Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ITGAV	3685	broad.mit.edu	37	2	187503008	187503008	+	Silent	SNP	T	T	C			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr2:187503008T>C	ENST00000261023.3	+	9	1081	c.807T>C	c.(805-807)ttT>ttC	p.F269F	ITGAV_ENST00000433736.2_Silent_p.F223F|ITGAV_ENST00000374907.3_Silent_p.F233F	NM_002210.3	NP_002201	P06756	ITAV_HUMAN	integrin, alpha V	269					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		TTTCAGACTTTGTTTCAGGAG	0.333000													16	42					0	0	1	0	0
NMBR	4829	broad.mit.edu	37	6	142399907	142399907	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr6:142399907G>A	ENST00000258042.1	-	2	696	c.556C>T	c.(556-558)Cgc>Tgc	p.R186C		NM_002511.2	NP_002502.2	P28336	NMBR_HUMAN	neuromedin B receptor	186					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			breast(2)|central_nervous_system(3)|endometrium(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		CTACTGATGCGAGCCACTTCT	0.498000													5	95					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S|FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													5	102					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102292723	102292723	+	RNA	SNP	A	A	C	rs143622092	by1000genomes	TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr15:102292723A>C	ENST00000561463.1	+	0	769																											GCGTGGGAACAAGGAGACACT	0.587000													3	20					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29628245	29628245	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr20:29628245G>A	ENST00000278882.3	+	6	627	c.247G>A	c.(247-249)Gcc>Acc	p.A83T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A88T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A83T														p.A83T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTTTGTTGGCCTCAAATAG	0.353000													5	103					0	0	1	0	0
KIAA0408	9729	broad.mit.edu	37	6	127771348	127771348	+	Silent	SNP	C	C	T			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr6:127771348C>T	ENST00000483725.3	-	3	621	c.285G>A	c.(283-285)acG>acA	p.T95T	SOGA3_ENST00000368268.2_3'UTR|SOGA3_ENST00000556132.1_3'UTR|SOGA3_ENST00000481848.2_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	95							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		CTTTGTGATTCGTCCTTATAA	0.353000													52	91					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20696518	20696518	+	Missense_Mutation	SNP	T	T	A			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr16:20696518T>A	ENST00000307493.4	-	2	467	c.400A>T	c.(400-402)Aca>Tca	p.T134S	ACSM1_ENST00000219151.4_5'UTR|ACSM1_ENST00000520010.1_Missense_Mutation_p.T134S	NM_052956.2	NP_443188.2	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	134					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						CACTGACCTGTTCGCATGCAG	0.582000													3	43					0	0	1	0	0
ZNF384	171017	broad.mit.edu	37	12	6776964	6776964	+	Silent	SNP	C	C	T	rs139957806		TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr12:6776964C>T	ENST00000396795.1	-	9	1964	c.1467G>A	c.(1465-1467)ccG>ccA	p.P489P	ZNF384_ENST00000396801.3_Silent_p.P550P|ZNF384_ENST00000319770.3_Silent_p.P473P|RP4-761J14.8_ENST00000589924.1_RNA|ZNF384_ENST00000361959.3_Silent_p.P550P|ZNF384_ENST00000355772.4_Silent_p.P434P|ZNF384_ENST00000396799.2_Silent_p.P489P			Q8TF68	ZN384_HUMAN	zinc finger protein 384	550	Ala-rich.|Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	breast(3)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	18						CCGTCTTATACGGGGTCAGGT	0.617000			T	"""EWSR1, TAF15 """	ALL								4	195					0	0	1	0	0
ZDHHC24	254359	broad.mit.edu	37	11	66311297	66311297	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr11:66311297G>A	ENST00000310442.3	-	2	671	c.437C>T	c.(436-438)gCc>gTc	p.A146V	ZDHHC24_ENST00000525925.1_5'UTR|ZDHHC24_ENST00000526986.1_Missense_Mutation_p.A146V	NM_207340.1	NP_997223.1	Q6UX98	ZDH24_HUMAN	zinc finger, DHHC-type containing 24	146	Leu-rich.					integral to membrane	acyltransferase activity|zinc ion binding			endometrium(1)|large_intestine(3)|ovary(1)|prostate(1)|skin(1)	7						GACGCCGGCGGCATGAAGCAG	0.701000											OREG0021110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	32					0	0	1	0	0
LAIR2	3904	broad.mit.edu	37	19	55019288	55019288	+	Silent	SNP	A	A	C			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr19:55019288A>C	ENST00000301202.2	+	3	375	c.253A>C	c.(253-255)Aga>Cga	p.R85R	LAIR2_ENST00000351841.2_Silent_p.R85R	NM_002288.4	NP_002279.2	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like receptor 2	85	Ig-like C2-type.					extracellular region	receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)	18	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		GTCAGAGGCCAGATTCCACAT	0.498000													21	60					0	0	1	0	0
UGT1A1	54658	broad.mit.edu	37	2	234669406	234669406	+	Missense_Mutation	SNP	C	C	G			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr2:234669406C>G	ENST00000360418.3	+	1	473	c.473C>G	c.(472-474)cCc>cGc	p.P158R	UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A1_ENST00000373450.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A1_ENST00000608383.1_Missense_Mutation_p.P158R|UGT1A4_ENST00000373409.3_Intron|UGT1A8_ENST00000305208.5_Missense_Mutation_p.P158R|UGT1A1_ENST00000609767.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A1_ENST00000608381.1_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A1_ENST00000609637.1_Intron|UGT1A3_ENST00000482026.1_Intron|UGT1A9_ENST00000354728.4_Intron			P22309	UD11_HUMAN		158					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CCTTGCAGCCCCATCGTGGCC	0.557000													7	123					0	0	1	0	0
WIPF2	147179	broad.mit.edu	37	17	38420949	38420949	+	Missense_Mutation	SNP	C	C	G			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr17:38420949C>G	ENST00000323571.4	+	5	761	c.521C>G	c.(520-522)tCc>tGc	p.S174C	WIPF2_ENST00000394103.3_Intron|WIPF2_ENST00000536600.1_Intron|WIPF2_ENST00000585043.1_Missense_Mutation_p.S174C|WIPF2_ENST00000583130.1_Missense_Mutation_p.S174C|WIPF2_ENST00000494757.1_3'UTR	NM_133264.4	NP_573571.1	Q8TF74	WIPF2_HUMAN	WAS/WASL interacting protein family, member 2	174						cytoplasm|cytoskeleton	actin binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	30						AAGCACAGCTCCTCTGCCCCT	0.642000										HNSCC(43;0.11)			30	47					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100365618	100365618	+	RNA	SNP	G	G	A			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr7:100365618G>A	ENST00000542585.1	+	0	5173				ZAN_ENST00000348028.3_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ATGGCGGCCAGCTCTGTGGGC	0.602000													5	32					0	0	1	0	0
COQ6	51004	broad.mit.edu	37	14	74427895	74427895	+	Missense_Mutation	SNP	C	C	T	rs138207028		TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr14:74427895C>T	ENST00000334571.2	+	9	951	c.911C>T	c.(910-912)aCg>aTg	p.T304M	COQ6_ENST00000554920.1_Intron|COQ6_ENST00000238709.4_Missense_Mutation_p.T229M|COQ6_ENST00000394026.4_Missense_Mutation_p.T279M|ENTPD5_ENST00000557325.1_Intron	NM_182476.2	NP_872282.1	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 monooxygenase	304					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(234;0.00337)		GCTGACCACACGGACTTCATC	0.512000													6	14					0	0	1	0	0
RNF133	168433	broad.mit.edu	37	7	122338322	122338322	+	Missense_Mutation	SNP	C	C	G			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr7:122338322C>G	ENST00000340112.2	-	1	888	c.651G>C	c.(649-651)agG>agC	p.R217S	CADPS2_ENST00000412584.2_Intron|CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000313070.7_Intron|CADPS2_ENST00000449022.2_Intron	NM_139175.1	NP_631914.1	Q8WVZ7	RN133_HUMAN	ring finger protein 133	217						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21						GGTTCTGAATCCTTGCTAAAC	0.378000													53	136					0	0	1	0	0
SLC32A1	140679	broad.mit.edu	37	20	37356207	37356207	+	Missense_Mutation	SNP	C	C	G			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr20:37356207C>G	ENST00000217420.1	+	2	766	c.503C>G	c.(502-504)gCg>gGg	p.A168G		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	168					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	ATCCTCATCGCGTGCCTGTAC	0.642000													11	54					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								34	54					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37044506	37044506	+	Missense_Mutation	SNP	C	C	G			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr5:37044506C>G	ENST00000282516.8	+	35	6665	c.6166C>G	c.(6166-6168)Cca>Gca	p.P2056A	NIPBL_ENST00000448238.2_Missense_Mutation_p.P2056A	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2056					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GCTAGTTGTACCACTGATGGA	0.353000													24	39					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578534	7578534	+	Missense_Mutation	SNP	C	C	G			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr17:7578534C>G	ENST00000420246.2	-	5	528	c.396G>C	c.(394-396)aaG>aaC	p.K132N	TP53_ENST00000359597.4_Missense_Mutation_p.K132N|TP53_ENST00000455263.2_Missense_Mutation_p.K132N|TP53_ENST00000413465.2_Missense_Mutation_p.K132N|TP53_ENST00000269305.4_Missense_Mutation_p.K132N|TP53_ENST00000445888.2_Missense_Mutation_p.K132N	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	132	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		K -> E (in LFS; germline mutation and in sporadic cancers; somatic mutation).|K -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> M (in sporadic cancers; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).|K -> Q (in sporadic cancers; somatic mutation).|K -> R (in sporadic cancers; somatic mutation).|K -> T (in sporadic cancers; somatic mutation).|K -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|KM -> NL (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K132N(49)|p.0?(8)|p.Y126_K132delYSPALNK(6)|p.K39N(2)|p.N131fs*27(2)|p.V73fs*9(1)|p.S127fs*36(1)|p.A129_K132delALNK(1)|p.Y126fs*11(1)|p.K132K(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.L130_M133delLNKM(1)|p.M133fs*37(1)|p.M133fs*16(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAAAACATCTTGTTGAGGG	0.562000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	13					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37046250	37046250	+	Missense_Mutation	SNP	T	T	G			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr5:37046250T>G	ENST00000282516.8	+	38	7037	c.6538T>G	c.(6538-6540)Ttt>Gtt	p.F2180V	NIPBL_ENST00000448238.2_Missense_Mutation_p.F2180V	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2180					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			ATTGATGTATTTTACAAAACA	0.299000													11	77					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96970602	96970602	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr2:96970602G>A	ENST00000323853.5	-	2	127	c.50C>T	c.(49-51)tCg>tTg	p.S17L	SNRNP200_ENST00000349783.5_Missense_Mutation_p.S17L	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	17						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						CACAAGATTCGAGTTCTGAAA	0.488000													7	21					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22154888	22154888	+	Missense_Mutation	SNP	C	C	G			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr19:22154888C>G	ENST00000397126.4	-	4	3096	c.2948G>C	c.(2947-2949)aGt>aCt	p.S983T	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGAGAATGTACTAAAGCCTTT	0.358000													5	54					0	0	1	0	0
NCF4	4689	broad.mit.edu	37	22	37268425	37268425	+	Missense_Mutation	SNP	T	T	A			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr22:37268425T>A	ENST00000397147.4	+	7	769	c.585T>A	c.(583-585)gaT>gaA	p.D195E	NCF4_ENST00000248899.6_Missense_Mutation_p.D195E	NM_013416.3	NP_038202.2	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4, 40kDa	195	SH3.				cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			cervix(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						AAGCTGGAGATGTGATCTTCC	0.478000													27	67					0	0	1	0	0
ZNF551	90233	broad.mit.edu	37	19	58199603	58199603	+	Missense_Mutation	SNP	C	C	T	rs139249482	by1000genomes	TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr19:58199603C>T	ENST00000282296.5	+	3	2145	c.1960C>T	c.(1960-1962)Cgc>Tgc	p.R654C	ZNF551_ENST00000356715.4_Missense_Mutation_p.R638C|AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000594684.1_Intron|ZNF551_ENST00000596085.1_Intron			Q7Z340	ZN551_HUMAN	zinc finger protein 551	654					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		ATCCTTTAGCCGCAAATCTAA	0.418000													11	116					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5294667	5294667	+	Missense_Mutation	SNP	G	G	A	rs142008002		TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr20:5294667G>A	ENST00000546004.1	-	2	595	c.349C>T	c.(349-351)Cgg>Tgg	p.R117W	PROKR2_ENST00000217270.3_Missense_Mutation_p.R117W			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	117						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						GAGAGCTGCCGTACCACGTAG	0.597000										HNSCC(71;0.22)			12	36					0	0	1	0	0
KRTCAP3	200634	broad.mit.edu	37	2	27665758	27665758	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr2:27665758G>A	ENST00000543753.1	+	3	310	c.263G>A	c.(262-264)cGc>cAc	p.R88H	KRTCAP3_ENST00000288873.3_Missense_Mutation_p.R88H|KRTCAP3_ENST00000407293.1_Missense_Mutation_p.R70H	NM_001168364.1	NP_001161836.1	Q53RY4	KCP3_HUMAN	keratinocyte associated protein 3	88						integral to membrane				large_intestine(1)|lung(2)	3	Acute lymphoblastic leukemia(172;0.155)					AACCTTCTTCGCCCTCCACTG	0.587000													12	91					0	0	1	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254054	39254054	+	Missense_Mutation	SNP	A	A	T	rs76270529	by1000genomes	TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr17:39254054A>T	ENST00000333822.4	-	1	339	c.283T>A	c.(283-285)Tgc>Agc	p.C95S		NM_031960.2	NP_114166.1	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4-8	95	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament		p.C95S(4)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)	11						ctggagatgcagcagcTAGGG	0.677000													4	50					0	0	1	0	0
UNC5CL	222643	broad.mit.edu	37	6	41002719	41002719	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr6:41002719C>T	ENST00000244565.3	-	2	183	c.95G>A	c.(94-96)cGa>cAa	p.R32Q	UNC5CL_ENST00000373164.1_Missense_Mutation_p.R32Q	NM_173561.2	NP_775832.2	Q8IV45	UN5CL_HUMAN	unc-5 homolog C (C. elegans)-like	32					signal transduction	cytoplasm|integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	13	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCAGTGCCATCGAAGGCATTG	0.587000													10	45					0	0	1	0	0
RP11-404F10.2	0	broad.mit.edu	37	1	160640798	160640798	+	RNA	DEL	T	T	-			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr1:160640798delT	ENST00000598917.2	+	0	231																											TTCTGAACAATTTTTTTTTTA	0.428													3	5	---	---	---	---					
RYR2	6262	broad.mit.edu	37	1	237889610	237889611	+	Splice_Site	INS	-	-	A			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr1:237889610_237889611insA	ENST00000366574.2	+	75	11042		c.e75+2		RYR2_ENST00000542537.1_Splice_Site|RYR2_ENST00000360064.6_Splice_Site|RYR2_ENST00000609119.1_Splice_Site	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TACTGTCTGGGAAGTACAGTGC	0.312													2	4	---	---	---	---					
TRBV29-1	28558	broad.mit.edu	37	7	142448200	142448207	+	RNA	DEL	GGTGGAAA	GGTGGAAA	-	rs149832120	by1000genomes	TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr7:142448200_142448207delGGTGGAAA	ENST00000422143.2	+	0	101																											GTTAACACTGGGTGGAAAGGTGGAAAGA	0.457													4	6	---	---	---	---					
ISCA1	81689	broad.mit.edu	37	9	88897352	88897352	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr9:88897352delC	ENST00000375991.4	-	1	92	c.22delG	c.(22-24)gcafs	p.A8fs	ISCA1_ENST00000452279.2_Frame_Shift_Del_p.A55fs|ISCA1_ENST00000326094.4_Frame_Shift_Del_p.A8fs	NM_030940.3	NP_112202.2	Q9BUE6	ISCA1_HUMAN	iron-sulfur cluster assembly 1	8					iron-sulfur cluster assembly	mitochondrion	iron-sulfur cluster binding|metal ion binding|structural molecule activity			endometrium(2)|large_intestine(1)|lung(4)|pancreas(1)	8				OV - Ovarian serous cystadenocarcinoma(323;5.4e-34)|Lung(182;0.0375)		CGGACAGTTGCCCGGACTAAG	0.711													2	4	---	---	---	---					
RTL1	388015	broad.mit.edu	37	14	101350670	101350671	+	In_Frame_Ins	INS	-	-	TCT	rs55755518	by1000genomes	TCGA-DH-A7UT-01A-12D-A34A-08	TCGA-DH-A7UT-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1f9300e8-f1e0-46d6-bb2b-4233112d5787	58237222-ac10-45c2-b564-57672b993059	g.chr14:101350670_101350671insTCT	ENST00000534062.1	-	1	513_514	c.455_456insAGA	c.(454-456)gag>gaAGAg	p.152_152E>EE		NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	152										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						TCTGGTTTTGCTCTTGAGGAGT	0.520													4	5	---	---	---	---					
