Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CRAMP1L	57585	broad.mit.edu	37	16	1715128	1715128	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr16:1715128C>G	ENST00000397412.3	+	14	2840	c.2741C>G	c.(2740-2742)tCt>tGt	p.S914C	LA16c-431H6.6_ENST00000454337.1_3'UTR|CRAMP1L_ENST00000293925.5_Missense_Mutation_p.S914C|CRAMP1L_ENST00000436138.3_Missense_Mutation_p.S911C|CRAMP1L_ENST00000262317.4_Missense_Mutation_p.S292C			Q96RY5	CRML_HUMAN	Crm, cramped-like (Drosophila)	914						nucleus	DNA binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)	22						CTGTCTAACTCTTCCGTAACT	0.507000													13	25					0	0	1	0	0
MCM6	4175	broad.mit.edu	37	2	136622582	136622582	+	Splice_Site	SNP	C	C	G			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr2:136622582C>G	ENST00000264156.2	-	7	1139		c.e7+1		MCM6_ENST00000492091.1_Splice_Site	NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6						cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	GGAATTCTTACCATGTATAGT	0.343000													40	76					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56510346	56510346	+	Missense_Mutation	SNP	C	C	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr11:56510346C>A	ENST00000302957.3	-	1	941	c.942G>T	c.(940-942)gaG>gaT	p.E314D		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	314					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						TCCTGAAGGCCTCTTTGATAT	0.408000													52	71					2.64514e-33	3.065e-33	1	1	0
MTUS2	23281	broad.mit.edu	37	13	29600875	29600875	+	Silent	SNP	C	C	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr13:29600875C>T	ENST00000431530.3	+	1	2128	c.2070C>T	c.(2068-2070)caC>caT	p.H690H		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	680	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CTCTTCCCCACGAAGAGAAGG	0.582000													13	18					0	0	1	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43475375	43475375	+	Silent	SNP	G	G	A	rs138914274		TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr17:43475375G>A	ENST00000532038.1	-	9	1251	c.1116C>T	c.(1114-1116)caC>caT	p.H372H	ARHGAP27_ENST00000376922.2_Silent_p.H253H|ARHGAP27_ENST00000442348.1_Silent_p.H567H|ARHGAP27_ENST00000455881.1_Silent_p.H253H|ARHGAP27_ENST00000532891.2_Silent_p.H572H|ARHGAP27_ENST00000528384.1_Silent_p.H226H|ARHGAP27_ENST00000428638.1_Silent_p.H594H|ARHGAP27_ENST00000582826.1_5'UTR			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	594					positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					CCTCCGAGTCGTGCTGGATCA	0.632000													32	41					0	0	1	0	0
USP36	57602	broad.mit.edu	37	17	76803536	76803536	+	Silent	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr17:76803536G>A	ENST00000542802.3	-	14	2033	c.1590C>T	c.(1588-1590)gaC>gaT	p.D530D	USP36_ENST00000449938.2_Silent_p.D230D|USP36_ENST00000312010.6_Silent_p.D530D			Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36						ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	34			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			TTCCAGGGTCGTCTAGGATGG	0.587000													14	16					0	0	1	0	0
SIGLEC16	400709	broad.mit.edu	37	19	50473580	50473580	+	RNA	SNP	C	C	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr19:50473580C>T	ENST00000602139.1	+	0	450									sialic acid binding Ig-like lectin 16 (gene/pseudogene)											endometrium(2)|kidney(2)|lung(6)	10						TCTGCCCCAGCCCTGACTCAG	0.607000													32	135					0	0	1	0	0
GSTM4	2948	broad.mit.edu	37	1	110201727	110201727	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr1:110201727T>C	ENST00000369833.1	+	5	1353	c.439T>C	c.(439-441)Ttt>Ctt	p.F147L	GSTM4_ENST00000326729.5_Missense_Mutation_p.F188L|GSTM4_ENST00000495742.1_3'UTR|GSTM4_ENST00000336075.5_Missense_Mutation_p.F127L|GSTM4_ENST00000369836.4_Missense_Mutation_p.F188L			Q03013	GSTM4_HUMAN	glutathione S-transferase mu 4	188	GST C-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	12		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0123)|Colorectal(144;0.0129)|Epithelial(280;0.0147)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.0471)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	CATCTCCCGCTTTGAGGTGAT	0.478000													6	221					0	0	1	0	0
OR4K13	390433	broad.mit.edu	37	14	20502653	20502653	+	Missense_Mutation	SNP	G	G	A	rs149397731	byFrequency	TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr14:20502653G>A	ENST00000315693.2	-	1	266	c.265C>T	c.(265-267)Cgt>Tgt	p.R89C		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		ATGGTCTTACGTTCTCGGAGG	0.453000													21	27					0	0	1	0	0
EID2B	126272	broad.mit.edu	37	19	40023046	40023046	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr19:40023046C>G	ENST00000326282.4	-	1	448	c.397G>C	c.(397-399)Gac>Cac	p.D133H	EID2B_ENST00000601837.1_Intron	NM_152361.1	NP_689574.1	Q96D98	EID2B_HUMAN	EP300 interacting inhibitor of differentiation 2B	133					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				endometrium(1)|lung(1)|urinary_tract(1)	3	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;8.61e-26)|all cancers(26;2.76e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGATCCGCGTCAAAGGCTGCT	0.602000													20	55					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128341727	128341727	+	Silent	SNP	C	C	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr2:128341727C>T	ENST00000389524.4	+	13	1427	c.1374C>T	c.(1372-1374)aaC>aaT	p.N458N	MYO7B_ENST00000428314.1_Silent_p.N458N|MYO7B_ENST00000409816.2_Silent_p.N458N			Q6PIF6	MYO7B_HUMAN	myosin VIIB	458	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ACTTCGCCAACGAGCACCTGC	0.597000													13	20					0	0	1	0	0
TMEM130	222865	broad.mit.edu	37	7	98453658	98453658	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr7:98453658C>T	ENST00000450876.1	-	4	1763	c.448G>A	c.(448-450)Gcc>Acc	p.A150T	TMEM130_ENST00000546258.1_Missense_Mutation_p.A215T|TMEM130_ENST00000416379.2_Missense_Mutation_p.A234T|TMEM130_ENST00000345589.4_Missense_Mutation_p.A132T|TMEM130_ENST00000339375.4_Missense_Mutation_p.A234T			Q8N3G9	TM130_HUMAN	transmembrane protein 130	234	PKD.					Golgi membrane|integral to membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	25	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TTCAGCGAGGCGGAGAAGTCC	0.632000													8	23					0	0	1	0	0
MEIS2	4212	broad.mit.edu	37	15	37186973	37186973	+	Silent	SNP	C	C	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr15:37186973C>T	ENST00000444725.1	-	12	2203	c.1167G>A	c.(1165-1167)ggG>ggA	p.G389G	MEIS2_ENST00000340545.5_Silent_p.G376G|MEIS2_ENST00000338564.5_Intron|MEIS2_ENST00000397620.2_Silent_p.G301G|MEIS2_ENST00000219869.9_Silent_p.G250G|MEIS2_ENST00000557796.2_Silent_p.G376G|MEIS2_ENST00000382766.2_Intron|MEIS2_ENST00000397624.3_Silent_p.G301G|MEIS2_ENST00000559085.1_Silent_p.G383G|MEIS2_ENST00000559561.1_Silent_p.G389G|MEIS2_ENST00000424352.2_Silent_p.G396G|MEIS2_ENST00000561208.1_Intron	NM_170674.4|NM_170677.4	NP_733774.1|NP_733777.1	O14770	MEIS2_HUMAN	Meis homeobox 2	396					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	36		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		AGTGCCATTGCCCATCCATGC	0.438000													4	131					0	0	1	0	0
IGLV3-22	28795	broad.mit.edu	37	22	23047120	23047120	+	RNA	SNP	G	G	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr22:23047120G>T	ENST00000390307.2	+	0	222																											TATGCTGACTGGTACCAGCAG	0.557000													39	55					1.96642e-18	2.20844e-18	1	1	0
OR5C1	392391	broad.mit.edu	37	9	125551964	125551964	+	Silent	SNP	C	C	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr9:125551964C>T	ENST00000373680.2	+	1	815	c.753C>T	c.(751-753)gcC>gcT	p.A251A		NM_001001923.1	NP_001001923.1	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C, member 1	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(6)|pancreas(1)|prostate(5)|skin(1)	20						ACCTCACAGCCGTGGCCATGA	0.597000													34	50					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126137511	126137511	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr3:126137511G>C	ENST00000393425.1	+	7	646	c.547G>C	c.(547-549)Gag>Cag	p.E183Q	CCDC37_ENST00000505024.1_Missense_Mutation_p.E183Q|CCDC37_ENST00000352312.1_Missense_Mutation_p.E182Q			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	182										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		GGCGACCAAAGAGGAGGCCAG	0.647000													5	2					0	0	1	0	0
GPC3	2719	broad.mit.edu	37	X	132888183	132888183	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chrX:132888183G>A	ENST00000370818.3	-	3	803	c.358C>T	c.(358-360)Cgc>Tgc	p.R120C	GPC3_ENST00000543339.1_Missense_Mutation_p.R66C|GPC3_ENST00000394299.2_Missense_Mutation_p.R120C	NM_001164618.1|NM_004484.3	NP_001158090.1|NP_004475.1	P51654	GPC3_HUMAN	glypican 3	120						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|prostate(1)|skin(2)	36	Acute lymphoblastic leukemia(192;0.000127)					TTGGCATGGCGAACAACAATT	0.363000			"""T, D, Mis, N, F, S"""			Wilms tumour			Simpson-Golabi-Behmel syndrome				76	4					0	0	1	0	0
PTGFRN	5738	broad.mit.edu	37	1	117487662	117487662	+	Silent	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr1:117487662G>A	ENST00000393203.2	+	3	927	c.780G>A	c.(778-780)caG>caA	p.Q260Q		NM_020440.2	NP_065173.2	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor inhibitor	260	Ig-like C2-type 2.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)	46	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		GCAACTGGCAGGAAATCCAAG	0.567000													17	21					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41004898	41004898	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr5:41004898G>C	ENST00000399564.4	-	36	4439	c.3989C>G	c.(3988-3990)aCa>aGa	p.T1330R	MROH2B_ENST00000506092.2_Missense_Mutation_p.T885R	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CCCGGATGCTGTGTTGCCGAG	0.478000													30	44					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16261678	16261678	+	Silent	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr1:16261678G>A	ENST00000375759.3	+	11	9147	c.8943G>A	c.(8941-8943)acG>acA	p.T2981T		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	2981					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TGGGGTCCACGCTCACGCCCC	0.597000													3	43					0	0	1	0	0
OR1N1	138883	broad.mit.edu	37	9	125289050	125289050	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr9:125289050A>G	ENST00000304880.2	-	1	522	c.523T>C	c.(523-525)Ttt>Ctt	p.F175L		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						TCACAGAAAAAGTGAGCAATT	0.502000													20	19					0	0	1	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58846117	58846117	+	Splice_Site	SNP	G	G	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr19:58846117G>T	ENST00000329665.4	+	2	96		c.e2-1			NM_181846.2	NP_862829.1	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|pancreas(1)|prostate(2)	16		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		CATTCCTGCAGGCCCAGTTCC	0.597000													4	10					0.150653	0.154897	1	1	0
TTN	7273	broad.mit.edu	37	2	179453326	179453326	+	Silent	SNP	A	A	G			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr2:179453326A>G	ENST00000589042.1	-	304	63350	c.63126T>C	c.(63124-63126)aaT>aaC	p.N21042N	TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.N12102N|TTN_ENST00000460472.2_Silent_p.N11977N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Silent_p.N12169N|TTN_ENST00000591111.1_Silent_p.N19401N|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Silent_p.N18474N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19401	Fibronectin type-III 52.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCAATTTCATTTTCTGCCT	0.453000													13	248					0	0	1	0	0
OR10G8	219869	broad.mit.edu	37	11	123901065	123901065	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr11:123901065G>A	ENST00000431524.1	+	1	769	c.736G>A	c.(736-738)Gtg>Atg	p.V246M		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	246					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CCACTGTATCGTGGTCCTTTG	0.542000													57	64					0	0	1	0	0
PXMP4	11264	broad.mit.edu	37	20	32308005	32308005	+	Silent	SNP	G	G	C			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr20:32308005G>C	ENST00000409299.3	-	1	101	c.9C>G	c.(7-9)gcC>gcG	p.A3A	PXMP4_ENST00000344022.3_Silent_p.A3A|PXMP4_ENST00000217398.3_Silent_p.A3A	NM_007238.4	NP_009169.3	Q9Y6I8	PXMP4_HUMAN	peroxisomal membrane protein 4, 24kDa	3						integral to membrane|membrane fraction|mitochondrial inner membrane|peroxisomal membrane	protein transporter activity			NS(1)|endometrium(2)|large_intestine(2)|lung(8)	13						GCTGCGGCGGGGCTGCCATAG	0.682000													10	19					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107427813	107427813	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr7:107427813C>T	ENST00000340010.5	-	7	1061	c.877G>A	c.(877-879)Gaa>Aaa	p.E293K	SLC26A3_ENST00000422236.2_Missense_Mutation_p.E258K	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	293					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						ATAATGAATTCGATTGGAATG	0.378000													72	142					0	0	1	0	0
TRIM15	89870	broad.mit.edu	37	6	30136149	30136149	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr6:30136149C>T	ENST00000376694.4	+	3	1019	c.550C>T	c.(550-552)Cga>Tga	p.R184*	TRIM15_ENST00000376688.1_Intron	NM_033229.2	NP_150232.2	Q9C019	TRI15_HUMAN	tripartite motif containing 15	184					mesodermal cell fate determination	intracellular	zinc ion binding			large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	14						GGAGCAGCAGCGATGTCTCCT	0.527000													19	27					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162172	90162172	+	RNA	SNP	T	T	C			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr16:90162172T>C	ENST00000564451.1	+	0	1525				TUBB8P7_ENST00000567960.1_RNA																							GATGGCTGCCTGTGACCCCCG	0.567000													4	115					0	0	1	0	0
IGKV1-6	28943	broad.mit.edu	37	2	89266236	89266236	+	RNA	SNP	G	G	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr2:89266236G>T	ENST00000464162.1	-	0	50																											CCCAGGAGCTGAGCGGGGACC	0.577000													63	145					1.02487e-32	1.16899e-32	1	1	0
TNFSF13B	10673	broad.mit.edu	37	13	108922745	108922745	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr13:108922745C>T	ENST00000375887.4	+	2	575	c.397C>T	c.(397-399)Cgt>Tgt	p.R133C	TNFSF13B_ENST00000542136.1_Missense_Mutation_p.R133C|TNFSF13B_ENST00000430559.1_Missense_Mutation_p.R133C|TNFSF13B_ENST00000479435.1_3'UTR	NM_006573.4	NP_006564.1	Q9Y275	TN13B_HUMAN	tumor necrosis factor (ligand) superfamily, member 13b	133		Cleavage.			cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding			large_intestine(1)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)			CAGAAATAAGCGTGCCGTTCA	0.463000													23	48					0	0	1	0	0
GABRA4	2557	broad.mit.edu	37	4	46967202	46967202	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr4:46967202G>A	ENST00000264318.3	-	8	1901	c.919C>T	c.(919-921)Cga>Tga	p.R307*		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	307					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAAGAATGTCGTGCACTGATG	0.433000													45	77					0	0	1	0	0
CRCT1	54544	broad.mit.edu	37	1	152487972	152487972	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr1:152487972C>G	ENST00000368790.3	+	2	186	c.113C>G	c.(112-114)tCc>tGc	p.S38C		NM_019060.2	NP_061933.1	Q9UGL9	CRCT1_HUMAN	cysteine-rich C-terminal 1	38										lung(1)|ovary(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			tcctcctcctccTGCTGCGGC	0.736000													3	27					0	0	1	0	0
SPEF1	25876	broad.mit.edu	37	20	3760357	3760357	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr20:3760357C>T	ENST00000379756.3	-	2	335	c.175G>A	c.(175-177)Gcc>Acc	p.A59T	SPEF1_ENST00000463490.1_5'UTR	NM_015417.4	NP_056232.2	Q9Y4P9	SPEF1_HUMAN	sperm flagellar 1	59						cilium axoneme|cytoplasm|cytoskeleton				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8						AGAGAGTTGGCGGGGACATAA	0.537000													21	40					0	0	1	0	0
KLRC4-KLRK1	100528032	broad.mit.edu	37	12	10562063	10562063	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr12:10562063T>C	ENST00000539300.1	-	1	85	c.86A>G	c.(85-87)aAt>aGt	p.N29S	KLRC4_ENST00000309384.1_Missense_Mutation_p.I38V																							ACTTGGAATATTTCCTGTTTG	0.388000													66	89					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140964211	140964211	+	Splice_Site	SNP	A	A	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr9:140964211A>T	ENST00000371372.1	+	32	4815	c.4670A>T	c.(4669-4671)gAa>gTa	p.E1557V	CACNA1B_ENST00000371355.4_Intron|CACNA1B_ENST00000371357.1_Intron|CACNA1B_ENST00000277549.5_Intron|CACNA1B_ENST00000277551.2_Splice_Site_p.E1557V|CACNA1B_ENST00000371363.1_Intron	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1557					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CACATGTAGGAAACGGTTGGT	0.488000													4	6					0	0	1	0	0
ADH1C	126	broad.mit.edu	37	4	100257916	100257916	+	RNA	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr4:100257916G>A	ENST00000515683.1	-	0	1472					NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	GTTTCAAAACGTCAGGACGGT	0.423000													27	25					0	0	1	0	0
LPIN2	9663	broad.mit.edu	37	18	2951271	2951271	+	Silent	SNP	T	T	C			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr18:2951271T>C	ENST00000261596.4	-	4	610	c.372A>G	c.(370-372)aaA>aaG	p.K124K	RP11-737O24.2_ENST00000584431.1_RNA	NM_014646.2	NP_055461.1	Q92539	LPIN2_HUMAN	lipin 2	124					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	29				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		CTCCACCCGATTTCACCAAAG	0.413000													54	60					0	0	1	0	0
PPIL2	23759	broad.mit.edu	37	22	22024879	22024879	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr22:22024879G>A	ENST00000335025.8	+	3	198	c.107G>A	c.(106-108)cGt>cAt	p.R36H	PPIL2_ENST00000492445.2_Missense_Mutation_p.R36H|PPIL2_ENST00000412327.1_Missense_Mutation_p.R36H|PPIL2_ENST00000406385.1_Missense_Mutation_p.R36H|PPIL2_ENST00000456792.2_Missense_Mutation_p.R36H|PPIL2_ENST00000398831.3_Missense_Mutation_p.R36H			Q13356	PPIL2_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 2						blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	17	Colorectal(54;0.105)					AATTTTCGTCGTTTACCTTTT	0.373000													81	122					0	0	1	0	0
ETNK1	55500	broad.mit.edu	37	12	22778194	22778194	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr12:22778194A>G	ENST00000266517.4	+	1	186	c.97A>G	c.(97-99)Aac>Gac	p.N33D	ETNK1_ENST00000335148.3_Missense_Mutation_p.N33D	NM_018638.4	NP_061108.2	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1	33					phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CCGGATCGGCAACAGTGCCGC	0.711000													5	12					0	0	1	0	0
PFKL	5211	broad.mit.edu	37	21	45732145	45732145	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr21:45732145G>A	ENST00000403390.1	+	5	536	c.536G>A	c.(535-537)tGg>tAg	p.W179*	PFKL_ENST00000496824.1_3'UTR|PFKL_ENST00000349048.4_Nonsense_Mutation_p.W132*			P17858	K6PL_HUMAN	phosphofructokinase, liver	132					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		CGCAGCGAGTGGGGCAGCCTG	0.662000													5	15					0	0	1	0	0
KIAA0408	9729	broad.mit.edu	37	6	127771491	127771491	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr6:127771491G>A	ENST00000483725.3	-	3	478	c.142C>T	c.(142-144)Cgg>Tgg	p.R48W	SOGA3_ENST00000556132.1_3'UTR|SOGA3_ENST00000481848.2_3'UTR|SOGA3_ENST00000368268.2_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	48							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		TTTACTTCCCGGCAAAGCTGT	0.338000													4	65					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78943064	78943064	+	Silent	SNP	C	C	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr9:78943064C>T	ENST00000545128.1	+	32	4936	c.4398C>T	c.(4396-4398)ccC>ccT	p.P1466P		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	633					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						AGGATGCTCCCGGGTGCAAGC	0.582000													61	75					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11098794	11098794	+	RNA	SNP	C	C	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr21:11098794C>T	ENST00000470054.1	-	0	131									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		actccagctgcgctgccatct	0.627000													8	66					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90500708	90500708	+	Missense_Mutation	SNP	C	C	T	rs150988108	byFrequency	TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr9:90500708C>T	ENST00000325643.5	+	4	1372	c.1306C>T	c.(1306-1308)Cgc>Tgc	p.R436C		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		ACAGCAGAAACGCAGCCAGCT	0.562000													54	64					0	0	1	0	0
CHIA	27159	broad.mit.edu	37	1	111861169	111861169	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr1:111861169G>A	ENST00000369740.1	+	9	887	c.784G>A	c.(784-786)Gtt>Att	p.V262I	CHIA_ENST00000430615.1_Missense_Mutation_p.V154I|CHIA_ENST00000353665.6_Missense_Mutation_p.V101I|CHIA_ENST00000343320.6_Missense_Mutation_p.V262I|CHIA_ENST00000451398.2_Missense_Mutation_p.V101I|RP5-1125M8.2_ENST00000426321.1_RNA|CHIA_ENST00000483391.1_Missense_Mutation_p.V101I	NM_001258001.1|NM_201653.3	NP_001244930.1|NP_970615.2	Q9BZP6	CHIA_HUMAN	chitinase, acidic	262					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding	p.V154I(1)|p.V262I(1)		central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		GAAGCTCATCGTTGGATTCCC	0.537000													40	53					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32181593	32181593	+	Missense_Mutation	SNP	G	G	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr6:32181593G>T	ENST00000375023.3	-	14	2330	c.2192C>A	c.(2191-2193)aCa>aAa	p.T731K	NOTCH4_ENST00000465528.1_5'UTR	NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	731	EGF-like 19.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GTGACAAGCTGTCATCTCCTC	0.597000													3	41					1	1	1	1	0
ACTBL2	345651	broad.mit.edu	37	5	56777838	56777838	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr5:56777838C>T	ENST00000423391.1	-	1	798	c.697G>A	c.(697-699)Gca>Aca	p.A233T	CTD-2023N9.1_ENST00000506106.1_RNA	NM_001017992.3	NP_001017992.1	Q562R1	ACTBL_HUMAN	actin, beta-like 2	233						cytoplasm|cytoskeleton	ATP binding	p.A233T(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(3)|pancreas(1)|prostate(2)	28		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		GAGGAGGATGCGGCTGCCCTG	0.547000													22	41					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46279833	46279833	+	Silent	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr20:46279833G>A	ENST00000372004.3	+	20	3963	c.3747G>A	c.(3745-3747)caG>caA	p.Q1249Q	NCOA3_ENST00000341724.6_Silent_p.Q1179Q|NCOA3_ENST00000371997.3_Silent_p.Q1244Q|NCOA3_ENST00000371998.3_Silent_p.Q1253Q	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1253	Acetyltransferase.|Poly-Gln.		Missing.		androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						agcagcagcagcaacagcagc	0.547000													4	92					0	0	1	0	0
TRIM17	51127	broad.mit.edu	37	1	228602614	228602614	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr1:228602614G>A	ENST00000366697.2	-	1	1116	c.160C>T	c.(160-162)Cgg>Tgg	p.R54W	TRIM17_ENST00000456946.2_Missense_Mutation_p.R54W|TRIM17_ENST00000366698.2_Missense_Mutation_p.R54W|TRIM17_ENST00000295033.3_Missense_Mutation_p.R54W			Q9Y577	TRI17_HUMAN	tripartite motif containing 17	54					protein autoubiquitination	intracellular	protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)	10		Prostate(94;0.0724)				TTCCGCTTCCGCCTCCCCTTC	0.632000													13	19					0	0	1	0	0
RPL5	6125	broad.mit.edu	37	1	93300378	93300378	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr1:93300378G>C	ENST00000370321.3	+	4	322	c.232G>C	c.(232-234)Gcg>Ccg	p.A78P		NM_000969.3	NP_000960.2	P46777	RL5_HUMAN	ribosomal protein L5	78				A -> R (in Ref. 1; AAA85654).	endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		AGTCTGCGCAGCGTATGCACA	0.458000													56	81					0	0	1	0	0
C9orf3	84909	broad.mit.edu	37	9	97844955	97844955	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr9:97844955G>A	ENST00000375315.2	+	15	2418	c.2418G>A	c.(2416-2418)atG>atA	p.M806I	C9orf3_ENST00000297979.5_Missense_Mutation_p.M707I|C9orf3_ENST00000433691.2_Missense_Mutation_p.M147I|C9orf3_ENST00000425634.2_Missense_Mutation_p.M168I	NM_001193329.1	NP_001180258.1	Q8N6M6	AMPO_HUMAN	chromosome 9 open reading frame 3	806					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		AGGAGCAGATGGATAGGTCCT	0.527000													24	32					0	0	1	0	0
CHRNG	1146	broad.mit.edu	37	2	233409542	233409542	+	Missense_Mutation	SNP	C	C	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr2:233409542C>A	ENST00000389494.3	+	11	1331	c.1310C>A	c.(1309-1311)gCc>gAc	p.A437D	CHRNG_ENST00000389492.3_Missense_Mutation_p.A385D	NM_005199.4	NP_005190.4	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma (muscle)	437					muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity			breast(2)|endometrium(3)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		GCTGCCCCAGCCATCCAGGCC	0.572000													35	38					1.45844e-13	1.61312e-13	1	1	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													4	46					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155721974	155721974	+	Silent	SNP	G	G	T			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr1:155721974G>T	ENST00000437809.1	-	30	6369	c.6247C>A	c.(6247-6249)Cgg>Agg	p.R2083R	GON4L_ENST00000368331.1_Silent_p.R2084R|GON4L_ENST00000271883.5_Silent_p.R2083R	NM_001282856.1	NP_001269785.1	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	2084					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding	p.R2083W(1)		NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GTCTTCACCCGAGCTCTGCTT	0.532000													4	123					3.59834e-05	3.75255e-05	1	1	0
IGF2BP1	10642	broad.mit.edu	37	17	47120867	47120867	+	Silent	SNP	G	G	A			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr17:47120867G>A	ENST00000290341.3	+	10	1489	c.1155G>A	c.(1153-1155)ccG>ccA	p.P385P	IGF2BP1_ENST00000431824.2_Silent_p.P246P	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	385	Necessary for interaction with ELAVL4 and binding to TAU mRNA (By similarity).				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						CAGTCCCGCCGCCTCCCAGCA	0.572000													25	28					0	0	1	0	0
PTPN18	26469	broad.mit.edu	37	2	131129929	131129934	+	In_Frame_Del	DEL	GACGGG	GACGGG	-	rs112040677		TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr2:131129929_131129934delGACGGG	ENST00000175756.5	+	13	1214_1219	c.1113_1118delGACGGG	c.(1111-1119)cagacgggg>cag	p.TG378del	PTPN18_ENST00000347849.3_In_Frame_Del_p.TG271del	NM_014369.3	NP_055184.2	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	378				Missing (in Ref. 1; CAA56105).		cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity	p.T378_G379delTG(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)	15	Colorectal(110;0.1)					gtgggacgcagacggggacggggacg	0.777													5	3	---	---	---	---					
PIK3R1	5295	broad.mit.edu	37	5	67591150	67591151	+	Splice_Site	DEL	GA	GA	-			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr5:67591150_67591151delGA	ENST00000521381.1	+	13	2359_2360	c.1743_1744delGA	c.(1741-1746)ttgatg>tttg	p.LM581fs	PIK3R1_ENST00000336483.5_Splice_Site_p.LM311fs|PIK3R1_ENST00000521657.1_Splice_Site_p.LM581fs|PIK3R1_ENST00000523872.1_Splice_Site_p.LM218fs|PIK3R1_ENST00000274335.5_Splice_Site_p.LM581fs|PIK3R1_ENST00000320694.8_Splice_Site_p.LM281fs|PIK3R1_ENST00000396611.1_Splice_Site_p.LM581fs	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	581					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.R577_M582>K(1)|p.Y580fs*1(1)|p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	ACCAATACTTGATGTAAGTATT	0.376			"""Mis, F, O"""		"""gliobastoma, ovarian, colorectal"""					TCGA GBM(4;<1E-08)			18	48	---	---	---	---					
PIK3R1	5295	broad.mit.edu	37	5	67591153	67591153	+	Splice_Site	DEL	G	G	-			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr5:67591153delG	ENST00000521381.1	+	13	2361		c.e13+1		PIK3R1_ENST00000336483.5_Splice_Site|PIK3R1_ENST00000521657.1_Splice_Site|PIK3R1_ENST00000523872.1_Splice_Site|PIK3R1_ENST00000274335.5_Splice_Site|PIK3R1_ENST00000320694.8_Splice_Site|PIK3R1_ENST00000396611.1_Splice_Site	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)						epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.R577_M582>K(1)|p.Y580fs*1(1)|p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	AATACTTGATGTAAGTATTTG	0.373			"""Mis, F, O"""		"""gliobastoma, ovarian, colorectal"""					TCGA GBM(4;<1E-08)			35	28	---	---	---	---					
TRBV29-1	28558	broad.mit.edu	37	7	142448200	142448207	+	RNA	DEL	GGTGGAAA	GGTGGAAA	-	rs149832120	by1000genomes	TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr7:142448200_142448207delGGTGGAAA	ENST00000422143.2	+	0	101																											GTTAACACTGGGTGGAAAGGTGGAAAGA	0.457													6	12	---	---	---	---					
ZNF618	114991	broad.mit.edu	37	9	116798603	116798603	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr9:116798603delG	ENST00000288466.7	+	12	1012	c.913delG	c.(913-915)gggfs	p.G305fs	ZNF618_ENST00000374126.5_Frame_Shift_Del_p.G398fs|ZNF618_ENST00000470105.1_3'UTR	NM_133374.2	NP_588615.2	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|lung(10)|urinary_tract(1)	16						CGGCGCCTGTGGGATCCAGTT	0.587													2	4	---	---	---	---					
MIR7162	102466227	broad.mit.edu	37	15	62539153	62539154	+	RNA	INS	-	-	GG	rs113348682	by1000genomes	TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr15:62539153_62539154insGG	ENST00000570077.1	-	0	362																											TCCACCTCTCTGGCATTCTAAG	0.569													2	4	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chr17:45219612delA	ENST00000066544.3	-	11	1454	c.1361delT	c.(1360-1362)ctafs	p.L454fs	CDC27_ENST00000531206.1_Frame_Shift_Del_p.L460fs|CDC27_ENST00000446365.2_Frame_Shift_Del_p.L393fs|CDC27_ENST00000527547.1_Frame_Shift_Del_p.L454fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													7	48	---	---	---	---					
GAGE2D	729408	broad.mit.edu	37	X	49208295	49208296	+	In_Frame_Ins	INS	-	-	TAT			TCGA-DU-A7TJ-01A-11D-A34J-08	TCGA-DU-A7TJ-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e423faad-225f-4505-b3ae-0b142263357d	06cf2071-92a5-4732-a699-a6d86bd996b0	g.chrX:49208295_49208296insTAT	ENST00000404720.2	+	2	96_97	c.24_25insTAT	c.(25-27)tat>TATtat	p.9_9Y>YY		NM_001098407.1|NM_012196.1	NP_001091877.1|NP_036328.1			G antigen 2D																		GAAGATCGACCTATCGGCCTAG	0.465													3	5	---	---	---	---					
