Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIF18A	81930	broad.mit.edu	37	11	28098686	28098686	+	Missense_Mutation	SNP	C	C	G			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr11:28098686C>G	ENST00000263181.6	-	10	1583	c.1293G>C	c.(1291-1293)caG>caC	p.Q431H		NM_031217.3	NP_112494.3	Q8NI77	KI18A_HUMAN	kinesin family member 18A	431					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	36						CTTCTCGATTCTGGAACAAGC	0.303000													5	79					0	0	1	0	0
NPIPA5	100288332	broad.mit.edu	37	16	15457701	15457701	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr16:15457701G>A	ENST00000360151.4	-	8	867	c.868C>T	c.(868-870)Ctc>Ttc	p.L290F		NM_001277325.1	NP_001264254.1			nuclear pore complex interacting protein family, member A5									p.L290F(2)									AGGGGAGTGAGCAGACACTCG	0.562000													6	111					0	0	1	0	0
NDST3	9348	broad.mit.edu	37	4	118975673	118975673	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr4:118975673G>A	ENST00000296499.5	+	2	1011	c.608G>A	c.(607-609)cGt>cAt	p.R203H	NDST3_ENST00000433996.2_Missense_Mutation_p.R203H	NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	203	Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						CCATTGATTCGTGTGACCAAA	0.358000													56	79					0	0	1	0	0
MARCH8	220972	broad.mit.edu	37	10	45953818	45953818	+	Missense_Mutation	SNP	T	T	C			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr10:45953818T>C	ENST00000453424.2	-	8	1852	c.1591A>G	c.(1591-1593)Att>Gtt	p.I531V	MARCH8_ENST00000395769.2_Missense_Mutation_p.I249V|MARCH8_ENST00000476962.1_5'UTR|MARCH8_ENST00000395771.3_Missense_Mutation_p.I249V|MARCH8_ENST00000319836.3_Missense_Mutation_p.I249V	NM_001282866.1	NP_001269795.1	Q5T0T0	MARH8_HUMAN	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	249						cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	12						TTTTCAAAAATATTCTTTTTG	0.368000													16	137					0	0	1	0	0
PAX4	5078	broad.mit.edu	37	7	127255074	127255074	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr7:127255074C>T	ENST00000341640.2	-	2	401	c.196G>A	c.(196-198)Gga>Aga	p.G66R	PAX4_ENST00000338516.3_Missense_Mutation_p.G74R|PAX4_ENST00000463946.1_Missense_Mutation_p.G64R|PAX4_ENST00000378740.2_Missense_Mutation_p.G66R	NM_006193.2	NP_006184.2	O43316	PAX4_HUMAN	paired box 4	74	Paired.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						GGCTTGCTTCCCCCAATGCCC	0.577000													7	70					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120350735	120350735	+	Nonsense_Mutation	SNP	G	G	A			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr11:120350735G>A	ENST00000397843.2	+	38	3999	c.3833G>A	c.(3832-3834)tGg>tAg	p.W1278*	ARHGEF12_ENST00000356641.3_Nonsense_Mutation_p.W1259*|ARHGEF12_ENST00000532993.1_Nonsense_Mutation_p.W1175*	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1278					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		CAGGAAGACTGGCAACATTTC	0.463000			T	MLL	AML								30	100					0	0	1	0	0
MDFIC	29969	broad.mit.edu	37	7	114655883	114655883	+	Missense_Mutation	SNP	G	G	T			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr7:114655883G>T	ENST00000257724.3	+	5	1225	c.962G>T	c.(961-963)tGt>tTt	p.C321F	MDFIC_ENST00000393486.1_Missense_Mutation_p.C212F			Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing	212					activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleolus|nucleus	cyclin binding|Tat protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	8						GGGGATGATTGTAACTGCCCT	0.488000													26	199					3.6726e-16	4.02802e-16	1	1	0
NLRP10	338322	broad.mit.edu	37	11	7981342	7981342	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr11:7981342C>T	ENST00000328600.2	-	2	1978	c.1817G>A	c.(1816-1818)aGc>aAc	p.S606N		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	606							ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ACTCAAGCTGCTTTTGACAGA	0.368000													23	40					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25450191	25450191	+	Missense_Mutation	SNP	A	A	G			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr6:25450191A>G	ENST00000329474.6	+	6	805	c.437A>G	c.(436-438)gAc>gGc	p.D146G	LRRC16A_ENST00000377969.3_5'UTR	NM_001173977.1|NM_017640.5	NP_001167448.1|NP_060110.4	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	146					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						GCGCTGTGGGACAGCCAGACC	0.498000													14	16					0	0	1	0	0
MCM7	4176	broad.mit.edu	37	7	99697010	99697010	+	Missense_Mutation	SNP	A	A	C			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr7:99697010A>C	ENST00000303887.5	-	4	938	c.293T>G	c.(292-294)gTc>gGc	p.V98G	MCM7_ENST00000343023.6_Missense_Mutation_p.V98G|MCM7_ENST00000354230.3_5'UTR	NM_005916.3	NP_005907.3	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	98					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding			endometrium(1)|kidney(5)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	AACGTCCAGGACATCTTTATT	0.488000													26	36					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	36961653	36961653	+	Nonsense_Mutation	SNP	T	T	A			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr5:36961653T>A	ENST00000282516.8	+	5	925	c.426T>A	c.(424-426)taT>taA	p.Y142*	NIPBL_ENST00000504430.1_3'UTR|NIPBL_ENST00000448238.2_Nonsense_Mutation_p.Y142*	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	142					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CTTCCAATTATCAACAAACCA	0.333000													35	52					0	0	1	0	0
OR2T11	127077	broad.mit.edu	37	1	248789593	248789593	+	Silent	SNP	C	C	T			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr1:248789593C>T	ENST00000330803.2	-	1	898	c.837G>A	c.(835-837)acG>acA	p.T279T		NM_001001964.1	NP_001001964.1	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene)	279					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(20)|skin(2)	28	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TAAGCATGGGCGTGACAATGG	0.488000													13	58					0	0	1	0	0
PNMA2	10687	broad.mit.edu	37	8	26365638	26365638	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr8:26365638C>T	ENST00000522362.2	-	3	1528	c.634G>A	c.(634-636)Ggc>Agc	p.G212S		NM_007257.5	NP_009188.1	Q9UL42	PNMA2_HUMAN	paraneoplastic Ma antigen 2	212					apoptosis	nucleolus	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)	11		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		agggcagggccccgcaggctt	0.542000													6	100					0	0	1	0	0
ZADH2	284273	broad.mit.edu	37	18	72913697	72913697	+	Missense_Mutation	SNP	C	C	G			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr18:72913697C>G	ENST00000322342.3	-	2	1097	c.808G>C	c.(808-810)Ggg>Cgg	p.G270R	ZADH2_ENST00000537114.2_Missense_Mutation_p.G147R	NM_175907.4	NP_787103.1	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain containing 2	270						peroxisome	oxidoreductase activity|zinc ion binding			endometrium(3)|large_intestine(3)|lung(8)|skin(1)	15		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		GAGATAAACCCTATTACTATC	0.512000													23	43					0	0	1	0	0
DDX41	51428	broad.mit.edu	37	5	176940447	176940447	+	Silent	SNP	C	C	T	rs144382614		TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr5:176940447C>T	ENST00000507955.1	-	11	1660	c.1137G>A	c.(1135-1137)ccG>ccA	p.P379P		NM_016222.2	NP_057306.2	Q9UJV9	DDX41_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 41	379	Helicase ATP-binding.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding					all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			GAATCTTCTTCGGCATGGTGG	0.617000													81	130					0	0	1	0	0
IDH2	3418	broad.mit.edu	37	15	90631838	90631838	+	Missense_Mutation	SNP	C	C	T	rs121913503		TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr15:90631838C>T	ENST00000330062.3	-	4	628	c.515G>A	c.(514-516)aGg>aAg	p.R172K	IDH2_ENST00000559482.1_Intron|IDH2_ENST00000539790.1_Missense_Mutation_p.R42K|IDH2_ENST00000540499.2_Missense_Mutation_p.R120K	NM_002168.2	NP_002159.2	P48735	IDHP_HUMAN	isocitrate dehydrogenase 2 (NADP+), mitochondrial	172					2-oxoglutarate metabolic process|glyoxylate cycle|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding	p.R172K(116)|p.R172M(21)|p.R172N(1)		biliary_tract(11)|bone(19)|central_nervous_system(107)|endometrium(1)|haematopoietic_and_lymphoid_tissue(953)|large_intestine(8)|lung(5)|skin(5)	1109	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.106)			ATGGGCGTGCCTGCCAATGGT	0.632000			M		GBM								25	34					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89924557	89924557	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr5:89924557G>A	ENST00000405460.2	+	8	1513	c.1417G>A	c.(1417-1419)Gat>Aat	p.D473N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	473	Calx-beta 4.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TACTGTGGTTGATGATGATCT	0.478000													20	55					0	0	1	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138195987	138195987	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr6:138195987G>A	ENST00000237289.4	+	3	367	c.301G>A	c.(301-303)Ggc>Agc	p.G101S		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	101	OTU.|TRAF-binding.				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)|p.G101fs*38(1)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		CTCAGGTGACGGCAATTGCCT	0.488000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								3	58					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													5	54					0	0	1	0	0
ERVW-1	30816	broad.mit.edu	37	7	92098171	92098171	+	Nonsense_Mutation	SNP	G	G	A	rs151180490	byFrequency	TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr7:92098171G>A	ENST00000493463.2	-	1	2448	c.1525C>T	c.(1525-1527)Cga>Tga	p.R509*	AC007566.10_ENST00000427458.1_RNA|ERVW-1_ENST00000604270.1_5'UTR|ERVW-1_ENST00000603053.1_Nonsense_Mutation_p.R509*	NM_014590.3	NP_055405.3	Q9UQF0	ENW1_HUMAN		509					syncytium formation	integral to membrane|plasma membrane|virion				endometrium(1)|large_intestine(1)|lung(15)	17						acatcagatcgtgggctagca	0.517000													6	102					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36595107	36595107	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr11:36595107C>T	ENST00000299440.5	+	2	365	c.253C>T	c.(253-255)Cct>Tct	p.P85S		NM_000448.2	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	85	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				AAAAGCCCACCCTAAGTTTTC	0.488000									Familial Hemophagocytic Lymphohistiocytosis				23	56					0	0	1	0	0
ADAM15	8751	broad.mit.edu	37	1	155034402	155034402	+	Missense_Mutation	SNP	A	A	G			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr1:155034402A>G	ENST00000356955.2	+	21	2476	c.2375A>G	c.(2374-2376)aAt>aGt	p.N792S	ADAM15_ENST00000271836.6_Intron|ADAM15_ENST00000368410.2_Intron|ADAM15_ENST00000360674.4_Intron|ADAM15_ENST00000368412.3_Intron|ADAM15_ENST00000531455.1_Intron|ADAM15_ENST00000355956.2_Intron|ADAM15_ENST00000359280.4_Missense_Mutation_p.N767S|ADAM15_ENST00000472434.1_3'UTR|ADAM15_ENST00000368413.1_Intron|ADAM15_ENST00000449910.2_Missense_Mutation_p.N791S	NM_207197.2	NP_997080.1	Q13444	ADA15_HUMAN	ADAM metallopeptidase domain 15	792					angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(5)|urinary_tract(1)	39	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GACCGACCCAATCCCCCTACC	0.647000											OREG0013848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	63	82					0	0	1	0	0
MAK16	84549	broad.mit.edu	37	8	33346581	33346581	+	Nonsense_Mutation	SNP	C	C	T			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr8:33346581C>T	ENST00000360128.6	+	5	773	c.316C>T	c.(316-318)Cga>Tga	p.R106*	TTI2_ENST00000519356.1_Intron	NM_032509.3	NP_115898.2	Q9BXY0	MAK16_HUMAN	MAK16 homolog (S. cerevisiae)	106						nucleolus				endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|urinary_tract(1)	8						CCGTTTCATTCGACACAAATG	0.373000													26	48					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348739	197348739	+	RNA	SNP	G	G	C			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr3:197348739G>C	ENST00000418868.1	-	0	520					NR_003266.2																						TAATTTTCTAGCTGTGAAAGA	0.398000													5	118					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55221570	55221570	+	RNA	SNP	A	A	C			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr19:55221570A>C	ENST00000413439.1	+	0	1350																											TACAGATGCTACGGTGCACAC	0.677000													3	24					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98928369	98928369	+	Missense_Mutation	SNP	G	G	T			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr2:98928369G>T	ENST00000477737.1	+	27	3813	c.3609G>T	c.(3607-3609)gaG>gaT	p.E1203D	VWA3B_ENST00000490947.2_3'UTR	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1203										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CAAGACGAGAGAAGCCCAGGA	0.612000													3	9					0.150653	0.150653	1	1	0
EAF2	55840	broad.mit.edu	37	3	121554193	121554193	+	Nonsense_Mutation	SNP	G	G	T			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr3:121554193G>T	ENST00000273668.2	+	1	132	c.61G>T	c.(61-63)Gag>Tag	p.E21*	EAF2_ENST00000451944.2_Nonsense_Mutation_p.E21*|EAF2_ENST00000465664.1_3'UTR	NM_018456.4	NP_060926.2	Q96CJ1	EAF2_HUMAN	ELL associated factor 2	21	Necessary for interaction with ELL.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)	9				GBM - Glioblastoma multiforme(114;0.0972)		CAAGTTAGGGGAGAGTTTCGA	0.592000													12	18					5.50884e-06	5.85314e-06	1	1	0
C3orf30	152405	broad.mit.edu	37	3	118865903	118865903	+	Silent	SNP	G	G	A			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr3:118865903G>A	ENST00000295622.1	+	1	907	c.867G>A	c.(865-867)caG>caA	p.Q289Q		NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	289										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		CTTCTGAGCAGACTGACCTCA	0.493000													3	42					0	0	1	0	0
AC073321.4	0	broad.mit.edu	37	2	217475031	217475032	+	RNA	INS	-	-	A	rs71401156		TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr2:217475031_217475032insA	ENST00000441803.1	+	0	195																											AATTTTATTTCAAAAAAAAAAA	0.376													3	5	---	---	---	---					
PBX2P1	5088	broad.mit.edu	37	3	142895155	142895155	+	RNA	DEL	C	C	-			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr3:142895155delC	ENST00000560287.1	+	0	29																											GGCCTCAGGGCCCCCCCCCAG	0.746													4	2	---	---	---	---					
SYNPO	11346	broad.mit.edu	37	5	150036401	150036401	+	Frame_Shift_Del	DEL	C	C	-			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr5:150036401delC	ENST00000307662.4	+	3	2993	c.2464delC	c.(2464-2466)cccfs	p.P822fs		NM_007286.5	NP_009217.3	Q8N3V7	SYNPO_HUMAN	synaptopodin	878	Pro-rich.				positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			NS(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(4)|prostate(1)|urinary_tract(2)	18		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCCTTCGCGCCCATCCCGCG	0.821													2	4	---	---	---	---					
BUD31	8896	broad.mit.edu	37	7	99015057	99015058	+	Frame_Shift_Del	DEL	TA	TA	-			TCGA-P5-A730-01A-11D-A32B-08	TCGA-P5-A730-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8be88dff-3e17-4c99-a334-a9cc7c045ba2	c6b43adc-7b1f-44df-bea6-9448d31209c4	g.chr7:99015057_99015058delTA	ENST00000403633.2	+	5	752_753	c.223_224delTA	c.(223-225)tatfs	p.Y75fs	BUD31_ENST00000431419.1_Frame_Shift_Del_p.Y46fs|BUD31_ENST00000222969.5_Frame_Shift_Del_p.Y75fs|BUD31_ENST00000456893.1_Frame_Shift_Del_p.Y34fs|PTCD1_ENST00000292478.4_3'UTR			P41223	BUD31_HUMAN	BUD31 homolog (S. cerevisiae)	75				YEYCI -> LDICY (in Ref. 1; AAA20008).	regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|ovary(1)	4	all_cancers(62;1.76e-08)|all_epithelial(64;1.63e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GACAGAACTCTATGAATATTGT	0.436													14	37	---	---	---	---					
