Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZMYND15	84225	broad.mit.edu	37	17	4644908	4644908	+	Missense_Mutation	SNP	A	A	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr17:4644908A>T	ENST00000433935.1	+	3	681	c.624A>T	c.(622-624)ttA>ttT	p.L208F	ZMYND15_ENST00000269289.6_Missense_Mutation_p.L208F|ZMYND15_ENST00000573751.2_Missense_Mutation_p.L208F|ZMYND15_ENST00000592813.1_Missense_Mutation_p.L208F	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15	208							zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						CCTGTCTCTTACTTGTGACGG	0.582000													7	321					0	0	1	0	0
HIST1H2BE	8344	broad.mit.edu	37	6	26184184	26184184	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr6:26184184G>A	ENST00000356530.3	+	1	227	c.161G>A	c.(160-162)gGc>gAc	p.G54D		NM_003523.2	NP_003514.2	P62807	H2B1C_HUMAN	histone cluster 1, H2be	54					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			endometrium(1)|large_intestine(2)|lung(1)	4						CCCGACACCGGCATCTCCTCT	0.577000													5	288					0	0	1	0	0
FLOT2	2319	broad.mit.edu	37	17	27207790	27207790	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr17:27207790G>A	ENST00000394906.2	-	12	1431	c.1354C>T	c.(1354-1356)Cga>Tga	p.R452*	FLOT2_ENST00000394908.4_Nonsense_Mutation_p.R397*|FLOT2_ENST00000585169.1_Nonsense_Mutation_p.R397*|FLOT2_ENST00000577789.1_5'UTR			Q14254	FLOT2_HUMAN	flotillin 2	397					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction				endometrium(3)|lung(6)|prostate(1)|urinary_tract(1)	11	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			GCCAGCAGTCGGTTCACTTCT	0.572000													11	100					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296282	39296282	+	Missense_Mutation	SNP	G	G	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr17:39296282G>T	ENST00000345847.4	-	1	457	c.458C>A	c.(457-459)tCt>tAt	p.S153Y		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	149	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						ttcacagcaagaggggcggca	0.662000													5	60					0.0215528	0.0224508	1	1	0
FRG1B	284802	broad.mit.edu	37	20	29628245	29628245	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr20:29628245G>A	ENST00000278882.3	+	6	627	c.247G>A	c.(247-249)Gcc>Acc	p.A83T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A83T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A88T														p.A83T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTTTGTTGGCCTCAAATAG	0.353000													6	206					0	0	1	0	0
CYHR1	50626	broad.mit.edu	37	8	145690245	145690245	+	Missense_Mutation	SNP	A	A	C			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr8:145690245A>C	ENST00000438911.2	-	1	173	c.40T>G	c.(40-42)Tcc>Gcc	p.S14A	CTD-2517M22.16_ENST00000525461.1_RNA|CYHR1_ENST00000424149.2_Missense_Mutation_p.S14A|CYHR1_ENST00000403000.2_Missense_Mutation_p.S14A|CYHR1_ENST00000306145.5_Missense_Mutation_p.S14A	NM_138496.1	NP_612505.1	Q6ZMK1	CYHR1_HUMAN	cysteine/histidine-rich 1	14						perinuclear region of cytoplasm	zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(3)|ovary(2)	7	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			ACCAGATGGGACAGGGCTGTG	0.622000													10	34					0	0	1	0	0
AOC3	8639	broad.mit.edu	37	17	41004014	41004014	+	Silent	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr17:41004014G>A	ENST00000308423.2	+	1	814	c.654G>A	c.(652-654)ctG>ctA	p.L218L		NM_003734.2	NP_003725.1	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3	218					amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			breast(1)|central_nervous_system(4)|endometrium(4)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|skin(8)	41		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	CCCGTGGTCTGCAATCAGGGG	0.607000													26	69					0	0	1	0	0
TRBV6-8	28599	broad.mit.edu	37	7	142124387	142124387	+	RNA	SNP	T	T	C			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr7:142124387T>C	ENST00000390376.2	-	0	90																											GTCTTCAGGATGTGGAATTTT	0.522000													4	145					0	0	1	0	0
CDC123	8872	broad.mit.edu	37	10	12238281	12238281	+	Missense_Mutation	SNP	G	G	C			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr10:12238281G>C	ENST00000281141.4	+	1	317	c.37G>C	c.(37-39)Gcg>Ccg	p.A13P	CDC123_ENST00000455773.3_3'UTR|CDC123_ENST00000378900.2_Missense_Mutation_p.A13P	NM_006023.2	NP_006014.2	O75794	CD123_HUMAN	cell division cycle 123	13					cell cycle arrest|cell division|positive regulation of cell proliferation|regulation of mitotic cell cycle	cytoplasm				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12						CCAGTTCTCCGCGTGGTACCC	0.622000													10	142					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25836841	25836841	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr4:25836841G>A	ENST00000399878.3	-	3	960	c.838C>T	c.(838-840)Cgc>Tgc	p.R280C	SEL1L3_ENST00000502949.1_Missense_Mutation_p.R127C|SEL1L3_ENST00000264868.5_Missense_Mutation_p.R245C|SEL1L3_ENST00000513364.1_5'UTR	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	280						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						ATCCTCTGGCGTCGAGTGGCC	0.537000													15	224					0	0	1	0	0
CCDC153	283152	broad.mit.edu	37	11	119061065	119061065	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr11:119061065G>A	ENST00000503566.2	-	6	576	c.577C>T	c.(577-579)Cgc>Tgc	p.R193C	CCDC153_ENST00000415318.1_Missense_Mutation_p.R193C			Q494R4	CC153_HUMAN	coiled-coil domain containing 153	193										lung(3)|stomach(1)	4						CCAAACTGGCGTTGCTGCTCC	0.572000													59	94					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55111566	55111566	+	Missense_Mutation	SNP	A	A	G			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr11:55111566A>G	ENST00000314721.2	+	1	940	c.890A>G	c.(889-891)aAa>aGa	p.K297R		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						AATGCTATGAAAAATCTCTGG	0.313000													23	36					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578413	7578413	+	Missense_Mutation	SNP	C	C	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr17:7578413C>A	ENST00000420246.2	-	5	649	c.517G>T	c.(517-519)Gtg>Ttg	p.V173L	TP53_ENST00000574684.1_5'UTR|TP53_ENST00000455263.2_Missense_Mutation_p.V173L|TP53_ENST00000269305.4_Missense_Mutation_p.V173L|TP53_ENST00000359597.4_Missense_Mutation_p.V173L|TP53_ENST00000413465.2_Missense_Mutation_p.V173L|TP53_ENST00000445888.2_Missense_Mutation_p.V173L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	173	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		V -> A (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> M (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V173L(68)|p.V173M(46)|p.0?(8)|p.V80L(6)|p.V41L(6)|p.V173fs*1(4)|p.V80M(3)|p.V41M(3)|p.V173fs*59(2)|p.V157_C176del20(1)|p.V172_R174delVVR(1)|p.V173fs*69(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.E171fs*1(1)|p.V173W(1)|p.V173fs*8(1)|p.H168fs*69(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCCTCACAACCTCCGTC	0.662000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			78	17					9.35349e-44	1.15002e-43	1	1	0
KIAA1210	57481	broad.mit.edu	37	X	118222263	118222263	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chrX:118222263G>A	ENST00000402510.2	-	11	2929	c.2930C>T	c.(2929-2931)tCt>tTt	p.S977F		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	977										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						AGGCTTCATAGAAATGCTCTC	0.463000													31	6					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7635291	7635291	+	Silent	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr12:7635291G>A	ENST00000359156.4	-	14	3397	c.3195C>T	c.(3193-3195)ttC>ttT	p.F1065F	CD163_ENST00000432237.2_Silent_p.F1065F|CD163_ENST00000396620.3_Silent_p.F1098F|CD163_ENST00000541972.1_Silent_p.F1053F	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	1065					acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						ATAATGCGACGAAAATGGCCA	0.423000													9	204					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56418203	56418203	+	Missense_Mutation	SNP	T	T	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr6:56418203T>A	ENST00000370754.5	-	61	15293	c.15294A>T	c.(15292-15294)caA>caT	p.Q5098H	DST_ENST00000421834.2_Missense_Mutation_p.Q2832H|DST_ENST00000370788.2_Missense_Mutation_p.Q2832H|DST_ENST00000370769.4_Missense_Mutation_p.Q4920H|DST_ENST00000446842.2_Missense_Mutation_p.Q4594H|DST_ENST00000312431.6_3'UTR|DST_ENST00000361203.3_Missense_Mutation_p.Q4918H|DST_ENST00000244364.6_Missense_Mutation_p.Q2506H			Q03001	DYST_HUMAN	dystonin	4918					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCTCAGACCCTTGTGTTTTTA	0.318000													4	98					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96525640	96525640	+	Missense_Mutation	SNP	G	G	T	rs77864759		TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr2:96525640G>T	ENST00000456556.1	-	61	3949	c.3865C>A	c.(3865-3867)Ctt>Att	p.L1289I	ANKRD36C_ENST00000420871.2_Missense_Mutation_p.L540I|ANKRD36C_ENST00000419039.2_Missense_Mutation_p.L316I					ankyrin repeat domain 36C											breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCCAATTCAAGTGTTTCATGC	0.284000													3	20					0.150653	0.152689	1	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													5	24					0	0	1	0	0
SART3	9733	broad.mit.edu	37	12	108920291	108920291	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr12:108920291G>A	ENST00000228284.3	-	16	2189	c.1955C>T	c.(1954-1956)cCt>cTt	p.P652L	SART3_ENST00000431469.2_Missense_Mutation_p.P616L	NM_014706.3	NP_055521.1	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T cells 3	652	Required for nuclear localization.				RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|stomach(1)	25						TCCAGCTGCAGGGATGCTGTT	0.507000									Porokeratosis				7	149					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102304793	102304793	+	RNA	SNP	A	A	C			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr15:102304793A>C	ENST00000561463.1	+	0	12839																											GCGTGGGAAGAAGAAGACACT	0.592000													5	24					0	0	1	0	0
OR10H4	126541	broad.mit.edu	37	19	16059822	16059822	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr19:16059822C>T	ENST00000322107.1	+	1	5	c.5C>T	c.(4-6)cCt>cTt	p.P2L		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						GTATCCATGCCTAGTCAGAAC	0.438000													6	94					0	0	1	0	0
OR2A7	401427	broad.mit.edu	37	7	143956629	143956629	+	Silent	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr7:143956629G>A	ENST00000493325.1	-	1	186	c.93C>T	c.(91-93)tcC>tcT	p.S31S	OR2A1-AS1_ENST00000461843.1_RNA|OR2A1-AS1_ENST00000489488.1_RNA|RP4-545C24.1_ENST00000460955.1_RNA|OR2A1-AS1_ENST00000463561.1_RNA|OR2A1-AS1_ENST00000478806.1_RNA|OR2A1-AS1_ENST00000476560.1_RNA|ARHGEF35_ENST00000543357.1_Intron|OR2A1-AS1_ENST00000487102.1_RNA	NM_001005328.1	NP_001005328.1	Q96R45	OR2A7_HUMAN	olfactory receptor, family 2, subfamily A, member 7	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)	6	Melanoma(164;0.14)					CGTAGAACAGGGAGAAGAGCC	0.537000													10	263					0	0	1	0	0
CYP2E1	1571	broad.mit.edu	37	10	135352317	135352317	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr10:135352317G>A	ENST00000463117.2	+	11	1603	c.1331G>A	c.(1330-1332)cGc>cAc	p.R444H	CYP2E1_ENST00000252945.3_Missense_Mutation_p.R444H|SPRN_ENST00000541506.1_Intron			P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E, polypeptide 1	444					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			NS(1)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(7)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	GGCCTGGCTCGCATGGAGTTG	0.448000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				8	493					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	3974138	3974138	+	Silent	SNP	C	C	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr17:3974138C>A	ENST00000381638.2	-	26	4039	c.3915G>T	c.(3913-3915)ggG>ggT	p.G1305G		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	1305							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						CTGAATATGGCCCACAGAAGT	0.438000													61	93					4.96213e-28	5.9073e-28	1	1	0
ZNF607	84775	broad.mit.edu	37	19	38189657	38189657	+	Missense_Mutation	SNP	G	G	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr19:38189657G>T	ENST00000355202.4	-	5	1970	c.1375C>A	c.(1375-1377)Cgt>Agt	p.R459S	CTD-2528L19.4_ENST00000586606.2_Intron|ZNF607_ENST00000395835.3_Missense_Mutation_p.R458S	NM_032689.4	NP_116078.4	Q96SK3	ZN607_HUMAN	zinc finger protein 607	459					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|lung(8)|urinary_tract(1)	27			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			GAGGCACAACGAAAGGACTTC	0.413000													5	110					1	1	1	1	0
ADPRHL1	113622	broad.mit.edu	37	13	114107558	114107558	+	Silent	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr13:114107558G>A	ENST00000375418.3	-	1	281	c.195C>T	c.(193-195)acC>acT	p.T65T		NM_138430.3	NP_612439.2	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1	65					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	11	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			GGGCCTCGGCGGTTGCGATGT	0.647000													41	17					0	0	1	0	0
FTCD	10841	broad.mit.edu	37	21	47557244	47557244	+	Missense_Mutation	SNP	G	G	A	rs145609043		TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr21:47557244G>A	ENST00000397748.1	-	13	1491	c.1448C>T	c.(1447-1449)gCg>gTg	p.A483V	FTCD_ENST00000355384.2_Silent_p.G468G|FTCD_ENST00000498355.2_5'UTR|FTCD_ENST00000397746.3_Missense_Mutation_p.A483V|FTCD_ENST00000397743.1_Silent_p.G468G|FTCD_ENST00000291670.5_Missense_Mutation_p.A483V|FTCD_ENST00000359679.2_Missense_Mutation_p.A483V			O95954	FTCD_HUMAN	formimidoyltransferase cyclodeaminase	483	Cyclodeaminase/cyclohydrolase (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			endometrium(1)|large_intestine(2)|lung(9)|pancreas(1)|prostate(3)|skin(3)	19	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	GGCTTTGGCCGCCACCTGCAA	0.597000													32	23					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21236129	21236129	+	Nonsense_Mutation	SNP	G	G	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr2:21236129G>T	ENST00000233242.1	-	25	4246	c.4119C>A	c.(4117-4119)taC>taA	p.Y1373*		NM_000384.2	NP_000375	P04114	APOB_HUMAN	apolipoprotein B	1373					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGCCACCACTGTAGGAGGCGG	0.512000													10	214					0.0135373	0.0143	1	1	0
LAMA2	3908	broad.mit.edu	37	6	129419488	129419488	+	Silent	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr6:129419488G>A	ENST00000421865.2	+	4	616	c.567G>A	c.(565-567)ccG>ccA	p.P189P		NM_000426.3|NM_001079823.1	NP_000417|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	189	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTGGGCCACCGTCATATGCCA	0.448000													29	53					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10445137	10445137	+	Missense_Mutation	SNP	C	C	G			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr4:10445137C>G	ENST00000326756.3	-	3	3254	c.2816G>C	c.(2815-2817)cGg>cCg	p.R939P		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	939					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						TGGCTGGTTCCGACGGGGACA	0.448000													7	174					0	0	1	0	0
GSTK1	373156	broad.mit.edu	37	7	142965221	142965221	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr7:142965221G>A	ENST00000479303.1	+	6	801	c.743G>A	c.(742-744)gGc>gAc	p.G248D	GSTK1_ENST00000409500.3_Missense_Mutation_p.G180D|GSTK1_ENST00000358406.5_Missense_Mutation_p.G192D|AC073342.12_ENST00000427392.1_RNA|GSTK1_ENST00000443571.2_Missense_Mutation_p.G149D	NM_001143679.1	NP_001137151.1	Q9Y2Q3	GSTK1_HUMAN	glutathione S-transferase kappa 1	192						outer membrane-bounded periplasmic space|peroxisome	glutathione transferase activity|identical protein binding|protein disulfide oxidoreductase activity			lung(4)	4	Melanoma(164;0.059)				Glutathione(DB00143)	CATGTGGATGGCCAAACCCAC	0.547000													7	800					0	0	1	0	0
SEMA4F	10505	broad.mit.edu	37	2	74901641	74901641	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr2:74901641G>A	ENST00000357877.2	+	8	988	c.839G>A	c.(838-840)cGg>cAg	p.R280Q	SEMA4F_ENST00000339773.5_Missense_Mutation_p.R125Q	NM_004263.3	NP_004254.2	O95754	SEM4F_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F	280	Sema.				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			biliary_tract(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	45						CTCGGGGGCCGGAAGACCCTC	0.562000													20	43					0	0	1	0	0
AQR	9716	broad.mit.edu	37	15	35193058	35193058	+	Silent	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr15:35193058G>A	ENST00000156471.5	-	20	2233	c.2008C>T	c.(2008-2010)Ctg>Ttg	p.L670L		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	670						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		ATAGTCTCCAGCACAGCCTGT	0.438000													4	90					0	0	1	0	0
IP6K2	51447	broad.mit.edu	37	3	48725944	48725944	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr3:48725944T>C	ENST00000328631.5	-	6	1266	c.1043A>G	c.(1042-1044)gAt>gGt	p.D348G		NM_001005909.2|NM_016291.3	NP_001005909.1|NP_057375.2	Q9UHH9	IP6K2_HUMAN	inositol hexakisphosphate kinase 2	348					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	15						ATCCTCAGCATCTGAGTCCAG	0.557000													13	33					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76849196	76849196	+	Missense_Mutation	SNP	A	A	G			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chrX:76849196A>G	ENST00000373344.5	-	26	6294	c.6080T>C	c.(6079-6081)cTt>cCt	p.L2027P	ATRX_ENST00000395603.3_Missense_Mutation_p.L1989P|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.3	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	2027	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TGCCATTCGAAGAATTTCAAA	0.348000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						47	24					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								44	58					0	0	1	0	0
PRDM12	59335	broad.mit.edu	37	9	133553963	133553963	+	Missense_Mutation	SNP	C	C	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr9:133553963C>A	ENST00000253008.2	+	4	678	c.618C>A	c.(616-618)caC>caA	p.H206Q		NM_021619.2	NP_067632.2	Q9H4Q4	PRD12_HUMAN	PR domain containing 12	206	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		GAAACTCACACAACACCTTCC	0.592000													4	93					0.00024832	0.00027797	1	1	0
COL4A6	1288	broad.mit.edu	37	X	107417809	107417809	+	Missense_Mutation	SNP	G	G	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chrX:107417809G>T	ENST00000334504.7	-	31	3232	c.2999C>A	c.(2998-3000)cCt>cAt	p.P1000H	COL4A6_ENST00000372216.4_Missense_Mutation_p.P1001H|COL4A6_ENST00000545689.1_Missense_Mutation_p.P1000H|COL4A6_ENST00000394872.2_Missense_Mutation_p.P1001H|COL4A6_ENST00000538570.1_Missense_Mutation_p.P1000H	NM_033641.2	NP_378667.1	Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	1001	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						AGGAGCTCCAGGTAGGCCTGG	0.547000									Alport syndrome with Diffuse Leiomyomatosis				17	20					0.000566183	0.000624467	1	1	0
SLC39A10	57181	broad.mit.edu	37	2	196582986	196582986	+	Silent	SNP	C	C	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr2:196582986C>T	ENST00000409086.3	+	8	2351	c.2076C>T	c.(2074-2076)ttC>ttT	p.F692F	SLC39A10_ENST00000359634.5_Silent_p.F692F|SLC39A10_ENST00000541054.1_Silent_p.F242F	NM_001127257.1	NP_001120729.1	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter), member 10	692					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(16)|pancreas(1)|prostate(1)|skin(2)	34			OV - Ovarian serous cystadenocarcinoma(117;0.221)			GTGCAGCTTTCAGTGCTGGAT	0.363000													24	73					0	0	1	0	0
NOL8	55035	broad.mit.edu	37	9	95081532	95081532	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr9:95081532C>T	ENST00000545558.1	-	5	880	c.388G>A	c.(388-390)Gtg>Atg	p.V130M	NOL8_ENST00000358855.4_Missense_Mutation_p.V62M|NOL8_ENST00000535387.1_Missense_Mutation_p.V130M|NOL8_ENST00000442668.2_Missense_Mutation_p.V130M|NOL8_ENST00000542053.1_Missense_Mutation_p.V62M			Q76FK4	NOL8_HUMAN	nucleolar protein 8	130					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						GTCCCTGGCACAGCTTTCATA	0.468000													16	30					0	0	1	0	0
CTSB	1508	broad.mit.edu	37	8	11705211	11705211	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr8:11705211G>A	ENST00000353047.6	-	7	906	c.653C>T	c.(652-654)aCc>aTc	p.T218I	CTSB_ENST00000415599.2_3'UTR|CTSB_ENST00000453527.2_Missense_Mutation_p.T218I|CTSB_ENST00000530640.2_Missense_Mutation_p.T218I|CTSB_ENST00000533455.1_Missense_Mutation_p.T218I|CTSB_ENST00000345125.3_Missense_Mutation_p.T218I|CTSB_ENST00000434271.1_Missense_Mutation_p.T218I|CTSB_ENST00000531089.1_Missense_Mutation_p.T218I|CTSB_ENST00000534510.1_Missense_Mutation_p.T218I	NM_001908.3	NP_001899.1	P07858	CATB_HUMAN	cathepsin B	218					proteolysis|regulation of apoptosis|regulation of catalytic activity	lysosome|melanosome	cysteine-type endopeptidase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(1)	16	all_epithelial(15;0.205)		STAD - Stomach adenocarcinoma(15;0.00546)	COAD - Colon adenocarcinoma(149;0.184)		CTGTTTGTAGGTCGGGCTGTA	0.657000													53	141					0	0	1	0	0
CENPJ	55835	broad.mit.edu	37	13	25486740	25486740	+	Missense_Mutation	SNP	G	G	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr13:25486740G>T	ENST00000381884.4	-	2	609	c.424C>A	c.(424-426)Ctt>Att	p.L142I	CENPJ_ENST00000545981.1_Missense_Mutation_p.L142I	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	142					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		TTTTTAAAAAGTGGGTCTTTA	0.388000													8	94					0.0809354	0.0831528	1	1	0
FAM178A	55719	broad.mit.edu	37	10	102698451	102698451	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr10:102698451C>T	ENST00000238961.4	+	11	3154	c.2612C>T	c.(2611-2613)cCc>cTc	p.P871L	FAM178A_ENST00000370269.3_Missense_Mutation_p.P871L	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A																		TCTTTGTTTCCCCTGGAGAAT	0.368000													12	159					0	0	1	0	0
RIPK1	8737	broad.mit.edu	37	6	3083466	3083466	+	Missense_Mutation	SNP	G	G	A	rs149432620	byFrequency	TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr6:3083466G>A	ENST00000259808.4	+	5	905	c.607G>A	c.(607-609)Gca>Aca	p.A203T	RIPK1_ENST00000479389.1_3'UTR|RIPK1_ENST00000541791.1_Missense_Mutation_p.A157T|RIPK1_ENST00000380409.2_Missense_Mutation_p.A203T			Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine kinase 1	203	Protein kinase.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				TGACGTCAACGCAAAGCCCAC	0.488000													4	88					0	0	1	0	0
HOXA11	3207	broad.mit.edu	37	7	27222531	27222531	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr7:27222531G>A	ENST00000006015.3	-	2	897	c.826C>T	c.(826-828)Cgc>Tgc	p.R276C		NM_005523.5	NP_005514.1	P31270	HXA11_HUMAN	homeobox A11	276					branching involved in ureteric bud morphogenesis|cartilage development involved in endochondral bone morphogenesis|developmental growth|dorsal/ventral pattern formation|mesodermal cell fate specification|positive regulation of cell development|positive regulation of chondrocyte differentiation	protein-DNA complex|transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R276S(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)	16						TTGAGCATGCGGGACAGTTGC	0.458000			T	NUP98	CML								4	172					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55111605	55111605	+	Missense_Mutation	SNP	G	G	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr11:55111605G>T	ENST00000314721.2	+	1	979	c.929G>T	c.(928-930)aGa>aTa	p.R310I		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						GTTAGAAAAAGAGTATCTCCC	0.348000													15	35					1.15088e-07	1.32794e-07	1	1	0
KRTAP10-4	386672	broad.mit.edu	37	21	45993836	45993836	+	Silent	SNP	C	C	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr21:45993836C>T	ENST00000400374.3	+	1	231	c.201C>T	c.(199-201)tgC>tgT	p.C67C	TSPEAR_ENST00000323084.4_Intron	NM_198687.1	NP_941960.1	P60372	KR104_HUMAN	keratin associated protein 10-4	67	36 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(1)	18						CCAGCCCCTGCTGCCCAGTGA	0.711000													23	139					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S|FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													6	203					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48117859	48117859	+	Silent	SNP	A	A	G			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr16:48117859A>G	ENST00000311303.3	-	28	4299	c.3954T>C	c.(3952-3954)gtT>gtC	p.V1318V	ABCC12_ENST00000416054.1_3'UTR|ABCC12_ENST00000448542.1_3'UTR	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	1318	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				CGCAGTTGAGAACTGTGTTGA	0.512000													42	57					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9072517	9072517	+	Missense_Mutation	SNP	G	G	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr19:9072517G>T	ENST00000397910.4	-	3	15132	c.14929C>A	c.(14929-14931)Caa>Aaa	p.Q4977K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4979	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGACCTGTTTGGGTGGTGATG	0.483000													23	66					3.62473e-10	4.24773e-10	1	1	0
OR51S1	119692	broad.mit.edu	37	11	4869860	4869860	+	Silent	SNP	A	A	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr11:4869860A>T	ENST00000322101.2	-	1	654	c.579T>A	c.(577-579)gcT>gcA	p.A193A	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	193					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGGCCAAACGAGCCACATCTG	0.557000													8	68					0	0	1	0	0
TMEM26	219623	broad.mit.edu	37	10	63170316	63170316	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr10:63170316C>T	ENST00000399298.3	-	6	1239	c.871G>A	c.(871-873)Gcg>Acg	p.A291T	TMEM26_ENST00000507507.1_5'UTR	NM_178505.6	NP_848600.2	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	291						integral to membrane				kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	18	Prostate(12;0.0112)					AAGTTCTTCGCGGCAAAGAAC	0.512000													26	48					0	0	1	0	0
STRADB	55437	broad.mit.edu	37	2	202323545	202323545	+	Silent	SNP	C	C	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr2:202323545C>A	ENST00000194530.3	+	3	416	c.51C>A	c.(49-51)ctC>ctA	p.L17L	STRADB_ENST00000392249.2_Silent_p.L17L|STRADB_ENST00000488196.1_3'UTR	NM_001206864.1|NM_018571.5	NP_001193793.1|NP_061041.2	Q9C0K7	STRAB_HUMAN	STE20-related kinase adaptor beta	17					activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|protein binding|protein kinase activity			breast(1)|large_intestine(2)|lung(5)|prostate(1)|skin(3)|stomach(1)	13						TTGAATCACTCAGACCTGAAA	0.408000													13	201					5.50884e-06	6.26004e-06	1	1	0
CDKN2A	1029	broad.mit.edu	37	9	21971029	21971029	+	Nonsense_Mutation	SNP	C	C	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr9:21971029C>T	ENST00000304494.5	-	2	599	c.329G>A	c.(328-330)tGg>tAg	p.W110*	RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000361570.3_Silent_p.L165L|CDKN2A_ENST00000498628.2_Nonsense_Mutation_p.W59*|CDKN2A_ENST00000479692.2_Nonsense_Mutation_p.W59*|CDKN2A_ENST00000579755.1_Silent_p.L124L|CDKN2A_ENST00000530628.2_Silent_p.L124L|CDKN2A_ENST00000578845.2_Nonsense_Mutation_p.W59*|CDKN2A_ENST00000494262.1_Nonsense_Mutation_p.W59*|CDKN2A_ENST00000498124.1_Nonsense_Mutation_p.W110*|CDKN2A_ENST00000579122.1_Nonsense_Mutation_p.W110*|CDKN2A_ENST00000446177.1_Nonsense_Mutation_p.W110*|CDKN2A_ENST00000497750.1_Nonsense_Mutation_p.W59*	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	110					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(44)|p.W110*(13)|p.L165L(2)|p.H83fs*2(2)|p.D105fs*8(1)|p.0(1)|p.A68fs*3(1)|p.R107fs*33(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CAGACGGCCCCAGGCATCGCG	0.731000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			6	44					0	0	1	0	0
ZNF668	79759	broad.mit.edu	37	16	31072792	31072792	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr16:31072792C>T	ENST00000538906.1	-	3	2241	c.1457G>A	c.(1456-1458)tGc>tAc	p.C486Y	ZNF668_ENST00000539836.3_Missense_Mutation_p.C509Y|ZNF668_ENST00000535577.1_Missense_Mutation_p.C486Y|ZNF668_ENST00000300849.4_Missense_Mutation_p.C486Y|ZNF668_ENST00000394983.2_Missense_Mutation_p.C486Y|ZNF668_ENST00000426488.2_Missense_Mutation_p.C509Y	NM_001172668.1	NP_001166139	Q96K58	ZN668_HUMAN	zinc finger protein 668	486					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						AGCATCTTGGCATTCCACATG	0.672000													39	76					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149489293	149489293	+	RNA	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr7:149489293G>A	ENST00000378016.2	+	0	5538							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCGGCAGCCCGGGTAAGGGGG	0.672000													5	24					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140281990	140281990	+	Silent	SNP	C	C	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr3:140281990C>T	ENST00000458420.3	+	15	2617	c.2427C>T	c.(2425-2427)ccC>ccT	p.P809P		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	809					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						TGCAGCCTCCCTTCCTCCAGT	0.542000										HNSCC(16;0.037)			9	104					0	0	1	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115609945	115609945	+	Nonsense_Mutation	SNP	C	C	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr10:115609945C>A	ENST00000361384.2	-	2	1836	c.919G>T	c.(919-921)Gaa>Taa	p.E307*	DCLRE1A_ENST00000369305.1_Nonsense_Mutation_p.E307*	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	307					cell division|mitosis	nucleus	hydrolase activity	p.E307*(1)		breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		TGAGTGTCTTCATCACTTTGA	0.398000								Other identified genes with known or suspected DNA repair function					65	118					3.30712e-30	4.00055e-30	1	1	0
H1FNT	341567	broad.mit.edu	37	12	48723559	48723559	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr12:48723559G>A	ENST00000335017.1	+	1	797	c.485G>A	c.(484-486)cGc>cAc	p.R162H		NM_181788.1	NP_861453.1	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	162	Arg-rich.				chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	13						CAGCCCCTTCGCAAGGCGGCC	0.716000													3	4					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50455076	50455076	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr7:50455076G>A	ENST00000331340.3	+	6	778	c.623G>A	c.(622-624)cGa>cAa	p.R208Q	IKZF1_ENST00000349824.4_Intron|IKZF1_ENST00000438033.1_Missense_Mutation_p.R121Q|IKZF1_ENST00000346667.4_Intron|IKZF1_ENST00000359197.5_Intron|IKZF1_ENST00000357364.4_Intron|IKZF1_ENST00000440768.2_Intron|IKZF1_ENST00000343574.5_Missense_Mutation_p.R121Q|IKZF1_ENST00000439701.1_Intron	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	208					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(131)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				TATTGTGGCCGAAGCTATAAA	0.473000			"""D,T"""	BCL6	"""ALL, DLBCL"""								14	44					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8185589	8185589	+	Silent	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr8:8185589G>A	ENST00000520004.1	-	5	2967	c.2703C>T	c.(2701-2703)ggC>ggT	p.G901G	SGK223_ENST00000330777.4_Silent_p.G901G			Q86YV5	SG223_HUMAN		901							ATP binding|non-membrane spanning protein tyrosine kinase activity										TCCCGCAGCCGCCTCTGTTGC	0.657000													15	222					0	0	1	0	0
OR14K1	343170	broad.mit.edu	37	1	247902032	247902032	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr1:247902032T>C	ENST00000283225.2	+	1	116	c.116T>C	c.(115-117)aTg>aCg	p.M39T	RP11-634B7.4_ENST00000449298.1_RNA					olfactory receptor, family 14, subfamily K, member 1											NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|lung(18)|ovary(1)|urinary_tract(1)	27						GCTGTGCTGATGAATTTAGTC	0.448000													14	72					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143632509	143632509	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr7:143632509T>C	ENST00000408955.2	+	1	251	c.184T>C	c.(184-186)Ttt>Ctt	p.F62L		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F62L(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					CATGTATTTCTTTCTCACCAA	0.502000													24	455					0	0	1	0	0
FBXL13	222235	broad.mit.edu	37	7	102604004	102604004	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr7:102604004G>A	ENST00000393772.2	-	8	1126	c.700C>T	c.(700-702)Cga>Tga	p.R234*	FBXL13_ENST00000456695.1_Nonsense_Mutation_p.R234*|FBXL13_ENST00000471074.1_5'UTR|FBXL13_ENST00000379308.3_Nonsense_Mutation_p.R234*|FBXL13_ENST00000436908.1_Nonsense_Mutation_p.R234*|FBXL13_ENST00000379306.3_Nonsense_Mutation_p.R234*|FBXL13_ENST00000379305.3_Nonsense_Mutation_p.R234*|FBXL13_ENST00000313221.4_Nonsense_Mutation_p.R234*|FBXL13_ENST00000455112.2_Nonsense_Mutation_p.R234*			Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13	234										NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|skin(3)|stomach(1)	27						GTTTTGGGTCGGAGAAGACAA	0.338000													41	154					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76735813	76735813	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr10:76735813G>A	ENST00000287239.4	+	8	2207	c.1718G>A	c.(1717-1719)cGt>cAt	p.R573H	KAT6B_ENST00000372725.1_Intron|KAT6B_ENST00000372724.1_Intron|KAT6B_ENST00000372711.1_Intron|KAT6B_ENST00000372714.1_Intron	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	573	Negatively regulates HAT activity.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										CGTATGCGTCGTAAAACTGAA	0.453000													6	141					0	0	1	0	0
TOP2A	7153	broad.mit.edu	37	17	38564814	38564814	+	Missense_Mutation	SNP	G	G	T			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr17:38564814G>T	ENST00000423485.1	-	11	1430	c.1272C>A	c.(1270-1272)aaC>aaA	p.N424K		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	424					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	AACACTTCTTGTTTAACTGGA	0.363000													4	83					0.00909568	0.00974537	1	1	0
OR5K1	26339	broad.mit.edu	37	3	98188566	98188566	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr3:98188566T>C	ENST00000332650.5	+	1	243	c.146T>C	c.(145-147)aTa>aCa	p.I49T		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GTGGCACTGATATTTACACAC	0.458000													21	295					0	0	1	0	0
CCR8	1237	broad.mit.edu	37	3	39373836	39373836	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr3:39373836T>C	ENST00000326306.4	+	2	152	c.14T>C	c.(13-15)cTt>cCt	p.L5P	CCR8_ENST00000545843.1_5'UTR|CCR8_ENST00000414803.1_Missense_Mutation_p.L5P	NM_005201.3	NP_005192.1	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	5					cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			NS(3)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		GATTATACACTTGACCTCAGT	0.413000													43	58					0	0	1	0	0
RP11-275O4.3	0	broad.mit.edu	37	1	227698346	227698346	+	RNA	DEL	C	C	-			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr1:227698346delC	ENST00000422837.1	-	0	569																											GAGGAGGAGGCAGGGTGAGTC	0.592													2	4	---	---	---	---					
LAMC3	10319	broad.mit.edu	37	9	133884973	133884973	+	Splice_Site	DEL	A	A	-	rs35774154		TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr9:133884973delA	ENST00000361069.4	+	1	505	c.372delA	c.(370-372)cta>ct	p.L124fs	LAMC3_ENST00000480883.1_3'UTR	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	124	Laminin N-terminal.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CCCTCCGCCTAGGTAAGCGCG	0.687													2	4	---	---	---	---					
TUBBP5	643224	broad.mit.edu	37	9	141069453	141069453	+	RNA	DEL	C	C	-			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr9:141069453delC	ENST00000503395.1	+	0	1023																											GTCTGCTCCTCCTTCTCGCGC	0.662													2	4	---	---	---	---					
ZMIZ1	57178	broad.mit.edu	37	10	81052006	81052026	+	In_Frame_Del	DEL	GCAGCAGCGGCAGTGGCAGCA	GCAGCAGCGGCAGTGGCAGCA	-			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr10:81052006_81052026delGCAGCAGCGGCAGTGGCAGCA	ENST00000334512.5	+	11	1422_1442	c.850_870delGCAGCAGCGGCAGTGGCAGCA	c.(850-870)gcagcagcggcagtggcagcadel	p.AAAAVAA284del	ZMIZ1_ENST00000478357.1_3'UTR	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	284	Ala-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			ggcagccgctgcagcagcggcagtggcagcagcagcagcCA	0.652													37	100	---	---	---	---					
NOLC1	9221	broad.mit.edu	37	10	103919000	103919002	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr10:103919000_103919002delAGC	ENST00000405356.1	+	6	893_895	c.658_660delAGC	c.(658-660)agcdel	p.S227del	NOLC1_ENST00000488254.2_In_Frame_Del_p.S228del|NOLC1_ENST00000605788.1_In_Frame_Del_p.S227del|NOLC1_ENST00000603742.1_5'UTR	NM_001284388.1	NP_001271317.1	Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	227	11 X 12 AA approximate repeats of an acidic serine cluster.|Interacts with RPA194.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	31		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		tagcagcagtagcagcagcagca	0.517													10	241	---	---	---	---					
UNKL	64718	broad.mit.edu	37	16	1417745	1417745	+	Frame_Shift_Del	DEL	C	C	-			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr16:1417745delC	ENST00000389221.4	-	13	1690	c.1691delG	c.(1690-1692)ggafs	p.G564fs	UNKL_ENST00000391893.2_Frame_Shift_Del_p.G63fs|UNKL_ENST00000248104.7_Frame_Shift_Del_p.G63fs|UNKL_ENST00000402641.2_Frame_Shift_Del_p.G66fs|UNKL_ENST00000403703.1_Frame_Shift_Del_p.G66fs|UNKL_ENST00000397464.1_Frame_Shift_Del_p.G66fs|UNKL_ENST00000508903.2_Frame_Shift_Del_p.G567fs	NM_001193388.1	NP_001180317	Q9H9P5	UNKL_HUMAN	unkempt family zinc finger-like	564						cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|large_intestine(1)|lung(1)	4		Hepatocellular(780;0.0893)				CAGCTCAGCTCCGTTTGGACT	0.657													2	4	---	---	---	---					
UNK	85451	broad.mit.edu	37	17	73780866	73780866	+	Frame_Shift_Del	DEL	T	T	-			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr17:73780866delT	ENST00000293218.3	+	2	133	c.133delT	c.(133-135)ttcfs	p.F45fs	UNK_ENST00000589666.1_5'UTR|H3F3B_ENST00000586607.1_Intron			Q9C0B0	UNK_HUMAN	unkempt family zinc finger	0							nucleic acid binding|zinc ion binding			cervix(3)|endometrium(8)|kidney(2)|large_intestine(5)|lung(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	25			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGTCTTCACGTTCTCGTGGCG	0.617													8	45	---	---	---	---					
NLRP12	91662	broad.mit.edu	37	19	54314138	54314148	+	Frame_Shift_Del	DEL	CACTCTGGTTC	CACTCTGGTTC	-			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr19:54314138_54314148delCACTCTGGTTC	ENST00000324134.6	-	3	933_943	c.765_775delGAACCAGAGTG	c.(763-777)atgaaccagagtgccfs	p.MNQSA255fs	NLRP12_ENST00000535162.1_Frame_Shift_Del_p.MNQSA255fs|NLRP12_ENST00000391773.1_Frame_Shift_Del_p.MNQSA255fs|NLRP12_ENST00000391775.3_Frame_Shift_Del_p.MNQSA255fs|NLRP12_ENST00000345770.5_Frame_Shift_Del_p.MNQSA255fs|NLRP12_ENST00000391772.1_Frame_Shift_Del_p.MNQSA255fs|NLRP12_ENST00000351894.4_Frame_Shift_Del_p.MNQSA255fs|NLRP12_ENST00000354278.3_Frame_Shift_Del_p.MNQSA255fs	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	255	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CATTCCGTGGCACTCTGGTTCATCTCCCTGC	0.564													14	6	---	---	---	---					
UCKL1	54963	broad.mit.edu	37	20	62585381	62585381	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chr20:62585381delG	ENST00000595604.1	+	1	375	c.375delG	c.(373-375)ctgfs	p.L125fs	UCKL1_ENST00000358711.3_Intron|UCKL1_ENST00000354216.6_Intron|UCKL1_ENST00000369892.3_Intron																							AAATGAGGCTGGGGGGAGGAG	0.597													2	4	---	---	---	---					
LRCH2	57631	broad.mit.edu	37	X	114361427	114361427	+	Frame_Shift_Del	DEL	T	T	-			TCGA-TQ-A7RH-01A-12D-A34A-08	TCGA-TQ-A7RH-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92353c63-d5c2-4230-a396-f59612726e28	ec2bcc74-83ae-40d9-84f1-4655f7dcb336	g.chrX:114361427delT	ENST00000317135.8	-	16	1800	c.1770delA	c.(1768-1770)acafs	p.T590fs	LRCH2_ENST00000538422.1_Intron	NM_020871.3	NP_065922.3	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 2	590										breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	19						CTGGAGATTGTGTTGACATAT	0.284													2	4	---	---	---	---					
