Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR4C15	81309	broad.mit.edu	37	11	55322062	55322062	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr11:55322062A>G	ENST00000314644.2	+	1	280	c.280A>G	c.(280-282)Aac>Gac	p.N94D		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						TGTTGGGGGCAACATGCTAAT	0.438000										HNSCC(20;0.049)			12	146					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123366171	123366171	+	Missense_Mutation	SNP	G	G	A	rs142010566	by1000genomes	TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr3:123366171G>A	ENST00000360772.3	-	28	4897	c.4519C>T	c.(4519-4521)Cgg>Tgg	p.R1507W	MYLK_ENST00000475616.1_Missense_Mutation_p.R1507W|MYLK_ENST00000359169.1_Missense_Mutation_p.R1507W|MYLK_ENST00000346322.5_Missense_Mutation_p.R1438W|MYLK_ENST00000354792.5_Missense_Mutation_p.R307W|MYLK_ENST00000360304.3_Missense_Mutation_p.R1507W			Q15746	MYLK_HUMAN	myosin light chain kinase	1507	Protein kinase.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ATCTCCTGCCGGATATTCTCT	0.458000													4	62					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1268645	1268645	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr5:1268645G>A	ENST00000310581.5	-	9	2629	c.2572C>T	c.(2572-2574)Cgg>Tgg	p.R858W	TERT_ENST00000296820.5_Missense_Mutation_p.S797L|TERT_ENST00000508104.2_Missense_Mutation_p.S797L|TERT_ENST00000334602.6_Missense_Mutation_p.R858W	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	858	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CCGTCCCGCCGAATCCCCGCA	0.602000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				15	27					0	0	1	0	0
SYNDIG1L	646658	broad.mit.edu	37	14	74876137	74876137	+	Missense_Mutation	SNP	T	T	A			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr14:74876137T>A	ENST00000331628.3	-	2	558	c.311A>T	c.(310-312)cAg>cTg	p.Q104L	SYNDIG1L_ENST00000554823.1_Missense_Mutation_p.Q104L	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	104					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						TCCTGTGGGCTGCTCTGGAGG	0.617000													33	56					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	C	T	rs28934576	by1000genomes	TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr17:7577120C>T	ENST00000420246.2	-	8	950	c.818G>A	c.(817-819)cGt>cAt	p.R273H	TP53_ENST00000445888.2_Missense_Mutation_p.R273H|TP53_ENST00000359597.4_Missense_Mutation_p.R273H|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.R273H|TP53_ENST00000269305.4_Missense_Mutation_p.R273H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	273	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation; abolishes sequence-specific DNA binding; dbSNP:rs28934576).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(521)|p.R273L(93)|p.R273P(32)|p.0?(8)|p.?(2)|p.R273fs*32(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273S(1)|p.E258fs*71(1)|p.R273fs*72(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.R273fs*33(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542000	R273H(EN_ENDOMETRIUM)|R273H(HEC59_ENDOMETRIUM)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(MDAMB468_BREAST)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(NCIH1155_LUNG)|R273H(NCIH1793_LUNG)|R273H(NCIH1975_LUNG)|R273H(NCIH2405_LUNG)|R273H(NCIH508_LARGE_INTESTINE)|R273H(OC314_OVARY)|R273H(PANC1_PANCREAS)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SKMEL30_SKIN)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SUIT2_PANCREAS)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(SW480_LARGE_INTESTINE)|R273H(SW620_LARGE_INTESTINE)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	11					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411235	126411235	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr4:126411235T>C	ENST00000394329.3	+	17	13271	c.13258T>C	c.(13258-13260)Tat>Cat	p.Y4420H	FAT4_ENST00000335110.5_Missense_Mutation_p.Y2661H	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4420					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TAATCAGTGGTATGCCTACAG	0.577000													50	99					0	0	1	0	0
EQTN	54586	broad.mit.edu	37	9	27284786	27284786	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr9:27284786T>C	ENST00000380032.3	-	8	903	c.820A>G	c.(820-822)Acg>Gcg	p.T274A	EQTN_ENST00000537675.1_Missense_Mutation_p.T245A	NM_020641.2	NP_065692.2			equatorin, sperm acrosome associated																		ATGATATCCGTCATTATCTTA	0.408000													42	58					0	0	1	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	30					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71347515	71347515	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr4:71347515G>T	ENST00000413702.1	+	4	1342	c.1054G>T	c.(1054-1056)Ggc>Tgc	p.G352C	MUC7_ENST00000304887.5_Missense_Mutation_p.G352C|MUC7_ENST00000456088.1_Missense_Mutation_p.G352C	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	352						extracellular region	protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			TTCAGCTCCTGGCCAAAATAA	0.373000													25	41					4.81078e-24	5.17616e-24	1	1	0
FLT3	2322	broad.mit.edu	37	13	28636085	28636085	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr13:28636085T>C	ENST00000380982.4	-	3	368	c.287A>G	c.(286-288)gAc>gGc	p.D96G	FLT3_ENST00000537084.1_Missense_Mutation_p.D96G|FLT3_ENST00000241453.7_Missense_Mutation_p.D96G			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	96					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CCCTGGGGCGTCGACCAGCAC	0.522000			"""Mis, O"""		"""AML, ALL"""								4	21					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247752350	247752350	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr1:247752350G>T	ENST00000320065.1	+	1	689	c.689G>T	c.(688-690)aGg>aTg	p.R230M	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GCAGTGTTGAGGATTAAGTCA	0.473000													65	44					4.83814e-26	5.27233e-26	1	1	0
HOOK1	51361	broad.mit.edu	37	1	60314160	60314160	+	Missense_Mutation	SNP	G	G	A	rs143143349		TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr1:60314160G>A	ENST00000371208.3	+	11	1360	c.1103G>A	c.(1102-1104)cGt>cAt	p.R368H	HOOK1_ENST00000395561.2_Missense_Mutation_p.R326H|HOOK1_ENST00000465876.1_3'UTR	NM_015888.4	NP_056972.1	Q9UJC3	HOOK1_HUMAN	hook microtubule-tethering protein 1	368	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			biliary_tract(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|urinary_tract(1)	29	all_cancers(7;0.000129)					AATGCAGCACGTACACAATTA	0.308000													5	62					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61622338	61622338	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr2:61622338C>T	ENST00000398571.2	-	4	659	c.583G>A	c.(583-585)Ggg>Agg	p.G195R		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	195					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			CAGAATGCCCCTAATATGTTA	0.224000													8	30					0	0	1	0	0
CCDC174	51244	broad.mit.edu	37	3	14709604	14709604	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr3:14709604G>T	ENST00000383794.3	+	9	941	c.868G>T	c.(868-870)Gct>Tct	p.A290S	CCDC174_ENST00000303688.7_Intron|CCDC174_ENST00000476763.1_3'UTR	NM_016474.4	NP_057558.3			coiled-coil domain containing 174																		AAAGCGAAAGGCTATCTTAGA	0.343000													27	49					1.42536e-11	1.4775e-11	1	1	0
DCUN1D3	123879	broad.mit.edu	37	16	20871683	20871683	+	Missense_Mutation	SNP	A	A	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr16:20871683A>C	ENST00000324344.4	-	3	725	c.440T>G	c.(439-441)tTt>tGt	p.F147C	DCUN1D3_ENST00000563934.1_Missense_Mutation_p.F147C|ERI2_ENST00000564349.1_Intron	NM_173475.2	NP_775746.1	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 3		DCUN1.				negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				NS(2)|breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)	14				GBM - Glioblastoma multiforme(48;0.249)		GCCATCAAAAAACTCCTTCCT	0.393000													17	27					0	0	1	0	0
NCAPG2	54892	broad.mit.edu	37	7	158443658	158443658	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr7:158443658A>G	ENST00000409339.3	-	24	3054	c.2941T>C	c.(2941-2943)Tat>Cat	p.Y981H	NCAPG2_ENST00000449727.2_Missense_Mutation_p.Y981H|NCAPG2_ENST00000541468.1_Intron|NCAPG2_ENST00000275830.10_Intron|NCAPG2_ENST00000356309.3_Missense_Mutation_p.Y981H|NCAPG2_ENST00000409423.1_Missense_Mutation_p.Y981H	NM_001281933.1	NP_001268862.1	Q86XI2	CNDG2_HUMAN	non-SMC condensin II complex, subunit G2	981					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	39	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		TGAACAGAATAAAGCAGCTAC	0.393000													4	69					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20570701	20570701	+	Missense_Mutation	SNP	A	A	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr16:20570701A>C	ENST00000329697.6	-	3	414	c.246T>G	c.(244-246)aaT>aaG	p.N82K	ACSM2B_ENST00000565322.1_Missense_Mutation_p.N3K|ACSM2B_ENST00000414188.2_Missense_Mutation_p.N82K|ACSM2B_ENST00000565232.1_Missense_Mutation_p.N82K|ACSM2B_ENST00000567001.1_Missense_Mutation_p.N82K	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	82					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						GTTCTCTGAAATTCCACATTA	0.577000													9	10					0	0	1	0	0
PRRX2	51450	broad.mit.edu	37	9	132482974	132482974	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr9:132482974G>A	ENST00000372469.4	+	3	774	c.547G>A	c.(547-549)Gcc>Acc	p.A183T		NM_016307.3	NP_057391.1	Q99811	PRRX2_HUMAN	paired related homeobox 2	183						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(2)|pancreas(1)	3		Ovarian(14;0.00556)				CCAGGAGGCCGCCATCGAGCA	0.647000													28	60					0	0	1	0	0
GPR111	222611	broad.mit.edu	37	6	47647822	47647822	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr6:47647822G>T	ENST00000398742.2	+	4	332	c.283G>T	c.(283-285)Gtt>Ttt	p.V95F	GPR111_ENST00000507065.1_Missense_Mutation_p.V95F|GPR111_ENST00000296862.1_Missense_Mutation_p.V163F			Q8IZF7	GP111_HUMAN	G protein-coupled receptor 111	163					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(15)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						TTCACGTTTGGTTCAGCCATT	0.308000													11	23					1.58986e-06	1.62817e-06	1	1	0
DHRS7C	201140	broad.mit.edu	37	17	9683322	9683322	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr17:9683322G>C	ENST00000330255.5	-	3	313	c.301C>G	c.(301-303)Ctc>Gtc	p.L101V	DHRS7C_ENST00000571134.1_Missense_Mutation_p.L100V	NM_001105571.2|NM_001220493.1	NP_001099041.1|NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C							extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						ATGTCTGAGAGGTCCAACAGG	0.527000													7	20					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186014861	186014861	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr1:186014861C>T	ENST00000271588.4	+	41	6575	c.6346C>T	c.(6346-6348)Ctc>Ttc	p.L2116F	HMCN1_ENST00000367492.2_Missense_Mutation_p.L2116F	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2116	Ig-like C2-type 19.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TGTCTCTGTCCTCATTAGCCA	0.433000													21	53					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76497400	76497400	+	Nonsense_Mutation	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr17:76497400C>T	ENST00000389840.5	-	35	5431	c.5307G>A	c.(5305-5307)tgG>tgA	p.W1769*	DNAH17-AS1_ENST00000598378.1_3'UTR|DNAH17_ENST00000585328.1_Nonsense_Mutation_p.W1778*					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GCTGGGCCTGCCAGGTGAAGG	0.567000													15	24					0	0	1	0	0
IL5	3567	broad.mit.edu	37	5	131879049	131879049	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr5:131879049C>T	ENST00000231454.1	-	1	165	c.122G>A	c.(121-123)cGa>cAa	p.R41Q		NM_000879.2	NP_000870.1	P05113	IL5_HUMAN	interleukin 5 (colony-stimulating factor, eosinophil)	41					immune response|inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of podosome assembly	extracellular space	cytokine activity|growth factor activity|interleukin-5 receptor binding			endometrium(1)|large_intestine(1)|stomach(1)|upper_aerodigestive_tract(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Pranlukast(DB01411)	CAGCAGAGTTCGATGAGTAGA	0.418000													15	30					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37431045	37431045	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr10:37431045C>T	ENST00000374660.1	+	7	1151	c.1052C>T	c.(1051-1053)aCg>aTg	p.T351M	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.T351M|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.T351M			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	407						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						GAGAAATTTACGTGGGCAGCA	0.423000													43	51					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103335639	103335639	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr8:103335639T>C	ENST00000520539.1	-	14	2290	c.1684A>G	c.(1684-1686)Atg>Gtg	p.M562V	UBR5_ENST00000220959.4_Missense_Mutation_p.M562V|UBR5_ENST00000521922.1_Missense_Mutation_p.M556V	NM_001282873.1|NM_015902.5	NP_001269802.1|NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	562					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			ACTGACTCCATTAAGACACCA	0.363000													16	29					0	0	1	0	0
OPN4	94233	broad.mit.edu	37	10	88418319	88418319	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr10:88418319G>A	ENST00000372071.2	+	5	763	c.536G>A	c.(535-537)cGc>cAc	p.R179H	OPN4_ENST00000241891.5_Missense_Mutation_p.R168H	NM_001030015.2	NP_001025186.1	Q9UHM6	OPN4_HUMAN	opsin 4	168					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(5)|ovary(3)	18						GCCCTGGACCGCTACCTGGTA	0.617000													15	26					0	0	1	0	0
OR12D2	26529	broad.mit.edu	37	6	29364624	29364624	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr6:29364624G>T	ENST00000383555.2	+	1	209	c.148G>T	c.(148-150)Gat>Tat	p.D50Y	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						TGTCATCTCCGATCCTAGACT	0.453000													36	64					6.97489e-18	7.31933e-18	1	1	0
POLB	5423	broad.mit.edu	37	8	42229122	42229122	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr8:42229122A>G	ENST00000265421.4	+	14	1125	c.955A>G	c.(955-957)Atc>Gtc	p.I319V	POLB_ENST00000521492.1_Missense_Mutation_p.I38V|POLB_ENST00000538005.1_Missense_Mutation_p.I165V	NM_002690.2	NP_002681.1	P06746	DPOLB_HUMAN	polymerase (DNA directed), beta	319					DNA-dependent DNA replication	cytoplasm|nucleoplasm|spindle microtubule	DNA-(apurinic or apyrimidinic site) lyase activity|DNA-directed DNA polymerase activity|enzyme binding|metal ion binding|microtubule binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(5)|ovary(1)	16	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.18e-11)|Lung(22;0.00467)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|LUSC - Lung squamous cell carcinoma(45;0.024)		Cytarabine(DB00987)	TGAAAAAGACATCTTTGATTA	0.438000								DNA polymerases (catalytic subunits)					12	41					0	0	1	0	0
CPA4	51200	broad.mit.edu	37	7	129962408	129962408	+	Silent	SNP	C	C	T	rs143728099	byFrequency	TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr7:129962408C>T	ENST00000222482.4	+	11	1186	c.1158C>T	c.(1156-1158)acC>acT	p.T386T	CPA4_ENST00000493259.1_Silent_p.T282T|CPA4_ENST00000445470.2_Silent_p.T353T	NM_016352.3	NP_057436.2	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4	386					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Melanoma(18;0.0435)					TGAGAGATACCGGGACCTATG	0.537000													45	62					0	0	1	0	0
UGT2A1	10941	broad.mit.edu	37	4	70455139	70455139	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr4:70455139A>T	ENST00000503640.1	-	6	1590	c.1535T>A	c.(1534-1536)tTt>tAt	p.F512Y	UGT2A2_ENST00000457664.2_Missense_Mutation_p.F521Y|UGT2A1_ENST00000512704.1_Missense_Mutation_p.F468Y|UGT2A1_ENST00000514019.1_Missense_Mutation_p.F678Y|UGT2A1_ENST00000286604.4_Missense_Mutation_p.F512Y	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	512					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						TTGACAGGAAAACAAACAACA	0.353000													27	55					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50611777	50611777	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr7:50611777C>T	ENST00000444124.2	-	2	207	c.7G>A	c.(7-9)Gca>Aca	p.A3T	DDC_ENST00000426377.1_Missense_Mutation_p.A3T|DDC_ENST00000380984.4_Missense_Mutation_p.A3T|DDC_ENST00000357936.5_Missense_Mutation_p.A3T|DDC_ENST00000431062.1_Missense_Mutation_p.A3T	NM_001082971.1	NP_001076440	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	3					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	AATTCACTTGCGTTCATGGTG	0.512000													4	106					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247752061	247752061	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr1:247752061C>A	ENST00000320065.1	+	1	400	c.400C>A	c.(400-402)Cat>Aat	p.H134N	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CCGTCCTCTCCATTACACTGT	0.547000													46	185					8.48111e-28	9.36226e-28	1	1	0
TRIM56	81844	broad.mit.edu	37	7	100730605	100730605	+	Silent	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr7:100730605C>T	ENST00000306085.6	+	3	309	c.12C>T	c.(10-12)caC>caT	p.H4H		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	4					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					TGGTTTCCCACGGGTCCTCGC	0.637000													8	130					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28986302	28986302	+	Silent	SNP	T	T	A			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr18:28986302T>A	ENST00000359747.4	+	12	1928	c.1899T>A	c.(1897-1899)atT>atA	p.I633I	DSG4_ENST00000308128.4_Silent_p.I633I|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	633					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CAGCAGGGATTGGCATGATGG	0.473000													42	113					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088171	9088171	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr19:9088171C>A	ENST00000397910.4	-	1	3847	c.3644G>T	c.(3643-3645)aGc>aTc	p.S1215I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1215	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AACCAGGGTGCTTTTTCCTAT	0.493000													77	133					8.07507e-42	9.03133e-42	1	1	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								17	44					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70990039	70990039	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr14:70990039T>C	ENST00000256389.3	-	2	1830	c.1586A>G	c.(1585-1587)aAt>aGt	p.N529S	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	479	Cys-rich.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		GGATGTCCCATTGCACCACTC	0.433000													53	69					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161578	90161578	+	RNA	SNP	G	G	A	rs13337896	by1000genomes	TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr16:90161578G>A	ENST00000564451.1	+	0	931				TUBB8P7_ENST00000567960.1_RNA														p.R105H(3)									GCCAAGGGACGCTACACCGAA	0.587000													3	24					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92714787	92714787	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr11:92714787C>T	ENST00000257068.2	+	2	404	c.398C>T	c.(397-399)gCc>gTc	p.A133V		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	133					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	AATATCACTGCCATCGCCATT	0.597000													20	44					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102431051	102431051	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr14:102431051G>C	ENST00000360184.4	+	1	187	c.23G>C	c.(22-24)gGc>gCc	p.G8A		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	8					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						GGGGGCGGCGGCGGCGAGGAC	0.682000													4	16					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25490697	25490697	+	RNA	SNP	G	G	A			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr15:25490697G>A	ENST00000453082.2	+	0	2719				SNORD115-41_ENST00000363608.1_RNA	NR_003343.1																						ATAGGATTACGCTGAGGCCCA	0.498000													6	385					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597832.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													4	13					2.56e-06	2.59048e-06	1	1	0
SHKBP1	92799	broad.mit.edu	37	19	41096689	41096689	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr19:41096689G>A	ENST00000291842.5	+	17	1871	c.1822G>A	c.(1822-1824)Gcc>Acc	p.A608T	SHKBP1_ENST00000600733.1_Missense_Mutation_p.A583T	NM_138392.3	NP_612401.2	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	608						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(3)|urinary_tract(1)	29			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTGTGAGCTGGCCCCGCCGGC	0.657000													34	38					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155505789	155505789	+	Silent	SNP	G	G	A			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr4:155505789G>A	ENST00000302053.3	-	6	2166	c.2088C>T	c.(2086-2088)ttC>ttT	p.F696F		NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	696	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TCAGGCTGCCGAAACCTCTCT	0.488000													22	53					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13758953	13758953	+	Splice_Site	SNP	A	A	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr5:13758953A>T	ENST00000265104.4	-	61	10524		c.e61+1			NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AAGGGCAGTTACCTGCTTTTC	0.493000									Kartagener syndrome				42	56					0	0	1	0	0
EDA2R	60401	broad.mit.edu	37	X	65835830	65835830	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chrX:65835830T>C	ENST00000451436.2	-	2	98	c.17A>G	c.(16-18)aAt>aGt	p.N6S	EDA2R_ENST00000450752.1_Silent_p.Q11Q|EDA2R_ENST00000396050.1_Silent_p.Q11Q|EDA2R_ENST00000456230.2_Silent_p.Q11Q|EDA2R_ENST00000253392.5_Silent_p.Q11Q|EDA2R_ENST00000374719.3_Silent_p.Q11Q			Q9HAV5	TNR27_HUMAN	ectodysplasin A2 receptor	0					cell differentiation|embryo development|epidermis development|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	13						ACCGTCCCCATTGGTCCCAGT	0.483000													14	4					0	0	1	0	0
OR10H2	26538	broad.mit.edu	37	19	15839146	15839146	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr19:15839146C>T	ENST00000305899.3	+	1	313	c.293C>T	c.(292-294)gCc>gTc	p.A98V		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A98D(1)		breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					CTGGCCTGTGCCAGTCAGATG	0.632000													15	41					0	0	1	0	0
OPRM1	4988	broad.mit.edu	37	6	154412154	154412154	+	Nonsense_Mutation	SNP	T	T	A			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr6:154412154T>A	ENST00000414028.2	+	3	761	c.711T>A	c.(709-711)tgT>tgA	p.C237*	OPRM1_ENST00000518759.1_Nonsense_Mutation_p.C156*|OPRM1_ENST00000337049.4_Nonsense_Mutation_p.C237*|OPRM1_ENST00000520708.1_Nonsense_Mutation_p.C137*|OPRM1_ENST00000452687.2_Nonsense_Mutation_p.C237*|OPRM1_ENST00000434900.2_Nonsense_Mutation_p.C330*|OPRM1_ENST00000435918.2_Nonsense_Mutation_p.C237*|OPRM1_ENST00000524163.1_Nonsense_Mutation_p.C237*|OPRM1_ENST00000360422.4_Nonsense_Mutation_p.C237*|OPRM1_ENST00000522555.1_Nonsense_Mutation_p.C137*|OPRM1_ENST00000428397.2_Nonsense_Mutation_p.C237*|OPRM1_ENST00000522236.1_Nonsense_Mutation_p.C137*|OPRM1_ENST00000330432.7_Nonsense_Mutation_p.C237*|OPRM1_ENST00000229768.5_Nonsense_Mutation_p.C237*|OPRM1_ENST00000419506.2_Nonsense_Mutation_p.C237*	NM_001145284.2	NP_001138756.1	P35372	OPRM_HUMAN	opioid receptor, mu 1	237					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	TGAAGATCTGTGTTTTCATCT	0.438000													43	49					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66458525	66458525	+	Silent	SNP	A	A	G			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr5:66458525A>G	ENST00000404260.3	+	28	4193	c.3885A>G	c.(3883-3885)tcA>tcG	p.S1295S	MAST4_ENST00000403666.1_Silent_p.S1103S|MAST4_ENST00000403625.2_Silent_p.S1292S|MAST4_ENST00000261569.7_Silent_p.S1098S|MAST4_ENST00000405643.1_Silent_p.S1113S			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	1295	Ser-rich.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GATCCCTGTCATCGGGTGAGA	0.537000													21	40					0	0	1	0	0
NT5C2	22978	broad.mit.edu	37	10	104934622	104934622	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr10:104934622A>T	ENST00000343289.5	-	2	181	c.94T>A	c.(94-96)Tat>Aat	p.Y32N	NT5C2_ENST00000470299.1_Missense_Mutation_p.Y32N|NT5C2_ENST00000404739.3_Missense_Mutation_p.Y32N|NT5C2_ENST00000369857.4_Intron	NM_001134373.2|NM_012229.4	NP_001127845.1|NP_036361.1	P49902	5NTC_HUMAN	5'-nucleotidase, cytosolic II	32					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|metal ion binding|nucleotide binding|protein binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|urinary_tract(1)	16		all_hematologic(284;0.176)|Colorectal(252;0.178)		Epithelial(162;1.33e-08)|all cancers(201;1.04e-07)|BRCA - Breast invasive adenocarcinoma(275;0.159)	Adenosine triphosphate(DB00171)|Ribavirin(DB00811)	TACCGATGATAGGCTTCTCGA	0.383000													28	82					0	0	1	0	0
COLQ	8292	broad.mit.edu	37	3	15520493	15520493	+	Silent	SNP	T	T	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr3:15520493T>C	ENST00000383785.2	-	5	509	c.384A>G	c.(382-384)ccA>ccG	p.P128P	COLQ_ENST00000383787.2_Intron|COLQ_ENST00000383781.4_Silent_p.P118P|COLQ_ENST00000435459.2_Silent_p.P118P|COLQ_ENST00000383786.5_Silent_p.P94P|COLQ_ENST00000603808.1_Silent_p.P128P|COLQ_ENST00000383788.5_Silent_p.P128P			Q9Y215	COLQ_HUMAN	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	128	Collagen-like 1.				acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft				endometrium(2)|large_intestine(4)|lung(10)|skin(3)	19						CCTTCCTTCCTGGTCGGCCAA	0.537000													4	69					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169145434	169145434	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr4:169145434T>C	ENST00000393743.3	-	35	5075	c.4784A>G	c.(4783-4785)aAc>aGc	p.N1595S		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1595							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		ATCATCAAAGTTCCCAGACAG	0.368000													13	29					0	0	1	0	0
CCDC110	256309	broad.mit.edu	37	4	186380117	186380117	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr4:186380117C>T	ENST00000307588.3	-	6	1699	c.1624G>A	c.(1624-1626)Gca>Aca	p.A542T	CCDC110_ENST00000393540.3_Missense_Mutation_p.A505T|CCDC110_ENST00000510617.1_Missense_Mutation_p.A542T	NM_152775.3	NP_689988.1	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110	542						nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(9)	30		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TGATCTAATGCTTCCATCATT	0.274000													10	31					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152275641	152275641	+	Silent	SNP	G	G	A			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr1:152275641G>A	ENST00000368799.1	-	3	11756	c.11721C>T	c.(11719-11721)cgC>cgT	p.R3907R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3907	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCTGTATCGCGGTGAGAGG	0.502000									Ichthyosis				4	78					0	0	1	0	0
RC3H2	54542	broad.mit.edu	37	9	125652610	125652610	+	Silent	SNP	T	T	A			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr9:125652610T>A	ENST00000373670.1	-	3	1164	c.564A>T	c.(562-564)ggA>ggT	p.G188G	RC3H2_ENST00000478216.1_5'UTR|RC3H2_ENST00000373665.2_Silent_p.G188G|RC3H2_ENST00000357244.2_Silent_p.G188G|RC3H2_ENST00000423239.2_Silent_p.G188G|RC3H2_ENST00000335387.5_Silent_p.G188G|RC3H2_ENST00000471874.2_Silent_p.G188G			Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type domains 2	188						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|large_intestine(4)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						AAAACTGGCATCCTCGAGCCC	0.473000													4	39					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20476907	20476907	+	Missense_Mutation	SNP	T	T	G			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr16:20476907T>G	ENST00000573854.1	+	3	360	c.246T>G	c.(244-246)aaT>aaG	p.N82K	ACSM2A_ENST00000417235.2_Missense_Mutation_p.N3K|ACSM2A_ENST00000424070.1_Missense_Mutation_p.N82K|ACSM2A_ENST00000575690.1_Missense_Mutation_p.N82K|ACSM2A_ENST00000396104.2_Missense_Mutation_p.N82K|ACSM2A_ENST00000219054.6_Missense_Mutation_p.N82K|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000536134.1_De_novo_Start_InFrame	NM_001010845.2	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	82					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						TAATGTGGAATTTCAGAGAAC	0.597000													4	44					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43052756	43052756	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr20:43052756C>T	ENST00000316099.4	+	8	1080	c.991C>T	c.(991-993)Cgt>Tgt	p.R331C	HNF4A_ENST00000457232.1_Missense_Mutation_p.R309C|HNF4A_ENST00000609795.1_Missense_Mutation_p.R309C|HNF4A_ENST00000415691.2_Missense_Mutation_p.R331C|HNF4A_ENST00000443598.2_Missense_Mutation_p.R331C|HNF4A_ENST00000316673.4_Missense_Mutation_p.R309C	NM_000457.4|NM_001258355.1|NM_178849.2	NP_000448.3|NP_001245284.1|NP_849180.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha						blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding	p.R331G(2)|p.R309G(1)		endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GTATGACTCGCGTGGCCGCTT	0.592000													7	10					0	0	1	0	0
C20orf144	128864	broad.mit.edu	37	20	32251489	32251489	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr20:32251489T>C	ENST00000375222.3	+	2	340	c.278T>C	c.(277-279)aTg>aCg	p.M93T	NECAB3_ENST00000375238.4_Intron|NECAB3_ENST00000246190.6_Intron	NM_080825.3	NP_543015.1	Q9BQM9	CT144_HUMAN	chromosome 20 open reading frame 144	93										lung(1)	1						GAGCCGAGGATGCCGGTACTG	0.746000													3	2					0	0	1	0	0
CHEK1	1111	broad.mit.edu	37	11	125497608	125497608	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr11:125497608A>G	ENST00000534070.1	+	3	427	c.172A>G	c.(172-174)Atc>Gtc	p.I58V	CHEK1_ENST00000278916.3_Missense_Mutation_p.I58V|CHEK1_ENST00000427383.2_Intron|CHEK1_ENST00000438015.1_Missense_Mutation_p.I58V|CHEK1_ENST00000532449.1_Intron|CHEK1_ENST00000524737.1_Missense_Mutation_p.I58V|CHEK1_ENST00000428830.2_Missense_Mutation_p.I58V|CHEK1_ENST00000544373.1_Missense_Mutation_p.I58V	NM_001274.5	NP_001265.2	O14757	CHK1_HUMAN	checkpoint kinase 1	58	Protein kinase.				cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|endometrium(3)|large_intestine(2)|lung(16)|skin(1)|upper_aerodigestive_tract(1)	26	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		AGAGATCTGTATCAATAAAAT	0.363000								Other conserved DNA damage response genes					20	30					0	0	1	0	0
FAM217A	222826	broad.mit.edu	37	6	4069947	4069947	+	Silent	SNP	A	A	G			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr6:4069947A>G	ENST00000274673.3	-	7	913	c.510T>C	c.(508-510)tgT>tgC	p.C170C	FAM217A_ENST00000380188.2_5'UTR	NM_173563.2	NP_775834.2	Q8IXS0	CF146_HUMAN	family with sequence similarity 217, member A	170																	CTATAGTTGAACATGAACTAA	0.393000													30	35					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19839062	19839062	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr5:19839062C>T	ENST00000507958.1	-	5	1024	c.34G>A	c.(34-36)Gtc>Atc	p.V12I	CDH18_ENST00000382275.1_Missense_Mutation_p.V12I|CDH18_ENST00000511273.1_Missense_Mutation_p.V12I|CDH18_ENST00000502796.1_Missense_Mutation_p.V12I|CDH18_ENST00000506372.1_Missense_Mutation_p.V12I|CDH18_ENST00000274170.4_Missense_Mutation_p.V12I			Q13634	CAD18_HUMAN	cadherin 18, type 2	12					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CACACTAGGACTGGACAGATG	0.423000													21	39					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124288309	124288309	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr12:124288309A>G	ENST00000409039.3	+	16	2387	c.2362A>G	c.(2362-2364)Aca>Gca	p.T788A		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	788	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TTCCAGGCTGACATTAATAGA	0.413000													20	66					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35556561	35556561	+	Silent	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr19:35556561C>T	ENST00000262626.2	+	11	1851	c.1026C>T	c.(1024-1026)ccC>ccT	p.P342P	HPN_ENST00000597419.1_Silent_p.P184P|HPN_ENST00000392226.1_Silent_p.P342P|HPN-AS1_ENST00000392227.2_RNA	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	342	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	CTGGCTACCCCGAGGGTGGCA	0.597000													27	44					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185959534	185959534	+	Silent	SNP	T	T	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr1:185959534T>C	ENST00000271588.4	+	22	3565	c.3336T>C	c.(3334-3336)acT>acC	p.T1112T	HMCN1_ENST00000367492.2_Silent_p.T1112T|HMCN1_ENST00000485744.1_3'UTR	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1112	Ig-like C2-type 8.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CCATAATTACTTGGGCCAAAG	0.478000													44	48					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4091419	4091419	+	Silent	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr7:4091419C>T	ENST00000404826.2	+	19	3007	c.2868C>T	c.(2866-2868)gaC>gaT	p.D956D	SDK1_ENST00000389531.3_Silent_p.D956D	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	956	Fibronectin type-III 3.				cell adhesion	integral to membrane		p.D956D(1)		NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCCCTGGGGACGGGCCTCCCA	0.527000													30	40					0	0	1	0	0
DHX29	54505	broad.mit.edu	37	5	54573002	54573002	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr5:54573002C>T	ENST00000251636.5	-	13	2366	c.2218G>A	c.(2218-2220)Gaa>Aaa	p.E740K	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	740	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				GAAAATTTTTCGCTGTCCACA	0.363000													6	78					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117310638	117310638	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr11:117310638T>C	ENST00000321322.6	-	22	4058	c.4057A>G	c.(4057-4059)Atc>Gtc	p.I1353V	DSCAML1_ENST00000527706.1_Missense_Mutation_p.I1083V	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1293	Ig-like C2-type 10.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCAAAGGAGATGATCTTTGCT	0.557000													5	86					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108776215	108776215	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr3:108776215C>T	ENST00000232603.5	-	13	1232	c.1150G>A	c.(1150-1152)Ggc>Agc	p.G384S	MORC1_ENST00000483760.1_Missense_Mutation_p.G384S	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	384					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						AACTGTGAGCCCACTTTTTCA	0.403000													46	61					0	0	1	0	0
ZNF354A	6940	broad.mit.edu	37	5	178152410	178152410	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr5:178152410C>A	ENST00000335815.2	-	4	420	c.223G>T	c.(223-225)Gtg>Ttg	p.V75L		NM_005649.2	NP_005640.2	O60765	Z354A_HUMAN	zinc finger protein 354A	75	KRAB.				regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(7)|lung(3)|ovary(2)|skin(2)|stomach(2)	19	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		TCTTTCTCCACCTCCCAGGGA	0.507000													46	50					2.27781e-18	2.42017e-18	1	1	0
PTPRH	5794	broad.mit.edu	37	19	55716930	55716930	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr19:55716930T>C	ENST00000376350.3	-	4	405	c.383A>G	c.(382-384)gAg>gGg	p.E128G	PTPRH_ENST00000263434.5_Intron|PTPRH_ENST00000588559.1_5'UTR	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	128	Fibronectin type-III 2.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		GGTCTGAGCCTCCACTCTCAG	0.572000													16	32					0	0	1	0	0
DISP1	84976	broad.mit.edu	37	1	223176649	223176649	+	Missense_Mutation	SNP	C	C	T	rs148231227	by1000genomes	TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr1:223176649C>T	ENST00000284476.6	+	8	2074	c.1910C>T	c.(1909-1911)gCg>gTg	p.A637V		NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	637	SSD.				diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity	p.A637V(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		GGGGTTTATGCGGGGACAGCT	0.448000													5	180					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17696859	17696859	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr2:17696859A>T	ENST00000399080.2	-	1	2847	c.2824T>A	c.(2824-2826)Tgt>Agt	p.C942S		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	942										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TCCTGAAAACATTCATCATTC	0.318000													14	29					0	0	1	0	0
SPRR1B	6699	broad.mit.edu	37	1	153004933	153004933	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr1:153004933A>G	ENST00000307098.4	+	2	177	c.112A>G	c.(112-114)Aag>Gag	p.K38E	SPRR1B_ENST00000392661.3_Missense_Mutation_p.K38E	NM_003125.2	NP_003116.2	P22528	SPR1B_HUMAN	small proline-rich protein 1B	38	6 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|ovary(2)|skin(2)	9	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCCCAAAACCAAGGAGCCCTG	0.642000													6	95					0	0	1	0	0
FUCA2	2519	broad.mit.edu	37	6	143818531	143818531	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr6:143818531T>C	ENST00000002165.6	-	6	1313	c.1258A>G	c.(1258-1260)Aca>Gca	p.T420A	RP1-20N2.6_ENST00000610068.1_RNA|RP1-20N2.6_ENST00000589563.1_RNA|FUCA2_ENST00000438118.2_3'UTR|RP1-20N2.6_ENST00000591892.1_RNA	NM_032020.4	NP_114409.2	Q9BTY2	FUCO2_HUMAN	fucosidase, alpha-L- 2, plasma						fucose metabolic process	extracellular region	alpha-L-fucosidase activity|cation binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				OV - Ovarian serous cystadenocarcinoma(155;7.45e-06)|GBM - Glioblastoma multiforme(68;0.0142)		CTTACCTCTGTTGCCCCCAGA	0.393000													22	26					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21713428	21713428	+	Splice_Site	SNP	T	T	C			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr12:21713428T>C	ENST00000261195.2	-	8	1317		c.e8-2			NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)						glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						TTTATGCATCTGATGAGGAAT	0.328000													40	56					0	0	1	0	0
PTH2R	5746	broad.mit.edu	37	2	209358134	209358135	+	Frame_Shift_Ins	INS	-	-	CACA			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr2:209358134_209358135insCACA	ENST00000272847.2	+	13	1616_1617	c.1403_1404insCACA	c.(1402-1407)agcacafs	p.-469fs	AC019185.4_ENST00000424628.1_RNA|PTH2R_ENST00000413482.1_3'UTR	NM_005048.2	NP_005039.1	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor							integral to plasma membrane	parathyroid hormone receptor activity	p.S468N(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(21)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		GTGGCGGCCAGCACACGCATGG	0.594													7	18	---	---	---	---					
HSPD1P6	645548	broad.mit.edu	37	3	36810381	36810381	+	RNA	DEL	T	T	-			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr3:36810381delT	ENST00000424886.1	-	0	405																											GAGTGAGGCCttttttttttt	0.542													3	4	---	---	---	---					
TDRP	157695	broad.mit.edu	37	8	494659	494664	+	In_Frame_Del	DEL	GGCGGC	GGCGGC	-	rs71202629		TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr8:494659_494664delGGCGGC	ENST00000324079.6	-	1	334_339	c.94_99delGCCGCC	c.(94-99)gccgccdel	p.AA32del	TDRP_ENST00000427263.2_In_Frame_Del_p.AA32del|TDRP_ENST00000523656.1_In_Frame_Del_p.AA32del					testis development related protein									p.A32_A33delAA(1)									CCTGCGCCTGggcggcggcggcggcg	0.782													6	7	---	---	---	---					
KRT76	51350	broad.mit.edu	37	12	53162773	53162775	+	In_Frame_Del	DEL	ACT	ACT	-	rs1464423	by1000genomes	TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr12:53162773_53162775delACT	ENST00000332411.2	-	9	1692_1694	c.1639_1641delAGT	c.(1639-1641)agtdel	p.S547del		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	547	Tail.				cytoskeleton organization	keratin filament	structural molecule activity	p.S547_G548insS(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						ctccatagccactgctgctgctg	0.635													2	4	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7577049	7577049	+	Frame_Shift_Del	DEL	G	G	-			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr17:7577049delG	ENST00000420246.2	-	8	1021	c.889delC	c.(889-891)cacfs	p.H297fs	TP53_ENST00000269305.4_Frame_Shift_Del_p.H297fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.H297fs|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Frame_Shift_Del_p.H297fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.H297fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	297	Interaction with HIPK1 (By similarity).		H -> D (in a sporadic cancer; somatic mutation).|H -> N (in a sporadic cancer; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K291fs*48(8)|p.0?(8)|p.H297Y(5)|p.?(2)|p.H297N(1)|p.L265_K305del41(1)|p.G293fs*1(1)|p.H296_S303delHHELPPGS(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAGCTCGTGGTGAGGCTCC	0.562		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	28	---	---	---	---					
C21orf33	8209	broad.mit.edu	37	21	45553593	45553593	+	Frame_Shift_Del	DEL	G	G	-			TCGA-S9-A89Z-01A-11D-A36O-08	TCGA-S9-A89Z-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	860048e0-8766-4089-81ab-b7e78c3ce37d	ce476398-3d8b-450d-a658-6ed2f06408b0	g.chr21:45553593delG	ENST00000291577.6	+	1	107	c.14delG	c.(13-15)aggfs	p.R5fs	C21orf33_ENST00000348499.5_Frame_Shift_Del_p.R5fs|C21orf33_ENST00000493883.1_3'UTR|C21orf33_ENST00000427803.2_Frame_Shift_Del_p.R5fs	NM_004649.6	NP_004640	P30042	ES1_HUMAN	chromosome 21 open reading frame 33	5						mitochondrion				NS(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8				STAD - Stomach adenocarcinoma(101;0.168)|Colorectal(79;0.191)		GCGGCTGTGAGGGTCCTGGTG	0.687													2	4	---	---	---	---					
