Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SEMA3E	9723	broad.mit.edu	37	7	83119432	83119432	+	Missense_Mutation	SNP	C	C	G			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr7:83119432C>G	ENST00000307792.3	-	2	741	c.274G>C	c.(274-276)Gag>Cag	p.E92Q	SEMA3E_ENST00000427262.1_Missense_Mutation_p.E32Q	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	92	Sema.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				TTCTATACCTCTTTATAGCCG	0.388000													17	36					0	0	1	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659593	24659593	+	RNA	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr22:24659593C>T	ENST00000414583.2	+	0	3118					NR_003714.1																						TCACTGACATCGAAGGCTGCC	0.632000													4	31					0	0	1	0	0
TUBA3D	113457	broad.mit.edu	37	2	132238154	132238154	+	Silent	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr2:132238154C>T	ENST00000321253.6	+	4	995	c.888C>T	c.(886-888)ttC>ttT	p.F296F		NM_080386.3	NP_525125.2	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	296					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		ATGCCTGCTTCGAGCCAGCCA	0.597000													61	220					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33463111	33463111	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr9:33463111G>A	ENST00000455041.2	-	24	3114	c.3055C>T	c.(3055-3057)Ctt>Ttt	p.L1019F	NOL6_ENST00000464829.1_Intron|NOL6_ENST00000379471.2_Intron			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	1071					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		TAGAAGAAAAGGGCCAGATCC	0.552000													9	20					0	0	1	0	0
DAAM1	23002	broad.mit.edu	37	14	59782054	59782054	+	Silent	SNP	C	C	G			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr14:59782054C>G	ENST00000395125.1	+	3	353	c.330C>G	c.(328-330)ctC>ctG	p.L110L	DAAM1_ENST00000351081.1_Silent_p.L110L|DAAM1_ENST00000360909.3_Silent_p.L110L	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	110	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding	p.L110L(1)		breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		TTGATCAGCTCAATTCCATGG	0.383000													11	90					0	0	1	0	0
GPR150	285601	broad.mit.edu	37	5	94956331	94956331	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr5:94956331G>A	ENST00000380007.2	+	1	550	c.352G>A	c.(352-354)Ggg>Agg	p.G118R		NM_199243.1	NP_954713.1	Q8NGU9	GP150_HUMAN	G protein-coupled receptor 150	118						integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(2)	2		all_cancers(142;0.000462)|all_epithelial(76;2.44e-06)|all_lung(232;0.0318)|Lung NSC(167;0.041)|Ovarian(225;0.051)		all cancers(79;1.82e-16)		CGCGGCCACGGGGGACCTGGC	0.766000													2	2					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50962009	50962009	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr19:50962009C>T	ENST00000357701.5	+	21	2555	c.2504C>T	c.(2503-2505)gCg>gTg	p.A835V		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	835					cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		AGGGAGATTGCGGGTGCGTGG	0.672000													3	17					0	0	1	0	0
NEK11	79858	broad.mit.edu	37	3	131068482	131068482	+	Missense_Mutation	SNP	C	C	T	rs147225516		TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:131068482C>T	ENST00000510688.1	+	16	1927	c.1703C>T	c.(1702-1704)gCg>gTg	p.A568V	NEK11_ENST00000383366.4_Silent_p.S600S|NEK11_ENST00000412440.2_Silent_p.S416S|NEK11_ENST00000508196.1_Silent_p.S600S|NEK11_ENST00000510769.1_Silent_p.S495S|RP11-933H2.4_ENST00000513905.1_RNA|NEK11_ENST00000429253.2_Silent_p.S600S|RP11-933H2.4_ENST00000502521.1_RNA	NM_001146003.1	NP_001139475.1	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11	0					cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|stomach(1)|urinary_tract(2)	33						AGAATGCTAGCGAAGCAGAGA	0.458000													22	47					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49161202	49161202	+	Silent	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:49161202G>A	ENST00000418109.1	-	25	3920	c.3756C>T	c.(3754-3756)gcC>gcT	p.A1252A	LAMB2_ENST00000305544.4_Silent_p.A1252A	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	1252	Domain II.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CAGTGGAGGCGGCTGAGGTGT	0.622000													53	25					0	0	1	0	0
RAB27A	5873	broad.mit.edu	37	15	55497845	55497845	+	Missense_Mutation	SNP	T	T	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr15:55497845T>A	ENST00000396307.2	-	6	777	c.526A>T	c.(526-528)Atg>Ttg	p.M176L	RAB27A_ENST00000569493.1_Missense_Mutation_p.M176L|RAB27A_ENST00000564609.1_Missense_Mutation_p.M176L|RAB27A_ENST00000336787.1_Missense_Mutation_p.M176L	NM_004580.4	NP_004571.2	P51159	RB27A_HUMAN	RAB27A, member RAS oncogene family	176					small GTPase mediated signal transduction	dendrite|exocytic vesicle|late endosome|lysosome|melanosome	GTP binding|GTPase activity			endometrium(1)|large_intestine(2)|liver(1)|lung(3)|ovary(1)|skin(1)	9				all cancers(107;0.0273)|GBM - Glioblastoma multiforme(80;0.0993)		TCCAGAAGCATCTCAATTGCT	0.473000													27	44					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6241395	6241395	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr18:6241395G>T	ENST00000400104.3	-	8	714	c.514C>A	c.(514-516)Caa>Aaa	p.Q172K	L3MBTL4_ENST00000284898.6_Missense_Mutation_p.Q172K|L3MBTL4_ENST00000400105.2_Missense_Mutation_p.Q172K|L3MBTL4_ENST00000535782.1_5'UTR|L3MBTL4_ENST00000317931.7_Missense_Mutation_p.Q172K			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	172					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				GGAGCATTTTGCAATTTGCAG	0.308000													73	19					1.15773e-35	1.28289e-35	1	1	0
TG	7038	broad.mit.edu	37	8	134128882	134128882	+	Missense_Mutation	SNP	A	A	G			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr8:134128882A>G	ENST00000220616.4	+	45	7824	c.7784A>G	c.(7783-7785)gAc>gGc	p.D2595G	TG_ENST00000519543.1_Missense_Mutation_p.D728G|TG_ENST00000377869.1_Missense_Mutation_p.D2538G|TG_ENST00000542445.1_Missense_Mutation_p.D965G	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2595					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCTATAATCGACATGGCCAGT	0.537000													57	69					0	0	1	0	0
ZDHHC14	79683	broad.mit.edu	37	6	158068387	158068387	+	Missense_Mutation	SNP	C	C	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr6:158068387C>A	ENST00000359775.5	+	7	1841	c.952C>A	c.(952-954)Ccc>Acc	p.P318T	ZDHHC14_ENST00000341375.8_3'UTR|ZDHHC14_ENST00000414563.2_Missense_Mutation_p.P318T			Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14	318						integral to membrane	acyltransferase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	17		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		CCTGTGTGGGCCCATCTCACC	0.498000													24	80					2.21704e-12	2.30123e-12	1	1	0
C17orf97	400566	broad.mit.edu	37	17	263352	263352	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr17:263352G>A	ENST00000360127.6	+	2	734	c.718G>A	c.(718-720)Gag>Aag	p.E240K	AC108004.3_ENST00000466740.2_RNA|C17orf97_ENST00000571106.1_Intron	NM_001013672.4	NP_001013694.4	Q6ZQX7	CQ097_HUMAN	chromosome 17 open reading frame 97	270	20 X 10 AA approximative tandem repeat of A-L-K-G-F-H-P-D-P-E.			E -> D (in Ref. 3; AAH57385).				p.E240K(2)		breast(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)	14						CCCCGACCCCGAGGCCCTCAA	0.726000													3	29					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33638268	33638268	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr6:33638268G>A	ENST00000374316.5	+	20	3416	c.2356G>A	c.(2356-2358)Gtg>Atg	p.V786M	ITPR3_ENST00000605930.1_Missense_Mutation_p.V786M			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	786					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						GCACGTGCACGTGGACCGTGA	0.622000													50	101					0	0	1	0	0
IDE	3416	broad.mit.edu	37	10	94214273	94214273	+	Silent	SNP	G	G	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr10:94214273G>T	ENST00000265986.6	-	25	3044	c.2988C>A	c.(2986-2988)acC>acA	p.T996T	IDE_ENST00000496903.1_5'UTR|IDE_ENST00000371581.5_Silent_p.T441T	NM_004969.3	NP_004960.2	P14735	IDE_HUMAN	insulin-degrading enzyme	996					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|urinary_tract(2)	33					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCTTGAATTCGGTCATGTTCT	0.408000													35	46					3.62531e-18	3.91152e-18	1	1	0
EFCAB12	90288	broad.mit.edu	37	3	129123129	129123129	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:129123129C>T	ENST00000505956.1	-	7	1529	c.1367G>A	c.(1366-1368)cGg>cAg	p.R456Q	EFCAB12_ENST00000326085.3_Missense_Mutation_p.R456Q	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		GCCCTGGGACCGGAGCAGAGC	0.562000													55	59					0	0	1	0	0
DDX19A	55308	broad.mit.edu	37	16	70400656	70400656	+	Silent	SNP	T	T	C	rs142443034	byFrequency	TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr16:70400656T>C	ENST00000302243.7	+	9	1075	c.912T>C	c.(910-912)gaT>gaC	p.D304D	DDX19A_ENST00000443119.2_Silent_p.D214D|DDX19A_ENST00000417604.2_Silent_p.D273D	NM_018332.3	NP_060802.1			DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A											breast(1)|endometrium(1)|large_intestine(5)|lung(3)|urinary_tract(1)	11		Ovarian(137;0.221)				AGACCCTGGATACCATCAAGC	0.502000													25	101					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25475911	25475911	+	RNA	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr15:25475911G>A	ENST00000453082.2	+	0	1506					NR_003343.1																						CCTTCCTGGCGCCCTGGACTG	0.597000													32	41					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414902	14414902	+	RNA	SNP	G	G	A	rs2821609	by1000genomes	TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr21:14414902G>A	ENST00000507941.1	+	0	95																											CCAGCTTGACGTCCTTGATGG	0.443000													4	32					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23716446	23716446	+	Silent	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr16:23716446G>A	ENST00000256797.4	-	8	924	c.756C>T	c.(754-756)tgC>tgT	p.C252C	ERN2_ENST00000457008.2_Silent_p.C204C	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	204					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GGCCCATCCCGCAGGACGCCA	0.647000													18	42					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1056090	1056090	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr19:1056090C>T	ENST00000263094.6	+	32	4495	c.4264C>T	c.(4264-4266)Cga>Tga	p.R1422*	ABCA7_ENST00000433129.1_Nonsense_Mutation_p.R1422*|ABCA7_ENST00000435683.2_Nonsense_Mutation_p.R1284*	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	1422					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGGGGGGCCGAGACCCAGG	0.726000													30	38					0	0	1	0	0
ABL2	27	broad.mit.edu	37	1	179100469	179100469	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr1:179100469T>C	ENST00000502732.1	-	3	571	c.368A>G	c.(367-369)gAt>gGt	p.D123G	ABL2_ENST00000504405.1_Missense_Mutation_p.D87G|ABL2_ENST00000408940.3_Missense_Mutation_p.D87G|ABL2_ENST00000512653.1_Missense_Mutation_p.D108G|ABL2_ENST00000367623.4_Missense_Mutation_p.D102G|ABL2_ENST00000507173.1_Missense_Mutation_p.D102G|ABL2_ENST00000392043.3_Missense_Mutation_p.D102G|ABL2_ENST00000344730.3_Missense_Mutation_p.D108G|ABL2_ENST00000511413.1_Missense_Mutation_p.D123G	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	123	SH3.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GAGTGTGTTATCACCACTTGC	0.448000			T	ETV6	AML								4	73					0	0	1	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26156726	26156726	+	Silent	SNP	T	T	A	rs148044098		TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr6:26156726T>A	ENST00000304218.3	+	1	168	c.108T>A	c.(106-108)tcT>tcA	p.S36S		NM_005321.2	NP_005312.1	P10412	H14_HUMAN	histone cluster 1, H1e	36	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	26						GCAAAGCGTCTGGGCCCCCGG	0.662000													47	31					0	0	1	0	0
EHD2	30846	broad.mit.edu	37	19	48244389	48244389	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr19:48244389G>A	ENST00000263277.3	+	6	1583	c.1332G>A	c.(1330-1332)tgG>tgA	p.W444*	EHD2_ENST00000538399.1_Nonsense_Mutation_p.W308*|EHD2_ENST00000540884.1_3'UTR	NM_014601.3	NP_055416.2	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	444					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			endometrium(3)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	19		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		AGGCCGAGTGGGTGGTGACCA	0.647000													6	44					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72845967	72845967	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr17:72845967C>T	ENST00000293190.5	-	7	1743	c.1597G>A	c.(1597-1599)Gtg>Atg	p.V533M	GRIN2C_ENST00000347612.4_Missense_Mutation_p.V533M	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	533					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	GCCACCATCACACTGATGCCC	0.637000													8	103					0	0	1	0	0
C1orf65	164127	broad.mit.edu	37	1	223568629	223568629	+	Silent	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr1:223568629C>T	ENST00000366875.3	+	1	1915	c.1812C>T	c.(1810-1812)tcC>tcT	p.S604S		NM_152610.2	NP_689823.2	Q8N715	CA065_HUMAN	chromosome 1 open reading frame 65	604										breast(4)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|skin(3)	29				GBM - Glioblastoma multiforme(131;0.0704)		CCAACAGCTCCCTTGATCAGA	0.582000													19	34					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100491367	100491367	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr7:100491367C>T	ENST00000302913.4	-	2	625	c.487G>A	c.(487-489)Gtg>Atg	p.V163M	ACHE_ENST00000419336.2_Missense_Mutation_p.V163M|ACHE_ENST00000241069.5_Missense_Mutation_p.V163M|ACHE_ENST00000428317.1_Missense_Mutation_p.V163M|ACHE_ENST00000412389.1_Missense_Mutation_p.V163M|ACHE_ENST00000411582.1_Missense_Mutation_p.V163M	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	163					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	CCATCGTACACGTCCAAGGAG	0.637000													33	115					0	0	1	0	0
DYRK1A	1859	broad.mit.edu	37	21	38884668	38884668	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr21:38884668G>A	ENST00000339659.4	+	11	3569	c.2099G>A	c.(2098-2100)cGc>cAc	p.R700H	DYRK1A_ENST00000338785.3_3'UTR|DYRK1A_ENST00000455387.2_Missense_Mutation_p.R481H|DYRK1A_ENST00000398960.2_Missense_Mutation_p.R709H	NM_130436.2	NP_569120.1	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A						nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			breast(4)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						TCCAATCCCCGCCAAGAGACT	0.488000													50	41					0	0	1	0	0
TFEC	22797	broad.mit.edu	37	7	115614246	115614246	+	Missense_Mutation	SNP	G	G	C			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr7:115614246G>C	ENST00000265440.7	-	3	425	c.245C>G	c.(244-246)tCt>tGt	p.S82C	TFEC_ENST00000484212.1_Missense_Mutation_p.S172C|TFEC_ENST00000320239.7_Intron|TFEC_ENST00000393485.1_Intron	NM_012252.3	NP_036384.1	O14948	TFEC_HUMAN	transcription factor EC	82	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			TAGCAGAGGAGAGTCTGCTCC	0.333000													8	48					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72346559	72346559	+	Silent	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr17:72346559C>T	ENST00000389916.4	+	11	1371	c.1233C>T	c.(1231-1233)agC>agT	p.S411S		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	411					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						AGCTGCACAGCGGGCAGGGTG	0.672000													11	9					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147108875	147108875	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:147108875T>C	ENST00000383075.3	-	4	1359	c.847A>G	c.(847-849)Aag>Gag	p.K283E	ZIC4_ENST00000525172.2_Missense_Mutation_p.K333E|ZIC4_ENST00000473123.1_Missense_Mutation_p.K283E|ZIC4_ENST00000425731.3_Missense_Mutation_p.K321E|ZIC4_ENST00000472749.2_5'UTR|ZIC4_ENST00000491672.1_Missense_Mutation_p.K77E|ZIC4_ENST00000484399.1_Missense_Mutation_p.K283E	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	283						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						TTCATGTGCTTACGCAGCGAG	0.642000													33	30					0	0	1	0	0
PRDX6	9588	broad.mit.edu	37	1	173450467	173450467	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr1:173450467G>T	ENST00000340385.5	+	2	230	c.98G>T	c.(97-99)tGg>tTg	p.W33L	PRDX6_ENST00000470017.1_3'UTR	NM_004905.2	NP_004896.1	P30041	PRDX6_HUMAN	peroxiredoxin 6	33	Thioredoxin.				cell redox homeostasis|phospholipid catabolic process	cytoplasmic membrane-bounded vesicle|cytosol|lysosome	peroxiredoxin activity|phospholipase A2 activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	12						CCTTTCAGATGGGGCATTCTC	0.453000													5	80					4.096e-09	4.14657e-09	1	1	0
DEFB119	245932	broad.mit.edu	37	20	29966170	29966170	+	Missense_Mutation	SNP	C	C	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr20:29966170C>A	ENST00000339144.3	-	2	192	c.86G>T	c.(85-87)tGc>tTc	p.C29F	DEFB119_ENST00000492344.1_5'UTR|DEFB119_ENST00000376321.3_Intron			Q8N690	DB119_HUMAN	defensin, beta 119	0					defense response to bacterium	extracellular region				large_intestine(2)|lung(1)|prostate(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			agtatccaggcagcatcccac	0.488000													17	180					2.4624e-09	2.52396e-09	1	1	0
CSF2RA	1438	broad.mit.edu	37	X	1409282	1409282	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chrX:1409282G>T	ENST00000381524.3	+	7	712	c.526G>T	c.(526-528)Gtg>Ttg	p.V176L	CSF2RA_ENST00000355432.3_Missense_Mutation_p.V176L|CSF2RA_ENST00000494969.2_Intron|CSF2RA_ENST00000381500.1_Missense_Mutation_p.V176L|CSF2RA_ENST00000417535.2_Missense_Mutation_p.V176L|CSF2RA_ENST00000432318.2_Missense_Mutation_p.V176L|CSF2RA_ENST00000361536.3_Missense_Mutation_p.V176L|CSF2RA_ENST00000381529.3_Missense_Mutation_p.V176L|CSF2RA_ENST00000355805.2_Missense_Mutation_p.V176L|CSF2RA_ENST00000501036.2_Missense_Mutation_p.V43L|CSF2RA_ENST00000381509.3_Missense_Mutation_p.V176L			P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	176						extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(6)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	45		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	AGGAACCCATGTGGGATGTCA	0.433000													38	196					5.20837e-25	5.69448e-25	1	1	0
ZNF812	729648	broad.mit.edu	37	19	9801052	9801052	+	Missense_Mutation	SNP	C	C	T	rs115285977	by1000genomes	TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr19:9801052C>T	ENST00000457674.2	-	5	1645	c.1127G>A	c.(1126-1128)cGt>cAt	p.R376H	ZNF812_ENST00000536819.1_5'UTR	NM_001199814.1	NP_001186743.1	P0C7V5	ZN812_HUMAN	zinc finger protein 812	376					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATGTTTACTACGATAGGAAGA	0.388000													27	42					0	0	1	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659591	24659591	+	RNA	SNP	A	A	G			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr22:24659591A>G	ENST00000414583.2	+	0	3116					NR_003714.1																						ACTCACTGACATCGAAGGCTG	0.632000													4	32					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								37	27					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17250900	17250900	+	Missense_Mutation	SNP	G	G	A	rs140882535		TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr1:17250900G>A	ENST00000375541.5	+	3	346	c.277G>A	c.(277-279)Gtg>Atg	p.V93M	CROCC_ENST00000467938.1_Intron	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	93					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GCTGTCCCGCGTGGAGGACCT	0.657000													18	24					0	0	1	0	0
HAUS1	115106	broad.mit.edu	37	18	43685266	43685266	+	Missense_Mutation	SNP	T	T	G			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr18:43685266T>G	ENST00000282058.6	+	2	217	c.137T>G	c.(136-138)gTc>gGc	p.V46G	HAUS1_ENST00000585518.1_Missense_Mutation_p.V46G	NM_138443.3	NP_612452.1	Q96CS2	HAUS1_HUMAN	HAUS augmin-like complex, subunit 1	46					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	7						CGCAACAGGGTCCGGGACAGG	0.438000													24	2					0	0	1	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20370287	20370287	+	RNA	SNP	T	T	C			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr19:20370287T>C	ENST00000593655.1	-	0	199																											ATTGCCAATCTTTGAACTCAT	0.408000													5	12					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13600893	13600893	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr4:13600893C>T	ENST00000040738.5	-	10	7766	c.7631G>A	c.(7630-7632)gGg>gAg	p.G2544E		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	2544							DNA binding										AGCCACGGTCCCTTGAACAGG	0.493000											OREG0016115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	9					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21817119	21817119	+	Missense_Mutation	SNP	C	C	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr5:21817119C>A	ENST00000382254.1	-	9	2023	c.937G>T	c.(937-939)Ggg>Tgg	p.G313W	CDH12_ENST00000522262.1_Missense_Mutation_p.G273W|CDH12_ENST00000504376.2_Missense_Mutation_p.G313W|CDH12_ENST00000521384.1_5'UTR	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	313	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						AAATTTCCCCCATCTCCTGGA	0.383000										HNSCC(59;0.17)			62	98					3.00467e-41	3.37511e-41	1	1	0
CMAS	55907	broad.mit.edu	37	12	22199458	22199458	+	Missense_Mutation	SNP	G	G	C			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr12:22199458G>C	ENST00000229329.2	+	1	351	c.221G>C	c.(220-222)tGg>tCg	p.W74S		NM_018686.4	NP_061156.1	Q8NFW8	NEUA_HUMAN	cytidine monophosphate N-acetylneuraminic acid synthetase	74					lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24						CTCATTGGCTGGGTCCTGCGT	0.692000													9	11					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156846352	156846352	+	Missense_Mutation	SNP	A	A	G			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr1:156846352A>G	ENST00000368196.3	+	13	1895	c.1775A>G	c.(1774-1776)aAc>aGc	p.N592S	NTRK1_ENST00000358660.3_Missense_Mutation_p.N595S|NTRK1_ENST00000392302.2_Missense_Mutation_p.N562S|NTRK1_ENST00000524377.1_Missense_Mutation_p.N598S	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	598	Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GGGGACCTCAACCGCTTCCTC	0.642000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			7	16					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46660106	46660106	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr6:46660106T>C	ENST00000544460.1	+	1	4495	c.4241T>C	c.(4240-4242)tTg>tCg	p.L1414S	TDRD6_ENST00000316081.6_Missense_Mutation_p.L1414S	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1414					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			TTGCCGGGGTTGTGCATTCAT	0.408000													109	92					0	0	1	0	0
C20orf112	140688	broad.mit.edu	37	20	31035489	31035489	+	Silent	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr20:31035489C>T	ENST00000359676.5	-	8	1363	c.1221G>A	c.(1219-1221)gtG>gtA	p.V407V		NM_001256798.1|NM_080616.4	NP_001243727.1|NP_542183.2	Q96MY1	CT112_HUMAN	chromosome 20 open reading frame 112	407										endometrium(3)|kidney(2)|large_intestine(5)|lung(5)	15						TGAGCTGCCGCACGGCGCTGA	0.672000													28	30					0	0	1	0	0
FAM86DP	692099	broad.mit.edu	37	3	75476735	75476735	+	RNA	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:75476735C>T	ENST00000459803.1	-	0	621					NR_024241.1													p.E194E(3)									CTCGGAGCTGCTCGAGGACCC	0.602000													5	46					0	0	1	0	0
ANAPC2	29882	broad.mit.edu	37	9	140082874	140082874	+	Silent	SNP	C	C	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr9:140082874C>A	ENST00000323927.2	-	1	115	c.111G>T	c.(109-111)ctG>ctT	p.L37L		NM_013366.3	NP_037498.1	Q9UJX6	ANC2_HUMAN	anaphase promoting complex subunit 2	37					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		TCACCAGCCCCAGCGCAGCCG	0.706000													3	24					6.4e-05	6.4e-05	1	1	0
GRM2	2912	broad.mit.edu	37	3	51751835	51751835	+	Splice_Site	SNP	T	T	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:51751835T>A	ENST00000395052.3	+	5	2779		c.e5+2		GRM2_ENST00000442933.2_Splice_Site|GRM2_ENST00000475478.1_Splice_Site	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2						synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	TTGGCCAAGGTCAGTGTCCTA	0.622000													20	22					0	0	1	0	0
SYNRG	11276	broad.mit.edu	37	17	35902074	35902074	+	Splice_Site	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr17:35902074C>T	ENST00000339208.6	-	15	3342	c.3202G>A	c.(3202-3204)Gga>Aga	p.G1068R	SYNRG_ENST00000346661.4_Splice_Site_p.G1068R|SYNRG_ENST00000345615.4_Splice_Site_p.G990R|SYNRG_ENST00000585472.1_Splice_Site_p.G989R|SYNRG_ENST00000591288.1_Splice_Site_p.G862R|SYNRG_ENST00000502449.2_Splice_Site_p.G945R|SYNRG_ENST00000394378.2_Splice_Site_p.G990R	NM_001163544.1|NM_001163545.1|NM_007247.4	NP_001157016.1|NP_001157017.1|NP_009178.3	Q9UMZ2	SYNRG_HUMAN	synergin, gamma	1068					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AGCTACTCACCTTGAACAGAA	0.373000													49	57					0	0	1	0	0
CD300LF	146722	broad.mit.edu	37	17	72700686	72700686	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr17:72700686T>C	ENST00000469092.1	-	3	598	c.322A>G	c.(322-324)Act>Gct	p.T108A	RAB37_ENST00000402449.4_Intron|CD300LF_ENST00000361254.4_Missense_Mutation_p.T108A|CD300LF_ENST00000343125.4_Missense_Mutation_p.T108A|CD300LF_ENST00000581500.1_Missense_Mutation_p.T108A|RAB37_ENST00000340415.3_Intron|CD300LF_ENST00000464910.1_Missense_Mutation_p.T108A|CD300LF_ENST00000301573.9_Missense_Mutation_p.T105A|CD300LF_ENST00000583937.1_Missense_Mutation_p.T105A|CD300LF_ENST00000326165.6_Missense_Mutation_p.T105A			Q8TDQ1	CLM1_HUMAN	CD300 molecule-like family member f	105	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						CACCAGTAAGTGTCAGCATCA	0.478000													71	104					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14849266	14849266	+	Silent	SNP	G	G	C			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr12:14849266G>C	ENST00000261170.3	-	1	253	c.117C>G	c.(115-117)gtC>gtG	p.V39V	RP11-174G6.1_ENST00000501178.2_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	39					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						CCATCATCAGGACGCTGATTT	0.527000													13	37					0	0	1	0	0
UGT1A1	54658	broad.mit.edu	37	2	234526858	234526858	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr2:234526858G>A	ENST00000373450.4	+	1	568	c.505G>A	c.(505-507)Gcc>Acc	p.A169T		NM_019076.4	NP_061949.3	P22309	UD11_HUMAN							bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	TGTGGTCTTCGCCAGGGGAAT	0.468000													53	192					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48210912	48210912	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr16:48210912G>T	ENST00000394747.1	-	24	3810	c.3461C>A	c.(3460-3462)aCa>aAa	p.T1154K	ABCC11_ENST00000356608.2_Missense_Mutation_p.T1154K|ABCC11_ENST00000565329.1_5'UTR|ABCC11_ENST00000394748.1_Missense_Mutation_p.T1154K|ABCC11_ENST00000353782.5_Missense_Mutation_p.T1154K	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	1154	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CACGGTGGGTGTGTTGTCTCT	0.557000													20	15					1.56452e-12	1.64476e-12	1	1	0
KRT6C	286887	broad.mit.edu	37	12	52867083	52867083	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr12:52867083G>A	ENST00000252250.6	-	1	486	c.439C>T	c.(439-441)Ccc>Tcc	p.P147S		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	147	Head.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		AGGTTGAGGGGAGTCAGGAGA	0.617000													39	22					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79460508	79460508	+	Missense_Mutation	SNP	T	T	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr4:79460508T>A	ENST00000264895.6	+	73	11799	c.11359T>A	c.(11359-11361)Ttt>Att	p.F3787I		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3782					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TGAGGCTCACTTTGCCTCTGA	0.418000													13	77					0	0	1	0	0
GIMAP7	168537	broad.mit.edu	37	7	150217736	150217736	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr7:150217736C>T	ENST00000313543.4	+	2	831	c.674C>T	c.(673-675)aCt>aTt	p.T225I		NM_153236.3	NP_694968.1	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	225							GTP binding			breast(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	17			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AAAATCTACACTGACCAATTA	0.343000													22	36					0	0	1	0	0
DYNC1I2	1781	broad.mit.edu	37	2	172549335	172549335	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr2:172549335C>T	ENST00000534253.2	+	3	325	c.157C>T	c.(157-159)Ctt>Ttt	p.L53F	DYNC1I2_ENST00000409317.1_Missense_Mutation_p.L53F|DYNC1I2_ENST00000340296.4_Missense_Mutation_p.L53F|DYNC1I2_ENST00000409773.1_Missense_Mutation_p.L53F|DYNC1I2_ENST00000397119.3_Missense_Mutation_p.L53F|DYNC1I2_ENST00000508530.1_Missense_Mutation_p.L53F|DYNC1I2_ENST00000263811.4_Missense_Mutation_p.L53F|DYNC1I2_ENST00000358002.6_Missense_Mutation_p.L53F|DYNC1I2_ENST00000409453.1_Missense_Mutation_p.L53F|DYNC1I2_ENST00000409197.1_Missense_Mutation_p.L53F|DYNC1I2_ENST00000410079.3_Missense_Mutation_p.L53F			Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	53					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.198)			AGAATCAGATCTTGAAAAAAA	0.353000													7	16					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43897195	43897195	+	Splice_Site	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr1:43897195G>A	ENST00000562955.1	+	34	4917		c.e34+1		SZT2_ENST00000372442.1_Splice_Site	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)							peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CATGAATGAGGTGAGCCCCCC	0.498000													58	14					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51392325	51392325	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:51392325G>T	ENST00000266037.9	+	41	4143	c.4120G>T	c.(4120-4122)Gtg>Ttg	p.V1374L		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1374	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CAAAGAATACGTGTGCCGTGG	0.542000													39	131					8.69298e-16	9.25746e-16	1	1	0
C20orf112	140688	broad.mit.edu	37	20	31035488	31035488	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr20:31035488G>A	ENST00000359676.5	-	8	1364	c.1222C>T	c.(1222-1224)Cgg>Tgg	p.R408W		NM_001256798.1|NM_080616.4	NP_001243727.1|NP_542183.2	Q96MY1	CT112_HUMAN	chromosome 20 open reading frame 112	408										endometrium(3)|kidney(2)|large_intestine(5)|lung(5)	15						ATGAGCTGCCGCACGGCGCTG	0.667000													27	29					0	0	1	0	0
LYPD6B	130576	broad.mit.edu	37	2	150064872	150064872	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr2:150064872G>A	ENST00000409642.3	+	5	675	c.274G>A	c.(274-276)Gca>Aca	p.A92T	LYPD6B_ENST00000409876.1_Missense_Mutation_p.A68T|LYPD6B_ENST00000280115.7_Missense_Mutation_p.A92T|LYPD6B_ENST00000498249.1_3'UTR|LYPD6B_ENST00000409029.1_Missense_Mutation_p.A68T	NM_177964.3	NP_808879.2	Q8NI32	LPD6B_HUMAN	LY6/PLAUR domain containing 6B	68	UPAR/Ly6.					anchored to membrane|plasma membrane				endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11						TTGTGAAAACGCAGGGGATAA	0.373000													74	25					0	0	1	0	0
DPY19L4	286148	broad.mit.edu	37	8	95768289	95768289	+	Missense_Mutation	SNP	T	T	G			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr8:95768289T>G	ENST00000414645.2	+	7	736	c.637T>G	c.(637-639)Tcc>Gcc	p.S213A		NM_181787.2	NP_861452.2	Q7Z388	D19L4_HUMAN	dpy-19-like 4 (C. elegans)	213						integral to membrane				breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	21	Breast(36;3.85e-06)					AATTGAATACTCCATTCCTTT	0.313000													29	57					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86088048	86088048	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr14:86088048G>A	ENST00000330753.4	+	2	957	c.190G>A	c.(190-192)Ggc>Agc	p.G64S	FLRT2_ENST00000554746.1_Missense_Mutation_p.G64S	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	64					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GATCCCGGAGGGCGTAACTGT	0.517000													37	108					0	0	1	0	0
IGLV3-12	28802	broad.mit.edu	37	22	23114830	23114830	+	RNA	SNP	A	A	G			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr22:23114830A>G	ENST00000390313.2	+	0	111																											TGGCCACAGCACAGATGGCCA	0.498000													5	23					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101840287	101840287	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr7:101840287G>A	ENST00000360264.3	+	15	1649	c.1629G>A	c.(1627-1629)atG>atA	p.M543I	CUX1_ENST00000546411.2_Missense_Mutation_p.M430I|CUX1_ENST00000292535.7_Missense_Mutation_p.M532I|CUX1_ENST00000550008.2_Missense_Mutation_p.M532I|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000556210.1_Missense_Mutation_p.M430I|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000437600.4_Intron|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000549414.2_Missense_Mutation_p.M532I	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	532					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						TCAATGGCATGGCCCCATCCC	0.522000													10	146					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139734050	139734050	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr7:139734050G>A	ENST00000263549.3	-	8	2279	c.1406C>T	c.(1405-1407)aCg>aTg	p.T469M	PARP12_ENST00000470515.1_5'UTR	NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	469						nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					TTGCATGGTCGTCACATCCTG	0.493000													13	22					0	0	1	0	0
RHBDF1	64285	broad.mit.edu	37	16	109807	109807	+	Silent	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr16:109807G>A	ENST00000262316.6	-	14	1882	c.1740C>T	c.(1738-1740)agC>agT	p.S580S		NM_022450.3	NP_071895.3	Q96CC6	RHDF1_HUMAN	rhomboid 5 homolog 1 (Drosophila)	580					cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity	p.S580S(1)		breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	18		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				GGTTCCCAGCGCTGTTTTTGG	0.592000													27	25					0	0	1	0	0
RBM46	166863	broad.mit.edu	37	4	155720132	155720132	+	Missense_Mutation	SNP	A	A	G			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr4:155720132A>G	ENST00000510397.1	+	4	997	c.818A>G	c.(817-819)tAt>tGt	p.Y273C	RBM46_ENST00000514866.1_Missense_Mutation_p.Y273C|RBM46_ENST00000281722.3_Missense_Mutation_p.Y273C	NM_001277173.1	NP_001264102.1	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	273	RRM 3.						nucleotide binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|skin(3)|urinary_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0854)				CTTAGAGATTATGCTTTTGTT	0.363000													23	16					0	0	1	0	0
ZMAT3	64393	broad.mit.edu	37	3	178785379	178785379	+	Silent	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:178785379C>T	ENST00000311417.2	-	2	903	c.162G>A	c.(160-162)tcG>tcA	p.S54S	ZMAT3_ENST00000432729.1_Silent_p.S54S	NM_022470.3	NP_071915.1	Q9HA38	ZMAT3_HUMAN	zinc finger, matrin-type 3	54					apoptosis|protein transport|regulation of growth|response to DNA damage stimulus|transmembrane transport	nucleolus	RNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(1)|skin(1)	14	all_cancers(143;3.31e-18)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;6.74e-27)|GBM - Glioblastoma multiforme(14;0.00448)|BRCA - Breast invasive adenocarcinoma(182;0.0527)			CCCCTCCCTTCGATAACTCTT	0.557000													4	79					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86591586	86591586	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr1:86591586G>A	ENST00000370571.2	-	3	799	c.433C>T	c.(433-435)Cac>Tac	p.H145Y	COL24A1_ENST00000436319.1_Missense_Mutation_p.H145Y	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	145	Laminin G-like.|TSP N-terminal.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		CCTCTAATGTGTACTACTAAT	0.358000													5	11					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13735963	13735963	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr5:13735963C>T	ENST00000265104.4	-	67	11638	c.11534G>A	c.(11533-11535)cGc>cAc	p.R3845H		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3845					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CAGAAACTGGCGAAGCGAAGT	0.468000									Kartagener syndrome				66	105					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47088034	47088035	+	Frame_Shift_Ins	INS	-	-	TGTA			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr3:47088034_47088035insTGTA	ENST00000409792.3	-	16	7082_7083	c.7040_7041insTACA	c.(7039-7041)cagfs	p.Q2347fs		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2347	Gln-rich.|Low charge region.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CTGCGGCTGGCTGTACCACCAC	0.455			"""N, F, S, Mis"""		clear cell renal carcinoma								15	48	---	---	---	---					
BRAT1	221927	broad.mit.edu	37	7	2584622	2584622	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr7:2584622delG	ENST00000340611.4	-	4	607	c.351delC	c.(349-351)cccfs	p.P117fs		NM_152743.3	NP_689956.2	Q6PJG6	BRAT1_HUMAN	BRCA1-associated ATM activator 1	117					response to ionizing radiation	nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23						TGCGCACGGTGGGGACGGCCC	0.682													2	4	---	---	---	---					
RNASEH2B	79621	broad.mit.edu	37	13	51530586	51530587	+	Frame_Shift_Ins	INS	-	-	A	rs75254367		TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr13:51530586_51530587insA	ENST00000336617.3	+	11	1314_1315	c.915_916insA	c.(916-918)aaafs	p.K306fs	RNASEH2B_ENST00000422660.1_Intron|RNASEH2B_ENST00000495244.2_3'UTR	NM_024570.3	NP_078846.2	Q5TBB1	RNH2B_HUMAN	ribonuclease H2, subunit B	306					RNA catabolic process	nucleus|ribonuclease H2 complex				endometrium(2)|liver(1)|lung(1)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(7;1.03e-07)|Breast(56;0.00122)|Lung NSC(96;0.00143)|Prostate(109;0.0047)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;9e-08)		GGGTAAAAAATAAAAAAAAAAT	0.297													3	3	---	---	---	---					
LGALS3	3958	broad.mit.edu	37	14	55604096	55604099	+	Frame_Shift_Del	DEL	CAGA	CAGA	-			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr14:55604096_55604099delCAGA	ENST00000254301.9	+	2	266_269	c.5_8delCAGA	c.(4-9)gcagacfs	p.AD2fs	LGALS3_ENST00000554715.1_Frame_Shift_Del_p.AD2fs|LGALS3_ENST00000553755.1_Intron	NM_002306.3	NP_002297.2	P17931	LEG3_HUMAN	lectin, galactoside-binding, soluble, 3	2					cell differentiation|innate immune response|mRNA processing|RNA splicing	mitochondrial inner membrane|plasma membrane|spliceosomal complex	IgE binding|sugar binding			central_nervous_system(1)|endometrium(1)|prostate(1)	3						AGGAAAATGGCAGACAATTTTTCG	0.377													21	116	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25328156	25328156	+	RNA	DEL	T	T	-			TCGA-DH-A669-02A-11D-A31L-08	TCGA-DH-A669-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b020b62a-8acf-40d2-97ab-aa870ac61e96	e849abef-b55e-4124-b760-09101a7c4390	g.chr15:25328156delT	ENST00000546682.1	+	0	188				SNHG14_ENST00000549804.2_RNA	NR_003361.1																						TAGGAAATTGTTTTAGGGACT	0.493													5	5	---	---	---	---					
