Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ATRX	546	broad.mit.edu	37	X	76875970	76875970	+	Missense_Mutation	SNP	T	T	C			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chrX:76875970T>C	ENST00000373344.5	-	20	5379	c.5165A>G	c.(5164-5166)cAt>cGt	p.H1722R	ATRX_ENST00000395603.3_Missense_Mutation_p.H1684R|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.3	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1722	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TTTTAGAATATGGCCTTCATC	0.294000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						4	7					0	0	1	0	0
AGAP3	116988	broad.mit.edu	37	7	150815375	150815375	+	Missense_Mutation	SNP	C	C	A			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr7:150815375C>A	ENST00000397238.2	+	6	785	c.785C>A	c.(784-786)aCc>aAc	p.T262N	AGAP3_ENST00000335367.3_Missense_Mutation_p.T442N|AGAP3_ENST00000463381.1_Missense_Mutation_p.T34N|AGAP3_ENST00000479901.1_Missense_Mutation_p.T262N|AGAP3_ENST00000473312.1_Missense_Mutation_p.T262N|AGAP3_ENST00000476375.1_3'UTR	NM_031946.4	NP_114152.3	Q96P47	AGAP3_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	226	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						AAGCGGTGCACCTACTATGAG	0.642000													33	94					4.34311e-12	5.24168e-12	1	1	0
CLCNKA	1187	broad.mit.edu	37	1	16359720	16359720	+	Missense_Mutation	SNP	G	G	A			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr1:16359720G>A	ENST00000375692.1	+	20	2110	c.1982G>A	c.(1981-1983)gGc>gAc	p.G661D	CLCNKA_ENST00000331433.4_Missense_Mutation_p.G662D|CLCNKA_ENST00000420078.1_Missense_Mutation_p.G661D|CLCNKA_ENST00000464764.1_3'UTR|CLCNKA_ENST00000439316.2_Missense_Mutation_p.G619D			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	662	CBS 2.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity	p.G662V(1)		breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	ACATCGCGGGGCAGAGCTGTG	0.607000											OREG0013132	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	231					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44853776	44853776	+	Missense_Mutation	SNP	C	C	A			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr3:44853776C>A	ENST00000326047.4	+	18	2421	c.2272C>A	c.(2272-2274)Cag>Aag	p.Q758K	KIF15_ENST00000425755.1_Missense_Mutation_p.Q393K	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	758					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		TACCCAAATGCAGGAGGTGAG	0.423000													3	39					1	1	1	1	0
PSMG1	8624	broad.mit.edu	37	21	40552362	40552362	+	Splice_Site	SNP	G	G	C			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr21:40552362G>C	ENST00000331573.3	-	3	707	c.242C>G	c.(241-243)gCa>gGa	p.A81G	PSMG1_ENST00000380900.2_Splice_Site_p.A81G	NM_001261824.1|NM_003720.3	NP_001248753.1|NP_003711.1	O95456	PSMG1_HUMAN	proteasome (prosome, macropain) assembly chaperone 1	81					proteasome assembly	endoplasmic reticulum	protein binding			autonomic_ganglia(1)|endometrium(2)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(2)	8		Prostate(19;8.44e-08)				TGACAGAAATGCTGTAAAAAA	0.358000													20	57					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52704261	52704261	+	Missense_Mutation	SNP	A	A	G			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr1:52704261A>G	ENST00000287727.3	+	4	1344	c.1172A>G	c.(1171-1173)gAg>gGg	p.E391G	ZFYVE9_ENST00000371591.1_Missense_Mutation_p.E391G|ZFYVE9_ENST00000357206.2_Missense_Mutation_p.E391G			O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	391					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						AATATGACAGAGCATTTCTCT	0.363000													15	83					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946434	16946434	+	RNA	SNP	C	C	T	rs367060		TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr1:16946434C>T	ENST00000412962.1	-	0	1085																											CTCAGCCTTCCGCCGGGCCAG	0.672000													3	10					0	0	1	0	0
C7orf63	79846	broad.mit.edu	37	7	89874847	89874847	+	Missense_Mutation	SNP	G	G	T			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr7:89874847G>T	ENST00000389297.4	+	1	360	c.109G>T	c.(109-111)Gat>Tat	p.D37Y	C7orf63_ENST00000497910.1_Missense_Mutation_p.D37Y|C7orf63_ENST00000463311.1_3'UTR|C7orf63_ENST00000316089.8_Missense_Mutation_p.D37Y	NM_001039706.2|NM_001160138.1	NP_001034795.2|NP_001153610.1	A5D8W1	CG063_HUMAN	chromosome 7 open reading frame 63	37							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						GACGGAGGACGATGAGGCGCA	0.627000													4	173					0.00116845	0.00131921	1	1	0
OR5M10	390167	broad.mit.edu	37	11	56344882	56344882	+	Missense_Mutation	SNP	C	C	T			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr11:56344882C>T	ENST00000526812.2	-	1	381	c.316G>A	c.(316-318)Gcc>Acc	p.A106T		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						ATCACTAGGGCGATGAAGAGA	0.438000													14	61					0	0	1	0	0
LRRC8C	84230	broad.mit.edu	37	1	90178874	90178874	+	Missense_Mutation	SNP	A	A	G			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr1:90178874A>G	ENST00000370454.4	+	3	1000	c.745A>G	c.(745-747)Agg>Ggg	p.R249G	LRRC8C_ENST00000479252.1_Intron|RP11-302M6.4_ENST00000370453.5_Intron	NM_032270.4	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member C	249						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	28		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		GAAGAAGTTCAGGCTGCATGT	0.403000													4	96					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101797192	101797192	+	Missense_Mutation	SNP	C	C	T			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr13:101797192C>T	ENST00000251127.6	-	16	1976	c.1895G>A	c.(1894-1896)cGa>cAa	p.R632Q		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	632						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTCAAAGATTCGCAGGCGTAA	0.348000													89	187					0	0	1	0	0
TRPM7	54822	broad.mit.edu	37	15	50886773	50886773	+	Missense_Mutation	SNP	C	C	T			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr15:50886773C>T	ENST00000313478.7	-	24	3609	c.3328G>A	c.(3328-3330)Gta>Ata	p.V1110I	TRPM7_ENST00000560955.1_Missense_Mutation_p.V1110I	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	1110					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TACTTCCATACAATATTGGAA	0.299000													14	19					0	0	1	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76074431	76074431	+	RNA	SNP	C	C	T	rs149323153	by1000genomes	TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr15:76074431C>T	ENST00000395215.3	+	0	610																		p.S190L(2)									CTCCAGTCCTCGAGCTGCAGA	0.547000													4	32					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								28	49					0	0	1	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530285	80530285	+	Missense_Mutation	SNP	G	G	C			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr2:80530285G>C	ENST00000295057.3	-	2	1316	c.660C>G	c.(658-660)gaC>gaG	p.D220E	CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000402739.4_Intron|CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000541047.1_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.D220E|CTNNA2_ENST00000540488.1_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	220						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						CCTTGACCAAGTCGTTGTGCT	0.572000										HNSCC(69;0.2)			11	124					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207171520	207171520	+	Silent	SNP	G	G	A			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr2:207171520G>A	ENST00000374423.3	+	5	2654	c.2268G>A	c.(2266-2268)ccG>ccA	p.P756P		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	756							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						ATTCTGACCCGCCTCTTCTGT	0.418000													4	197					0	0	1	0	0
FADS3	3995	broad.mit.edu	37	11	61644404	61644404	+	Missense_Mutation	SNP	C	C	T			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr11:61644404C>T	ENST00000540820.1	-	8	989	c.917G>A	c.(916-918)cGc>cAc	p.R306H	FADS3_ENST00000527697.1_Missense_Mutation_p.R182H|FADS3_ENST00000525588.1_Missense_Mutation_p.R278H|FADS3_ENST00000278829.2_Missense_Mutation_p.R306H			Q9Y5Q0	FADS3_HUMAN	fatty acid desaturase 3	306					electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	heme binding|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						TAAGAAGAAGCGGGCATAGAA	0.622000													3	5					0	0	1	0	0
ITFG3	83986	broad.mit.edu	37	16	312148	312148	+	Silent	SNP	C	C	T			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr16:312148C>T	ENST00000399932.3	+	7	1216	c.765C>T	c.(763-765)agC>agT	p.S255S	ITFG3_ENST00000450082.2_Silent_p.S255S|ITFG3_ENST00000600536.1_Silent_p.S255S|ITFG3_ENST00000301678.3_Silent_p.S255S|ITFG3_ENST00000442458.2_Silent_p.S255S|ITFG3_ENST00000301679.2_Silent_p.S255S	NM_001284497.1	NP_001271426.1	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	255						integral to membrane				central_nervous_system(3)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				TCAGAGGCAGCCTTGGTGTGG	0.587000													17	33					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55541829	55541829	+	Missense_Mutation	SNP	C	C	T			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr8:55541829C>T	ENST00000220676.1	+	4	5535	c.5387C>T	c.(5386-5388)aCg>aTg	p.T1796M		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1796					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding	p.T1796M(1)		NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CCAGGCCCAACGATGGATGAA	0.448000													8	12					0	0	1	0	0
NEURL1	9148	broad.mit.edu	37	10	105331484	105331484	+	Missense_Mutation	SNP	C	C	T			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr10:105331484C>T	ENST00000369780.4	+	3	963	c.554C>T	c.(553-555)tCg>tTg	p.S185L	NEURL_ENST00000465048.1_3'UTR|NEURL_ENST00000369777.2_Missense_Mutation_p.S168L	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		185	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		ATCAACGACTCGGCTGTTATG	0.632000													11	51					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55598323	55598323	+	Silent	SNP	C	C	A			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr1:55598323C>A	ENST00000294383.6	-	31	3431	c.3432G>T	c.(3430-3432)ctG>ctT	p.L1144L	USP24_ENST00000407756.1_Silent_p.L984L	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1144	Ser-rich.				ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						GCTTTGATGACAGGGATGGAG	0.393000													3	40					0.004672	0.00511	1	1	0
PAG1	55824	broad.mit.edu	37	8	81897059	81897059	+	Silent	SNP	C	C	T			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr8:81897059C>T	ENST00000220597.4	-	7	1538	c.828G>A	c.(826-828)ggG>ggA	p.G276G		NM_018440.3	NP_060910.3	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid microdomains 1	276					epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|prostate(2)	11	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			CCGCCTCTCCCCCTTCCTTCT	0.502000													5	107					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179470238	179470238	+	Missense_Mutation	SNP	A	A	T			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr2:179470238A>T	ENST00000589042.1	-	279	54008	c.53784T>A	c.(53782-53784)gaT>gaA	p.D17928E	TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D9055E|TTN_ENST00000591111.1_Missense_Mutation_p.D16287E|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D8988E|TTN_ENST00000460472.2_Missense_Mutation_p.D8863E|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D15360E|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16287	Fibronectin type-III 29.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGTGTTCATCAAGATTTT	0.393000													17	114					0	0	1	0	0
LINC00971	440970	broad.mit.edu	37	3	84741480	84741480	+	RNA	DEL	A	A	-	rs140144338		TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr3:84741480delA	ENST00000484892.1	-	0	2354					NR_033860.1																						CCTGTCCCAGAAAAAAAAAAA	0.388													3	6	---	---	---	---					
TBC1D1	23216	broad.mit.edu	37	4	38020014	38020014	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr4:38020014delA	ENST00000261439.4	+	4	1277	c.922delA	c.(922-924)aaafs	p.K309fs	TBC1D1_ENST00000508802.1_Frame_Shift_Del_p.K309fs	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	309	PID.					nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						TCCTGACACCAAAAAAATAGC	0.313													7	122	---	---	---	---					
PPARGC1B	133522	broad.mit.edu	37	5	149216400	149216402	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr5:149216400_149216402delCAG	ENST00000309241.5	+	8	2414_2416	c.2382_2384delCAG	c.(2380-2385)gacagc>gac	p.S799del	PPARGC1B_ENST00000403750.1_In_Frame_Del_p.S735del|PPARGC1B_ENST00000394320.3_In_Frame_Del_p.S799del|PPARGC1B_ENST00000360453.4_In_Frame_Del_p.S760del	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	799	Glu-rich.				estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity	p.S795N(1)		NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TCTTTGAAGACAGCAGCAGCAGC	0.601													9	195	---	---	---	---					
PEX1	5189	broad.mit.edu	37	7	92146721	92146721	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr7:92146721delT	ENST00000248633.4	-	5	1203	c.1108delA	c.(1108-1110)attfs	p.I370fs	PEX1_ENST00000541751.1_5'UTR|PEX1_ENST00000438045.1_Intron|PEX1_ENST00000428214.1_Frame_Shift_Del_p.I370fs	NM_000466.2	NP_000457.1	O43933	PEX1_HUMAN	peroxisomal biogenesis factor 1	370					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TCTGACCTAATTTTTTTTTGA	0.353													12	284	---	---	---	---					
PKHD1L1	93035	broad.mit.edu	37	8	110455173	110455174	+	Splice_Site	INS	-	-	G			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr8:110455173_110455174insG	ENST00000378402.5	+	36	4497		c.e36-1			NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1						immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTTTATGGCAGGTTCATTTTC	0.322										HNSCC(38;0.096)			7	133	---	---	---	---					
KTN1-AS1	100129075	broad.mit.edu	37	14	56014173	56014174	+	RNA	DEL	AG	AG	-	rs72015246		TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr14:56014173_56014174delAG	ENST00000554558.1	-	0	364																											aaaaaaaaaaagaaTTGGCACA	0.446													5	9	---	---	---	---					
TCF12	6938	broad.mit.edu	37	15	57523450	57523451	+	Frame_Shift_Ins	INS	-	-	GCAA			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr15:57523450_57523451insGCAA	ENST00000267811.5	+	9	984_985	c.680_681insGCAA	c.(679-684)atgcaafs	p.-228fs	TCF12_ENST00000438423.2_Frame_Shift_Ins_p.-228fs|TCF12_ENST00000452095.2_Frame_Shift_Ins_p.-224fs|TCF12_ENST00000333725.5_Frame_Shift_Ins_p.-228fs|TCF12_ENST00000557843.1_Frame_Shift_Ins_p.-228fs|TCF12_ENST00000543579.1_Frame_Shift_Ins_p.-58fs|TCF12_ENST00000537840.1_Frame_Shift_Ins_p.-39fs|TCF12_ENST00000560764.1_3'UTR|TCF12_ENST00000343827.3_Frame_Shift_Ins_p.-58fs	NM_003205.3|NM_207038.1	NP_003196.1|NP_996921.1	Q99081	HTF4_HUMAN	transcription factor 12						immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity		TCF12/NR4A3(2)	breast(2)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	36		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		ACTTTCTTTATGCAAGGTAAGT	0.386			T	TEC	extraskeletal myxoid chondrosarcoma								52	129	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7579323	7579324	+	Frame_Shift_Ins	INS	-	-	A			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chr17:7579323_7579324insA	ENST00000420246.2	-	4	495_496	c.363_364insT	c.(361-366)tctgtgfs	p.V122fs	TP53_ENST00000359597.4_Frame_Shift_Ins_p.V122fs|TP53_ENST00000455263.2_Frame_Shift_Ins_p.V122fs|TP53_ENST00000269305.4_Frame_Shift_Ins_p.V122fs|TP53_ENST00000445888.2_Frame_Shift_Ins_p.V122fs|TP53_ENST00000413465.2_Frame_Shift_Ins_p.V122fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	122	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		V -> L (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.G59fs*23(3)|p.S121fs*27(1)|p.V73fs*9(1)|p.G105_T125del21(1)|p.G112_V122delGFLHSGTAKSV(1)|p.V122fs*46(1)|p.Y107fs*44(1)|p.V122L(1)|p.P13fs*18(1)|p.S33fs*23(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGCAAGTCACAGACTTGGCTG	0.559		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			68	33	---	---	---	---					
MECP2	4204	broad.mit.edu	37	X	153363105	153363105	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DB-A75O-01A-11D-A32B-08	TCGA-DB-A75O-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e96e37-0f23-40b7-8277-527e8d8f0b76	b058749c-362f-4a5f-b0f7-4ab4ec256649	g.chrX:153363105delG	ENST00000453960.2	-	1	72	c.18delC	c.(16-18)gccfs	p.A8fs	MECP2_ENST00000407218.1_5'UTR|MECP2_ENST00000303391.6_5'UTR	NM_001110792.1	NP_001104262.1	P51608	MECP2_HUMAN	methyl CpG binding protein 2 (Rett syndrome)	0					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity			breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|prostate(2)|urinary_tract(1)	23	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCGGCgcggcggcggcggcgg	0.771													2	4	---	---	---	---					
