Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GPBP1	65056	broad.mit.edu	37	5	56542308	56542308	+	Silent	SNP	A	A	G			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr5:56542308A>G	ENST00000424459.3	+	8	1994	c.720A>G	c.(718-720)acA>acG	p.T240T	GPBP1_ENST00000514387.2_Silent_p.T49T|GPBP1_ENST00000538707.1_Silent_p.T227T|GPBP1_ENST00000511209.1_Silent_p.T227T|GPBP1_ENST00000264779.6_Silent_p.T227T|GPBP1_ENST00000454432.2_Silent_p.T240T|GPBP1_ENST00000506184.2_Silent_p.T220T	NM_022913.3	NP_075064.1	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1	220					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	19		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)		CTCCACCTACAAAAGTAAGTT	0.373000													18	39					0	0	1	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													7	144					0	0	1	0	0
BIN2	51411	broad.mit.edu	37	12	51717863	51717863	+	Silent	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr12:51717863G>A	ENST00000267012.4	-	1	85	c.24C>T	c.(22-24)ggC>ggT	p.G8G	BIN2_ENST00000603260.1_5'UTR|BIN2_ENST00000604560.1_Silent_p.G8G|BIN2_ENST00000544402.1_Intron|BIN2_ENST00000452142.2_Silent_p.G8G	NM_016293.2	NP_057377.2	Q9UBW5	BIN2_HUMAN	bridging integrator 2	8						cytoplasm	protein binding			NS(2)|breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(3)	31						GGCCGGCCGCGCCGCCTGCCT	0.706000													28	71					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71347070	71347070	+	Silent	SNP	A	A	G			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr4:71347070A>G	ENST00000413702.1	+	4	897	c.609A>G	c.(607-609)ccA>ccG	p.P203P	MUC7_ENST00000304887.5_Silent_p.P203P|MUC7_ENST00000456088.1_Silent_p.P203P	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	203	Thr-rich.					extracellular region	protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			AAGCTCCACCATCTTCCTCAG	0.587000													5	217					0	0	1	0	0
SLC6A8	6535	broad.mit.edu	37	X	152960346	152960346	+	Splice_Site	SNP	T	T	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chrX:152960346T>A	ENST00000253122.5	+	12	2243		c.e12+2		SLC6A8_ENST00000430077.2_Splice_Site|SLC6A8_ENST00000485324.1_Splice_Site	NM_001142805.1|NM_005629.3	NP_001136277.1|NP_005620.1	P48029	SC6A8_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 8						creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	13	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	ATGGCTGAGGTAAGGCTCCCG	0.692000													7	9					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30053922	30053922	+	Missense_Mutation	SNP	C	C	G			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr15:30053922C>G	ENST00000346128.6	-	7	1218	c.744G>C	c.(742-744)ttG>ttC	p.L248F	TJP1_ENST00000356107.6_Missense_Mutation_p.L248F|TJP1_ENST00000400011.2_Missense_Mutation_p.L252F|TJP1_ENST00000495972.2_Missense_Mutation_p.L248F|TJP1_ENST00000545208.2_Missense_Mutation_p.L248F	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	248	PDZ 2.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		ACCTTTCTATCAATGTCTTTG	0.338000													31	53					0	0	1	0	0
FAM66D	100132923	broad.mit.edu	37	8	11986719	11986719	+	RNA	SNP	G	G	C			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr8:11986719G>C	ENST00000434078.2	+	0	608					NR_027425.1																						TGGATTTCAGGAAAAGCTGCA	0.522000													4	63					0	0	1	0	0
RXRA	6256	broad.mit.edu	37	9	137309089	137309089	+	Silent	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr9:137309089G>A	ENST00000540193.1	+	4	1328	c.405G>A	c.(403-405)gtG>gtA	p.V135V	RXRA_ENST00000356384.4_3'UTR|RXRA_ENST00000481739.1_Silent_p.V232V			P19793	RXRA_HUMAN	retinoid X receptor, alpha	232					cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	ACATGCCGGTGGAGAGGATCC	0.647000													39	78					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													3	45					0	0	1	0	0
GRHL3	57822	broad.mit.edu	37	1	24663605	24663605	+	Missense_Mutation	SNP	A	A	G			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr1:24663605A>G	ENST00000361548.4	+	5	880	c.650A>G	c.(649-651)gAa>gGa	p.E217G	GRHL3_ENST00000342072.4_Missense_Mutation_p.E124G|GRHL3_ENST00000236255.4_Missense_Mutation_p.E222G|GRHL3_ENST00000350501.5_Missense_Mutation_p.E217G|GRHL3_ENST00000356046.2_Missense_Mutation_p.E171G	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	217					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		ACCTCCCCGGAACCCCCATGT	0.567000													32	77					0	0	1	0	0
RIPK4	54101	broad.mit.edu	37	21	43161696	43161696	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr21:43161696C>T	ENST00000352483.2	-	9	1865	c.1801G>A	c.(1801-1803)Gtg>Atg	p.V601M	RIPK4_ENST00000544709.1_Missense_Mutation_p.V490M|RIPK4_ENST00000542057.1_Missense_Mutation_p.V490M|RIPK4_ENST00000332512.3_Missense_Mutation_p.V553M			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	553						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						AGGATGCGCACGATATTCTCC	0.662000													25	45					0	0	1	0	0
ADRBK2	157	broad.mit.edu	37	22	26057597	26057597	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr22:26057597C>T	ENST00000324198.6	+	4	511	c.319C>T	c.(319-321)Caa>Taa	p.Q107*		NM_005160.3	NP_005151.2	P35626	ARBK2_HUMAN	adrenergic, beta, receptor kinase 2		N-terminal.|RGS.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|skin(3)|stomach(2)	32					Adenosine triphosphate(DB00171)	CAGAAGTCGACAAATTTATGA	0.343000													18	43					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133541329	133541329	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr2:133541329G>A	ENST00000409261.1	-	14	3428	c.3055C>T	c.(3055-3057)Cga>Tga	p.R1019*	NCKAP5_ENST00000317721.6_Nonsense_Mutation_p.R1019*|NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1019							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						GCAGGGCATCGGGTTTGAATG	0.567000													19	36					0	0	1	0	0
SLC28A3	64078	broad.mit.edu	37	9	86903095	86903095	+	Splice_Site	SNP	T	T	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr9:86903095T>A	ENST00000376238.4	-	12	1199		c.e12-2		SLC28A3_ENST00000537648.1_Splice_Site|RP11-380F14.2_ENST00000419815.1_RNA	NM_001199633.1|NM_022127.2	NP_001186562.1|NP_071410.1	Q9HAS3	S28A3_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 3						nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			endometrium(2)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						GGATGGAACCTGCAATTTCAG	0.468000													65	112					0	0	1	0	0
MUC21	394263	broad.mit.edu	37	6	30954953	30954953	+	Missense_Mutation	SNP	A	A	G			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr6:30954953A>G	ENST00000376296.3	+	2	1242	c.1001A>G	c.(1000-1002)gAg>gGg	p.E334G	MUC21_ENST00000486149.2_5'UTR	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	334	28 X 15 AA approximate tandem repeats.|Ser-rich.					integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						ACCAACTCTGAGTCCAGCACG	0.622000													5	455					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025366	207025366	+	Silent	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr2:207025366G>A	ENST00000392222.2	+	2	510	c.135G>A	c.(133-135)ccG>ccA	p.P45P	EEF1B2_ENST00000236957.5_Silent_p.P45P|EEF1B2_ENST00000392221.1_Silent_p.P45P	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	45	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.P45P(5)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCAGCCCACCGCCTGCCGACT	0.448000													4	180					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101748113	101748113	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr9:101748113C>T	ENST00000375001.3	+	3	790	c.367C>T	c.(367-369)Cgg>Tgg	p.R123W		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	123	TSP N-terminal.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				CCTGGGCCTGCGGCTCTCAGG	0.632000													4	127					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14861995	14861995	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr3:14861995G>A	ENST00000285046.5	+	1	1527	c.1417G>A	c.(1417-1419)Gcg>Acg	p.A473T	FGD5_ENST00000543601.1_Missense_Mutation_p.A232T	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	473					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						CCTGGTTCCCGCGGACAGGAA	0.642000													33	67					0	0	1	0	0
GPR20	2843	broad.mit.edu	37	8	142367776	142367776	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr8:142367776C>T	ENST00000377741.3	-	2	338	c.248G>A	c.(247-249)cGg>cAg	p.R83Q		NM_005293.2	NP_005284.2	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	83						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(3)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	15	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			TGTCTTGGCCCGGGTGCGGCA	0.652000													20	71					0	0	1	0	0
RNF112	7732	broad.mit.edu	37	17	19318138	19318138	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr17:19318138G>A	ENST00000461366.1	+	10	1279	c.1064G>A	c.(1063-1065)cGt>cAt	p.R355H		NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	355							GTP binding|GTPase activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						AAGCGAGCCCGTTGCTGCCTC	0.617000													17	36					0	0	1	0	0
LOC100507053	100507053	broad.mit.edu	37	4	100082212	100082212	+	RNA	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr4:100082212G>A	ENST00000500358.2	+	0	3714				PCNAP1_ENST00000595299.1_RNA	NR_037884.1																						GTGTTACTGGGAAGAGAGAGT	0.408000													9	15					0	0	1	0	0
ALX4	60529	broad.mit.edu	37	11	44286677	44286677	+	Silent	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr11:44286677G>A	ENST00000329255.3	-	4	1066	c.963C>T	c.(961-963)tgC>tgT	p.C321C		NM_021926.3	NP_068745.2	Q9H161	ALX4_HUMAN	ALX homeobox 4	321					hair follicle development					central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	16						AGGGGACCACGCAGGCTGGCA	0.677000													21	40					0	0	1	0	0
MBNL3	55796	broad.mit.edu	37	X	131573638	131573638	+	Translation_Start_Site	SNP	A	A	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chrX:131573638A>T	ENST00000370857.3	-	1	67	c.2T>A	c.(1-3)aTg>aAg	p.M1K	MBNL3_ENST00000370839.3_Start_Codon_SNP_p.M1K|MBNL3_ENST00000370844.1_Intron|MBNL3_ENST00000370853.3_Start_Codon_SNP_p.M1K			Q9NUK0	MBNL3_HUMAN	muscleblind-like splicing regulator 3	1					mRNA processing|multicellular organismal development|regulation of RNA splicing|RNA splicing	Golgi apparatus|nucleus	nucleic acid binding|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|prostate(2)	16	Acute lymphoblastic leukemia(192;0.000127)					GACAGCCGTCATATTGAAAGC	0.378000													111	214					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60909090	60909090	+	Missense_Mutation	SNP	C	C	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr20:60909090C>A	ENST00000252999.3	-	23	2811	c.2745G>T	c.(2743-2745)agG>agT	p.R915S		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	915	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGCCACGATCCTGGGCTGGG	0.672000													12	26					0.00010058	0.00010058	1	1	0
GGNBP2	79893	broad.mit.edu	37	17	34941754	34941754	+	Missense_Mutation	SNP	A	A	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr17:34941754A>T	ENST00000304718.4	+	10	1556	c.1240A>T	c.(1240-1242)Agc>Tgc	p.S414C		NM_024835.3	NP_079111.1	Q9H3C7	GGNB2_HUMAN	gametogenetin binding protein 2	414					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)	38		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		AGAAAATAGCAGCTGCAAAGC	0.378000													55	111					0	0	1	0	0
RAPSN	5913	broad.mit.edu	37	11	47469404	47469404	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr11:47469404C>T	ENST00000298854.2	-	2	704	c.491G>A	c.(490-492)cGc>cAc	p.R164H	RAPSN_ENST00000524487.1_Missense_Mutation_p.R164H|RAPSN_ENST00000529341.1_Missense_Mutation_p.R164H|RAPSN_ENST00000352508.3_Missense_Mutation_p.R164H	NM_005055.4	NP_005046.2	Q13702	RAPSN_HUMAN	receptor-associated protein of the synapse	164			R -> C (in CMS-ACHRD; reduced coclustering with acetylcholine receptor).		synaptic transmission, cholinergic	cell junction|cytoskeleton|postsynaptic membrane	acetylcholine receptor binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(6)|ovary(2)	12						GCAGCACACGCGGCACTCGAG	0.632000													8	22					0	0	1	0	0
RLIM	51132	broad.mit.edu	37	X	73811938	73811938	+	Silent	SNP	G	G	C	rs61754468	by1000genomes	TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chrX:73811938G>C	ENST00000332687.6	-	4	1430	c.1212C>G	c.(1210-1212)acC>acG	p.T404T	RLIM_ENST00000349225.2_Silent_p.T404T	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	404					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding	p.T404T(6)		breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GCCTTAACATGGTCTGAATTG	0.413000													7	193					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1267410	1267410	+	Silent	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr11:1267410G>A	ENST00000447027.1	+	31	9367	c.9309G>A	c.(9307-9309)ccG>ccA	p.P3103P	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Silent_p.P3100P			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3100	17 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCTCCACTCCGGAGACCACCC	0.647000													54	134					0	0	1	0	0
QSOX2	169714	broad.mit.edu	37	9	139108552	139108552	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr9:139108552G>A	ENST00000358701.5	-	9	1140	c.1103C>T	c.(1102-1104)cCg>cTg	p.P368L		NM_181701.3	NP_859052.3	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2	368					cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity	p.P368L(1)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		CTTGACTGGCGGCCGTCCAGG	0.642000													29	78					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47846053	47846053	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr6:47846053C>T	ENST00000339488.4	-	3	2560	c.2527G>A	c.(2527-2529)Gtc>Atc	p.V843I		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	843						integral to membrane	hedgehog receptor activity										ACTGTGGTGACGTGATCCGGG	0.453000													68	183					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111427803	111427803	+	Missense_Mutation	SNP	A	A	G			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr4:111427803A>G	ENST00000265162.5	+	4	1271	c.929A>G	c.(928-930)tAt>tGt	p.Y310C		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	310					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CTTACAATTTATGTCCAGCCA	0.294000													34	57					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154157638	154157638	+	Missense_Mutation	SNP	C	C	T	rs142955808		TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chrX:154157638C>T	ENST00000360256.4	-	14	4627	c.4427G>A	c.(4426-4428)aGa>aAa	p.R1476K		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1476	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GCCAACCTCTCTTTGATCACC	0.438000													19	185					0	0	1	0	0
PCDHGC3	5098	broad.mit.edu	37	5	140857255	140857255	+	Silent	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr5:140857255C>T	ENST00000308177.3	+	1	1676	c.1572C>T	c.(1570-1572)ccC>ccT	p.P524P	PCDHGA11_ENST00000398587.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_002588.2|NM_032402.1	NP_002579.2|NP_115778.1														breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(2)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTTAGTGCCCCTAGACTATG	0.488000													38	91					0	0	1	0	0
OR8G1	26494	broad.mit.edu	37	11	124120628	124120628	+	RNA	SNP	T	T	G			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr11:124120628T>G	ENST00000341493.2	+	0	206				OR8G1_ENST00000534473.2_RNA	NM_001002905.1	NP_001002905.1	Q15617	OR8G1_HUMAN	olfactory receptor, family 8, subfamily G, member 1						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity						Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0569)|Lung(307;0.174)		CTGTCCTTCATTGACTTCTGC	0.493000													44	120					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25346809	25346809	+	RNA	SNP	G	G	C			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr15:25346809G>C	ENST00000546682.1	+	0	1475				SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA|SNORD116-27_ENST00000516087.1_RNA	NR_003361.1																						TGTGAGCTGAGGTCCAGCACA	0.418000													38	74					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45861583	45861583	+	Silent	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr21:45861583C>T	ENST00000397928.1	+	32	4840	c.4395C>T	c.(4393-4395)caC>caT	p.H1465H	TRPM2_ENST00000397932.2_Silent_p.H1515H|TRPM2_ENST00000300482.5_Silent_p.H1465H|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Silent_p.H1411H	NM_003307.3	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1465	Nudix hydrolase.					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						AGAACCTGCACGCCTGCGACT	0.662000													16	48					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107683420	107683420	+	Missense_Mutation	SNP	A	A	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chrX:107683420A>T	ENST00000328300.6	+	1	309	c.65A>T	c.(64-66)cAg>cTg	p.Q22L	COL4A5_ENST00000361603.2_Missense_Mutation_p.Q22L|COL4A5_ENST00000477429.1_3'UTR	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	22					axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						CTTTGGGGGCAGCCTGCAGAG	0.602000									Alport syndrome with Diffuse Leiomyomatosis				18	43					0	0	1	0	0
USP15	9958	broad.mit.edu	37	12	62778055	62778055	+	Missense_Mutation	SNP	G	G	C			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr12:62778055G>C	ENST00000280377.5	+	11	1503	c.1445G>C	c.(1444-1446)aGa>aCa	p.R482T	USP15_ENST00000353364.3_Missense_Mutation_p.R453T|USP15_ENST00000393654.3_Missense_Mutation_p.R457T	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	482					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		TACTTAGTTAGAATGGATCCA	0.313000													9	203					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179423251	179423251	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr2:179423251C>T	ENST00000589042.1	-	327	87159	c.86935G>A	c.(86935-86937)Gtt>Att	p.V28979I	TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V20106I|TTN_ENST00000342992.6_Missense_Mutation_p.V26411I|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V27338I|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V20039I|TTN_ENST00000460472.2_Missense_Mutation_p.V19914I|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	27338	Fibronectin type-III 111.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTGCTTCAACGACATAGTGT	0.428000													25	44					0	0	1	0	0
USP15	9958	broad.mit.edu	37	12	62777762	62777762	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr12:62777762G>A	ENST00000280377.5	+	10	1289	c.1231G>A	c.(1231-1233)Gat>Aat	p.D411N	USP15_ENST00000353364.3_Missense_Mutation_p.D382N|USP15_ENST00000393654.3_Missense_Mutation_p.D386N	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	411					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		AAAAGATGCAGATGGAAGGCC	0.333000													19	383					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154397004	154397004	+	Silent	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr5:154397004G>A	ENST00000435029.4	+	1	3745	c.3585G>A	c.(3583-3585)tcG>tcA	p.S1195S		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1195	Globular (By similarity).|Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TCCCAGAGTCGAAACATGGAG	0.507000													19	53					0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153599591	153599591	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chrX:153599591G>A	ENST00000422373.1	-	2	271	c.23C>T	c.(22-24)gCg>gTg	p.A8V	FLNA_ENST00000344736.4_Missense_Mutation_p.A8V|FLNA_ENST00000369850.3_Missense_Mutation_p.A8V|FLNA_ENST00000360319.4_Missense_Mutation_p.A8V	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	8	Actin-binding.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCTCTGGCCCGCCCGAGAGTG	0.721000													3	11					0	0	1	0	0
TMEM252	169693	broad.mit.edu	37	9	71155541	71155541	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr9:71155541G>A	ENST00000377311.3	-	1	242	c.190C>T	c.(190-192)Cgc>Tgc	p.R64C		NM_153237.1	NP_694969.1			transmembrane protein 252																		GTCACCTGGCGATAGTTGCTC	0.552000													16	38					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160042950	160042950	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr5:160042950G>A	ENST00000327245.5	-	17	3394	c.2548C>T	c.(2548-2550)Cgg>Tgg	p.R850W	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	850					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCCCATCTCCGGAAGTCCTCT	0.517000													33	66					0	0	1	0	0
KRT25	147183	broad.mit.edu	37	17	38906791	38906791	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr17:38906791G>A	ENST00000312150.4	-	6	1076	c.1016C>T	c.(1015-1017)gCg>gTg	p.A339V		NM_181534.3	NP_853512.1	Q7Z3Z0	K1C25_HUMAN	keratin 25	339	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity	p.A339V(1)		endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(4)	16		Breast(137;0.00526)				CTGGATCTGCGCCAGCTGCGC	0.562000													120	243					0	0	1	0	0
TMTC1	83857	broad.mit.edu	37	12	29904597	29904597	+	Splice_Site	SNP	A	A	C			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr12:29904597A>C	ENST00000256062.5	-	5	1088		c.e5+1		TMTC1_ENST00000551659.1_Splice_Site|TMTC1_ENST00000552618.1_Splice_Site|TMTC1_ENST00000539277.1_Splice_Site|TMTC1_ENST00000381224.2_Splice_Site	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1							integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					ccagcccagtacctcatcatg	0.567000													26	68					0	0	1	0	0
HECTD2	143279	broad.mit.edu	37	10	93185044	93185044	+	Missense_Mutation	SNP	G	G	C			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr10:93185044G>C	ENST00000446394.1	+	2	245	c.145G>C	c.(145-147)Gac>Cac	p.D49H	HECTD2_ENST00000371681.4_Missense_Mutation_p.D49H|HECTD2_ENST00000298068.5_Missense_Mutation_p.D49H	NM_001284274.1	NP_001271203.1	Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	49					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						TCAGGGTTTGGACAGAGGAGC	0.348000													38	32					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55221822	55221822	+	Missense_Mutation	SNP	C	C	T	rs149840192		TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr7:55221822C>T	ENST00000275493.2	+	7	1043	c.866C>T	c.(865-867)gCc>gTc	p.A289V	EGFR_ENST00000342916.3_Missense_Mutation_p.A289V|EGFR_ENST00000344576.2_Missense_Mutation_p.A289V|EGFR_ENST00000442591.1_Missense_Mutation_p.A289V|EGFR_ENST00000420316.2_Missense_Mutation_p.A289V|EGFR_ENST00000454757.2_Missense_Mutation_p.A236V|EGFR_ENST00000455089.1_Missense_Mutation_p.A244V	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	289					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.A289D(3)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			701	96					0	0	1	0	0
SYTL1	84958	broad.mit.edu	37	1	27675627	27675627	+	Silent	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr1:27675627G>A	ENST00000543823.1	+	5	978	c.516G>A	c.(514-516)gcG>gcA	p.A172A	SYTL1_ENST00000490170.1_3'UTR|SYTL1_ENST00000318074.5_Silent_p.A160A			Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	172					exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			NS(1)|large_intestine(4)|lung(5)|ovary(1)|urinary_tract(1)	12		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CTGAGGAGGCGTCCCAGGCCC	0.612000													36	75					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179650418	179650418	+	Missense_Mutation	SNP	G	G	A	rs149155733		TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr2:179650418G>A	ENST00000589042.1	-	15	2646	c.2422C>T	c.(2422-2424)Cgc>Tgc	p.R808C	TTN_ENST00000342175.6_Missense_Mutation_p.R762C|TTN_ENST00000342992.6_Missense_Mutation_p.R808C|TTN_ENST00000591111.1_Missense_Mutation_p.R808C|TTN_ENST00000359218.5_Missense_Mutation_p.R762C|TTN_ENST00000460472.2_Missense_Mutation_p.R762C|TTN_ENST00000360870.5_Missense_Mutation_p.R808C	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	808							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGCGGGGGCGTTTATCCACA	0.398000													50	117					0	0	1	0	0
WDHD1	11169	broad.mit.edu	37	14	55429521	55429521	+	Missense_Mutation	SNP	A	A	G			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr14:55429521A>G	ENST00000360586.3	-	20	2647	c.2582T>C	c.(2581-2583)gTt>gCt	p.V861A	WDHD1_ENST00000420358.2_Missense_Mutation_p.V738A|WDHD1_ENST00000359167.4_Missense_Mutation_p.V379A|WDHD1_ENST00000421192.1_Missense_Mutation_p.V738A	NM_007086.3	NP_009017.1	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	861						cytoplasm|nucleoplasm	DNA binding			breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(2)	42						ATCTTCTTCAACTTGATTTCT	0.368000													111	258					0	0	1	0	0
HSD17B11	51170	broad.mit.edu	37	4	88312103	88312103	+	Silent	SNP	C	C	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr4:88312103C>A	ENST00000358290.4	-	1	435	c.120G>T	c.(118-120)ctG>ctT	p.L40L	HSD17B11_ENST00000507286.1_Silent_p.L40L	NM_016245.3	NP_057329.2	Q8NBQ5	DHB11_HUMAN	hydroxysteroid (17-beta) dehydrogenase 11	40					androgen catabolic process|steroid biosynthetic process	cytoplasm|extracellular region	binding|estradiol 17-beta-dehydrogenase activity			cervix(1)|endometrium(4)|kidney(2)|lung(2)|ovary(2)	11		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000339)		CTCCTGTAATCAGCACGATTT	0.453000													54	116					6.4308e-24	6.49447e-24	1	1	0
OR14I1	401994	broad.mit.edu	37	1	248845349	248845349	+	Missense_Mutation	SNP	C	C	T	rs139712934		TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr1:248845349C>T	ENST00000342623.3	-	1	280	c.257G>A	c.(256-258)cGc>cAc	p.R86H		NM_001004734.1	NP_001004734.1	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I, member 1	86					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(4)|large_intestine(2)|lung(24)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	35						GGAGCTTCTGCGAGTCAGGGA	0.473000													20	37					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36301465	36301465	+	Silent	SNP	G	G	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr5:36301465G>T	ENST00000296604.3	-	1	539	c.54C>A	c.(52-54)acC>acA	p.T18T	RANBP3L_ENST00000502994.1_Silent_p.T18T|RANBP3L_ENST00000515759.1_Silent_p.T18T	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	18					intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			TCAGTTTACAGGTGTGCAAAC	0.527000													59	120					3.00467e-41	3.06476e-41	1	1	0
RPS3	6188	broad.mit.edu	37	11	75113439	75113439	+	Missense_Mutation	SNP	C	C	G			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr11:75113439C>G	ENST00000531188.1	+	4	361	c.299C>G	c.(298-300)gCc>gGc	p.A100G	RPS3_ENST00000527446.1_Missense_Mutation_p.A100G|RPS3_ENST00000526608.1_Missense_Mutation_p.A88G|RPS3_ENST00000278572.6_Missense_Mutation_p.A116G|RPS3_ENST00000529285.1_3'UTR|RPS3_ENST00000524851.1_Missense_Mutation_p.A100G|RPS3_ENST00000530164.1_Missense_Mutation_p.A100G|RPS3_ENST00000534440.1_Intron	NM_001005.4|NM_001260506.1|NM_001260507.1	NP_000996.2|NP_001247435.1|NP_001247436.1	P23396	RS3_HUMAN	ribosomal protein S3	100					activation of caspase activity|endocrine pancreas development|induction of apoptosis|negative regulation of DNA repair|negative regulation of NF-kappaB transcription factor activity|response to DNA damage stimulus|translational elongation|translational initiation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleus|ruffle membrane	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|iron-sulfur cluster binding|mRNA binding|NF-kappaB binding|protein kinase binding|structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	6						TGTGCCATTGCCCAGGCAGAG	0.458000													65	134					0	0	1	0	0
SEC16B	89866	broad.mit.edu	37	1	177930832	177930832	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr1:177930832C>T	ENST00000308284.6	-	6	769	c.680G>A	c.(679-681)cGt>cAt	p.R227H	RP4-798P15.3_ENST00000354921.3_RNA|SEC16B_ENST00000464631.2_Missense_Mutation_p.R227H	NM_033127.2	NP_149118.2	Q96JE7	SC16B_HUMAN	SEC16 homolog B (S. cerevisiae)	227					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane		p.R227H(1)		central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)|stomach(1)	35						ACCAGACTCACGCTGCTGGAG	0.512000													20	32					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105413442	105413442	+	Silent	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr14:105413442G>A	ENST00000333244.5	-	7	8465	c.8346C>T	c.(8344-8346)gaC>gaT	p.D2782D	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2782						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGCCTGGACGTCCACCTCCA	0.602000													158	338					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367197	234367197	+	Silent	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr1:234367197G>A	ENST00000366618.3	+	3	463	c.318G>A	c.(316-318)gcG>gcA	p.A106A	SLC35F3_ENST00000366617.3_Silent_p.A37A	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	37					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			CGGGCCCGGCGGAGGCCCAGG	0.736000													24	30					0	0	1	0	0
FAM220A	84792	broad.mit.edu	37	7	6370435	6370435	+	Silent	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr7:6370435C>T	ENST00000313324.4	-	2	818	c.351G>A	c.(349-351)gtG>gtA	p.V117V		NM_001037163.1	NP_001032240.1	Q7Z4H9	SIPAR_HUMAN	family with sequence similarity 220, member A	117						nucleus											CACTGCAGGACACCCGAGCAA	0.597000													27	96					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186280588	186280588	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr1:186280588G>A	ENST00000445192.2	+	10	3698	c.3653G>A	c.(3652-3654)cGt>cAt	p.R1218H	PRG4_ENST00000367483.4_Missense_Mutation_p.R1177H|PRG4_ENST00000367484.3_Missense_Mutation_p.R747H|PRG4_ENST00000367485.4_Missense_Mutation_p.R1125H|PRG4_ENST00000367486.3_Missense_Mutation_p.R1175H	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	1218	Hemopexin-like 2.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CAGTACTGGCGTTTTACCAAT	0.353000													69	171					0	0	1	0	0
STAG3L4	64940	broad.mit.edu	37	7	66785180	66785180	+	RNA	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr7:66785180G>A	ENST00000416602.2	+	0	810					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				AAACAATACAGCTATCCAAGG	0.368000													4	85					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108357142	108357142	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr10:108357142G>A	ENST00000263054.6	-	24	3239	c.3232C>T	c.(3232-3234)Cga>Tga	p.R1078*	SORCS1_ENST00000344440.6_Nonsense_Mutation_p.R1078*|SORCS1_ENST00000369698.1_Nonsense_Mutation_p.R613*	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	1078						integral to membrane	neuropeptide receptor activity|protein binding	p.R1078*(3)		breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ACAAGGACTCGGACTCCTGGC	0.507000													9	24					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43884232	43884232	+	Silent	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr12:43884232G>A	ENST00000389420.3	-	7	1082	c.1083C>T	c.(1081-1083)gaC>gaT	p.D361D	ADAMTS20_ENST00000553158.1_Silent_p.D361D	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	361	Peptidase M12B.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ATGAACAAATGTCTTCCCTTA	0.229000													5	16					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14513764	14513764	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr18:14513764C>T	ENST00000358970.5	-	10	1429	c.1430G>A	c.(1429-1431)cGg>cAg	p.R477Q		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	477								p.R477Q(12)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AAGTTGTTTCCGGGTATCATT	0.358000													5	169					0	0	1	0	0
DPY19L2P2	349152	broad.mit.edu	37	7	102883490	102883490	+	RNA	SNP	A	A	C			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr7:102883490A>C	ENST00000312132.4	-	0	2619																											CCAGTTCAGTACCACTGTAAA	0.303000													3	36					0	0	1	0	0
SLC6A16	28968	broad.mit.edu	37	19	49793874	49793874	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr19:49793874C>T	ENST00000454748.3	-	11	2130	c.1929G>A	c.(1927-1929)tgG>tgA	p.W643*	SLC6A16_ENST00000335875.4_Nonsense_Mutation_p.W643*			Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	643						integral to membrane|intracellular	neurotransmitter:sodium symporter activity			NS(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		TGCTTGAGTCCCAGGACATGT	0.522000													15	30					0	0	1	0	0
SLC7A5	8140	broad.mit.edu	37	16	87871512	87871512	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr16:87871512G>A	ENST00000261622.4	-	7	1144	c.1079C>T	c.(1078-1080)cCc>cTc	p.P360L	SLC7A5_ENST00000565644.1_Missense_Mutation_p.P94L	NM_003486.5	NP_003477.4	Q01650	LAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 5	360					blood coagulation|cell differentiation|cellular amino acid metabolic process|ion transport|leukocyte migration|nervous system development	apical plasma membrane|cytosol|integral to membrane	neutral amino acid transmembrane transporter activity|peptide antigen binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(80;0.049)		GAGGATGGAGGGCAGGTGGCC	0.647000													4	5					0	0	1	0	0
PLCXD3	345557	broad.mit.edu	37	5	41382519	41382519	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr5:41382519C>T	ENST00000377801.3	-	2	295	c.221G>A	c.(220-222)cGg>cAg	p.R74Q	PLCXD3_ENST00000328457.3_Missense_Mutation_p.R74Q			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	74	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						TAACCATTTCCGCATGAGCTT	0.468000													45	92					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166246283	166246283	+	Silent	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr2:166246283C>T	ENST00000357398.3	+	27	6257	c.5967C>T	c.(5965-5967)gaC>gaT	p.D1989D	SCN2A_ENST00000375427.2_Silent_p.D1989D|SCN2A_ENST00000283256.6_Silent_p.D1989D|SCN2A_ENST00000375437.2_Silent_p.D1989D			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1989					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TTGAAAAAGACAAATCAGAAA	0.373000													32	59					0	0	1	0	0
APOA4	337	broad.mit.edu	37	11	116691769	116691769	+	Silent	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr11:116691769G>A	ENST00000357780.3	-	3	1119	c.1005C>T	c.(1003-1005)gaC>gaT	p.D335D		NM_000482.3	NP_000473.2			apolipoprotein A-IV											cervix(1)|endometrium(2)|lung(10)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		GGCCTTCCACGTCCCCCGCAT	0.577000													54	91					0	0	1	0	0
KCNC2	3747	broad.mit.edu	37	12	75601452	75601452	+	Silent	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr12:75601452G>A	ENST00000549446.1	-	2	992	c.312C>T	c.(310-312)ttC>ttT	p.F104F	KCNC2_ENST00000540018.1_Silent_p.F104F|KCNC2_ENST00000341669.3_Silent_p.F104F|KCNC2_ENST00000393288.2_Silent_p.F104F|KCNC2_ENST00000550433.1_Silent_p.F104F|KCNC2_ENST00000548513.1_Silent_p.F104F|KCNC2_ENST00000298972.1_Silent_p.F104F|KCNC2_ENST00000350228.2_Silent_p.F104F	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	104					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						GGTGCCGGTCGAAGAAGAACT	0.716000													10	20					0	0	1	0	0
HORMAD1	84072	broad.mit.edu	37	1	150676784	150676784	+	Silent	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr1:150676784C>T	ENST00000368993.2	-	11	945	c.840G>A	c.(838-840)caG>caA	p.Q280Q	HORMAD1_ENST00000368995.4_Silent_p.Q200Q|HORMAD1_ENST00000361824.2_Silent_p.Q280Q|HORMAD1_ENST00000322343.7_Silent_p.Q273Q			Q86X24	HORM1_HUMAN	HORMA domain containing 1	280					blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(3)	16	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			GGTTTTTTTCCTGTTCTTCCA	0.308000													27	71					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55273104	55273104	+	Nonsense_Mutation	SNP	C	C	T	rs145189325		TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr7:55273104C>T	ENST00000275493.2	+	28	3604	c.3427C>T	c.(3427-3429)Cag>Tag	p.Q1143*	EGFR_ENST00000442591.1_Intron|EGFR_ENST00000454757.2_Nonsense_Mutation_p.Q1090*	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	1143					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAACACTGTCCAGCCCACCTG	0.592000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			741	119					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34029770	34029770	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr6:34029770G>A	ENST00000538487.2	-	4	1215	c.772C>T	c.(772-774)Cgg>Tgg	p.R258W	GRM4_ENST00000545715.1_5'UTR|GRM4_ENST00000374177.3_Missense_Mutation_p.R189W|GRM4_ENST00000455714.2_Missense_Mutation_p.R118W|GRM4_ENST00000609222.1_Missense_Mutation_p.R125W|GRM4_ENST00000535756.1_Missense_Mutation_p.R125W|GRM4_ENST00000544773.2_Missense_Mutation_p.R89W|GRM4_ENST00000374181.4_Missense_Mutation_p.R258W	NM_000841.2|NM_001256811.1	NP_000832.1|NP_001243740.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4						activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	TTGGGCTCCCGTGGTATCTTC	0.617000													43	84					0	0	1	0	0
MARS	4141	broad.mit.edu	37	12	57894183	57894183	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr12:57894183C>T	ENST00000262027.5	+	10	1305	c.1171C>T	c.(1171-1173)Cac>Tac	p.H391Y	MARS_ENST00000447721.2_3'UTR|MARS_ENST00000315473.5_Missense_Mutation_p.H157Y	NM_004990.3	NP_004981.2	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	391					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	33			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	GCGATGTGAGCACTGTGCTCG	0.567000													69	1005					0	0	1	0	0
TRGV3	6976	broad.mit.edu	37	7	38398650	38398650	+	RNA	SNP	A	A	C	rs76431362		TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr7:38398650A>C	ENST00000390346.2	-	0	113																											CTTAAAACTCAGGCCCCACTC	0.527000													5	44					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55902220	55902220	+	Silent	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr7:55902220C>T	ENST00000388975.3	-	6	734	c.618G>A	c.(616-618)acG>acA	p.T206T		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	206					cell cycle|cell division	septin complex	GTP binding|protein binding	p.T206T(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TATTCTTAAACGTCTGTAAAT	0.348000													19	68					0	0	1	0	0
ZNF41	7592	broad.mit.edu	37	X	47308233	47308233	+	Silent	SNP	G	G	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chrX:47308233G>T	ENST00000377065.4	-	5	1575	c.936C>A	c.(934-936)ccC>ccA	p.P312P	ZNF41_ENST00000397050.2_Silent_p.P322P|ZNF41_ENST00000313116.7_Silent_p.P312P	NM_153380.2	NP_700359.1	P51814	ZNF41_HUMAN	zinc finger protein 41	354						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|upper_aerodigestive_tract(2)	24		all_lung(315;0.000129)				CATCAACCTGGGGTTTCTGGG	0.423000													109	187					2.12943e-44	2.19396e-44	1	1	0
OR4F5	79501	broad.mit.edu	37	1	69557	69557	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr1:69557C>T	ENST00000335137.3	+	1	467	c.467C>T	c.(466-468)gCc>gTc	p.A156V		NM_001005484.1	NP_001005484.1	Q8NH21	OR4F5_HUMAN	olfactory receptor, family 4, subfamily F, member 5	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)|ovary(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;3.48e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.21e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TTGGCGTTTGCCGTGCACTTA	0.468000													7	602					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186114580	186114580	+	Missense_Mutation	SNP	G	G	A	rs141397809		TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr1:186114580G>A	ENST00000271588.4	+	92	14541	c.14312G>A	c.(14311-14313)cGg>cAg	p.R4771Q	HMCN1_ENST00000367492.2_Missense_Mutation_p.R4771Q	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4771	TSP type-1 5.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ACATGCAGCCGGACGTGTAAC	0.552000													42	56					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													3	38					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238053178	238053178	+	Missense_Mutation	SNP	A	A	G			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr1:238053178A>G	ENST00000366570.4	-	3	547	c.389T>C	c.(388-390)aTg>aCg	p.M130T	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	130					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TAGAAGATCCATAGGACACTT	0.552000													123	243					0	0	1	0	0
SLC2A1-AS1	440584	broad.mit.edu	37	1	43428494	43428496	+	RNA	DEL	GGT	GGT	-			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr1:43428494_43428496delGGT	ENST00000431759.1	+	0	529					NR_033967.1																						GTGGGGGAGGggtggtggtggtg	0.631													2	4	---	---	---	---					
MROH5	389690	broad.mit.edu	37	8	142447066	142447066	+	RNA	DEL	G	G	-			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr8:142447066delG	ENST00000606664.1	+	0	2422				MROH5_ENST00000430863.1_RNA																							TGCACTGGGTGGGGGGGTGGG	0.736													2	4	---	---	---	---					
PTGDR2	11251	broad.mit.edu	37	11	60620167	60620169	+	In_Frame_Del	DEL	GCG	GCG	-			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr11:60620167_60620169delGCG	ENST00000332539.4	-	2	1138_1140	c.1027_1029delCGC	c.(1027-1029)cgcdel	p.R343del		NM_004778.2	NP_004769.2	Q9Y5Y4	GPR44_HUMAN	prostaglandin D2 receptor 2	343					immune response	integral to plasma membrane	N-formyl peptide receptor activity										TGGAGGAGGTGCGGCGGCGGCGG	0.749													5	9	---	---	---	---					
RPS6KB2	6199	broad.mit.edu	37	11	67201678	67201678	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr11:67201678delT	ENST00000312629.5	+	12	1024	c.979delT	c.(979-981)tttfs	p.F328fs	AP003419.16_ENST00000535922.1_RNA	NM_003952.2	NP_003943.2	Q9UBS0	KS6B2_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide 2	328	Protein kinase.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of translational initiation|translation	nucleoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(3)|salivary_gland(1)|stomach(2)	25			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			GAGACATCCCTTTTTCCGGCA	0.632													8	789	---	---	---	---					
LOC100130950	100130950	broad.mit.edu	37	17	5096765	5096766	+	RNA	INS	-	-	A			TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr17:5096765_5096766insA	ENST00000571689.1	+	0	60				RP11-333E1.1_ENST00000575601.1_RNA	NR_034082.1																						ctcaaaaaaataaaaaaaaaaa	0.510													2	4	---	---	---	---					
TBC1D3P2	440452	broad.mit.edu	37	17	60347260	60347260	+	RNA	DEL	T	T	-	rs71816198		TCGA-FG-A70Z-01A-12D-A33T-08	TCGA-FG-A70Z-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	035c8e60-9e26-4ec3-a634-7ec95258faf5	67a7635e-6337-4ac9-967a-5b08e4d76db1	g.chr17:60347260delT	ENST00000581291.1	-	0	581																				breast(2)|kidney(1)|lung(2)	5						CTCTGAATGATTTTTTTTTTT	0.448													5	3	---	---	---	---					
