCCAGATTA	0.542		NA											37	67					2.42e-17	3.55e-17	1	0
CCDC83	220047	broad.mit.edu	37	11	85597249	85597249	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:85597249G>A	uc001pbh.1	+	5	862	c.350G>A	c.(349-351)CGC>CAC	p.R117H	CCDC83_uc001pbg.1_Missense_Mutation_p.R117H|CCDC83_uc001pbi.1_RNA|CCDC83_uc001pbj.1_Intron	NM_173556	NP_775827	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	117	Potential.									skin(1)	1		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				ACAGATATGCGCATGCAAATA	0.333		NA											6	15					0	0	0	0
GPR83	10888	broad.mit.edu	37	11	94134045	94134045	+	Silent	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:94134045G>C	uc001pet.2	-	1	541	c.369C>G	c.(367-369)CTC>CTG	p.L123L		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	123	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				AGGGGGTGTTGAGCAGCGTGA	0.438		NA											12	28					0	0	0	0
ROBO3	64221	broad.mit.edu	37	11	124750348	124750348	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:124750348C>T	uc001qbc.2	+	27	4185	c.3993C>T	c.(3991-3993)TTC>TTT	p.F1331F	ROBO3_uc001qbd.2_Silent_p.F256F|ROBO3_uc010sar.1_Silent_p.F380F|ROBO3_uc001qbe.2_Silent_p.F256F|ROBO3_uc001qbf.1_Silent_p.F215F	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	1331	Cytoplasmic (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		GACCAAGCTTCCTGTCCCGGG	0.622		NA											10	17					0	0	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128838895	128838895	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:128838895C>G	uc009zcp.2	-	22	6171	c.6171G>C	c.(6169-6171)CAG>CAC	p.Q2057H	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Missense_Mutation_p.Q1016H|ARHGAP32_uc001qez.2_Missense_Mutation_p.Q1708H	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	2057	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						AGGTCCTGCTCTGTGGATGGG	0.587		NA											7	25					0	0	0	0
IGSF9B	22997	broad.mit.edu	37	11	133792107	133792107	+	Silent	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr11:133792107G>C	uc001qgx.3	-	17	2523	c.2292C>G	c.(2290-2292)CTC>CTG	p.L764L		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	764	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GGGTGATGGAGAGTGGAGGGT	0.602		NA											4	16					0	0	0	0
CCND2	894	broad.mit.edu	37	12	4409145	4409145	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:4409145C>T	uc001qmo.2	+	5	1145	c.840C>T	c.(838-840)ACC>ACT	p.T280T		NM_001759	NP_001750	P30279	CCND2_HUMAN	cyclin D2	280					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			haematopoietic_and_lymphoid_tissue(1)|breast(1)|kidney(1)	3			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			AAGCCAGCACCCCTACAGACG	0.547		NA	T	IGL@	NHL,CLL								3	29					0	0	0	0
GRIN2B	2904	broad.mit.edu	37	12	13722780	13722780	+	Silent	SNP	C	C	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:13722780C>A	uc001rbt.2	-	11	2522	c.2343G>T	c.(2341-2343)CTG>CTT	p.L781L		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	781	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CAAAGAGCTGCAGGATAGCAA	0.488		NA											18	46					1.34e-09	1.92e-09	1	0
TBX5	6910	broad.mit.edu	37	12	114804166	114804166	+	Silent	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:114804166G>C	uc001tvo.2	-	8	1281	c.786C>G	c.(784-786)ACC>ACG	p.T262T	TBX5_uc001tvp.2_Silent_p.T262T|TBX5_uc001tvq.2_Silent_p.T212T|TBX5_uc010syv.1_Silent_p.T262T	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	262					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TTTGCCTCACGGTGCTCCTGG	0.512		NA											4	88					0	0	0	0
RNF10	9921	broad.mit.edu	37	12	120972767	120972767	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:120972767G>C	uc001typ.3	+	1	636	c.153G>C	c.(151-153)AAG>AAC	p.K51N	RNF10_uc010szk.1_RNA	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	51	Ser-rich.				negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTAAACCCAAGAGCGGTAAGG	0.701		NA											8	26					0	0	0	0
ORAI1	84876	broad.mit.edu	37	12	122079382	122079382	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:122079382G>A	uc010szz.1	+	3	932	c.739G>A	c.(739-741)GGC>AGC	p.G247S		NM_032790	NP_116179	Q96D31	CRCM1_HUMAN	calcium release-activated calcium channel	247	Helical; (Potential).				platelet activation|positive regulation of calcium ion transport	integral to plasma membrane	protein binding|store-operated calcium channel activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000415)|Epithelial(86;0.00148)		GGTGCCCTTCGGCCTGATCTT	0.627		NA											28	56					0	0	0	0
MYCBP2	23077	broad.mit.edu	37	13	77715011	77715011	+	Silent	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr13:77715011G>C	uc001vkf.2	-	51	7348	c.7257C>G	c.(7255-7257)GTC>GTG	p.V2419V	MYCBP2_uc010aev.2_Silent_p.V1823V	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2419					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ACTTTGGTTTGACCAACTGAG	0.408		NA											66	179					0	0	0	0
OR4K2	390431	broad.mit.edu	37	14	20345329	20345329	+	Silent	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr14:20345329G>C	uc001vwh.1	+	1	903	c.903G>C	c.(901-903)CTG>CTC	p.L301L		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGAGGAAACTGAAAAATAGGT	0.348		NA											20	20					0	0	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36097115	36097115	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr14:36097115C>T	uc001wti.2	-	33	4911	c.4520G>A	c.(4519-4521)CGC>CAC	p.R1507H	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.R1507H|RALGAPA1_uc010tpv.1_Missense_Mutation_p.R1520H|RALGAPA1_uc010tpw.1_Missense_Mutation_p.R1554H	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1507	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						AATAACAGTGCGGGCTGCTAT	0.398		NA											45	35					0	0	0	0
TJP1	7082	broad.mit.edu	37	15	30011032	30011032	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:30011032G>C	uc001zcr.2	-	21	3789	c.3314C>G	c.(3313-3315)CCT>CGT	p.P1105R	TJP1_uc010azl.2_Missense_Mutation_p.P1093R|TJP1_uc001zcq.2_Missense_Mutation_p.P1029R|TJP1_uc001zcs.2_Missense_Mutation_p.P1025R	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1105					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		ATTATCAAAAGGTGGCCGAGA	0.493		NA											4	162					0	0	0	0
EHD4	30844	broad.mit.edu	37	15	42192864	42192864	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:42192864C>A	uc001zot.2	-	6	1668	c.1605G>T	c.(1603-1605)AAG>AAT	p.K535N		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	535	EH.				endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		TGGGCAGGGACTTCCTGTGCG	0.453		NA											11	10					3.86e-05	5.35e-05	1	0
SH3GL3	6457	broad.mit.edu	37	15	84286874	84286874	+	Silent	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:84286874C>G	uc002bjw.2	+	9	1074	c.879C>G	c.(877-879)CTC>CTG	p.L293L	SH3GL3_uc002bjx.2_Silent_p.L224L|SH3GL3_uc002bju.2_Silent_p.L301L|SH3GL3_uc002bjv.2_RNA	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	293	SH3.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			pancreas(1)|central_nervous_system(1)|skin(1)	3						GTCGTGGTCTCTATGACTTTG	0.398		NA											20	49					0	0	0	0
PDE8A	5151	broad.mit.edu	37	15	85669605	85669605	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:85669605G>A	uc002blh.2	+	20	2442	c.2253G>A	c.(2251-2253)CAG>CAA	p.Q751Q	PDE8A_uc002bli.2_Silent_p.Q705Q|PDE8A_uc010bnc.2_Silent_p.Q504Q|PDE8A_uc010bnd.2_Silent_p.Q504Q|PDE8A_uc002blj.2_Silent_p.Q371Q|PDE8A_uc002blk.2_Silent_p.Q371Q|PDE8A_uc002bll.2_Silent_p.Q103Q	NM_002605	NP_002596	O60658	PDE8A_HUMAN	phosphodiesterase 8A isoform 1	751	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			ATTTTTCTCAGGTAAGTTGCT	0.413		NA											18	58					0	0	0	0
AGBL1	123624	broad.mit.edu	37	15	86687068	86687068	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:86687068G>A	uc002blz.1	+	2	196	c.116G>A	c.(115-117)GGC>GAC	p.G39D		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	39					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						GCCAAAGTTGGCCTAAGAGGT	0.522		NA											17	39					0	0	0	0
C15orf42	90381	broad.mit.edu	37	15	90143870	90143870	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr15:90143870C>T	uc002boe.2	+	9	2107	c.2107C>T	c.(2107-2109)CGA>TGA	p.R703*		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	703					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TAAAAGTCTTCGACAGAATCT	0.303		NA											6	19					0	0	0	0
PDIA2	64714	broad.mit.edu	37	16	335330	335330	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:335330G>A	uc002cgn.1	+	11	1922	c.814G>A	c.(814-816)GCG>ACG	p.A272T	PDIA2_uc010bqt.1_Missense_Mutation_p.A117T|PDIA2_uc002cgo.1_Missense_Mutation_p.A272T	NM_006849	NP_006840	Q13087	PDIA2_HUMAN	protein disulfide isomerase A2 precursor	272					apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			central_nervous_system(1)|skin(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				CAAGATCTTCGCGGCCAGGAT	0.642		NA											11	40					0	0	0	0
FBXL16	146330	broad.mit.edu	37	16	745785	745785	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:745785C>T	uc002cjc.2	-	4	975	c.772G>A	c.(772-774)GAC>AAC	p.D258N	FBXL16_uc002cja.2_5'Flank|FBXL16_uc002cjb.2_Missense_Mutation_p.D46N	NM_153350	NP_699181	Q8N461	FXL16_HUMAN	F-box and leucine-rich repeat protein 16	258	LRR 1.										0		Hepatocellular(780;0.0218)				GCGATGGCGTCGTCGGCCACG	0.687		NA											20	30					0	0	0	0
SH2B1	25970	broad.mit.edu	37	16	28883683	28883683	+	Silent	SNP	T	T	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:28883683T>G	uc002dri.2	+	9	2125	c.1686T>G	c.(1684-1686)GGT>GGG	p.G562G	uc010vct.1_Intron|SH2B1_uc010vdc.1_Silent_p.G252G|SH2B1_uc002drj.2_Silent_p.G562G|SH2B1_uc002drk.2_Silent_p.G562G|SH2B1_uc002drl.2_Silent_p.G562G|SH2B1_uc010vdd.1_Silent_p.G226G|SH2B1_uc010vde.1_Silent_p.G562G|SH2B1_uc002drm.2_Silent_p.G562G	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	562	SH2.				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						CAAGGCGGGGTGAATACGTCC	0.612		NA											4	60					0	0	0	0
ATP2A1	487	broad.mit.edu	37	16	28906160	28906160	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:28906160G>A	uc002dro.1	+	12	1489	c.1305G>A	c.(1303-1305)GAG>GAA	p.E435E	uc010vct.1_Intron|ATP2A1_uc002drn.1_Silent_p.E435E|ATP2A1_uc002drp.1_Silent_p.E310E	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	435	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GTGTCTATGAGAAGGTCGGCG	0.567		NA											17	41					0	0	0	0
ZNF668	79759	broad.mit.edu	37	16	31073297	31073297	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:31073297G>A	uc010caf.2	-	3	1309	c.952C>T	c.(952-954)CGG>TGG	p.R318W	ZNF668_uc002eao.2_Missense_Mutation_p.R318W	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	318	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						GCCGGCTGCCGGAAGTCCTTG	0.662		NA											10	34					0	0	0	0
TMCO7	79613	broad.mit.edu	37	16	69007962	69007962	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:69007962G>C	uc002ewi.3	+	15	2745	c.2733G>C	c.(2731-2733)GAG>GAC	p.E911D		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	911						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		TCTATCCTGAGAAAATCTTGC	0.458		NA											11	23					0	0	0	0
MTHFSD	64779	broad.mit.edu	37	16	86580199	86580199	+	Silent	SNP	T	T	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr16:86580199T>C	uc002fjn.2	-	5	459	c.408A>G	c.(406-408)TTA>TTG	p.L136L	MTHFSD_uc010voo.1_Silent_p.L116L|MTHFSD_uc002fjo.2_5'UTR|MTHFSD_uc002fjm.2_Silent_p.L135L|MTHFSD_uc010vop.1_5'UTR|MTHFSD_uc010voq.1_Silent_p.L135L|MTHFSD_uc010vor.1_Silent_p.L136L|MTHFSD_uc002fjp.2_Silent_p.L116L	NM_001159377	NP_001152849	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain	136					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding				0						CCACCACAACTAAATCCACGA	0.537		NA											3	101					0	0	0	0
TRPV1	7442	broad.mit.edu	37	17	3475479	3475479	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:3475479G>A	uc010vrr.1	-	13	2695	c.2168C>T	c.(2167-2169)TCA>TTA	p.S723L	TRPV1_uc010vro.1_Missense_Mutation_p.S734L|TRPV1_uc010vrp.1_Missense_Mutation_p.S663L|TRPV1_uc010vrq.1_Missense_Mutation_p.S721L|TRPV1_uc010vrs.1_Missense_Mutation_p.S723L|TRPV1_uc010vrt.1_Missense_Mutation_p.S723L|TRPV1_uc010vru.1_Missense_Mutation_p.S723L	NM_080706	NP_542437	Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel,	723	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			ovary(1)	1				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	CAGCTTGCCTGAGCGGAAGGC	0.592		NA											7	22					0	0	0	0
RNF167	26001	broad.mit.edu	37	17	4847869	4847869	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:4847869C>T	uc002fzq.2	+	10	1103	c.687C>T	c.(685-687)GTC>GTT	p.V229V	RNF167_uc002fzr.2_Silent_p.V229V|RNF167_uc002fzs.2_Silent_p.V229V|RNF167_uc002fzt.2_Silent_p.V229V|RNF167_uc002fzu.2_Silent_p.V228V|RNF167_uc002fzv.2_Silent_p.V194V|RNF167_uc002fzx.2_Silent_p.V193V|RNF167_uc002fzy.2_Missense_Mutation_p.S3F	NM_015528	NP_056343	Q9H6Y7	RN167_HUMAN	ring finger protein 167 precursor	229					negative regulation of cell cycle|protein polyubiquitination	cytoplasm|endomembrane system|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						AGTATGATGTCTGTGCCATTT	0.517		NA											20	84					0	0	0	0
USP6	9098	broad.mit.edu	37	17	5048764	5048764	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:5048764G>A	uc002gau.1	+	27	4287	c.2057G>A	c.(2056-2058)AGA>AAA	p.R686K	USP6_uc002gav.1_Missense_Mutation_p.R686K|USP6_uc010ckz.1_Missense_Mutation_p.R369K	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	686					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						GGGCAGCTAAGATCTCAAGTC	0.373		NA	T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								19	47					0	0	0	0
LLGL1	3996	broad.mit.edu	37	17	18144788	18144788	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:18144788C>T	uc002gsp.2	+	18	2587	c.2526C>T	c.(2524-2526)AGC>AGT	p.S842S		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	842	WD 12.				cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)					CCAAGGTGAGCGCGAAGACCA	0.632		NA											11	29					0	0	0	0
SHMT1	6470	broad.mit.edu	37	17	18244076	18244076	+	Missense_Mutation	SNP	G	G	A	rs148701087	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:18244076G>A	uc002gta.2	-	6	761	c.571C>T	c.(571-573)CGC>TGC	p.R191C	SHMT1_uc002gsz.2_Translation_Start_Site|SHMT1_uc002gtb.2_Missense_Mutation_p.R191C|SHMT1_uc010cqb.2_Missense_Mutation_p.R191C|SHMT1_uc010vxt.1_Missense_Mutation_p.R53C|SHMT1_uc002gtd.1_Missense_Mutation_p.R191C|SHMT1_uc010vxu.1_Missense_Mutation_p.R191C	NM_004169	NP_004160	P34896	GLYC_HUMAN	serine hydroxymethyltransferase 1 (soluble)	191					carnitine biosynthetic process|folic acid metabolic process|L-serine catabolic process|one-carbon metabolic process|purine base biosynthetic process	cytosol|nucleus	glycine hydroxymethyltransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					Glycine(DB00145)|Mimosine(DB01055)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	TGGAAGAGGCGTGCGTTCTCC	0.557		NA											5	12					0	0	0	0
MED1	5469	broad.mit.edu	37	17	37576168	37576168	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:37576168G>C	uc002hrv.3	-	14	1311	c.1099C>G	c.(1099-1101)CTT>GTT	p.L367V	MED1_uc010wee.1_Missense_Mutation_p.L195V|MED1_uc002hru.2_Missense_Mutation_p.L367V	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	367	Interaction with ESR1.|Interaction with the Mediator complex.|Interaction with the Mediator complex and THRA.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TGACCAGGAAGAGCCTGGGCA	0.433		NA								HNSCC(31;0.082)			23	36					0	0	0	0
SMARCE1	6605	broad.mit.edu	37	17	38785063	38785063	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:38785063T>C	uc002hux.2	-	11	1334	c.1210A>G	c.(1210-1212)ATA>GTA	p.I404V	SMARCE1_uc010wff.1_3'UTR|SMARCE1_uc010wfg.1_3'UTR|SMARCE1_uc002huy.2_Missense_Mutation_p.I369V|SMARCE1_uc010wfh.1_Missense_Mutation_p.I334V|SMARCE1_uc010wfi.1_Missense_Mutation_p.I386V	NM_003079	NP_003070	Q969G3	SMCE1_HUMAN	SWI/SNF-related matrix-associated	404	Glu-rich.				chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity				0		Breast(137;0.000812)				TCTTCTGGTATGGGATCTGTT	0.418		NA											64	131					0	0	0	0
FZD2	2535	broad.mit.edu	37	17	42635585	42635585	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:42635585G>A	uc002igx.1	+	1	661	c.529G>A	c.(529-531)GGG>AGG	p.G177R		NM_001466	NP_001457	Q14332	FZD2_HUMAN	frizzled 2 precursor	177	Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		gccgggtgccgggggcacccc	0.418		NA											5	13					0	0	0	0
KIAA1267	284058	broad.mit.edu	37	17	44248386	44248386	+	Nonsense_Mutation	SNP	G	G	C	rs142696045	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:44248386G>C	uc002ikb.2	-	1	1209	c.1124C>G	c.(1123-1125)TCA>TGA	p.S375*	KIAA1267_uc002ikc.2_Nonsense_Mutation_p.S375*|KIAA1267_uc002ikd.2_Nonsense_Mutation_p.S375*|KIAA1267_uc010dav.2_Nonsense_Mutation_p.S375*	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	375						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				TTCTGAAATTGAATTGCTTTT	0.453		NA											23	121					0	0	0	0
DGKE	8526	broad.mit.edu	37	17	54940147	54940147	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:54940147G>T	uc002iur.2	+	12	1879	c.1699G>T	c.(1699-1701)GAA>TAA	p.E567*	DGKE_uc002ius.1_3'UTR	NM_003647	NP_003638	P52429	DGKE_HUMAN	diacylglycerol kinase epsilon	567					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(2)	2	Breast(9;3.59e-07)					AAAGGCGACTGAATAGATGGA	0.358		NA											10	17					2.18e-05	3.04e-05	1	0
ITGB4	3691	broad.mit.edu	37	17	73751885	73751885	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:73751885G>A	uc002jpg.2	+	35	4849	c.4662G>A	c.(4660-4662)GAG>GAA	p.E1554E	ITGB4_uc002jph.2_Silent_p.E1484E|ITGB4_uc002jpi.3_Silent_p.E1484E|ITGB4_uc002jpj.2_Silent_p.E1537E|GALK1_uc010wsi.1_Intron	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1554	Cytoplasmic (Potential).|Fibronectin type-III 3.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGCGGTGCGAGCGGCCGCTGC	0.701		NA											11	25					0	0	0	0
PQLC1	80148	broad.mit.edu	37	18	77710917	77710917	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr18:77710917C>G	uc002lnl.2	-	2	182	c.10G>C	c.(10-12)GAG>CAG	p.E4Q	PQLC1_uc010dre.2_5'UTR|PQLC1_uc002lnk.2_Missense_Mutation_p.E4Q|PQLC1_uc010xfm.1_Missense_Mutation_p.E4Q	NM_025078	NP_079354	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1 isoform 1	4						integral to membrane				large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		TCCAGGCCCTCGGCCTCCATC	0.766		NA											3	6					0	0	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456154	5456154	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:5456154G>A	uc002mca.3	+	1	729	c.652G>A	c.(652-654)GCC>ACC	p.A218T		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	218	Extracellular (Potential).|PA.					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GAGCGAGGCCGCCTCGCAGGA	0.672		NA											34	74					0	0	0	0
SMARCA4	6597	broad.mit.edu	37	19	11132522	11132522	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:11132522C>T	uc002mqf.3	+	19	3022	c.2738C>T	c.(2737-2739)CCG>CTG	p.P913L	SMARCA4_uc010dxp.2_Missense_Mutation_p.P913L|SMARCA4_uc010dxo.2_Missense_Mutation_p.P913L|SMARCA4_uc002mqg.1_Missense_Mutation_p.P913L|SMARCA4_uc010dxq.2_Missense_Mutation_p.P913L|SMARCA4_uc010dxr.2_Missense_Mutation_p.P913L|SMARCA4_uc002mqj.3_Missense_Mutation_p.P913L|SMARCA4_uc010dxs.2_Missense_Mutation_p.P913L|SMARCA4_uc010dxt.1_Missense_Mutation_p.P133L|SMARCA4_uc002mqh.3_Missense_Mutation_p.P36L|SMARCA4_uc002mqi.1_Missense_Mutation_p.P116L	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	913	Helicase ATP-binding.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				ACGGGCACACCGCTGCAGAAC	0.612		NA	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				12	44					0	0	0	0
NOTCH3	4854	broad.mit.edu	37	19	15290215	15290215	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:15290215G>A	uc002nan.2	-	21	3496	c.3420C>T	c.(3418-3420)CTC>CTT	p.L1140L	NOTCH3_uc002nao.1_Silent_p.L1088L	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1140	Extracellular (Potential).|EGF-like 29; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			AGCGGGCCACGAGGTCAATGC	0.602		NA											12	37					0	0	0	0
CEACAM6	4680	broad.mit.edu	37	19	42260628	42260628	+	Missense_Mutation	SNP	G	G	A	rs145319104		TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:42260628G>A	uc002orm.2	+	2	334	c.185G>A	c.(184-186)CGT>CAT	p.R62H		NM_002483	NP_002474	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion	62	Ig-like V-type.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		CCCCAGAATCGTATTGGTTAC	0.512		NA											6	189					0	0	0	0
RUVBL2	10856	broad.mit.edu	37	19	49507659	49507659	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:49507659G>C	uc002plr.1	+	4	262	c.249G>C	c.(247-249)AAG>AAC	p.K83N	RUVBL2_uc002plq.1_Missense_Mutation_p.K38N|RUVBL2_uc010yab.1_Missense_Mutation_p.K83N|RUVBL2_uc002pls.1_RNA|RUVBL2_uc010emn.1_Missense_Mutation_p.K38N|RUVBL2_uc010yac.1_Missense_Mutation_p.K38N	NM_006666	NP_006657	Q9Y230	RUVB2_HUMAN	RuvB-like 2	83	ATP.				cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		GCACGGGGAAGACGGCCATCG	0.537		NA											14	60					0	0	0	0
PRR12	57479	broad.mit.edu	37	19	50098966	50098966	+	Silent	SNP	G	G	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:50098966G>T	uc002poo.3	+	4	1374	c.1374G>T	c.(1372-1374)GGG>GGT	p.G458G		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	207	Pro-rich.						DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		AGGCCTACGGGCAAGGGTTTG	0.711		NA											7	20					0.00198382	0.00270109	1	0
MYBPC2	4606	broad.mit.edu	37	19	50958903	50958903	+	Splice_Site	SNP	T	T	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr19:50958903T>C	uc002psf.2	+	20	2389	c.2338_splice	c.e20+2	p.S780_splice		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type						cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		TGGAAGGCTGTGAGTGACCCT	0.602		NA											31	46					0	0	0	0
C2orf44	80304	broad.mit.edu	37	2	24261267	24261267	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:24261267G>C	uc002rep.2	-	2	1229	c.1098C>G	c.(1096-1098)ATC>ATG	p.I366M	C2orf44_uc010eya.2_Missense_Mutation_p.I366M	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	366							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGACAGAGTAGATCAAAATTA	0.393		NA											20	65					0	0	0	0
C2orf44	80304	broad.mit.edu	37	2	24261335	24261335	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:24261335G>A	uc002rep.2	-	2	1161	c.1030C>T	c.(1030-1032)CTG>TTG	p.L344L	C2orf44_uc010eya.2_Silent_p.L344L	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	344							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AATGCTATCAGATCAGGAACC	0.413		NA											16	44					0	0	0	0
C2orf44	80304	broad.mit.edu	37	2	24261747	24261747	+	Silent	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:24261747G>C	uc002rep.2	-	2	749	c.618C>G	c.(616-618)GTC>GTG	p.V206V	C2orf44_uc010eya.2_Silent_p.V206V	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	206							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATGGAGCAGACGTGGCTGT	0.488		NA											15	47					0	0	0	0
ALK	238	broad.mit.edu	37	2	29443686	29443686	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:29443686C>G	uc002rmy.2	-	23	4438	c.3531G>C	c.(3529-3531)CAG>CAC	p.Q1177H	ALK_uc010ymo.1_Missense_Mutation_p.Q109H	NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	1177	Protein kinase.|Cytoplasmic (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GAACAATGTTCTGGTGGTTGA	0.517		NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				13	28					0	0	0	0
SMEK2	57223	broad.mit.edu	37	2	55812192	55812192	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:55812192C>T	uc002rzc.2	-	7	1603	c.1228G>A	c.(1228-1230)GAT>AAT	p.D410N	SMEK2_uc002rzb.2_Missense_Mutation_p.D410N|SMEK2_uc002rzd.2_Missense_Mutation_p.D410N|SMEK2_uc002rza.2_Missense_Mutation_p.D286N	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	410						microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CTTACGTCATCACTCTGCTGA	0.348		NA											15	48					0	0	0	0
TMEM131	23505	broad.mit.edu	37	2	98408979	98408979	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:98408979C>T	uc002syh.3	-	31	4243	c.4014G>A	c.(4012-4014)GCG>GCA	p.A1338A		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1338						integral to membrane				ovary(4)|central_nervous_system(2)	6						AACTGTGCCTCGCGCTGCTGG	0.622		NA											5	22					0	0	0	0
COL5A2	1290	broad.mit.edu	37	2	189953461	189953461	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:189953461G>C	uc002uqk.2	-	8	880	c.605C>G	c.(604-606)TCT>TGT	p.S202C	COL5A2_uc010frx.2_5'Flank	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	202					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCCAAGTCCAGATTTTTCATC	0.353		NA											18	49					0	0	0	0
SP140	11262	broad.mit.edu	37	2	231112687	231112687	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr2:231112687G>A	uc002vql.2	+	8	914	c.799G>A	c.(799-801)GAG>AAG	p.E267K	SP140_uc010zma.1_Intron|SP140_uc002vqk.2_Missense_Mutation_p.E267K|SP140_uc002vqn.2_Intron|SP140_uc002vqm.2_Missense_Mutation_p.E241K|SP140_uc010fxl.2_Missense_Mutation_p.E267K	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	267					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGCACCAGGGGAGAAACAGGG	0.473		NA											46	38					0	0	0	0
GGTLC1	92086	broad.mit.edu	37	20	23966391	23966391	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:23966391G>A	uc002wts.2	-	5	577	c.444C>T	c.(442-444)GGC>GGT	p.G148G	GGTLC1_uc002wtu.2_Silent_p.G148G	NM_178312	NP_842564	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	148							gamma-glutamyltransferase activity			ovary(1)	1						TCACGTCATAGCCGAACCAGA	0.612		NA											38	142					0	0	0	0
GGTLC1	92086	broad.mit.edu	37	20	23967230	23967230	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:23967230A>C	uc002wts.2	-	2	152	c.19T>G	c.(19-21)TCT>GCT	p.S7A	GGTLC1_uc002wtu.2_Missense_Mutation_p.S7A	NM_178312	NP_842564	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	7							gamma-glutamyltransferase activity			ovary(1)	1						AGCTGGGCAGAGAAGAACTCG	0.642		NA											3	83					0	0	0	0
RBL1	5933	broad.mit.edu	37	20	35695460	35695460	+	Silent	SNP	A	A	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:35695460A>G	uc002xgi.2	-	5	700	c.621T>C	c.(619-621)GAT>GAC	p.D207D	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Silent_p.D207D|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	207					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				CAAAAATCAGATCCAAGCAGC	0.303		NA											25	68					0	0	0	0
SEMG1	6406	broad.mit.edu	37	20	43837187	43837187	+	Missense_Mutation	SNP	C	C	A	rs145325570	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:43837187C>A	uc002xni.2	+	2	1306	c.1249C>A	c.(1249-1251)CTA>ATA	p.L417I	SEMG1_uc002xnj.2_Missense_Mutation_p.L357I|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Missense_Mutation_p.L357I	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	417	42 AA repeat 3.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				AGAACAAGACCTACTCAGTCA	0.438		NA											21	48					4.97e-08	7.04e-08	1	0
DSCAM	1826	broad.mit.edu	37	21	41710050	41710050	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr21:41710050C>G	uc002yyq.1	-	8	2213	c.1761G>C	c.(1759-1761)CAG>CAC	p.Q587H	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	587	Extracellular (Potential).|Ig-like C2-type 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CGTGGACGCTCTGGCTGGTGG	0.507		NA											12	102					0	0	0	0
LZTR1	8216	broad.mit.edu	37	22	21348988	21348988	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr22:21348988C>T	uc002zto.2	+	15	1860	c.1757C>T	c.(1756-1758)GCC>GTC	p.A586V	LZTR1_uc002ztn.2_Missense_Mutation_p.A545V|LZTR1_uc011ahy.1_Missense_Mutation_p.A567V|LZTR1_uc002ztp.2_5'Flank	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	586					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TGCGAGAGTGCCGCCCGGCTG	0.657		NA											3	31					0	0	0	0
PRRT3	285368	broad.mit.edu	37	3	9989488	9989488	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:9989488G>A	uc003bul.2	-	4	1499	c.1369C>T	c.(1369-1371)CCG>TCG	p.P457S	CIDEC_uc003bto.2_Intron|PRRT3_uc003buk.2_RNA	NM_207351	NP_997234	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3 precursor	457	Extracellular (Potential).|Pro-rich.					integral to membrane					0						CAGCGTAGCGGGGGTGCAGTG	0.716		NA											3	5					0	0	0	0
ZNF621	285268	broad.mit.edu	37	3	40570902	40570902	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:40570902G>A	uc003ckm.2	+	3	333	c.117G>A	c.(115-117)GTG>GTA	p.V39V	ZNF621_uc003ckn.2_Silent_p.V39V|ZNF621_uc003cko.2_Intron|ZNF621_uc011aze.1_Intron	NM_001098414	NP_001091884	Q6ZSS3	ZN621_HUMAN	zinc finger protein 621	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0515)|Kidney(284;0.0648)		ACGGGGAGGTGATGCTGGAGA	0.517		NA											57	85					0	0	0	0
CLDND1	56650	broad.mit.edu	37	3	98240146	98240146	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:98240146T>G	uc003dsp.2	-	2	1003	c.123A>C	c.(121-123)GAA>GAC	p.E41D	CLDND1_uc003dso.2_Missense_Mutation_p.E41D|CLDND1_uc003dsq.2_Missense_Mutation_p.E41D|CLDND1_uc003dss.2_Missense_Mutation_p.E41D|CLDND1_uc003dsr.2_Intron|CLDND1_uc003dst.2_Missense_Mutation_p.E64D|CLDND1_uc003dsu.2_Missense_Mutation_p.E41D|CLDND1_uc003dsv.2_Missense_Mutation_p.E41D	NM_019895	NP_063948	Q9NY35	CLDN1_HUMAN	claudin domain containing 1 protein isoform a	41						integral to membrane				ovary(1)	1						CACTGGAATTTTCTTGAACTG	0.393		NA											15	46					0	0	0	0
ARGFX	503582	broad.mit.edu	37	3	121303817	121303817	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:121303817G>C	uc003eef.2	+	4	369	c.274G>C	c.(274-276)GAG>CAG	p.E92Q		NM_001012659	NP_001012677	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	92	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(114;0.152)		ACAGTATGAGGAGCTAGAAGC	0.443		NA											30	116					0	0	0	0
MYLK	4638	broad.mit.edu	37	3	123383036	123383036	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:123383036G>A	uc003ego.2	-	23	4183	c.3901C>T	c.(3901-3903)CGC>TGC	p.R1301C	MYLK_uc010hrr.2_5'UTR|MYLK_uc011bjv.1_Missense_Mutation_p.R101C|MYLK_uc011bjw.1_Missense_Mutation_p.R1301C|MYLK_uc003egp.2_Missense_Mutation_p.R1232C|MYLK_uc003egq.2_Missense_Mutation_p.R1301C|MYLK_uc003egr.2_Missense_Mutation_p.R1232C|MYLK_uc003egs.2_Missense_Mutation_p.R1125C	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1301	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Ig-like C2-type 8.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TGCTCCTGGCGCGCGGCCAGG	0.627		NA											51	171					0	0	0	0
MECOM	2122	broad.mit.edu	37	3	168834351	168834351	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:168834351C>A	uc003ffi.3	-	7	1014	c.745G>T	c.(745-747)GGA>TGA	p.G249*	MECOM_uc010hwk.1_Nonsense_Mutation_p.G272*|MECOM_uc003ffj.3_Nonsense_Mutation_p.G314*|MECOM_uc011bpi.1_Nonsense_Mutation_p.G250*|MECOM_uc003ffn.3_Nonsense_Mutation_p.G249*|MECOM_uc003ffk.2_Nonsense_Mutation_p.G249*|MECOM_uc003ffl.2_Nonsense_Mutation_p.G409*|MECOM_uc011bpj.1_Nonsense_Mutation_p.G437*|MECOM_uc011bpk.1_Nonsense_Mutation_p.G239*|MECOM_uc010hwn.2_Nonsense_Mutation_p.G437*	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	249	Interaction with MAPK9, SMAD3 and probably SUV39H1.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CCAAAAAATCCACCTGCCGCA	0.453		NA											18	59					1.26e-06	1.78e-06	1	0
MYNN	55892	broad.mit.edu	37	3	169496734	169496734	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr3:169496734G>C	uc003fft.2	+	3	874	c.445G>C	c.(445-447)GAT>CAT	p.D149H	MYNN_uc011bpm.1_Missense_Mutation_p.D35H|MYNN_uc003ffu.2_Missense_Mutation_p.D149H|MYNN_uc003ffv.2_5'UTR|MYNN_uc010hwo.2_Missense_Mutation_p.D149H|MYNN_uc003ffw.1_RNA	NM_018657	NP_061127	Q9NPC7	MYNN_HUMAN	myoneurin	149						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			TACTCTGCGAGATTATAATAA	0.343		NA											21	36					0	0	0	0
SRD5A3	79644	broad.mit.edu	37	4	56230347	56230347	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr4:56230347G>C	uc003hau.2	+	3	566	c.471G>C	c.(469-471)ATG>ATC	p.M157I	uc003hav.1_RNA	NM_024592	NP_078868	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	157	Lumenal (Potential).				androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			CCAATGTCATGATTCACGTCG	0.483		NA											16	72					0	0	0	0
MAP1B	4131	broad.mit.edu	37	5	71491499	71491499	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:71491499G>A	uc003kbw.3	+	5	2558	c.2317G>A	c.(2317-2319)GCC>ACC	p.A773T	MAP1B_uc010iyw.1_Missense_Mutation_p.A790T|MAP1B_uc010iyx.1_Missense_Mutation_p.A647T|MAP1B_uc010iyy.1_Missense_Mutation_p.A647T	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	773	Lys-rich (highly basic, contains many KKEE and KKEI/V repeats).					microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TTCTGTTGCTGCCGGAAAGCC	0.473		NA											37	124					0	0	0	0
VCAN	1462	broad.mit.edu	37	5	82808041	82808041	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:82808041G>A	uc003kii.3	+	6	1224	c.868G>A	c.(868-870)GGC>AGC	p.G290S	VCAN_uc003kij.3_Missense_Mutation_p.G290S|VCAN_uc010jau.2_Missense_Mutation_p.G290S|VCAN_uc003kik.3_Missense_Mutation_p.G290S|VCAN_uc003kih.3_Missense_Mutation_p.G290S	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	290	Link 2.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ATGGAGGAACGGCTTTGACCA	0.602		NA											15	26					0	0	0	0
SEC24A	10802	broad.mit.edu	37	5	134007526	134007526	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:134007526C>G	uc003kzs.2	+	4	1055	c.767C>G	c.(766-768)TCT>TGT	p.S256C	SEC24A_uc011cxu.1_Missense_Mutation_p.L24V	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	256					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AATAACGGATCTATGGTGGTC	0.308		NA											12	27					0	0	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203521	140203521	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:140203521C>T	uc003lhl.2	+	1	2161	c.2161C>T	c.(2161-2163)CGG>TGG	p.R721W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.R721W|PCDHA5_uc003lhj.1_Missense_Mutation_p.R721W	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	721	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCGCGCTGCGGTGCTCGGC	0.667		NA											33	69					0	0	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735144	140735144	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:140735144T>C	uc003ljq.1	+	1	377	c.377T>C	c.(376-378)GTT>GCT	p.V126A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.V126A	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	126	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAATCGATGTTAATGATAAC	0.423		NA											19	36					0	0	0	0
TCOF1	6949	broad.mit.edu	37	5	149754239	149754239	+	Silent	SNP	C	C	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr5:149754239C>A	uc003lry.2	+	9	1251	c.1143C>A	c.(1141-1143)TCC>TCA	p.S381S	TCOF1_uc003lrw.2_Silent_p.S381S|TCOF1_uc011dch.1_Silent_p.S381S|TCOF1_uc003lrz.2_Silent_p.S381S|TCOF1_uc003lrx.2_Silent_p.S304S|TCOF1_uc003lsa.2_Silent_p.S304S|TCOF1_uc011dci.1_5'Flank	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	381					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAAGGAGTCCCCCAGGAAAG	0.657		NA											20	66					1.26e-06	1.78e-06	1	0
MYLK4	340156	broad.mit.edu	37	6	2675332	2675332	+	Silent	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:2675332G>C	uc003mty.3	-	11	1365	c.1068C>G	c.(1066-1068)CTC>CTG	p.L356L	MYLK4_uc003mtx.3_Silent_p.L71L	NM_001012418	NP_001012418	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	356	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(3)|ovary(1)	4	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				AGGGGTGCTTGAGAGCTTCGC	0.488		NA											25	66					0	0	0	0
ZNF184	7738	broad.mit.edu	37	6	27420303	27420303	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:27420303C>G	uc003njj.2	-	5	1846	c.1035G>C	c.(1033-1035)CAG>CAC	p.Q345H	ZNF184_uc010jqv.2_Missense_Mutation_p.Q345H|ZNF184_uc003nji.2_Missense_Mutation_p.Q345H	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	345	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGTGGCCTCTCTGGCTAAAGG	0.423		NA											6	30					0	0	0	0
HLA-A	3105	broad.mit.edu	37	6	29910349	29910349	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:29910349C>T	uc003nol.2	+	1	19	c.19C>T	c.(19-21)CGA>TGA	p.R7*	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Nonsense_Mutation_p.R7*|HLA-A_uc003noo.2_Nonsense_Mutation_p.R7*|HLA-A_uc010jrr.2_Nonsense_Mutation_p.R7*|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_5'Flank|HLA-A_uc011dmc.1_5'Flank|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	7					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CATGGCGCCCCGAACCCTCCT	0.677		NA							Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			17	65					0	0	0	0
VPS52	6293	broad.mit.edu	37	6	33219368	33219368	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:33219368G>A	uc003odm.1	-	19	2162	c.1952C>T	c.(1951-1953)TCA>TTA	p.S651L	VPS52_uc003odn.1_Missense_Mutation_p.S462L	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	651					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						TTCCACTGATGATTTCCAGGA	0.507		NA											30	74					0	0	0	0
LRFN2	57497	broad.mit.edu	37	6	40359913	40359913	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:40359913C>T	uc003oph.1	-	3	2604	c.2139G>A	c.(2137-2139)CCG>CCA	p.P713P		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	713	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGCCCTCCAACGGCAAGGGGA	0.736		NA											5	14					0	0	0	0
NCR2	9436	broad.mit.edu	37	6	41318601	41318601	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:41318601G>A	uc003oqh.2	+	5	917	c.830G>A	c.(829-831)TGA>TAA	p.*277*	NCR2_uc003oqi.2_3'UTR|NCR2_uc003oqj.2_3'UTR	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	277					cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					cacactttgtgaataataaaa	0.169		NA											15	39					0	0	0	0
MAN1A1	4121	broad.mit.edu	37	6	119501047	119501047	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:119501047G>A	uc003pym.1	-	13	2341	c.1899C>T	c.(1897-1899)AGC>AGT	p.S633S		NM_005907	NP_005898	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	633	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		GATGTGCCTCGCTATTGAAGA	0.378		NA											9	39					0	0	0	0
NCOA7	135112	broad.mit.edu	37	6	126203622	126203622	+	Silent	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:126203622G>A	uc010kes.2	+	9	1073	c.624G>A	c.(622-624)TCG>TCA	p.S208S	NCOA7_uc003qae.3_Silent_p.S208S|NCOA7_uc003qah.2_Silent_p.S208S|NCOA7_uc003qai.2_Silent_p.S208S|NCOA7_uc010ket.2_Silent_p.S104S|NCOA7_uc003qaf.2_Silent_p.S208S|NCOA7_uc003qag.2_Silent_p.S208S	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	208					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		GAGTCTTATCGTCTACTTCTG	0.348		NA											7	39					0	0	0	0
NCOA7	135112	broad.mit.edu	37	6	126210917	126210917	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:126210917G>A	uc010kes.2	+	11	2166	c.1717G>A	c.(1717-1719)GAG>AAG	p.E573K	NCOA7_uc003qae.3_Missense_Mutation_p.E573K|NCOA7_uc003qah.2_Missense_Mutation_p.E562K|NCOA7_uc003qai.2_Missense_Mutation_p.E573K|NCOA7_uc010ket.2_Missense_Mutation_p.E458K	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	573					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		TCCCATAACTGAGGGCAATAA	0.438		NA											13	43					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152706952	152706952	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:152706952C>T	uc010kiw.2	-	55	9111	c.8509G>A	c.(8509-8511)GAG>AAG	p.E2837K	SYNE1_uc003qot.3_Missense_Mutation_p.E2844K|SYNE1_uc003qou.3_Missense_Mutation_p.E2837K|SYNE1_uc010kjb.1_Missense_Mutation_p.E2820K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2837	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCACAATCTCTTCCACTTTC	0.408		NA								HNSCC(10;0.0054)			19	79					0	0	0	0
QKI	9444	broad.mit.edu	37	6	163876442	163876442	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr6:163876442G>C	uc003qui.2	+	2	825	c.274G>C	c.(274-276)GAA>CAA	p.E92Q	QKI_uc003que.2_Missense_Mutation_p.E92Q|QKI_uc003quf.2_Missense_Mutation_p.E92Q|QKI_uc003qug.2_Missense_Mutation_p.E92Q|QKI_uc003quh.2_Missense_Mutation_p.E92Q|QKI_uc003quj.2_Missense_Mutation_p.E92Q	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	92	KH.				mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		GCCTGTAAAAGAATACCCAGA	0.343		NA											24	54					0	0	0	0
DGKB	1607	broad.mit.edu	37	7	14378224	14378224	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:14378224G>A	uc003ssz.2	-	22	2228	c.2041C>T	c.(2041-2043)CGA>TGA	p.R681*	DGKB_uc011jxt.1_Nonsense_Mutation_p.R662*|DGKB_uc003sta.2_Nonsense_Mutation_p.R681*|DGKB_uc011jxu.1_Nonsense_Mutation_p.R680*	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	681					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	CGATGGCTTCGTCTTTTCTTA	0.398		NA											30	68					0	0	0	0
GRM3	2913	broad.mit.edu	37	7	86468769	86468769	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:86468769G>A	uc003uid.2	+	4	3038	c.1939G>A	c.(1939-1941)GGG>AGG	p.G647R	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Missense_Mutation_p.G519R|GRM3_uc010leh.2_Missense_Mutation_p.G239R	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	647	Helical; Name=3; (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GCGCCGACTCGGGCTGGGGAG	0.527		NA											53	136					0	0	0	0
ZNF789	285989	broad.mit.edu	37	7	99084583	99084583	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:99084583T>G	uc003uqq.1	+	5	969	c.750T>G	c.(748-750)TGT>TGG	p.C250W	ZNF789_uc010lfw.1_Missense_Mutation_p.C155W|ZNF789_uc003uqr.1_Missense_Mutation_p.C192W	NM_213603	NP_998768	Q5FWF6	ZN789_HUMAN	zinc finger protein 789 isoform 1	250	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					ATAAACAGTGTCACCTGCAAA	0.428		NA											27	67					0	0	0	0
WASL	8976	broad.mit.edu	37	7	123346798	123346798	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:123346798C>T	uc003vkz.2	-	3	663	c.335G>A	c.(334-336)GGA>GAA	p.G112E		NM_003941	NP_003932	O00401	WASL_HUMAN	Wiskott-Aldrich syndrome gene-like protein	112	WH1.				actin polymerization or depolymerization|axon guidance|cellular component movement|nitric oxide metabolic process|protein complex assembly|regulation of nitric-oxide synthase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|cytosol|nucleolus|plasma membrane	actin binding|small GTPase regulator activity				0						ACTTACATCTCCAGCAAAGGT	0.284		NA											18	38					0	0	0	0
TMEM140	55281	broad.mit.edu	37	7	134849458	134849458	+	Missense_Mutation	SNP	G	G	A	rs143180494	by1000genomes	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr7:134849458G>A	uc003vsi.2	+	2	546	c.265G>A	c.(265-267)GGG>AGG	p.G89R	C7orf49_uc003vsh.2_Intron	NM_018295	NP_060765	Q9NV12	TM140_HUMAN	transmembrane protein 140	89	Helical; (Potential).					integral to membrane				large_intestine(1)	1						TGGCGTGTACGGGTCCCTGGT	0.652		NA											38	69					0	0	0	0
TAF2	6873	broad.mit.edu	37	8	120818639	120818639	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr8:120818639C>T	uc003you.2	-	4	572	c.302G>A	c.(301-303)AGA>AAA	p.R101K		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	101					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ATTGAGGTTTCTCCTGGGGAA	0.313		NA											18	64					0	0	0	0
ZC3H3	23144	broad.mit.edu	37	8	144557590	144557590	+	Silent	SNP	G	G	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr8:144557590G>T	uc003yyd.2	-	5	1910	c.1881C>A	c.(1879-1881)GGC>GGA	p.G627G		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	627					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			GGGGCCTGCTGCCCGCATCAC	0.657		NA											13	37					4.37e-10	6.3e-10	1	0
TAF1L	138474	broad.mit.edu	37	9	32635389	32635389	+	Silent	SNP	C	C	T	rs55895024	byFrequency	TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:32635389C>T	uc003zrg.1	-	1	279	c.189G>A	c.(187-189)AAG>AAA	p.K63K	uc003zrh.1_Intron	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	63					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CTGCCAAGTGCTTCTTACACT	0.547		NA											35	134					0	0	0	0
UBE2R2	54926	broad.mit.edu	37	9	33917126	33917126	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:33917126C>G	uc003ztm.2	+	5	1182	c.608C>G	c.(607-609)TCA>TGA	p.S203*		NM_017811	NP_060281	Q712K3	UB2R2_HUMAN	ubiquitin-conjugating enzyme UBC3B	203	Asp/Glu-rich (acidic).				protein K48-linked ubiquitination|protein monoubiquitination		ATP binding|ubiquitin-protein ligase activity				0			LUSC - Lung squamous cell carcinoma(29;0.0176)	GBM - Glioblastoma multiforme(74;0.188)		GACAACAGCTCAGATTTGCTT	0.328		NA											8	66					0	0	0	0
ARID3C	138715	broad.mit.edu	37	9	34623560	34623560	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:34623560G>A	uc011lon.1	-	4	727	c.727C>T	c.(727-729)CGG>TGG	p.R243W		NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)	243	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		TGAGCGCCCCGAGGGGGCGGC	0.746		NA											7	42					0	0	0	0
TLN1	7094	broad.mit.edu	37	9	35715166	35715166	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:35715166C>T	uc003zxt.2	-	21	2998	c.2644G>A	c.(2644-2646)GAC>AAC	p.D882N		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	882					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TCCTCACTGTCAGGGTGGGCA	0.592		NA											10	93					0	0	0	0
C9orf135	138255	broad.mit.edu	37	9	72471558	72471558	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:72471558G>A	uc004ahl.2	+	3	414	c.349G>A	c.(349-351)GAG>AAG	p.E117K	C9orf135_uc011lrw.1_Missense_Mutation_p.E9K|C9orf135_uc010moq.2_Missense_Mutation_p.E9K|C9orf135_uc011lrx.1_RNA|C9orf135_uc010mop.2_Missense_Mutation_p.E117K	NM_001010940	NP_001010940	Q5VTT2	CI135_HUMAN	hypothetical protein LOC138255	117	Extracellular (Potential).					integral to membrane				ovary(1)	1						TTTATTGAATGAGGAAACAGT	0.348		NA											8	69					0	0	0	0
IARS	3376	broad.mit.edu	37	9	95043130	95043130	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:95043130C>G	uc004art.1	-	7	900	c.643G>C	c.(643-645)GAT>CAT	p.D215H	IARS_uc004ars.1_Missense_Mutation_p.D60H|IARS_uc004aru.3_Missense_Mutation_p.D215H|IARS_uc010mqr.2_Missense_Mutation_p.D105H|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	215					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	ACAGTTTCATCTTCTTCCAAA	0.353		NA											4	52					0	0	0	0
C5	727	broad.mit.edu	37	9	123731393	123731393	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:123731393G>C	uc004bkv.2	-	33	4196	c.4166C>G	c.(4165-4167)TCC>TGC	p.S1389C		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	1389					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TCTGTAGTGGGATGCTGGCAC	0.413		NA											15	106					0	0	0	0
TTLL11	158135	broad.mit.edu	37	9	124751422	124751422	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:124751422T>A	uc004blt.1	-	4	1779	c.1591A>T	c.(1591-1593)AGG>TGG	p.R531W	TTLL11_uc011lyl.1_Intron|TTLL11_uc004blr.2_Intron|TTLL11_uc011lym.1_Intron|TTLL11_uc004blu.1_3'UTR	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	531	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						CAGAGAGCCCTCTTGAGGCCG	0.547		NA											29	113					0	0	0	0
LRSAM1	90678	broad.mit.edu	37	9	130257620	130257620	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:130257620G>A	uc004brb.1	+	22	1966	c.1621G>A	c.(1621-1623)GAA>AAA	p.E541K	LRSAM1_uc010mxk.1_Missense_Mutation_p.E514K|LRSAM1_uc004brc.1_Missense_Mutation_p.E541K|LRSAM1_uc004brd.1_Missense_Mutation_p.E541K|LRSAM1_uc004bre.1_Missense_Mutation_p.E121K|uc004brf.1_5'Flank|LRSAM1_uc004brg.1_5'UTR	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	541	Potential.				negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						AGCCAAAAGTGAAACCAGGCA	0.418		NA											8	46					0	0	0	0
AK1	203	broad.mit.edu	37	9	130630646	130630646	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:130630646G>A	uc004bsm.3	-	6	623	c.470C>T	c.(469-471)ACA>ATA	p.T157I		NM_000476	NP_000467	P00568	KAD1_HUMAN	adenylate kinase 1	157					ATP metabolic process|nucleobase, nucleoside and nucleotide interconversion	cytosol	adenylate kinase activity|ATP binding|protein binding				0						GACAGGTTCTGTGGCCTTGTA	0.532		NA											10	17					0	0	0	0
BAT2L1	84726	broad.mit.edu	37	9	134321939	134321939	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:134321939C>T	uc004can.3	+	6	820	c.765C>T	c.(763-765)CTC>CTT	p.L255L	BAT2L1_uc010mzj.1_5'Flank|BAT2L1_uc004cam.1_Silent_p.L255L	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	255							protein binding				0						ACCCCTCTCTCCGCCCGGCTC	0.562		NA											5	48					0	0	0	0
FAM69B	138311	broad.mit.edu	37	9	139617956	139617956	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr9:139617956C>T	uc004cik.2	+	5	1120	c.1026C>T	c.(1024-1026)TAC>TAT	p.Y342Y	FAM69B_uc004cil.2_Silent_p.Y255Y|SNHG7_uc004cim.2_Intron	NM_152421	NP_689634	Q5VUD6	FA69B_HUMAN	hypothetical protein LOC138311	342	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;1.03e-05)|Epithelial(140;0.00013)		ACTGCACCTACGGGCGCGACT	0.687		NA											8	13					0	0	0	0
SYAP1	94056	broad.mit.edu	37	X	16737953	16737953	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chrX:16737953G>C	uc004cxp.2	+	1	199	c.106G>C	c.(106-108)GAG>CAG	p.E36Q	SYAP1_uc004cxo.2_Missense_Mutation_p.E36Q|SYAP1_uc011miv.1_Silent_p.L14L	NM_032796	NP_116185	Q96A49	SYAP1_HUMAN	SYAP1 protein	36										skin(1)	1	Hepatocellular(33;0.0997)					GACGGTGGCTGAGTCTGCGGA	0.667		NA											4	3					0	0	0	0
SSX1	6756	broad.mit.edu	37	X	48123288	48123288	+	Silent	SNP	C	C	T			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chrX:48123288C>T	uc004djb.1	+	6	493	c.402C>T	c.(400-402)AAC>AAT	p.N134N		NM_005635	NP_005626	Q16384	SSX1_HUMAN	synovial sarcoma, X breakpoint 1	134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|transcription corepressor activity		SS18/SSX1(1169)	soft_tissue(1169)	1169						GCCCACAAAACGATGGGAAAC	0.423		NA											82	59					0	0	0	0
MBD6	114785	broad.mit.edu	37	12	57920934	57920934	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr12:57920934delC	uc001soj.1	+	7	2230	c.2006delC	c.(2005-2007)GCCfs	p.A669fs	MBD6_uc001sok.1_Frame_Shift_Del_p.A536fs|MBD6_uc001sol.1_RNA	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	669	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CCACTTTCAGCCCCCCCTACC	0.642		NA											14	29	---	---	---	---	NA	NA	NA	NA
SREBF1	6720	broad.mit.edu	37	17	17720296	17720297	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:17720296_17720297insTT	uc002gru.1	-	9	1954_1955	c.1760_1761insAA	c.(1759-1761)AAGfs	p.K587fs	SREBF1_uc002grp.1_Frame_Shift_Ins_p.K206fs|SREBF1_uc002grq.1_Frame_Shift_Ins_p.K106fs|SREBF1_uc002grr.1_Frame_Shift_Ins_p.K333fs|SREBF1_uc002grs.1_Frame_Shift_Ins_p.K563fs|SREBF1_uc002grt.1_Frame_Shift_Ins_p.K617fs	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	587	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						GGTCAGCCTGCTTGCGATGCCT	0.653		NA											37	100	---	---	---	---	NA	NA	NA	NA
RSAD1	55316	broad.mit.edu	37	17	48556334	48556334	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr17:48556334delC	uc002iqw.1	+	1	145	c.89delC	c.(88-90)TCCfs	p.S30fs	RSAD1_uc010wmp.1_Frame_Shift_Del_p.S30fs|RSAD1_uc010wmq.1_RNA	NM_018346	NP_060816	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing	30					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GCAGGAGGGTCCCCGAGTCCT	0.776		NA									OREG0024566	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---	NA	NA	NA	NA
ZNF831	128611	broad.mit.edu	37	20	57768086	57768086	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CR-7373-01A-11D-2012-08	TCGA-CR-7373-10A-01D-2013-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9b1f5f6d-503c-4933-944a-b4fd1cc3fa93	88363097-f88e-49cc-9f95-068aa5a3a03f	g.chr20:57768086delT	uc002yan.2	+	1	2012	c.2012delT	c.(2011-2013)GTCfs	p.V671fs		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	671						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TCAGGCACAGTCCCCACCCAA	0.622		NA											19	35	---	---	---	---	NA	NA	NA	NA
