Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC26A8	116369	broad.mit.edu	37	6	35980123	35980123	+	Missense_Mutation	SNP	C	C	T			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr6:35980123C>T	ENST00000490799.1	-	3	568	c.215G>A	c.(214-216)tGc>tAc	p.C72Y	SLC26A8_ENST00000355574.2_Missense_Mutation_p.C72Y|SLC26A8_ENST00000394602.2_Missense_Mutation_p.C72Y	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	72					cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						TGTAAGCACGCATCGTAGGAA	0.458000													37	59					0	0	1	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	32					0	0	1	0	0
FAM86FP	653113	broad.mit.edu	37	12	8386955	8386955	+	RNA	SNP	T	T	C	rs75997195		TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr12:8386955T>C	ENST00000427893.2	-	0	811																											CTTGTGCTCCTGGCAGGCAGC	0.612000													6	114					0	0	1	0	0
RAD54B	25788	broad.mit.edu	37	8	95403999	95403999	+	Silent	SNP	G	G	A			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr8:95403999G>A	ENST00000336148.5	-	10	1771	c.1647C>T	c.(1645-1647)tgC>tgT	p.C549C		NM_012415.3	NP_036547.1	O95073	FSBP_HUMAN	RAD54 homolog B (S. cerevisiae)	0					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding	p.C549C(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(10)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			CTCCTGGTCGGCAAAAGACAA	0.398000								Direct reversal of damage;Homologous recombination					4	201					0	0	1	0	0
LMO1	4004	broad.mit.edu	37	11	8252034	8252034	+	Missense_Mutation	SNP	C	C	T			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr11:8252034C>T	ENST00000335790.3	-	2	538	c.43G>A	c.(43-45)Gtc>Atc	p.V15I	LMO1_ENST00000428101.2_Missense_Mutation_p.V14I|LMO1_ENST00000534484.1_Missense_Mutation_p.V4I	NM_002315.2	NP_002306.1	P25800	RBTN1_HUMAN	LIM domain only 1 (rhombotin 1)	15					cell proliferation|multicellular organismal development|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|skin(1)	5				Epithelial(150;1.59e-07)|BRCA - Breast invasive adenocarcinoma(625;0.203)		TTGGGCTGGACGGAGAGCATC	0.592000			"""T, A"""	TRD@	"""T-ALL, neuroblastoma"""	neuroblastoma							16	86					0	0	1	0	0
SATL1	340562	broad.mit.edu	37	X	84362997	84362997	+	Silent	SNP	C	C	T			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chrX:84362997C>T	ENST00000509231.1	-	1	1057	c.978G>A	c.(976-978)agG>agA	p.R326R	SATL1_ENST00000395409.3_Silent_p.R139R|SATL1_ENST00000332921.5_Silent_p.R139R			Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	139	Gln-rich.						N-acetyltransferase activity			NS(1)|breast(5)|endometrium(2)|large_intestine(3)|lung(13)|skin(3)|stomach(1)|urinary_tract(1)	29						CTGGTTGGCTCCTACCTAATT	0.527000													28	7					0	0	1	0	0
PUS7	54517	broad.mit.edu	37	7	105148879	105148879	+	Silent	SNP	A	A	G			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr7:105148879A>G	ENST00000356362.2	-	2	295	c.81T>C	c.(79-81)gtT>gtC	p.V27V	PUS7_ENST00000469408.1_Silent_p.V27V	NM_019042.3	NP_061915.2	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)	27					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|pancreas(1)|skin(1)	23						TTGTCTCTTCAACTGGGACTC	0.473000													50	51					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40670456	40670456	+	Missense_Mutation	SNP	C	C	T			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr21:40670456C>T	ENST00000342449.3	-	5	329	c.251G>A	c.(250-252)cGc>cAc	p.R84H	BRWD1_ENST00000470108.1_5'UTR|BRWD1_ENST00000333229.2_Missense_Mutation_p.R84H|BRWD1_ENST00000380800.3_Missense_Mutation_p.R84H|BRWD1_ENST00000341322.4_Missense_Mutation_p.R84H	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	84					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				AGGACCGATGCGCTGGCAGAT	0.408000													4	142					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	83029362	83029362	+	Missense_Mutation	SNP	C	C	T			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr7:83029362C>T	ENST00000307792.3	-	11	1815	c.1348G>A	c.(1348-1350)Gtc>Atc	p.V450I	SEMA3E_ENST00000427262.1_Missense_Mutation_p.V390I	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	450	Sema.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				ATAAACAAGACGTCATATTGG	0.333000													5	146					0	0	1	0	0
ARMC3	219681	broad.mit.edu	37	10	23326258	23326258	+	Silent	SNP	G	G	A			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr10:23326258G>A	ENST00000298032.5	+	19	2553	c.2469G>A	c.(2467-2469)gcG>gcA	p.A823A	ARMC3_ENST00000376528.4_Silent_p.A560A|ARMC3_ENST00000409983.3_Silent_p.A816A	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	823							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						ACGGTAGAGCGTGGAATGAAG	0.542000													4	65					0	0	1	0	0
GPR111	222611	broad.mit.edu	37	6	47647929	47647929	+	Silent	SNP	T	T	C			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr6:47647929T>C	ENST00000398742.2	+	4	439	c.390T>C	c.(388-390)atT>atC	p.I130I	GPR111_ENST00000296862.1_Silent_p.I198I|GPR111_ENST00000507065.1_Silent_p.I130I			Q8IZF7	GP111_HUMAN	G protein-coupled receptor 111	198					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(15)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						CTTGTGTAATTAGAAACATTC	0.383000													37	51					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15298084	15298084	+	Missense_Mutation	SNP	G	G	A	rs75068032		TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr19:15298084G>A	ENST00000263388.2	-	11	1747	c.1672C>T	c.(1672-1674)Cgc>Tgc	p.R558C		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	558	EGF-like 14; calcium-binding (Potential).		R -> C (in CADASIL).		Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TCCACGCAGCGACCATGGTGG	0.652000													3	39					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70010650	70010650	+	RNA	SNP	A	A	G	rs144900726	by1000genomes	TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr16:70010650A>G	ENST00000531894.1	-	0	3748					NR_003610.1																						AGGGCCGAAGAAGGGAATGTT	0.468000													6	51					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45861581	45861581	+	Missense_Mutation	SNP	C	C	T			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr21:45861581C>T	ENST00000397928.1	+	32	4838	c.4393C>T	c.(4393-4395)Cac>Tac	p.H1465Y	TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Missense_Mutation_p.H1411Y|TRPM2_ENST00000397932.2_Missense_Mutation_p.H1515Y|TRPM2_ENST00000300482.5_Missense_Mutation_p.H1465Y	NM_003307.3	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1465	Nudix hydrolase.					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CCAGAACCTGCACGCCTGCGA	0.662000													3	21					0	0	1	0	0
KBTBD8	84541	broad.mit.edu	37	3	67054339	67054339	+	Silent	SNP	A	A	G			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr3:67054339A>G	ENST00000295568.4	+	3	1001	c.870A>G	c.(868-870)aaA>aaG	p.K290K	KBTBD8_ENST00000417314.2_Silent_p.K316K|KBTBD8_ENST00000460576.1_Intron	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	316										breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		GGGTGTTTAAACTATGCAAAC	0.433000													4	165					0	0	1	0	0
WDR25	79446	broad.mit.edu	37	14	100934452	100934452	+	Missense_Mutation	SNP	G	G	A			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr14:100934452G>A	ENST00000335290.6	+	3	1143	c.917G>A	c.(916-918)cGc>cAc	p.R306H	WDR25_ENST00000402312.3_Missense_Mutation_p.R306H|WDR25_ENST00000554998.1_Missense_Mutation_p.R306H|WDR25_ENST00000542471.2_Missense_Mutation_p.R49H	NM_024515.4	NP_078791.3	Q64LD2	WDR25_HUMAN	WD repeat domain 25	306										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|skin(1)	20		Melanoma(154;0.212)				TGTGGCCGGCGCATCCTCAGT	0.637000													4	175					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791758	42791758	+	Missense_Mutation	SNP	G	G	A			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr19:42791758G>A	ENST00000572681.2	+	6	3439	c.3371G>A	c.(3370-3372)cGg>cAg	p.R1124Q	CIC_ENST00000575354.2_Missense_Mutation_p.R215Q|CIC_ENST00000160740.3_Missense_Mutation_p.R215Q			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	215	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding	p.R215Q(2)		autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				AAGCGGCACCGGGCCCTGGTC	0.612000			"""Mis, F, S"""		oligodendroglioma								34	12					0	0	1	0	0
FAM86FP	653113	broad.mit.edu	37	12	8386973	8386973	+	RNA	SNP	C	C	T			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr12:8386973C>T	ENST00000427893.2	-	0	793																											AGCCAGCCTCCGCAGGACCCC	0.592000													4	87					0	0	1	0	0
ASIP	434	broad.mit.edu	37	20	32856864	32856864	+	Missense_Mutation	SNP	G	G	T			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr20:32856864G>T	ENST00000568305.1	+	4	492	c.290G>T	c.(289-291)cGc>cTc	p.R97L	RP4-785G19.5_ENST00000512005.1_RNA|ASIP_ENST00000374954.3_Missense_Mutation_p.R97L			P42127	ASIP_HUMAN	agouti signaling protein	97	Agouti.				cell-cell signaling|generation of precursor metabolites and energy|hormone-mediated signaling pathway	extracellular space				central_nervous_system(1)|lung(2)	3						GTGGCCACCCGCAACAGCTGC	0.701000													3	7					0.004672	0.004672	1	1	0
NSFL1C	55968	broad.mit.edu	37	20	1433682	1433682	+	Missense_Mutation	SNP	C	C	T			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr20:1433682C>T	ENST00000216879.4	-	6	1508	c.641G>A	c.(640-642)cGc>cAc	p.R214H	NSFL1C_ENST00000350991.4_Missense_Mutation_p.R216H|NSFL1C_ENST00000381658.4_Missense_Mutation_p.R103H|NSFL1C_ENST00000476071.1_Missense_Mutation_p.R216H|NSFL1C_ENST00000353088.2_Missense_Mutation_p.R183H|NSFL1C_ENST00000461211.1_5'UTR	NM_016143.4	NP_057227.2	Q9UNZ2	NSF1C_HUMAN	NSFL1 (p97) cofactor (p47)	214	SEP.					chromosome|Golgi stack|nucleus	lipid binding|protein binding			breast(1)|large_intestine(5)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	16						TCACCCTCTGCGGATAGACTC	0.458000													5	171					0	0	1	0	0
HSD17B8	7923	broad.mit.edu	37	6	33172796	33172796	+	Missense_Mutation	SNP	G	G	A			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr6:33172796G>A	ENST00000374662.3	+	2	197	c.170G>A	c.(169-171)gGg>gAg	p.G57E	HSD17B8_ENST00000469186.1_3'UTR	NM_014234.4	NP_055049.1	Q92506	DHB8_HUMAN	hydroxysteroid (17-beta) dehydrogenase 8	57					estrogen biosynthetic process|fatty acid biosynthetic process	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NAD+) activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|urinary_tract(2)	9					NADH(DB00157)	CTGCTGGGCGGGCCAGGGAGC	0.721000													3	7					0	0	1	0	0
CNOT4	4850	broad.mit.edu	37	7	135073582	135073582	+	Silent	SNP	T	T	C			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr7:135073582T>C	ENST00000428680.2	-	11	1962	c.1683A>G	c.(1681-1683)ggA>ggG	p.G561G	CNOT4_ENST00000315544.5_Silent_p.G564G|CNOT4_ENST00000361528.4_Intron|CNOT4_ENST00000423368.2_Intron|CNOT4_ENST00000356162.4_Intron|CNOT4_ENST00000451834.1_Intron|CNOT4_ENST00000414802.1_Intron|CNOT4_ENST00000541284.1_Intron	NM_001008225.2	NP_001008226.1	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	564					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						TAGGCTGCTGTCCTTGTTGTA	0.488000													21	20					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								15	30					0	0	1	0	0
DHTKD1	55526	broad.mit.edu	37	10	12131003	12131003	+	Nonsense_Mutation	SNP	C	C	T			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr10:12131003C>T	ENST00000263035.4	+	5	798	c.736C>T	c.(736-738)Cga>Tga	p.R246*	DHTKD1_ENST00000465617.1_Intron	NM_018706.5	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	246					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			CCGTAAAATGCGAGGCTTAAG	0.458000													4	94					0	0	1	0	0
CRIPAK	285464	broad.mit.edu	37	4	1388930	1388931	+	Frame_Shift_Ins	INS	-	-	CA	rs71299249		TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr4:1388930_1388931insCA	ENST00000324803.4	+	1	3591_3592	c.631_632insCA	c.(631-633)tcafs	p.S211fs		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	211					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			GCCTGCCTGCTCACACGTGCCC	0.663													7	196	---	---	---	---					
PIK3R1	5295	broad.mit.edu	37	5	67589623	67589634	+	In_Frame_Del	DEL	ATATGATAGATT	ATATGATAGATT	-			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr5:67589623_67589634delATATGATAGATT	ENST00000521381.1	+	11	2002_2013	c.1386_1397delATATGATAGATT	c.(1384-1398)gaatatgatagatta>gaa	p.YDRL463del	PIK3R1_ENST00000320694.8_In_Frame_Del_p.YDRL163del|PIK3R1_ENST00000523872.1_In_Frame_Del_p.YDRL100del|PIK3R1_ENST00000396611.1_In_Frame_Del_p.YDRL463del|PIK3R1_ENST00000521657.1_In_Frame_Del_p.YDRL463del|PIK3R1_ENST00000336483.5_In_Frame_Del_p.YDRL193del|PIK3R1_ENST00000274335.5_In_Frame_Del_p.YDRL463del	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	463					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D464fs*2(1)|p.Y193C(1)|p.0?(1)|p.?(1)|p.D464H(1)|p.Y463fs*1(1)|p.E462_R465delEYDR(1)|p.Y463C(1)|p.Y463_L466del(1)|p.T454_D464del(1)|p.Y163C(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	AAAGTCGAGAATATGATAGATTATATGAAGAA	0.283			"""Mis, F, O"""		"""gliobastoma, ovarian, colorectal"""					TCGA GBM(4;<1E-08)			14	28	---	---	---	---					
KCNMA1	3778	broad.mit.edu	37	10	79397261	79397263	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr10:79397261_79397263delGAA	ENST00000286627.5	-	1	1090_1092	c.138_140delTTC	c.(136-141)tcttcc>tcc	p.46_47SS>S	KCNMA1_ENST00000404857.1_In_Frame_Del_p.46_47SS>S|KCNMA1_ENST00000372440.1_In_Frame_Del_p.46_47SS>S|KCNMA1_ENST00000372443.1_In_Frame_Del_p.46_47SS>S|KCNMA1_ENST00000480683.1_In_Frame_Del_p.46_47SS>S|KCNMA1_ENST00000481070.1_In_Frame_Del_p.46_47SS>S|KCNMA1_ENST00000404771.3_In_Frame_Del_p.46_47SS>S|KCNMA1_ENST00000286628.8_In_Frame_Del_p.46_47SS>S|KCNMA1_ENST00000406533.3_In_Frame_Del_p.46_47SS>S|KCNMA1_ENST00000354353.5_In_Frame_Del_p.46_47SS>S	NM_001271519.1|NM_002247.3	NP_001258448.1|NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	46	Poly-Ser.				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	agaagaagaggaagaggaggagg	0.616													5	8	---	---	---	---					
NEK3	4752	broad.mit.edu	37	13	52725327	52725327	+	Frame_Shift_Del	DEL	A	A	-			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr13:52725327delA	ENST00000400357.2	-	6	1795	c.502delT	c.(502-504)tatfs	p.Y168fs	NEK3_ENST00000339406.3_Frame_Shift_Del_p.Y168fs|NEK3_ENST00000378101.2_Frame_Shift_Del_p.Y168fs|NEK3_ENST00000452082.2_Frame_Shift_Del_p.Y189fs			P51956	NEK3_HUMAN	NIMA-related kinase 3	168	Interaction with VAV2.|Protein kinase.				cell division|mitosis	nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|stomach(2)	18		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.034)|Hepatocellular(98;0.065)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.81e-08)		GGAGGCACATAATAAGGAGTT	0.393													2	4	---	---	---	---					
NPIPB11	728888	broad.mit.edu	37	16	29395145	29395147	+	In_Frame_Del	DEL	TAT	TAT	-			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr16:29395145_29395147delTAT	ENST00000524087.1	-	8	1180_1182	c.1106_1108delATA	c.(1105-1110)aatatc>atc	p.N369del	SNX29P2_ENST00000398878.3_lincRNA					nuclear pore complex interacting protein family, member B11																		GTTGTCTTGATATTATCATCTGC	0.576													2	4	---	---	---	---					
NOVA2	4858	broad.mit.edu	37	19	46476609	46476610	+	Translation_Start_Site	INS	-	-	G			TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr19:46476609_46476610insG	ENST00000263257.5	-	0	194_195					NM_002516.2	NP_002507.1	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2							nucleus	RNA binding			endometrium(3)|large_intestine(5)|lung(13)	21		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		TCGGGCTCCATGGGGGGGGCCT	0.762													3	3	---	---	---	---					
MN1	4330	broad.mit.edu	37	22	28194895	28194900	+	In_Frame_Del	DEL	TGCTGT	TGCTGT	-	rs75719175		TCGA-KT-A74X-01A-11D-A32B-08	TCGA-KT-A74X-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a77fe08f-c159-4135-a722-a811e62197e4	39a20f83-87e5-4f70-a8b8-c470c6ba2ef3	g.chr22:28194895_28194900delTGCTGT	ENST00000302326.4	-	1	2586_2591	c.1632_1637delACAGCA	c.(1630-1638)caacagcag>cag	p.544_546QQQ>Q		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	544	Poly-Gln.						binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						ctgctgctgctgctgttgctgttgct	0.646			T	ETV6	"""AML, meningioma"""								7	6	---	---	---	---					
