Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CEP192	55125	broad.mit.edu	37	18	13100327	13100327	+	Silent	SNP	A	A	G			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr18:13100327A>G	ENST00000506447.1	+	38	6767	c.6687A>G	c.(6685-6687)cgA>cgG	p.R2229R	CEP192_ENST00000540847.2_3'UTR|CEP192_ENST00000430049.2_Silent_p.R1754R|CEP192_ENST00000325971.8_Silent_p.R1633R	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1824										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TTCAAATTCGAGAAGATTTAA	0.343000													6	38					0	0	1	0	0
TNFRSF9	3604	broad.mit.edu	37	1	7998781	7998781	+	Splice_Site	SNP	C	C	A			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr1:7998781C>A	ENST00000377507.3	-	3	374	c.208G>T	c.(208-210)Ggt>Tgt	p.G70C		NM_001561.5	NP_001552.2	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily, member 9	70					induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity	p.G70C(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		GAACTCATACCTTTACACTGC	0.398000													11	93					2.27111e-07	2.48238e-07	1	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85459188	85459188	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr12:85459188C>T	ENST00000393217.2	+	9	2601	c.2540C>T	c.(2539-2541)gCa>gTa	p.A847V		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	847										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		TACATTGATGCACAGGTATGC	0.333000													7	53					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10128939	10128939	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr3:10128939G>A	ENST00000287647.3	+	34	3550	c.3457G>A	c.(3457-3459)Gaa>Aaa	p.E1153K	FANCD2_ENST00000383806.1_Missense_Mutation_p.E1153K|FANCD2_ENST00000419585.1_Missense_Mutation_p.E1153K|FANCD2OS_ENST00000524279.1_Intron|FANCD2OS_ENST00000436517.1_Intron|FANCD2_ENST00000383807.1_Missense_Mutation_p.E1153K	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	1153					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TCAGAACAAAGAAAAAATTGG	0.348000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				6	62					0	0	1	0	0
PCDH7	5099	broad.mit.edu	37	4	30724278	30724278	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr4:30724278G>A	ENST00000361762.2	+	1	2242	c.1234G>A	c.(1234-1236)Gtg>Atg	p.V412M	PCDH7_ENST00000543491.1_Missense_Mutation_p.V412M	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	412	Cadherin 3.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						GAACGACAACGTGCCGTCCAT	0.632000													4	37					0	0	1	0	0
GREM1	26585	broad.mit.edu	37	15	33023158	33023158	+	Silent	SNP	G	G	A			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr15:33023158G>A	ENST00000300177.4	+	2	456	c.267G>A	c.(265-267)ctG>ctA	p.L89L	GREM1_ENST00000560830.1_Silent_p.L48L|GREM1_ENST00000322805.4_Silent_p.L48L|GREM1_ENST00000560677.1_3'UTR	NM_001191322.1|NM_001191323.1|NM_013372.6	NP_001178251.1|NP_001178252.1|NP_037504.1	O60565	GREM1_HUMAN	gremlin 1, DAN family BMP antagonist	89					negative regulation of BMP signaling pathway|nervous system development|regulation of epithelial to mesenchymal transition	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(1)|lung(6)|prostate(1)	10		all_lung(180;1.49e-09)		all cancers(64;2.97e-18)|Epithelial(43;3.15e-12)|GBM - Glioblastoma multiforme(186;2.32e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0107)		GCAAATACCTGAAGCGAGACT	0.632000													7	31					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79207664	79207664	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr4:79207664G>A	ENST00000264895.6	+	14	1945	c.1505G>A	c.(1504-1506)gGc>gAc	p.G502D	FRAS1_ENST00000325942.6_Missense_Mutation_p.G502D|FRAS1_ENST00000264899.6_Missense_Mutation_p.G502D	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	502					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TGTGGGGACGGCTTCTACCAA	0.622000													3	50					0	0	1	0	0
NMS	129521	broad.mit.edu	37	2	101097609	101097609	+	Nonsense_Mutation	SNP	C	C	T	rs142655356		TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr2:101097609C>T	ENST00000376865.1	+	8	401	c.394C>T	c.(394-396)Cga>Tga	p.R132*		NM_001011717.1	NP_001011717.1	Q5H8A3	NMS_HUMAN	neuromedin S	132					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				breast(1)|large_intestine(4)|lung(7)|ovary(1)|stomach(1)	14						GACCTGGGGACGACCCTTTTT	0.423000													4	164					0	0	1	0	0
TAC3	6866	broad.mit.edu	37	12	57409569	57409569	+	Silent	SNP	G	G	A			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr12:57409569G>A	ENST00000458521.2	-	2	172	c.13C>T	c.(13-15)Ctg>Ttg	p.L5L	TAC3_ENST00000415231.1_Silent_p.L5L|TAC3_ENST00000441881.1_Silent_p.L5L	NM_013251.3	NP_037383.1	Q9UHF0	TKNK_HUMAN	tachykinin 3	5					female pregnancy|neuropeptide signaling pathway|tachykinin receptor signaling pathway	extracellular space|soluble fraction	receptor binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7						GTGAATAGCAGCATGATCCTC	0.547000													5	36					0	0	1	0	0
FEZ1	9638	broad.mit.edu	37	11	125359621	125359621	+	Missense_Mutation	SNP	G	G	C			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr11:125359621G>C	ENST00000278919.3	-	2	287	c.53C>G	c.(52-54)tCc>tGc	p.S18C	FEZ1_ENST00000524435.1_Missense_Mutation_p.S18C|FEZ1_ENST00000366139.3_Missense_Mutation_p.S18C	NM_005103.4	NP_005094.1	Q99689	FEZ1_HUMAN	fasciculation and elongation protein zeta 1 (zygin I)	18					axon guidance|cell adhesion|transport	microtubule|plasma membrane				breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	24	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0934)		CTCCGAGCAGGAGGGTCGAAG	0.537000													14	53					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129305068	129305068	+	Silent	SNP	C	C	G			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr3:129305068C>G	ENST00000393239.1	-	4	1846	c.1668G>C	c.(1666-1668)ggG>ggC	p.G556G	PLXND1_ENST00000324093.4_Silent_p.G556G			Q9Y4D7	PLXD1_HUMAN	plexin D1	556					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						CCACGCAGTCCCCACAGGTGG	0.692000													3	8					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791744	42791744	+	Missense_Mutation	SNP	C	C	A			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr19:42791744C>A	ENST00000572681.2	+	6	3425	c.3357C>A	c.(3355-3357)ttC>ttA	p.F1119L	CIC_ENST00000575354.2_Missense_Mutation_p.F210L|CIC_ENST00000160740.3_Missense_Mutation_p.F210L			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	210	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				TCATGATCTTCAGCAAGCGGC	0.622000			"""Mis, F, S"""		oligodendroglioma								9	34					2.17888e-05	2.32744e-05	1	1	0
ANK1	286	broad.mit.edu	37	8	41521247	41521247	+	Missense_Mutation	SNP	T	T	C			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr8:41521247T>C	ENST00000396942.1	-	40	5491	c.5408A>G	c.(5407-5409)cAg>cGg	p.Q1803R	ANK1_ENST00000265709.8_Missense_Mutation_p.Q1844R|ANK1_ENST00000522231.1_Missense_Mutation_p.Q78R|ANK1_ENST00000347528.4_Missense_Mutation_p.Q1803R|RP11-930P14.1_ENST00000522388.1_RNA|ANK1_ENST00000352337.4_Missense_Mutation_p.Q1803R|ANK1_ENST00000289734.7_Missense_Mutation_p.Q1803R|ANK1_ENST00000314214.8_Missense_Mutation_p.Q78R|RP11-930P14.1_ENST00000520418.1_RNA|ANK1_ENST00000379758.2_Missense_Mutation_p.Q1803R|ANK1_ENST00000522543.1_Missense_Mutation_p.Q78R|RP11-930P14.1_ENST00000585088.1_RNA|ANK1_ENST00000396945.1_Intron|ANK1_ENST00000457297.1_Missense_Mutation_p.Q78R			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1803	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TGGAATATTCTGAAACTCATT	0.512000													4	55					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73650092	73650092	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr2:73650092G>A	ENST00000264448.6	+	4	865	c.754G>A	c.(754-756)Gca>Aca	p.A252T	ALMS1_ENST00000377715.1_Missense_Mutation_p.A252T|ALMS1_ENST00000409009.1_Missense_Mutation_p.A210T	NM_015120.4	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	252					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						ACTAAGTTTTGCACCTCTGAG	0.378000													28	134					0	0	1	0	0
MED16	10025	broad.mit.edu	37	19	885978	885978	+	Missense_Mutation	SNP	C	C	G	rs137978287		TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr19:885978C>G	ENST00000312090.6	-	5	821	c.671G>C	c.(670-672)gGc>gCc	p.G224A	MED16_ENST00000606828.1_Intron|MED16_ENST00000589119.1_Missense_Mutation_p.G224A|MED16_ENST00000395808.3_Missense_Mutation_p.G224A|MED16_ENST00000269814.4_Missense_Mutation_p.G224A|MED16_ENST00000325464.1_Missense_Mutation_p.G224A			Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	224					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACGATGTTGCCGCCGCCGGT	0.701000													10	22					0	0	1	0	0
GALNT10	55568	broad.mit.edu	37	5	153755873	153755873	+	Missense_Mutation	SNP	T	T	C			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr5:153755873T>C	ENST00000297107.6	+	5	742	c.605T>C	c.(604-606)cTt>cCt	p.L202P	GALNT10_ENST00000377661.2_Intron|GALNT10_ENST00000425427.2_Missense_Mutation_p.L202P|SAP30L-AS1_ENST00000519727.1_RNA	NM_198321.3	NP_938080.1	Q86SR1	GLT10_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)	202	Catalytic subdomain A.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	32	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			TACATGGCCCTTTTCCCCAGT	0.502000													3	110					0	0	1	0	0
SEC14L5	9717	broad.mit.edu	37	16	5053535	5053535	+	Silent	SNP	C	C	T			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr16:5053535C>T	ENST00000251170.7	+	11	1443	c.1263C>T	c.(1261-1263)atC>atT	p.I421I		NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	421	CRAL-TRIO.					integral to membrane|intracellular	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						GGCTGCTCATCGTGCGAGCCC	0.657000													7	32					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								9	39					0	0	1	0	0
LTBP3	4054	broad.mit.edu	37	11	65320906	65320906	+	Silent	SNP	G	G	A			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr11:65320906G>A	ENST00000301873.5	-	4	1228	c.960C>T	c.(958-960)ccC>ccT	p.P320P	LTBP3_ENST00000322147.4_Silent_p.P320P|LTBP3_ENST00000536982.1_Intron	NM_001130144.2	NP_001123616.1	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding protein 3	320	TB 1.					extracellular region	calcium ion binding|growth factor binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(3)	23						ACTGCAGCTGGGGACACTTGT	0.667000													6	23					0	0	1	0	0
CNOT4	4850	broad.mit.edu	37	7	135078909	135078909	+	Missense_Mutation	SNP	T	T	C			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr7:135078909T>C	ENST00000428680.2	-	10	1658	c.1379A>G	c.(1378-1380)aAt>aGt	p.N460S	CNOT4_ENST00000423368.2_Missense_Mutation_p.N463S|CNOT4_ENST00000361528.4_Missense_Mutation_p.N460S|CNOT4_ENST00000356162.4_Intron|CNOT4_ENST00000541284.1_Missense_Mutation_p.N463S|CNOT4_ENST00000414802.1_Intron|CNOT4_ENST00000315544.5_Missense_Mutation_p.N463S|CNOT4_ENST00000451834.1_Missense_Mutation_p.N460S	NM_001008225.2	NP_001008226.1	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	463					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						ATTGAGAGAATTGGCATTTGT	0.502000													18	62					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4917591	4917591	+	Silent	SNP	C	C	T			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr7:4917591C>T	ENST00000399583.3	-	2	367	c.180G>A	c.(178-180)tcG>tcA	p.S60S	RADIL_ENST00000536091.1_Silent_p.S60S	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	60					cell adhesion|multicellular organismal development|signal transduction		protein binding	p.S60S(1)		NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CACCAGGGGCCGACAGCTGGG	0.657000													3	22					0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153583249	153583249	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chrX:153583249C>T	ENST00000422373.1	-	30	5385	c.5137G>A	c.(5137-5139)Gtc>Atc	p.V1713I	FLNA_ENST00000369856.3_5'UTR|FLNA_ENST00000360319.4_Missense_Mutation_p.V1713I|FLNA_ENST00000344736.4_Missense_Mutation_p.V1713I|FLNA_ENST00000369850.3_Missense_Mutation_p.V1721I	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	1721					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACACAGATGACGTATTTGCCC	0.622000													3	48					0	0	1	0	0
EIF2B1	1967	broad.mit.edu	37	12	124111476	124111476	+	Silent	SNP	T	T	C			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr12:124111476T>C	ENST00000537073.1	-	5	805	c.597A>G	c.(595-597)gcA>gcG	p.A199A	EIF2B1_ENST00000539951.1_Intron|EIF2B1_ENST00000424014.2_Intron			Q14232	EI2BA_HUMAN	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	0					cellular response to stimulus|oligodendrocyte development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex|membrane fraction|plasma membrane	protein binding|translation initiation factor activity			breast(1)|kidney(3)|large_intestine(2)|lung(3)|urinary_tract(1)	10	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.67e-05)|Epithelial(86;0.000353)|all cancers(50;0.00489)		TGAAAGGCAGTGCTGACTGCT	0.453000													3	2					0	0	1	0	0
TAS1R1	80835	broad.mit.edu	37	1	6639509	6639509	+	Silent	SNP	G	G	T			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr1:6639509G>T	ENST00000333172.6	+	6	2584	c.2391G>T	c.(2389-2391)ctG>ctT	p.L797L	TAS1R1_ENST00000328191.4_3'UTR|TAS1R1_ENST00000351136.3_Silent_p.L543L	NM_138697.3	NP_619642.2	Q7RTX1	TS1R1_HUMAN	taste receptor, type 1, member 1	797					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TGGCTGGGCTGAGCAGCCTGA	0.597000													7	29					0.00307968	0.00307968	1	1	0
ZNF37BP	100129482	broad.mit.edu	37	10	43016558	43016558	+	RNA	SNP	T	T	C			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr10:43016558T>C	ENST00000452075.3	-	0	1036					NR_026777.1																						GAATAGTTTCTACTGGTATTA	0.313000													27	60					0	0	1	0	0
CT47B1	643311	broad.mit.edu	37	X	120008870	120008870	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chrX:120008870C>T	ENST00000371311.3	-	1	909	c.655G>A	c.(655-657)Gcg>Acg	p.A219T		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	219										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						GCCTCCTCCGCGGGCTCCCTG	0.692000													7	145					0	0	1	0	0
CCNT1	904	broad.mit.edu	37	12	49087746	49087746	+	Silent	SNP	T	T	C			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr12:49087746T>C	ENST00000261900.3	-	9	1473	c.1251A>G	c.(1249-1251)caA>caG	p.Q417Q		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	417					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						CATATGCATATTGTGACTTCA	0.468000													39	121					0	0	1	0	0
SLC25A5	292	broad.mit.edu	37	X	118603879	118603879	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chrX:118603879G>A	ENST00000317881.8	+	2	483	c.367G>A	c.(367-369)Gca>Aca	p.A123T	SLC25A5_ENST00000460013.1_3'UTR	NM_001152.4	NP_001143.2	P05141	ADT2_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5	123					chromosome segregation|energy reserve metabolic process|interspecies interaction between organisms|regulation of insulin secretion|viral reproduction	integral to plasma membrane|mitochondrial inner membrane|mitochondrial nucleoid|MMXD complex	adenine transmembrane transporter activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|stomach(2)	12					Clodronate(DB00720)	GGGTGGTGCCGCAGGGGCCAC	0.527000													4	165					0	0	1	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12943140	12943140	+	Missense_Mutation	SNP	C	C	G			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr1:12943140C>G	ENST00000235349.5	-	2	146	c.76G>C	c.(76-78)Gcc>Ccc	p.A26P		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	26										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTGGACATGGCCAAAGCTTGG	0.577000													21	125					0	0	1	0	0
PRSS55	203074	broad.mit.edu	37	8	10387145	10387145	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr8:10387145G>A	ENST00000328655.3	+	2	323	c.283G>A	c.(283-285)Ggc>Agc	p.G95S	PRSS51_ENST00000523024.1_RNA|PRSS55_ENST00000522210.1_Missense_Mutation_p.G95S	NM_198464.3	NP_940866.2	Q6UWB4	PRS55_HUMAN	protease, serine, 55	95	Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)	31						TTTCTGTGGCGGCTCCATCCT	0.547000													30	268					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31618142	31618142	+	Missense_Mutation	SNP	T	T	C			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr14:31618142T>C	ENST00000399332.1	-	14	2868	c.2380A>G	c.(2380-2382)Aga>Gga	p.R794G	HECTD1_ENST00000553700.1_Missense_Mutation_p.R794G	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	794					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TTGGTTCCTCTATTAGATTCA	0.308000													8	54					0	0	1	0	0
SLC6A12	6539	broad.mit.edu	37	12	307979	307979	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr12:307979C>T	ENST00000428720.1	-	8	1573	c.830G>A	c.(829-831)cGc>cAc	p.R277H	SLC6A12_ENST00000536824.1_Missense_Mutation_p.R277H|SLC6A12_ENST00000359674.4_Missense_Mutation_p.R277H|SLC6A12_ENST00000424061.2_Missense_Mutation_p.R277H|SLC6A12_ENST00000397296.2_Missense_Mutation_p.R277H|SLC6A12_ENST00000538272.1_5'UTR	NM_001122848.2	NP_001116320.1	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 12	277					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			GTCCTTGAGGCGGAACAAATC	0.517000													14	72					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													4	130					0	0	1	0	0
CACTIN	58509	broad.mit.edu	37	19	3613264	3613264	+	Silent	SNP	G	G	A			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr19:3613264G>A	ENST00000429344.2	-	9	1630	c.1578C>T	c.(1576-1578)gaC>gaT	p.D526D	CACTIN_ENST00000248420.5_Silent_p.D526D|CACTIN-AS1_ENST00000592274.1_RNA|CACTIN_ENST00000221899.3_Silent_p.D458D	NM_001080543.1	NP_001074012.1			cactin, spliceosome C complex subunit																		CCCCGTCGCCGTCGCCCTCTG	0.761000													6	29					0	0	1	0	0
DAAM1	23002	broad.mit.edu	37	14	59797962	59797962	+	Silent	SNP	G	G	A			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr14:59797962G>A	ENST00000395125.1	+	13	1619	c.1596G>A	c.(1594-1596)tcG>tcA	p.S532S	DAAM1_ENST00000351081.1_Silent_p.S532S|DAAM1_ENST00000360909.3_Silent_p.S532S	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	532	FH1.|Pro-rich.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		GTGGACCCTCGCCTGGAGCAC	0.517000													14	81					0	0	1	0	0
GPR128	84873	broad.mit.edu	37	3	100378648	100378648	+	Missense_Mutation	SNP	C	C	G	rs144717099		TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr3:100378648C>G	ENST00000273352.3	+	14	2208	c.1940C>G	c.(1939-1941)tCg>tGg	p.S647W	GPR128_ENST00000475887.1_Missense_Mutation_p.S352W|GPR128_ENST00000481506.1_3'UTR	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	647					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						ATTACAATCTCGATCAAAGTG	0.438000													8	60					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76944310	76944310	+	Splice_Site	SNP	C	C	T			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chrX:76944310C>T	ENST00000373344.5	-	7	809		c.e7+1		ATRX_ENST00000395603.3_Splice_Site|ATRX_ENST00000480283.1_Splice_Site	NM_000489.3	NP_000480.3	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked						DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TCATTACATACCTTACAAATA	0.363000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						15	65					0	0	1	0	0
RBM7	10179	broad.mit.edu	37	11	114278301	114278301	+	Missense_Mutation	SNP	A	A	C			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr11:114278301A>C	ENST00000540163.1	+	5	1215	c.573A>C	c.(571-573)caA>caC	p.Q191H	RBM7_ENST00000544582.1_Intron|RP11-212D19.4_ENST00000544347.1_Intron|RBM7_ENST00000541475.1_3'UTR|RBM7_ENST00000375490.5_Missense_Mutation_p.Q192H|RBM7_ENST00000545678.1_Missense_Mutation_p.Q71H			Q9Y580	RBM7_HUMAN	RNA binding motif protein 7	191					meiosis		nucleotide binding|protein binding|RNA binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17		all_cancers(61;5.06e-12)|all_epithelial(67;5.3e-06)|all_hematologic(158;7.68e-05)|Acute lymphoblastic leukemia(157;0.000966)|Melanoma(852;0.00153)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.0818)|Prostate(24;0.104)		BRCA - Breast invasive adenocarcinoma(274;2.56e-06)|Epithelial(105;4.17e-05)|all cancers(92;0.000348)		AGTGGCGCCAAGGTACACCAT	0.438000													17	109					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113533219	113533219	+	Splice_Site	SNP	G	G	T			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr12:113533219G>T	ENST00000257600.3	+	8	2141	c.1638G>T	c.(1636-1638)aaG>aaT	p.K546N	DTX1_ENST00000547974.1_3'UTR	NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	546					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						AAGGCCGGAAGGTGGGTGCCC	0.632000													6	50					0.000157383	0.000164378	1	1	0
ACACB	32	broad.mit.edu	37	12	109703224	109703224	+	Missense_Mutation	SNP	G	G	T			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr12:109703224G>T	ENST00000338432.7	+	52	7263	c.7144G>T	c.(7144-7146)Gtg>Ttg	p.V2382L	ACACB_ENST00000377854.5_Missense_Mutation_p.V2312L|ACACB_ENST00000377848.3_Missense_Mutation_p.V2382L|ACACB_ENST00000543201.1_3'UTR			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	2382					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CCAGGTGGTTGTGCAGTGGCT	0.627000													6	28					0.000274275	0.000280238	1	1	0
LECT1	11061	broad.mit.edu	37	13	53298165	53298165	+	Silent	SNP	G	G	A			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr13:53298165G>A	ENST00000448904.2	-	4	545	c.435C>T	c.(433-435)ggC>ggT	p.G145G	LECT1_ENST00000377962.3_Silent_p.G145G	NM_001011705.1|NM_007015.2	NP_001011705.1|NP_008946.1	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1	145	BRICHOS.				cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	15		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		TGGTCACGGCGCCCACCTCAG	0.483000													10	13					0	0	1	0	0
EPC2	26122	broad.mit.edu	37	2	149447887	149447887	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr2:149447887delC	ENST00000258484.6	+	2	292	c.258delC	c.(256-258)tacfs	p.Y86fs	EPC2_ENST00000409654.1_Frame_Shift_Del_p.Y86fs	NM_015630.3	NP_056445.3	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2 (Drosophila)	86					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0516)		TCAACTATTACAATCGCTTGT	0.348													19	114	---	---	---	---					
NUTM2F	54754	broad.mit.edu	37	9	97080945	97080947	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr9:97080945_97080947delAGA	ENST00000253262.4	-	7	2091_2093	c.2071_2073delTCT	c.(2071-2073)tctdel	p.S691del	NUTM2F_ENST00000341207.4_In_Frame_Del_p.S676del|NUTM2F_ENST00000335456.7_Intron	NM_017561.1	NP_060031.1			NUT family member 2F									p.S557delS(1)									TGCTGGCAGGAGAAGGTGATGGG	0.611													6	4	---	---	---	---					
TUBA1A	7846	broad.mit.edu	37	12	49580473	49580476	+	Frame_Shift_Del	DEL	GAAG	GAAG	-			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr12:49580473_49580476delGAAG	ENST00000301071.7	-	2	488_491	c.144_147delCTTC	c.(142-147)tccttcfs	p.SF48fs	TUBA1A_ENST00000295766.5_Frame_Shift_Del_p.SF48fs|TUBA1A_ENST00000550767.1_Frame_Shift_Del_p.SF13fs|TUBA1A_ENST00000546918.1_Frame_Shift_Del_p.SF48fs	NM_001270400.1|NM_006009.3	NP_001257329.1|NP_006000.2	Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	48					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity			stomach(1)|upper_aerodigestive_tract(1)	2						AGAAGGTGTTGAAGGAATCATCTC	0.559													21	117	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													4	8	---	---	---	---					
SDK2	54549	broad.mit.edu	37	17	71382018	71382018	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FG-A713-01A-11D-A32B-08	TCGA-FG-A713-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed89386f-0b6c-4b6b-bbac-c869aa72a025	bc2fa6a0-87a9-4052-a9ee-9a1d54413f32	g.chr17:71382018delG	ENST00000392650.3	-	32	4537	c.4537delC	c.(4537-4539)cacfs	p.H1513fs	SDK2_ENST00000388726.3_Frame_Shift_Del_p.H1513fs	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1513	Fibronectin type-III 10.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GTGGTGGTGTGGGGCGTCACG	0.632													2	4	---	---	---	---					
