Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FGFBP1	9982	broad.mit.edu	37	4	15938242	15938242	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr4:15938242C>T	ENST00000382333.1	-	3	308	c.14G>A	c.(13-15)aGc>aAc	p.S5N	FGFBP1_ENST00000259988.2_Missense_Mutation_p.S5N	NM_005130.4	NP_005121.1	Q14512	FGFP1_HUMAN	fibroblast growth factor binding protein 1	5					cell-cell signaling|negative regulation of cell proliferation|signal transduction	extracellular space|plasma membrane	heparin binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(2)|prostate(2)|skin(1)	10						CAGGGTGAGGCTACAGATCTT	0.537000													26	42					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15813153	15813153	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr16:15813153C>T	ENST00000452625.2	-	37	5203	c.5116G>A	c.(5116-5118)Gct>Act	p.A1706T	NDE1_ENST00000342673.5_Intron|NDE1_ENST00000396355.1_Intron|MYH11_ENST00000576790.2_Missense_Mutation_p.A1699T|MYH11_ENST00000300036.5_Missense_Mutation_p.A1699T|NDE1_ENST00000396354.1_Intron|MYH11_ENST00000396324.3_Missense_Mutation_p.A1706T	NM_001040113.1	NP_001035202.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1699					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						GCCCTCTCAGCGGCGGCGAGG	0.602000			T	CBFB	AML								3	27					0	0	1	0	0
PRDM15	63977	broad.mit.edu	37	21	43274913	43274913	+	Silent	SNP	G	G	A			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr21:43274913G>A	ENST00000422911.1	-	5	512	c.411C>T	c.(409-411)gaC>gaT	p.D137D	PRDM15_ENST00000538201.1_Silent_p.D100D|PRDM15_ENST00000398548.1_Silent_p.D137D|PRDM15_ENST00000447207.2_Silent_p.D100D|PRDM15_ENST00000269844.3_Silent_p.D466D	NM_001282934.1	NP_001269863.1	P57071	PRD15_HUMAN	PR domain containing 15	466					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						CGGGGTGCCCGTCCTTCTGGA	0.622000													13	42					0	0	1	0	0
GDPGP1	390637	broad.mit.edu	37	15	90784327	90784327	+	Missense_Mutation	SNP	C	C	G			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr15:90784327C>G	ENST00000558017.1	+	4	607	c.187C>G	c.(187-189)Ctc>Gtc	p.L63V	GDPGP1_ENST00000329600.6_Missense_Mutation_p.L63V	NM_001013657.2	NP_001013679.2	Q6ZNW5	VTC2_HUMAN	GDP-D-glucose phosphorylase 1	63					glucose metabolic process	cytoplasm	GDP-D-glucose phosphorylase activity										TGATGCTGCACTCTGCTCTGC	0.572000													38	117					0	0	1	0	0
THBS2	7058	broad.mit.edu	37	6	169648831	169648831	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr6:169648831C>T	ENST00000366787.3	-	4	539	c.290G>A	c.(289-291)aGg>aAg	p.R97K		NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	97	Heparin-binding (Potential).|TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CAGCGTGCCCCTGGACTTGCC	0.622000													21	81					0	0	1	0	0
AGAP10	728127	broad.mit.edu	37	10	47207813	47207813	+	Splice_Site	SNP	T	T	C			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr10:47207813T>C	ENST00000355232.3	-	5	3482	c.470A>G	c.(469-471)cAt>cGt	p.H157R	AGAP10_ENST00000413193.2_Splice_Site_p.H228R|RP11-144G6.12_ENST00000605970.1_RNA|AGAP10_ENST00000452145.2_Splice_Site_p.H132R					ArfGAP with GTPase domain, ankyrin repeat and PH domain 10									p.H228R(20)		endometrium(5)|kidney(3)|lung(1)|prostate(2)|urinary_tract(1)	12						TTTACTTACATGGTTTGTACA	0.294000													3	33					0	0	1	0	0
FABP6	2172	broad.mit.edu	37	5	159656578	159656578	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr5:159656578G>A	ENST00000393980.4	+	4	307	c.161G>A	c.(160-162)gGc>gAc	p.G54D	FABP6_ENST00000393982.1_Missense_Mutation_p.G54D|FABP6_ENST00000402432.3_Missense_Mutation_p.G5D	NM_001130958.1	NP_001124430.1	P51161	FABP6_HUMAN	fatty acid binding protein 6, ileal	5					bile acid and bile salt transport|bile acid metabolic process|negative regulation of cell proliferation	cytosol	transporter activity	p.G54D(1)|p.G5D(1)		breast(1)|kidney(1)|large_intestine(1)|lung(2)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCTTTCACCGGCAAGTTCGAG	0.537000													4	175					0	0	1	0	0
SERPINA11	256394	broad.mit.edu	37	14	94914772	94914772	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr14:94914772C>T	ENST00000334708.3	-	2	404	c.340G>A	c.(340-342)Gac>Aac	p.D114N	RP11-349I1.2_ENST00000536735.1_RNA	NM_001080451.1	NP_001073920.1	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	114					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(14)|skin(1)|upper_aerodigestive_tract(1)	24				COAD - Colon adenocarcinoma(157;0.211)		TGGTGGATGTCGGCTTCAGGG	0.592000													4	175					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50346470	50346470	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr20:50346470C>T	ENST00000338821.5	-	2	380	c.116G>A	c.(115-117)cGc>cAc	p.R39H	ATP9A_ENST00000477492.1_5'UTR|ATP9A_ENST00000311637.5_Missense_Mutation_p.R24H|ATP9A_ENST00000402822.1_Missense_Mutation_p.R39H	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	39					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						CCAGACAGTGCGGGGCCTGGC	0.587000													4	145					0	0	1	0	0
AMIGO2	347902	broad.mit.edu	37	12	47472572	47472572	+	Missense_Mutation	SNP	T	T	C			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr12:47472572T>C	ENST00000266581.4	-	2	680	c.214A>G	c.(214-216)Aga>Gga	p.R72G	AMIGO2_ENST00000429635.1_Missense_Mutation_p.R72G|AMIGO2_ENST00000321382.3_Missense_Mutation_p.R72G|AMIGO2_ENST00000550413.1_Missense_Mutation_p.R72G	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	72					heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					AGGTCCAGTCTCTTAATCAGT	0.478000													22	80					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725644	140725644	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr5:140725644G>A	ENST00000253812.6	+	1	2044	c.2044G>A	c.(2044-2046)Gcc>Acc	p.A682T	PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGAGCCCTCCGCCAAACCCAA	0.687000													4	123					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3499331	3499331	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr18:3499331C>T	ENST00000315677.3	-	13	3381	c.2786G>A	c.(2785-2787)cGg>cAg	p.R929Q	DLGAP1_ENST00000400149.3_Missense_Mutation_p.R619Q|DLGAP1_ENST00000534970.1_Missense_Mutation_p.R613Q|DLGAP1_ENST00000400150.3_Missense_Mutation_p.R645Q|DLGAP1_ENST00000400147.2_Missense_Mutation_p.R627Q|DLGAP1_ENST00000584874.1_Missense_Mutation_p.R929Q|DLGAP1_ENST00000400155.1_Missense_Mutation_p.R635Q|DLGAP1_ENST00000539435.1_Missense_Mutation_p.R637Q|DLGAP1_ENST00000581699.1_Missense_Mutation_p.R635Q	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	929					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				CGAGCGCTCCCGGATCAGCGG	0.677000													3	3					0	0	1	0	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													6	132					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140626622	140626622	+	Silent	SNP	G	G	A			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr5:140626622G>A	ENST00000231173.3	+	1	1476	c.1476G>A	c.(1474-1476)ccG>ccA	p.P492P		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		492	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCTGCTGCCGCCCCGGGACC	0.667000													59	157					0	0	1	0	0
SERPINA6	866	broad.mit.edu	37	14	94780585	94780585	+	Missense_Mutation	SNP	T	T	C			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr14:94780585T>C	ENST00000341584.3	-	2	547	c.401A>G	c.(400-402)gAt>gGt	p.D134G		NM_001756.3	NP_001747	P08185	CBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	134					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	26		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	CAGGCTGCCATCAAGAAACAA	0.502000													11	61					0	0	1	0	0
ZNF689	115509	broad.mit.edu	37	16	30616551	30616551	+	Missense_Mutation	SNP	G	G	C			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr16:30616551G>C	ENST00000287461.3	-	3	874	c.537C>G	c.(535-537)tgC>tgG	p.C179W	ZNF689_ENST00000566673.1_5'UTR|RP11-146F11.5_ENST00000563540.1_RNA	NM_138447.1	NP_612456.1	Q96CS4	ZN689_HUMAN	zinc finger protein 689	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(1)	14			Colorectal(24;0.198)			CACAGTCTGGGCAAGGGTAAG	0.612000													21	90					0	0	1	0	0
SHB	6461	broad.mit.edu	37	9	38016073	38016073	+	Missense_Mutation	SNP	C	C	G			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr9:38016073C>G	ENST00000377707.3	-	2	1338	c.773G>C	c.(772-774)aGc>aCc	p.S258T	SHB_ENST00000377700.4_Missense_Mutation_p.S258T|RP11-613M10.9_ENST00000540557.1_Missense_Mutation_p.S258T	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	258	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		TCCTGCTTTGCTCTTGAGATC	0.537000													34	121					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								23	42					0	0	1	0	0
PTPRM	5797	broad.mit.edu	37	18	8379324	8379324	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr18:8379324G>A	ENST00000332175.8	+	26	4770	c.3733G>A	c.(3733-3735)Gct>Act	p.A1245T	PTPRM_ENST00000400053.4_Missense_Mutation_p.A1183T|PTPRM_ENST00000444013.1_Missense_Mutation_p.A1032T|PTPRM_ENST00000400060.4_Missense_Mutation_p.A1259T|PTPRM_ENST00000580170.1_Missense_Mutation_p.A1258T	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1245	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				CTACATCAATGCTGCCCTCAT	0.607000													26	41					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43403589	43403589	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr6:43403589G>A	ENST00000244533.3	+	3	1939	c.1580G>A	c.(1579-1581)cGg>cAg	p.R527Q	ABCC10_ENST00000372530.4_Missense_Mutation_p.R570Q	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	570	ABC transmembrane type-1 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.R527Q(2)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TCCTTGGACCGGATCCAGCTT	0.567000													21	76					0	0	1	0	0
FAM66D	100132923	broad.mit.edu	37	8	11986016	11986016	+	RNA	SNP	C	C	A			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr8:11986016C>A	ENST00000434078.2	+	0	608					NR_027425.1																						AACGTCTTGGCGGCAGGCGCC	0.478000													4	20					0.00024832	0.00024832	1	1	0
KIF16B	55614	broad.mit.edu	37	20	16359697	16359697	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr20:16359697C>A	ENST00000354981.2	-	19	3107	c.2950G>T	c.(2950-2952)Gaa>Taa	p.E984*	KIF16B_ENST00000378003.2_Nonsense_Mutation_p.E210*|KIF16B_ENST00000355755.3_Nonsense_Mutation_p.E984*|KIF16B_ENST00000408042.1_Nonsense_Mutation_p.E984*	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	984	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity	p.E984K(2)|p.E984*(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						CTCACTTTTTCCTCCTGACGT	0.512000													61	110					2.14255e-21	2.24706e-21	1	1	0
SPEN	23013	broad.mit.edu	37	1	16262471	16262471	+	Missense_Mutation	SNP	A	A	C			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr1:16262471A>C	ENST00000375759.3	+	11	9940	c.9736A>C	c.(9736-9738)Acc>Ccc	p.T3246P		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	3246	Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ccccacccccacccctgcccc	0.662000													4	10					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14965518	14965518	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr3:14965518G>A	ENST00000285046.5	+	17	4051	c.3941G>A	c.(3940-3942)cGg>cAg	p.R1314Q	FGD5_ENST00000476851.1_3'UTR|FGD5_ENST00000543601.1_Missense_Mutation_p.R1073Q|FGD5-AS1_ENST00000430166.1_RNA	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1314					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						GTTACAGAGCGGCCTGTGAGC	0.537000													20	35					0	0	1	0	0
KLHL25	64410	broad.mit.edu	37	15	86312002	86312002	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr15:86312002C>T	ENST00000337975.5	-	2	1314	c.1040G>A	c.(1039-1041)gGc>gAc	p.G347D	KLHL25_ENST00000536947.1_Missense_Mutation_p.G347D|KLHL25_ENST00000559131.1_Intron	NM_022480.3	NP_071925.2	Q9H0H3	ENC2_HUMAN	kelch-like family member 25	347						cytoplasm				breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	25						GGAGCCCCTGCCCCCCGTCAC	0.637000													3	37					0	0	1	0	0
ECM1	1893	broad.mit.edu	37	1	150482462	150482462	+	Silent	SNP	C	C	A			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr1:150482462C>A	ENST00000369047.4	+	4	413	c.288C>A	c.(286-288)ctC>ctA	p.L96L	ECM1_ENST00000346569.6_Silent_p.L96L|ECM1_ENST00000369049.4_Silent_p.L123L|ECM1_ENST00000470432.1_3'UTR	NM_004425.3	NP_004416.2	Q16610	ECM1_HUMAN	extracellular matrix protein 1	96					angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|urinary_tract(1)	22	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTGCCCAACTCCCTGCTGAAA	0.592000													28	87					1.16021e-09	1.18783e-09	1	1	0
DKC1	1736	broad.mit.edu	37	X	153994501	153994501	+	Missense_Mutation	SNP	A	A	C			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chrX:153994501A>C	ENST00000369550.5	+	5	484	c.274A>C	c.(274-276)Att>Ctt	p.I92L		NM_001142463.1|NM_001363.3	NP_001135935.1|NP_001354.1	O60832	DKC1_HUMAN	dyskeratosis congenita 1, dyskerin	92					cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity			breast(2)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)	15	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GACAGGTTTCATTAATCTTGA	0.413000									Congenital Dyskeratosis				4	107					0	0	1	0	0
ATP2A3	489	broad.mit.edu	37	17	3844416	3844416	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr17:3844416C>T	ENST00000309890.7	-	14	2099	c.1949G>A	c.(1948-1950)gGc>gAc	p.G650D	ATP2A3_ENST00000397043.3_Missense_Mutation_p.G650D|ATP2A3_ENST00000397041.3_Missense_Mutation_p.G650D|ATP2A3_ENST00000359983.3_Missense_Mutation_p.G650D|ATP2A3_ENST00000397035.3_Missense_Mutation_p.G650D|ATP2A3_ENST00000397039.1_5'UTR|ATP2A3_ENST00000352011.3_Missense_Mutation_p.G650D	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	650					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GTAGGCCTTGCCCGCCACGTC	0.687000													4	76					0	0	1	0	0
KRT71	112802	broad.mit.edu	37	12	52940220	52940220	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr12:52940220G>A	ENST00000267119.5	-	7	1244	c.1175C>T	c.(1174-1176)gCc>gTc	p.A392V		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	392	Coil 2.|Rod.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		GTCCAGCTTGGCCCGGGCATC	0.622000													19	50					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44803600	44803600	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr20:44803600G>A	ENST00000372262.3	-	11	2432	c.2032C>T	c.(2032-2034)Cag>Tag	p.Q678*	CDH22_ENST00000537909.1_Nonsense_Mutation_p.Q678*	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	678					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				TCGGTGTCCTGCTCGCCGCCG	0.677000													13	33					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10428846	10428846	+	Missense_Mutation	SNP	G	G	C			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr17:10428846G>C	ENST00000245503.5	-	32	4843	c.4459C>G	c.(4459-4461)Ctg>Gtg	p.L1487V	RP11-799N11.1_ENST00000399342.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA|MYH2_ENST00000532183.2_Intron|MYH2_ENST00000397183.2_Missense_Mutation_p.L1487V|CTC-297N7.11_ENST00000587182.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1487					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						ATCTTGAACAGCTCAGTGCCA	0.458000													17	61					0	0	1	0	0
ZFP69B	65243	broad.mit.edu	37	1	40929203	40929203	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr1:40929203C>T	ENST00000411995.2	+	6	1922	c.1547C>T	c.(1546-1548)tCa>tTa	p.S516L	ZFP69B_ENST00000361584.3_Missense_Mutation_p.S414L|ZFP69B_ENST00000484445.1_3'UTR	NM_023070.2	NP_075558.2			ZFP69 zinc finger protein B																		AGCTGTAGTTCATCCCTTATT	0.353000													17	66					0	0	1	0	0
AP3M1	26985	broad.mit.edu	37	10	75893895	75893895	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr10:75893895G>A	ENST00000355264.4	-	4	784	c.473C>T	c.(472-474)cCc>cTc	p.P158L	AP3M1_ENST00000372745.1_Missense_Mutation_p.P158L	NM_012095.4	NP_036227.1	Q9Y2T2	AP3M1_HUMAN	adaptor-related protein complex 3, mu 1 subunit	158					protein targeting to lysosome|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus|lysosome	protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(1)|prostate(1)|skin(1)	13	Prostate(51;0.0112)					CTGCCCGGTGGGGAGTGTGTC	0.408000													10	54					0	0	1	0	0
MAPK8IP2	23542	broad.mit.edu	37	22	51041583	51041583	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr22:51041583C>T	ENST00000008876.5	+	1	22	c.22C>T	c.(22-24)Cct>Tct	p.P8S	MAPK8IP2_ENST00000399908.2_5'UTR|MAPK8IP2_ENST00000329492.3_Intron|MAPK8IP2_ENST00000442429.2_Intron|MAPK8IP2_ENST00000399912.1_Intron|MAPK8IP2_ENST00000341339.4_Intron			Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting protein 2	422					behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TTTCCCTTCTCCTAGCACCTG	0.617000													10	18					0	0	1	0	0
HERC5	51191	broad.mit.edu	37	4	89407330	89407330	+	Missense_Mutation	SNP	T	T	C			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr4:89407330T>C	ENST00000264350.3	+	14	1955	c.1802T>C	c.(1801-1803)cTc>cCc	p.L601P	HERC5_ENST00000508159.1_Missense_Mutation_p.L239P	NM_016323.3	NP_057407.2	Q9UII4	HERC5_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 5	601					innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			NS(2)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|liver(2)|lung(17)|ovary(4)|prostate(1)|skin(4)	53		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		TTGCACCGTCTCAATTTTTTT	0.333000													4	93					0	0	1	0	0
LIPG	9388	broad.mit.edu	37	18	47095873	47095873	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr18:47095873G>A	ENST00000261292.4	+	4	804	c.526G>A	c.(526-528)Ggg>Agg	p.G176R	LIPG_ENST00000577628.1_Missense_Mutation_p.G212R|LIPG_ENST00000580036.1_Missense_Mutation_p.G176R|LIPG_ENST00000427224.2_Missense_Mutation_p.G176R	NM_006033.2	NP_006024.1	Q9Y5X9	LIPE_HUMAN	lipase, endothelial	176					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(2)	18						GCACGTGGCCGGGTATGCAGG	0.542000													13	39					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27059244	27059245	+	Frame_Shift_Ins	INS	-	-	ATGA			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr1:27059244_27059245insATGA	ENST00000324856.7	+	4	2252_2253	c.1881_1882insATGA	c.(1882-1884)atgfs	p.-629fs	ARID1A_ENST00000457599.2_Frame_Shift_Ins_p.-629fs|ARID1A_ENST00000374152.2_Frame_Shift_Ins_p.-246fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)						androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.D627fs*2(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGCAAGAAGATATGAACCTGAG	0.475			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								7	122	---	---	---	---					
MAP3K9	4293	broad.mit.edu	37	14	71275774	71275776	+	In_Frame_Del	DEL	CCT	CCT	-	rs3832971		TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr14:71275774_71275776delCCT	ENST00000554752.2	-	1	112_114	c.113_115delAGG	c.(112-117)gaggcg>gcg	p.E38del	MAP3K9_ENST00000555993.2_In_Frame_Del_p.E38del|MAP3K9_ENST00000381250.4_In_Frame_Del_p.E38del	NM_001284230.1	NP_001271159.1	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	38	Ala-rich.|Poly-Glu.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity	p.E38delE(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		GCCGCCGCCGcctcctcctcctc	0.773													3	5	---	---	---	---					
PKD1L2	114780	broad.mit.edu	37	16	81183625	81183626	+	RNA	DEL	TT	TT	-	rs11296516		TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr16:81183625_81183626delTT	ENST00000533478.1	-	0	2609				PKD1L2_ENST00000525539.1_RNA	NM_001278425.1	NP_001265354.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TTGTTCACACtttttttttttt	0.465													2	4	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7576926	7576937	+	Splice_Site	DEL	GCTAGGAAAGAG	GCTAGGAAAGAG	-	rs34361146	byFrequency	TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr17:7576926_7576937delGCTAGGAAAGAG	ENST00000420246.2	-	9	1052	c.920delCTCTTTCCTAGC	c.(919-921)gct>gt	p.A307del	TP53_ENST00000269305.4_Splice_Site_p.A307del|TP53_ENST00000359597.4_Splice_Site_p.A307del|TP53_ENST00000445888.2_Splice_Site_p.A307del|TP53_ENST00000455263.2_Splice_Site_p.A307del|TP53_ENST00000413465.2_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	307	Interaction with CARM1.|Interaction with HIPK1 (By similarity).		A -> P (in a sporadic cancer; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(47)|p.0?(8)|p.A307fs*34(1)|p.L308fs*31(1)|p.A307V(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTGGGCAGTGCTAGGAAAGAGGCAAGGAAAG	0.500		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			44	55	---	---	---	---					
CENPB	1059	broad.mit.edu	37	20	3766523	3766524	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FG-A60L-01A-12D-A31L-08	TCGA-FG-A60L-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b315c7cc-b490-4aa8-93fa-d1e4c22ee6d6	ef593f3e-ebd2-4723-83fa-f98618aa0194	g.chr20:3766523_3766524insT	ENST00000379751.4	-	1	813_814	c.607_608insA	c.(607-609)ttcfs	p.F203fs		NM_001810.5	NP_001801.1	P07199	CENPB_HUMAN	centromere protein B, 80kDa	203					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding			kidney(1)|large_intestine(2)|lung(4)|skin(1)	8						GTCGGGCAGGAAGTCGTACCAT	0.708													51	101	---	---	---	---					
