Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SH3TC1	54436	broad.mit.edu	37	4	8218826	8218826	+	Silent	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr4:8218826G>A	ENST00000539824.1	+	7	917	c.543G>A	c.(541-543)ccG>ccA	p.P181P	SH3TC1_ENST00000245105.3_Silent_p.P257P			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	257							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						CTTCACCGCCGAGCCCCAGCG	0.672000													7	27					0	0	1	0	0
TMUB1	83590	broad.mit.edu	37	7	150779522	150779522	+	Silent	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr7:150779522C>T	ENST00000392818.3	-	2	486	c.129G>A	c.(127-129)ccG>ccA	p.P43P	TMUB1_ENST00000297533.4_Silent_p.P43P|TMUB1_ENST00000476627.1_Silent_p.P43P|TMUB1_ENST00000482202.1_Silent_p.P43P|TMUB1_ENST00000462940.1_Silent_p.P43P	NM_031434.3	NP_113622.1	Q9BVT8	TMUB1_HUMAN	transmembrane and ubiquitin-like domain containing 1	43						cytoplasm|integral to membrane|nucleus				endometrium(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGTCCCTGACGGCTGGGGCA	0.677000													20	82					0	0	1	0	0
HLA-DRB6	3128	broad.mit.edu	37	6	32522722	32522722	+	RNA	SNP	C	C	A	rs114905475	by1000genomes	TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr6:32522722C>A	ENST00000411500.1	-	0	484					NR_001298.1																						TGGGTCTTTGCAGGATACACA	0.488000													4	10					0.014758	0.0149719	1	1	0
TOP2B	7155	broad.mit.edu	37	3	25670393	25670393	+	Silent	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr3:25670393G>A	ENST00000435706.2	-	15	2037	c.1836C>T	c.(1834-1836)gaC>gaT	p.D612D	TOP2B_ENST00000264331.4_Silent_p.D617D			Q02880	TOP2B_HUMAN	topoisomerase (DNA) II beta 180kDa	617					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|skin(2)|stomach(1)	36						TTTTCCATTCGTCAAATTCAG	0.264000													4	60					0	0	1	0	0
PTPDC1	138639	broad.mit.edu	37	9	96859862	96859862	+	Silent	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr9:96859862C>T	ENST00000375360.3	+	7	1192	c.852C>T	c.(850-852)caC>caT	p.H284H	PTPDC1_ENST00000288976.3_Silent_p.H336H	NM_001253830.1|NM_177995.2	NP_001240759.1|NP_818931.1	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	284							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	32						TTCTGAAACACGTGCCAAAAA	0.478000													9	83					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29004260	29004260	+	Nonsense_Mutation	SNP	C	C	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr13:29004260C>A	ENST00000282397.4	-	8	1284	c.1033G>T	c.(1033-1035)Gaa>Taa	p.E345*	FLT1_ENST00000539099.1_Nonsense_Mutation_p.E345*|FLT1_ENST00000541932.1_Nonsense_Mutation_p.E345*	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	345	Ig-like C2-type 4.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GCTACGGTTTCAAGCACCTGC	0.408000													7	55					5.4927e-09	6.20144e-09	1	1	0
SOS1	6654	broad.mit.edu	37	2	39234309	39234309	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr2:39234309C>T	ENST00000426016.1	-	17	2622	c.2536G>A	c.(2536-2538)Gaa>Aaa	p.E846K	SOS1_ENST00000395038.2_Missense_Mutation_p.E846K|SOS1_ENST00000402219.2_Missense_Mutation_p.E846K			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	846	Ras-GEF.		E -> K (in NS4).		apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.E846K(1)		autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				ACTCTTTCTTCTAAATTTTCA	0.308000									Noonan syndrome				13	124					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55221710	55221710	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr7:55221710C>T	ENST00000275493.2	+	7	931	c.754C>T	c.(754-756)Cgc>Tgc	p.R252C	EGFR_ENST00000455089.1_Missense_Mutation_p.R207C|EGFR_ENST00000442591.1_Missense_Mutation_p.R252C|EGFR_ENST00000342916.3_Missense_Mutation_p.R252C|EGFR_ENST00000344576.2_Missense_Mutation_p.R252C|EGFR_ENST00000420316.2_Missense_Mutation_p.R252C|EGFR_ENST00000454757.2_Missense_Mutation_p.R199C	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	252					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.R252C(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	ATAGGTCTGCCGCAAATTCCG	0.582000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			5	60					0	0	1	0	0
CEL	1056	broad.mit.edu	37	9	135939834	135939834	+	Missense_Mutation	SNP	A	A	G			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr9:135939834A>G	ENST00000372080.4	+	2	135	c.119A>G	c.(118-120)aAt>aGt	p.N40S	CEL_ENST00000351304.7_Missense_Mutation_p.N37S	NM_001807.3	NP_001798.2	P19835	CEL_HUMAN	carboxyl ester lipase	37	Heparin-binding.				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|pancreas(2)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		GAAGGCGTCAATAAGAAGCTC	0.627000													6	57					0	0	1	0	0
CXCL8	3576	broad.mit.edu	37	4	74607730	74607730	+	Missense_Mutation	SNP	G	G	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr4:74607730G>T	ENST00000307407.3	+	3	418	c.265G>T	c.(265-267)Gtg>Ttg	p.V89L	IL8_ENST00000401931.1_Missense_Mutation_p.V89L	NM_000584.3	NP_000575.1	P10145	IL8_HUMAN	interleukin 8	89					angiogenesis|calcium-mediated signaling|cell cycle arrest|cellular response to lipopolysaccharide|embryonic digestive tract development|G-protein coupled receptor protein signaling pathway|immune response|induction of positive chemotaxis|inflammatory response|negative regulation of cell proliferation|neutrophil activation|neutrophil chemotaxis|positive regulation of neutrophil chemotaxis|regulation of cell adhesion|regulation of retroviral genome replication	extracellular space|intracellular	chemokine activity|interleukin-8 receptor binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(2)|urinary_tract(1)	6	Breast(15;0.00102)		all cancers(17;0.00169)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)	LUSC - Lung squamous cell carcinoma(721;0.008)	Ketoprofen(DB01009)|Salbutamol(DB01001)|Simvastatin(DB00641)|Zileuton(DB00744)	GCAGAGGGTTGTGGAGAAGTT	0.328000													4	55					1.23904e-05	1.33435e-05	1	1	0
SCAF11	9169	broad.mit.edu	37	12	46320546	46320546	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr12:46320546C>T	ENST00000465950.1	-	1	3202	c.1993G>A	c.(1993-1995)Gga>Aga	p.G665R	SCAF11_ENST00000549162.1_Missense_Mutation_p.G788R|SCAF11_ENST00000419565.2_Missense_Mutation_p.G980R|SCAF11_ENST00000369367.3_Missense_Mutation_p.G980R			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	980					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						CGATCATTTCCTCGTGGACAT	0.393000													18	155					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45949682	45949682	+	Splice_Site	SNP	A	A	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr21:45949682A>T	ENST00000323084.4	-	5	854	c.789T>A	c.(787-789)taT>taA	p.Y263*	TSPEAR_ENST00000397916.1_Splice_Site_p.Y195*	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	263					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						CCTACTAACCATAGGGATATT	0.642000													11	45					0	0	1	0	0
RECQL4	9401	broad.mit.edu	37	8	145742489	145742489	+	Missense_Mutation	SNP	C	C	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr8:145742489C>A	ENST00000428558.2	-	4	340	c.299G>T	c.(298-300)gGc>gTc	p.G100V	RECQL4_ENST00000532237.1_5'UTR	NM_004260.3	NP_004251.3	O94761	RECQ4_HUMAN	RecQ protein-like 4	100					DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CGGCACCGAGCCCTGGCGGCT	0.672000			"""N, F, S"""			"""osteosarcoma, skin basal and sqamous cell"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Rothmund-Thomson syndrome;RAPADILINO syndrome;Baller-Gerold syndrome				3	19					6.4e-05	6.68657e-05	1	1	0
MYO1G	64005	broad.mit.edu	37	7	45007262	45007262	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr7:45007262G>A	ENST00000258787.7	-	14	1860	c.1724C>T	c.(1723-1725)aCg>aTg	p.T575M		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	575	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						TGTGCCAGCCGTCAGGGGGCG	0.622000													11	61					0	0	1	0	0
RASSF9	9182	broad.mit.edu	37	12	86198645	86198645	+	Silent	SNP	T	T	C			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr12:86198645T>C	ENST00000361228.3	-	2	1511	c.1143A>G	c.(1141-1143)agA>agG	p.R381R		NM_005447.3	NP_005438.2	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	381					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ATTCCTTCGCTCTGTTTTCCT	0.418000													4	120					0	0	1	0	0
CCSER1	401145	broad.mit.edu	37	4	91549203	91549203	+	Silent	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr4:91549203C>T	ENST00000509176.1	+	6	2040	c.1752C>T	c.(1750-1752)gaC>gaT	p.D584D	CCSER1_ENST00000432775.2_Silent_p.D584D|CCSER1_ENST00000333691.8_Silent_p.D584D	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1									p.D586D(1)|p.D584D(1)									TAACAAAGGACGTTGATCAAG	0.418000													7	54					0	0	1	0	0
GNA14	9630	broad.mit.edu	37	9	80046294	80046294	+	Missense_Mutation	SNP	C	C	G			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr9:80046294C>G	ENST00000341700.6	-	4	1049	c.536G>C	c.(535-537)cGa>cCa	p.R179P	GNA14_ENST00000464095.1_5'UTR	NM_004297.3	NP_004288.1	O95837	GNA14_HUMAN	guanine nucleotide binding protein (G protein), alpha 14	179					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity	p.R179Q(1)		endometrium(3)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	24						GGTGGGCACTCGGACGCGAAG	0.493000													12	38					0	0	1	0	0
PCMTD1	115294	broad.mit.edu	37	8	52746176	52746176	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr8:52746176G>A	ENST00000360540.5	-	5	890	c.484C>T	c.(484-486)Cga>Tga	p.R162*	PCMTD1_ENST00000544451.1_Nonsense_Mutation_p.R86*|PCMTD1_ENST00000519559.1_5'UTR|PCMTD1_ENST00000522514.1_Nonsense_Mutation_p.R162*	NM_052937.2	NP_443169.2	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	162						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity			NS(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(17)|prostate(2)|skin(8)|soft_tissue(1)	37		Lung NSC(129;0.0795)|all_lung(136;0.144)				CAATAAATTCGATCATACTGA	0.363000													7	75					0	0	1	0	0
EIF4A2	1974	broad.mit.edu	37	3	186501416	186501416	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr3:186501416C>T	ENST00000323963.5	+	1	81	c.17C>T	c.(16-18)gCg>gTg	p.A6V	EIF4A2_ENST00000440191.2_Missense_Mutation_p.A6V|RP11-573D15.9_ENST00000577781.1_RNA|EIF4A2_ENST00000356531.5_5'UTR			Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	6					interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|urinary_tract(1)	28	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		GGTGGCTCCGCGGATTATAAC	0.567000			T	BCL6	NHL								4	113					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61602098	61602098	+	Missense_Mutation	SNP	G	G	C			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr18:61602098G>C	ENST00000238508.3	+	8	875	c.816G>C	c.(814-816)aaG>aaC	p.K272N	AC009802.1_ENST00000599868.1_Splice_Site_p.L13V	NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				CCTATGAGAAGCTGAATGAGT	0.443000													5	56					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56552353	56552353	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr19:56552353G>A	ENST00000390649.3	+	11	2852	c.2852G>A	c.(2851-2853)cGg>cAg	p.R951Q		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	951						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GTCAGCAACCGGAGCTTGACA	0.567000													7	74					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7579661	7579661	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr6:7579661G>A	ENST00000379802.3	+	23	3579	c.3238G>A	c.(3238-3240)Gag>Aag	p.E1080K	DSP_ENST00000418664.2_Missense_Mutation_p.E1080K	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1080	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGCGAGCCTGGAGGAGCTGAA	0.478000													4	63					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12908038	12908038	+	Silent	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr1:12908038C>T	ENST00000317869.6	-	2	330	c.105G>A	c.(103-105)gcG>gcA	p.A35A		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1									p.A35A(1)		NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TGGAAAAGATCGCCTCCACAT	0.473000													7	173					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9006762	9006762	+	Silent	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr19:9006762G>A	ENST00000397910.4	-	44	39689	c.39486C>T	c.(39484-39486)acC>acT	p.T13162T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13164					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAGAGGGCCGGTGGCTATAG	0.423000													7	102					0	0	1	0	0
MS4A4A	51338	broad.mit.edu	37	11	60064771	60064771	+	Silent	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr11:60064771C>T	ENST00000355131.3	+	4	469	c.246C>T	c.(244-246)atC>atT	p.I82I	MS4A4A_ENST00000337908.4_Silent_p.I101I|MS4A4A_ENST00000532114.1_Silent_p.I101I|MS4A4A_ENST00000395016.3_Silent_p.I82I	NM_024021.3	NP_076926.2	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member 4A	101						integral to membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(12)|prostate(1)|skin(4)	23						CCGTGTATATCGGGTACACAA	0.388000													5	91					0	0	1	0	0
ATP13A3	79572	broad.mit.edu	37	3	194154513	194154513	+	Missense_Mutation	SNP	C	C	T	rs138465420	by1000genomes	TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr3:194154513C>T	ENST00000439040.1	-	21	3024	c.2233G>A	c.(2233-2235)Gtc>Atc	p.V745I	ATP13A3_ENST00000256031.4_Missense_Mutation_p.V745I			Q9H7F0	AT133_HUMAN	ATPase type 13A3	745					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		GTGACCATGACGGTGCGAATG	0.348000													15	103					0	0	1	0	0
C9orf72	203228	broad.mit.edu	37	9	27565531	27565531	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr9:27565531G>A	ENST00000380003.3	-	3	565	c.502C>T	c.(502-504)Cag>Tag	p.Q168*	C9orf72_ENST00000488117.1_5'UTR|C9orf72_ENST00000379997.3_Nonsense_Mutation_p.Q168*	NM_001256054.1|NM_018325.3	NP_001242983.1|NP_060795.1	Q96LT7	CI072_HUMAN	chromosome 9 open reading frame 72	168										breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|pancreas(1)	23		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)		GCATATACCTGATCTTCCATT	0.353000													7	59					0	0	1	0	0
PHEX	5251	broad.mit.edu	37	X	22095783	22095783	+	Missense_Mutation	SNP	C	C	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chrX:22095783C>A	ENST00000379374.4	+	5	1191	c.626C>A	c.(625-627)tCc>tAc	p.S209Y	PHEX_ENST00000537599.1_Missense_Mutation_p.S209Y|PHEX_ENST00000535894.1_Missense_Mutation_p.S112Y	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	209					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						TTGTATGTGTCCCCTGATGAC	0.453000													14	93					4.3838e-07	4.79478e-07	1	1	0
KIAA1804	84451	broad.mit.edu	37	1	233518415	233518415	+	Silent	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr1:233518415C>T	ENST00000366624.3	+	10	3330	c.3069C>T	c.(3067-3069)agC>agT	p.S1023S	MLK4_ENST00000366622.1_Silent_p.S469S	NM_032435.2	NP_115811.2																					GCAAAACCAGCCGGCCATCTA	0.423000													4	51					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2621836	2621836	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr20:2621836C>T	ENST00000358864.1	+	20	2575	c.2560C>T	c.(2560-2562)Cct>Tct	p.P854S		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	854						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						GGCGCAGGGCCCTGGGACCTC	0.587000													8	92					0	0	1	0	0
HS3ST1	9957	broad.mit.edu	37	4	11401216	11401216	+	Silent	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr4:11401216C>T	ENST00000002596.5	-	2	1588	c.414G>A	c.(412-414)ccG>ccA	p.P138P		NM_005114.2	NP_005105.1	O14792	HS3S1_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	138						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|skin(3)	15						GCCGGATGGACGGGTTCATGC	0.592000													5	47					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68956801	68956801	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr8:68956801G>A	ENST00000288368.4	+	8	1196	c.919G>A	c.(919-921)Gtg>Atg	p.V307M	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	307	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						GGTGATGGAAGTGGAGAATGT	0.418000													8	78					0	0	1	0	0
LGALS13	29124	broad.mit.edu	37	19	40095888	40095888	+	Nonsense_Mutation	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr19:40095888C>T	ENST00000221797.4	+	3	208	c.163C>T	c.(163-165)Cga>Tga	p.R55*		NM_013268.2	NP_037400.1	Q9UHV8	PP13_HUMAN	lectin, galactoside-binding, soluble, 13	55	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			lung(5)|ovary(1)|urinary_tract(1)	7	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			CTTCCGTTTCCGAGTGCACTT	0.498000													4	34					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29586111	29586111	+	Missense_Mutation	SNP	A	A	G			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr17:29586111A>G	ENST00000358273.4	+	33	4777	c.4394A>G	c.(4393-4395)aAt>aGt	p.N1465S	NF1_ENST00000356175.3_Missense_Mutation_p.N1444S	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1465					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(5)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CGGCCTTTCAATGATTTTGTG	0.333000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			10	63					0	0	1	0	0
CD81	975	broad.mit.edu	37	11	2416679	2416679	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr11:2416679G>A	ENST00000263645.5	+	5	644	c.388G>A	c.(388-390)Gcc>Acc	p.A130T	CD81_ENST00000524805.1_3'UTR|CD81_ENST00000526072.1_Missense_Mutation_p.A59T|CD81_ENST00000492627.1_Missense_Mutation_p.A59T|CD81_ENST00000381036.3_Missense_Mutation_p.A168T|CD81_ENST00000481687.1_Missense_Mutation_p.A136T	NM_004356.3	NP_004347.1	P60033	CD81_HUMAN	CD81 molecule	130					activation of MAPK activity|cell proliferation|phosphatidylinositol biosynthetic process|positive regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization|regulation of immune response|virion attachment, binding of host cell surface receptor	integral to plasma membrane	protein binding			endometrium(1)|lung(3)|skin(1)	5		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000338)|LUSC - Lung squamous cell carcinoma(625;0.191)		CTATGACCAGGCCCTACAGCA	0.682000													7	36					0	0	1	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125298843	125298843	+	Silent	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chrX:125298843C>T	ENST00000538699.1	-	2	1145	c.1065G>A	c.(1063-1065)tcG>tcA	p.S355S	DCAF12L2_ENST00000360028.2_Silent_p.S355S	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	355										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						AGAAGCTCAGCGACCGCACGC	0.632000													6	36					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3240937	3240937	+	Missense_Mutation	SNP	A	A	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chrX:3240937A>T	ENST00000217939.6	-	5	2943	c.2789T>A	c.(2788-2790)gTc>gAc	p.V930D		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	930						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTTTTCATAGACTGTGTCTAA	0.507000													12	29					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100610076	100610076	+	Missense_Mutation	SNP	C	C	G	rs146817925	by1000genomes	TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr7:100610076C>G	ENST00000319509.7	+	10	2561	c.2561C>G	c.(2560-2562)gCc>gGc	p.A854G	RP11-395B7.2_ENST00000420080.1_RNA					mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						TTCCATGTGGCCTTGGAGAAC	0.567000													6	151					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7405004	7405004	+	Missense_Mutation	SNP	A	A	G			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr17:7405004A>G	ENST00000322644.6	+	14	2704	c.2305A>G	c.(2305-2307)Atg>Gtg	p.M769V		NM_000937.4	NP_000928	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	769					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding	p.M769V(1)		breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				CTTCAAGTCTATGGTCGTGTC	0.483000													5	61					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132207208	132207208	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr3:132207208G>A	ENST00000260818.6	+	30	3582	c.3334G>A	c.(3334-3336)Gat>Aat	p.D1112N		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1112							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						TATCATGCAAGATAACCCACA	0.373000													13	69					0	0	1	0	0
CRYGA	1418	broad.mit.edu	37	2	209027942	209027942	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr2:209027942G>A	ENST00000304502.4	-	2	257	c.238C>T	c.(238-240)Cgt>Tgt	p.R80C		NM_014617.3	NP_055432.2			crystallin, gamma A											endometrium(1)|kidney(3)|large_intestine(1)|lung(7)	12				Epithelial(149;0.067)|LUSC - Lung squamous cell carcinoma(261;0.0708)|Lung(261;0.135)		GGAATTATACGGCAGGATTGG	0.493000													9	49					0	0	1	0	0
PRDM7	11105	broad.mit.edu	37	16	90130121	90130121	+	Translation_Start_Site	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr16:90130121G>A	ENST00000407825.1	-	0	426				PRDM7_ENST00000449207.2_Missense_Mutation_p.T136M			Q9NQW5	PRDM7_HUMAN	PR domain containing 7							chromosome|nucleus	nucleic acid binding			lung(2)|ovary(2)|stomach(1)	5		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		TAAATTTGGCGTTCCTGACAA	0.413000													6	33					0	0	1	0	0
OR5T3	390154	broad.mit.edu	37	11	56020078	56020078	+	Missense_Mutation	SNP	G	G	T	rs143584658		TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr11:56020078G>T	ENST00000303059.3	+	1	403	c.403G>T	c.(403-405)Gtt>Ttt	p.V135F		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	135					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					GCTTCTTTTTGTTACTTTTGG	0.383000													13	183					4.3838e-07	4.79478e-07	1	1	0
RRAD	6236	broad.mit.edu	37	16	66956164	66956164	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr16:66956164C>T	ENST00000299759.6	-	5	992	c.742G>A	c.(742-744)Gtg>Atg	p.V248M	RRAD_ENST00000420652.1_Missense_Mutation_p.V248M			P55042	RAD_HUMAN	Ras-related associated with diabetes	248					small GTPase mediated signal transduction	plasma membrane	calmodulin binding|GTP binding|GTPase activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|urinary_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		ATCTGGCGCACGACACCTTCA	0.607000													8	41					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45949706	45949706	+	Silent	SNP	A	A	G			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr21:45949706A>G	ENST00000323084.4	-	5	830	c.765T>C	c.(763-765)gaT>gaC	p.D255D	TSPEAR_ENST00000397916.1_Silent_p.D187D	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	255					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						GCACCTCGTTATCTTCTGGCT	0.637000													9	43					0	0	1	0	0
COX6B1	1340	broad.mit.edu	37	19	36145573	36145573	+	Splice_Site	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr19:36145573G>A	ENST00000246554.3	+	3	399	c.207G>A	c.(205-207)tgG>tgA	p.W69*	COX6B1_ENST00000392201.1_Splice_Site_p.W69*|COX6B1_ENST00000592141.1_Splice_Site_p.W69*	NM_001863.4	NP_001854.1	P14854	CX6B1_HUMAN	cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)	69					respiratory electron transport chain	mitochondrial inner membrane|mitochondrial intermembrane space	cytochrome-c oxidase activity			lung(6)|prostate(1)|stomach(1)	8	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCACATCCTGGGTATGTGCCT	0.602000													4	53					0	0	1	0	0
GPRIN3	285513	broad.mit.edu	37	4	90171145	90171145	+	Silent	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr4:90171145G>A	ENST00000609438.1	-	2	635	c.117C>T	c.(115-117)ctC>ctT	p.L39L	GPRIN3_ENST00000333209.4_Silent_p.L39L	NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3				L -> V (in dbSNP:rs11734353).							breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		TCTTACACAGGAGAGCTGGTC	0.557000													4	69					0	0	1	0	0
C10orf10	11067	broad.mit.edu	37	10	45473358	45473358	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr10:45473358C>T	ENST00000298295.3	-	2	338	c.121G>A	c.(121-123)Gtg>Atg	p.V41M	RASSF4_ENST00000472561.1_Intron|RASSF4_ENST00000374417.2_Intron|RASSF4_ENST00000340258.5_Intron|RASSF4_ENST00000334940.6_Intron|C10orf10_ENST00000496638.1_Intron	NM_007021.3	NP_008952.1	Q9NTK1	DEPP_HUMAN	chromosome 10 open reading frame 10	41						mitochondrion				lung(1)	1						ATAGACCTCACGTAGTCATCC	0.662000													8	72					0	0	1	0	0
MRPL42	28977	broad.mit.edu	37	12	93881384	93881384	+	Missense_Mutation	SNP	C	C	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr12:93881384C>A	ENST00000549982.1	+	5	492	c.331C>A	c.(331-333)Caa>Aaa	p.Q111K	MRPL42_ENST00000547098.1_Missense_Mutation_p.Q111K|MRPL42_ENST00000393128.4_Missense_Mutation_p.Q111K|MRPL42_ENST00000548545.1_Missense_Mutation_p.Q111K|MRPL42_ENST00000361630.2_Missense_Mutation_p.Q111K|MRPL42_ENST00000552217.1_Missense_Mutation_p.Q111K	NM_014050.3|NM_172177.3	NP_054769.1|NP_751917.1	Q9Y6G3	RM42_HUMAN	mitochondrial ribosomal protein L42	111					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)	7						TATGATAGAACAACTTAGCAA	0.378000													8	140					0.307466	0.307466	1	1	0
CACNA2D3	55799	broad.mit.edu	37	3	54615867	54615867	+	Missense_Mutation	SNP	A	A	G			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr3:54615867A>G	ENST00000474759.1	+	9	974	c.926A>G	c.(925-927)aAt>aGt	p.N309S	CACNA2D3_ENST00000490478.1_Missense_Mutation_p.N215S|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.N309S|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.N309S	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	309	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CCTTGCCTGAATGGAACTTTG	0.448000													3	38					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113534718	113534718	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr12:113534718G>A	ENST00000257600.3	+	9	2340	c.1837G>A	c.(1837-1839)Gta>Ata	p.V613I	DTX1_ENST00000547974.1_3'UTR	NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	613					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						AGCCCAGGGCGTATCCGAGGC	0.632000													3	17					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522772	95522772	+	RNA	SNP	T	T	C			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr2:95522772T>C	ENST00000432432.2	-	0	255					NR_040113.1													p.E49G(1)									GCGCTCCACCTCCGCGGCGTC	0.682000													4	63					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140712371	140712371	+	Missense_Mutation	SNP	T	T	G			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr5:140712371T>G	ENST00000517417.1	+	1	2120	c.2120T>G	c.(2119-2121)tTc>tGc	p.F707C	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.F707C	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCCTGGCCTTCGTCATCGTG	0.662000													5	151					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237729966	237729966	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr1:237729966T>C	ENST00000366574.2	+	28	3631	c.3314T>C	c.(3313-3315)tTt>tCt	p.F1105S	RYR2_ENST00000360064.6_Missense_Mutation_p.F1103S|RYR2_ENST00000542537.1_Missense_Mutation_p.F1089S	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1105	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TATTTTGAATTTGAGACGGTC	0.557000													22	151					0	0	1	0	0
B4GALT4	8702	broad.mit.edu	37	3	118935161	118935161	+	Silent	SNP	C	C	T			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr3:118935161C>T	ENST00000467604.1	-	7	1219	c.828G>A	c.(826-828)cgG>cgA	p.R276R	B4GALT4_ENST00000460321.1_5'UTR|B4GALT4_ENST00000483209.1_Silent_p.R276R|B4GALT4_ENST00000359213.3_Silent_p.R276R|B4GALT4_ENST00000471675.1_Intron|B4GALT4_ENST00000393765.2_Silent_p.R276R			O60513	B4GT4_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4	276					membrane lipid metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding|N-acetyllactosamine synthase activity			breast(2)|endometrium(1)|large_intestine(1)|lung(6)|skin(2)|stomach(2)	14				GBM - Glioblastoma multiforme(114;0.222)	N-Acetyl-D-glucosamine(DB00141)	CAGGCAGGGGCCGGGAAATTT	0.418000													10	73					0	0	1	0	0
CAMK2B	816	broad.mit.edu	37	7	44323782	44323782	+	Silent	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr7:44323782G>A	ENST00000395749.2	-	2	184	c.108C>T	c.(106-108)acC>acT	p.T36T	CAMK2B_ENST00000395747.2_Silent_p.T36T|CAMK2B_ENST00000353625.4_Silent_p.T36T|CAMK2B_ENST00000440254.2_Silent_p.T36T|CAMK2B_ENST00000258682.6_Silent_p.T36T|CAMK2B_ENST00000358707.3_Silent_p.T36T|CAMK2B_ENST00000347193.4_Silent_p.T36T|CAMK2B_ENST00000502837.2_5'UTR|CAMK2B_ENST00000457475.1_Silent_p.T36T|CAMK2B_ENST00000346990.4_Silent_p.T36T|CAMK2B_ENST00000350811.3_Silent_p.T36T	NM_001220.4	NP_001211.3	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II beta	36	Protein kinase.				interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)	18						ACTCATGGCCGGTGCAGAGCT	0.587000													3	30					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74659800	74659800	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr15:74659800G>A	ENST00000268053.6	-	1	281	c.127C>T	c.(127-129)Cgc>Tgc	p.R43C	CYP11A1_ENST00000467407.1_5'UTR|CYP11A1_ENST00000541301.1_Missense_Mutation_p.R43C	NM_000781.2	NP_000772.2	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	43					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	CGAGGACTGCGGGTGGAGATG	0.617000													7	44					0	0	1	0	0
PTEN	5728	broad.mit.edu	37	10	89717741	89717741	+	Nonsense_Mutation	SNP	G	G	T	rs121909228		TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr10:89717741G>T	ENST00000371953.3	+	7	2123	c.766G>T	c.(766-768)Gag>Tag	p.E256*	PTEN_ENST00000472832.1_3'UTR	NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	256	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.R55fs*1(5)|p.N212fs*1(2)|p.Y27fs*1(2)|p.E256K(2)|p.G165_*404del(1)|p.?(1)|p.D252_K263>AKE(1)|p.K254fs*39(1)|p.E256*(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TATCAAAGTAGAGTTCTTCCA	0.373000		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			17	71					5.03518e-11	5.77808e-11	1	1	0
TMEM225	338661	broad.mit.edu	37	11	123753867	123753867	+	Missense_Mutation	SNP	C	C	T	rs114749572	byFrequency	TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr11:123753867C>T	ENST00000375026.2	-	4	872	c.656G>A	c.(655-657)cGt>cAt	p.R219H		NM_001013743.1	NP_001013765.1	Q6GV28	TM225_HUMAN	transmembrane protein 225	219						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	28						GGTTACGTGACGTGTTTGGAC	0.418000													7	84					0	0	1	0	0
C6orf25	80739	broad.mit.edu	37	6	31691585	31691585	+	Silent	SNP	C	C	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr6:31691585C>A	ENST00000375809.3	+	2	242	c.231C>A	c.(229-231)ctC>ctA	p.L77L	C6orf25_ENST00000375810.4_Silent_p.L77L|C6orf25_ENST00000375805.2_Silent_p.L77L|C6orf25_ENST00000480039.1_Silent_p.L77L	NM_025260.3|NM_138272.2|NM_138277.2	NP_079536.2|NP_612116.1|NP_612121.1	O95866	G6B_HUMAN	chromosome 6 open reading frame 25	77						endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	9						TGCCTCCCCTCCAGCCTTTCG	0.687000													6	83					3.59834e-05	3.81642e-05	1	1	0
MISP	126353	broad.mit.edu	37	19	757280	757280	+	Missense_Mutation	SNP	C	C	T	rs149547647		TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr19:757280C>T	ENST00000215582.6	+	2	437	c.334C>T	c.(334-336)Cgc>Tgc	p.R112C		NM_173481.2	NP_775752.1			mitotic spindle positioning																		ATGGGCACTCCGCCCAGAGGA	0.677000													5	31					0	0	1	0	0
ZNF681	148213	broad.mit.edu	37	19	23938242	23938242	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr19:23938242T>C	ENST00000402377.3	-	2	256	c.115A>G	c.(115-117)Aac>Gac	p.N39D	ZNF681_ENST00000395385.3_Intron	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				AAGACCAGGTTTCTGTAGTTC	0.348000													4	241					0	0	1	0	0
TRIM24	8805	broad.mit.edu	37	7	138223421	138223421	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr7:138223421G>A	ENST00000343526.4	+	7	1231	c.1016G>A	c.(1015-1017)cGc>cAc	p.R339H	TRIM24_ENST00000415680.2_Missense_Mutation_p.R339H|TRIM24_ENST00000497516.1_3'UTR			O15164	TIF1A_HUMAN	tripartite motif containing 24	339					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(5)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	40						AAGGACCATCGCATGAAACTT	0.388000													4	116					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5242305	5242305	+	Splice_Site	SNP	G	G	A			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr5:5242305G>A	ENST00000274181.7	+	17	2800		c.e17+1			NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						TGCGGAGGGGGTAGGTGCCTT	0.627000													5	33					0	0	1	0	0
COL9A2	1298	broad.mit.edu	37	1	40781308	40781308	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr1:40781308delG	ENST00000372748.3	-	2	200	c.104delC	c.(103-105)ccgfs	p.P35fs		NM_001852.3	NP_001843.1	Q14055	CO9A2_HUMAN	collagen, type IX, alpha 2	35	Triple-helical region 4 (COL4).				axon guidance|skeletal system development	collagen type IX				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(4)|stomach(2)|urinary_tract(2)	22	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			CGGGGGACCCGGGGGGCCCCG	0.682													2	4	---	---	---	---					
SETMAR	6419	broad.mit.edu	37	3	4355487	4355488	+	Frame_Shift_Ins	INS	-	-	G			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr3:4355487_4355488insG	ENST00000430981.1	+	2	1072_1073	c.1062_1063insG	c.(1063-1065)ggafs	p.G355fs	SUMF1_ENST00000534863.1_Intron|SETMAR_ENST00000358065.4_Intron|SETMAR_ENST00000425863.1_Intron	NM_001276325.1	NP_001263254.1	Q53H47	SETMR_HUMAN	SET domain and mariner transposase fusion gene	0	Mariner transposase Hsmar1.				DNA integration|DNA repair|transposition, DNA-mediated	chromosome|nucleus	DNA binding|endonuclease activity|histone-lysine N-methyltransferase activity|transposase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)	9		Melanoma(143;0.0657)		Epithelial(13;0.0025)|OV - Ovarian serous cystadenocarcinoma(96;0.011)|all cancers(10;0.0114)		CTCCCTATAGTGGAAGACAGTG	0.505								Chromatin Structure					7	37	---	---	---	---					
COQ3	51805	broad.mit.edu	37	6	99817677	99817680	+	Frame_Shift_Del	DEL	TGTT	TGTT	-	rs112847497		TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr6:99817677_99817680delTGTT	ENST00000254759.3	-	7	930_933	c.906_909delAACA	c.(904-909)caaacafs	p.QT302fs	COQ3_ENST00000369240.1_Frame_Shift_Del_p.QT74fs|COQ3_ENST00000369242.1_Frame_Shift_Del_p.QT74fs	NM_017421.3	NP_059117.3	Q9NZJ6	COQ3_HUMAN	coenzyme Q3 methyltransferase	302					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			cervix(1)|lung(5)|upper_aerodigestive_tract(2)	8		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		TTCCTACCACTGTTTGAACTGACA	0.368													9	198	---	---	---	---					
RP11-467H10.2	0	broad.mit.edu	37	7	76682746	76682747	+	RNA	INS	-	-	T	rs139676054	by1000genomes	TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr7:76682746_76682747insT	ENST00000459742.1	+	0	58																											GTggccgagagtggtggcttat	0.594													3	4	---	---	---	---					
LOC643542	643542	broad.mit.edu	37	18	65270178	65270178	+	RNA	DEL	C	C	-			TCGA-TQ-A7RP-01A-21D-A34A-08	TCGA-TQ-A7RP-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e657c6c-2788-4c2f-b9e9-767d234ee760	6fa8561b-e4ad-4ffa-b7b2-14e4cf3dd1ab	g.chr18:65270178delC	ENST00000583687.1	+	0	204					NR_033921.1																						TCTATTTCAGCAGAAGCCAGG	0.363													2	4	---	---	---	---					
