Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CMTM3	123920	broad.mit.edu	37	16	66643846	66643846	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr16:66643846G>A	ENST00000424011.2	+	5	986	c.460G>A	c.(460-462)Gtg>Atg	p.V154M	CMTM3_ENST00000567572.1_Missense_Mutation_p.V154M|CMTM3_ENST00000568477.1_Missense_Mutation_p.V68M|CMTM3_ENST00000562707.1_Missense_Mutation_p.V154M|CMTM3_ENST00000565922.1_Intron|CMTM3_ENST00000360086.4_Intron|CMTM3_ENST00000565003.1_Missense_Mutation_p.V68M|CMTM3_ENST00000566121.1_Missense_Mutation_p.V68M|CMTM3_ENST00000564060.1_Missense_Mutation_p.V122M|CMTM3_ENST00000460097.1_Missense_Mutation_p.V68M|CMTM3_ENST00000565666.1_3'UTR|CMTM3_ENST00000361909.4_Missense_Mutation_p.V154M			Q96MX0	CKLF3_HUMAN	CKLF-like MARVEL transmembrane domain containing 3	154	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			central_nervous_system(1)|endometrium(1)|lung(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0671)|Epithelial(162;0.164)		CTTTAACGACGTGGCCAAATT	0.527000													7	73					0	0	1	0	0
HTR1D	3352	broad.mit.edu	37	1	23520183	23520183	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr1:23520183C>T	ENST00000374619.1	-	1	1039	c.530G>A	c.(529-531)cGg>cAg	p.R177Q	HTR1D_ENST00000314113.3_Missense_Mutation_p.R177Q	NM_000864.4	NP_000855.1	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	177					G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity	p.R177Q(1)		NS(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	CTTGGCCTGCCGCCAGAAGAG	0.597000													17	32					0	0	1	0	0
ARFGAP2	84364	broad.mit.edu	37	11	47196860	47196860	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr11:47196860G>A	ENST00000524782.1	-	4	497	c.269C>T	c.(268-270)gCt>gTt	p.A90V	ARFGAP2_ENST00000426335.2_Intron|ARFGAP2_ENST00000319543.6_Intron|ARFGAP2_ENST00000395449.3_5'UTR|ARFGAP2_ENST00000419701.2_Missense_Mutation_p.A11V	NM_001242832.1|NM_032389.4	NP_001229761.1|NP_115765.2	Q8N6H7	ARFG2_HUMAN	ADP-ribosylation factor GTPase activating protein 2	90	Arf-GAP.				protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						GCGAAAAAAAGCCGTCTGGAG	0.512000													35	65					0	0	1	0	0
TBX4	9496	broad.mit.edu	37	17	59560652	59560652	+	Silent	SNP	T	T	C			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr17:59560652T>C	ENST00000393853.4	+	9	1579	c.1416T>C	c.(1414-1416)ttT>ttC	p.F472F	TBX4_ENST00000589449.1_3'UTR|TBX4_ENST00000240335.1_Silent_p.F471F			P57082	TBX4_HUMAN	T-box 4	471					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(15)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						ATGCCCACTTTAGTGTCTACA	0.647000													15	51					0	0	1	0	0
TET1	80312	broad.mit.edu	37	10	70332828	70332828	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr10:70332828C>T	ENST00000373644.4	+	2	942	c.733C>T	c.(733-735)Cag>Tag	p.Q245*		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	245					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						AATGTTTGCTCAGGACACAGT	0.488000													28	46					0	0	1	0	0
COX5B	1329	broad.mit.edu	37	2	98264496	98264496	+	Silent	SNP	G	G	A			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr2:98264496G>A	ENST00000258424.2	+	4	362	c.315G>A	c.(313-315)ctG>ctA	p.L105L	COX5B_ENST00000464949.1_3'UTR	NM_001862.2	NP_001853.2	P10606	COX5B_HUMAN	cytochrome c oxidase subunit Vb	105					respiratory electron transport chain|respiratory gaseous exchange	mitochondrial inner membrane	cytochrome-c oxidase activity|metal ion binding			endometrium(1)|lung(1)|urinary_tract(1)	3						GGTTTTGGCTGCACAAAGGCG	0.507000													4	29					0	0	1	0	0
KIF4A	24137	broad.mit.edu	37	X	69572507	69572507	+	Splice_Site	SNP	G	G	A			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chrX:69572507G>A	ENST00000374403.3	+	14	1570		c.e14+1		KIF4A_ENST00000374388.3_Splice_Site	NM_012310.4	NP_036442.3	O95239	KIF4A_HUMAN	kinesin family member 4A						anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			breast(6)|endometrium(9)|kidney(3)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	51						GCAAGAAGCCGTAAGTAATTG	0.433000													4	52					0	0	1	0	0
TRMT2B	79979	broad.mit.edu	37	X	100277044	100277044	+	Missense_Mutation	SNP	A	A	G			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chrX:100277044A>G	ENST00000338687.7	-	8	1434	c.629T>C	c.(628-630)cTc>cCc	p.L210P	TRMT2B_ENST00000372931.5_Missense_Mutation_p.L255P|TRMT2B_ENST00000545398.1_Missense_Mutation_p.L255P|TRMT2B_ENST00000372935.1_Missense_Mutation_p.L255P|TRMT2B_ENST00000372936.3_Missense_Mutation_p.L255P|TRMT2B_ENST00000372939.1_Missense_Mutation_p.L210P			Q96GJ1	TRM2_HUMAN	tRNA methyltransferase 2 homolog B (S. cerevisiae)	255							tRNA (uracil-5-)-methyltransferase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	24						CTGAACATGGAGCTCCTCCTG	0.448000													5	55					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83127919	83127919	+	Missense_Mutation	SNP	A	A	G			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chrX:83127919A>G	ENST00000329312.4	+	4	240	c.203A>G	c.(202-204)gAa>gGa	p.E68G		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	68					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						AAACTAGAAGAAGGCCAGAAA	0.343000													15	21					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113532652	113532652	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr12:113532652G>A	ENST00000257600.3	+	6	1789	c.1286G>A	c.(1285-1287)cGg>cAg	p.R429Q	DTX1_ENST00000547974.1_3'UTR	NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	429					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						GGCGTGCTTCGGCACAAGGGC	0.652000													14	21					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													5	57					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76876000	76876000	+	Splice_Site	SNP	C	C	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chrX:76876000C>T	ENST00000373344.5	-	20	5349	c.5135G>A	c.(5134-5136)gGc>gAc	p.G1712D	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Splice_Site_p.G1674D	NM_000489.3	NP_000480.3	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1712	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	AAAATCAGGGCCTACAAAAAT	0.289000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						12	24					0	0	1	0	0
FAM196A	642938	broad.mit.edu	37	10	128974295	128974295	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr10:128974295C>T	ENST00000522781.1	-	4	920	c.365G>A	c.(364-366)cGc>cAc	p.R122H	FAM196A_ENST00000424811.2_Missense_Mutation_p.R122H|DOCK1_ENST00000280333.6_Intron	NM_001039762.2	NP_001034851.1	Q6ZSG2	F196A_HUMAN	family with sequence similarity 196, member A	122										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						CCCCTTTTTGCGGTCCAGAGG	0.547000													4	68					0	0	1	0	0
ZHX3	23051	broad.mit.edu	37	20	39831589	39831589	+	Silent	SNP	A	A	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr20:39831589A>T	ENST00000309060.3	-	4	2383	c.1968T>A	c.(1966-1968)atT>atA	p.I656I	ZHX3_ENST00000560361.1_Silent_p.I656I|ZHX3_ENST00000540170.1_Silent_p.I656I|ZHX3_ENST00000559234.1_Silent_p.I656I|ZHX3_ENST00000432768.2_Silent_p.I656I|ZHX3_ENST00000544979.2_Silent_p.I656I|ZHX3_ENST00000558993.1_Intron|ZHX3_ENST00000557816.1_Intron			Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	656					negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(5)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		Myeloproliferative disorder(115;0.00425)				ACCAGCTATCAATTTCTCGTC	0.502000													4	154					0	0	1	0	0
GNAT1	2779	broad.mit.edu	37	3	50230983	50230983	+	Silent	SNP	G	G	A			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr3:50230983G>A	ENST00000232461.3	+	4	450	c.336G>A	c.(334-336)gaG>gaA	p.E112E	GNAT1_ENST00000433068.1_Silent_p.E112E	NM_144499.2	NP_653082.1	P11488	GNAT1_HUMAN	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1	112					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|negative regulation of cyclic-nucleotide phosphodiesterase activity|rhodopsin mediated phototransduction|sensory perception of umami taste	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	acyl binding|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GDP binding|GTP binding|GTPase activity|protein kinase binding|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CTATCGAGGAGGGCACGATGC	0.652000													12	29					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								24	47					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30091799	30091799	+	RNA	SNP	A	A	G			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr18:30091799A>G	ENST00000567636.1	+	0	174					NR_003558.1																						ttAAATGAACAAGTAAACCAT	0.438000													22	52					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577108	7577108	+	Missense_Mutation	SNP	C	C	A			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr17:7577108C>A	ENST00000420246.2	-	8	962	c.830G>T	c.(829-831)tGt>tTt	p.C277F	TP53_ENST00000413465.2_Intron|TP53_ENST00000269305.4_Missense_Mutation_p.C277F|TP53_ENST00000445888.2_Missense_Mutation_p.C277F|TP53_ENST00000455263.2_Missense_Mutation_p.C277F|TP53_ENST00000359597.4_Missense_Mutation_p.C277F	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	277	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C277F(24)|p.C277Y(15)|p.0?(8)|p.?(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.A276_C277delAC(1)|p.F270_D281del12(1)|p.V274_P278del(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.C277S(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTCCCAGGACAGGCACAAAC	0.547000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	10					1.64113e-05	1.64113e-05	1	1	0
UGT8	7368	broad.mit.edu	37	4	115544143	115544143	+	Missense_Mutation	SNP	A	A	G			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr4:115544143A>G	ENST00000310836.6	+	2	629	c.107A>G	c.(106-108)tAc>tGc	p.Y36C	UGT8_ENST00000394511.3_Missense_Mutation_p.Y36C	NM_001128174.1	NP_001121646	Q16880	CGT_HUMAN	UDP glycosyltransferase 8	36					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		AGCCATATGTACATTTTCAAG	0.478000													16	30					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45833896	45833896	+	Missense_Mutation	SNP	C	C	G			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr21:45833896C>G	ENST00000397928.1	+	20	3530	c.3085C>G	c.(3085-3087)Ctc>Gtc	p.L1029V	TRPM2_ENST00000300481.9_Missense_Mutation_p.L1009V|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Missense_Mutation_p.L1029V|TRPM2_ENST00000397932.2_Missense_Mutation_p.L1029V	NM_003307.3	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1029						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GGTCCTCCTACTCTGCCTCTA	0.642000													6	262					0	0	1	0	0
SEPT6	23157	broad.mit.edu	37	X	118774726	118774726	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chrX:118774726C>T	ENST00000394610.1	-	6	980	c.716G>A	c.(715-717)gGc>gAc	p.G239D	SEPT6_ENST00000394617.2_Missense_Mutation_p.G269D|SEPT6_ENST00000489216.1_Missense_Mutation_p.G239D|SEPT6_ENST00000360156.7_Missense_Mutation_p.G239D|SEPT6_ENST00000343984.5_Missense_Mutation_p.G239D|SEPT6_ENST00000354416.3_Missense_Mutation_p.G239D|SEPT6_ENST00000394616.4_Missense_Mutation_p.G181D|SEPT6_ENST00000354228.4_Missense_Mutation_p.G239D	NM_145799.3	NP_665798.1	Q14141	SEPT6_HUMAN	septin 6	239					cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(3)	17						TTCTGTGCTGCCAATGACAGC	0.537000			T	MLL	AML								13	64					0	0	1	0	0
RNF216	54476	broad.mit.edu	37	7	5781284	5781284	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr7:5781284C>T	ENST00000389902.3	-	4	631	c.364G>A	c.(364-366)Ggg>Agg	p.G122R	RNF216_ENST00000425013.2_Intron			Q9NWF9	RN216_HUMAN	ring finger protein 216	65					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding		FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TCCTGTGCCCCAGAATCAAAC	0.433000													4	169					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107602687	107602687	+	Silent	SNP	G	G	A			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr9:107602687G>A	ENST00000374736.3	-	9	1321	c.927C>T	c.(925-927)tgC>tgT	p.C309C		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	309					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CGGGATGCCCGCAGACAATAC	0.532000													3	45					0	0	1	0	0
ZSCAN21	7589	broad.mit.edu	37	7	99661835	99661835	+	Missense_Mutation	SNP	A	A	G			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr7:99661835A>G	ENST00000543588.1	+	6	1158	c.914A>G	c.(913-915)aAg>aGg	p.K305R	ZSCAN21_ENST00000292450.4_Silent_p.K339K|ZSCAN21_ENST00000456748.2_Missense_Mutation_p.K305R|ZSCAN21_ENST00000477297.1_3'UTR|ZNF3_ENST00000413658.2_3'UTR			Q9Y5A6	ZSC21_HUMAN	zinc finger and SCAN domain containing 21	0					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|skin(1)	21	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			AGTGTGGAAAAGCTTTTGGGC	0.502000													29	48					0	0	1	0	0
LOC146880	146880	broad.mit.edu	37	17	62758555	62758555	+	RNA	SNP	T	T	C			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr17:62758555T>C	ENST00000400873.3	-	0	1390					NR_026899.1																						AGAGTAGATATGGTAAGAACT	0.433000													14	29					0	0	1	0	0
OR13C3	138803	broad.mit.edu	37	9	107298302	107298302	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr9:107298302G>A	ENST00000374781.2	-	1	835	c.793C>T	c.(793-795)Cgc>Tgc	p.R265C		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	265					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						AATGCCTTGCGTCTTCCTGTG	0.428000													19	73					0	0	1	0	0
ASZ1	136991	broad.mit.edu	37	7	117003694	117003694	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr7:117003694C>T	ENST00000284629.2	-	13	1446	c.1384G>A	c.(1384-1386)Ggt>Agt	p.G462S		NM_130768.2	NP_570124.1	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper domain containing 1	462					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(3)|skin(1)	24	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			AGAAGAAAACCGAATCCGCAT	0.318000													32	74					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	62					0	0	1	0	0
ZFYVE20	64145	broad.mit.edu	37	3	15126301	15126301	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr3:15126301C>T	ENST00000253699.3	-	8	1152	c.539G>A	c.(538-540)cGc>cAc	p.R180H	ZFYVE20_ENST00000449964.2_5'UTR|ZFYVE20_ENST00000435849.3_Missense_Mutation_p.R180H|ZFYVE20_ENST00000476527.2_Missense_Mutation_p.R180H	NM_022340.2	NP_071735.2	Q9H1K0	RBNS5_HUMAN	zinc finger, FYVE domain containing 20	180	Necessary for the correct targeting to endosomes.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|skin(3)|stomach(1)|urinary_tract(2)	26						CCCGCAGAGGCGGCAGTGGTG	0.547000													4	67					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24909113	24909113	+	Nonsense_Mutation	SNP	G	G	A	rs139365604		TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr10:24909113G>A	ENST00000396432.2	-	9	2197	c.1711C>T	c.(1711-1713)Cga>Tga	p.R571*	ARHGAP21_ENST00000320481.6_Nonsense_Mutation_p.R358*	NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	570					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						CCACTCATTCGCCTGTTATCA	0.393000													7	167					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998604	27998604	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chrX:27998604G>A	ENST00000441525.1	-	1	962	c.848C>T	c.(847-849)gCc>gTc	p.A283V		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	283										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						CCTGTGCTTGGCCACACGCTT	0.507000													24	48					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39823120	39823120	+	Missense_Mutation	SNP	A	A	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr1:39823120A>T	ENST00000564288.1	+	45	12275	c.11498A>T	c.(11497-11499)gAt>gTt	p.D3833V	MACF1_ENST00000539005.1_Missense_Mutation_p.D1771V|MACF1_ENST00000567887.1_Missense_Mutation_p.D3870V|MACF1_ENST00000361689.2_Missense_Mutation_p.D1771V|MACF1_ENST00000476350.1_3'UTR|MACF1_ENST00000545844.1_Missense_Mutation_p.D1771V|MACF1_ENST00000372915.3_Missense_Mutation_p.D3838V|MACF1_ENST00000317713.7_Missense_Mutation_p.D1771V|MACF1_ENST00000289893.4_Missense_Mutation_p.D2273V			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	3838					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GCCTTCTTGGATCAGCATGGC	0.502000													4	52					0	0	1	0	0
TMEM45A	55076	broad.mit.edu	37	3	100274191	100274191	+	Missense_Mutation	SNP	T	T	G			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr3:100274191T>G	ENST00000403410.1	+	4	804	c.184T>G	c.(184-186)Ttc>Gtc	p.F62V	TMEM45A_ENST00000323523.4_Missense_Mutation_p.F46V|TMEM45A_ENST00000462884.1_3'UTR			Q9NWC5	TM45A_HUMAN	transmembrane protein 45A	46						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)	11						CAAAACATTATTCTATCGATT	0.353000													3	99					0	0	1	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60242148	60242148	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr18:60242148C>T	ENST00000269499.5	+	13	3252	c.2834C>T	c.(2833-2835)cCa>cTa	p.P945L	ZCCHC2_ENST00000586834.1_Missense_Mutation_p.P624L	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	945					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						TCTCCCCAGCCAGCGAGCGCA	0.642000													24	43					0	0	1	0	0
CA8	767	broad.mit.edu	37	8	61121347	61121347	+	Silent	SNP	C	C	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr8:61121347C>T	ENST00000317995.4	-	8	1134	c.870G>A	c.(868-870)caG>caA	p.Q290Q		NM_004056.4	NP_004047.3	P35219	CAH8_HUMAN	carbonic anhydrase VIII	290					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding			endometrium(2)|large_intestine(5)|lung(6)|prostate(2)|skin(1)	16		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)				TCTTTGGCTACTGAAATGCAG	0.468000													22	60					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83128300	83128300	+	Missense_Mutation	SNP	G	G	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chrX:83128300G>T	ENST00000329312.4	+	4	621	c.584G>T	c.(583-585)tGt>tTt	p.C195F		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	195					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						TCAAAAAATTGTTCACAAAAA	0.318000													15	40					7.93312e-07	8.09839e-07	1	1	0
ARSD	414	broad.mit.edu	37	X	2836162	2836162	+	Silent	SNP	G	G	A			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chrX:2836162G>A	ENST00000381154.1	-	5	621	c.546C>T	c.(544-546)aaC>aaT	p.N182N	ARSD_ENST00000217890.6_5'UTR	NM_001669.3	NP_001660.2	P51689	ARSD_HUMAN	arylsulfatase D	182						lysosome	arylsulfatase activity|metal ion binding			large_intestine(3)|lung(3)	6		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGTCACAGTCGTTTGTGAGCG	0.632000													9	7					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173526585	173526585	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr1:173526585C>T	ENST00000367714.3	-	10	1531	c.1109G>A	c.(1108-1110)cGa>cAa	p.R370Q	SLC9C2_ENST00000466087.1_5'UTR|RP3-436N22.3_ENST00000431459.1_RNA|SLC9C2_ENST00000536496.1_Missense_Mutation_p.R268Q	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	370					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										AACTCCCCATCGCCAATTATA	0.368000													45	104					0	0	1	0	0
MEST	4232	broad.mit.edu	37	7	130138088	130138088	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr7:130138088G>A	ENST00000223215.4	+	5	669	c.448G>A	c.(448-450)Gat>Aat	p.D150N	MEST_ENST00000416162.2_Missense_Mutation_p.D141N|hsa-mir-335_ENST00000604666.1_RNA|MEST_ENST00000393187.1_Missense_Mutation_p.D141N|MEST_ENST00000437945.1_Missense_Mutation_p.D150N|MEST_ENST00000341441.5_Missense_Mutation_p.D141N|MEST_ENST00000378576.4_Missense_Mutation_p.D141N|MEST_ENST00000462132.1_3'UTR	NM_001253900.1|NM_002402.3	NP_001240829.1|NP_002393.2	Q5EB52	MEST_HUMAN	mesoderm specific transcript	150					mesoderm development	endoplasmic reticulum membrane|integral to membrane	hydrolase activity|protein binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(2)	12	Melanoma(18;0.0435)					TGACTATGGAGATATTGTTGC	0.463000													28	52					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62818136	62818136	+	RNA	SNP	G	G	C			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr17:62818136G>C	ENST00000582986.1	-	0	362					NR_024386.1																						CTGAAGAATGGGAAATGGAAT	0.572000													6	32					0	0	1	0	0
SLC27A3	11000	broad.mit.edu	37	1	153748614	153748615	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr1:153748614_153748615delGC	ENST00000271857.2	+	1	1785_1786	c.1025_1026delGC	c.(1024-1026)ggcfs	p.G342fs	SLC27A3_ENST00000484014.1_3'UTR|SLC27A3_ENST00000368661.3_Frame_Shift_Del_p.G261fs			Q5K4L6	S27A3_HUMAN	solute carrier family 27 (fatty acid transporter), member 3	261					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			NS(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	14	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CGCAGCTGCGGCGCGCGCGCGC	0.718													2	4	---	---	---	---					
SPON1	10418	broad.mit.edu	37	11	14096906	14096906	+	RNA	DEL	A	A	-			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr11:14096906delA	ENST00000310358.7	+	0	1032							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		AGCATCGTACAAAAACGCATT	0.517													2	4	---	---	---	---					
TMOD2	29767	broad.mit.edu	37	15	52060571	52060574	+	Frame_Shift_Del	DEL	AGAA	AGAA	-			TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr15:52060571_52060574delAGAA	ENST00000249700.4	+	3	460_463	c.239_242delAGAA	c.(238-243)cagaaafs	p.QK80fs	TMOD2_ENST00000435126.2_Frame_Shift_Del_p.QK80fs|TMOD2_ENST00000539962.2_Frame_Shift_Del_p.QK36fs	NM_001142885.1|NM_014548.3	NP_001136357.1|NP_055363.1	Q9NZR1	TMOD2_HUMAN	tropomodulin 2 (neuronal)	80					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	16				all cancers(107;0.00435)		GCTTTGGAACAGAAAGACAGAGAG	0.505													9	48	---	---	---	---					
NPIPB1P	729602	broad.mit.edu	37	18	11625378	11625379	+	RNA	INS	-	-	A	rs141097667		TCGA-E1-A7YH-01A-11D-A34A-08	TCGA-E1-A7YH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7bd016e-062a-49f1-8294-8fcb32b15cb0	22ba3a91-d5b4-4dde-a2cf-84830a225008	g.chr18:11625378_11625379insA	ENST00000547442.1	-	0	621																											CTCTTCCCCCGAAAAATGACAA	0.401													2	4	---	---	---	---					
